MCID: UTR024
MIFTS: 49

Uterine Carcinosarcoma malady

Cancer diseases category

Summaries for Uterine Carcinosarcoma

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32MalaCards
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MalaCards: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to leiomyosarcoma and sarcoma. An important gene associated with Uterine Carcinosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Adherens junction and GPCR Pathway. The compounds cycloheximide and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include uterus, lung and cervix, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Uterine Carcinosarcoma

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

uterine carcinosarcoma 8 44 60
mixed mullerian sarcoma of uterus 8


External Ids:

Disease Ontology8 DOID:6171
NCIt39 C42700

Related Diseases for Uterine Carcinosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Uterine Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.4KIT, MME, MUC1, MUC16, DES, RB1
2sarcoma30.4KIT, MMP7, MUC1, MKI67, ANGPT2, DES
3endometrial stromal sarcoma30.3ESR2, KIT, MME, DES, VIM
4rhabdomyosarcoma30.3DES, TOP1, RB1, S100A1, VIM
5endometrial carcinoma30.3ESR2, ERBB2, MME, CLDN4, CLDN3, MUC16
6pericardial effusion30.1MUC16
7adenosarcoma30.1MME, DES
8neuroendocrine carcinoma30.1KIT, MMP7, MUC1
9chordoma30.1MUC1, DES, S100A1, VIM
10breast cancer30.1ESR2, ERBB2, PTGS2, CTNNB1
11colorectal cancer30.0ESR2, ERBB2, PTGS2, MMP7, MKI67, ANGPT2
12uterine disease10.2
13cardiac tamponade10.1
14large cell carcinoma10.1
15embryonal rhabdomyosarcoma10.1
16lung large cell carcinoma10.1
17ovarian carcinosarcoma10.1
18ductal carcinoma in situ10.0ERBB2
19esophageal cancer10.0PTGS2
20biliary tract neoplasm10.0ERBB2
21stomach cancer10.0ERBB2
22teratoma10.0KIT
23thyroid cancer10.0ANGPT2
24hemangioma10.0ANGPT2
25hepatitis c10.0MMP7
26germ cell tumors10.0KIT
27li-fraumeni syndrome10.0ERBB2
28cystadenoma10.0MME
29renal oncocytoma10.0S100A1
30liver cirrhosis10.0MMP7
31hemangioblastoma10.0MUC1
32lymphangioleiomyomatosis10.0DES
33papilloma10.0RB1
34sertoli-leydig cell tumor10.0MUC1
35hypertension10.0MME
36diabetic retinopathy10.0ANGPT2
37primary hyperoxaluria10.0PTGS2
38craniopharyngioma10.0CTNNB1
39peritonitis10.0MUC16
40prolactinoma10.0ESR2
41nephroblastoma10.0CTNNB1
42hidradenoma10.0MUC1
43infantile myofibromatosis10.0DES
44hepatitis b10.0TOP1
45keratoacanthoma10.0MKI67
46germ cell cancer10.0ESR2
47carney triad10.0KIT
48benign meningioma10.0MKI67
49gastritis10.0PTGS2, MMP7
50adenomatoid tumor10.0VIM

Graphical network of the top 20 diseases related to Uterine Carcinosarcoma:



Diseases related to uterine carcinosarcoma

Clinical Features for Uterine Carcinosarcoma

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Drugs & Therapeutics for Uterine Carcinosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Uterine Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Uterine Carcinosarcoma

Search NIH Clinical Center for Uterine Carcinosarcoma

Search CenterWatch for Uterine Carcinosarcoma

Genetic Tests for Uterine Carcinosarcoma

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Anatomical Context for Uterine Carcinosarcoma

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32MalaCards
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MalaCards organs/tissues related to Uterine Carcinosarcoma:

32
Uterus, Lung, Cervix, Breast, Testis, Endothelial

Animal Models for Uterine Carcinosarcoma or affiliated genes

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36MGI
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Publications for Uterine Carcinosarcoma

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50PubMed
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Articles related to Uterine Carcinosarcoma:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. (24020131)
2013
2
The reasonable timing of the adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent: suggestion based on progression patterns. (23865003)
2013
3
Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma. (23443531)
2013
4
Treatment outcomes in completely resected stage I to stage IV uterine carcinosarcoma with rhabdomyosarcoma differentiation. (24172099)
2013
5
Wilms' tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma. (23344579)
2013
6
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. (23450572)
2013
7
AKT, EGFR, C-ErbB-2, and C-kit expression in uterine carcinosarcoma. (23896716)
2013
8
Uterine carcinosarcoma with scalp metastasis; a rare presentation. (22214642)
2012
9
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
10
Prognostic value of alternative lengthening of telomeres-associated biomarkers in uterine sarcoma and uterine carcinosarcoma. (22266933)
2012
11
Global dysregulation of the chromosome 14q32 imprinted region in uterine carcinosarcoma. (22969950)
2012
12
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (20668868)
2011
13
Uterine carcinosarcoma. (21743326)
2011
14
Stage III uterine carcinosarcoma: 2009 International Federation of Gynecology and Obstetrics Staging System and Prognostic Determinants. (21720252)
2011
15
Uterine carcinosarcoma with p53-positive intraepithelial component. (22026369)
2011
16
The role of cytoreductive surgery for newly diagnosed advanced-stage uterine carcinosarcoma. (21945551)
2011
17
The influence of adjuvant radiotherapy on patterns of failure and survivals in uterine carcinosarcoma. (22984675)
2011
18
A phase II trial of paclitaxel and carboplatin in women with advanced or recurrent uterine carcinosarcoma. (21436700)
2011
19
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. (21446343)
2011
20
Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma. (19276676)
2009
21
Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma. (19309402)
2009
22
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis. (19111933)
2009
23
Patterns of failure for conservatively managed surgical stage I uterine carcinosarcoma: implications for adjuvant therapy. (19574779)
2009
24
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. (19263060)
2009
25
The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. (18160157)
2008
26
Immunohistochemical analysis of carcinomatous and sarcomatous components in the uterine carcinosarcoma: a case report. (18207653)
2008
27
A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma. (18755503)
2008
28
Uterine carcinosarcoma in a patient with hereditary non-polyposis coli. (18065215)
2008
29
Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer. (17666659)
2007
30
Carcinosarcoma of the uterine cervix initially interpreted as myoma nascens. (17701819)
2007
31
Prognostic features of surgical stage I uterine carcinosarcoma. (18059221)
2007
32
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis. (17291261)
2007
33
Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment? (16445668)
2006
34
Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma. (17690557)
2006
35
Aggressive carcinosarcoma of the uterine cervix associated with high levels of granulocyte colony stimulating factor: case report and laboratory correlates. (16782175)
2006
36
Case of uterine cervical carcinosarcoma. (16176508)
2005
37
Importance of the endometrioid carcinoma subtype and sarcomatous component in uterine carcinosarcoma. (15047252)
2004
38
Localization of the VEGF and angiopoietin genes in uterine carcinosarcoma. (15581949)
2004
39
Histogenesis of carcinosarcoma and establishment of leiomyosarcoma cell line (HTMMT) derived from human uterine carcinosarcoma. (15859158)
2004
40
Uterine carcinosarcoma with complete sarcomatous overgrowth mimicking pure embryonal rhabdomyosarcoma. (12496704)
2003
41
Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. (14611676)
2003
42
Evaluation of the relationship between adenosarcoma and carcinosarcoma and a hypothesis of the histogenesis of uterine sarcomas. (12496702)
2003
43
Effect of angiogenesis inhibitor TNP-470 on the growth, blood flow, and microvessel density in xenografts of human uterine carcinosarcoma in nude mice. (12694659)
2003
44
Clinicopathological analysis of c-kit expression in carcinosarcomas and leiomyosarcomas of the uterine corpus. (14529656)
2003
45
Long-term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case-reports and review of the literature. (10928144)
2000
46
Combined diagnostic imaging of uterine carcinosarcoma: A case report. (11240709)
2000
47
TNP-470 inhibits growth and the production of vascular endothelial growth factor of uterine carcinosarcoma cells in vitro. (10769702)
2000
48
Markers of apoptosis and angiogenesis indicate that carcinomatous components play an important role in the malignant behavior of uterine carcinosarcoma. (11150369)
2000
49
Neovascularization of uterine carcinosarcoma: report of two cases analyzed by color Doppler ultrasonography and microvessel density. (10206221)
1999
50
Trousseau's syndrome with brachiocephalic vein thrombosis in a patient with uterine carcinosarcoma. A case report. (10378829)
1999

Genetic Variations for Uterine Carcinosarcoma

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Expression for genes affiliated with Uterine Carcinosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uterine Carcinosarcoma

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Pathways for genes affiliated with Uterine Carcinosarcoma

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29KEGG, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 55SinoBiological, 12EMD Millipore
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Compounds for genes affiliated with Uterine Carcinosarcoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7MME
2resveratrol44 59 11 2413.3ERBB2
3glycogen44 2411.1MKI67, CTNNB1, KIT
4toluidine4410.0S100A1, DES, KIT, VIM
5irinotecan44 49 1112.0MKI67, TOP1, ERBB2, KIT
6trastuzumab44 49 1111.9ERBB2, KIT, MUC1, ANGPT2, CTNNB1
7mucicarmine449.9MUC1, DES, VIM, S100A1
8glucose449.8MUC1, MUC16, ANGPT2, MMP7
9celecoxib44 59 28 49 11 2414.8CTNNB1, PTGS2, ANGPT2, MKI67, ERBB2
10paclitaxel44 49 1111.7ERBB2, MUC16, RB1, CTNNB1, TOP1
11progestin449.7ERBB2, MUC1, ANGPT2, DES, ESR2, VIM
12crcs449.6CTNNB1, RB1, MUC1, MME
13cytarabine44 49 1111.6VIM, KIT, TOP1, RB1, MME, MUC1
14b 723449.6S100A1, MUC1, VIM, DES, MUC16
15dexamethasone44 49 28 1112.6MUC16, ANGPT2, RB1, CTNNB1, MME, PTGS2
16gefitinib44 49 1111.6KIT, VIM, CTNNB1, TOP1, PTGS2, ERBB2
17mifepristone44 59 28 1112.5CTNNB1, ESR2, PTGS2, MUC1, MKI67
18etoposide44 49 59 1112.5RB1, TOP1, ERBB2, VIM, ESR2
19thymidylate449.5MKI67, RB1, TOP1, VIM, ERBB2, ESR2
20p002449.5MMP7, CTNNB1, RB1, DES, MKI67, KIT
21serine449.5ESR2, MUC16, ERBB2, CLDN4, DES, MKI67
22methotrexate44 49 1111.5ERBB2, KIT, MUC1, MKI67, RB1, VIM
23bromodeoxyuridine449.4MME, MKI67, DES, RB1, CTNNB1, VIM
24agar449.4RB1, ERBB2, CTNNB1, TOP1, VIM, MUC1
25gnrh449.4MKI67, CTNNB1, VIM, MME, ERBB2, ESR2
265fluorouracil449.4CTNNB1, TOP1, MKI67, MUC1, KIT, RB1
27steroid449.3DES, MUC16, MME, ERBB2, MKI67, ANGPT2
28ribonucleic acid449.3MMP7, ANGPT2, MUC1, MME, ESR2, KIT
29oxygen44 2410.3MME, ANGPT2, DES, RB1, MKI67, MUC1
30adriamycin449.3RB1, MUC1, ERBB2, DES, MME, CTNNB1
31matrigel449.3MUC1, MMP7, VIM, CTNNB1, RB1, SNAI2
32estradiol44 11 2411.3MUC16, VIM, MKI67, RB1, ESR2, DES
33formaldehyde44 2410.3VIM, ERBB2, KIT, MUC1, MKI67, TOP1
34hematoxylin449.2S100A1, VIM, MKI67, MUC16, MUC1, KIT
35thymidine44 2410.2RB1, CTNNB1, KIT, MME, MUC1, MKI67
36actinomycin d449.2PTGS2, KIT, MME, MUC1, DES, TOP1
37biotin44 11 2411.1VIM, ERBB2, MUC1, RB1, CTNNB1, S100A1
38lactate449.1ERBB2, KIT, MME, MUC16, MKI67, DES
39vincristine44 49 1111.1VIM, RB1, TOP1, MKI67, KIT
40cisplatin44 49 59 1112.0RB1, TOP1, MKI67, CTNNB1, ERBB2, PTGS2
41nitric oxide44 11 2410.7ANGPT2, S100A1, RB1, DES, ANG, MKI67
42cysteine448.6VIM, S100A1, CTNNB1, RB1, DES, ANGPT2
43h2o2448.6VIM, RB1, ESR2, MME, CTNNB1, DES
44testosterone44 59 11 2411.5MKI67, MUC1, MME, KIT, ERBB2, VIM
45doxorubicin44 49 1110.4MME, MUC16, MKI67, DES, TOP1, RB1
46retinoic acid44 249.4ANGPT2, ESR2, VIM, KIT, MMP7, MME
47paraffin447.9MUC1, MUC16, MKI67, ANGPT2, DES, RB1
48progesterone44 59 28 11 2411.8RB1, DES, MKI67, MUC16, MUC1, CLDN4
49tyrosine447.8KIT, MMP7, SNAI2, MME, CLDN4, MUC1
50vegf447.7MUC1, VIM, CTNNB1, RB1, DES, ANG

GO Terms for genes affiliated with Uterine Carcinosarcoma

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16Gene Ontology
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Cellular components related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.1DES, CTNNB1
2nucleusGO:0056347.8ESR2, S100A1, CTNNB1, RB1, SNAI2, TOP1

Biological processes related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:02301410.1ERBB2, KIT
2negative regulation of chondrocyte differentiationGO:03233110.1SNAI2, CTNNB1
3ovarian follicle developmentGO:00154110.0ESR2, KIT, ANG
4response to drugGO:0424939.4CTNNB1, TOP1, MMP7, PTGS2

Molecular functions related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.2ERBB2, KIT
2protein C-terminus bindingGO:0080229.3ERBB2, MKI67, CTNNB1, VIM
3identical protein bindingGO:0428028.9ERBB2, VIM, S100A1, RB1, DES, CLDN3
4protein bindingGO:0055157.2DES, TOP1, RB1, CTNNB1, S100A1, VIM

Products for genes affiliated with Uterine Carcinosarcoma

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Sources for Uterine Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet