MCID: URT039
MIFTS: 61

Urticaria malady

Summaries for Urticaria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urticaria (from the Latin urtica, nettle,) commonly referred to as hives, is a kind of skin rash notable... more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Lymphocyte Signaling and Fc epsilon receptor (FCERI) signaling. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds histamine and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and thyroid, and related mouse phenotypes are immune system and cardiovascular system.

Aliases & Classifications for Urticaria

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

urticaria 8 10 44 60


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Disease Ontology8 DOID:1555
ICD9CM27 708.8
MeSH34 D014581

Related Diseases for Urticaria

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17GeneCards, 18GeneDecks
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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa31.6KIT, KITLG
2angioedema31.0C1S, HNMT, IGHE, LTC4S, RNASE3, HRH1
3dermatitis30.6NLRP3, ITGB2, IGHE, CMA1, ALOX5
4asthma30.5RNASE3, ALOX5
5rhinitis30.4IGHE, PRG2, RNASE3, HRH1, TPT1, PTGS1
6systemic mastocytosis30.4KITLG, KIT
7allergic rhinitis30.4IGHE, RNASE3, HRH1, ALOX5
8skin disease30.3HRH1, RNASE3, IGHE, ITGB2
9leukemia30.3ITGB2, PRG2, LTC4S, RNASE3, HRH1, KITLG
10atopic dermatitis30.3PRG2, IGHE, RNASE3, HRH1, CMA1, KITLG
11dermatographia30.3IGHE, PRG2
12psoriasis30.3ITGB2, RNASE3, CMA1, ALOX5
13allergic asthma30.2ITGB2, IGHE, RNASE3, HRH1, CMA1, ALOX5
14chronic rhinitis30.2HRH1, RNASE3
15vasculitis30.1PRG2, ITGB2, C1S
16melanoma29.9PRG2, HRH1, KITLG, KIT, PTGS1, ALOX5
17eosinophilia29.9ITGB2, PRG2, IGHE, RNASE3, ALOX5
18mastocytosis29.9IGHE, CMA1, KITLG, KIT
19arthritis29.9NLRP3, ITGB2, PTGS1, ALOX5
20glomerulonephritis29.9ITGB2, ALOX5
21malaria29.9TPT1, HRH1
22gastritis29.9PTGS1
23anisakiasis29.9RNASE3, IGHE
24toxocariasis29.9IGHE, RNASE3
25mast-cell leukemia29.9KIT, KITLG
26rheumatoid arthritis29.6C1S, ITGB2, PRG2, RNASE3, HRH1, PTGS1
27food allergy29.6C1S, IGHE, RNASE3, TPT1
28mast cell neoplasm29.6KIT, KITLG, CMA1, LTC4S
29conjunctivitis29.6NLRP3, IGHE, RNASE3, HRH1
30allergic conjunctivitis29.6IGHE, RNASE3, HRH1
31pneumonia29.6HRH1, PTGS1
32bullous pemphigoid29.6RNASE3, IGHE, PRG2
33polycythemia vera29.6KITLG, KIT
34eosinophilic gastroenteritis29.6IGHE
35churg-strauss syndrome29.6RNASE3
36polycythemia29.6KITLG
37cystic fibrosis29.6RNASE3
38paragonimiasis29.6IGHE
39myeloma29.6ITGB2, IGHE, KITLG
40cholinergic urticaria10.8
41allergic urticaria10.6
42thyroiditis10.5
43cold contact urticaria10.5
44schnitzler syndrome10.4
45familial cold autoinflammatory syndrome10.3
46aquagenic urticaria10.3
47cutaneous mastocytosis10.3
48autoimmune thyroiditis10.3
49hypohidrosis10.3
50muckle-wells syndrome10.3

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Clinical Features for Urticaria

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Genetic Tests for Urticaria

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Anatomical Context for Urticaria

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32MalaCards
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MalaCards organs/tissues related to Urticaria:

32
Skin, Testes, Thyroid, Bone, T cells, Bone marrow, Endothelial, Lung, B cells, Eye, Monocytes, Tonsil, Whole blood, Prostate, Smooth muscle, Small intestine, Colon, Breast

Animal Models for Urticaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urticaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8CPN1, NLRP3, ITGB2, PRG2, IGHE, LTC4S
2MP:000538510.7LTC4S, KITLG, KIT, FCER1A, TCAP, PTGS1
3MP:000539710.6NLRP3, ITGB2, PRG2, IGHE, HRH1, KITLG
4MP:000537610.4HRH1, IGHE, ITGB2, NLRP3, KITLG, KIT

Publications for Urticaria

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50PubMed
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Articles related to Urticaria:

(show top 50)    (show all 1417)
idTitleAuthorsYear
1
Efficacy and safety of sulfasalazine in patients with chronic idiopathic urticaria. (24331396)
2014
2
Randomized, double-blind, placebo-controlled study of safety and efficacy of miltefosine in antihistamine-resistant chronic spontaneous urticaria. (22928719)
2013
3
Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria. (24034140)
2013
4
The role of focal infections in the pathogenesis of psoriasis and chronic urticaria. (24278052)
2013
5
Autologous serum skin test as a diagnostic aid in chronic idiopathic urticaria. (23691344)
2013
6
The impact of chronic urticaria on the quality of life in Indian patients. (22615506)
2012
7
Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation. (22242678)
2012
8
Acute urticaria associated with thyroid papillary carcinoma: a case report. (23197912)
2012
9
Successful treatment of systemic cold contact urticaria with etanercept in a patient with psoriasis. (22212112)
2012
10
Contact urticaria to raw arugula and parsley. (21530883)
2011
11
Gastroesophageal reflux disease accompanying urticaria pigmentosa. (22185927)
2011
12
Chronic urticaria and IgG paraproteinaemia: unusual spectrum of Schnitzler Syndrome. (21717039)
2011
13
Urticaria multiforme--a case report. (21793883)
2011
14
Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy. (18186820)
2008
15
Increased concentration of platelet-derived chemokines in serum of patients with delayed pressure urticaria. (18632422)
2008
16
Chronic urticaria and monoclonal IgM gammopathy (Schnitzler syndrome): report of 11 cases treated with pefloxacin. (17709664)
2007
17
Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines. (16716168)
2006
18
Serum-induced basophil CD63 expression by means of a tricolour flow cytometric method for the in vitro diagnosis of chronic urticaria. (16918509)
2006
19
Responsiveness to autologous sweat and serum in cholinergic urticaria classifies its clinical subtypes. (16083796)
2005
20
Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria. (16297195)
2005
21
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. (11992256)
2002
22
Case 4. Chronic urticaria due to strongyloidiasis. (11952686)
2002
23
Urticaria and angioedema induced by COX-2 inhibitors. (11842312)
2002
24
Extraction of IgE-binding components of Helicobacter pylori by immunoblotting analysis in chronic urticaria patients. (11752878)
2001
25
Chronic urticaria associated with chronic myelomonocytic leukemia. (11206941)
2000
26
Cyclosporin A therapy for severe solar urticaria. (9361130)
1997
27
Treatment of aquagenic urticaria with PUVA and astemizole. (8996279)
1997
28
Plasma exchange therapy for solar urticaria. (8763431)
1996
29
Urticaria pigmentosa and juvenile xanthogranuloma: case report and brief review of the literature. (9122068)
1996
30
Urticaria, arthralgia, and nephropathy without amyloidosis: another variant of the Muckle-Wells syndrome? (8737977)
1996
31
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)
1994
32
Edward Nettleship (1845-1913) and the description of urticaria pigmentosa. (8169028)
1994
33
Urticaria, nephritis, and pseudotumor cerebri. (2323023)
1990
34
Ganglioneuroblastoma and urticaria by physical agents. (2368174)
1990
35
Cellular infiltrate and deposited material in solar urticaria. (2082977)
1990
36
Mechanisms for hyperpigmentation in postinflammatory pigmentation, urticaria pigmentosa and sunburn. (2550287)
1989
37
Morphological characterization of the somatostatin-immunoreactive dendritic skin cells in urticaria pigmentosa patients by computerized image analysis. (2860719)
1985
38
Adult-onset urticaria pigmentosa and systemic mast cell disease. (4072966)
1985
39
Solar urticaria. (3977370)
1985
40
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984
41
Exercise-induced anaphylaxis as a manifestation of cholinergic urticaria. (6169753)
1981
42
Elevated blood histamine levels and mast cell degranulation in solar urticaria. (7356907)
1980
43
An electron microscopic study of the degranulation of mast cell granules in urticaria pigmentosa. (5907059)
1966
44
Histamine formation in urticaria pigmentosa. (13762303)
1961
45
Urticaria pigmentosa with systemic lesions and otosclerosis. (14415943)
1960
46
Urticaria pigmentosa; solitary lesions occurring in a mother and her daughter. (13486943)
1958
47
Papular URTICARIA. (13081168)
1953
48
Urticaria pigmentosa. (15433453)
1950
49
Urticaria Pigmentosa. (19984305)
1925
50
Urticaria Pigmentosa in an Adult. (19982867)
1923

Genetic Variations for Urticaria

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Expression for genes affiliated with Urticaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

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4Cell Signaling Technology, 53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Urticaria

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.3LTC4S, IGHE, PRG2, ITGB2, HNMT, HRH1
2calcium44 49 11 2414.2CMA1, KIT, KITLG, C1S, ITGB2, PRG2
3aspirin44 49 28 2414.1HNMT, PTGS1, LTC4S, RNASE3, HRH1, KITLG
4pgd24411.1ALOX5, PTGS1, KITLG, RNASE3, LTC4S, IGHE
5dexamethasone44 49 28 1114.1ITGB2, LTC4S, RNASE3, PTGS1, HRH1, KITLG
6ltc44411.1RNASE3, ALOX5, LTC4S, PRG2, ITGB2, PTGS1
7nitric oxide44 11 2413.1RNASE3, PRG2, ITGB2, HRH1, KITLG, PTGS1
8allergens4411.1HRH1, RNASE3, ENPP3, TPT1, PRG2, IGHE
9lactate4411.1IGHE, ITGB2, TPT1, PTGS1, KIT, KITLG
10heparin44 28 11 2414.1ALOX5, CMA1, RNASE3, PRG2, ITGB2, C1S
11montelukast44 49 28 1114.1ALOX5, PTGS1, RNASE3, LTC4S, IGHE
12anti-histamine4411.1IGHE, RNASE3, HRH1, ALOX5, KITLG
13leukotriene b444 59 2413.0PTGS1, RNASE3, ITGB2, LTC4S, ALOX5
14nedocromil sodium4411.0ALOX5, RNASE3, HRH1, TPT1, IGHE
15indomethacin44 59 28 1114.0ITGB2, PRG2, ALOX5, IGHE, PTGS1, HRH1
16lte44411.0ALOX5, PTGS1, LTC4S, RNASE3
17ltd44411.0ALOX5, RNASE3, LTC4S, HRH1
18azelastine44 1112.0ALOX5, IGHE, HRH1, RNASE3
19budesonide44 49 1113.0RNASE3, KITLG, IGHE, PTGS1
20salbutamol44 49 28 11 2415.0KITLG, RNASE3, IGHE, ITGB2
21txb24411.0RNASE3, ALOX5, PTGS1, C1S
22fmlp4411.0RNASE3, PRG2, ITGB2, ALOX5, TPT1
23diethylcarbamazine44 1112.0ALOX5, IGHE, PTGS1
24arachidonic acid44 28 11 2414.0TPT1, ALOX5, PTGS1, KITLG, HRH1, LTC4S
25vegf4411.0PTGS1, KIT, RNASE3, IGHE, ITGB2, ALOX5
26dmso4411.0LTC4S, KITLG, PTGS1, ITGB2, ALOX5
27capsaicin44 2811.9RNASE3, CMA1, HRH1, IGHE
28sodium cromoglycate4410.9RNASE3, IGHE, HRH1
29toluene diisocyanate4410.9RNASE3, HNMT, IGHE
30zafirlukast44 28 1112.9RNASE3, ALOX5, PTGS1
31arginine4410.9ITGB2, C1S, IGHE, CPN1, PRG2, ALOX5
32cetirizine44 28 11 2413.9RNASE3, IGHE, HRH1
33loratadine44 11 2412.9IGHE, HRH1, RNASE3
34zileuton59 44 28 1113.9LTC4S, PTGS1, ALOX5
35rantes4410.9HRH1, KITLG, ITGB2, RNASE3, TPT1
36ketotifen44 1111.9HRH1, RNASE3, IGHE
37antimycin a4410.9RNASE3, ALOX5, PRG2
38epinephrine44 11 2412.9ALOX5, IGHE, RNASE3, KITLG, HRH1
39diphenhydramine44 28 2 11 2414.8HNMT, PTGS1, HRH1
40pge24410.8LTC4S
41aspartate4410.8IGHE, ITGB2, HRH1, ALOX5
42latex4410.8KITLG, RNASE3, IGHE, C1S
43prednisolone44 28 1112.8ITGB2, KITLG, RNASE3, IGHE
44estrogen4410.7RNASE3
45licofelone4410.7PTGS1, ALOX5
46actinomycin d4410.6PTGS1, KIT, PRG2, IGHE, KITLG
47mizolastine4410.6HRH1, ALOX5
4815hpete4410.5ALOX5, PTGS1
4915-hydroperoxyeicosatetraenoic acid4410.4ALOX5, PTGS1
50quinacrine44 1111.3ALOX5, PTGS1, HNMT

GO Terms for genes affiliated with Urticaria

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16Gene Ontology
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Cellular components related to Urticaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7ENPP3, KITLG, CMA1, RNASE3, IGHE, PRG2

Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.9FCER1A, C1S, NLRP3, ITGB2, IGHE, KITLG
2leukotriene biosynthetic processGO:01937010.7ALOX5, FCER1A, LTC4S
3germ cell programmed cell deathGO:03523410.7KIT, KITLG
4arachidonic acid metabolic processGO:01936910.7LTC4S, PTGS1, ALOX5
5Fc-epsilon receptor signaling pathwayGO:03809510.7FCER1A, KIT, KITLG, IGHE
6lipoxin metabolic processGO:200130010.5ALOX5, LTC4S
7leukotriene metabolic processGO:00669110.5ALOX5, LTC4S
8lipoxygenase pathwayGO:01937210.4LTC4S, ALOX5
9inflammatory responseGO:00695410.3KIT, HRH1, ITGB2, NLRP3

Products for genes affiliated with Urticaria

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Sources for Urticaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet