MCID: UTR024
MIFTS: 38

Uterine Carcinosarcoma malady

Cancer diseases category

Aliases & Classifications for Uterine Carcinosarcoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt
See all sources

Uterine Carcinosarcoma, Aliases & Descriptions:

Name: Uterine Carcinosarcoma 9 43 60
Mixed Mullerian Sarcoma of Uterus 9
 
Uterine Corpus Carcinosarcoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:6171
NCIt38 C42700

Summaries for Uterine Carcinosarcoma

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Disease Ontology:9 A uterine body mixed cancer that has material basis in both endometrial carcinoma and sarcoma.

MalaCards based summary: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to breast cancer and colorectal cancer. An important gene associated with Uterine Carcinosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Endometrial cancer and C-MYB transcription factor network. The compounds capecitabine and everolimus have been mentioned in the context of this disorder. Affiliated tissues include uterus, lung and breast, and related mouse phenotypes are tumorigenesis and respiratory system.

Related Diseases for Uterine Carcinosarcoma

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Diseases related to Uterine Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.5PTGS2, ERBB2
2colorectal cancer30.1ANGPT2, PTGS2, ERBB2
3leiomyosarcoma10.4
4sarcoma10.4
5breast disease10.4ERBB2
6teratoma10.4KIT
7endometrial stromal sarcoma10.4
8urticaria10.4PTGS2
9rhabdomyosarcoma10.3
10malignant mixed mullerian tumor10.2ERBB2, KIT
11salivary gland adenoid cystic carcinoma10.2KIT, ERBB2
12factor vii deficiency10.2ERBB2, KIT
13cholangiocarcinoma10.1ERBB2, PTGS2
14wilms tumor10.1
15neuroendocrine carcinoma10.1
16large cell neuroendocrine carcinoma10.1
17cardiac tamponade10.1
18adenosarcoma10.1
19chordoma10.1
20embryonal rhabdomyosarcoma10.1
21pericardial effusion10.1
22uterine sarcoma10.1
23didelphys uterus10.1
24endotheliitis10.1
25transitional cell carcinoma10.1ERBB2, PTGS2
26piebaldism10.1KIT, SNAI2
27gastric adenocarcinoma10.1PTGS2, ERBB2
28bladder cancer, somatic10.1ERBB2, ANG
29myelodysplastic syndrome10.0KIT, ANG
30endometriosis10.0ANGPT2, PTGS2
31lung cancer10.0PTGS2, ERBB2
32glioblastoma10.0ERBB2, ANGPT2, KIT
33endometrial cancer9.9ANGPT2, ANG, ERBB2
34gastric cancer, somatic9.9ERBB2, ANGPT2, PTGS2
35osteoarthritis9.9PTGS2, ANG, ANGPT2
36rheumatoid arthritis9.8PTGS2, ANGPT2, ANG
37ovarian cancer, somatic9.8PTGS2, SNAI2, ERBB2
38hepatocellular carcinoma9.7SNAI2, ANGPT2, PTGS2
39stomach cancer9.7ERBB2, ANGPT2, ANG, PTGS2
40prostate cancer9.7PTGS2, ANG, ANGPT2, ERBB2
41adenocarcinoma9.7ERBB2, ANGPT2, PTGS2
42melanoma9.6KIT, ANGPT2, SNAI2, ANG
43pancreatic cancer9.6PTGS2, ERBB2, SNAI2, ANG
44tongue squamous cell carcinoma9.4SNAI2, ANG, PTGS2, ANGPT2, ERBB2

Graphical network of the top 20 diseases related to Uterine Carcinosarcoma:



Diseases related to uterine carcinosarcoma

Symptoms for Uterine Carcinosarcoma

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Drugs & Therapeutics for Uterine Carcinosarcoma

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Drug clinical trials:

Search ClinicalTrials for Uterine Carcinosarcoma

Search NIH Clinical Center for Uterine Carcinosarcoma

Genetic Tests for Uterine Carcinosarcoma

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Anatomical Context for Uterine Carcinosarcoma

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MalaCards organs/tissues related to Uterine Carcinosarcoma:

31
Uterus, Lung, Breast, Endothelial

Animal Models for Uterine Carcinosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Uterine Carcinosarcoma:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8PTGS2, KIT, ERBB2
2MP:00053888.8PTGS2, ANGPT2, KIT, ERBB2
3MP:00053858.5ERBB2, KIT, ANGPT2, PTGS2
4MP:00053798.4PTGS2, SNAI2, KIT, ERBB2
5MP:00053908.4PTGS2, SNAI2, KIT, ERBB2
6MP:00053918.4KIT, SNAI2, ANGPT2, PTGS2
7MP:00053808.4ERBB2, KIT, SNAI2, PTGS2
8MP:00053898.3PTGS2, SNAI2, KIT, ERBB2
9MP:00053868.3ERBB2, KIT, SNAI2, PTGS2
10MP:00053818.0ERBB2, KIT, SNAI2, ANGPT2, PTGS2
11MP:00107718.0PTGS2, ANGPT2, SNAI2, KIT, ERBB2
12MP:00107687.7PTGS2, ANGPT2, SNAI2, KIT, ERBB2

Publications for Uterine Carcinosarcoma

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Articles related to Uterine Carcinosarcoma:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Uterine carcinosarcoma: A review of the literature. (25805398)
2015
2
Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit. (25030547)
2014
3
Case report of uterine carcinosarcoma with incisional site recurrence. (25404826)
2014
4
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report. (25197413)
2014
5
Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. (24020131)
2013
6
The reasonable timing of the adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent: suggestion based on progression patterns. (23865003)
2013
7
Is there an increase in the incidence of uterine carcinosarcoma in north-east Scotland? A 19 years population-based cohort study. (23728753)
2013
8
Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma. (23443531)
2013
9
A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: a Gynecologic Oncology Group study. (22796461)
2012
10
Uterine carcinosarcoma with scalp metastasis; a rare presentation. (22214642)
2012
11
Phase II trial of adjuvant pelvic radiation "sandwiched" between ifosfamide or ifosfamide plus cisplatin in women with uterine carcinosarcoma. (22055846)
2012
12
Uterine carcinosarcoma associated with pelvic radiotherapy for sacral chordoma: a case report. (22482976)
2012
13
Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. (21631643)
2011
14
An update on the management of uterine carcinosarcoma. (22186602)
2011
15
Expression and localization of E-cadherin and I^-catenin in uterine carcinosarcoma. (21046151)
2011
16
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat. (22272045)
2011
17
Uterine carcinosarcoma. (21743326)
2011
18
Stage III uterine carcinosarcoma: 2009 International Federation of Gynecology and Obstetrics Staging System and Prognostic Determinants. (21720252)
2011
19
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. (21249682)
2011
20
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. (20605134)
2010
21
Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma. (19276676)
2009
22
Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma. (18548260)
2009
23
Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. (19640575)
2009
24
Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma. (19309402)
2009
25
Evaluation of prognostic factors and treatment outcomes in uterine carcinosarcoma. (19201517)
2009
26
The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. (18160157)
2008
27
Immunohistochemical analysis of carcinomatous and sarcomatous components in the uterine carcinosarcoma: a case report. (18207653)
2008
28
Prognostic factors and adjuvant therapy in uterine carcinosarcoma. (19051818)
2008
29
A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma. (18755503)
2008
30
Immunohistochemical study of DNA topoisomerase I, p53, and Ki-67 in uterine carcinosarcomas. (17490723)
2007
31
Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer. (17666659)
2007
32
The uterine carcinosarcoma - a case report. (18060197)
2007
33
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. (16810312)
2006
34
Expression and amplification of HER-2/neu oncogene in uterine carcinosarcomas: a marker for potential molecularly targeted treatment? (16445668)
2006
35
Importance of the endometrioid carcinoma subtype and sarcomatous component in uterine carcinosarcoma. (15047252)
2004
36
An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. (15362375)
2004
37
Uterine carcinosarcoma with complete sarcomatous overgrowth mimicking pure embryonal rhabdomyosarcoma. (12496704)
2003
38
Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. (14611676)
2003
39
Cure of metastatic uterine carcinosarcoma to lungs: a case report. (12631227)
2003
40
Adjuvant pelvic radiotherapy for uterine carcinosarcoma in a high risk population. (11373106)
2001
41
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. (11585418)
2001
42
Differential expression of matrix metalloprotease-7 in each component of uterine carcinosarcoma. (11032915)
2000
43
Long-term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case-reports and review of the literature. (10928144)
2000
44
Diagnosis of recurrent uterine carcinosarcoma by fine-needle aspiration cytology: report of a case. (10888756)
2000
45
Neovascularization of uterine carcinosarcoma: report of two cases analyzed by color Doppler ultrasonography and microvessel density. (10206221)
1999
46
Prognostic factors in uterine carcinosarcoma: a clinicopathologic study of 25 patients. (9452269)
1998
47
Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. (9311600)
1997
48
Uterine carcinosarcoma in association with tamoxifen therapy. (9197885)
1997
49
The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma. (9190981)
1997
50
Uterine carcinosarcoma. Case report. (2627972)
1989

Variations for Uterine Carcinosarcoma

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Expression for genes affiliated with Uterine Carcinosarcoma

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Search GEO for disease gene expression data for Uterine Carcinosarcoma.

Pathways for genes affiliated with Uterine Carcinosarcoma

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Pathways related to Uterine Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signal transduction PTEN pathway58
9.6ERBB2, KIT
29.5KIT, PTGS2
39.5ERBB2, ANGPT2
49.4ANGPT2, PTGS2
5
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.2KIT, SNAI2
69.2SNAI2, ERBB2
7
Show member pathways
9.1PTGS2, KIT, ERBB2
89.1ERBB2, KIT, PTGS2
99.1ANGPT2, KIT, ERBB2
10
Show member pathways
9.1ERBB2, KIT, ANGPT2
11
Show member pathways
9.1ANGPT2, KIT, ERBB2
12
Show member pathways
8.6PTGS2, ANGPT2, KIT, ERBB2
13
Show member pathways
8.3ANGPT2, SNAI2, KIT, ERBB2
14
Show member pathways
7.7ERBB2, KIT, SNAI2, ANGPT2, PTGS2

Compounds for genes affiliated with Uterine Carcinosarcoma

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Compounds related to Uterine Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1capecitabine43 49 1212.0ERBB2, KIT
2everolimus43 49 1212.0ERBB2, KIT
3sunitinib43 49 1211.9ERBB2, KIT
417-(allylamino)-17-demethoxygeldanamycin439.9ERBB2, KIT
5flavopiridol43 1210.9ERBB2, KIT
6geldanamycin43 49 59 1212.9ERBB2, KIT
7exemestane43 49 59 1212.8PTGS2, ERBB2
8ag 1478439.8ERBB2, PTGS2
9progestin439.8ERBB2, ANGPT2
10p002439.8ERBB2, KIT
11gemcitabine43 49 1211.7PTGS2, ERBB2
12docetaxel43 49 59 1212.7KIT, ERBB2
13resveratrol43 59 24 1212.6ERBB2, PTGS2
14egcg439.5ERBB2, PTGS2
15erlotinib43 49 1211.5PTGS2, KIT, ERBB2
16trastuzumab43 49 1211.5ERBB2, KIT, ANGPT2
17gefitinib43 49 1211.5PTGS2, KIT, ERBB2
18irinotecan43 49 1211.5ERBB2, KIT, PTGS2
19paraffin439.4ERBB2, KIT, ANGPT2
20herbimycin a43 5910.4ERBB2, PTGS2
21cycloheximide439.4PTGS2, KIT, ERBB2
22celecoxib43 59 28 49 24 1214.4ERBB2, ANGPT2, PTGS2
23steroid439.3ANGPT2, KIT, ERBB2
24formaldehyde43 2410.3KIT, ERBB2
25ly294002439.3PTGS2, ANGPT2, ERBB2
26phosphatidylinositol439.3ANGPT2, KIT, ERBB2
27dexamethasone43 49 28 1212.2ERBB2, ANGPT2, PTGS2
28oxygen43 249.8ANG, ANGPT2, PTGS2
29nitric oxide43 24 1210.8PTGS2, ANGPT2, ANG, KIT
30vegf438.3ERBB2, KIT, ANG, ANGPT2, PTGS2
31estrogen438.1PTGS2, ANGPT2, SNAI2, KIT, ERBB2
32tyrosine438.0ANGPT2, ANG, SNAI2, KIT, ERBB2

GO Terms for genes affiliated with Uterine Carcinosarcoma

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Cellular components related to Uterine Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.5ERBB2, SNAI2, ANG, ANGPT2, PTGS2

Biological processes related to Uterine Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:00230149.8KIT, ERBB2
2peptidyl-tyrosine phosphorylationGO:00181089.7KIT, ERBB2
3protein autophosphorylationGO:00467779.6ERBB2, KIT
4ovarian follicle developmentGO:00015419.6KIT, ANG
5phosphatidylinositol-mediated signalingGO:00480159.5ERBB2, KIT
6pigmentationGO:00434739.4KIT, SNAI2
7positive regulation of cell migrationGO:00303359.2KIT, SNAI2
8response to hypoxiaGO:00016669.0ANG, ANGPT2
9angiogenesisGO:00015259.0ANG, ANGPT2, PTGS2

Molecular functions related to Uterine Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00047169.6ERBB2, KIT
2protein tyrosine kinase activityGO:00047139.6ERBB2, KIT
3transmembrane receptor protein tyrosine kinase activityGO:00047149.5ERBB2, KIT
4metal ion bindingGO:00468727.9PTGS2, ANGPT2, SNAI2, KIT

Products for genes affiliated with Uterine Carcinosarcoma

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  • Antibodies
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  • Kits and Assays

Sources for Uterine Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet