Uterine Corpus Endometrial Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterine Corpus Endometrial Carcinoma

MalaCards integrated aliases for Uterine Corpus Endometrial Carcinoma:

Name: Uterine Corpus Endometrial Carcinoma ¹² ¹⁴

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050939

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Summaries for Uterine Corpus Endometrial Carcinoma

Disease Ontology : ¹² A uterine corpus cancer that is derives from the inner lining of the uterus.

MalaCards based summary : Uterine Corpus Endometrial Carcinoma is related to uterine corpus cancer and familial hyperaldosteronism. An important gene associated with Uterine Corpus Endometrial Carcinoma is NCAPH (Non-SMC Condensin I Complex Subunit H), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cell Cycle Checkpoints. Affiliated tissues include uterus, and related phenotypes are Increased cell death HMECs cells and Increased proliferation

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Related Diseases for Uterine Corpus Endometrial Carcinoma

Diseases related to Uterine Corpus Endometrial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	uterine corpus cancer	10.1	CDCA8 NCAPH TP53
2	familial hyperaldosteronism	10.0	CYP11B1 CYP11B2
3	hyperaldosteronism, familial, type i	9.9	CYP11B1 CYP11B2
4	organ system benign neoplasm	9.9	CYP11B1 CYP11B2 TP53
5	adrenocortical carcinoma, hereditary	9.8	CYP11B1 CYP11B2 TP53

Graphical network of the top 20 diseases related to Uterine Corpus Endometrial Carcinoma:

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Symptoms & Phenotypes for Uterine Corpus Endometrial Carcinoma

GenomeRNAi Phenotypes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	9.35	BUB1 CDC20 MCM6 MELK TP53
2	Increased proliferation	GR00094-A	8.62	BUB1 TP53

MGI Mouse Phenotypes related to Uterine Corpus Endometrial Carcinoma:

⁴³

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.61	CYP11B1 DEGS1 MCM6 NCAPH TP53 TPX2
2	mortality/aging	MP:0010768	9.36	BUB1 CCNB2 CDC20 CDCA8 CYP11B1 DEGS1

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Drugs & Therapeutics for Uterine Corpus Endometrial Carcinoma

Search Clinical Trials , NIH Clinical Center for Uterine Corpus Endometrial Carcinoma

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Genetic Tests for Uterine Corpus Endometrial Carcinoma

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Anatomical Context for Uterine Corpus Endometrial Carcinoma

MalaCards organs/tissues related to Uterine Corpus Endometrial Carcinoma:

³⁸

Uterus

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Publications for Uterine Corpus Endometrial Carcinoma

Articles related to Uterine Corpus Endometrial Carcinoma:

#	Title	Authors	Year
1	Bioinformatics analysis of RNA sequencing data reveals multiple key genes in uterine corpus endometrial carcinoma. ( 29387216 )	Shen L....Li C.	2018
2	Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma. ( 28280730 )	Liu C....Cai Y.D.	2017

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Genes for Uterine Corpus Endometrial Carcinoma

Genes related to Uterine Corpus Endometrial Carcinoma (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication
1	NCAPH	Non-SMC Condensin I Complex Subunit H	Protein Coding	16.74	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
2	CDCA8	Cell Division Cycle Associated 8	Protein Coding	16.4	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
3	MELK	Maternal Embryonic Leucine Zipper Kinase	Protein Coding	15.69	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
4	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	15.42	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
5	TPX2	TPX2, Microtubule Nucleation Factor	Protein Coding	15.34	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
6	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	15.02	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
7	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	14.76	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
8	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	14.46	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
9	PPIG	Peptidylprolyl Isomerase G	Protein Coding	13.93	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
10	TP53	Tumor Protein P53	Protein Coding	13.7	DISEASES inferred ¹⁴ GeneCards inferred via : DISEASES inferred (show sections)
11	BLACAT1	Bladder Cancer Associated Transcript 1 (Non-Protein Coding)	RNA Gene	7.14	DISEASES inferred ¹⁴
12	NCAPG	Non-SMC Condensin I Complex Subunit G	Protein Coding	6.51	DISEASES inferred ¹⁴
13	MCM6	Minichromosome Maintenance Complex Component 6	Protein Coding	5.86	DISEASES inferred ¹⁴
14	CCNB2	Cyclin B2	Protein Coding	5.66	DISEASES inferred ¹⁴
15	CDC20	Cell Division Cycle 20	Protein Coding	5.29	DISEASES inferred ¹⁴
16	DEGS1	Delta 4-Desaturase, Sphingolipid 1	Protein Coding	4.36	DISEASES inferred ¹⁴

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Variations for Uterine Corpus Endometrial Carcinoma

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Expression for Uterine Corpus Endometrial Carcinoma

Search GEO for disease gene expression data for Uterine Corpus Endometrial Carcinoma.

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Pathways for Uterine Corpus Endometrial Carcinoma

Pathways related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Cell Cycle, Mitotic ⁶² Show member pathways Cell Cycle ⁶² M Phase ⁶²	12.97	BUB1 CCNB2 CDC20 CDCA8 MCM6 NCAPG
2	Cell Cycle Checkpoints ⁶² Show member pathways G2/M Checkpoints ⁶²	12.4	CCNB2 CDC20 MCM6 TP53
3	HTLV-I infection ³⁶	12.16	CCNB2 CDC20 PPP3CA TP53
4	Oocyte meiosis ³⁶ Show member pathways Progesterone-mediated oocyte maturation ³⁶	12.08	BUB1 CCNB2 CDC20 PPP3CA
5	Cell cycle ³⁶ ¹	12.01	BUB1 CCNB2 CDC20 MCM6 TP53
6	Mitotic Prometaphase ⁶² Show member pathways Condensation of Prometaphase Chromosomes ⁶² Resolution of Sister Chromatid Cohesion ⁶² RHO GTPases Activate Formins ⁶²	11.97	BUB1 CCNB2 CDC20 CDCA8 NCAPG NCAPH
7	Cellular senescence (KEGG) ³⁶	11.93	CCNB2 PPP3CA TP53
8	Cell cycle_Spindle assembly and chromosome separation ²¹	11.65	CCNB2 CDC20 TPX2
9	Retinoblastoma (RB) in Cancer ¹	11.6	CCNB2 MCM6 TP53
10	Cell cycle_Role of APC in cell cycle regulation ²¹	11.31	BUB1 CCNB2 CDC20
11	PLK1 signaling events ¹ Show member pathways Mitotic Metaphase/Anaphase Transition ⁶² Phosphorylation of Emi1 ⁶²	11.26	BUB1 CDC20 TPX2
12	Aurora A signaling ¹	11.05	TP53 TPX2
13	Cell cycle_Chromosome condensation in prometaphase ²¹	11.02	CCNB2 NCAPG NCAPH
14	superpathway of steroid hormone biosynthesis ¹ Show member pathways androgen biosynthesis ¹ estradiol biosynthesis I ¹ estradiol biosynthesis II ¹	10.88	CYP11B1 CYP11B2
15	DNA Damage Induced 14-3-3Sigma Signaling ⁶⁰	10.79	CCNB2 TP53
16	Aurora B signaling ¹ Show member pathways Aurora C signaling ¹ Signaling by Aurora kinases ¹	10.58	BUB1 CDCA8 NCAPG NCAPH

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GO Terms for Uterine Corpus Endometrial Carcinoma

Cellular components related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.73	BUB1 CCNB2 CDC20 CDCA8 MCM6 MELK
2	chromosome	GO:0005694	9.46	BUB1 CDCA8 NCAPG NCAPH
3	condensin complex	GO:0000796	8.62	NCAPG NCAPH

Biological processes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:0008283	9.78	BUB1 MELK TP53 TPX2
2	sister chromatid cohesion	GO:0007062	9.61	BUB1 CDC20 CDCA8
3	cell division	GO:0051301	9.5	BUB1 CCNB2 CDC20 CDCA8 NCAPG NCAPH
4	sterol metabolic process	GO:0016125	9.49	CYP11B1 CYP11B2
5	chromosome condensation	GO:0030261	9.46	NCAPG NCAPH
6	mitotic chromosome condensation	GO:0007076	9.4	NCAPG NCAPH
7	C21-steroid hormone biosynthetic process	GO:0006700	9.37	CYP11B1 CYP11B2
8	cellular response to potassium ion	GO:0035865	9.32	CYP11B1 CYP11B2
9	cell cycle	GO:0007049	9.32	BUB1 CCNB2 CDC20 CDCA8 MCM6 MELK
10	cortisol biosynthetic process	GO:0034651	9.26	CYP11B1 CYP11B2
11	aldosterone biosynthetic process	GO:0032342	9.16	CYP11B1 CYP11B2

Molecular functions related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cyclosporin A binding	GO:0016018	9.16	PPIG PPP3CA
2	corticosterone 18-monooxygenase activity	GO:0047783	8.96	CYP11B1 CYP11B2
3	steroid 11-beta-monooxygenase activity	GO:0004507	8.62	CYP11B1 CYP11B2

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Sources for Uterine Corpus Endometrial Carcinoma

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⁷² Wikipedia