MCID: UTR032
MIFTS: 31

Uterine Body Mixed Cancer

Categories: Cancer diseases

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 14
Malignant Mixed Tumor, Not Otherwise Specified 69
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4114
NCIt 46 C6311

Summaries for Uterine Body Mixed Cancer

Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and endometrioid ovary carcinoma. An important gene associated with Uterine Body Mixed Cancer is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 29.9 ERBB2 ESR2 KIT PGR TP53
2 endometrioid ovary carcinoma 10.3 ARID1A PPP2R1A
3 endometrium carcinoma in situ 10.3 PGR TP53
4 vestibular gland benign neoplasm 10.3 PGR TP53
5 bartholin's gland adenoma 10.3 PGR TP53
6 female reproductive endometrioid cancer 10.3 PGR TP53
7 breast malignant phyllodes tumor 10.3 PGR TP53
8 olfactory groove meningioma 10.2 PGR TP53
9 sarcomatoid squamous cell skin carcinoma 10.2 KIT TP53
10 bartholin's gland benign neoplasm 10.2 PGR TP53
11 chordoid glioma 10.2 PGR TP53
12 cervical carcinosarcoma 10.2 PGR TP53
13 ovary adenocarcinoma 10.2 ARID1A TP53
14 synchronous bilateral breast carcinoma 10.2 PGR TP53
15 papillary serous adenocarcinoma 10.2 PGR TP53
16 anterior cranial fossa meningioma 10.2 PGR TP53
17 glycogen-rich clear cell breast carcinoma 10.2 PGR TP53
18 small cell neuroendocrine carcinoma 10.2 KIT TP53
19 pleomorphic carcinoma 10.2 KIT TP53
20 uterine corpus serous adenocarcinoma 10.2 ERBB2 TP53
21 glioma susceptibility 1 10.2 ERBB2 TP53
22 necrotizing sialometaplasia 10.2 KIT TP53
23 non-proliferative fibrocystic change of the breast 10.2 ERBB2 TP53
24 cribriform carcinoma 10.2 KIT PGR
25 malignant mixed mullerian tumor 10.2 KIT PGR
26 benign breast phyllodes tumor 10.2 KIT PGR
27 fallopian tube adenocarcinoma 10.2 ERBB2 TP53
28 embryonal sarcoma 10.2 KIT TP53
29 adenoid basal cell carcinoma 10.2 KIT PGR
30 breast angiosarcoma 10.1 KIT PGR
31 pleomorphic adenoma carcinoma 10.1 ERBB2 TP53
32 cystic nephroma 10.1 KIT PGR
33 oral leukoplakia 10.1 ERBB2 TP53
34 perivascular epithelioid cell tumor 10.1 KIT PGR
35 esophagus adenocarcinoma 10.1 ERBB2 TP53
36 papillary hidradenoma 10.1 KIT PGR
37 scirrhous adenocarcinoma 10.1 ERBB2 PGR
38 breast apocrine carcinoma 10.1 ERBB2 PGR
39 glassy cell carcinoma of the cervix 10.1 ERBB2 PGR
40 intracystic papillary adenoma 10.1 ERBB2 PGR
41 progesterone-receptor negative breast cancer 10.1 ERBB2 PGR
42 dermoid cyst 10.1 KIT PGR
43 breast medullary carcinoma 10.1 ERBB2 PGR
44 breast scirrhous carcinoma 10.1 ERBB2 PGR
45 oncocytic breast carcinoma 10.1 ERBB2 PGR
46 apocrine adenocarcinoma 10.1 ERBB2 PGR
47 granulosa cell tumor of the ovary 10.1 ERBB2 TP53
48 breast squamous cell carcinoma 10.1 ERBB2 PGR
49 smooth muscle tumor 10.1 KIT PGR
50 hidradenocarcinoma 10.1 ERBB2 TP53

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.23 ARID1A PGR PPP2R1A
2 Decreased homologous recombination repair frequency GR00236-A-2 9.23 ARID1A PGR PIK3R2 PPP2R1A
3 Decreased homologous recombination repair frequency GR00236-A-3 9.23 PIK3R2

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.08 ESR2 ARID1A KIT ERBB2 PIK3R2 PKP3
2 cardiovascular system MP:0005385 10.07 PGR ESR2 ARID1A KIT ERBB2 TP53
3 homeostasis/metabolism MP:0005376 10.06 PGR ESR2 ARID1A KIT ERBB2 TP53
4 cellular MP:0005384 10.05 ERBB2 ESR2 ARID1A KIT TP53 PGR
5 endocrine/exocrine gland MP:0005379 9.97 ESR2 ARID1A KIT ERBB2 TP53 PGR
6 neoplasm MP:0002006 9.92 ESR2 ARID1A KIT ERBB2 PGR PIK3R2
7 integument MP:0010771 9.91 PGR ESR2 KIT ERBB2 TP53 PKP3
8 muscle MP:0005369 9.91 PGR ESR2 ARID1A KIT ERBB2 PIK3R2
9 limbs/digits/tail MP:0005371 9.8 PGR ESR2 KIT ERBB2 TP53
10 normal MP:0002873 9.76 PGR ESR2 ARID1A KIT ERBB2 PKP3
11 no phenotypic analysis MP:0003012 9.65 ESR2 ARID1A KIT TP53 PGR
12 reproductive system MP:0005389 9.43 ESR2 ARID1A KIT ERBB2 TP53 PGR
13 skeleton MP:0005390 9.1 ESR2 ARID1A KIT ERBB2 TP53 PGR

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 ERBB2 ESR2 KIT PIK3R2 PPP2R1A TP53
2
Show member pathways
13.45 ERBB2 ESR2 KIT PIK3R2 PPP2R1A TP53
3
Show member pathways
13.36 ARID1A ERBB2 KIT PIK3R2 PPP2R1A TP53
4
Show member pathways
13.21 ERBB2 KIT PIK3R2 PPP2R1A TP53
5
Show member pathways
13.17 ERBB2 KIT PIK3R2 PPP2R1A TP53
6
Show member pathways
13.08 ERBB2 KIT PIK3R2 PPP2R1A TP53
7
Show member pathways
13 ERBB2 ESR2 KIT PIK3R2 PPP2R1A
8
Show member pathways
12.79 ERBB2 KIT PIK3R2 PPP2R1A TP53
9
Show member pathways
12.75 KIT PIK3R2 PPP2R1A TP53
10 12.38 ERBB2 ESR2 KIT PIK3R2 TP53
11
Show member pathways
12.29 ERBB2 PIK3R2 TP53
12
Show member pathways
12.26 ERBB2 ESR2 PIK3R2 TP53
13
Show member pathways
12.24 ERBB2 PIK3R2 TP53
14
Show member pathways
12.23 PIK3R2 PPP2R1A TP53
15
Show member pathways
12.19 ERBB2 KIT PIK3R2 PPP2R1A TP53
16
Show member pathways
12.14 PGR PIK3R2 PPP2R1A
17
Show member pathways
12.09 ERBB2 ESR2 PIK3R2
18 12.07 ERBB2 PIK3R2 TP53
19
Show member pathways
11.9 ERBB2 PIK3R2 TP53
20
Show member pathways
11.83 ARID1A ERBB2 ESR2 KIT PGR PIK3R2
21 11.82 PIK3R2 PPP2R1A TP53
22
Show member pathways
11.78 ERBB2 PIK3R2 TP53
23 11.74 PIK3R2 PPP2R1A TP53
24 11.71 ERBB2 PIK3R2 TP53
25 11.44 ERBB2 PIK3R2 TP53
26 11.41 ERBB2 PIK3R2 TP53
27 11.32 ARID1A ERBB2 TP53
28 11.1 ESR2 PGR
29 11.07 ERBB2 KIT PIK3R2 TP53
30 10.91 PIK3R2 TP53

GO Terms for Uterine Body Mixed Cancer

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.88 ARID1A ERBB2 ESR2 PGR PPP2R1A TP53
2 positive regulation of protein kinase B signaling GO:0051897 9.43 ERBB2 KIT PIK3R2
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 ERBB2 PIK3R2
4 negative regulation of cell growth GO:0030308 9.33 ESR2 PPP2R1A TP53
5 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ARID1A ESR2
6 positive regulation of gene expression GO:0010628 9.26 ERBB2 KIT PKP3 TP53
7 phosphatidylinositol phosphorylation GO:0046854 8.8 ERBB2 KIT PIK3R2

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.62 ERBB2 PIK3R2 PPP2R1A TP53
2 enzyme binding GO:0019899 9.56 ESR2 PGR PKP3 TP53
3 nuclear receptor activity GO:0004879 9.4 ESR2 PGR
4 steroid binding GO:0005496 9.37 ESR2 PGR
5 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 ERBB2 KIT
6 protein phosphatase binding GO:0019903 9.13 ERBB2 PIK3R2 TP53
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 KIT PIK3R2

Sources for Uterine Body Mixed Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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