MCID: URT039
MIFTS: 61

Urticaria malady

Skin diseases category

Summaries for Urticaria

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66Wikipedia, 34MalaCards
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Wikipedia:66 Urticaria (from the Latin urtica, \"nettle\" from urere, \"to burn\") commonly referred to as hives, is... more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Melanocyte Development and Pigmentation and Leukotriene modifiers pathway, Pharmacodynamics. The drugs diphenhydramine hydrochloride and chlorpheniramine and the compounds 15hpete and 15-hydroperoxyeicosatetraenoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and thyroid, and related mouse phenotypes are cardiovascular system and skeleton.

Aliases & Classifications for Urticaria

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

urticaria 9 11 46 63


External Ids:

Disease Ontology9 DOID:1555
ICD9CM28 708.8
MeSH36 D014581

Related Diseases for Urticaria

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18GeneCards, 19GeneDecks
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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 277)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa31.8KITLG, KIT
2angioedema31.0ALOX5, LTC4S, HNMT, RNASE3, PTGS1
3mastocytosis31.0KITLG, KIT, CMA1
4asthma30.7RNASE3, LTC4S
5systemic mastocytosis30.6KIT, KITLG
6rhinitis30.6RNASE3, PTGS1, CMA1
7dermatitis30.6ITGB2, CMA1, ALOX5, NLRP3
8allergic rhinitis30.6RNASE3, ALOX5
9atopic dermatitis30.3FCER1A, RNASE3
10psoriasis30.3ITGB2, RNASE3, CMA1, ALOX5
11allergic asthma30.2ITGB2, CMA1, RNASE3, ALOX5
12leukemia30.2KITLG, PTGS1, RNASE3, LTC4S, HRH2, KIT
13atopy30.1RNASE3, LTC4S, CMA1
14eosinophilia30.0ALOX5, RNASE3, ITGB2
15melanoma29.9ALOX5, KIT, KITLG, PTGS1, HRH2
16hypereosinophilic syndrome29.9RNASE3, KIT
17mast-cell leukemia29.8KITLG, KIT
18chronic myelomonocytic leukemia29.8KITLG, KIT
19neurofibroma29.8KIT, KITLG
20pneumonia29.8HRH2, PTGS1
21polycythemia vera29.8KIT, KITLG
22gastroesophageal reflux disease29.8PTGS1, HRH2
23arthritis29.8ITGB2, PTGS1, NLRP3, ALOX5, HRH2
24sinusitis29.8ALOX5, RNASE3, LTC4S
25gastrointestinal stromal tumor29.8KITLG, KIT
26conjunctivitis29.8RNASE3, NLRP3
27mast cell neoplasm29.7KITLG, CMA1, KIT, LTC4S
28rheumatoid arthritis29.7ALOX5, ITGB2, RNASE3, PTGS1
29solar urticaria10.9
30cholinergic urticaria10.8
31papular urticaria10.7
32aquagenic urticaria10.6
33cold contact urticaria10.6
34thyroiditis10.5
35allergic urticaria10.4
36schnitzler syndrome10.4
37familial cold autoinflammatory syndrome10.4
38muckle-wells syndrome10.4
39blindness10.3
40hypohidrosis10.3
41cutaneous mastocytosis10.3
42vibratory urticaria10.2
43dermatographia10.2
44hepatitis10.2
45exercise induced anaphylaxis10.2
46familial cold autoinflammatory syndrome 310.2
47autoimmune thyroiditis10.2
48adult-onset still's disease10.2
49chronic cystitis10.1PTGS1
50kimura disease10.1RNASE3

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Symptoms for Urticaria

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Genetic Tests for Urticaria

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Anatomical Context for Urticaria

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34MalaCards
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MalaCards organs/tissues related to Urticaria:

34
Skin, Testes, Thyroid, Bone, T cells, Bone marrow, B cells, Monocytes, Tonsil, Endothelial, Lung, Eye, Prostate, Colon, Small intestine, Smooth muscle, Whole blood, Breast

Animal Models for Urticaria or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Urticaria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0PTGS1, FCER1A, ITGB2, ALOX5, KIT, KITLG
2MP:00053908.0PTGS1, ITGB2, ALOX5, KIT, KITLG, NLRP3
3MP:00053848.0NLRP3, KITLG, KIT, ALOX5, ITGB2, PTGS1
4MP:00053817.9PTGS1, KIT, KITLG, NLRP3, HRH2
5MP:00107717.9PTGS1, ITGB2, KIT, KITLG, NLRP3, LTC4S
6MP:00053977.1PTGS1, FCER1A, CMA1, ITGB2, ALOX5, KIT
7MP:00053767.0PTGS1, FCER1A, ITGB2, ALOX5, KIT, KITLG
8MP:00053876.6LTC4S, PTGS1, FCER1A, CPN1, CMA1, ITGB2

Publications for Urticaria

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Sources:
53PubMed
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Articles related to Urticaria:

(show top 50)    (show all 1396)
idTitleAuthorsYear
1
Successful use of mycophenolate mofetil to treat severe chronic urticaria in a patient intolerant to ciclosporin. (23692555)
2014
2
Acute urticaria. (24262686)
2014
3
Herpesvirus-associated acute urticaria: an age matched case-control study. (24386470)
2013
4
Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. (23711867)
2013
5
Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection. (22924754)
2013
6
Delayed onset urticaria in depressive patients with bupropion prescription: a nationwide population-based study. (24244611)
2013
7
Chronic urticaria in myasthenia gravis patients - More than occasional coexistence? (23972403)
2013
8
The role of autoimmune testing in chronic idiopathic urticaria. (22541405)
2012
9
Occupational allergic contact urticaria to crustacean in a cook. (22533241)
2012
10
Treatment of severe cold contact urticaria with omalizumab: case reports. (23341807)
2012
11
What is your diagnosis? Urticaria multiforme. (22838086)
2012
12
Cold-induced urticaria with a familial transmission: a case report and review of the literature. (22348744)
2012
13
Class action of oral coumarins in the treatment of a patient with chronic spontaneous urticaria and delayed-pressure urticaria. (22439898)
2012
14
Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria. (21985375)
2011
15
Fexofenadine-induced urticaria. (22346270)
2011
16
Cross-cultural adaptation of the Brazilian-Portuguese version of the chronic urticaria quality-of-life questionnaire - CU-Q2oL. (21899558)
2011
17
Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcI/RII+). (21625019)
2011
18
Specific pattern of flea antigen recognition by IgG subclass and IgE during the progression of papular urticaria caused by flea bite. (20227159)
2010
19
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria. (19178400)
2009
20
Occupational contact urticaria caused by cyclic acid anhydrides. (19338590)
2009
21
Influence of penetrative needling of Shendao (GV 11) on the symptom score and serum IgE content in chronic urticaria patients]. (19916293)
2009
22
Generalized brownish macules in infancy. Urticaria pigmentosa. (19873965)
2009
23
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
24
Synergistic effect of broad-spectrum sunscreens and antihistamines in the control of idiopathic solar urticaria. (18559766)
2008
25
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
26
The thyroid and urticaria. (16131915)
2005
27
Fixed solar urticaria induced by UVA and visible light: a report of a case. (15752128)
2005
28
Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients. (16076300)
2005
29
Interleukin-31. A messenger of T-cells inducing urticaria and eczema reactions]. (15635736)
2004
30
Drug-induced urticaria--activity of selected cytokines and acute phase proteins in plasma. (15314956)
2003
31
Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. (12780723)
2003
32
Drug-induced chronic urticarias]. (12843807)
2003
33
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
34
Urticaria pigmentosa: a clinical, hematopathologic, and serologic study of 30 adults. (9495199)
1998
35
Enhanced P-selectin expression in chronic and dermographic urticaria. (9303336)
1997
36
Urticaria pigmentosa mimicking xanthoma disseminatum. (20952937)
1995
37
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)
1994
38
Chronic idiopathic urticaria: possible contribution of histamine-releasing factor to pathogenesis. (7687607)
1993
39
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984
40
Production and inhibition of solar urticaria by visible light exposure. (6512054)
1984
41
Heat urticaria clinically simulating solar urticaria. (6590049)
1984
42
Immunohistochemical localization of somatostatin-like immunoreactivity in skin lesions from patients with urticaria pigmentosa. (6206641)
1984
43
Solar urticaria. (873670)
1977
44
In vivo studies of mediator release in cold urticaria and cholinergic urticaria. (48522)
1975
45
Cholinergic urticaria with systemic presentation. (5470989)
1970
46
Urticaria pigmentosa. Age of onset and prognosis. (13938746)
1962
47
Urticaria pigmentosa, effects of reserpine. (13711436)
1961
48
Urticaria pigmentosa with visceral and skeletal lesions. (13852143)
1959
49
Urticaria pigmentosa associated with bone lesions; a survey and report of eight cases. (12981299)
1952
50
Urticaria pigmentosa. (15433453)
1950

Variations for Urticaria

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Expression for genes affiliated with Urticaria

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

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Sources:
51PathCards, 54QIAGEN, 52PharmGKB, 56Reactome, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology
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Pathways related to Urticaria according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KITLG, KIT
29.8LTC4S, ALOX5
3
Show member pathways
9.5LTC4S, ALOX5, PTGS1
4
Show member pathways
aspirin triggered resolvin E biosynthesis39
9.5LTC4S, ALOX5, PTGS1
59.5ALOX5, KIT, KITLG
6
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.4KITLG, KIT, ITGB2
7
Show member pathways
9.3FCER1A, RNASE3, ITGB2
8
Show member pathways
8.9FCER1A, ITGB2, KIT, KITLG
9
Show member pathways
8.9KITLG, KIT, ITGB2, FCER1A
10
Show member pathways
8.9FCER1A, CMA1, KIT, KITLG
11
Show member pathways
8.3LTC4S, PTGS1, FCER1A, ALOX5, KIT, KITLG

Compounds for genes affiliated with Urticaria

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
115hpete4610.2ALOX5, PTGS1
215-hydroperoxyeicosatetraenoic acid4610.2PTGS1, ALOX5
3licofelone4610.2PTGS1, ALOX5
4Leukotriene A42510.2LTC4S, ALOX5
5phenidone4610.1PTGS1, ALOX5
6balsalazide46 1211.1ALOX5, PTGS1
7diethylcarbamazine46 1211.1ALOX5, PTGS1
8monochloroacetic acid4610.0KITLG, KIT
9zafirlukast46 30 1212.0ALOX5, RNASE3, PTGS1
1015-hydroxyeicosatetraenoic acid469.9PTGS1, ALOX5
11ltd4469.9LTC4S, ALOX5, RNASE3
12zileuton46 62 30 1212.9ALOX5, PTGS1, LTC4S
13anti-histamine469.9ALOX5, RNASE3, KITLG
14meclofenamic acid46 1210.9ALOX5, PTGS1
15budesonide46 52 1211.9KITLG, PTGS1, RNASE3
16txb2469.9PTGS1, RNASE3, ALOX5
17n-formylmethionyl-leucylphenylalanine469.7RNASE3, ITGB2, ALOX5
18lte4469.7PTGS1, RNASE3, ALOX5, LTC4S
19montelukast46 52 30 1212.7ALOX5, LTC4S, PTGS1, RNASE3
20quinacrine46 1210.6PTGS1, ALOX5, HNMT
21diclofenac46 30 52 1212.6PTGS1, ALOX5, HRH2
22theophylline46 30 25 1212.5HRH2, RNASE3, ALOX5
23hydroxyurea46 52 1211.5KITLG, KIT, ALOX5
24celecoxib46 62 30 52 25 1214.5PTGS1, ALOX5, HRH2
25diphenhydramine46 30 3 25 1213.4PTGS1, HNMT, HRH2
26herbimycin a46 6210.4ITGB2, ALOX5, PTGS1, KITLG
27salbutamol46 52 30 25 1213.3HRH2, KITLG, RNASE3, ITGB2
28imidazole469.3HNMT, HRH2, ALOX5
29prostaglandin469.3PTGS1, HRH2, KITLG, ALOX5
30pgd2469.3ALOX5, LTC4S, KITLG, PTGS1, RNASE3
31ltc4469.3ALOX5, LTC4S, ITGB2, RNASE3, PTGS1
32leukotriene b446 62 2511.3ALOX5, RNASE3, PTGS1, ITGB2, LTC4S
33epinephrine46 25 1211.2RNASE3, ALOX5, KITLG, HRH2
34dmso469.2ALOX5, KITLG, LTC4S, ITGB2, PTGS1
35cycloheximide469.1ALOX5, PTGS1, KITLG, ITGB2, KIT
36arachidonic acid46 30 25 1212.1PTGS1, ALOX5, KITLG, LTC4S
37ethanol46 52 25 1212.1HRH2, RNASE3, KITLG, ITGB2
38h2o2469.1ITGB2, RNASE3, KITLG, ALOX5, PTGS1
39paraffin469.0CMA1, PTGS1, KITLG, KIT
40heparin46 30 25 1212.0ITGB2, KITLG, RNASE3, ALOX5, CMA1
41vegf468.9ITGB2, PTGS1, RNASE3, ALOX5, KIT, KITLG
42dexamethasone46 52 30 1211.9RNASE3, PTGS1, ITGB2, ALOX5, KITLG, LTC4S
43pge2468.8HRH2, LTC4S, RNASE3, KITLG, PTGS1, ALOX5
44lactate468.7ITGB2, KITLG, HRH2, PTGS1, RNASE3, KIT
45genistein46 30 62 3 25 1213.7PTGS1, ITGB2, KITLG, ALOX5
46nitric oxide46 25 1210.7KITLG, KIT, ITGB2, PTGS1, RNASE3, HRH2
47serine468.2ITGB2, ALOX5, KIT, KITLG, HRH2, CMA1
48aspirin46 52 30 2511.2HNMT, RNASE3, PTGS1, ALOX5, KITLG, HRH2
49calcium46 52 25 1210.9CMA1, KIT, ITGB2, KITLG, HRH2, LTC4S
50histamine46 30 258.8HRH2, RNASE3, CMA1, LTC4S, ITGB2, HNMT

GO Terms for genes affiliated with Urticaria

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17Gene Ontology
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Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:03523410.0KITLG, KIT
2lipoxin metabolic processGO:200130010.0LTC4S, ALOX5
3lipoxygenase pathwayGO:01937210.0ALOX5, LTC4S
4leukotriene metabolic processGO:0066919.9LTC4S, ALOX5
5embryonic hemopoiesisGO:0351629.9KITLG, KIT
6arachidonic acid metabolic processGO:0193699.7LTC4S, ALOX5, PTGS1
7digestive tract developmentGO:0485659.6HRH2, KIT
8leukotriene biosynthetic processGO:0193709.5LTC4S, ALOX5, FCER1A
9visual learningGO:0085429.4HRH2, KIT
10Fc-epsilon receptor signaling pathwayGO:0380959.3FCER1A, KIT, KITLG
11inflammatory responseGO:0069549.0NLRP3, KIT, ITGB2
12innate immune responseGO:0450878.3FCER1A, ITGB2, KIT, KITLG, NLRP3

Products for genes affiliated with Urticaria

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  • Antibodies
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  • Antibodies

Sources for Urticaria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet