Uterine Carcinosarcoma malady

MalaCards: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to synovial sarcoma and epithelioid sarcoma. An important gene associated with Uterine Carcinosarcoma is ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)), and among its related pathways are Akt Signaling and Signal transduction PTEN pathway. The drugs ifosfamide and doxorubicin hydrochloride and the compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include uterus, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Aliases & Descriptions:

uterine carcinosarcoma 6 32 43 mixed mullerian sarcoma of uterus 6

sarcoma 43

Diseases related to uterine carcinosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 823)

id	Related Disease	Score	Top Affiliating Genes
1	synovial sarcoma	34.6	KIT, VIM, BCL2, MUC1, CDH1, MKI67
2	epithelioid sarcoma	34.1	VIM, MUC1, MUC16
3	kaposi's sarcoma	33.9	KIT, RB1, VIM, VEGFA, BCL2, MKI67
4	endometrial stromal sarcoma	33.2	KIT, VIM, MME, ESR2, DES, PGR
5	peripheral primitive neuroectodermal tumor	32.9	KIT, RB1, VIM, S100A1, DES
6	alveolar soft part sarcoma	32.1	VIM, S100A1, CDH1, TP53, CTNNB1, DES
7	uterine sarcoma	32.0	KIT, CDKN2A, MME, MKI67, ERBB2, PTEN
8	spindle cell sarcoma	31.9	VIM, MUC1, DES
9	li-fraumeni syndrome	30.9	ESR2, ERBB2, PGR
10	sarcoma	30.5	KIT, RB1, VIM, VEGFA, BCL2, MUC1
11	prostate stromal sarcoma	30.4	VIM, MUC1
12	biphasic synovial sarcoma	30.4	VIM, BCL2, MUC1, CDH1
13	meninges sarcoma	30.3	VIM, DES
14	rhabdoid tumors	29.9	VIM, MUC1, DES
15	desmoplastic small round cell tumor	29.8	MUC1, DES
16	malignant peripheral nerve sheath tumor	29.7	KIT, VIM, MUC1, S100A1, CDKN2A
17	neuroectodermal tumors	29.4	KIT, RB1, VIM, BCL2, MUC1, S100A1
18	embryonal sarcoma	29.1	KIT, VIM, MKI67, TP53, DES
19	soft tissue sarcoma	28.9	KIT, RB1, VIM, VEGFA, BCL2, CDKN2A
20	castleman's disease	28.3	VEGFA, TP53, EGFR
21	kidney clear cell sarcoma	28.3	VIM, S100A1, MKI67, TP53, PTEN, EGFR
22	gastrointestinal stromal tumor	28.2	PTGS2, CTNNB1
23	cellular leiomyoma	28.1	DES, PGR
24	inflammatory myofibroblastic tumor	27.9	VIM, S100A1, MKI67, PTGS2, DES
25	primary effusion lymphoma	27.7	VEGFA, BCL2, MUC1, CDKN2A, TP53, PTEN
26	endometrial stromal nodule	27.5	VIM, DES, PGR
27	dermatofibrosarcoma protuberans	27.5	KIT, VIM, MUC1, S100A1, TP53, PTGS2
28	breast cancer	27.4	CDH1, ESR2, ERBB2, PTGS2, CTNNB1, EGFR
29	myxoid chondrosarcoma	27.2	VIM, MUC1, S100A1, CDKN2A
30	dna topoisomerase i	27.1	CDKN2A, MKI67, ERBB2, TP53, EGFR, TOP1
31	dermatofibrosarcoma	27.0	KIT, VIM, MUC1, S100A1, TP53, PTGS2
32	lymphoblastic lymphoma	26.5	VIM, BCL2, CDKN2A, MME, MKI67, TP53
33	myofibroma	26.5	VIM, DES
34	myoma	26.4	DES, PGR
35	pseudosarcomatous fibromatosis	26.3	VIM, CTNNB1, DES
36	pemphigus	26.3	CDH1, TP53, CTNNB1, EGFR
37	malignant fibrous histiocytoma	26.2	RB1, VIM, VEGFA, BCL2, MUC1, S100A1
38	mesenchymal chondrosarcoma	26.1	VIM, MUC1, DES
39	extraskeletal myxoid chondrosarcoma	26.1	VIM, MUC1, S100A1
40	endometrial stromal tumor	26.0	VIM, MME, CTNNB1, DES
41	liposarcoma	26.0	KIT, RB1, VIM, VEGFA, BCL2, MUC1
42	perineurioma	26.0	KIT, VIM, MUC1, DES
43	squamous cell carcinoma	26.0	CDH1, MMP7, MKI67, EGFR, TOP1
44	acute lymphoblastic leukemia	25.9	KIT, RB1, BCL2, CDKN2A, MME, TOP1
45	sarcomatoid mesothelioma	25.9	VIM, MUC1, S100A1, DES
46	hemangiopericytoma	25.8	RB1, VIM, VEGFA, MUC1, S100A1, CDH1
47	pleomorphic adenoma	25.7	VIM, MUC1, S100A1, ERBB2, DES
48	renal cell carcinoma	25.7	KIT, VIM, VEGFA, MUC1, S100A1, CDH1
49	adenosarcoma	25.6	KIT, MME, MKI67, DES, PGR
50	fibrous histiocytoma	25.5	RB1, VIM, VEGFA, BCL2, MUC1, S100A1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate, doxorubicin hydrochloride, ifosfamide, mitoxantrone, mitoxantrone hydrochloride, thiotepa

MalaCards organs/tissues related to uterine carcinosarcoma:

²²

MGI Mouse Phenotypes related to uterine carcinosarcoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	SNAI2
2	craniofacial phenotype	MP:0005382	10.3	KIT, SNAI2
3	hematopoietic system phenotype	MP:0005397	9.6	KIT, BCL2, SNAI2
4	normal phenotype	MP:0002873	9.3	PGR, ESR2, VEGFA
5	reproductive system phenotype	MP:0005389	9.2	PTGS2, ERBB2, ESR2, CDH1, VEGFA
6	embryogenesis phenotype	MP:0005380	8.8	PGR, EGFR, SNAI2, CTNNB1, ERBB2, VIM
7	nervous system phenotype	MP:0003631	8.8	EGFR, SNAI2, PTEN, ESR2, RB1, KIT
8	immune system phenotype	MP:0005387	8.5	EGFR, SNAI2, TP53, MMP7, MME, VIM
9	hearing/vestibular/ear phenotype	MP:0005377	8.4	KIT, RB1, BCL2, ESR2, CTNNB1, EGFR
10	limbs/digits/tail phenotype	MP:0005371	8.4	EGFR, CTNNB1, ERBB2, ESR2, VEGFA, RB1
11	liver/biliary system phenotype	MP:0005370	8.3	KIT, VEGFA, ESR2, TP53, EGFR
12	renal/urinary system phenotype	MP:0005367	8.2	EGFR, CTNNB1, PTEN, ESR2, BCL2, KIT
13	behavior/neurological phenotype	MP:0005386	8.1	PGR, DES, SNAI2, CTNNB1, PTEN, ESR2
14	pigmentation phenotype	MP:0001186	7.5	EGFR, SNAI2, CTNNB1, PTEN, TP53, CDKN2A
15	mortality/aging	MP:0010768	7.4	DES, EGFR, SNAI2, PTEN, TP53, ANGPT2
16	adipose tissue phenotype	MP:0005375	7.2	EGFR, PTGS2, PTEN, TP53, ESR2, BCL2
17	no phenotypic analysis	MP:0003012	7.0	EGFR, CTNNB1, PTGS2, TP53, ESR2, CDH1
18	integument phenotype	MP:0010771	6.8	KIT, RB1, BCL2, MUC1, MME, ANGPT2
19	skeleton phenotype	MP:0005390	6.2	PGR, EGFR, SNAI2, CTNNB1, PTGS2, PTEN
20	vision/eye phenotype	MP:0005391	5.7	TP53, PTEN, PTGS2, CTNNB1, SNAI2, EGFR
21	tumorigenesis	MP:0002006	5.7	TP53, PTEN, PTGS2, CTNNB1, EGFR, PGR
22	growth/size phenotype	MP:0005378	5.5	TP53, PTEN, PTGS2, CTNNB1, SNAI2, EGFR
23	muscle phenotype	MP:0005369	5.4	TP53, PTEN, PTGS2, CTNNB1, EGFR, DES
24	digestive/alimentary phenotype	MP:0005381	5.2	MUC1, CDKN2A, CDH1, MMP7, ANGPT2, ESR2
25	cardiovascular system phenotype	MP:0005385	4.9	ERBB2, TP53, PTEN, PTGS2, CTNNB1, EGFR
26	cellular phenotype	MP:0005384	4.9	TP53, PTEN, PTGS2, CTNNB1, SNAI2, EGFR
27	homeostasis/metabolism phenotype	MP:0005376	4.2	ESR2, ERBB2, TP53, PTEN, PTGS2, CTNNB1

Articles related to uterine carcinosarcoma:

(show all 18)

id	Title	Authors	Year	Affiliating Genes
1	COX-2 expression in uterine carcinosarcoma. (19900134)	Menczer J.... Levy T.	2010	PTGS2
2	Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug. (19389926)	Saegusa M.... Okayasu I.	2009	CDH1, RB1, CTNNB1
3	Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. (19200930)	Huang G.S.... Goldberg G.L.	2009	PGR, ESR2
4	Immunohistochemical analysis of carcinomatous and sarcomatous components in the uterine carcinosarcoma: a case report. (18207653)	Semczuk A.... Korobowicz E.	2008	ERBB2, EGFR, RB1
5	Characterization of a newly established uterine carcinosarcoma cell line featuring the sarcomatous phenotype of the tumor in vitro. (18334012)	Schulten H.J.... FA1zesi L.	2008	KIT, VIM, DES
6	Immunohistochemical study of DNA topoisomerase I, p53, and Ki-67 in uterine carcinosarcomas. (17490723)	Lee S.J.... Lee J.H.	2007	TP53, TOP1, MKI67
7	Uterine carcinosarcoma: immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. (17175012)	Cimbaluk D.... Bitterman P.	2007	ERBB2, KIT
8	Overexpression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas. (17545541)	Santin A.D.... Pecorelli S.	2007	CLDN4, CLDN3
9	Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma. (17935762)	Huang G.S.... Einstein M.H.	2007	MUC16
10	DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. (16810312)	Taylor N.P.... Goodfellow P.J.	2006	TP53
11	Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment? (16445668)	Raspollini M.R.... Taddei G.L.	2006	ERBB2
12	HER-2/neu oncogene in uterine carcinosarcoma on tamoxifen therapy. (15901136)	Raspollini M.R.... Taddei G.L.	2005	ERBB2
13	COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? (15589595)	Raspollini M.R.... Taddei G.L.	2005	ERBB2, KIT, PTGS2
14	Expression of p27 and p53: comparative analysis of uterine carcinosarcoma and endometrial carcinoma. (15086737)	Abargel A.... Menczer J.	2004	TP53
15	Localization of the VEGF and angiopoietin genes in uterine carcinosarcoma. (15581949)	Emoto M.... Smith S.K.	2004	VEGFA, ANGPT2, ANG
16	Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. (14611676)	Sawada M.... Matsubara O.	2003	ERBB2, EGFR, KIT
17	Differential expression of matrix metalloprotease-7 in each component of uterine carcinosarcoma. (11032915)	Tanimoto H.... Ohama K.	2000	MMP7
18	Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. (9311600)	Gorai I.... Minaguchi H.	1997	ERBB2

Genes related to uterine carcinosarcoma according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
2	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
3	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
4	CLDN4	claudin 4	11.0	Publications
5	CLDN3	claudin 3	11.0	Publications
6	ANG	angiogenin, ribonuclease, RNase A family, 5	11.0	Publications
7	SNAI2	snail homolog 2 (Drosophila)	11.0	Publications
8	ANGPT2	angiopoietin 2	11.0	Publications
9	S100A1	S100 calcium binding protein A1	11.0	Publications
10	DES	desmin	11.0	Publications
11	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
12	MUC16	mucin 16, cell surface associated	11.0	Publications
13	RB1	retinoblastoma 1	11.0	Publications
14	VIM	vimentin	11.0	Publications
15	MME	membrane metallo-endopeptidase	11.0	Publications
16	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
17	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
18	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
19	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
20	TOP1	topoisomerase (DNA) I	11.0	Publications
21	PTEN	phosphatase and tensin homolog	11.0	Publications
22	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
23	MUC1	mucin 1, cell surface associated	11.0	Publications
24	PGR	progesterone receptor	11.0	Publications
25	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
26	VEGFA	vascular endothelial growth factor A	11.0	Publications
27	TP53	tumor protein p53	11.0	Publications
28	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to uterine carcinosarcoma according to GeneDecks:

(show all 49)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	10.7	KIT
2	Signal transduction PTEN pathway10	10.5	PTEN
3	Cell adhesion_Endothelial cell contacts by junctional mechanisms41	10.3	VIM, CLDN3
4	Development_EGFR signaling via PIP341	10.3	ERBB2, PTEN
5	Non-small cell lung cancer20	10.3	RB1, CDKN2A, ERBB2
6	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.1	BCL2
7	Cell adhesion Endothelial cell contacts by junctional mechanisms10	10.1	CTNNB1, CLDN3, VIM
8	Endothelin-1 Signaling Pathway36	10.1	KIT, ERBB2, EGFR
9	Development EGFR signaling via PIP310	9.8	ERBB2, PTEN, EGFR
10	MIF Regulation of Innate Immune Cells36	9.7	BCL2, ANGPT2, PTGS2
11	Tyrosine Kinases / Adaptors3	9.7	EGFR, ERBB2, ANGPT2, KIT
12	ERK Signaling36	9.6	KIT, ESR2, ERBB2, EGFR
13	Tight junction20	9.6	CTNNB1, PTEN, CLDN3, CLDN4
14	Sertoli-Sertoli Cell Junction Dynamics36	9.6	CLDN4, CLDN3, CDH1, PTEN, CTNNB1
15	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.6	EGFR, CTNNB1, PTEN, ERBB2
16	Translation Non-genomic (rapid) action of Androgen Receptor10	9.6	ERBB2, PTEN, CTNNB1, EGFR
17	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.5	TP53, CDKN2A, RB1
18	Adherens junction20	9.5	EGFR, SNAI2, CTNNB1, ERBB2, CDH1
19	Thyroid cancer20	9.4	CTNNB1, TP53, CDH1
20	EGF Pathway36	9.2	MUC1, CDH1, ERBB2, CTNNB1, EGFR
21	Transcription P53 signaling pathway10	9.2	TP53, CDKN2A, VEGFA
22	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.2	TP53, ERBB2, BCL2
23	Rho Family GTPases36	9.2	DES, ERBB2, ANGPT2, CDH1, BCL2, VIM
24	G1-S Phase Transition36	9.2	RB1, CDKN2A, TP53
25	JNK Pathway36	9.1	TP53, ANGPT2, BCL2, KIT
26	GSK3 Signaling36	9.1	KIT, CDH1, ERBB2, CTNNB1, EGFR
27	Epithelial Adherens Junctions36	9.1	CDH1, ERBB2, PTEN, CTNNB1, SNAI2, EGFR
28	p53 Signaling36	9.1	BCL2, TP53, PTEN
29	Glioblastoma Multiforme36	9.0	EGFR, PTEN, TP53, RB1
30	ILK Signaling36	9.0	EGFR, SNAI2, CTNNB1, PTGS2, ERBB2, CDH1
31	WNT Signaling36	8.9	CTNNB1, PTGS2, TP53, MMP7, CDH1, VIM
32	Small cell lung cancer20	8.8	PTGS2, PTEN, TP53, BCL2, RB1
33	Hepatitis C20	8.7	EGFR, TP53, CLDN3, CLDN4
34	Glioma20	8.7	EGFR, PTEN, TP53, CDKN2A, RB1
35	Colorectal Cancer Metastasis36	8.6	EGFR, CTNNB1, PTGS2, TP53, MMP7, CDH1
36	Endometrial cancer20	8.5	EGFR, CTNNB1, PTEN, TP53, ERBB2, CDH1
37	Mitochondrial Apoptosis36	8.5	EGFR, TP53, CDKN2A, BCL2, KIT
38	Cellular Apoptosis Pathway36	8.5	EGFR, TP53, CDKN2A, BCL2, KIT
39	p53 Mediated Apoptosis36	8.5	EGFR, PTEN, TP53, BCL2, KIT
40	Estrogen Pathway36	8.5	EGFR, ERBB2, ESR2, BCL2, KIT
41	Focal adhesion20	8.5	EGFR, CTNNB1, PTEN, ERBB2, BCL2, VEGFA
42	Melanoma20	8.4	EGFR, PTEN, TP53, CDH1, CDKN2A, RB1
43	p38 Signaling36	8.3	EGFR, TP53, ERBB2, ANGPT2, BCL2, KIT
44	Transcription_P53 signaling pathway41	8.2	CTNNB1, TP53, CDKN2A, BCL2, VEGFA, RB1
45	Prostate cancer20	8.1	EGFR, CTNNB1, PTEN, TP53, ERBB2, BCL2
46	Bladder cancer20	8.0	EGFR, TP53, ERBB2, CDH1, CDKN2A, VEGFA
47	Pancreatic Adenocarcinoma36	7.9	EGFR, PTGS2, TP53, ERBB2, MMP7, CDKN2A
48	Molecular Mechanisms of Cancer36	7.4	EGFR, CTNNB1, PTEN, TP53, ANGPT2, CDH1
49	Pathways in cancer20	7.2	RB1, EGFR, CTNNB1, PTEN, TP53, ERBB2

Compounds related to uterine carcinosarcoma according to GeneDecks:

(show top 50)    (show all 205)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.6	KIT
2	egcg32	10.6	TOP1
3	h2o232	9.8	ESR2, MUC16, MME, DES
4	ly29400232	9.5	PTGS2, ERBB2, CDH1, VEGFA
5	rapamycin32 42	10.0	KIT, RB1, VIM, VEGFA, EGFR
6	retinoic acid32 42 18	10.7	PGR, ESR2, KIT, RB1, CDKN2A, MME
7	progestin32	8.6	VIM, VEGFA, CDH1, ESR2, EGFR, DES
8	biotin32 9 18 9	11.6	MUC1, MKI67, RB1, VIM, S100A1, CDKN2A
9	agar32	8.5	RB1, VIM, CDKN2A, MUC1, CDH1, ERBB2
10	capecitabine32 34 9 9	11.4	KIT, ERBB2, VEGFA, EGFR, TOP1, PGR
11	formaldehyde32 18	9.3	RB1, MUC1, DES, VIM, KIT, TOP1
12	hematoxylin32	8.3	MUC1, MUC16, S100A1, CDKN2A, CDH1, MKI67
13	erlotinib32 34 9 9	11.3	PTGS2, PTEN, ERBB2, CDH1, VEGFA, EGFR
14	cysteine32	8.2	S100A1, ESR2, CDKN2A, PTEN, MUC1, ANGPT2
15	crcs32	7.9	MME, TP53, CTNNB1, MUC1, RB1, CDH1
16	estrogen32	7.9	CLDN4, S100A1, CDH1, MKI67, ANGPT2, ESR2
17	celecoxib32 42 34 9 18 9	12.9	BCL2, CDH1, ANGPT2, MKI67, VEGFA, ERBB2
18	trastuzumab32 34 9 9	10.8	KIT, VEGFA, MUC1, ANGPT2, ERBB2, PTEN
19	matrigel32	7.8	MMP7, RB1, CTNNB1, SNAI2, MUC1, VIM
20	temozolomide32 9 9	9.7	VIM, VEGFA, CDKN2A, TP53, TOP1, EGFR
21	cytarabine32 34 9 9	10.6	MME, CDKN2A, MUC1, BCL2, VIM, RB1
22	gefitinib32 34 9 9	10.5	ERBB2, PTEN, PTGS2, CTNNB1, EGFR, TOP1
23	irinotecan32 34 9 9	10.3	CDH1, MKI67, ERBB2, TP53, PTGS2, EGFR
24	topotecan32 9 9	9.3	TOP1, VEGFA, BCL2, MUC16, ERBB2, TP53
25	carboplatin32 34 9 9	10.3	TP53, RB1, BCL2, MUC16, VEGFA, ERBB2
26	flavopiridol32 9 9	9.3	KIT, RB1, VEGFA, BCL2, CDKN2A, ERBB2
27	steroid32	7.3	MME, MUC16, RB1, KIT, CDKN2A, MKI67
28	geldanamycin32 9 9	9.2	CTNNB1, CDH1, TP53, EGFR, PGR, VEGFA
29	resveratrol32 9 18 9	10.2	TP53, ERBB2, ESR2, BCL2, VEGFA, PTGS2
30	taxane32	7.1	VEGFA, BCL2, ERBB2, TP53, PTEN, EGFR
31	gemcitabine32 34 9 9	9.9	MUC1, VEGFA, TP53, PTEN, BCL2, ERBB2
32	5-aza-2deoxycytidine32	6.8	VIM, CTNNB1, PGR, PTEN, TP53, ESR2
33	docetaxel32 34 9 9	9.8	TP53, EGFR, TOP1, PGR, ERBB2, CDH1
34	progesterone32 42 9 18 9	10.5	PGR, DES, EGFR, CTNNB1, PTEN, ERBB2
35	adriamycin32	6.5	CTNNB1, TOP1, DES, PGR, TP53, ERBB2
36	genistein32 9 18 9	9.4	PTGS2, CTNNB1, EGFR, PGR, PTEN, ERBB2
37	actinomycin d32	6.4	BCL2, MUC1, CDKN2A, MME, ESR2, TP53
38	thymidylate32	6.3	RB1, VIM, VEGFA, BCL2, CDKN2A, CDH1
39	testosterone32 9 18 9	9.3	PTEN, CTNNB1, EGFR, DES, PGR, VIM
40	dexamethasone32 42 34 9 9	10.2	VIM, VEGFA, CLDN4, BCL2, MUC1, MUC16
41	doxorubicin32 34 9 9	9.1	ESR2, ERBB2, TP53, PTEN, CTNNB1, EGFR
42	tyrosine32	5.9	DES, EGFR, SNAI2, CTNNB1, PTEN, ERBB2
43	vegf32	5.7	KIT, CLDN3, BCL2, MUC1, MUC16, CDH1
44	tamoxifen32 34 9 9	8.6	TP53, VEGFA, MUC1, VIM, BCL2, CDH1
45	cisplatin32 34 9 9	8.5	RB1, VEGFA, BCL2, MUC1, TOP1, MUC16
46	5fluorouracil32	5.3	PTEN, CTNNB1, EGFR, TOP1, PGR, TP53
47	paclitaxel32 34 9 9	8.2	TP53, PTEN, CTNNB1, EGFR, TOP1, PGR
48	cycloheximide32	5.2	KIT, CTNNB1, EGFR, TOP1, PGR, PTGS2
49	serine32	4.8	MUC16, CDKN2A, CDH1, MME, MMP7, MKI67
50	paraffin32	3.8	ESR2, ERBB2, TP53, PTEN, CTNNB1, EGFR

Cellular components related to uterine carcinosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lateral plasma membrane	GO:016328	9.5	CTNNB1, CDH1, CLDN4
2	extracellular space	GO:005615	8.4	KIT, VEGFA, MUC16, MMP7, ANG, ANGPT2
3	nucleus	GO:005634	4.9	KIT, PGR, TOP1, EGFR, SNAI2, CTNNB1
4	cytoplasm	GO:005737	4.9	TP53, PTEN, PTGS2, CTNNB1, SNAI2, EGFR

Biological processes related to uterine carcinosarcoma according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of protein localization to cell surface	GO:2000008	10.1	CDH1, CTNNB1
2	lymphoid progenitor cell differentiation	GO:002320	9.9	KIT, BCL2
3	cellular response to indole-3-methanol	GO:071681	9.9	CDH1, CTNNB1
4	response to radiation	GO:009314	9.9	ANGPT2, BCL2, KIT
5	negative regulation of epithelial cell proliferation	GO:050680	9.7	PTEN, ESR2, RB1
6	cellular component disassembly involved in apoptotic process	GO:006921	9.7	VIM, CDH1, CTNNB1
7	ovarian follicle development	GO:001541	9.6	KIT, BCL2, ANG, ESR2
8	positive regulation of cell migration involved in sprouting angiogenesis	GO:090050	9.6	PTGS2, VEGFA
9	regulation of protein stability	GO:031647	9.6	BCL2, CDKN2A, PTEN
10	rRNA transcription	GO:009303	9.5	CDKN2A, ANG, TP53
11	replicative senescence	GO:090399	9.5	TP53, MME, CDKN2A
12	positive regulation of MAP kinase activity	GO:043406	9.4	VEGFA, ERBB2, EGFR
13	response to cytokine stimulus	GO:034097	9.2	BCL2, PTGS2, CTNNB1
14	B cell lineage commitment	GO:002326	9.2	BCL2, TP53
15	neuron apoptotic process	GO:051402	9.2	RB1, BCL2, TP53
16	cell-cell adhesion	GO:016337	9.1	EGFR, CTNNB1, CDH1, BCL2
17	response to hypoxia	GO:001666	9.1	ANGPT2, ANG, BCL2, CLDN3, VEGFA
18	response to drug	GO:042493	9.0	TOP1, CTNNB1, PTGS2, MMP7, CDH1, BCL2
19	negative regulation of cell growth	GO:030308	8.6	TP53, ESR2, CDKN2A, BCL2, RB1
20	negative regulation of apoptotic process	GO:043066	7.8	EGFR, SNAI2, PTEN, TP53, BCL2, VEGFA

Molecular functions related to uterine carcinosarcoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor signaling protein tyrosine kinase activity	GO:004716	9.8	KIT, ERBB2, EGFR
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.6	EGFR, ERBB2, KIT
3	epidermal growth factor-activated receptor activity	GO:005006	9.5	ERBB2, EGFR
4	transmembrane signaling receptor activity	GO:004888	9.5	CLDN4, CLDN3, ERBB2, EGFR
5	protein phosphatase binding	GO:019903	9.4	EGFR, CTNNB1, ERBB2, CDH1
6	transcription factor binding	GO:008134	8.4	CTNNB1, TP53, CDKN2A, BCL2, RB1
7	identical protein binding	GO:042802	7.9	EGFR, TP53, ERBB2, S100A1, BCL2, CLDN3
8	protein heterodimerization activity	GO:046982	7.8	VEGFA, BCL2, ERBB2, TP53, EGFR
9	enzyme binding	GO:019899	7.7	PGR, EGFR, CTNNB1, PTGS2, PTEN, TP53
10	protein binding	GO:005515	3.3	KIT, ANGPT2, ESR2, ERBB2, TP53, PTEN