MCID: URT008
MIFTS: 32

Urticaria Pigmentosa malady

Blood diseases category

Aliases & Classifications for Urticaria Pigmentosa

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt
See all sources

Aliases & Descriptions for Urticaria Pigmentosa:

Name: Urticaria Pigmentosa 10 47 65 36
 
Up/mpcm 10


Classifications:



External Ids:

Disease Ontology10 DOID:12309
MeSH36 D014582
SNOMED-CT59 78745000, 205566001
NCIt42 C3433

Summaries for Urticaria Pigmentosa

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MalaCards based summary: Urticaria Pigmentosa, also known as up/mpcm, is related to asthma and urticaria. An important gene associated with Urticaria Pigmentosa is KIT (V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog), and among its related pathways are C-MYB transcription factor network and Melanocyte Development and Pigmentation. Affiliated tissues include bone, skin and bone marrow.

Related Diseases for Urticaria Pigmentosa

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Diseases related to Urticaria Pigmentosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1asthma29.7CALCA, IL2RA, KITLG, VIP
2urticaria11.4
3mastocytosis10.9
4systemic mastocytosis10.6
5cutaneous mastocytosis10.6
6mast cell disease10.5
7leukemia10.5
8telangiectasia macularis eruptiva perstans10.5
9maculopapular cutaneous mastocytosis10.4
10typical urticaria pigmentosa10.4
11nodular urticaria pigmentosa10.4
12osteoporosis10.3
13juvenile xanthogranuloma10.3
14plaque-form urticaria pigmentosa10.3
15gastroesophageal reflux10.3
16skin disease10.3
17indolent systemic mastocytosis10.3
18syringoma10.3
19dermatitis10.3
20eosinophilia10.3
21lymphoblastic leukemia10.3
22mast cell neoplasm10.3
23scabies10.3
24partial sensory epilepsy10.2KIT, KITLG
25space motion sickness10.1KIT, KITLG
26neurohypophysis granular cell tumor10.1KIT, KITLG
27medulloepithelioma10.1FIP1L1, KIT
28hypereosinophilic syndrome, idiopathic, resistant to imatinib10.1FIP1L1, KIT
29exencephaly10.1KIT, KITLG
30cortical blindness10.1KIT, KITLG
31renal tubular acidosis10.1KIT, KITLG
32osteogenesis imperfecta - retinopathy - seizures - intellectual disability10.1FIP1L1, KIT
33gastrointestinal stromal tumor10.1
34atopy10.1
35celiac disease10.1
36multiple myeloma10.1
37incontinentia pigmenti10.1
38keloids10.1
39myelofibrosis10.1
40skin conditions10.1
41thrombocytosis10.1
42diffuse cutaneous mastocytosis10.1
43cutaneous solitary mastocytoma10.1
44acromegaly10.1
45otosclerosis10.1
46parapsoriasis10.1
47lichen planus10.1
48mast-cell leukemia10.1
49rickets10.1
50vascular skin disease10.1

Graphical network of the top 20 diseases related to Urticaria Pigmentosa:



Diseases related to urticaria pigmentosa

Symptoms for Urticaria Pigmentosa

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Drugs & Therapeutics for Urticaria Pigmentosa

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin ConditionsTerminatedNCT00129415Phase 1, Phase 2
2Natural History of Urticaria Pigmentosa in ChildrenCompletedNCT00467792
3Cause and Natural Course of Pediatric-Onset MastocytosisCompletedNCT00050193
4Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy IndividualsCompletedNCT00001760
5Mast Cell Connect: A Registry for Patients With MastocytosisRecruitingNCT02620254
6Study of Factors Regulating Mast Cell ProliferationRecruitingNCT00044122

Search NIH Clinical Center for Urticaria Pigmentosa


Cochrane evidence based reviews: Urticaria Pigmentosa

Genetic Tests for Urticaria Pigmentosa

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Anatomical Context for Urticaria Pigmentosa

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MalaCards organs/tissues related to Urticaria Pigmentosa:

33
Bone, Skin, Bone marrow, Monocytes, Testes, Thyroid, Smooth muscle

Animal Models for Urticaria Pigmentosa or affiliated genes

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Publications for Urticaria Pigmentosa

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Articles related to Urticaria Pigmentosa:

(show top 50)    (show all 364)
idTitleAuthorsYear
1
Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa? (25439382)
2014
2
Familial urticaria pigmentosa: report of a family and review of the role of KIT mutations. (22892471)
2013
3
Cutaneous mastocytosis in twins: multiple mastocytomas and urticaria pigmentosa in two pairs of monozygotic twins. (21385209)
2011
4
Generalized brownish macules in infancy. Urticaria pigmentosa. (19873965)
2009
5
Anaphylaxis to insect sting associated with urticaria pigmentosa. (12866320)
2003
6
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
7
An infant with urticaria pigmentosa and rickets. (12027094)
2002
8
Acute lymphoblastic leukemia and urticaria pigmentosa in an infant. (10797364)
2000
9
Lack of c-kit mutation in familial urticaria pigmentosa. (10354021)
1999
10
Urticaria pigmentosa: a clinical, hematopathologic, and serologic study of 30 adults. (9495199)
1998
11
Urticaria pigmentosa (mastocytosis). (9707879)
1998
12
Urticaria pigmentosa presenting with massive peripheral eosinophilia. (9263309)
1997
13
Urticaria pigmentosa mimicking xanthoma disseminatum. (20952937)
1995
14
Urticaria pigmentosa and acute lymphoblastic leukaemia. (7562854)
1995
15
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (8144971)
1994
16
Urticaria pigmentosa in monozygotic twins. (8024286)
1994
17
What is your diagnosis? Urticaria pigmentosa. (2222680)
1990
18
Histamine release from skin mast cells and basophils in patients with urticaria pigmentosa. (1690493)
1990
19
Immunohistochemical localization of somatostatin-like immunoreactivity in skin lesions from patients with urticaria pigmentosa. (6206641)
1984
20
A double-blind cross-over study of the effect of ketotifen in urticaria pigmentosa. (6341102)
1983
21
Urticaria pigmentosa. Case presentation and discussion. (915191)
1977
22
Urticaria pigmentosa. (1010614)
1976
23
Juvenile xanthogranuloma and urticaria pigmentosa. (804295)
1975
24
Solitary mast cell tumor. Progression to disseminated urticaria pigmentosa in a negro infant. (4973469)
1969
25
Mastocytosis (urticaria pigmentosa) of skin, stomach, and gut with malabsorption. (6034728)
1967
26
Histamine release from the skin of patients with cutaneous mast cell disease (urticaria pigmentosa). (4162559)
1966
27
Urticaria pigmentosa. Age of onset and prognosis. (13938746)
1962
28
Urticaria pigmentosa with generalized tissue mastocytosis and blood basophilia. (13794652)
1960
29
Urticaria pigmentosa with visceral and skeletal lesions. (13852143)
1959
30
The remarkable tissue mast cells; with observations on mast cell acid polysaccharides in the cutaneous lesions of urticaria pigmentosa. (13808638)
1959
31
Histamine and related compounds in urticaria pigmentosa: analyses of tissues having mast-cell infiltration. (13542126)
1958
32
Osseous lesions in urticaria pigmentosa. (13388029)
1957
33
Bullous urticaria pigmentosa; summary of literature and report of two cases. (14375388)
1955
34
Urticaria pigmentosa. (13029935)
1953
35
Urticaria pigmentosa associated with bone lesions; a survey and report of eight cases. (12981299)
1952
36
Urticaria pigmentosa. (15433453)
1950
37
Urticaria pigmentosa of 15 years' duration in a woman aged 41. (14770546)
1950
38
Hydroa puerorum? urticaria pigmentosa. (18135864)
1949
39
A case for diagnosis; urticaria pigmentosa? histiocytoma? (18098690)
1948
40
URTICARIA pigmentosa]. (21027907)
1946
41
Urticaria Pigmentosa, Adult Type. (19992934)
1944
42
Urticaria Pigmentosa in an Adult (Telangiectasia Macularis Eruptiva Perstans, Barber and Parkes Weber Type). (19992635)
1943
43
Urticaria Pigmentosa with Unusual Atrophy, in an Adult. (19992636)
1943
44
Urticaria Pigmentosa with Slight Telangiectasia. (19989584)
1933
45
Urticaria Pigmentosa Nodulosa. (19987805)
1930
46
REPORT OF A CASE OF URTICARIA PIGMENTOSA IN A YOUNG ADULT. (18740130)
1926
47
Urticaria Pigmentosa in an Adult. (19982867)
1923
48
Urticaria Pigmentosa. (19980941)
1920
49
Case of Urticaria Pigmentosa. (19980755)
1919
50
Urticaria Pigmentosa of the Macular Type in an Infant. (19974945)
1911

Variations for Urticaria Pigmentosa

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Expression for genes affiliated with Urticaria Pigmentosa

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Search GEO for disease gene expression data for Urticaria Pigmentosa.

Pathways for genes affiliated with Urticaria Pigmentosa

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Pathways related to Urticaria Pigmentosa according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KIT, KITLG
29.6KIT, KITLG
39.6KIT, KITLG
48.8IL2RA, KIT, KITLG
58.8IL2RA, KIT, KITLG
68.8IL2RA, KIT, KITLG

GO Terms for genes affiliated with Urticaria Pigmentosa

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Biological processes related to Urticaria Pigmentosa according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:003516210.3KIT, KITLG
2ectopic germ cell programmed cell deathGO:003523410.2KIT, KITLG
3positive regulation of MAP kinase activityGO:004340610.1KIT, KITLG
4ovarian follicle developmentGO:000154110.1KIT, KITLG
5response to yeastGO:00018789.9CALCA, VIP
6antifungal humoral responseGO:00197329.9CALCA, VIP
7defense response to Gram-negative bacteriumGO:00508299.9CALCA, VIP
8positive regulation of vasodilationGO:00459099.8CALCA, VIP
9antibacterial humoral responseGO:00197319.8CALCA, VIP
10defense response to Gram-positive bacteriumGO:00508309.8CALCA, VIP
11inflammatory responseGO:00069549.2CALCA, IL2RA, KIT
12MAPK cascadeGO:00001659.1IL2RA, KIT, KITLG
13activation of MAPKK activityGO:00001869.1IL2RA, KIT, KITLG
14Ras protein signal transductionGO:00072659.0IL2RA, KIT, KITLG
15insulin receptor signaling pathwayGO:00082869.0IL2RA, KIT, KITLG
16fibroblast growth factor receptor signaling pathwayGO:00085439.0IL2RA, KIT, KITLG
17Fc-epsilon receptor signaling pathwayGO:00380959.0IL2RA, KIT, KITLG
18neurotrophin TRK receptor signaling pathwayGO:00480118.8IL2RA, KIT, KITLG
19vascular endothelial growth factor receptor signaling pathwayGO:00480108.8IL2RA, KIT, KITLG
20epidermal growth factor receptor signaling pathwayGO:00071738.7IL2RA, KIT, KITLG
21innate immune responseGO:00450877.4CALCA, IL2RA, KIT, KITLG, VIP

Sources for Urticaria Pigmentosa

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet