MCID: UTR024
MIFTS: 49

Uterine Carcinosarcoma malady

Cancer diseases category

Summaries for Uterine Carcinosarcoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Uterine Carcinosarcoma, also known as mixed mullerian sarcoma of uterus, is related to leiomyosarcoma and sarcoma. An important gene associated with Uterine Carcinosarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Adherens junction and GPCR Pathway. The compounds cycloheximide and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include uterus, lung and cervix, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Uterine Carcinosarcoma

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

uterine carcinosarcoma 8 44 60
mixed mullerian sarcoma of uterus 8


External Ids:

Disease Ontology8 DOID:6171
NCIt39 C42700

Related Diseases for Uterine Carcinosarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Uterine Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.4KIT, MME, MUC1, MUC16, DES, RB1
2sarcoma30.4KIT, MMP7, MUC1, MKI67, ANGPT2, DES
3endometrial stromal sarcoma30.3ESR2, KIT, MME, DES, VIM
4rhabdomyosarcoma30.3DES, TOP1, RB1, S100A1, VIM
5endometrial carcinoma30.3ESR2, ERBB2, MME, CLDN4, CLDN3, MUC16
6pericardial effusion30.1MUC16
7adenosarcoma30.1MME, DES
8neuroendocrine carcinoma30.1KIT, MMP7, MUC1
9chordoma30.1MUC1, DES, S100A1, VIM
10breast cancer30.1ESR2, ERBB2, PTGS2, CTNNB1
11colorectal cancer30.0ESR2, ERBB2, PTGS2, MMP7, MKI67, ANGPT2
12uterine disease10.2
13cardiac tamponade10.1
14large cell carcinoma10.1
15embryonal rhabdomyosarcoma10.1
16lung large cell carcinoma10.1
17ovarian carcinosarcoma10.1
18ductal carcinoma in situ10.0ERBB2
19esophageal cancer10.0PTGS2
20biliary tract neoplasm10.0ERBB2
21stomach cancer10.0ERBB2
22teratoma10.0KIT
23thyroid cancer10.0ANGPT2
24hemangioma10.0ANGPT2
25hepatitis c10.0MMP7
26germ cell tumors10.0KIT
27li-fraumeni syndrome10.0ERBB2
28cystadenoma10.0MME
29renal oncocytoma10.0S100A1
30liver cirrhosis10.0MMP7
31hemangioblastoma10.0MUC1
32lymphangioleiomyomatosis10.0DES
33papilloma10.0RB1
34sertoli-leydig cell tumor10.0MUC1
35hypertension10.0MME
36diabetic retinopathy10.0ANGPT2
37primary hyperoxaluria10.0PTGS2
38craniopharyngioma10.0CTNNB1
39peritonitis10.0MUC16
40prolactinoma10.0ESR2
41nephroblastoma10.0CTNNB1
42hidradenoma10.0MUC1
43infantile myofibromatosis10.0DES
44hepatitis b10.0TOP1
45keratoacanthoma10.0MKI67
46germ cell cancer10.0ESR2
47carney triad10.0KIT
48benign meningioma10.0MKI67
49gastritis10.0PTGS2, MMP7
50adenomatoid tumor10.0VIM

Graphical network of the top 20 diseases related to Uterine Carcinosarcoma:



Diseases related to uterine carcinosarcoma

Clinical Features for Uterine Carcinosarcoma

About this section

Drugs & Therapeutics for Uterine Carcinosarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uterine Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Uterine Carcinosarcoma

Search NIH Clinical Center for Uterine Carcinosarcoma

Search CenterWatch for Uterine Carcinosarcoma

Genetic Tests for Uterine Carcinosarcoma

About this section

Anatomical Context for Uterine Carcinosarcoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Uterine Carcinosarcoma:

32
Uterus, Lung, Cervix, Breast, Testis, Endothelial

Animal Models for Uterine Carcinosarcoma or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Uterine Carcinosarcoma

About this section
Sources:
50PubMed
See all sources

Articles related to Uterine Carcinosarcoma:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
2
Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component. (24033661)
2014
3
Is there an increase in the incidence of uterine carcinosarcoma in north-east Scotland? A 19 years population-based cohort study. (23728753)
2013
4
Metastatic Calcaneal Lesion Associated with Uterine Carcinosarcoma. (23871174)
2013
5
Uterine carcinosarcoma in a patient with didelphys uterus. (23533863)
2013
6
TGFI^-pathway is down-regulated in a uterine carcinosarcoma: a case study. (23932095)
2013
7
A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: a Gynecologic Oncology Group study. (22796461)
2012
8
Phase II trial of adjuvant pelvic radiation "sandwiched" between ifosfamide or ifosfamide plus cisplatin in women with uterine carcinosarcoma. (22055846)
2012
9
Uterine carcinosarcoma associated with pelvic radiotherapy for sacral chordoma: a case report. (22482976)
2012
10
The promoter methylation and expression of the O6-methylguanine-DNA methyltransferase gene in uterine sarcoma and carcinosarcoma. (22970054)
2012
11
A phase II study single agent of aflibercept (VEGF Trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma. A trial of the Princess Margaret Hospital, Chicago and California Cancer Phase II Consortia. (22138373)
2012
12
Prognostic impact of the history of breast cancer and of hormone therapy in uterine carcinosarcoma. (22228427)
2012
13
Carcinosarcoma arising in a uterine leiomyoma: report of a unique neoplasm. (21979594)
2011
14
Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. (21631643)
2011
15
An update on the management of uterine carcinosarcoma. (22186602)
2011
16
Expression and localization of E-cadherin and I^-catenin in uterine carcinosarcoma. (21046151)
2011
17
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat. (22272045)
2011
18
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. (21249682)
2011
19
Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers. (21161468)
2011
20
Uterine carcinosarcoma. (21508698)
2011
21
COX-2 expression in uterine carcinosarcoma. (19900134)
2010
22
Prediction of Chemotherapy Response With Platinum and Taxane in the Advanced Stage of Ovarian and Uterine Carcinosarcoma: A Clinical Implication of In vitro Drug Resistance Assay. (19875949)
2010
23
Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma. (18548260)
2009
24
Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug. (19389926)
2009
25
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. (19200930)
2009
26
Prognostic factors and adjuvant therapy in uterine carcinosarcoma. (19051818)
2008
27
Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: a SEER analysis. (18674808)
2008
28
18F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma. (17952435)
2008
29
Characterization of a newly established uterine carcinosarcoma cell line featuring the sarcomatous phenotype of the tumor in vitro. (18334012)
2008
30
Immunohistochemical study of DNA topoisomerase I, p53, and Ki-67 in uterine carcinosarcomas. (17490723)
2007
31
The uterine carcinosarcoma - a case report. (18060197)
2007
32
Uterine carcinosarcoma: immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. (17175012)
2007
33
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. (16810312)
2006
34
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
35
Uterine carcinosarcoma arising from an endometrial polyp: assessment by 3-dimensional power Doppler angiography and positron emission tomography/computed tomography. (16632794)
2006
36
Expression of c-kit in uterine carcinosarcoma. (15589603)
2005
37
HER-2/neu oncogene in uterine carcinosarcoma on tamoxifen therapy. (15901136)
2005
38
An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. (15362375)
2004
39
Expression of p27 and p53: comparative analysis of uterine carcinosarcoma and endometrial carcinoma. (15086737)
2004
40
Cure of metastatic uterine carcinosarcoma to lungs: a case report. (12631227)
2003
41
Uterine carcinosarcoma related to tamoxifen]. (14675359)
2003
42
Unsuspected uterine carcinosarcoma (heterologous) diagnosed following conservative therapies with medroxyprogesterone acetate for presumed early-stage endometrial carcinoma. (12069197)
2002
43
Adjuvant pelvic radiotherapy for uterine carcinosarcoma in a high risk population. (11373106)
2001
44
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. (11585418)
2001
45
Diagnosis of recurrent uterine carcinosarcoma by fine-needle aspiration cytology: report of a case. (10888756)
2000
46
Prognostic factors in uterine carcinosarcoma: a clinicopathologic study of 25 patients. (9452269)
1998
47
The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma. (9190981)
1997
48
An evaluation of prognostic factors in uterine carcinosarcoma. (9441781)
1997
49
Tissue polypeptide antigen production in a uterine carcinosarcoma cell line in a serum-free culture. (8774655)
1996
50
Uterine carcinosarcoma. Case report. (2627972)
1989

Genetic Variations for Uterine Carcinosarcoma

About this section

Expression for genes affiliated with Uterine Carcinosarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uterine Carcinosarcoma

Search GEO for disease gene expression data for Uterine Carcinosarcoma.

Pathways for genes affiliated with Uterine Carcinosarcoma

About this section
Sources:
29KEGG, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 55SinoBiological, 12EMD Millipore
See all sources

Compounds for genes affiliated with Uterine Carcinosarcoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7MME
2resveratrol44 59 11 2413.3ERBB2
3glycogen44 2411.1MKI67, CTNNB1, KIT
4toluidine4410.0S100A1, DES, KIT, VIM
5irinotecan44 49 1112.0MKI67, TOP1, ERBB2, KIT
6trastuzumab44 49 1111.9ERBB2, KIT, MUC1, ANGPT2, CTNNB1
7mucicarmine449.9MUC1, DES, VIM, S100A1
8glucose449.8MUC1, MUC16, ANGPT2, MMP7
9celecoxib44 59 28 49 11 2414.8CTNNB1, PTGS2, ANGPT2, MKI67, ERBB2
10paclitaxel44 49 1111.7ERBB2, MUC16, RB1, CTNNB1, TOP1
11progestin449.7ERBB2, MUC1, ANGPT2, DES, ESR2, VIM
12crcs449.6CTNNB1, RB1, MUC1, MME
13cytarabine44 49 1111.6VIM, KIT, TOP1, RB1, MME, MUC1
14b 723449.6S100A1, MUC1, VIM, DES, MUC16
15dexamethasone44 49 28 1112.6MUC16, ANGPT2, RB1, CTNNB1, MME, PTGS2
16gefitinib44 49 1111.6KIT, VIM, CTNNB1, TOP1, PTGS2, ERBB2
17mifepristone44 59 28 1112.5CTNNB1, ESR2, PTGS2, MUC1, MKI67
18etoposide44 49 59 1112.5RB1, TOP1, ERBB2, VIM, ESR2
19thymidylate449.5MKI67, RB1, TOP1, VIM, ERBB2, ESR2
20p002449.5MMP7, CTNNB1, RB1, DES, MKI67, KIT
21serine449.5ESR2, MUC16, ERBB2, CLDN4, DES, MKI67
22methotrexate44 49 1111.5ERBB2, KIT, MUC1, MKI67, RB1, VIM
23bromodeoxyuridine449.4MME, MKI67, DES, RB1, CTNNB1, VIM
24agar449.4RB1, ERBB2, CTNNB1, TOP1, VIM, MUC1
25gnrh449.4MKI67, CTNNB1, VIM, MME, ERBB2, ESR2
265fluorouracil449.4CTNNB1, TOP1, MKI67, MUC1, KIT, RB1
27steroid449.3DES, MUC16, MME, ERBB2, MKI67, ANGPT2
28ribonucleic acid449.3MMP7, ANGPT2, MUC1, MME, ESR2, KIT
29oxygen44 2410.3MME, ANGPT2, DES, RB1, MKI67, MUC1
30adriamycin449.3RB1, MUC1, ERBB2, DES, MME, CTNNB1
31matrigel449.3MUC1, MMP7, VIM, CTNNB1, RB1, SNAI2
32estradiol44 11 2411.3MUC16, VIM, MKI67, RB1, ESR2, DES
33formaldehyde44 2410.3VIM, ERBB2, KIT, MUC1, MKI67, TOP1
34hematoxylin449.2S100A1, VIM, MKI67, MUC16, MUC1, KIT
35thymidine44 2410.2RB1, CTNNB1, KIT, MME, MUC1, MKI67
36actinomycin d449.2PTGS2, KIT, MME, MUC1, DES, TOP1
37biotin44 11 2411.1VIM, ERBB2, MUC1, RB1, CTNNB1, S100A1
38lactate449.1ERBB2, KIT, MME, MUC16, MKI67, DES
39vincristine44 49 1111.1VIM, RB1, TOP1, MKI67, KIT
40cisplatin44 49 59 1112.0RB1, TOP1, MKI67, CTNNB1, ERBB2, PTGS2
41nitric oxide44 11 2410.7ANGPT2, S100A1, RB1, DES, ANG, MKI67
42cysteine448.6VIM, S100A1, CTNNB1, RB1, DES, ANGPT2
43h2o2448.6VIM, RB1, ESR2, MME, CTNNB1, DES
44testosterone44 59 11 2411.5MKI67, MUC1, MME, KIT, ERBB2, VIM
45doxorubicin44 49 1110.4MME, MUC16, MKI67, DES, TOP1, RB1
46retinoic acid44 249.4ANGPT2, ESR2, VIM, KIT, MMP7, MME
47paraffin447.9MUC1, MUC16, MKI67, ANGPT2, DES, RB1
48progesterone44 59 28 11 2411.8RB1, DES, MKI67, MUC16, MUC1, CLDN4
49tyrosine447.8KIT, MMP7, SNAI2, MME, CLDN4, MUC1
50vegf447.7MUC1, VIM, CTNNB1, RB1, DES, ANG

GO Terms for genes affiliated with Uterine Carcinosarcoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.1DES, CTNNB1
2nucleusGO:0056347.8ESR2, S100A1, CTNNB1, RB1, SNAI2, TOP1

Biological processes related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:02301410.1ERBB2, KIT
2negative regulation of chondrocyte differentiationGO:03233110.1SNAI2, CTNNB1
3ovarian follicle developmentGO:00154110.0ESR2, KIT, ANG
4response to drugGO:0424939.4CTNNB1, TOP1, MMP7, PTGS2

Molecular functions related to Uterine Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.2ERBB2, KIT
2protein C-terminus bindingGO:0080229.3ERBB2, MKI67, CTNNB1, VIM
3identical protein bindingGO:0428028.9ERBB2, VIM, S100A1, RB1, DES, CLDN3
4protein bindingGO:0055157.2DES, TOP1, RB1, CTNNB1, S100A1, VIM

Products for genes affiliated with Uterine Carcinosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Carcinosarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet