MCID: UTR056
MIFTS: 24

Uterine Corpus Endometrial Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Uterine Corpus Endometrial Carcinoma

MalaCards integrated aliases for Uterine Corpus Endometrial Carcinoma:

Name: Uterine Corpus Endometrial Carcinoma 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050939

Summaries for Uterine Corpus Endometrial Carcinoma

Disease Ontology : 12 A uterine corpus cancer that is derives from the inner lining of the uterus.

MalaCards based summary : Uterine Corpus Endometrial Carcinoma is related to uterine corpus cancer and familial hyperaldosteronism. An important gene associated with Uterine Corpus Endometrial Carcinoma is NCAPH (Non-SMC Condensin I Complex Subunit H), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cell Cycle Checkpoints. Affiliated tissues include uterus, and related phenotypes are Increased cell death HMECs cells and Increased proliferation

Related Diseases for Uterine Corpus Endometrial Carcinoma

Diseases related to Uterine Corpus Endometrial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 uterine corpus cancer 10.1 CDCA8 NCAPH TP53
2 familial hyperaldosteronism 10.0 CYP11B1 CYP11B2
3 hyperaldosteronism, familial, type i 9.9 CYP11B1 CYP11B2
4 organ system benign neoplasm 9.9 CYP11B1 CYP11B2 TP53
5 adrenocortical carcinoma, hereditary 9.8 CYP11B1 CYP11B2 TP53

Graphical network of the top 20 diseases related to Uterine Corpus Endometrial Carcinoma:



Diseases related to Uterine Corpus Endometrial Carcinoma

Symptoms & Phenotypes for Uterine Corpus Endometrial Carcinoma

GenomeRNAi Phenotypes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.35 BUB1 CDC20 MCM6 MELK TP53
2 Increased proliferation GR00094-A 8.62 BUB1 TP53

MGI Mouse Phenotypes related to Uterine Corpus Endometrial Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 CYP11B1 DEGS1 MCM6 NCAPH TP53 TPX2
2 mortality/aging MP:0010768 9.36 BUB1 CCNB2 CDC20 CDCA8 CYP11B1 DEGS1

Drugs & Therapeutics for Uterine Corpus Endometrial Carcinoma

Search Clinical Trials , NIH Clinical Center for Uterine Corpus Endometrial Carcinoma

Genetic Tests for Uterine Corpus Endometrial Carcinoma

Anatomical Context for Uterine Corpus Endometrial Carcinoma

MalaCards organs/tissues related to Uterine Corpus Endometrial Carcinoma:

38
Uterus

Publications for Uterine Corpus Endometrial Carcinoma

Articles related to Uterine Corpus Endometrial Carcinoma:

# Title Authors Year
1
Bioinformatics analysis of RNA sequencing data reveals multiple key genes in uterine corpus endometrial carcinoma. ( 29387216 )
2018
2
Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma. ( 28280730 )
2017

Variations for Uterine Corpus Endometrial Carcinoma

Expression for Uterine Corpus Endometrial Carcinoma

Search GEO for disease gene expression data for Uterine Corpus Endometrial Carcinoma.

Pathways for Uterine Corpus Endometrial Carcinoma

Pathways related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 BUB1 CCNB2 CDC20 CDCA8 MCM6 NCAPG
2
Show member pathways
12.4 CCNB2 CDC20 MCM6 TP53
3 12.16 CCNB2 CDC20 PPP3CA TP53
4
Show member pathways
12.08 BUB1 CCNB2 CDC20 PPP3CA
5 12.01 BUB1 CCNB2 CDC20 MCM6 TP53
6
Show member pathways
11.97 BUB1 CCNB2 CDC20 CDCA8 NCAPG NCAPH
7 11.93 CCNB2 PPP3CA TP53
8 11.65 CCNB2 CDC20 TPX2
9 11.6 CCNB2 MCM6 TP53
10 11.31 BUB1 CCNB2 CDC20
11
Show member pathways
11.26 BUB1 CDC20 TPX2
12 11.05 TP53 TPX2
13 11.02 CCNB2 NCAPG NCAPH
14
Show member pathways
10.88 CYP11B1 CYP11B2
15 10.79 CCNB2 TP53
16
Show member pathways
10.58 BUB1 CDCA8 NCAPG NCAPH

GO Terms for Uterine Corpus Endometrial Carcinoma

Cellular components related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 BUB1 CCNB2 CDC20 CDCA8 MCM6 MELK
2 chromosome GO:0005694 9.46 BUB1 CDCA8 NCAPG NCAPH
3 condensin complex GO:0000796 8.62 NCAPG NCAPH

Biological processes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.78 BUB1 MELK TP53 TPX2
2 sister chromatid cohesion GO:0007062 9.61 BUB1 CDC20 CDCA8
3 cell division GO:0051301 9.5 BUB1 CCNB2 CDC20 CDCA8 NCAPG NCAPH
4 sterol metabolic process GO:0016125 9.49 CYP11B1 CYP11B2
5 chromosome condensation GO:0030261 9.46 NCAPG NCAPH
6 mitotic chromosome condensation GO:0007076 9.4 NCAPG NCAPH
7 C21-steroid hormone biosynthetic process GO:0006700 9.37 CYP11B1 CYP11B2
8 cellular response to potassium ion GO:0035865 9.32 CYP11B1 CYP11B2
9 cell cycle GO:0007049 9.32 BUB1 CCNB2 CDC20 CDCA8 MCM6 MELK
10 cortisol biosynthetic process GO:0034651 9.26 CYP11B1 CYP11B2
11 aldosterone biosynthetic process GO:0032342 9.16 CYP11B1 CYP11B2

Molecular functions related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclosporin A binding GO:0016018 9.16 PPIG PPP3CA
2 corticosterone 18-monooxygenase activity GO:0047783 8.96 CYP11B1 CYP11B2
3 steroid 11-beta-monooxygenase activity GO:0004507 8.62 CYP11B1 CYP11B2

Sources for Uterine Corpus Endometrial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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