Urticaria malady

Wikipedia: Urticaria (from the Latin urtica, nettle , commonly referred to as hives, is a kind of skin rash notable...⁴⁴ more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Lymphocyte Signaling and RAR-Gamma-RXR-Alpha Degradation. The drugs chlorpheniramine and loratadine and the compounds budesonide and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and monocytes, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

urticaria 6 8 32 43

Diseases related to urticaria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 981)

id	Related Disease	Score	Top Affiliating Genes
1	urticaria pigmentosa	34.1	KIT, KITLG, CMA1, IL2RA, TCAP
2	angioedema	32.8	SERPINC1, SERPINA4, SERPING1, SERPINB1, XPNPEP2, MS4A2
3	cholinergic urticaria	32.7	CHRM3, LATS2, FLAD1, HRH1, POLK
4	asthma	31.6	ALOX5, CYSLTR1, RNASE3
5	allergic rhinitis	31.2	SELE, VCAM1, IL13, IL4, IGES, IGHE
6	muckle-wells syndrome	30.9	IL1R1, IL1RAPL2, IL3, IL8, CASP1, TNFRSF1A
7	familial cold autoinflammatory syndrome	30.4	IL1R1, IL1RAPL2, CASP1, NLRP3
8	mastocytosis	29.9	KIT, KITLG, CMA1, CD63, FCER2, IL13
9	wells syndrome	28.8	IL1R1, IL1RAPL2, IL3, IL8, CASP1, TNFRSF1A
10	schnitzler syndrome	28.6	CD40LG, IL18, IL1A, IL1R1, IL1RAPL2, TNF
11	mast cell neoplasm	28.5	KIT, KITLG, CMA1, IL3, LTC4S, HDC
12	cystic echinococcosis	28.3	IL2RA, IGHE, HLA-B, HLA-DRB1
13	cryopyrin-associated periodic syndrome	28.2	IL1R1, IL1RAPL2, NLRP3
14	autoimmune thyroiditis	27.9	ITGB2, IL2RA, IL4, IFNG, ICAM1, CALCA
15	alpha-1-antichymotrypsin deficiency	27.2	SERPINC1, SERPINF2, CMA1
16	fascioliasis	25.8	SELE, INS, IL10, IFNG, TNF, RNASE3
17	was-related disorders	25.7	LPL, INS, IL2RA, IL8, CALCA, HRAS
18	atopic dermatitis	25.5	KITLG, SELE, SELP, VCAM1, CMA1, MS4A2
19	eczema	24.6	SELE, CMA1, MS4A2, CD79A, CD40LG, FCER1A
20	macroglobulinemia	24.2	KITLG, VEGFA, LPL, CD79A, CD40LG, IL10
21	immunodeficiency	23.1	CD79A, CD40LG, ITGB2, ITIH4, GZMB, INS
22	rhinitis	22.4	KITLG, SELE, SERPINB1, VEGFA, VCAM1, CMA1
23	blindness	19.7	SELE, SELP, SERPINC1, VEGFA, LPL, CHRM3
24	dermatitis	18.9	KITLG, SELE, SELP, SERPING1, VEGFA, VCAM1
25	vasculitis	18.3	SELE, SELP, SERPINC1, SERPING1, SERPINB1, VEGFA
26	thyroiditis	18.0	KIT, KITLG, SELE, SELP, SERPINC1, SERPINB1
27	bronchial asthma	17.7	KITLG, SELE, SELP, VEGFA, VCAM1, CMA1
28	melanoma	16.9	KIT, KITLG, SELE, SELP, VEGFA, LPL
29	allergic conjunctivitis	14.2	IL13, IL4, CCL11, IGHE, HRH1, RNASE3
30	kimura disease	14.2	KIT, IL13, IL4, CCL11, IGES, IGHE
31	eosinophilic gastroenteritis	14.1	CCL11, IGES, IGHE, RNASE3, PRG2, CSN1S1
32	chronic sphenoidal sinusitis	14.1	IL13, IL4, IL8, CCL11, IGES, IGHE
33	food allergy	14.1	IL13, IL4, CCL11, IGES, IGHE, TPT1
34	gastroesophageal reflux disease	14.0	IL8, CCL2, CCL11, HRH2, PTGS2, PTGS1
35	eosinophilic pneumonia	14.0	IL13, IL3, CCL11, IGHE, RNASE3
36	gamma chain deficiency	14.0	KITLG, IL13, IL2RA, IL2RB, IL4
37	helminthiasis	14.0	IL13, IGHE, RNASE3
38	stomach disease	14.0	HRH2, PTGS2, PTGS1, COX5A
39	intrinsic asthma	14.0	FCER2, IL3, IL4, IGES, IGHE, RNASE3
40	bronchitis	14.0	SERPINB1, IL8, CCL11, IGHE, RNASE3, PRTN3
41	mycetoma	13.9	IL8, IFNG, TPT1, CSN1S1
42	pulmonary eosinophilia	13.9	IL13, IL3, IL4, IL8, CCL11, CCL3
43	mast-cell leukemia	13.9	KIT, KITLG, CCL2, CCL3
44	berylliosis	13.9	IL2RB, IFNG, HLA-DPB1, HLA-DRB1
45	ulceration of vulva	13.9	IL2RB, HRH2, PTGS2, PTGS1, COX5A, RNASE3
46	lipoid nephrosis	13.9	CD79A, FCER2, IL13, IL2RB, CCL2
47	plummer's disease	13.9	SELE, ICAM1, TPO, TG
48	asthma and nasal polyps	13.9	IL3, PTGS2, PTGS1
49	pemphigoid gestationis	13.9	CCL11, HLA-DRB1, COL17A1
50	aseptic meningitis	13.9	IL1R1, CCL3, NLRP3, SOD2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acrivastine, astemizole, azatadine, azatadine maleate, bromodiphenhydramine, bromodiphenhydramine hydrochloride, cetirizine, cetirizine hydrochloride, chlorpheniramine, chlorpheniramine maleate, chlorpheniramine polistirex, chlorpheniramine tannate, cimetidine, cimetidine hydrochloride, clemastine, clemastine fumarate, cyproheptadine, cyproheptadine hydrochloride, cyproheptadine hydrochloride monohydrate, desloratadine, dexchlorpheniramine, dexchlorpheniramine maleate, diphenhydramine, diphenhydramine citrate, diphenhydramine hydrochloride, famotidine, fexofenadine, fexofenadine hydrochloride, loratadine, methdilazine, methdilazine hydrochloride, nizatidine, phenindamine, phenindamine tartrate, phenyltoloxamine, phenyltoloxamine citrate, phenyltoloxamine dihydrogen citrate, phenyltoloxamine resin complex, trimeprazine, trimeprazine tartrate, tripelennamine, tripelennamine citrate, tripelennamine hydrochloride

MalaCards organs/tissues related to urticaria:

²²

MGI Mouse Phenotypes related to urticaria:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	CRHR1, IFNG, IL2RB, CD40LG, CHRM3
2	hematopoietic system phenotype	MP:0005397	9.9	PTPN22, DSG3, TG, TGM2, PRG2, SOD2
3	renal/urinary system phenotype	MP:0005367	9.6	PTGS1, PLCG2, NLRP3, TGM2, SOD2, HRAS
4	respiratory system phenotype	MP:0005388	9.6	ADORA3, INPPL1, CALCA, PTPN22, TBXA2R, CYSLTR1
5	skeleton phenotype	MP:0005390	8.6	ALOX5AP, CALCA, HRAS, TNFRSF1A, PTGS2, SYK
6	no phenotypic analysis	MP:0003012	8.5	ADRB2, SYK, TGM2, PTGS2, PTGDR2, HLA-C
7	liver/biliary system phenotype	MP:0005370	8.2	HRH1, PTPN22, NLRP3, SYK, PRL, SOD1
8	integument phenotype	MP:0010771	8.1	F2, CALCA, HRAS, TNFRSF1A, PTGS1, PLCG2
9	digestive/alimentary phenotype	MP:0005381	8.0	CCL3, GPX1, IFNG, F2, CASP1, HRH2
10	growth/size phenotype	MP:0005378	7.8	PTPN22, TPT1, TPO, HRH1, HRAS, F3
11	adipose tissue phenotype	MP:0005375	7.2	PTGS2, ACE, DSG3, TGFB1, SOD2, ADRB2
12	reproductive system phenotype	MP:0005389	7.1	PTGS2, PTGS1, TBXA2R, NLRP3, COL17A1, TGFB1
13	tumorigenesis	MP:0002006	7.0	PTGS2, TNFRSF1A, TNF, HRAS, CASP1, PTGS1
14	nervous system phenotype	MP:0003631	7.0	HRH2, HLA-C, HLA-DQB1, TNFRSF1A, NRL, NGF
15	behavior/neurological phenotype	MP:0005386	6.9	CRHR1, PTGS1, TNFRSF1A, HLA-DQB1, HLA-C, HRH2
16	immune system phenotype	MP:0005387	6.9	IFNG, SERPINB1, CMA1, MS4A2, CD79A, GZMB
17	mortality/aging	MP:0010768	6.4	C5AR1, SYK, TGM2, TBXA2R, CRHR1, PLCG2
18	muscle phenotype	MP:0005369	6.3	PTGS2, TNFRSF1A, TNF, HLA-DQB1, PTGS1, TGFB1
19	vision/eye phenotype	MP:0005391	5.6	TNFRSF1A, TNF, F3, ICAM1, IFNG, PTGS2
20	cellular phenotype	MP:0005384	4.0	TPT1, TNF, TNFRSF1A, PTGS2, PTPN22, PTGS1
21	homeostasis/metabolism phenotype	MP:0005376	3.4	CRP, PLCG2, NLRP3, PF4, KLKB1, TG
22	cardiovascular system phenotype	MP:0005385	3.3	CHRM3, KITLG, SELE, SELP, SERPINC1, SERPING1

Articles related to urticaria:

(show top 50)    (show all 208)

id	Title	Authors	Year	Affiliating Genes
1	Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenas e-activating protein are associated with chronic spontaneous urticaria and urin ary leukotriene E4. (21227888)	Di Lorenzo G.... Caruso C.	2011	ALOX5AP
2	Lack of a role for cross-reacting anti-thyroid antibo dies in chronic idiopathic urticaria. (20182447)	Mozena J.D.... Borish L.	2010	TPO, TG
3	Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria. (21070398)	Palikhe N.S.... Park H.S.	2010	TBXA2R
4	Serum total tryptase levels are increased in patients with active chronic urticaria. (20718781)	Ferrer M.... Schwartz L.B.	2010	TPSAB1
5	Functional variability of the adenosine A3 receptor ( ADORA3) gene polymorphism in aspirin-induced urticaria. (20716228)	Kim S.H.... Park H.S.	2010	ADORA3
6	Influence of penetrative needling of Shendao (GV 11) on the symptom score and serum IgE content in chronic urticaria patients (19916293)	Gao H.... Wu J.J.	2009	IGHE
7	Comparison of the in vivo autologous skin test with in vitro diagnostic tests for diagnosis of chronic autoimmune urticaria. (19026096)	Altrich M.L.... Altman L.C.	2009	IGHE
8	Matrix metalloproteinase-9: a novel biomarker for mon itoring disease activity in patients with chronic urticaria patients? (19317840)	Altrichter S.... Maurer M.	2009	MMP9
9	Syk-deficient basophils from donors with chronic idiopathic urticaria exhibit a spectrum of releasability. (18206515)	Vonakis B.M.... Saini S.S.	2008	SYK
10	Association of insertion/deletion polymorphism of the angiotensin-converting enzyme gene with angio-oedema accompanying chronic urticaria but not chronic urticaria without angio-oedema or the autologous serum skin test response. (18181977)	Akcali C.... Aynacioglu A.S.	2008	ACE
11	Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus. (18341658)	Lourenco F.D.... Sato M.N.	2008	IL3, ENPP3, IGHE
12	Urticaria and urticaria related skin condition/disease in children. (18700329)	Novembre E.... Vierucci A.	2008	IGHE
13	The Schnitzler syndrome: chronic urticaria and monoclonal gammopathy--an autoinflammatory syndrome? (18371052)	Eiling E.... Schwarz T.	2008	IL1R1
14	Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs. (17304885)	Muratore L.... Ferrannini A.	2007	PTGS2
15	Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide. (17291297)	Inomata N.... Ikezawa Z.	2007	PTGS2
16	Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens. (16425065)	Abdel-Naser M.B.... Sayed Ali N.M.	2006	IGHE
17	Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. (17107400)	Caproni M.... Fabbri P.	2006	SELE
18	Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria. (16650165)	Cassano N.... Vena G.A.	2006	SOD1
19	Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)	DuBuske L.M.	2005	HRH1
20	The thyroid and urticaria. (16131915)	Dreskin S.C.... Andrews K.Y.	2005	IGHE
21	Chronic urticaria with alterations of the thyroid function and thyroid peroxidase antibodies (16042134)	Fernandez Romero D.S.... Malbran A.	2005	TPO
22	The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. (15784113)	Kim S.H.... Park H.S.	2005	HLA-DQB1, HLA-DRB1, HLA-DPB1
23	Association of HLA-DRB1, DQB1 alleles with chronic urticaria. (16201295)	Chen J.... Xiong P.	2005	HLA-DQB1, HLA-DRB1
24	Is there any relationship between human leucocyte antigen class II and chronic urticaria? (chronic urticaria and HLA class II). (15227724)	Oztas P.... Soylemezoglu O.	2004	HLA-DQA1, HLA-DRB1
25	Serological detection of eotaxin, IL-4, IL-13, IFN-gamma, MIP-1alpha, TARC and IP-10 in chronic autoimmune urticaria and chronic idiopathic urticaria. (15488706)	Caproni M.... Fabbri P.	2004	IL4, IFNG, CCL11
26	Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. (15347373)	Nettis E.... Ferrannini A.	2004	CYSLTR1
27	Basophil CD63 expression assay on highly sensitized atopic donor leucocytes-a useful method in chronic autoimmune urticaria. (15327546)	Gyimesi E.... Szegedi A.	2004	IGHE
28	Drug-induced chronic urticarias (12843807)	Mathelier-Fusade P.	2003	KNG1
29	Circulating stem cell factor in patients with chronic idiopathic urticaria. (12877454)	Asero R.... Riboldi P.	2003	KITLG, TPT1
30	Chronic idiopathic urticaria: a family study. (12197577)	Asero R.	2002	TPT1
31	NSAID-induced urticaria and angioedema: a reappraisal of its clinical management. (12444802)	SA!nchez-Borges M.... Caballero-Fonseca F.	2002	PTGS1, PTGS2, ALOX5
32	Increased plasma eotaxin in atopic dermatitis and acute urticaria in infants and children. (11576081)	Hossny E.... Bakr S.	2001	CCL11
33	Chronic urticaria and Helicobacter pylori. (11428745)	Gala Ortiz G.... Losada Cosmes E.	2001	IGHE
34	Mechanisms of autoimmune activation of basophils in c hronic urticaria. (11398085)	Kikuchi Y.... Kaplan A.P.	2001	CCL2
35	Conditional autoantibodies in urticaria patients: a unifying hypothesis. (11764305)	Stadler B.M.... Miescher S.	2001	IGHE
36	Helicobacter pylori infection affects eosinophilic cationic protein in the gastric juice of patients with idiopathic chronic urticaria. (11385290)	Ojetti V.... Gasbarrini A.	2001	RNASE3
37	The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. (10233264)	Sabroe R.A.... Greaves M.W.	1999	IGHE
38	Anti-Fc(episilon)RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria. (9802375)	Sabroe R.A.... Greaves M.W.	1998	IGHE
39	Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. (8828024)	Kalis B.	1996	HRH1
40	Effects of systemic corticosteroids on cutaneous histamine secretion and histamine-releasing factor in patients with chronic idiopathic urticaria. (8842556)	Paradis L.... Hebert J.	1996	TPT1
41	Polymorphism of IgE gene in chronic urticaria. (8934659)	Pan K.Y.... Warlow R.S.	1996	IGHE
42	Dermal and bronchial hyperreactivity in urticarial dermographism and urticaria factitia. (8781671)	Henz B.M.... Kunkel G.	1996	IGHE
43	Comparison of histamine-releasing factor recovered from skin and peripheral blood mononuclear cells of patients with chronic idiopathic urticaria. (8970437)	Claveau J.... Hebert J.	1996	TPT1
44	Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)	Longley B.J.... Modlin I.	1996	KIT
45	Behavior of esterase inhibitor C1 in patients with urticaria due to aspirin hypersensitivity (8401339)	Grzelewska-Rzymowska I.... Ruta U.	1993	C1S
46	Heterozygous alpha 1-antichymotrypsin deficiency may be associated with cold urticaria. (1485647)	Lindmark B.... Wallengren J.	1992	SERPINC1, CMA1, SERPINF2
47	Urticaria and angioedema: diagnosis and evaluation. (1869691)	Cooper K.D.	1991	C1S
48	Recurrent urticaria and reduced diamine oxidase activity. (2115815)	Lessof M.H.... Dowling R.H.	1990	ABP1
49	Effectiveness of combination treatment with H1-(Tave gyl) and H2-antagonists (Altramet) in chronic/chronically-recurrent urticaria (2083605)	Wozel G.... Barth J.	1990	HRH1
50	Dermo-distortive urticaria: an autosomal dominant dermatologic disorder. (7294069)	Epstein P.A.... Kidd K.K.	1981	DDU

Genes related to urticaria according to GeneCards:

(show top 50)    (show all 129)

id	Symbol	Description	Score	GeneCards Section Context
1	CPN1	carboxypeptidase N, polypeptide 1	11.0	Summaries
2	DDU	dermo-distortive urticaria	11.0	Publications, Aliases & Descriptions
3	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
4	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
5	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
6	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
7	HRH1	histamine receptor H1	11.0	Publications
8	LTC4S	leukotriene C4 synthase	11.0	Publications
9	KITLG	KIT ligand	11.0	Publications
10	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	11.0	Publications
11	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
12	ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	11.0	Publications
13	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
14	TPO	thyroid peroxidase	11.0	Publications
15	TG	thyroglobulin	11.0	Publications
16	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
17	IL13	interleukin 13	11.0	Publications
18	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
19	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
20	INPPL1	inositol polyphosphate phosphatase-like 1	11.0	Publications
21	TCAP	titin-cap (telethonin)	11.0
22	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
23	HNMT	histamine N-methyltransferase	11.0	Publications
24	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
25	C1S	complement component 1, s subcomponent	11.0	Publications
26	CMA1	chymase 1, mast cell	11.0	Expressions, Publications
27	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	11.0	Publications
28	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
29	POLK	polymerase (DNA directed) kappa	11.0
30	HRH2	histamine receptor H2	11.0	Publications
31	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
32	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
33	GPX1	glutathione peroxidase 1	11.0	Publications
34	IL2RB	interleukin 2 receptor, beta	11.0	Publications
35	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
36	TAT	tyrosine aminotransferase	11.0
37	SYK	spleen tyrosine kinase	11.0	Publications
38	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0
39	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
40	TJP1	tight junction protein 1	11.0
41	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
42	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0
43	SELE	selectin E	11.0	Publications
44	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
45	CHRM3	cholinergic receptor, muscarinic 3	11.0	Publications
46	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0
47	CSN1S1	casein alpha s1	11.0	Publications
48	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
49	KNG1	kininogen 1	11.0	Publications
50	MAP2	microtubule-associated protein 2	11.0

Pathways related to urticaria according to GeneDecks:

(show top 50)    (show all 111)

id	Pathway	Score	Top Affiliating Genes
1	Lymphocyte Signaling3	10.7	GPX1, IL2RA, INPPL1, KIT, KITLG, INPP5D
2	RAR-Gamma-RXR-Alpha Degradation36	10.5	CCL3, CCL11, PF4, IL3
3	NFAT Signaling and Lymphocyte Interactions36	10.5	FCER1A, CCL3, CCL11, CCL2, IL4, IL3
4	Immune response_NFAT in immune response41	10.4	HLA-DPB1, FCER1G, FCER1A, MS4A2, IGHE
5	Cell adhesion molecules (CAMs)20	10.4	HLA-DPB1, ITGB2, SELP
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	CCL3, GZMB, IL2RA, TNFRSF1A, IL2RB
7	Graft-versus-host disease20	10.2	HLA-A, HLA-C, HLA-B, HLA-DQA1, HLA-DPB1, IL1A
8	PGC1Alpha Pathway36	10.0	IL13, TNFRSF1A, CCL3, CCL11, IL8, IL4
9	Endothelin-1 Signaling Pathway36	10.0	CASP1, CCL3, IL4, IL3, IL1A, IL18
10	IL-6 Pathway36	9.9	IL3, IL4, CCL11, IL10, IL8, CXCL10
11	Fc epsilon RI signaling pathway20	9.9	TNF, HRAS, INPP5D, FCER1A, IL4, MS4A2
12	Molecular Mechanisms of Cancer36	9.9	IL13, KITLG, ITGB2, IL1R1, IL3, CCL11
13	Regulation of eIF4 and p70S6K36	9.9	IL4, IL18, IL3, CCL11, CCL3, IL1A
14	Immune response NFAT in immune response10	9.8	CD79A, HLA-DQB1, SYK, PLCG2, FCER1A, HLA-DQA1
15	Viral myocarditis20	9.7	ICAM1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
16	Autoimmune thyroid disease20	9.5	TPO, TG, HLA-DRB1, GZMB, IL10, IL4
17	Staphylococcus aureus infection20	9.5	HLA-DPB1, ICAM1, IL10, FPR2, ITGB2, HLA-DQA1
18	Tec Kinases Signaling36	9.5	IL3, IL4, IL8, CCL2, CCL11, PPBP
19	Hematopoietic cell lineage20	9.4	FCER2, KITLG, KIT, IL1R1, IL2RA, IL3
20	Complement and coagulation cascades20	9.3	C1R, C1S, KLKB1, F12, F2, F3
21	Akt Signaling36	9.3	PF4, TNFRSF1A, TNF, CCL3, CCL11, CXCL10
22	ERK Signaling36	9.2	TGFB1, PRG2, KIT, CXCL10, PPBP, HRAS
23	Rho Family GTPases36	9.2	IL1A, TGFB1, PF4, COL17A1, CCL3, CCL2
24	Natural killer cell mediated cytotoxicity20	9.2	ICAM1, HLA-B, HLA-A, TNF, PLCG2, HRAS
25	all-trans-Retinoic Acid Signaling in Brain36	9.1	IL18, IL13, IL10, CCL11, IL1A, IL3
26	Glucocorticoid Receptor Signaling36	9.1	TGFB1, IL2RA, IL2RB, CCL3, IL10, IL13
27	TGF-Beta Pathway36	9.1	IL1R1, CCL3, IL2RB, IL3, IL4, IL8
28	Pertussis20	9.1	ITGB2, IL10, IL1A, IL8, CASP1, TNF
29	MIF Mediated Glucocorticoid Regulation36	9.0	CXCL10, IL10, IL18, IL1A, IL3, IL4
30	MIF Regulation of Innate Immune Cells36	9.0	CXCL10, IL4, CCL2, IL8, CCL11, CCL3
31	PEDF Induced Signaling36	9.0	CCL2, IL3, IL4, IL1A, IL18, IL13
32	Immune System38	9.0	VCAM1, NLRP3, PLCG2, ICAM1, IFNG, IL3
33	Asthma20	9.0	MS4A2, CD40LG, FCER1A, FCER1G, IL10, IL13
34	THC Differentiation Pathway36	9.0	HLA-DRB1, HLA-DQB1, TNF, HLA-DQA1, TNFRSF1A, IL10
35	Cytokine Network36	8.9	IFNG, IFNA2, IL8, IL4, IL3, IL18
36	Allograft rejection20	8.8	CD40LG, GZMB, TNF, HLA-DRB1, HLA-DQB1, IL10
37	STAT3 Pathway36	8.7	IL18, IL4, PF4, TNFRSF1A, TNF, HRAS
38	Type I diabetes mellitus20	8.7	IFNG, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1
39	Influenza A20	8.6	CASP1, CXCL10, NLRP3, TNFRSF1A, TNF, HLA-DRB1
40	Leishmaniasis20	8.6	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, IFNG
41	PAK Pathway36	8.5	IL2RA, IL3, IL4, IL8, CCL2, CCL11
42	MAPK Family Pathway36	8.2	TGFB1, IL10, KITLG, IL13, TNFRSF1A, TNF
43	Malaria20	8.1	ICAM1, IFNG, TGFB1, TNF, CCL2, IL8
44	p38 Signaling36	8.1	CCL3, HRAS, TNF, TNFRSF1A, PPBP, PLCG2
45	Antioxidant Action of Vitamin-C36	8.1	IL13, PLCG2, PPBP, TNFRSF1A, TNF, HRAS
46	Toxoplasmosis20	8.0	TGFB1, TNFRSF1A, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
47	Tuberculosis20	8.0	IFNG, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
48	Rheumatoid arthritis20	8.0	HLA-DRB1, VEGFA, ITGB2, IL18, IL1A, TGFB1
49	JAK-STAT Pathway36	8.0	IL1A, IL1R1, IL2RA, IL2RB, IL3, IL4
50	Cytokine-cytokine receptor interaction20	6.8	IL2RA, IL1R1, IL1A, IL18, IL13, IL10

Compounds related to urticaria according to GeneDecks:

(show top 50)    (show all 516)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.8	KITLG, CCL11, IGHE, PTGS1, RNASE3
2	glucose32	10.6	KIT, GZMB, IFNA2, TJP1, TGM2, TAT
3	pgd232	10.4	KITLG, IL13, CCL11, ALOX5, PTGDR2, PTGS2
4	ltc432	10.3	ITGB2, IL13, IL3, CCL11, ALOX5, ALOX5AP
5	calcitriol32 42 9 18 9	14.3	KITLG, FCER2, IL13, IL2RA, IL3, ALOX5
6	ivig32	10.3	IL1RAPL2, IL3, CRP, DSG3, TG
7	dmso32	9.9	KITLG, SELP, MAP2, F3, ALOX5, ALOX5AP
8	montelukast32 34 9 9	12.9	IL10, IL13, IL2RA, IL4, IL8, CCL11
9	thromboxane a232 18	10.8	SELP, CD63, ALOX5, PTGDR2, PTGS2, PTGS1
10	atp32	9.8	KIT, CHRM3, CD63, ITGB2, GZMB, FCER2
11	n-formylmethionyl-leucylphenylalanine32	9.8	SELP, ITGB2, FPR2, IL1A, IL3, CCL11
12	polyinosinic-polycytidylic acid32	9.6	SELE, VCAM1, IL10, IL18, IL4, IL8
13	gliadin32	9.5	CD79A, CD40LG, IGHE, HLA-DQB1, TPO, TJP1
14	rolipram32 42	10.4	SELE, ITGB2, IL10, IL13, IL4, IL8
15	polysulfone32	9.2	SELP, VCAM1, ITGB2, IL1R1, IL1RAPL2, IL2RA
16	wortmannin32 42	10.1	KITLG, VCAM1, CHRM3, CD63, ITGB2, MMP9
17	calcium32 9 18 9	12.1	KIT, KITLG, SERPINF2, SERPINB1, CMA1, CD63
18	glutamate32	8.8	CD79A, ITGB2, ITIH4, MMP9, GZMB, INS
19	chloroquine32 34 9 9	11.5	KIT, SERPINC1, CD79A, ITIH4, IL10, IL18
20	n acetylcysteine32	8.4	SELE, SELP, SERPINC1, VCAM1, CD79A, MMP9
21	glutamine32	8.4	KIT, SERPINF2, LPL, ITIH4, FCER2, IL13
22	sulfasalazine32 9 9	10.4	SELE, CD79A, CD40LG, IL1A, IL1R1, IL1RAPL2
23	fmlp32	8.4	SELP, VCAM1, ITGB2, FPR2, FCER2, IL13
24	herbimycin a32 42	9.3	KITLG, SELE, VCAM1, CD40LG, ITGB2, MMP9
25	superoxide32 18	9.3	KITLG, SERPINB1, VCAM1, ITGB2, FPR2, GZMB
26	sb 20358032 42	9.1	SELE, VEGFA, VCAM1, ITGB2, MMP9, FCER2
27	arachidonic acid32 9 18 9	11.0	KITLG, SELP, LPL, CD63, IL13, IL1A
28	pdtc32	8.0	SELE, VCAM1, MMP9, FCER2, IL18, IL1A
29	epinephrine32 9 18 9	10.9	KITLG, SELE, SELP, SERPINF2, CD79A, CD63
30	il 1032	7.9	IL10, IL13, IL18, IL1A, IL1R1, IL1RAPL2
31	hydrocortisone32 9 9	9.9	KITLG, INS, FCER2, IL10, IL13, IL1A
32	rantes32	7.9	KITLG, SELE, SELP, VCAM1, CD40LG, CD63
33	theophylline32 9 18 9	10.9	SELP, LPL, CD79A, CD40LG, IL10, IL13
34	cholesterol32 9 18 9	10.9	KITLG, SELE, SELP, SERPINF2, LPL, VCAM1
35	thymidine32 18	8.7	KIT, KITLG, INPP5D, INPPL1, FCER2, IL10
36	gm-csf32	7.7	KITLG, VEGFA, IL10, IL13, IL18, IL1A
37	estrogen32	7.7	SERPINC1, LPL, GZMB, INS, GSTP1, IL18
38	polysaccharide32	7.7	KITLG, SELE, SELP, SERPINC1, SERPINF2, LPL
39	infliximab32 9 9	9.6	SELE, VEGFA, IL10, IL18, IL1R1, IL1RAPL2
40	arginine32	7.4	SERPINC1, SERPINF2, CD79A, CD40LG, ITGB2, ITIH4
41	neopterin32	7.3	CD79A, CD40LG, GZMB, FCER2, IL10, IL18
42	fibrinogen32	7.1	SELE, SELP, SERPINC1, SERPINF2, VCAM1, CD79A
43	genistein32 9 18 9	9.9	KITLG, SELE, SELP, VEGFA, LPL, VCAM1
44	alanine32	6.8	KITLG, SELE, SERPINC1, SERPINF2, SERPING1, VCAM1
45	nitric oxide32 9 18 9	9.7	KIT, KITLG, SELE, SELP, SERPINA4, VCAM1
46	lipid32	6.7	KITLG, SELE, SERPINF2, LPL, VCAM1, CHRM3
47	creatinine32	6.5	KITLG, SELE, SELP, SERPINC1, CD79A, CD40LG
48	retinoic acid32 42 18	8.2	KIT, KITLG, SELP, VCAM1, CD79A, CD40LG
49	simvastatin32 34 42 9 18 9	11.2	KITLG, SELE, SELP, VEGFA, LPL, VCAM1
50	prostacyclin32	6.1	SELE, SELP, SERPINC1, VEGFA, VCAM1, IL10

Cellular components related to urticaria according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
2	ER to Golgi transport vesicle membrane	GO:012507	9.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
3	MHC class II protein complex	GO:042613	9.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
4	platelet alpha granule lumen	GO:031093	9.0	KNG1, TGFB1, PF4, PPBP, VEGFA, SERPING1
5	external side of plasma membrane	GO:009897	8.4	CXCL10, CD40LG, CD79A, MS4A2, VCAM1, SELP
6	integral to plasma membrane	GO:005887	7.7	TNFRSF1A, TNF, TPO, HLA-DRB1, HLA-DQA1, HLA-C
7	cell surface	GO:009986	7.6	TNFRSF1A, TNF, TPO, IL1R1, IL1A, CD63
8	extracellular region	GO:005576	4.8	CCL3, MMP9, ITIH4, CMA1, LPL, VEGFA
9	plasma membrane	GO:005886	4.8	PTGS1, HLA-A, HRH2, HRH1, HRAS, CAT
10	extracellular space	GO:005615	2.9	KNG1, CPN1, TNF, TPT1, TPSAB1, CALCA

Biological processes related to urticaria according to GeneDecks:

(show top 50)    (show all 65)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of mast cell degranulation	GO:043306	10.8	SYK, FCER1G, FCER1A, MS4A2
2	leukotriene biosynthetic process	GO:019370	10.7	SYK, LTC4S, ALOX5AP, ALOX5, FCER1A
3	neutrophil chemotaxis	GO:030593	10.7	C5AR1, SYK, IFNG, CCL3, CCL2, IL8
4	positive regulation of vasoconstriction	GO:045907	10.6	CYSLTR1, TBXA2R, PTGS1, PTGS2, HRH1, ALOX5
5	chemotaxis	GO:006935	10.5	CYSLTR1, PPBP, CXCL10, C5AR1, PTGDR2, HRAS
6	positive regulation of tumor necrosis factor production	GO:032760	10.4	PF4, TNFRSF1A, IFNG, CCL3, IL18, FCER1G
7	regulation of blood pressure	GO:008217	10.3	SOD2, SOD1, ACE, PTGS1, PTGS2, CALCA
8	defense response to bacterium	GO:042742	10.2	PRG2, SYK, RNASE3, PPBP, TNFRSF1A, IFNG
9	cellular response to interleukin-1	GO:071347	10.2	ICAM1, CCL3, CCL2, IL8, MMP9
10	response to ethanol	GO:045471	10.2	SOD1, TNFRSF1A, ICAM1, CCL2, IL4, IL13
11	positive regulation of MHC class II biosynthetic process	GO:045348	10.2	CD40LG, IL10, IL4, IFNG
12	T cell receptor signaling pathway	GO:050852	10.1	PLCG2, PTPN22, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
13	cellular response to lipopolysaccharide	GO:071222	10.1	LTC4S, ICAM1, IFNG, CCL2, IL8, IL10
14	positive regulation of smooth muscle contraction	GO:045987	10.1	TBXA2R, PTGS1, PTGS2, CHRM3
15	blood coagulation, intrinsic pathway	GO:007597	10.1	KNG1, KLKB1, F12, F2, SERPING1
16	regulation of immune response	GO:050776	10.0	CD40LG, ITGB2, IL4, ICAM1, HLA-A, HLA-B
17	fibrinolysis	GO:042730	10.0	KLKB1, F12, F2, SERPING1, SERPINF2
18	response to organic cyclic compound	GO:014070	10.0	TAT, PTGS2, CASP1, ICAM1, IL4, IL1A
19	response to hyperoxia	GO:055093	10.0	CAT, ALOX5, IL18, MMP9
20	interferon-gamma-mediated signaling pathway	GO:060333	9.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
21	leukocyte cell-cell adhesion	GO:007159	9.8	SYK, CALCA, ICAM1, ITGB2, CD40LG, VCAM1
22	response to radiation	GO:009314	9.8	TGFB1, KIT, MMP9, IL18, CCL11, NGF
23	calcium-mediated signaling	GO:019722	9.8	PLCG2, PTGDR2, TNF, CCL3, IL8, SELE
24	B cell differentiation	GO:030183	9.6	PLCG2, IL4, IL10, CD40LG, CD79A, VCAM1
25	positive regulation of cell adhesion	GO:045785	9.5	TGM2, IFNG, CD63, VEGFA, SELP
26	regulation of cell shape	GO:008360	9.5	F2, KIT, VEGFA, ITGB2, CCL2, CCL11
27	leukocyte tethering or rolling	GO:050901	9.5	TNF, VCAM1, SELP, SELE
28	response to glucocorticoid stimulus	GO:051384	9.4	CPN1, TAT, NGF, PTGS2, TNF, HNMT
29	positive regulation of nitric oxide biosynthetic process	GO:045429	9.4	IFNG, ICAM1, HRH1, TNF, PTGS2, INS
30	cell surface receptor signaling pathway	GO:007166	9.4	HRAS, PRL, CXCL10, ADRB2, F2, IFNG
31	response to lipopolysaccharide	GO:032496	9.3	CXCL10, NGF, PLCG2, TBXA2R, PTGS2, TNFRSF1A
32	positive regulation of angiogenesis	GO:045766	9.3	TBXA2R, TNFRSF1A, F3, CCL11, IL1A, MMP9
33	immune response	GO:006955	9.3	C5AR1, IGHE, CCL11, ENPP3, IL8, IL4
34	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	TGFB1, TNF, CCL3, CCL2, IL18
35	cytokine-mediated signaling pathway	GO:019221	9.3	HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNFRSF1A
36	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	SYK, IL3, FCER1A, INS, VEGFA, KITLG
37	proteolysis	GO:006508	9.2	CPN1, PRTN3, ACE, C1R, C1S, KLKB1
38	cell-cell signaling	GO:007267	9.2	CXCL10, CALCA, IFNA2, CCL3, IL3, IL18
39	cellular response to organic cyclic compound	GO:071407	9.1	TGFB1, TNF, CCL3, CCL2, IL18
40	platelet degranulation	GO:002576	9.1	KNG1, SOD1, TGFB1, PF4, PPBP, CD63
41	acute-phase response	GO:006953	9.0	SERPINF2, ITIH4, INS, F2, CRP
42	positive regulation of cytokine secretion	GO:050715	8.9	SYK, TNF, IL1A, IL10, INS
43	MAPK cascade	GO:000165	8.8	TGFB1, TNF, HRAS, CCL3, CCL2, IL18
44	positive regulation of protein kinase B signaling cascade	GO:051897	8.7	TGFB1, TNF, F3, GPX1, CCL3, INS
45	anti-apoptosis	GO:006916	8.6	SOD1, NGF, TNF, TPT1, F3, GPX1
46	response to drug	GO:042493	8.2	PTGS2, TBXA2R, NGF, LTC4S, ABP1, TGFB1
47	platelet activation	GO:030168	8.1	PPBP, PLCG2, PF4, TGFB1, SYK, SOD1
48	response to hypoxia	GO:001666	7.6	TGFB1, CRP, TNFRSF1A, TNF, CASP1, CAT
49	blood coagulation	GO:007596	7.5	HRAS, TBXA2R, PPBP, PLCG2, PF4, KLKB1
50	inflammatory response	GO:006954	6.9	ADORA3, KNG1, CXCL10, IL8, IL1A, IL18

Molecular functions related to urticaria according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	IgE binding	GO:019863	10.6	FCER2, FCER1G, FCER1A, MS4A2
2	chemokine activity	GO:008009	10.4	CXCL10, PF4, PPBP, CCL3, CCL11, CCL2
3	IgE receptor activity	GO:019767	10.4	FCER1G, FCER1A, MS4A2
4	serine-type endopeptidase activity	GO:004252	9.3	PRTN3, C1S, KLKB1, TPSAB1, F12, F2
5	receptor binding	GO:005102	9.3	CXCL10, HLA-B, HLA-A, CALCA, CAT, F2
6	heparin binding	GO:008201	8.9	KNG1, PRG2, ABP1, PF4, CCL2, LPL
7	protease binding	GO:002020	8.5	TNFRSF1A, TNF, F3, IL1R1, INS, SERPINF2
8	growth factor activity	GO:008083	8.0	TGFB1, NGF, PPBP, F2, IL4, IL3
9	cytokine activity	GO:005125	7.9	KITLG, TNF, IFNG, IFNA2, IL4, IL31
10	protein binding	GO:005515	2.8	TNFRSF1A, TJP1, PTPN22, TBXA2R, CRHR1, TNF