MCID: URT039
MIFTS: 61

Urticaria malady

Summaries for Urticaria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urticaria (from the Latin urtica, nettle,) commonly referred to as hives, is a kind of skin rash notable... more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Lymphocyte Signaling and Fc epsilon receptor (FCERI) signaling. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds histamine and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and thyroid, and related mouse phenotypes are immune system and cardiovascular system.

Aliases & Classifications for Urticaria

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

urticaria 8 10 44 60


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Disease Ontology8 DOID:1555
ICD9CM27 708.8
MeSH34 D014581

Related Diseases for Urticaria

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17GeneCards, 18GeneDecks
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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa31.6KIT, KITLG
2angioedema31.0C1S, HNMT, IGHE, LTC4S, RNASE3, HRH1
3dermatitis30.6NLRP3, ITGB2, IGHE, CMA1, ALOX5
4asthma30.5RNASE3, ALOX5
5rhinitis30.4IGHE, PRG2, RNASE3, HRH1, TPT1, PTGS1
6systemic mastocytosis30.4KITLG, KIT
7allergic rhinitis30.4IGHE, RNASE3, HRH1, ALOX5
8skin disease30.3HRH1, RNASE3, IGHE, ITGB2
9leukemia30.3ITGB2, PRG2, LTC4S, RNASE3, HRH1, KITLG
10atopic dermatitis30.3PRG2, IGHE, RNASE3, HRH1, CMA1, KITLG
11dermatographia30.3IGHE, PRG2
12psoriasis30.3ITGB2, RNASE3, CMA1, ALOX5
13allergic asthma30.2ITGB2, IGHE, RNASE3, HRH1, CMA1, ALOX5
14chronic rhinitis30.2HRH1, RNASE3
15vasculitis30.1PRG2, ITGB2, C1S
16melanoma29.9PRG2, HRH1, KITLG, KIT, PTGS1, ALOX5
17eosinophilia29.9ITGB2, PRG2, IGHE, RNASE3, ALOX5
18mastocytosis29.9IGHE, CMA1, KITLG, KIT
19arthritis29.9NLRP3, ITGB2, PTGS1, ALOX5
20glomerulonephritis29.9ITGB2, ALOX5
21malaria29.9TPT1, HRH1
22gastritis29.9PTGS1
23anisakiasis29.9RNASE3, IGHE
24toxocariasis29.9IGHE, RNASE3
25mast-cell leukemia29.9KIT, KITLG
26rheumatoid arthritis29.6C1S, ITGB2, PRG2, RNASE3, HRH1, PTGS1
27food allergy29.6C1S, IGHE, RNASE3, TPT1
28mast cell neoplasm29.6KIT, KITLG, CMA1, LTC4S
29conjunctivitis29.6NLRP3, IGHE, RNASE3, HRH1
30allergic conjunctivitis29.6IGHE, RNASE3, HRH1
31pneumonia29.6HRH1, PTGS1
32bullous pemphigoid29.6RNASE3, IGHE, PRG2
33polycythemia vera29.6KITLG, KIT
34eosinophilic gastroenteritis29.6IGHE
35churg-strauss syndrome29.6RNASE3
36polycythemia29.6KITLG
37cystic fibrosis29.6RNASE3
38paragonimiasis29.6IGHE
39myeloma29.6ITGB2, IGHE, KITLG
40cholinergic urticaria10.8
41allergic urticaria10.6
42thyroiditis10.5
43cold contact urticaria10.5
44schnitzler syndrome10.4
45familial cold autoinflammatory syndrome10.3
46aquagenic urticaria10.3
47cutaneous mastocytosis10.3
48autoimmune thyroiditis10.3
49hypohidrosis10.3
50muckle-wells syndrome10.3

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Clinical Features for Urticaria

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Genetic Tests for Urticaria

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Anatomical Context for Urticaria

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32MalaCards
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MalaCards organs/tissues related to Urticaria:

32
Skin, Testes, Thyroid, Bone, T cells, Bone marrow, Endothelial, Lung, B cells, Eye, Monocytes, Tonsil, Whole blood, Prostate, Smooth muscle, Small intestine, Colon, Breast

Animal Models for Urticaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urticaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8CPN1, NLRP3, ITGB2, PRG2, IGHE, LTC4S
2MP:000538510.7LTC4S, KITLG, KIT, FCER1A, TCAP, PTGS1
3MP:000539710.6NLRP3, ITGB2, PRG2, IGHE, HRH1, KITLG
4MP:000537610.4HRH1, IGHE, ITGB2, NLRP3, KITLG, KIT

Publications for Urticaria

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50PubMed
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Articles related to Urticaria:

(show top 50)    (show all 1417)
idTitleAuthorsYear
1
Immunologic contact urticaria. (24262696)
2014
2
Occupational rhinitis, asthma, and contact urticaria caused by hydrolyzed wheat protein in hairdressers. (24267377)
2013
3
Late onset anaphylaxis in a hydatid cyst case presenting with chronic urticaria. (23956751)
2013
4
Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance. (23278883)
2013
5
Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. (23432142)
2013
6
The general characteristics of acute urticaria attacks and the factors predictive of progression to chronic urticaria. (23041256)
2013
7
Effects of Omalizumab in a patient with three types of chronic urticaria. (24102388)
2013
8
Cost-intensive, time-consuming, problematical? How physicians in private practice experience the care of urticaria patients. (22111985)
2012
9
Anaphylaxis and blue urticaria associated with Patent Blue V injection. (23033821)
2012
10
Skin autoreactivity in Hashimoto's thyroiditis patients without urticaria: autologous serum skin test positivity correlation with thyroid antibodies, sonographical volume and grading. (22503840)
2012
11
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. (21834936)
2011
12
Urticaria, angioedema and dyspnoea in adjuvant therapy of melanoma with interferon alpha-2b. (20526557)
2010
13
HLA status in patients with chronic spontaneous urticaria. (20559009)
2010
14
Occupational contact urticaria caused by cyclic acid anhydrides. (19338590)
2009
15
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
16
Is silent sinusitis a cause of chronic urticaria in children? (19839495)
2009
17
Evaluation of autologous serum skin test results in patients with chronic idiopathic urticaria, allergic/non-allergic asthma or rhinitis and healthy people. (18954415)
2008
18
Evidence of in vivo basophil activation in chronic idiopathic urticaria. (16776678)
2006
19
Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. (16891214)
2006
20
Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum. (16675340)
2006
21
Familial aquagenic urticaria and bernard-soulier syndrome. (16319487)
2006
22
Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals. (15721839)
2005
23
Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. (16136765)
2005
24
Interleukin-31. A messenger of T-cells inducing urticaria and eczema reactions]. (15635736)
2004
25
Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. (15347373)
2004
26
Mast cells with bilobed or multilobed nuclei in a nodular lesion of a patient with urticaria pigmentosa. (12454601)
2002
27
Solar urticaria. (10651686)
2000
28
Asthma and gastroesophageal reflux in a girl with urticaria pigmentosa. (11059552)
2000
29
Porphyria cutanea tarda presenting as solar urticaria. (10583087)
1999
30
Upregulation of TNF-alpha and IL-3 expression in lesional and uninvolved skin in different types of urticaria. (9949323)
1999
31
Solar urticaria enhanced through clothing. (9826887)
1998
32
Beta 2-integrins in different forms of urticaria. (7545421)
1995
33
Prevalence of cholinergic urticaria in young adults. (7962780)
1994
34
Histamine stimulates normal human melanocytes in vitro: one of the possible inducers of hyperpigmentation in urticaria pigmentosa. (8274460)
1993
35
Mastocytosis and atopy: a study of 33 patients with urticaria pigmentosa. (2288395)
1990
36
A histological study of the evolution of solar urticaria. (3337546)
1988
37
Solar urticaria--effective treatment by plasmapheresis. (3690881)
1987
38
Papular urticaria caused by Dermestes maculatus Degeer. (3978869)
1985
39
Urticaria, vasculitis, hypocomplementemia, and immune-complex glomerulonephritis. (6460484)
1982
40
Decreased urinary histamine metabolite after successful PUVA treatment of urticaria pigmentosa. (7462662)
1981
41
Urticaria pigmentosa in two pairs of monozygotic twins. (396315)
1979
42
Tests to establish the diagnosis in cholinergic urticaria. (626713)
1978
43
Urticaria pigmentosa. (1010614)
1976
44
Pathogenesis of solar urticaria. Sweat droplet in testing for photosensitivity. (942219)
1976
45
Urticaria pigmentosa with generalized tissue mastocytosis and blood basophilia. (13794652)
1960
46
Urticaria pigmentosa and allied disorders. (13596517)
1958
47
Urticaria pigmentosa; mastocytosis; a consideration of various manifestations. (13457435)
1957
48
Generalized mast cell disease and urticaria pigmentosa; report of a case. (13441357)
1957
49
Papular urticaria. (18098627)
1948
50
Urticaria Pigmentosa. (19973464)
1909

Genetic Variations for Urticaria

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Expression for genes affiliated with Urticaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

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4Cell Signaling Technology, 53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Urticaria

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.3LTC4S, IGHE, PRG2, ITGB2, HNMT, HRH1
2calcium44 49 11 2414.2CMA1, KIT, KITLG, C1S, ITGB2, PRG2
3aspirin44 49 28 2414.1HNMT, PTGS1, LTC4S, RNASE3, HRH1, KITLG
4pgd24411.1ALOX5, PTGS1, KITLG, RNASE3, LTC4S, IGHE
5dexamethasone44 49 28 1114.1ITGB2, LTC4S, RNASE3, PTGS1, HRH1, KITLG
6ltc44411.1RNASE3, ALOX5, LTC4S, PRG2, ITGB2, PTGS1
7nitric oxide44 11 2413.1RNASE3, PRG2, ITGB2, HRH1, KITLG, PTGS1
8allergens4411.1HRH1, RNASE3, ENPP3, TPT1, PRG2, IGHE
9lactate4411.1IGHE, ITGB2, TPT1, PTGS1, KIT, KITLG
10heparin44 28 11 2414.1ALOX5, CMA1, RNASE3, PRG2, ITGB2, C1S
11montelukast44 49 28 1114.1ALOX5, PTGS1, RNASE3, LTC4S, IGHE
12anti-histamine4411.1IGHE, RNASE3, HRH1, ALOX5, KITLG
13leukotriene b444 59 2413.0PTGS1, RNASE3, ITGB2, LTC4S, ALOX5
14nedocromil sodium4411.0ALOX5, RNASE3, HRH1, TPT1, IGHE
15indomethacin44 59 28 1114.0ITGB2, PRG2, ALOX5, IGHE, PTGS1, HRH1
16lte44411.0ALOX5, PTGS1, LTC4S, RNASE3
17ltd44411.0ALOX5, RNASE3, LTC4S, HRH1
18azelastine44 1112.0ALOX5, IGHE, HRH1, RNASE3
19budesonide44 49 1113.0RNASE3, KITLG, IGHE, PTGS1
20salbutamol44 49 28 11 2415.0KITLG, RNASE3, IGHE, ITGB2
21txb24411.0RNASE3, ALOX5, PTGS1, C1S
22fmlp4411.0RNASE3, PRG2, ITGB2, ALOX5, TPT1
23diethylcarbamazine44 1112.0ALOX5, IGHE, PTGS1
24arachidonic acid44 28 11 2414.0TPT1, ALOX5, PTGS1, KITLG, HRH1, LTC4S
25vegf4411.0PTGS1, KIT, RNASE3, IGHE, ITGB2, ALOX5
26dmso4411.0LTC4S, KITLG, PTGS1, ITGB2, ALOX5
27capsaicin44 2811.9RNASE3, CMA1, HRH1, IGHE
28sodium cromoglycate4410.9RNASE3, IGHE, HRH1
29toluene diisocyanate4410.9RNASE3, HNMT, IGHE
30zafirlukast44 28 1112.9RNASE3, ALOX5, PTGS1
31arginine4410.9ITGB2, C1S, IGHE, CPN1, PRG2, ALOX5
32cetirizine44 28 11 2413.9RNASE3, IGHE, HRH1
33loratadine44 11 2412.9IGHE, HRH1, RNASE3
34zileuton59 44 28 1113.9LTC4S, PTGS1, ALOX5
35rantes4410.9HRH1, KITLG, ITGB2, RNASE3, TPT1
36ketotifen44 1111.9HRH1, RNASE3, IGHE
37antimycin a4410.9RNASE3, ALOX5, PRG2
38epinephrine44 11 2412.9ALOX5, IGHE, RNASE3, KITLG, HRH1
39diphenhydramine44 28 2 11 2414.8HNMT, PTGS1, HRH1
40pge24410.8LTC4S
41aspartate4410.8IGHE, ITGB2, HRH1, ALOX5
42latex4410.8KITLG, RNASE3, IGHE, C1S
43prednisolone44 28 1112.8ITGB2, KITLG, RNASE3, IGHE
44estrogen4410.7RNASE3
45licofelone4410.7PTGS1, ALOX5
46actinomycin d4410.6PTGS1, KIT, PRG2, IGHE, KITLG
47mizolastine4410.6HRH1, ALOX5
4815hpete4410.5ALOX5, PTGS1
4915-hydroperoxyeicosatetraenoic acid4410.4ALOX5, PTGS1
50quinacrine44 1111.3ALOX5, PTGS1, HNMT

GO Terms for genes affiliated with Urticaria

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16Gene Ontology
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Cellular components related to Urticaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7ENPP3, KITLG, CMA1, RNASE3, IGHE, PRG2

Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.9FCER1A, C1S, NLRP3, ITGB2, IGHE, KITLG
2leukotriene biosynthetic processGO:01937010.7ALOX5, FCER1A, LTC4S
3germ cell programmed cell deathGO:03523410.7KIT, KITLG
4arachidonic acid metabolic processGO:01936910.7LTC4S, PTGS1, ALOX5
5Fc-epsilon receptor signaling pathwayGO:03809510.7FCER1A, KIT, KITLG, IGHE
6lipoxin metabolic processGO:200130010.5ALOX5, LTC4S
7leukotriene metabolic processGO:00669110.5ALOX5, LTC4S
8lipoxygenase pathwayGO:01937210.4LTC4S, ALOX5
9inflammatory responseGO:00695410.3KIT, HRH1, ITGB2, NLRP3

Products for genes affiliated with Urticaria

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  • Antibodies
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Sources for Urticaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet