MCID: UTR024
MIFTS: 44

Uterine Carcinosarcoma malady

Cancer category

Summaries for Uterine Carcinosarcoma

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33MalaCards
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MalaCards: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to uterine sarcoma and endometrial stromal sarcoma. An important gene associated with Uterine Carcinosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Adherens junction and GPCR Pathway. The compounds cycloheximide and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lung and breast, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Uterine Carcinosarcoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

uterine carcinosarcoma 8 45 61
mixed mullerian sarcoma of uterus 8


External Ids:

Disease Ontology8 DOID:6171
NCIt40 C42700

Related Diseases for Uterine Carcinosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Uterine Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1uterine sarcoma30.8KIT, MME, DES
2endometrial stromal sarcoma30.3ESR2, KIT, MME, DES, VIM
3adenosarcoma30.1MME, DES
4neuroendocrine carcinoma30.1KIT, MMP7, MUC1
5wilms tumor30.1MME, DES, CTNNB1, VIM
6colorectal cancer30.1ESR2, ERBB2, PTGS2, MMP7, MKI67, ANGPT2
7uterine disease10.2
8cardiac tamponade10.1
9large cell carcinoma10.1
10embryonal sarcoma10.1
11didelphys uterus10.1
12ductal carcinoma in situ10.0ERBB2
13esophageal cancer10.0PTGS2
14biliary tract cancer10.0ERBB2
15stomach cancer10.0ERBB2
16teratoma10.0KIT
17thyroid cancer10.0ANGPT2
18hemangioma10.0ANGPT2
19hepatitis c10.0MMP7
20germ cell tumors10.0KIT
21li-fraumeni syndrome10.0ERBB2
22cystadenoma10.0MME
23renal oncocytoma10.0S100A1
24liver cirrhosis10.0MMP7
25hemangioblastoma10.0MUC1
26lymphangioleiomyomatosis10.0DES
27papilloma10.0RB1
28sertoli-leydig cell tumor10.0MUC1
29hypertension10.0MME
30diabetic retinopathy10.0ANGPT2
31primary hyperoxaluria10.0PTGS2
32craniopharyngioma10.0CTNNB1
33peritonitis10.0MUC16
34prolactinoma10.0ESR2
35nephroblastoma10.0CTNNB1
36infantile myofibromatosis10.0DES
37hidradenoma10.0MUC1
38hepatitis b10.0TOP1
39keratoacanthoma10.0MKI67
40germ cell cancer10.0ESR2
41carney triad10.0KIT
42pericardial effusion10.0MUC16
43benign meningioma10.0MKI67
44gastritis10.0PTGS2, MMP7
45adenomatoid tumor10.0VIM
46arthritis10.0ESR2, PTGS2
47proteinuria10.0ANGPT2
48meigs syndrome10.0MUC16
49thymic carcinoma10.0KIT, MUC1
50fibrous meningioma10.0MUC1

Graphical network of the top 20 diseases related to Uterine Carcinosarcoma:



Diseases related to uterine carcinosarcoma

Clinical Features for Uterine Carcinosarcoma

Drugs & Therapeutics for Uterine Carcinosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uterine Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Uterine Carcinosarcoma

Search NIH Clinical Center for Uterine Carcinosarcoma

Search CenterWatch for Uterine Carcinosarcoma

Genetic Tests for Uterine Carcinosarcoma

Anatomical Context for Uterine Carcinosarcoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Uterine Carcinosarcoma:

33
Whole blood, Lung, Breast, Uterus, Testis, Cervix, Endothelial, Uterus corpus

Animal Models for Uterine Carcinosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Uterine Carcinosarcoma

Sources:
51PubMed
See all sources

Articles related to Uterine Carcinosarcoma:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
2
AlloDerm graft mimicking uterine carcinosarcoma recurrence on PET/CT. (24359070)
2014
3
Is there an increase in the incidence of uterine carcinosarcoma in north-east Scotland? A 19 years population-based cohort study. (23728753)
2013
4
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
5
Prognostic factors and status of hormone receptors and angiogenic factors in uterine carcinosarcoma. (24320058)
2013
6
TGFI^-pathway is down-regulated in a uterine carcinosarcoma: a case study. (23932095)
2013
7
Iniparib plus paclitaxel and carboplatin as initial treatment of advanced or recurrent uterine carcinosarcoma: a Gynecologic Oncology Group Study. (22634397)
2012
8
Identification of suitable reference genes for gene expression measurement in uterine sarcoma and carcinosarcoma tumors. (22266404)
2012
9
A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma. (22727985)
2012
10
Carcinosarcoma arising in a uterine leiomyoma: report of a unique neoplasm. (21979594)
2011
11
Expression and localization of E-cadherin and I^-catenin in uterine carcinosarcoma. (21046151)
2011
12
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat. (22272045)
2011
13
Long-term recurrence-free survival in a patient with stage IVB uterine carcinosarcoma. (22247807)
2011
14
Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers. (21161468)
2011
15
CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed MA1llerian tumor). (21919130)
2011
16
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. (20605134)
2010
17
Prediction of Chemotherapy Response With Platinum and Taxane in the Advanced Stage of Ovarian and Uterine Carcinosarcoma: A Clinical Implication of In vitro Drug Resistance Assay. (19875949)
2010
18
Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. (19640575)
2009
19
Investigation of biological features of uterine carcinosarcoma]. (20210020)
2009
20
Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug. (19389926)
2009
21
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. (19200930)
2009
22
The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. (18160157)
2008
23
Prognostic factors and adjuvant therapy in uterine carcinosarcoma. (19051818)
2008
24
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
25
Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: a SEER analysis. (18674808)
2008
26
18F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma. (17952435)
2008
27
The uterine carcinosarcoma - a case report. (18060197)
2007
28
Uterine carcinosarcoma: immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. (17175012)
2007
29
Overexpression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas. (17545541)
2007
30
Occult metastatic lung carcinoma presenting as locally advanced uterine carcinosarcoma on positron emission tomography/computed tomography imaging. (17504386)
2007
31
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. (16810312)
2006
32
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
33
Uterine carcinosarcoma arising from an endometrial polyp: assessment by 3-dimensional power Doppler angiography and positron emission tomography/computed tomography. (16632794)
2006
34
Differential diagnosis between uterine carcinosarcoma versus carcinoma with sarcomatous metaplasia: an immunohistochemical and ultrastructural case study. (16028671)
2005
35
COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? (15589595)
2005
36
An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. (15362375)
2004
37
Expression of p27 and p53: comparative analysis of uterine carcinosarcoma and endometrial carcinoma. (15086737)
2004
38
Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. (14611676)
2003
39
Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas. (12209997)
2002
40
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. (11585418)
2001
41
Uterine carcinosarcoma with melanocytic differentiation. (11293166)
2001
42
Differential expression of matrix metalloprotease-7 in each component of uterine carcinosarcoma. (11032915)
2000
43
Prognostic factors in uterine carcinosarcoma: a clinicopathologic study of 25 patients. (9452269)
1998
44
Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. (9311600)
1997
45
Uterine carcinosarcoma in association with tamoxifen therapy. (9197885)
1997
46
The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma. (9190981)
1997
47
An evaluation of prognostic factors in uterine carcinosarcoma. (9441781)
1997
48
Tissue polypeptide antigen production in a uterine carcinosarcoma cell line in a serum-free culture. (8774655)
1996
49
Uterine carcinosarcoma. Case report. (2627972)
1989
50
Histogenesis and culture of human uterine carcinosarcoma. (7194144)
1981

Genetic Variations for Uterine Carcinosarcoma

Expression for genes affiliated with Uterine Carcinosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uterine Carcinosarcoma

Search GEO for disease gene expression data for Uterine Carcinosarcoma.

Pathways for genes affiliated with Uterine Carcinosarcoma

Sources:
30KEGG, 52QIAGEN, 4Cell Signaling Technology, 38NCBI BioSystems Database, 56SinoBiological, 12EMD Millipore
See all sources

Compounds for genes affiliated with Uterine Carcinosarcoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7MME
2resveratrol45 60 11 2413.3ERBB2
3glycogen45 2411.1MKI67, CTNNB1, KIT
4toluidine4510.0S100A1, DES, KIT, VIM
5irinotecan45 50 1112.0MKI67, TOP1, ERBB2, KIT
6trastuzumab45 50 1111.9ERBB2, KIT, MUC1, ANGPT2, CTNNB1
7mucicarmine459.9MUC1, DES, VIM, S100A1
8glucose459.8MUC1, MUC16, ANGPT2, MMP7
9celecoxib45 60 29 50 11 2414.8CTNNB1, PTGS2, ANGPT2, MKI67, ERBB2
10paclitaxel45 50 1111.7ERBB2, MUC16, RB1, CTNNB1, TOP1
11progestin459.7ERBB2, MUC1, ANGPT2, DES, ESR2, VIM
12crcs459.6CTNNB1, RB1, MUC1, MME
13cytarabine45 50 1111.6VIM, KIT, TOP1, RB1, MME, MUC1
14b 723459.6S100A1, MUC1, VIM, DES, MUC16
15dexamethasone45 50 29 1112.6MUC16, ANGPT2, RB1, CTNNB1, MME, PTGS2
16gefitinib45 50 1111.6KIT, VIM, CTNNB1, TOP1, PTGS2, ERBB2
17mifepristone45 60 29 1112.5CTNNB1, ESR2, PTGS2, MUC1, MKI67
18etoposide45 50 60 1112.5RB1, TOP1, ERBB2, VIM, ESR2
19thymidylate459.5MKI67, RB1, TOP1, VIM, ERBB2, ESR2
20p002459.5MMP7, CTNNB1, RB1, DES, MKI67, KIT
21serine459.5ESR2, MUC16, ERBB2, CLDN4, DES, MKI67
22methotrexate45 50 1111.5ERBB2, KIT, MUC1, MKI67, RB1, VIM
23bromodeoxyuridine459.4MME, MKI67, DES, RB1, CTNNB1, VIM
24agar459.4RB1, ERBB2, CTNNB1, TOP1, VIM, MUC1
25gnrh459.4MKI67, CTNNB1, VIM, MME, ERBB2, ESR2
265fluorouracil459.4CTNNB1, TOP1, MKI67, MUC1, KIT, RB1
27steroid459.3DES, MUC16, MME, ERBB2, MKI67, ANGPT2
28ribonucleic acid459.3MMP7, ANGPT2, MUC1, MME, ESR2, KIT
29oxygen45 2410.3MME, ANGPT2, DES, RB1, MKI67, MUC1
30adriamycin459.3RB1, MUC1, ERBB2, DES, MME, CTNNB1
31matrigel459.3MUC1, MMP7, VIM, CTNNB1, RB1, SNAI2
32estradiol45 11 2411.3MUC16, VIM, MKI67, RB1, ESR2, DES
33formaldehyde45 2410.3VIM, ERBB2, KIT, MUC1, MKI67, TOP1
34hematoxylin459.2S100A1, VIM, MKI67, MUC16, MUC1, KIT
35thymidine45 2410.2RB1, CTNNB1, KIT, MME, MUC1, MKI67
36actinomycin d459.2PTGS2, KIT, MME, MUC1, DES, TOP1
37biotin45 11 2411.1VIM, ERBB2, MUC1, RB1, CTNNB1, S100A1
38lactate459.1ERBB2, KIT, MME, MUC16, MKI67, DES
39vincristine45 50 1111.1VIM, RB1, TOP1, MKI67, KIT
40cisplatin45 50 60 1112.0RB1, TOP1, MKI67, CTNNB1, ERBB2, PTGS2
41nitric oxide45 11 2410.7ANGPT2, S100A1, RB1, DES, ANG, MKI67
42cysteine458.6VIM, S100A1, CTNNB1, RB1, DES, ANGPT2
43h2o2458.6VIM, RB1, ESR2, MME, CTNNB1, DES
44testosterone45 60 11 2411.5MKI67, MUC1, MME, KIT, ERBB2, VIM
45doxorubicin45 50 1110.4MME, MUC16, MKI67, DES, TOP1, RB1
46retinoic acid45 249.4ANGPT2, ESR2, VIM, KIT, MMP7, MME
47paraffin457.9MUC1, MUC16, MKI67, ANGPT2, DES, RB1
48progesterone45 60 29 11 2411.8RB1, DES, MKI67, MUC16, MUC1, CLDN4
49tyrosine457.8KIT, MMP7, SNAI2, MME, CLDN4, MUC1
50vegf457.7MUC1, VIM, CTNNB1, RB1, DES, ANG

GO Terms for genes affiliated with Uterine Carcinosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.1DES, CTNNB1
2nucleusGO:0056347.8ESR2, S100A1, CTNNB1, RB1, SNAI2, TOP1

Biological processes related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:02301410.1ERBB2, KIT
2negative regulation of chondrocyte differentiationGO:03233110.1SNAI2, CTNNB1
3ovarian follicle developmentGO:00154110.0ESR2, KIT, ANG
4response to drugGO:0424939.4CTNNB1, TOP1, MMP7, PTGS2

Molecular functions related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.2ERBB2, KIT
2protein C-terminus bindingGO:0080229.3ERBB2, MKI67, CTNNB1, VIM
3identical protein bindingGO:0428028.9ERBB2, VIM, S100A1, RB1, DES, CLDN3
4protein bindingGO:0055157.2DES, TOP1, RB1, CTNNB1, S100A1, VIM

Products for genes affiliated with Uterine Carcinosarcoma

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  • Proteins
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Sources for Uterine Carcinosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet