Urticaria Pigmentosa malady

Wikipedia: Urticaria pigmentosa (also known as \"Generalized eruption of cutaneous mastocytosis (childhood type)\"...⁴⁴ more...

MalaCards: Urticaria Pigmentosa, also known as urticaria pigmentosa (disorder), is related to cutaneous mastocytosis and urticaria. An important gene associated with Urticaria Pigmentosa is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Melanocyte Development and Pigmentation and Development_EPO-induced MAPK pathway. The compounds monochloroacetic acid and ag-1296 have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Descriptions:

urticaria pigmentosa 6 32 43 urticaria pigmentosa (disorder) 6

up/mpcm 6

Diseases related to urticaria pigmentosa by text searches and GeneDecks gene sharing:

(show top 50)    (show all 61)

id	Related Disease	Score	Top Affiliating Genes
1	cutaneous mastocytosis	30.5	KIT, KITLG
2	urticaria	30.3	TCAP, IL2RA, CMA1, KITLG, KIT
3	mastocytosis	29.6	IL2RA, CMA1, KITLG, KIT
4	indolent systemic mastocytosis	29.2	KITLG, KIT
5	mast cell neoplasm	28.3	CMA1, KITLG, KIT
6	aggressive systemic mastocytosis	13.0	KITLG, KIT
7	mast-cell sarcoma	13.0	KIT, KITLG
8	hyperpigmentation of eyelid	12.9	KIT, KITLG
9	piebaldism	12.9	KITLG, KIT
10	mast-cell leukemia	12.9	KIT, KITLG
11	perivascular epithelioid cell tumor	12.9	KITLG, KIT
12	chronic myelomonocytic leukemia	12.9	KITLG, KIT
13	essential thrombocythemia	12.9	KIT, KITLG
14	germinoma	12.9	KITLG, KIT
15	gliosarcoma	12.9	KIT, KITLG
16	dysgerminoma	12.9	KIT, KITLG
17	gamma chain deficiency	12.9	IL2RA, KITLG
18	adenosquamous carcinoma	12.8	KITLG, KIT
19	hypereosinophilic syndrome	12.8	IL2RA, KIT
20	neurofibromatosis	12.8	KIT, KITLG
21	renal oncocytoma	12.8	KITLG, KIT
22	pure red-cell aplasia	12.8	KITLG, IL2RA
23	letterer-siwe disease	12.8	KITLG, KIT
24	myeloproliferative disorder	12.8	KITLG, KIT
25	neurofibroma	12.7	KITLG, KIT
26	myxoma	12.7	KITLG, KIT
27	gastrointestinal system disease	12.7	KIT, IL2RA
28	plasmodium falciparum malaria	12.7	KITLG, IL2RA
29	angiosarcoma	12.6	KIT, KITLG
30	peripheral primitive neuroectodermal tumor	12.6	KIT, KITLG
31	melanoma metastasis	12.5	KITLG, KIT
32	sm-ahnmd	12.4	KIT, KITLG, IL2RA
33	megakaryoblastic leukemia	12.4	KIT, KITLG, IL2RA
34	hematologic cancer	12.4	IL2RA, KITLG, KIT
35	vitiligo	12.4	KIT, KITLG, IL2RA
36	alopecia	12.4	KIT, KITLG, IL2RA
37	soft tissue sarcoma	12.4	IL2RA, KITLG, KIT
38	merkel cell carcinoma	12.4	KIT, KITLG
39	bronchiolitis	12.4	IL2RA, KITLG, KIT
40	cervical carcinoma	12.3	KIT, KITLG, IL2RA
41	fibrosarcoma	12.3	CMA1, KITLG, KIT
42	duodenitis	12.2	KIT, KITLG, CMA1
43	bronchial asthma	12.2	IL2RA, CMA1, KITLG
44	atopy	12.2	KITLG, CMA1, IL2RA
45	rhinitis	12.2	IL2RA, CMA1, KITLG
46	hyperparathyroidism	12.2	IL2RA, CMA1, KITLG
47	leukemia/lymphoma, t-cell	12.1	KITLG, IL2RA
48	atopic dermatitis	12.1	IL2RA, CMA1, KITLG
49	diabetic retinopathy	12.0	KITLG, IL2RA, TCAP
50	nasopharyngitis	12.0	KIT, KITLG, IL2RA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to urticaria pigmentosa:

²²

Articles related to urticaria pigmentosa:

id	Title	Authors	Year	Affiliating Genes
1	CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis. (18162781)	Hollmann T.J.... Hornick J.L.	2008	IL2RA
2	Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. (12688351)	Noack F.... Horny H.P.	2003	KITLG
3	Mast cells with bilobed or multilobed nuclei in a nodular lesion of a patient with urticaria pigmentosa. (12454601)	Hu S.... Hong H.S.	2002	KIT
4	Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. (11505412)	Beghini A.... Larizza L.	2001	KIT
5	Enhanced expression of SCF in the dermis is a prognostic factor for the regression of urticaria pigmentosa. (10586131)	Onuma H.... Morokashi M.	1999	KITLG
6	Lack of c-kit mutation in familial urticaria pigmentosa. (10354021)	Rosbotham J.L.... Carter N.D.	1999	KIT
7	Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. (8589724)	Longley B.J.... Modlin I.	1996	KIT
8	Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)	Schechter N.M.... Rubin H.	1994	CMA1

Genes related to urticaria pigmentosa according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
2	KITLG	KIT ligand	11.0	Publications
3	CMA1	chymase 1, mast cell	11.0	Expressions, Publications
4	TCAP	titin-cap (telethonin)	11.0
5	IL2RA	interleukin 2 receptor, alpha	11.0	Publications

Pathways related to urticaria pigmentosa according to GeneDecks:

(show all 34)

id	Pathway	Score	Top Affiliating Genes
1	Melanocyte Development and Pigmentation36	9.7	KIT, KITLG
2	Development_EPO-induced MAPK pathway41	9.6	KITLG, KIT
3	Development EPO-induced MAPK pathway10	9.5	KITLG, KIT
4	Hematopoietic cell lineage20	9.4	KIT, KITLG, IL2RA
5	Tyrosine Kinases / Adaptors3	9.4	KIT, KITLG, IL2RA
6	Lymphocyte Signaling3	9.4	IL2RA, KITLG, KIT
7	Apoptotic Pathways in Synovial Fibroblasts36	9.4	KIT, KITLG, IL2RA
8	p53 Mediated Apoptosis36	9.4	IL2RA, KITLG, KIT
9	Telomerase Components in Cell Signaling36	9.4	KIT, KITLG, IL2RA
10	Mitochondrial Apoptosis36	9.4	IL2RA, KITLG, KIT
11	DHA Signaling36	9.4	KIT, KITLG, IL2RA
12	ERK5 Signaling36	9.3	IL2RA, KITLG, KIT
13	Cellular Apoptosis Pathway36	9.3	KIT, KITLG, IL2RA
14	PPAR Pathway36	9.3	IL2RA, KITLG, KIT
15	eIF2 Pathway36	9.3	KIT, KITLG, IL2RA
16	Nuclear Receptor Activation by Vitamin-A36	9.3	IL2RA, KITLG, KIT
17	Rac1 Pathway36	9.3	KIT, KITLG, IL2RA
18	Actin-Based Motility by Rho Family GTPases36	9.3	IL2RA, KITLG, KIT
19	p70S6K Signaling36	9.3	KIT, KITLG, IL2RA
20	Activation of PKC through GPCR36	9.3	IL2RA, KITLG, KIT
21	Renin-Angiotensin Pathway36	9.3	KIT, KITLG, IL2RA
22	Cytokine-cytokine receptor interaction20	9.3	IL2RA, KITLG, KIT
23	CREB Pathway36	9.3	KIT, KITLG, IL2RA
24	PTEN Pathway36	9.3	IL2RA, KITLG, KIT
25	PAK Pathway36	9.2	KIT, KITLG, IL2RA
26	JNK Pathway36	9.2	IL2RA, KITLG, KIT
27	JAK-STAT Pathway36	9.2	KIT, KITLG, IL2RA
28	Breast Cancer Regulation by Stathmin136	9.2	IL2RA, KITLG, KIT
29	Phospholipase-C Pathway36	9.2	KIT, KITLG, IL2RA
30	Antioxidant Action of Vitamin-C36	9.1	IL2RA, KITLG, KIT
31	p38 Signaling36	9.1	KIT, KITLG, IL2RA
32	cAMP Pathway36	9.0	KIT, KITLG, IL2RA
33	MAPK Signaling36	8.9	KIT, KITLG, IL2RA
34	Akt Signaling36	8.7	IL2RA, KITLG, KIT

Compounds related to urticaria pigmentosa according to GeneDecks:

(show all 19)

id	Compound	Score	Top Affiliating Genes
1	monochloroacetic acid32	9.8	KIT, KITLG
2	ag-129632	9.8	KIT, KITLG
3	toluidine32	9.8	KITLG, KIT
4	su541632	9.8	KITLG, KIT
5	as 10132	9.7	KITLG, IL2RA
6	rhodamine 12332 34	10.7	KIT, KITLG
7	2-chlorodeoxyadenosine32	9.6	IL2RA, KIT
8	methylcellulose32	9.5	KIT, KITLG
9	chloroquine32 34 9 9	12.5	KIT, IL2RA
10	gp 13032	9.3	IL2RA, KITLG, KIT
11	methotrexate32 34 42 9 9	13.2	KIT, KITLG, IL2RA
12	5fluorouracil32	9.2	IL2RA, KITLG, KIT
13	paclitaxel32 34 9 9	12.2	KIT, KITLG, IL2RA
14	rapamycin32 42	10.1	IL2RA, KITLG, KIT
15	doxorubicin32 34 9 9	12.1	KIT, KITLG, IL2RA
16	thymidine32 18	9.9	IL2RA, KITLG, KIT
17	histamine32 18	9.7	KIT, KITLG, CMA1, IL2RA
18	paraffin32	8.7	IL2RA, CMA1, KITLG, KIT
19	heparin32 9 18 9	11.5	KITLG, CMA1, IL2RA

Biological processes related to urticaria pigmentosa according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	germ cell programmed cell death	GO:035234	9.6	KIT, KITLG
2	embryonic hemopoiesis	GO:035162	9.5	KIT, KITLG
3	male gonad development	GO:008584	9.5	KIT, KITLG
4	ovarian follicle development	GO:001541	9.4	KITLG, KIT
5	hemopoiesis	GO:030097	9.2	KIT, KITLG