MCID: URT039
MIFTS: 61

Urticaria malady

Summaries for Urticaria

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Urticaria (from the Latin urtica, nettle,) commonly referred to as hives, is a kind of skin rash notable... more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Lymphocyte Signaling and Fc epsilon receptor (FCERI) signaling. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds histamine and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are immune system and cardiovascular system.

Aliases & Classifications for Urticaria

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

urticaria 8 10 45 61


External Ids:

Disease Ontology8 DOID:1555
ICD9CM27 708.8
MeSH35 D014581

Related Diseases for Urticaria

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa31.6KIT, KITLG
2angioedema31.1ALOX5, PTGS1, HRH1, RNASE3, LTC4S, IGHE
3mastocytosis30.9KITLG, KIT, CMA1, IGHE
4asthma30.5ALOX5, RNASE3
5systemic mastocytosis30.5KITLG, KIT
6allergic rhinitis30.4HRH1, IGHE, ALOX5, RNASE3
7atopic dermatitis30.3PRG2, IGHE, HRH1, KITLG, RNASE3, CMA1
8allergic asthma30.2IGHE, CMA1, RNASE3, ITGB2, ALOX5, TPT1
9chronic rhinitis30.2RNASE3, HRH1
10vasculitis30.1PRG2, ITGB2, C1S
11atopy30.0PRG2, LTC4S, TPT1, CMA1, RNASE3, IGHE
12arthritis29.9ALOX5, NLRP3, PTGS1, ITGB2
13anisakiasis29.9RNASE3, IGHE
14toxocariasis29.9IGHE, RNASE3
15mast-cell leukemia29.9KIT, KITLG
16sinusitis29.7RNASE3, ALOX5, IGHE, LTC4S, PRG2
17hypereosinophilic syndrome29.7RNASE3, IGHE, KIT, PRG2
18allergic conjunctivitis29.7IGHE, HRH1, RNASE3
19bullous pemphigoid29.7PRG2, IGHE, RNASE3
20polycythemia vera29.7KIT, KITLG
21eosinophilic gastroenteritis29.7IGHE
22churg-strauss syndrome29.7RNASE3
23cystic fibrosis29.7RNASE3
24paragonimiasis29.7IGHE
25solar urticaria10.9
26cholinergic urticaria10.8
27papular urticaria10.7
28aquagenic urticaria10.6
29allergic urticaria10.6
30cold contact urticaria10.5
31schnitzler syndrome10.4
32genetic urticaria10.4
33hypohidrosis10.3
34muckle-wells syndrome10.3
35nodular urticaria pigmentosa10.3
36familial cold autoinflammatory syndrome10.3
37n syndrome10.2
38exercise induced anaphylaxis10.2
39adult-onset still's disease10.2
40hepatitis a10.2
41thyroiditis10.2
42vibratory urticaria10.1
43cutis laxa10.1
44follicular mucinosis10.1
45osteoporosis10.1
46wells syndrome10.1
47hepatitis c10.0
48autoimmune thyroiditis10.0
49juvenile xanthogranuloma10.0
50alexithymia10.0

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Clinical Features for Urticaria

Genetic Tests for Urticaria

Anatomical Context for Urticaria

Sources:
33MalaCards
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MalaCards organs/tissues related to Urticaria:

33
Skin, Brain, Lung, Bone marrow, Whole blood, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Thyroid, Breast, Prostate, Tonsil, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Urticaria or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Urticaria

Sources:
51PubMed
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Articles related to Urticaria:

(show top 50)    (show all 1512)
idTitleAuthorsYear
1
Urticaria and angioedema in pregnancy and lactation. (24262695)
2014
2
Immunologic contact urticaria. (24262696)
2014
3
Delayed onset urticaria in depressive patients with bupropion prescription: a nationwide population-based study. (24244611)
2013
4
Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs. (23763970)
2013
5
Anisakis simplex hypersensitivity is associated with chronic urticaria in endemic areas. (23095317)
2013
6
Chronic urticaria and autoimmunity. (24305753)
2013
7
Seroprevalence of IgG anti-Toxocara canis antibodies and anti-Fasciola sp. antibodies in patients with urticaria. (24045514)
2013
8
Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria. (23717010)
2013
9
CTLA-4 polymorphism in the pathogenesis of chronic spontaneous autoreactive urticaria. (23597501)
2013
10
A long term case series study of the effect of omalizumab on chronic spontaneous urticaria. (23717021)
2013
11
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
12
Cost-intensive, time-consuming, problematical? How physicians in private practice experience the care of urticaria patients. (22111985)
2012
13
Reticular variant of mid-dermal elastolysis accompanied by persistent urticarial lesions. (22724522)
2012
14
Long-term complete resolution of severe chronic idiopathic urticaria after dapsone treatment. (22126213)
2012
15
Contact urticaria to raw arugula and parsley. (21530883)
2011
16
Urticaria pigmentosa after treatment with TNF antagonists: a case report. (22184778)
2011
17
Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. (21966608)
2011
18
Exanthem with cryopyrin associated periodic syndromes and consideration of IL-1 targeted therapy for neutrophilic predominant urticaria. (20657165)
2010
19
HLA status in patients with chronic spontaneous urticaria. (20559009)
2010
20
Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticaria. (19485983)
2009
21
Therapeutic effect of anti-anaphylaxis granule on chronic urticaria and its impact on serum levels of RANTES]. (20073227)
2009
22
Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs. (17304885)
2007
23
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
24
Circulating stem cell factor in patients with chronic idiopathic urticaria. (12877454)
2003
25
An infant with urticaria pigmentosa and rickets. (12027094)
2002
26
Immune profiles of patients with chronic idiopathic urticaria. (12037402)
2002
27
Chronic urticaria: impact of allergic inflammation. (12492725)
2002
28
Autoimmunity in chronic urticaria and urticarial vasculitis. (11892055)
2001
29
Identification of a locus on chromosome 1q44 for familial cold urticaria. (10741953)
2000
30
Inhibitory effect of heparin on skin reactivity to autologous serum in chronic idiopathic urticaria. (10359897)
1999
31
Urticaria-like follicular mucinosis in a young female patient. (9228231)
1997
32
Double-blind crossover study of high-dose cetirizine in cholinergic urticaria. (8993958)
1996
33
Plasma exchange therapy for solar urticaria. (8763431)
1996
34
Urticaria pigmentosa: a review of 67 pediatric cases. (8041646)
1994
35
Chronic idiopathic urticaria: possible contribution of histamine-releasing factor to pathogenesis. (7687607)
1993
36
Pruritic pigmented papules posing permanent problems. Urticaria pigmentosa (UP) with secondary anetoderma. (1739279)
1992
37
Mechanism of action of doxepin in the treatment of chronic urticaria. (2141000)
1990
38
Urticaria pigmentosa: an anesthetic challenge. (1971752)
1990
39
Solar urticaria--effective treatment by plasmapheresis. (3690881)
1987
40
Papular urticaria and immune complexes. (3973134)
1985
41
Urticaria, vasculitis, hypocomplementemia, and immune-complex glomerulonephritis. (6460484)
1982
42
Cholinergic urticaria. A seasonal disease. (7247588)
1981
43
Tests to establish the diagnosis in cholinergic urticaria. (626713)
1978
44
Bullous papular urticaria. (25745)
1978
45
Urticaria pigmentosa and factitious urticaria. Direct evidence for release of histamine and other smooth muscle-contracting agents in dermographic skin. (4191715)
1970
46
A histochemical study of urticaria pigmentosa. (6003982)
1966
47
ELECTRONMICROSCOPIC OBSERVATIONS OF MAST CELLS IN THE LESIONS OF URTICARIA PIGMENTOSA. (14071304)
1963
48
Bullous urticaria pigmentosa: report of an unusual case. (13180029)
1954
49
Urticaria pigmentosa treated with toluidine blue. (14922974)
1952
50
Urticaria Pigmentosa, Adult Type. (19992934)
1944

Genetic Variations for Urticaria

Expression for genes affiliated with Urticaria

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

Sources:
4Cell Signaling Technology, 54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 50PharmGKB
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Compounds for genes affiliated with Urticaria

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 2BitterDB
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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2413.3LTC4S, IGHE, PRG2, ITGB2, HNMT, HRH1
2calcium45 50 11 2414.2CMA1, KIT, KITLG, C1S, ITGB2, PRG2
3aspirin45 50 29 2414.1HNMT, PTGS1, LTC4S, RNASE3, HRH1, KITLG
4pgd24511.1ALOX5, PTGS1, KITLG, RNASE3, LTC4S, IGHE
5dexamethasone45 50 29 1114.1ITGB2, LTC4S, RNASE3, PTGS1, HRH1, KITLG
6ltc44511.1RNASE3, ALOX5, LTC4S, PRG2, ITGB2, PTGS1
7nitric oxide45 11 2413.1RNASE3, PRG2, ITGB2, HRH1, KITLG, PTGS1
8allergens4511.1HRH1, RNASE3, ENPP3, TPT1, PRG2, IGHE
9lactate4511.1IGHE, ITGB2, TPT1, PTGS1, KIT, KITLG
10heparin45 29 11 2414.1ALOX5, CMA1, RNASE3, PRG2, ITGB2, C1S
11montelukast45 50 29 1114.1ALOX5, PTGS1, RNASE3, LTC4S, IGHE
12anti-histamine4511.1IGHE, RNASE3, HRH1, ALOX5, KITLG
13leukotriene b445 60 2413.0PTGS1, RNASE3, ITGB2, LTC4S, ALOX5
14nedocromil sodium4511.0ALOX5, RNASE3, HRH1, TPT1, IGHE
15indomethacin45 60 29 1114.0ITGB2, PRG2, ALOX5, IGHE, PTGS1, HRH1
16lte44511.0ALOX5, PTGS1, LTC4S, RNASE3
17ltd44511.0ALOX5, RNASE3, LTC4S, HRH1
18azelastine45 1112.0ALOX5, IGHE, HRH1, RNASE3
19budesonide45 50 1113.0RNASE3, KITLG, IGHE, PTGS1
20salbutamol45 50 29 11 2415.0KITLG, RNASE3, IGHE, ITGB2
21txb24511.0RNASE3, ALOX5, PTGS1, C1S
22fmlp4511.0RNASE3, PRG2, ITGB2, ALOX5, TPT1
23diethylcarbamazine45 1112.0ALOX5, IGHE, PTGS1
24arachidonic acid45 29 11 2414.0TPT1, ALOX5, PTGS1, KITLG, HRH1, LTC4S
25vegf4511.0PTGS1, KIT, RNASE3, IGHE, ITGB2, ALOX5
26dmso4511.0LTC4S, KITLG, PTGS1, ITGB2, ALOX5
27capsaicin45 2911.9RNASE3, CMA1, HRH1, IGHE
28sodium cromoglycate4510.9RNASE3, IGHE, HRH1
29toluene diisocyanate4510.9RNASE3, HNMT, IGHE
30zafirlukast45 29 1112.9RNASE3, ALOX5, PTGS1
31arginine4510.9ITGB2, C1S, IGHE, CPN1, PRG2, ALOX5
32cetirizine45 29 11 2413.9RNASE3, IGHE, HRH1
33loratadine45 11 2412.9IGHE, HRH1, RNASE3
34zileuton60 45 29 1113.9LTC4S, PTGS1, ALOX5
35rantes4510.9HRH1, KITLG, ITGB2, RNASE3, TPT1
36ketotifen45 1111.9HRH1, RNASE3, IGHE
37antimycin a4510.9RNASE3, ALOX5, PRG2
38epinephrine45 11 2412.9ALOX5, IGHE, RNASE3, KITLG, HRH1
39diphenhydramine45 29 2 11 2414.8HNMT, PTGS1, HRH1
40pge24510.8LTC4S
41aspartate4510.8IGHE, ITGB2, HRH1, ALOX5
42latex4510.8KITLG, RNASE3, IGHE, C1S
43prednisolone45 29 1112.8ITGB2, KITLG, RNASE3, IGHE
44estrogen4510.7RNASE3
45licofelone4510.7PTGS1, ALOX5
46actinomycin d4510.6PTGS1, KIT, PRG2, IGHE, KITLG
47mizolastine4510.6HRH1, ALOX5
4815hpete4510.5ALOX5, PTGS1
4915-hydroperoxyeicosatetraenoic acid4510.4ALOX5, PTGS1
50quinacrine45 1111.3ALOX5, PTGS1, HNMT

GO Terms for genes affiliated with Urticaria

Sources:
16Gene Ontology
See all sources

Cellular components related to Urticaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7ENPP3, KITLG, CMA1, RNASE3, IGHE, PRG2

Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.9IGHE, C1S, NLRP3, ITGB2, KITLG, FCER1A
2leukotriene biosynthetic processGO:01937010.7ALOX5, FCER1A, LTC4S
3germ cell programmed cell deathGO:03523410.7KITLG, KIT
4arachidonic acid metabolic processGO:01936910.7LTC4S, PTGS1, ALOX5
5Fc-epsilon receptor signaling pathwayGO:03809510.7FCER1A, KIT, KITLG, IGHE
6lipoxin metabolic processGO:200130010.5ALOX5, LTC4S
7leukotriene metabolic processGO:00669110.5LTC4S, ALOX5
8lipoxygenase pathwayGO:01937210.4LTC4S, ALOX5
9inflammatory responseGO:00695410.3NLRP3, ITGB2, HRH1, KIT

Products for genes affiliated with Urticaria

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Urticaria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet