MCID: URT008
MIFTS: 40

Urticaria Pigmentosa malady

Summaries for Urticaria Pigmentosa

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Urticaria pigmentosa (also known as \"Generalized eruption of cutaneous mastocytosis (childhood type)\"... more...

MalaCards: Urticaria Pigmentosa, also known as up/mpcm, is related to systemic mastocytosis and dermatitis. An important gene associated with Urticaria Pigmentosa is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Melanocyte Development and Pigmentation. The compounds monochloroacetic acid and ag-1296 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow.

Description from OMIM:46 154800

Aliases & Classifications for Urticaria Pigmentosa

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 46OMIM, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

urticaria pigmentosa 8 44 60
up/mpcm 8


External Ids:

Disease Ontology8 DOID:12309
MeSH34 D014582
SNOMED-CT56 205566001, 78745000
OMIM46 154800
NCIt39 C3433

Related Diseases for Urticaria Pigmentosa

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Urticaria Pigmentosa:



Diseases related to urticaria pigmentosa

Clinical Features for Urticaria Pigmentosa

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46OMIM
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Clinical features from OMIM:

154800

Drugs & Therapeutics for Urticaria Pigmentosa

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Urticaria Pigmentosa

Drug clinical trials:

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Search NIH Clinical Center for Urticaria Pigmentosa

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Genetic Tests for Urticaria Pigmentosa

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Anatomical Context for Urticaria Pigmentosa

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Sources:
32MalaCards
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MalaCards organs/tissues related to Urticaria Pigmentosa:

32
Skin, Bone, Bone marrow, Testes, Thyroid, Monocytes, Smooth muscle

Animal Models for Urticaria Pigmentosa or affiliated genes

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Publications for Urticaria Pigmentosa

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50PubMed
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Articles related to Urticaria Pigmentosa:

(show top 50)    (show all 359)
idTitleAuthorsYear
1
Urticaria pigmentosa and mastocytosis: the role of immunophenotyping in diagnosis and determining response to treatment. (16822380)
2006
2
Anesthetic management of a labouring parturient with urticaria pigmentosa. (16575037)
2006
3
Intertriginous urticaria pigmentosa. (15604555)
2005
4
Medium- versus high-dose ultraviolet A1 therapy for urticaria pigmentosa: a pilot study. (14512916)
2003
5
Analysis of c-kit exon 11 and exon 17 of urticaria pigmentosa that occurred in monozygotic twin sisters. (10354083)
1999
6
Urticaria pigmentosa (mastocytosis). (9707879)
1998
7
Reactivated urticaria pigmentosa. (9675535)
1998
8
Bullous urticaria pigmentosa. (8934078)
1996
9
Urticaria pigmentosa mimicking xanthoma disseminatum. (20952937)
1995
10
Malignant germ cell tumor and urticaria pigmentosa. (8736606)
1995
11
Urticaria pigmentosa in monozygotic twins. (8024286)
1994
12
Urticaria-pigmentosa-like lesions in acute lymphoblastic leukaemia (2 cases). (8453153)
1993
13
Mastocytosis and atopy: a study of 33 patients with urticaria pigmentosa. (2288395)
1990
14
Adult-onset urticaria pigmentosa and eruptive syringomas. (3403736)
1988
15
Pigmented papules in the axilla. Urticaria pigmentosa (UP) (mastocytosis). (3415289)
1988
16
Urticaria pigmentosa. (3443473)
1986
17
The bone marrow in urticaria pigmentosa and systemic mastocytosis. Cell composition and mast cell density in relation to urinary excretion of tele-methylimidazoleacetic acid. (3954410)
1986
18
Urticaria pigmentosa responsive to nifedipine. (6491000)
1984
19
Hypercalcitoninaemia in a patient with urticaria pigmentosa. A possible cause of diarrhoea. (6731041)
1984
20
A double-blind cross-over study of the effect of ketotifen in urticaria pigmentosa. (6341102)
1983
21
Blood and urinary heparin and N-acetylneuraminic acid in children with urticaria pigmentosa. (6679689)
1983
22
Urticaria pigmentosa: clinical picture and response to oral disodium cromoglycate. (6794592)
1981
23
Urticaria pigmentosa. (1278950)
1976
24
An immunochemical study on mastocytosis. (Urticaria pigmentosa). (4185106)
1969
25
Genetic aspects of urticaria pigmentosa. (5636045)
1968
26
Urticaria pigmentosa and systemic mastocytosis. (5897781)
1965
27
MASTOCYTOSIS (URTICARIA PIGMENTOSA) WITH URINARY EXCRETION OF HYALURONIC ACID AND CHONDROITIN SULFURIC ACID. CHANGES INDUCED BY POLYMYXIN B. (14117626)
1964
28
HEREDITARY URTICARIA PIGMENTOSA. (14191064)
1964
29
Urticaria pigmentosa, effects of reserpine. (13711436)
1961
30
Further studies of histidine and histamine metabolism in urticaria pigmentosa. (13885343)
1961
31
Urticaria pigmentosa with generalized tissue mastocytosis and blood basophilia. (13794652)
1960
32
Urticaria pigmentosa and allied disorders. (13596517)
1958
33
Urticaria pigmentosa associated with widespread sclerosis of the spongiosa of bone. (13624035)
1958
34
Generalized mast cell disease and urticaria pigmentosa; report of a case. (13441357)
1957
35
Mast cell leukemia presenting as urticaria pigmentosa; report of a case. (13441358)
1957
36
Urticaria pigmentosa associated with bone lesions; a survey and report of eight cases. (12981299)
1952
37
Urticaria Pigmentosa. (19990687)
1936
38
Urticaria Pigmentosa with Slight Telangiectasia. (19989584)
1933
39
Urticaria Pigmentosa in an Adult. (19988297)
1931
40
Urticaria Pigmentosa. (19987799)
1930
41
Urticaria Pigmentosa in an Adult. (19987890)
1930
42
Case of Urticaria Pigmentosa without Mast Cells. (19984279)
1925
43
Case of Urticaria Pigmentosa. (19982868)
1923
44
Case of Urticaria Pigmentosa. (19982870)
1923
45
Case of Urticaria Pigmentosa. (19982900)
1923
46
Case of Urticaria Pigmentosa with Bullous Lesions. (19981607)
1921
47
Case of Urticaria Pigmentosa. (19980755)
1919
48
Case for Diagnosis; (?) Xanthelasmoidea (Urticaria Pigmentosa). (19980767)
1919
49
Generalized Lentiginous Pigmentation in an Adult; (?) Adult Urticaria Pigmentosa. (19977586)
1914
50
Urticaria Pigmentosa in a Baby, aged 10 months. (19975784)
1912

Genetic Variations for Urticaria Pigmentosa

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Expression for genes affiliated with Urticaria Pigmentosa

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urticaria Pigmentosa

Search GEO for disease gene expression data for Urticaria Pigmentosa.

Pathways for genes affiliated with Urticaria Pigmentosa

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37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Pathways related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5KIT, KITLG
29.5KIT, KITLG
39.5KIT, KITLG
49.5KITLG, KIT
5
Hide members
9.0IL2RA, KITLG, KIT
6
Hide members
9.0IL2RA, KITLG, KIT
7
Hide members
9.0IL2RA, KITLG, KIT
8
Hide members
9.0KIT, KITLG, IL2RA
9
Hide members
9.0IL2RA, KITLG, KIT
10
Hide members
9.0KIT, KITLG, IL2RA
11
Hide members
9.0KIT, KITLG, IL2RA
12
Hide members
9.0IL2RA, KITLG, KIT
139.0IL2RA, KITLG, KIT
149.0KIT, KITLG, IL2RA
159.0KIT, KITLG, IL2RA
169.0KIT, KITLG, IL2RA
17
Hide members
9.0KIT, KITLG, IL2RA
18
Hide members
9.0IL2RA, KITLG, KIT
19
Hide members
8.9KIT, KITLG, CMA1

Compounds for genes affiliated with Urticaria Pigmentosa

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid449.9KIT, KITLG
2ag-1296449.8KIT, KITLG
3su5416449.8KITLG, KIT
4toluidine449.8KITLG, KIT
5rhodamine 12344 4910.8KITLG, KIT
62-chlorodeoxyadenosine449.8KIT, IL2RA
7as 10159 4410.7IL2RA, KITLG
8methylcellulose449.7KIT, KITLG
9chloroquine44 2 49 28 1113.6IL2RA, KIT
10hydroxyurea44 49 1111.6KIT, KITLG
11cytarabine44 49 1111.5KIT, KITLG
12vincristine44 49 1111.4IL2RA, KIT
13gp 130449.3IL2RA, KITLG, KIT
14methotrexate44 49 1111.3KIT, KITLG, IL2RA
155fluorouracil449.3IL2RA, KITLG, KIT
16paclitaxel44 49 1111.3KIT, KITLG, IL2RA
17rapamycin449.3IL2RA, KITLG, KIT
18doxorubicin44 49 1111.2KIT, KITLG, IL2RA
19thymidine44 2410.2IL2RA, KITLG, KIT
20testosterone44 59 11 2412.2KIT, KITLG, IL2RA
21steroid449.1KIT, KITLG, IL2RA
22heparin44 28 11 2412.0KITLG, CMA1, IL2RA
23phosphatidylinositol449.0KIT, KITLG, IL2RA
24histamine44 28 2410.7KIT, KITLG, CMA1, IL2RA
25paraffin448.7KIT, KITLG, CMA1, IL2RA
26vegf448.7KIT, KITLG, IL2RA

GO Terms for genes affiliated with Urticaria Pigmentosa

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16Gene Ontology
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Biological processes related to Urticaria Pigmentosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:0352349.5KIT, KITLG
2male gonad developmentGO:0085849.5KIT, KITLG
3embryonic hemopoiesisGO:0351629.4KIT, KITLG
4hemopoiesisGO:0300979.2KIT, KITLG

Products for genes affiliated with Urticaria Pigmentosa

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  • Antibodies
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  • Antibodies

Sources for Urticaria Pigmentosa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet