MCID: UTR024
MIFTS: 45

Uterine Carcinosarcoma malady

Cancer diseases category
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Summaries for Uterine Carcinosarcoma

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Disease Ontology:8 A uterine body mixed cancer that has material basis in both endometrial carcinoma and sarcoma.

MalaCards based summary: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to breast cancer and endometrial carcinoma. An important gene associated with Uterine Carcinosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Endometrial cancer and C-MYB transcription factor network. The compounds capecitabine and everolimus have been mentioned in the context of this disorder. Affiliated tissues include uterus, lung and breast, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Uterine Carcinosarcoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt
See all sources

Uterine Carcinosarcoma, Aliases & Descriptions:

Name: Uterine Carcinosarcoma 8 44 62
 
Mixed Mullerian Sarcoma of Uterus 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:6171
NCIt39 C42700

Related Diseases for Uterine Carcinosarcoma

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Diseases related to Uterine Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.5ERBB2, PTGS2
2endometrial carcinoma30.3ANGPT2, ANG, ERBB2
3colorectal cancer30.1ERBB2, ANGPT2, PTGS2
4li-fraumeni syndrome10.4ERBB2
5leiomyosarcoma10.4
6sarcoma10.4
7teratoma10.4KIT
8urticaria10.4PTGS2
9endometrial stromal sarcoma10.4
10rhabdomyosarcoma10.3
11malignant mixed mullerian tumor10.2ERBB2, KIT
12salivary gland adenoid cystic carcinoma10.2KIT, ERBB2
13factor vii deficiency10.2ERBB2, KIT
14bladder carcinoma in situ10.2ERBB2, PTGS2
15cholangiocarcinoma10.1PTGS2, ERBB2
16wilms tumor10.1
17cardiac tamponade10.1
18neuroendocrine carcinoma10.1
19large cell neuroendocrine carcinoma10.1
20adenosarcoma10.1
21chordoma10.1
22embryonal rhabdomyosarcoma10.1
23pericardial effusion10.1
24uterine sarcoma10.1
25didelphys uterus10.1
26transitional cell carcinoma10.1ERBB2, PTGS2
27piebaldism10.1SNAI2, KIT
28gastric adenocarcinoma10.1ERBB2, PTGS2
29bladder carcinoma10.1ERBB2, ANG
30myelodysplastic syndromes10.0KIT, ANG
31endometriosis10.0PTGS2, ANGPT2
32non-small cell lung carcinoma10.0ERBB2, PTGS2
33glioblastoma10.0ANGPT2, KIT, ERBB2
34stomach cancer9.9ERBB2, ANGPT2, PTGS2
35osteoarthritis9.9ANG, ANGPT2, PTGS2
36rheumatoid arthritis9.8ANG, ANGPT2, PTGS2
37ovarian cancer9.8PTGS2, SNAI2, ERBB2
38liver cancer9.7PTGS2, ANGPT2, SNAI2
39prostate cancer9.7PTGS2, ANGPT2, ANG, ERBB2
40adenocarcinoma9.7PTGS2, ANGPT2, ERBB2
41lung cancer9.6PTGS2, ANGPT2, SNAI2, ERBB2
42melanoma9.6KIT, SNAI2, ANG, ANGPT2
43pancreatic cancer9.6PTGS2, ANG, SNAI2, ERBB2
44tongue squamous cell carcinoma9.4PTGS2, ANGPT2, ANG, SNAI2, ERBB2

Graphical network of the top 20 diseases related to Uterine Carcinosarcoma:



Diseases related to uterine carcinosarcoma

Symptoms for Uterine Carcinosarcoma

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Drugs & Therapeutics for Uterine Carcinosarcoma

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Drug clinical trials:

Search ClinicalTrials for Uterine Carcinosarcoma

Search NIH Clinical Center for Uterine Carcinosarcoma

Genetic Tests for Uterine Carcinosarcoma

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Anatomical Context for Uterine Carcinosarcoma

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MalaCards organs/tissues related to Uterine Carcinosarcoma:

32
Uterus, Lung, Breast

Animal Models for Uterine Carcinosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Uterine Carcinosarcoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8PTGS2, KIT, ERBB2
2MP:00053888.8PTGS2, ANGPT2, KIT, ERBB2
3MP:00053858.5ERBB2, KIT, ANGPT2, PTGS2
4MP:00053798.4PTGS2, SNAI2, KIT, ERBB2
5MP:00053908.4PTGS2, SNAI2, KIT, ERBB2
6MP:00053918.4KIT, SNAI2, ANGPT2, PTGS2
7MP:00053808.4ERBB2, KIT, SNAI2, PTGS2
8MP:00053898.3PTGS2, SNAI2, KIT, ERBB2
9MP:00053868.3ERBB2, KIT, SNAI2, PTGS2
10MP:00053818.0ERBB2, KIT, SNAI2, ANGPT2, PTGS2
11MP:00107718.0PTGS2, ANGPT2, SNAI2, KIT, ERBB2
12MP:00107687.7PTGS2, ANGPT2, SNAI2, KIT, ERBB2

Publications for Uterine Carcinosarcoma

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Articles related to Uterine Carcinosarcoma:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit. (25030547)
2014
2
Case report of uterine carcinosarcoma with incisional site recurrence. (25404826)
2014
3
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report. (25197413)
2014
4
Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. (24020131)
2013
5
The reasonable timing of the adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent: suggestion based on progression patterns. (23865003)
2013
6
Is there an increase in the incidence of uterine carcinosarcoma in north-east Scotland? A 19 years population-based cohort study. (23728753)
2013
7
Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma. (23443531)
2013
8
A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: a Gynecologic Oncology Group study. (22796461)
2012
9
Uterine carcinosarcoma with scalp metastasis; a rare presentation. (22214642)
2012
10
Phase II trial of adjuvant pelvic radiation "sandwiched" between ifosfamide or ifosfamide plus cisplatin in women with uterine carcinosarcoma. (22055846)
2012
11
Uterine carcinosarcoma associated with pelvic radiotherapy for sacral chordoma: a case report. (22482976)
2012
12
Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. (21631643)
2011
13
An update on the management of uterine carcinosarcoma. (22186602)
2011
14
Expression and localization of E-cadherin and I^-catenin in uterine carcinosarcoma. (21046151)
2011
15
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat. (22272045)
2011
16
Uterine carcinosarcoma. (21743326)
2011
17
Stage III uterine carcinosarcoma: 2009 International Federation of Gynecology and Obstetrics Staging System and Prognostic Determinants. (21720252)
2011
18
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. (21249682)
2011
19
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. (20605134)
2010
20
Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma. (19276676)
2009
21
Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma. (18548260)
2009
22
Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. (19640575)
2009
23
Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma. (19309402)
2009
24
Evaluation of prognostic factors and treatment outcomes in uterine carcinosarcoma. (19201517)
2009
25
The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. (18160157)
2008
26
Immunohistochemical analysis of carcinomatous and sarcomatous components in the uterine carcinosarcoma: a case report. (18207653)
2008
27
Prognostic factors and adjuvant therapy in uterine carcinosarcoma. (19051818)
2008
28
A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma. (18755503)
2008
29
Immunohistochemical study of DNA topoisomerase I, p53, and Ki-67 in uterine carcinosarcomas. (17490723)
2007
30
Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer. (17666659)
2007
31
The uterine carcinosarcoma - a case report. (18060197)
2007
32
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. (16810312)
2006
33
Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment? (16445668)
2006
34
Importance of the endometrioid carcinoma subtype and sarcomatous component in uterine carcinosarcoma. (15047252)
2004
35
An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. (15362375)
2004
36
Uterine carcinosarcoma with complete sarcomatous overgrowth mimicking pure embryonal rhabdomyosarcoma. (12496704)
2003
37
Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. (14611676)
2003
38
Cure of metastatic uterine carcinosarcoma to lungs: a case report. (12631227)
2003
39
Adjuvant pelvic radiotherapy for uterine carcinosarcoma in a high risk population. (11373106)
2001
40
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. (11585418)
2001
41
Differential expression of matrix metalloprotease-7 in each component of uterine carcinosarcoma. (11032915)
2000
42
Long-term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case-reports and review of the literature. (10928144)
2000
43
Diagnosis of recurrent uterine carcinosarcoma by fine-needle aspiration cytology: report of a case. (10888756)
2000
44
Neovascularization of uterine carcinosarcoma: report of two cases analyzed by color Doppler ultrasonography and microvessel density. (10206221)
1999
45
Prognostic factors in uterine carcinosarcoma: a clinicopathologic study of 25 patients. (9452269)
1998
46
Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. (9311600)
1997
47
Uterine carcinosarcoma in association with tamoxifen therapy. (9197885)
1997
48
The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma. (9190981)
1997
49
Tissue polypeptide antigen production in a uterine carcinosarcoma cell line in a serum-free culture. (8774655)
1996
50
Uterine carcinosarcoma. Case report. (2627972)
1989

Variations for Uterine Carcinosarcoma

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Expression for genes affiliated with Uterine Carcinosarcoma

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Expression patterns in normal tissues for genes affiliated with Uterine Carcinosarcoma

Search GEO for disease gene expression data for Uterine Carcinosarcoma.

Pathways for genes affiliated with Uterine Carcinosarcoma

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Pathways related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signal transduction PTEN pathway60
9.6KIT, ERBB2
29.5KIT, PTGS2
39.5ANGPT2, ERBB2
49.4ANGPT2, PTGS2
5
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
9.2SNAI2, KIT
69.2ERBB2, SNAI2
7
Show member pathways
9.1PTGS2, KIT, ERBB2
89.1ERBB2, KIT, PTGS2
99.1ERBB2, KIT, ANGPT2
10
Show member pathways
9.1KIT, ANGPT2, ERBB2
11
Show member pathways
9.1KIT, ANGPT2, ERBB2
12
Show member pathways
8.6KIT, ERBB2, PTGS2, ANGPT2
13
Show member pathways
8.3SNAI2, KIT, ERBB2, ANGPT2
14
Show member pathways
7.7SNAI2, PTGS2, ANGPT2, ERBB2, KIT

Compounds for genes affiliated with Uterine Carcinosarcoma

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Compounds related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1capecitabine44 50 1112.0ERBB2, KIT
2everolimus44 50 1112.0ERBB2, KIT
3sunitinib44 50 1111.9ERBB2, KIT
417-(allylamino)-17-demethoxygeldanamycin449.9ERBB2, KIT
5flavopiridol44 1110.9ERBB2, KIT
6geldanamycin44 50 61 1112.9ERBB2, KIT
7exemestane44 50 61 1112.8PTGS2, ERBB2
8ag 1478449.8ERBB2, PTGS2
9progestin449.8ERBB2, ANGPT2
10p002449.8ERBB2, KIT
11gemcitabine44 50 1111.7PTGS2, ERBB2
12docetaxel44 50 61 1112.7KIT, ERBB2
13resveratrol44 61 24 1112.6ERBB2, PTGS2
14egcg449.5ERBB2, PTGS2
15erlotinib44 50 1111.5PTGS2, KIT, ERBB2
16trastuzumab44 50 1111.5ERBB2, KIT, ANGPT2
17gefitinib44 50 1111.5PTGS2, KIT, ERBB2
18irinotecan44 50 1111.5ERBB2, KIT, PTGS2
19paraffin449.4ERBB2, KIT, ANGPT2
20herbimycin a44 6110.4ERBB2, PTGS2
21cycloheximide449.4PTGS2, KIT, ERBB2
22celecoxib44 61 28 50 24 1114.4ERBB2, ANGPT2, PTGS2
23steroid449.3ANGPT2, KIT, ERBB2
24formaldehyde44 2410.3KIT, ERBB2
25ly294002449.3PTGS2, ANGPT2, ERBB2
26phosphatidylinositol449.3ANGPT2, KIT, ERBB2
27dexamethasone44 50 28 1112.2ERBB2, ANGPT2, PTGS2
28oxygen44 249.8ANG, ANGPT2, PTGS2
29nitric oxide44 24 1110.8PTGS2, ANGPT2, ANG, KIT
30vegf448.3ERBB2, KIT, ANG, ANGPT2, PTGS2
31estrogen448.1PTGS2, ANGPT2, SNAI2, KIT, ERBB2
32tyrosine448.0ANGPT2, ANG, SNAI2, KIT, ERBB2

GO Terms for genes affiliated with Uterine Carcinosarcoma

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Cellular components related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.5ERBB2, SNAI2, ANG, ANGPT2, PTGS2

Biological processes related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:0230149.8KIT, ERBB2
2peptidyl-tyrosine phosphorylationGO:0181089.7KIT, ERBB2
3protein autophosphorylationGO:0467779.6ERBB2, KIT
4ovarian follicle developmentGO:0015419.6KIT, ANG
5phosphatidylinositol-mediated signalingGO:0480159.5ERBB2, KIT
6pigmentationGO:0434739.4KIT, SNAI2
7positive regulation of cell migrationGO:0303359.2KIT, SNAI2
8response to hypoxiaGO:0016669.0ANG, ANGPT2
9angiogenesisGO:0015259.0ANG, ANGPT2, PTGS2

Molecular functions related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:0047169.6ERBB2, KIT
2protein tyrosine kinase activityGO:0047139.6ERBB2, KIT
3transmembrane receptor protein tyrosine kinase activityGO:0047149.5ERBB2, KIT
4metal ion bindingGO:0468727.9PTGS2, ANGPT2, SNAI2, KIT

Products for genes affiliated with Uterine Carcinosarcoma

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Sources for Uterine Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet