MCID: URT008
MIFTS: 40

Urticaria Pigmentosa malady

Summaries for Urticaria Pigmentosa

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Urticaria pigmentosa (also known as \"Generalized eruption of cutaneous mastocytosis (childhood type)\"... more...

MalaCards: Urticaria Pigmentosa, also known as up/mpcm, is related to mastocytosis and systemic mastocytosis. An important gene associated with Urticaria Pigmentosa is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Melanocyte Development and Pigmentation. The compounds monochloroacetic acid and ag-1296 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and smooth muscle.

Description from OMIM:47 154800

Aliases & Classifications for Urticaria Pigmentosa

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 47OMIM, 40NCIt, 57SNOMED-CT
See all sources

Aliases & Descriptions:

urticaria pigmentosa 8 45 61
up/mpcm 8


External Ids:

Disease Ontology8 DOID:12309
MeSH35 D014582
SNOMED-CT57 205566001, 78745000
OMIM47 154800
NCIt40 C3433

Related Diseases for Urticaria Pigmentosa

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Urticaria Pigmentosa:



Diseases related to urticaria pigmentosa

Clinical Features for Urticaria Pigmentosa

Sources:
47OMIM
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Clinical features from OMIM:

154800

Drugs & Therapeutics for Urticaria Pigmentosa

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Urticaria Pigmentosa

Drug clinical trials:

Search ClinicalTrials for Urticaria Pigmentosa

Search NIH Clinical Center for Urticaria Pigmentosa

Search CenterWatch for Urticaria Pigmentosa

Genetic Tests for Urticaria Pigmentosa

Anatomical Context for Urticaria Pigmentosa

Sources:
33MalaCards
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MalaCards organs/tissues related to Urticaria Pigmentosa:

33
Skin, Bone marrow, Smooth muscle, Skeletal muscle, Thyroid, Monocytes, B lymphoblasts, B cells

Animal Models for Urticaria Pigmentosa or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Urticaria Pigmentosa

Sources:
51PubMed
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Articles related to Urticaria Pigmentosa:

(show top 50)    (show all 359)
idTitleAuthorsYear
1
Response of urticaria pigmentosa to cladribine in a patient with systemic mastocytosis. (23205635)
2013
2
Urticaria pigmentosa after treatment with TNF antagonists: a case report. (22184778)
2011
3
Generalized brownish macules in infancy. Urticaria pigmentosa. (19873965)
2009
4
The cosmetic treatment of urticaria pigmentosa with Nd:YAG laser at 532 nanometers. (17166203)
2005
5
Urticaria pigmentosa localized on radiation field. (12948928)
2003
6
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
7
Photo quiz: urticaria pigmentosa. (11006849)
2000
8
The treatment of urticaria pigmentosa with the frequency-doubled Q-switch Nd:YAG laser. (11446093)
2000
9
Intrapartum management of a patient with urticaria pigmentosa. (15321190)
1998
10
Urticaria pigmentosa presenting with massive peripheral eosinophilia. (9263309)
1997
11
Urticaria pigmentosa in identical male twins. (7653189)
1995
12
Concordant urticaria pigmentosa in a couple of identical twins. A five-year follow-up. (8651038)
1995
13
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)
1994
14
Edward Nettleship (1845-1913) and the description of urticaria pigmentosa. (8169028)
1994
15
A clinical and histological study of urticaria pigmentosa: relationships between mast cell proliferation and the clinical and histological manifestations. (2384637)
1990
16
Mechanisms for hyperpigmentation in postinflammatory pigmentation, urticaria pigmentosa and sunburn. (2550287)
1989
17
Sudden intraoperative hypotension in a patient with asymptomatic urticaria pigmentosa. (3565799)
1987
18
Anaphylaxis after Hymenoptera stings in three patients with urticaria pigmentosa. (6196389)
1983
19
Papular dermographism: a sign of urticaria pigmentosa. (6642846)
1983
20
Urticaria pigmentosa with spinal osteoporosis. (4268407)
1973
21
Urticaria pigmentosa in three siblings. (5091873)
1971
22
Degranulation and regranulation of human mast cells. An electron microscopic study of the whealing reaction in urticaria pigmentosa. (4185105)
1969
23
Bone changes in urticaria pigmentosa. A report of a case. (5932535)
1966
24
Urticaria pigmentosa associated with thyroid and ovarian goiter. (5940720)
1966
25
A clinical study of an unusual case of asthma associated with urticaria pigmentosa. (5216210)
1966
26
Urticaria Pigmentosa with Disseminated Mastocytosis Controlled with Chlorambucil. (19994448)
1965
27
Urticaria pigmentosa and generalized mastocytosis. Polymyxin Btreatment. (13684657)
1961
28
Urticaria pigmentosa with systemic lesions and otosclerosis. (14415943)
1960
29
Bone lesions of urticaria pigmentosa in childhood. (14415245)
1959
30
The effect of reserpine on urticaria pigmentosa. (13620959)
1959
31
Histamine and related compounds in urticaria pigmentosa: analyses of tissues having mast-cell infiltration. (13542126)
1958
32
Urticaria pigmentosa; solitary lesions occurring in a mother and her daughter. (13486943)
1958
33
Osseous lesions in urticaria pigmentosa. (13388029)
1957
34
Urticaria pigmentosa; mastocytosis; a consideration of various manifestations. (13457435)
1957
35
Urticaria pigmentosa appearing as a solitary nodular lesion. (13137605)
1954
36
Concomitant bone changes in urticaria pigmentosa. (14938658)
1952
37
The mast cells in urticaria pigmentosa. (14874167)
1951
38
A case for diagnosis; urticaria pigmentosa? histiocytoma? (18098690)
1948
39
A case for diagnosis (parapsoriasis with pigmentation; urticaria pigmentosa?). (20341751)
1947
40
URTICARIA pigmentosa]. (21027907)
1946
41
Urticaria Pigmentosa. (19991410)
1938
42
Urticaria Pigmentosa. (19991188)
1937
43
Urticaria Pigmentosa. (19990741)
1936
44
Urticaria Pigmentosa with Telangiectasis occurring in an Elderly Adult. (19989723)
1934
45
Extensive Urticaria Pigmentosa. (19989434)
1933
46
REPORT OF A CASE OF URTICARIA PIGMENTOSA IN A YOUNG ADULT. (18740130)
1926
47
Urticaria Pigmentosa in an Adult. (19984913)
1926
48
Urticaria Pigmentosa. (19980340)
1919
49
Urticaria Pigmentosa. (19973464)
1909
50
Urticaria pigmentosa. (19972870)
1908

Genetic Variations for Urticaria Pigmentosa

Expression for genes affiliated with Urticaria Pigmentosa

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria Pigmentosa

Search GEO for disease gene expression data for Urticaria Pigmentosa.

Pathways for genes affiliated with Urticaria Pigmentosa

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG, 4Cell Signaling Technology
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Pathways related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5KIT, KITLG
29.5KIT, KITLG
39.5KIT, KITLG
49.5KITLG, KIT
5
Hide members
9.0IL2RA, KITLG, KIT
6
Hide members
9.0IL2RA, KITLG, KIT
7
Hide members
9.0IL2RA, KITLG, KIT
8
Hide members
9.0KIT, KITLG, IL2RA
9
Hide members
9.0IL2RA, KITLG, KIT
10
Hide members
9.0KIT, KITLG, IL2RA
11
Hide members
9.0KIT, KITLG, IL2RA
12
Hide members
9.0IL2RA, KITLG, KIT
139.0IL2RA, KITLG, KIT
149.0KIT, KITLG, IL2RA
159.0KIT, KITLG, IL2RA
169.0KIT, KITLG, IL2RA
17
Hide members
9.0KIT, KITLG, IL2RA
18
Hide members
9.0IL2RA, KITLG, KIT
19
Hide members
8.9KIT, KITLG, CMA1

Compounds for genes affiliated with Urticaria Pigmentosa

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid459.9KIT, KITLG
2ag-1296459.8KIT, KITLG
3su5416459.8KITLG, KIT
4toluidine459.8KITLG, KIT
5rhodamine 12345 5010.8KITLG, KIT
62-chlorodeoxyadenosine459.8KIT, IL2RA
7as 10160 4510.7IL2RA, KITLG
8methylcellulose459.7KIT, KITLG
9chloroquine45 2 50 29 1113.6IL2RA, KIT
10hydroxyurea45 50 1111.6KIT, KITLG
11cytarabine45 50 1111.5KIT, KITLG
12vincristine45 50 1111.4IL2RA, KIT
13gp 130459.3IL2RA, KITLG, KIT
14methotrexate45 50 1111.3KIT, KITLG, IL2RA
155fluorouracil459.3IL2RA, KITLG, KIT
16paclitaxel45 50 1111.3KIT, KITLG, IL2RA
17rapamycin459.3IL2RA, KITLG, KIT
18doxorubicin45 50 1111.2KIT, KITLG, IL2RA
19thymidine45 2410.2IL2RA, KITLG, KIT
20testosterone45 60 11 2412.2KIT, KITLG, IL2RA
21steroid459.1KIT, KITLG, IL2RA
22heparin45 29 11 2412.0KITLG, CMA1, IL2RA
23phosphatidylinositol459.0KIT, KITLG, IL2RA
24histamine45 29 2410.7KIT, KITLG, CMA1, IL2RA
25paraffin458.7KIT, KITLG, CMA1, IL2RA
26vegf458.7KIT, KITLG, IL2RA

GO Terms for genes affiliated with Urticaria Pigmentosa

Sources:
16Gene Ontology
See all sources

Biological processes related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:0352349.5KIT, KITLG
2male gonad developmentGO:0085849.5KIT, KITLG
3embryonic hemopoiesisGO:0351629.4KIT, KITLG
4hemopoiesisGO:0300979.2KIT, KITLG

Products for genes affiliated with Urticaria Pigmentosa

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Urticaria Pigmentosa

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet