UIP
MCID: USL001
MIFTS: 38

Usual Interstitial Pneumonia (UIP) malady

Summaries for Usual Interstitial Pneumonia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of... more...

MalaCards: Usual Interstitial Pneumonia, also known as hamman-rich syndrome, is related to pneumonia and idiopathic pulmonary fibrosis. An important gene associated with Usual Interstitial Pneumonia is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and p70S6K Signaling. The compounds cycloheximide and procollagen have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and skeleton.

Aliases & Classifications for Usual Interstitial Pneumonia

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

usual interstitial pneumonia 42
hamman-rich syndrome 60
uip 42


Related Diseases for Usual Interstitial Pneumonia

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17GeneCards, 18GeneDecks
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Diseases related to Usual Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7CCL2, CCL7, SFTPC, SOD3, IL13, IL8
2idiopathic pulmonary fibrosis31.0CCL2, SFTPC, IFNG, TNC, FGF2, CXCL12
3pulmonary fibrosis31.0COL1A1, CCL2, SFTPC, SOD3, TNC, AGTR1
4interstitial lung disease30.8CCL2, SFTPC, IL8, TGFB1
5rheumatoid arthritis30.7CCL2, IFNG, SOD3, CXCR4, CXCL12, IL13
6arthritis30.7CCL2, IFNG, SOD3, AGTR1, FGF2, IL13
7bronchiolitis obliterans30.7IL8
8bronchiolitis30.7IL8, IL13
9lung cancer30.6TGFB1
10sarcoidosis30.6CCL2, IFNG, IL13
11vascular disease30.6CCL2, SOD3, TNC, AGTR1, FGF2
12desquamative interstitial pneumonia30.4TNC
13influenza30.1CXCR4, IFNG
14connective tissue disease30.1TGFB1, CCL2
15ulcerative colitis30.1CCL7, IFNG, IL13, IL8
16nonspecific interstitial pneumonia10.8
17idiopathic interstitial pneumonia10.8
18acute interstitial pneumonia10.4
19bronchiolitis obliterans organizing pneumonia10.4
20collagen disease10.4
21dyskeratosis congenita10.3
22interstitial emphysema10.3
23rheumatoid lung disease10.3
24pulmonary sarcoidosis10.1
25localized pulmonary fibrosis10.1
26asbestosis10.1
27eosinophilic pneumonia10.1
28pneumothorax10.1
29sarcoma10.1
30scleroderma10.1
31pulmonary fibrosis, familial10.1
32meningioma10.0TNC
33keratoconjunctivitis10.0IL13
34esophagitis10.0IL13
35thyroid cancer10.0TNC
36brain glioma10.0CLDN5
37nephrotic syndrome10.0IL13
38neurofibroma10.0TNC
39coronary heart disease10.0AGTR1
40marfan syndrome10.0COL3A1
41hepatitis10.0CXCL12
42liposarcoma10.0TNC
43thrombocytopenia10.0CXCR4
44human immunodeficiency virus infectious disease10.0CXCR4
45hypercholesterolemia10.0AGTR1
46adult t-cell leukemia10.0SERPINH1
47multiple myeloma10.0CXCL12
48moyamoya disease10.0FGF2
49tropical spastic paraparesis10.0SERPINH1
50herpes simplex10.0COL1A1

Graphical network of the top 20 diseases related to Usual Interstitial Pneumonia:



Diseases related to usual interstitial pneumonia

Clinical Features for Usual Interstitial Pneumonia

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Drugs & Therapeutics for Usual Interstitial Pneumonia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Usual Interstitial Pneumonia

Drug clinical trials:

Search ClinicalTrials for Usual Interstitial Pneumonia

Search NIH Clinical Center for Usual Interstitial Pneumonia

Search CenterWatch for Usual Interstitial Pneumonia

Genetic Tests for Usual Interstitial Pneumonia

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Anatomical Context for Usual Interstitial Pneumonia

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32MalaCards
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MalaCards organs/tissues related to Usual Interstitial Pneumonia:

32
Lung

Animal Models for Usual Interstitial Pneumonia or affiliated genes

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36MGI
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Publications for Usual Interstitial Pneumonia

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Genetic Variations for Usual Interstitial Pneumonia

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Expression for genes affiliated with Usual Interstitial Pneumonia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Usual Interstitial Pneumonia

Search GEO for disease gene expression data for Usual Interstitial Pneumonia.

Pathways for genes affiliated with Usual Interstitial Pneumonia

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Sources:
52R&D Systems, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Pathways related to Usual Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL13
2
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10.2AGTR1
39.8IL8, COL3A1
49.7TGFB1, SERPINH1
5
Cell adhesion ECM remodeling
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9.7TNC, COL3A1, COL1A1
6
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9.6CCL2, IL8
79.5TGFB1, CCL2
89.4IL8, IFNG
9
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9.4CCL7, CXCR4, CXCL12, IL13
109.3TNC, FGF2, TGFB1
119.3TGFB1, CXCR4, FGF2
129.3COL1A1, COL3A1, IFNG
13
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9.3FGF2, TNC, COL3A1, COL1A1
14
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9.3COL1A1, COL3A1, TNC, FGF2
159.2SOD3, IFNG, CCL2
16
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9.2CXCL12, CXCR4, AGTR1, COL1A1
179.2TNC, FGF2, CXCR4, CXCL12
189.1IL8, IL13, IFNG
199.1IL8, IL13, IFNG
209.1TGFB1, IL13, IFNG
21
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9.1COL1A1, COL3A1, TNC, FGF2, SERPINH1
22
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9.0IL13, CXCR4, AGTR1, CCL7, CCL2
23
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9.0IFNG, CXCR4, CXCL12, IL13
24
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8.8CCL7, CXCR4, CXCL12, IL13, TGFB1
258.8CCL2, CCL7, CXCR4, CXCL12, IL8
26
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8.8CCL2, CCL7, CXCR4, CXCL12, IL8
27
Development PDGF signaling via STATs and NF-kB
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8.8FGF2, AGTR1, IFNG, CCL2
28
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8.7IL8, IL13, IFNG, CCL2
29
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8.5CCL2, CCL7, AGTR1, CXCR4, CXCL12, IL8
30
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8.4COL1A1, COL3A1, CCL7, TNC, FGF2, CXCR4
31
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7.6CXCL12, CXCR4, FGF2, CCL7, CCL2, IL13
32
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7.1COL1A1, COL3A1, CCL2, CCL7, TNC, CLDN5
33
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6.8COL1A1, COL3A1, CCL2, CCL7, TNC, AKR1B10

Compounds for genes affiliated with Usual Interstitial Pneumonia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Usual Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6CXCL12
2procollagen4410.3TGFB1
3gm-csf44 2811.3IFNG
4matrigel4410.2CXCL12, CXCR4
5pge24410.1TGFB1, COL1A1
6anaphylatoxin449.9IL8, CXCR4, CCL7
7fmlp449.8CXCL12, IL13, CCL7
8sdf 1449.7CCL2, CXCL12, CXCR4
9polysaccharide449.7CCL2, CXCL12, CXCR4
10bleomycin44 1110.7IL13, SFTPC, COL1A1, FGF2
11larc449.6CCL7, CXCR4, CCL2, CXCL12
12mcp 1449.5CXCR4, IL8, CCL7, CCL2
13grobeta449.3CXCL12, CCL2, IL8
14ccl444 2810.3CXCL12, CCL2, CCL7, CXCR4, IL13
15heparin44 28 11 2412.3IL13, CXCL12, CXCR4, IL8, SOD3
16oxygen44 2410.2IL8, SOD3, CCL7, SFTPC, CCL2
17groalpha449.2IL8, CCL7, CXCL12, IL13, CCL2
18heparan sulfate44 2410.2SOD3, CXCL12, CXCR4, FGF2, TNC
19cyclosporin a44 28 5911.2FGF2, CXCR4, IFNG, SERPINH1, COL3A1
20herbimycin a44 5910.2CXCR4, CXCL12, IFNG, IL8
21methacholine44 1110.1AGTR1, IL8, TGFB1, IL13
22il-12449.1IL13, IL8, CCL2, IFNG
23mip 1alpha449.0IL13, IL8, CCL2
24glycosaminoglycan449.0TGFB1, TNC, COL1A1, CXCL12, FGF2
25rantes448.9CXCR4, CCL7, TGFB1, CXCL12, IFNG
26tgf beta1448.7TGFB1, CCL2, TNC, AGTR1, FGF2, IL13
27dexamethasone44 49 28 1111.7FGF2, CXCL12, IL13, TGFB1, SFTPC, CCL7
28cytochalasin d44 599.6CCL2, FGF2, CXCL12, TGFB1, IL8
29hyaluronic acid44 249.6TNC, FGF2, IL13, CXCL12, TGFB1, IL8
30simvastatin44 49 59 28 11 2413.6CCL2, COL1A1, IL8, IFNG, AGTR1
31ribonucleic acid448.6CXCL12, TGFB1, COL3A1, COL1A1, SFTPC, CCL2
32il 10448.6IFNG, IL13, TGFB1, CCL2, IL8
3315-deoxy-delta-12,14-prostaglandin j2448.5FGF2, IFNG, IL8, CCL2
34pdtc448.5IL8, TGFB1, IFNG, CCL2
35serine448.4SOD3, TGFB1, IL13, FGF2, AGTR1, CCL2
36tarc448.3IL13, CXCL12, CCL2, CXCR4, IFNG, CCL7
37ccl344 289.3CXCL12, CXCR4, IFNG, CCL7, IL8, IL13
38pd 98,059448.2CCL2, TGFB1, FGF2, CXCL12, IL13, IL8
39thymidine44 249.1COL3A1, IL13, IFNG, COL1A1, FGF2, TGFB1
40genistein44 28 59 2 11 2413.1FGF2, CCL2, CCL7, IFNG, AGTR1, IL8
41histamine44 28 2410.1TGFB1, CXCR4, IFNG, CCL7, CCL2, IL13
42nitric oxide44 11 2410.0AGTR1, IL13, CXCR4, SOD3, IL8, SERPINH1
43ly294002448.0CXCL12, TGFB1, IL8, CCL2, TNC, IL13
44cysteine448.0COL1A1, TNC, AGTR1, IL8, IFNG, IL13
45arginine447.9IL13, AGTR1, IFNG, SFTPC, CCL2, COL1A1
46oligonucleotide447.8CLDN5, TGFB1, SERPINH1, CXCR4, COL1A1, CCL7
47retinoic acid44 248.8IFNG, TNC, TGFB1, FGF2, CXCR4, IL13
48sb 20358044 598.3CCL2, IFNG, AGTR1, FGF2, CXCR4, TGFB1
49actinomycin d446.7IL8, TGFB1, IL13, CXCL12, CXCR4, FGF2
50vegf446.1COL1A1, CCL2, SFTPC, SOD3, TNC, AGTR1

GO Terms for genes affiliated with Usual Interstitial Pneumonia

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16Gene Ontology
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Cellular components related to Usual Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.2COL1A1, COL3A1, SOD3, TNC
2external side of plasma membraneGO:0098979.0IL13, CXCL12, CXCR4, IFNG
3extracellular regionGO:0055765.8IFNG, CCL7, CCL2, COL3A1, COL1A1, TNC
4extracellular spaceGO:0056155.8TGFB1, COL1A1, COL3A1, CCL2, CCL7, SFTPC

Biological processes related to Usual Interstitial Pneumonia according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCR4, CXCL12
2collagen biosynthetic processGO:03296410.0SERPINH1, COL3A1, COL1A1
3collagen fibril organizationGO:03019910.0COL1A1, COL3A1, SERPINH1
4cellular response to mechanical stimulusGO:0712609.9IL13, SFTPC, COL1A1
5negative regulation of immune responseGO:0507779.9TGFB1, COL3A1
6neutrophil activationGO:0421199.9IL8, CXCR4
7positive regulation of cellular protein metabolic processGO:0322709.7AGTR1, TGFB1
8calcium-mediated signalingGO:0197229.7IL8, CXCR4, AGTR1
9induction of positive chemotaxisGO:0509309.7IL8, CXCL12
10germ cell migrationGO:0083549.7TGFB1, CXCL12, CXCR4
11negative regulation of blood vessel endothelial cell migrationGO:0435379.5FGF2, TGFB1
12chemotaxisGO:0069359.5CXCL12, FGF2, CCL7, CCL2
13response to hypoxiaGO:0016669.3CCL2, SOD3, CXCR4, TGFB1
14cellular calcium ion homeostasisGO:0068749.3CCL2, CCL7, CXCL12, TGFB1
15neutrophil chemotaxisGO:0305939.3CCL2, IFNG, IL8
16hyaluronan catabolic processGO:0302149.3FGF2, TGFB1
17cellular response to lipopolysaccharideGO:0712229.2IL8, IFNG, CCL2
18endoplasmic reticulum unfolded protein responseGO:0309689.1CCL2, IFNG, IL8
19cellular component movementGO:0069289.1IL8, IL13, IFNG
20G-protein coupled receptor signaling pathwayGO:0071869.0CCL2, AGTR1, CXCR4, CXCL12, IL8
21extracellular matrix organizationGO:0301988.9COL1A1, COL3A1, TNC, FGF2, SERPINH1, TGFB1
22inflammatory responseGO:0069548.7CCL2, CCL7, CXCR4, IL13, IL8, TGFB1
23signal transductionGO:0071658.6CCL2, CCL7, FGF2, CXCL12, IL13, IL8

Molecular functions related to Usual Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:0484079.9COL3A1, COL1A1
2CCR2 chemokine receptor bindingGO:0317279.6CCL7, CCL2
3heparin bindingGO:0082019.2CCL2, CCL7, SOD3, FGF2
4chemokine activityGO:0080099.1IL8, CXCL12, CCL7, CCL2

Products for genes affiliated with Usual Interstitial Pneumonia

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Sources for Usual Interstitial Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet