MCID: URT039
MIFTS: 64

Urticaria malady

Skin diseases category
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Summaries for Urticaria

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Disease Ontology:8 A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located in the upper dermis.

MalaCards based summary: Urticaria is related to urticaria pigmentosa and mastocytosis. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Melanocyte Development and Pigmentation and Leukotriene modifiers pathway, Pharmacodynamics. The drugs diphenhydramine hydrochloride and chlorpheniramine and the compounds 15hpete and 15-hydroperoxyeicosatetraenoic acid have been mentioned in the context of this disorder. Affiliated tissues include the upper dermis, skin and testes, and related mouse phenotypes are cardiovascular system and skeleton.

Wikipedia:65 Urticaria (from the Latin urtica, \"nettle\" from urere, \"to burn\"), commonly referred to as hives, is... more...

Aliases & Classifications for Urticaria

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Urticaria, Aliases & Descriptions:

Name: Urticaria 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:1555
MeSH34 D014581
ICD9CM27 708.8

Related Diseases for Urticaria

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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 279)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa32.2KITLG, KIT
2mastocytosis31.2KITLG, KIT, CMA1
3asthma31.2RNASE3, LTC4S
4systemic mastocytosis31.0KIT, KITLG
5allergic rhinitis31.0RNASE3, ALOX5
6angioedema30.9ALOX5, LTC4S, HNMT, RNASE3, PTGS1
7rhinitis30.9RNASE3, PTGS1, CMA1
8atopic dermatitis30.6FCER1A, RNASE3
9dermatitis30.4ITGB2, CMA1, ALOX5, NLRP3
10atopy30.4RNASE3, LTC4S, CMA1
11psoriasis30.4ITGB2, RNASE3, CMA1, ALOX5
12hypereosinophilic syndrome30.3RNASE3, KIT
13allergic asthma30.2ITGB2, CMA1, RNASE3, ALOX5
14acute lymphoblastic leukemia30.2KITLG, KIT, ITGB2
15neurofibroma30.1KIT, KITLG
16pneumonia30.1HRH2, PTGS1
17gastroesophageal reflux disease30.1PTGS1, HRH2
18polycythemia vera30.1KIT, KITLG
19sinusitis30.1ALOX5, RNASE3, LTC4S
20eosinophilia30.0ALOX5, RNASE3, ITGB2
21gastrointestinal stromal tumor30.0KITLG, KIT
22conjunctivitis30.0RNASE3, NLRP3
23mast cell neoplasm29.8KITLG, CMA1, KIT, LTC4S
24rheumatoid arthritis29.8ALOX5, ITGB2, RNASE3, PTGS1
25melanoma29.8ALOX5, KIT, KITLG, PTGS1, HRH2
26leukemia29.5KITLG, PTGS1, RNASE3, LTC4S, HRH2, KIT
27arthritis29.4ITGB2, PTGS1, NLRP3, ALOX5, HRH2
28solar urticaria10.9
29cholinergic urticaria10.8
30papular urticaria10.7
31aquagenic urticaria10.7
32cold contact urticaria10.6
33chronic cystitis10.5PTGS1
34kimura disease10.5RNASE3
35keratoconjunctivitis10.5RNASE3
36thyroiditis10.5
37schnitzler syndrome10.4
38allergic urticaria10.4
39familial cold autoinflammatory syndrome10.4
40piebaldism10.4KIT, KITLG
41dysgerminoma10.4KIT, KITLG
42muckle-wells syndrome10.3
43blindness10.3
44refractory anemia10.3KIT, KITLG
45pdgfrb-associated chronic eosinophilic leukemia10.3KITLG, KIT
46hemorrhagic thrombocythemia10.3KITLG, KIT
47hypohidrosis10.3
48vernal keratoconjunctivitis10.3RNASE3, CMA1
49stomach disease10.3PTGS1, HRH2
50cutaneous mastocytosis10.3

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Symptoms for Urticaria

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Genetic Tests for Urticaria

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Anatomical Context for Urticaria

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MalaCards organs/tissues related to Urticaria:

32
Skin, Testes, Thyroid, Bone, Neutrophil, T cells, Bone marrow, Endothelial, Eye, Lung, Tonsil, Monocytes, B cells, Whole blood, Smooth muscle, Small intestine, Colon, Breast, Prostate

FMA organs/tissues related to Urticaria:

14
The upper dermis

Animal Models for Urticaria or affiliated genes

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MGI Mouse Phenotypes related to Urticaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0PTGS1, FCER1A, ITGB2, ALOX5, KIT, KITLG
2MP:00053908.0PTGS1, ITGB2, ALOX5, KIT, KITLG, NLRP3
3MP:00053848.0NLRP3, KITLG, KIT, ALOX5, ITGB2, PTGS1
4MP:00053817.9PTGS1, KIT, KITLG, NLRP3, HRH2
5MP:00107717.9PTGS1, ITGB2, KIT, KITLG, NLRP3, LTC4S
6MP:00053977.1PTGS1, FCER1A, CMA1, ITGB2, ALOX5, KIT
7MP:00053767.0PTGS1, FCER1A, ITGB2, ALOX5, KIT, KITLG
8MP:00053876.6LTC4S, PTGS1, FCER1A, CPN1, CMA1, ITGB2

Publications for Urticaria

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Articles related to Urticaria:

(show top 50)    (show all 1445)
idTitleAuthorsYear
1
Chronic urticaria in a celiac patient: role of food allergy. (25345308)
2014
2
Successful use of mycophenolate mofetil to treat severe chronic urticaria in a patient intolerant to ciclosporin. (23692555)
2014
3
Acute urticaria. (24262686)
2014
4
Chronic urticaria: new management options. (25383135)
2014
5
Herpesvirus-associated acute urticaria: an age matched case-control study. (24386470)
2013
6
Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. (23711867)
2013
7
Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection. (22924754)
2013
8
Identifying core herbal treatments for urticaria using Taiwan's nationwide prescription database. (23684721)
2013
9
Delayed onset urticaria in depressive patients with bupropion prescription: a nationwide population-based study. (24244611)
2013
10
Chronic urticaria in myasthenia gravis patients - More than occasional coexistence? (23972403)
2013
11
The role of autoimmune testing in chronic idiopathic urticaria. (22541405)
2012
12
Occupational allergic contact urticaria to crustacean in a cook. (22533241)
2012
13
Treatment of severe cold contact urticaria with omalizumab: case reports. (23341807)
2012
14
What is your diagnosis? Urticaria multiforme. (22838086)
2012
15
Cold-induced urticaria with a familial transmission: a case report and review of the literature. (22348744)
2012
16
Class action of oral coumarins in the treatment of a patient with chronic spontaneous urticaria and delayed-pressure urticaria. (22439898)
2012
17
Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria. (21985375)
2011
18
Fexofenadine-induced urticaria. (22346270)
2011
19
Cross-cultural adaptation of the Brazilian-Portuguese version of the chronic urticaria quality-of-life questionnaire - CU-Q2oL. (21899558)
2011
20
Rapid desensitization with autologous sweat in cholinergic urticaria. (21364312)
2011
21
Specific pattern of flea antigen recognition by IgG subclass and IgE during the progression of papular urticaria caused by flea bite. (20227159)
2010
22
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. (19178400)
2009
23
Occupational contact urticaria caused by cyclic acid anhydrides. (19338590)
2009
24
Influence of penetrative needling of Shendao (GV 11) on the symptom score and serum IgE content in chronic urticaria patients]. (19916293)
2009
25
Generalized brownish macules in infancy. Urticaria pigmentosa. (19873965)
2009
26
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
27
Synergistic effect of broad-spectrum sunscreens and antihistamines in the control of idiopathic solar urticaria. (18559766)
2008
28
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
29
The thyroid and urticaria. (16131915)
2005
30
Fixed solar urticaria induced by UVA and visible light: a report of a case. (15752128)
2005
31
Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients. (16076300)
2005
32
Interleukin-31. A messenger of T-cells inducing urticaria and eczema reactions]. (15635736)
2004
33
Drug-induced urticaria--activity of selected cytokines and acute phase proteins in plasma. (15314956)
2003
34
Drug-induced chronic urticarias]. (12843807)
2003
35
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
36
Urticaria pigmentosa: a clinical, hematopathologic, and serologic study of 30 adults. (9495199)
1998
37
Enhanced P-selectin expression in chronic and dermographic urticaria. (9303336)
1997
38
Urticaria pigmentosa mimicking xanthoma disseminatum. (20952937)
1995
39
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)
1994
40
Chronic idiopathic urticaria: possible contribution of histamine-releasing factor to pathogenesis. (7687607)
1993
41
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984
42
Production and inhibition of solar urticaria by visible light exposure. (6512054)
1984
43
Heat urticaria clinically simulating solar urticaria. (6590049)
1984
44
Immunohistochemical localization of somatostatin-like immunoreactivity in skin lesions from patients with urticaria pigmentosa. (6206641)
1984
45
Solar urticaria. (873670)
1977
46
Cholinergic urticaria with systemic presentation. (5470989)
1970
47
Urticaria pigmentosa. Age of onset and prognosis. (13938746)
1962
48
Urticaria pigmentosa, effects of reserpine. (13711436)
1961
49
Urticaria pigmentosa associated with bone lesions; a survey and report of eight cases. (12981299)
1952
50
Urticaria pigmentosa. (15433453)
1950

Variations for Urticaria

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Expression for genes affiliated with Urticaria

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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

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Pathways related to Urticaria according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KITLG, KIT
29.8LTC4S, ALOX5
3
Show member pathways
9.5LTC4S, ALOX5, PTGS1
4
Show member pathways
aspirin triggered resolvin E biosynthesis37
9.5LTC4S, ALOX5, PTGS1
59.5ALOX5, KIT, KITLG
6
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.4KITLG, KIT, ITGB2
7
Show member pathways
9.3FCER1A, RNASE3, ITGB2
8
Show member pathways
8.9FCER1A, ITGB2, KIT, KITLG
9
Show member pathways
8.9KITLG, KIT, ITGB2, FCER1A
10
Show member pathways
8.9FCER1A, CMA1, KIT, KITLG
11
Show member pathways
8.3LTC4S, PTGS1, FCER1A, ALOX5, KIT, KITLG

Compounds for genes affiliated with Urticaria

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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
115hpete4410.2ALOX5, PTGS1
215-hydroperoxyeicosatetraenoic acid4410.2PTGS1, ALOX5
3licofelone4410.2PTGS1, ALOX5
4Leukotriene A42410.2LTC4S, ALOX5
5phenidone4410.1PTGS1, ALOX5
6balsalazide44 1111.1ALOX5, PTGS1
7diethylcarbamazine44 1111.1ALOX5, PTGS1
8monochloroacetic acid4410.0KITLG, KIT
9zafirlukast44 28 1112.0ALOX5, RNASE3, PTGS1
1015-hydroxyeicosatetraenoic acid449.9PTGS1, ALOX5
11ltd4449.9LTC4S, ALOX5, RNASE3
12zileuton44 61 28 1112.9ALOX5, PTGS1, LTC4S
13anti-histamine449.9ALOX5, RNASE3, KITLG
14meclofenamic acid44 1110.9ALOX5, PTGS1
15budesonide44 50 1111.9KITLG, PTGS1, RNASE3
16txb2449.9PTGS1, RNASE3, ALOX5
17n-formylmethionyl-leucylphenylalanine449.7RNASE3, ITGB2, ALOX5
18lte4449.7PTGS1, RNASE3, ALOX5, LTC4S
19montelukast44 50 28 1112.7ALOX5, LTC4S, PTGS1, RNASE3
20quinacrine44 1110.6PTGS1, ALOX5, HNMT
21diclofenac44 28 50 1112.6PTGS1, ALOX5, HRH2
22theophylline44 28 24 1112.5HRH2, RNASE3, ALOX5
23hydroxyurea44 50 1111.5KITLG, KIT, ALOX5
24celecoxib44 61 28 50 24 1114.5PTGS1, ALOX5, HRH2
25diphenhydramine44 28 2 24 1113.4PTGS1, HNMT, HRH2
26herbimycin a44 6110.4ITGB2, ALOX5, PTGS1, KITLG
27salbutamol44 50 28 24 1113.3HRH2, KITLG, RNASE3, ITGB2
28imidazole449.3HNMT, HRH2, ALOX5
29prostaglandin449.3PTGS1, HRH2, KITLG, ALOX5
30pgd2449.3ALOX5, LTC4S, KITLG, PTGS1, RNASE3
31ltc4449.3ALOX5, LTC4S, ITGB2, RNASE3, PTGS1
32leukotriene b444 61 2411.3ALOX5, RNASE3, PTGS1, ITGB2, LTC4S
33epinephrine44 24 1111.2RNASE3, ALOX5, KITLG, HRH2
34dmso449.2ALOX5, KITLG, LTC4S, ITGB2, PTGS1
35cycloheximide449.1ALOX5, PTGS1, KITLG, ITGB2, KIT
36arachidonic acid44 28 24 1112.1PTGS1, ALOX5, KITLG, LTC4S
37ethanol44 50 24 1112.1HRH2, RNASE3, KITLG, ITGB2
38h2o2449.1ITGB2, RNASE3, KITLG, ALOX5, PTGS1
39paraffin449.0CMA1, PTGS1, KITLG, KIT
40heparin44 28 24 1112.0ITGB2, KITLG, RNASE3, ALOX5, CMA1
41vegf448.9ITGB2, PTGS1, RNASE3, ALOX5, KIT, KITLG
42dexamethasone44 50 28 1111.9RNASE3, PTGS1, ITGB2, ALOX5, KITLG, LTC4S
43pge2448.8HRH2, LTC4S, RNASE3, KITLG, PTGS1, ALOX5
44lactate448.7ITGB2, KITLG, HRH2, PTGS1, RNASE3, KIT
45genistein44 28 61 2 24 1113.7PTGS1, ITGB2, KITLG, ALOX5
46nitric oxide44 24 1110.7KITLG, KIT, ITGB2, PTGS1, RNASE3, HRH2
47serine448.2ITGB2, ALOX5, KIT, KITLG, HRH2, CMA1
48aspirin44 50 28 2411.2HNMT, RNASE3, PTGS1, ALOX5, KITLG, HRH2
49calcium44 50 24 1110.9CMA1, KIT, ITGB2, KITLG, HRH2, LTC4S
50histamine44 28 248.8HRH2, RNASE3, CMA1, LTC4S, ITGB2, HNMT

GO Terms for genes affiliated with Urticaria

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Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:03523410.0KITLG, KIT
2lipoxin metabolic processGO:200130010.0LTC4S, ALOX5
3lipoxygenase pathwayGO:01937210.0ALOX5, LTC4S
4leukotriene metabolic processGO:0066919.9LTC4S, ALOX5
5embryonic hemopoiesisGO:0351629.9KITLG, KIT
6arachidonic acid metabolic processGO:0193699.7LTC4S, ALOX5, PTGS1
7digestive tract developmentGO:0485659.6HRH2, KIT
8leukotriene biosynthetic processGO:0193709.5LTC4S, ALOX5, FCER1A
9visual learningGO:0085429.4HRH2, KIT
10Fc-epsilon receptor signaling pathwayGO:0380959.3FCER1A, KIT, KITLG
11inflammatory responseGO:0069549.0NLRP3, KIT, ITGB2
12innate immune responseGO:0450878.3FCER1A, ITGB2, KIT, KITLG, NLRP3

Products for genes affiliated with Urticaria

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  • Antibodies
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Sources for Urticaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet