MCID: URT039
MIFTS: 61

Urticaria malady

Summaries for Urticaria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urticaria (from the Latin urtica, nettle,) commonly referred to as hives, is a kind of skin rash notable... more...

MalaCards: Urticaria is related to urticaria pigmentosa and angioedema. An important gene associated with Urticaria is CPN1 (carboxypeptidase N, polypeptide 1), and among its related pathways are Lymphocyte Signaling and Fc epsilon receptor (FCERI) signaling. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds histamine and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and thyroid, and related mouse phenotypes are immune system and cardiovascular system.

Aliases & Classifications for Urticaria

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

urticaria 8 10 44 60


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Disease Ontology8 DOID:1555
ICD9CM27 708.8
MeSH34 D014581

Related Diseases for Urticaria

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17GeneCards, 18GeneDecks
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Diseases related to Urticaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1urticaria pigmentosa31.6KIT, KITLG
2angioedema31.0C1S, HNMT, IGHE, LTC4S, RNASE3, HRH1
3dermatitis30.6NLRP3, ITGB2, IGHE, CMA1, ALOX5
4asthma30.5RNASE3, ALOX5
5rhinitis30.4IGHE, PRG2, RNASE3, HRH1, TPT1, PTGS1
6systemic mastocytosis30.4KITLG, KIT
7allergic rhinitis30.4IGHE, RNASE3, HRH1, ALOX5
8skin disease30.3HRH1, RNASE3, IGHE, ITGB2
9leukemia30.3ITGB2, PRG2, LTC4S, RNASE3, HRH1, KITLG
10atopic dermatitis30.3PRG2, IGHE, RNASE3, HRH1, CMA1, KITLG
11dermatographia30.3IGHE, PRG2
12psoriasis30.3ITGB2, RNASE3, CMA1, ALOX5
13allergic asthma30.2ITGB2, IGHE, RNASE3, HRH1, CMA1, ALOX5
14chronic rhinitis30.2HRH1, RNASE3
15vasculitis30.1PRG2, ITGB2, C1S
16melanoma29.9PRG2, HRH1, KITLG, KIT, PTGS1, ALOX5
17eosinophilia29.9ITGB2, PRG2, IGHE, RNASE3, ALOX5
18mastocytosis29.9IGHE, CMA1, KITLG, KIT
19arthritis29.9NLRP3, ITGB2, PTGS1, ALOX5
20glomerulonephritis29.9ITGB2, ALOX5
21malaria29.9TPT1, HRH1
22gastritis29.9PTGS1
23anisakiasis29.9RNASE3, IGHE
24toxocariasis29.9IGHE, RNASE3
25mast-cell leukemia29.9KIT, KITLG
26rheumatoid arthritis29.6C1S, ITGB2, PRG2, RNASE3, HRH1, PTGS1
27food allergy29.6C1S, IGHE, RNASE3, TPT1
28mast cell neoplasm29.6KIT, KITLG, CMA1, LTC4S
29conjunctivitis29.6NLRP3, IGHE, RNASE3, HRH1
30allergic conjunctivitis29.6IGHE, RNASE3, HRH1
31pneumonia29.6HRH1, PTGS1
32bullous pemphigoid29.6RNASE3, IGHE, PRG2
33polycythemia vera29.6KITLG, KIT
34eosinophilic gastroenteritis29.6IGHE
35churg-strauss syndrome29.6RNASE3
36polycythemia29.6KITLG
37cystic fibrosis29.6RNASE3
38paragonimiasis29.6IGHE
39myeloma29.6ITGB2, IGHE, KITLG
40cholinergic urticaria10.8
41allergic urticaria10.6
42thyroiditis10.5
43cold contact urticaria10.5
44schnitzler syndrome10.4
45familial cold autoinflammatory syndrome10.3
46aquagenic urticaria10.3
47cutaneous mastocytosis10.3
48autoimmune thyroiditis10.3
49hypohidrosis10.3
50muckle-wells syndrome10.3

Graphical network of the top 20 diseases related to Urticaria:



Diseases related to urticaria

Clinical Features for Urticaria

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Genetic Tests for Urticaria

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Anatomical Context for Urticaria

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32MalaCards
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MalaCards organs/tissues related to Urticaria:

32
Skin, Testes, Thyroid, Bone, T cells, Bone marrow, Endothelial, Lung, B cells, Eye, Monocytes, Tonsil, Whole blood, Prostate, Smooth muscle, Small intestine, Colon, Breast

Animal Models for Urticaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urticaria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8PTGS1, KIT, KITLG, CMA1, HRH1, LTC4S
2MP:000538510.7ALOX5, ITGB2, KITLG, LTC4S, KIT, FCER1A
3MP:000539710.6NLRP3, ALOX5, FCER1A, KIT, KITLG, HRH1
4MP:000537610.4PTGS1, NLRP3, ITGB2, IGHE, HRH1, KITLG

Publications for Urticaria

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50PubMed
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Articles related to Urticaria:

(show top 50)    (show all 1417)
idTitleAuthorsYear
1
Molecular Genetic Mechanisms of Chronic Urticaria. (24404388)
2014
2
Idiopathic cold urticaria and anaphylaxis. (24378859)
2014
3
Study design and quality of reporting of randomized controlled trials of chronic idiopathic or autoimmune urticaria: review. (23940632)
2013
4
Anisakis simplex hypersensitivity is associated with chronic urticaria in endemic areas. (23095317)
2013
5
Chronic urticaria and autoimmunity. (24305753)
2013
6
Aetiological factors associated with chronic urticaria in children: a systematic review. (23224228)
2013
7
Comparative study of systemic psoralen and ultraviolet A and narrowband ultraviolet B in treatment of chronic urticaria. (23281692)
2013
8
Autoantibodies in chronic idiopathic urticaria and nonurticarial systemic autoimmune disorders. (23244655)
2013
9
Psychosocial factors and chronic spontaneous urticaria: a systematic review. (23157275)
2013
10
Urticaria caused by ingestion of pasta and bread containing buckwheat flour. (23967763)
2013
11
Different fish-eating habits and cytokine production in chronic urticaria with and without sensitization against the fish-parasite Anisakis simplex. (23435560)
2013
12
Time for more clinical research on non-steroidal anti-inflammatory drug-induced urticaria/angioedema and anaphylaxis. (23278875)
2013
13
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. (22236196)
2012
14
Screening of hepatitis C virus genotypes in urticaria patients in Saudi Arabia. (22788799)
2012
15
Chapter 21: Urticaria and angioedema. (22794694)
2012
16
The search for genetic links in NSAID-induced acute urticaria and the arachidonic acid pathway. (23181784)
2012
17
Characterization of the inflammatory infiltrate and cytokine expression in the skin of horses with recurrent urticaria. (23140316)
2012
18
Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study. (23174868)
2012
19
Over- and underestimated parameters in severe Hymenoptera venom-induced anaphylaxis: cardiovascular medication and absence of urticaria/angioedema. (22554708)
2012
20
Urticaria and angioedema. (21913206)
2011
21
Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety. (22134570)
2011
22
A case of recurrent toxocariasis presenting with urticaria. (20885912)
2010
23
The genetic association of the FPRL1 promoter polymorphism with chronic urticaria in a Korean population. (20642210)
2010
24
Generalized brownish macules in infancy. Urticaria pigmentosa. (19873965)
2009
25
Improvement of recurrent urticaria in a patient with Schnitzler syndrome associated with B-cell lymphoma with combination rituximab and radiotherapy. (19632739)
2009
26
Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population. (19138248)
2008
27
Insect bite-induced hypersensitivity and the SCRATCH principles: a new approach to papular urticaria. (16751615)
2006
28
Drug-induced chronic urticarias]. (12843807)
2003
29
Solar urticaria induced by infrared radiation. (12653719)
2003
30
Localized aquagenic urticaria: efficacy of a barrier cream. (14678215)
2003
31
Severe pruritus in a patient with urticaria pigmentosa treated with topical 5% urea and 3% polidocanol cream. (14522633)
2003
32
Cholinergic urticaria successfully treated with scopolamine butylbromide. (14521709)
2003
33
UVA rush hardening for the treatment of solar urticaria. (10827409)
2000
34
Aquagenic urticaria. (8833171)
1996
35
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)
1996
36
Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria. (18475708)
1996
37
Urticaria pigmentosa and acute lymphoblastic leukaemia. (7562854)
1995
38
A clinical and histological study of urticaria pigmentosa: relationships between mast cell proliferation and the clinical and histological manifestations. (2384637)
1990
39
Cimetidine treatment of recalcitrant acute allergic urticaria. (3777596)
1986
40
Solar urticaria: treatment with PUVA and mediator inhibitors. (7073982)
1982
41
Mastocytosis without urticaria pigmentosa: a frequently unrecognized cause of recurrent syncope. (7182985)
1982
42
Urticaria pigmentosa: clinical picture and response to oral disodium cromoglycate. (6794592)
1981
43
Familial aquagenic urticaria. (38152)
1979
44
Cholinergic urticaria with systemic presentation. (5470989)
1970
45
Urticaria pigmentosa in children. (5920379)
1966
46
Urticaria pigmentosa. Correlation of clinical, histopathological and biochemical findings. (14461147)
1962
47
The remarkable tissue mast cells; with observations on mast cell acid polysaccharides in the cutaneous lesions of urticaria pigmentosa. (13808638)
1959
48
The simultaneous occurrence of urticaria pigmentosa and primary systemic amyloidosis: report of a case with autopsy findings. (13429164)
1957
49
Systemic mast-cell disease with urticaria pigmentosa. (14360778)
1955
50
Urticaria Pigmentosa of the Macular Type in an Infant. (19974945)
1911

Genetic Variations for Urticaria

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Expression for genes affiliated with Urticaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for genes affiliated with Urticaria

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4Cell Signaling Technology, 53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB
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Compounds for genes affiliated with Urticaria

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Urticaria according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.3TPT1, HNMT, ITGB2, PRG2, IGHE, LTC4S
2calcium44 49 11 2414.2C1S, ITGB2, PRG2, LTC4S, RNASE3, HRH1
3aspirin44 49 28 2414.1C1S, HNMT, LTC4S, RNASE3, HRH1, KITLG
4pgd24411.1PRG2, IGHE, LTC4S, RNASE3, KITLG, PTGS1
5dexamethasone44 49 28 1114.1ITGB2, IGHE, LTC4S, RNASE3, HRH1, KITLG
6ltc44411.1ITGB2, PRG2, LTC4S, RNASE3, PTGS1, ALOX5
7nitric oxide44 11 2413.1C1S, ITGB2, PRG2, RNASE3, HRH1, KITLG
8allergens4411.1PRG2, IGHE, RNASE3, HRH1, CMA1, ENPP3
9lactate4411.1ITGB2, IGHE, RNASE3, KITLG, KIT, PTGS1
10heparin44 28 11 2414.1C1S, ITGB2, PRG2, RNASE3, CMA1, ALOX5
11montelukast44 49 28 1114.1IGHE, LTC4S, RNASE3, PTGS1, ALOX5
12anti-histamine4411.1IGHE, RNASE3, HRH1, KITLG, ALOX5
13leukotriene b444 59 2413.0ITGB2, LTC4S, RNASE3, PTGS1, ALOX5
14nedocromil sodium4411.0IGHE, RNASE3, HRH1, ALOX5, TPT1
15indomethacin44 59 28 1114.0ITGB2, PRG2, IGHE, HRH1, PTGS1, ALOX5
16lte44411.0LTC4S, RNASE3, PTGS1, ALOX5
17ltd44411.0LTC4S, RNASE3, HRH1, ALOX5
18azelastine44 1112.0ALOX5, HRH1, RNASE3, IGHE
19budesonide44 49 1113.0IGHE, RNASE3, KITLG, PTGS1
20salbutamol44 49 28 11 2415.0KITLG, RNASE3, IGHE, ITGB2
21txb24411.0C1S, RNASE3, PTGS1, ALOX5
22fmlp4411.0TPT1, ALOX5, RNASE3, PRG2, ITGB2
23diethylcarbamazine44 1112.0ALOX5, PTGS1, IGHE
24arachidonic acid44 28 11 2414.0LTC4S, HRH1, KITLG, PTGS1, ALOX5, TPT1
25vegf4411.0ITGB2, IGHE, RNASE3, KITLG, KIT, PTGS1
26dmso4411.0ITGB2, LTC4S, KITLG, PTGS1, ALOX5
27capsaicin44 2811.9CMA1, HRH1, RNASE3, IGHE
28sodium cromoglycate4410.9IGHE, RNASE3, HRH1
29toluene diisocyanate4410.9HNMT, IGHE, RNASE3
30arginine4410.9C1S, ITGB2, PRG2, IGHE, RNASE3, ALOX5
31cetirizine44 28 11 2413.9IGHE, RNASE3, HRH1
32zafirlukast44 28 1112.9RNASE3, PTGS1, ALOX5
33loratadine44 11 2412.9IGHE, RNASE3, HRH1
34zileuton59 44 28 1113.9LTC4S, PTGS1, ALOX5
35rantes4410.9ITGB2, RNASE3, HRH1, KITLG, TPT1
36ketotifen44 1111.9IGHE, RNASE3, HRH1
37antimycin a4410.9PRG2, RNASE3, ALOX5
38epinephrine44 11 2412.9IGHE, RNASE3, HRH1, KITLG, ALOX5
39diphenhydramine44 28 2 11 2414.8PTGS1, HRH1, HNMT
40pge24410.8LTC4S
41aspartate4410.8ALOX5, HRH1, IGHE, ITGB2
42latex4410.8C1S, IGHE, RNASE3, KITLG
43prednisolone44 28 1112.8ITGB2, IGHE, RNASE3, KITLG
44estrogen4410.7RNASE3
4515-hydroperoxyeicosatetraenoic acid4410.7PTGS1, ALOX5
46actinomycin d4410.6PTGS1, KIT, KITLG, IGHE, PRG2
47mizolastine4410.6HRH1, ALOX5
48licofelone4410.5PTGS1, ALOX5
4915hpete4410.4PTGS1, ALOX5
50quinacrine44 1111.3HNMT, PTGS1, ALOX5

GO Terms for genes affiliated with Urticaria

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16Gene Ontology
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Cellular components related to Urticaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7ENPP3, KITLG, CMA1, RNASE3, IGHE, PRG2

Biological processes related to Urticaria according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.9FCER1A, C1S, NLRP3, ITGB2, IGHE, KITLG
2leukotriene biosynthetic processGO:01937010.7ALOX5, FCER1A, LTC4S
3germ cell programmed cell deathGO:03523410.7KIT, KITLG
4arachidonic acid metabolic processGO:01936910.7LTC4S, PTGS1, ALOX5
5Fc-epsilon receptor signaling pathwayGO:03809510.7FCER1A, KIT, KITLG, IGHE
6lipoxin metabolic processGO:200130010.5ALOX5, LTC4S
7leukotriene metabolic processGO:00669110.5ALOX5, LTC4S
8lipoxygenase pathwayGO:01937210.4LTC4S, ALOX5
9inflammatory responseGO:00695410.3KIT, HRH1, ITGB2, NLRP3

Products for genes affiliated with Urticaria

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Sources for Urticaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet