MCID: UTR038
MIFTS: 40

Uterine Disease malady

Summaries for Uterine Disease

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 The uterus, or womb, is the place where a baby grows when a woman is pregnant. the first sign of a problem with the uterus may be bleeding between periods or after sex. causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. treatment depends on the cause. sometimes birth control pills treat hormonal imbalances. if a thyroid problem is the cause, treating it may also stop the bleeding. if you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. with two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. in endometriosis, it grows outside the uterus. in adenomyosis, it grows in the uterus's outside walls. pain medicine may help. other treatments include hormones and surgery.

MalaCards: Uterine Disease, also known as uterine diseases, is related to vaginal disease and uterine inflammatory disease. An important gene associated with Uterine Disease is ESR1 (estrogen receptor 1), and among its related pathways are Integrated Breast Cancer Pathway and Estrogen biosynthesis. The drug carboxymethylcellulose calcium and the compounds Chlorotrianisene and nolvadex have been mentioned in the context of this disorder. Affiliated tissues include the uterus, lung and uterus, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A female reproductive system disease that is located in the uterus.

Wikipedia:64 The uterus (from Latin \"uterus\", plural uteri) or womb is a major female hormone-responsive... more...

Aliases & Classifications for Uterine Disease

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

uterine disease 8
uterine diseases 45 34 61
uterine abnormality 45


External Ids:

Disease Ontology8 DOID:345
NCIt40 C26907
ICD9CM27 621.9
MeSH35 D014591

Related Diseases for Uterine Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Uterine Disease family:

uterine inflammatory disease

Diseases related to Uterine Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1vaginal disease10.2
2uterine inflammatory disease10.0
3adenomyosis10.0
4aromatase deficiency10.0CYP19A1
5uterine fibroid10.0ESR1
6breast fibroadenoma10.0ESR1
7leydig cell tumor10.0CYP19A1
8cryptorchidism10.0CYP19A1
9ductal carcinoma in situ10.0ESR1
10insulin resistance10.0IGFBP1
11cervical cancer10.0IGFBP1
12growth hormone deficiency10.0IGFBP1
13diabetes mellitus10.0IGFBP1
14adenoma10.0IGFBP1
15endometrial stromal sarcoma10.0ESR1, CYP19A1
16leiomyoma10.0ESR1, CYP19A1
17abrikosov's tumor10.0CYP19A1, ESR1
18osteoporosis, postmenopausal10.0ESR1, CYP19A1
19li-fraumeni syndrome10.0CYP19A1, ESR1
20uterine sarcoma10.0ESR1, CYP19A1
21factor vii deficiency10.0CYP19A1, ESR1
22hypogonadism10.0CYP19A1
23myoma10.0CYP19A1, ESR1
24gynecomastia10.0CYP19A1, ESR1
25obesity10.0IGFBP1
26ovarian disease10.0IGFBP1, CYP19A1
27anovulation10.0CYP19A1, IGFBP1
28polycystic ovary syndrome10.0IGFBP1, CYP19A1
29osteoporosis10.0ESR1, CYP19A1
30hyperandrogenism10.0CYP19A1, IGFBP1
31breast cancer10.0CYP19A1, ESR1
32short stature10.0CYP19A1, IGFBP1
33endometrial carcinoma10.0ESR1, IGFBP1, CYP19A1
34endometriosis10.0IGFBP1, ESR1, CYP19A1
35infertility10.0ESR1, CYP19A1, IGFBP1
36sciatic neuropathy9.9
37papillary carcinoma9.9
38placenta accreta9.9
39syphilis9.9
40uterine corpus cancer9.9
41colorectal cancer9.9
42devic disease9.9
43myelomeningocele9.9
44m�ni�re disease9.9

Graphical network of the top 20 diseases related to Uterine Disease:



Diseases related to uterine disease

Clinical Features for Uterine Disease

Drugs & Therapeutics for Uterine Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uterine Disease

Drug clinical trials:

Search ClinicalTrials for Uterine Disease

Search NIH Clinical Center for Uterine Disease

Search CenterWatch for Uterine Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Uterine Disease

Anatomical Context for Uterine Disease

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Uterine Disease:

33
Lung, Uterus, Heart, Small intestine, Thyroid, Breast, Placenta, Prostate, Cervix, Myeloid, Monocytes, Uterus corpus

FMA organs/tissues related to Uterine Disease:

14
The uterus

Animal Models for Uterine Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Uterine Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, CYP19A1, IGFBP1

Publications for Uterine Disease

Sources:
51PubMed
See all sources

Articles related to Uterine Disease:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. (24209779)
2013
2
The effect of puerperal uterine disease on uterine involution in cows assessed by Doppler sonography of the uterine arteries. (24275717)
2013
3
The influence of primary site on outcomes in leiomyosarcoma: a review of clinicopathologic differences between uterine and extrauterine disease. (22772425)
2013
4
Neuroendocrine carcinoma of the uterine cervix: the role of multimodality therapy in early-stage disease. (23357610)
2013
5
Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. (22284667)
2012
6
Evaluation of cytokine expression by blood monocytes of lactating Holstein cows with or without postpartum uterine disease. (21924475)
2012
7
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. (22865295)
2012
8
When do we need to perform laparotomy for benign uterine disease? Factors involved with conversion in vaginal hysterectomy. (21955358)
2012
9
Krukenberg tumour simulating uterine fibroids and pelvic inflammatory disease. (20857797)
2010
10
Unusual Osteoblastic Secondary Lesion as Predominant Metastatic Disease Spread in Two Cases of Uterine Leiomyosarcoma. (20740159)
2010
11
A prospective randomized comparison of vaginal hysterectomy, laparoscopically assisted vaginal hysterectomy, and total laparoscopic hysterectomy in women with benign uterine disease. (19926201)
2010
12
Risk assessment of postpartum uterine disease and consequences of puerperal metritis for subsequent metabolic status, reproduction and milk yield in dairy cows. (19457784)
2009
13
Bleeding management of uterine conization using a pasteurized FVIII/VWF Concentrate in a woman affected by type 2A von willebrand disease. (18160560)
2009
14
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. (19439667)
2009
15
The value of minilaparotomy for total hysterectomy for benign uterine disease: a comparative study with conventional Pfannenstiel and laparoscopic approaches. (19386113)
2009
16
Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. (18470523)
2009
17
Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease. (18980243)
2009
18
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. (18577555)
2008
19
Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk. (18691687)
2008
20
Defining postpartum uterine disease in cattle. (16226305)
2006
21
MR imaging of malignant uterine disease. (17433977)
2006
22
Small bowel obstruction due to adhesive disease observed after uterine fibroid embolization. (16150299)
2005
23
The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. (15581942)
2004
24
von Willebrand's disease: an important cause of dysfunctional uterine bleeding. (11914650)
2002
25
Early uterine serous carcinoma: clonal origin of extrauterine disease. (11444195)
2001
26
Oncoprotein c-erbB-2 in squamous cell carcinoma of the uterine cervix and evaluation of its significance in response of disease to treatment. (11480225)
2001
27
Cold agglutinin disease in a patient with uterine sarcoma. (11093691)
2000
28
Is uterine serous papillary carcinoma a BRCA1-related disease? Case report and review of the literature. (10525392)
1999
29
ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. (9765232)
1998
30
Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. (9358772)
1997
31
Ovarian and uterine disease in women with colorectal cancer. (8990444)
1997
32
Vaginal hysterectomy for benign uterine disease in the laparoscopically confirmed frozen pelvis. (9449083)
1997
33
Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection. (8677789)
1996
34
Investigating uterine disease in the bitch: uterine cannulation for cytology, microbiology and hysteroscopy. (7650914)
1995
35
Adenomyosis--an ignored uterine disease. (7501319)
1995
36
Uterine atypical polypoid adenomyoma and ovarian endometrioid carcinoma: metastatic disease or dual primaries? (7883432)
1995
37
Prophylactic oophorectomy of benign uterine disease in premenopausal women: 11 years review. (7745370)
1994
38
Insulin-like growth factors and their binding proteins in benign and malignant uterine diseases. (7683538)
1993
39
Bovine uterine, cervical and ovarian cytosol estrogen and progesterone receptor concentrations in cystic ovarian disease. (8342463)
1993
40
Dysfunctional uterine bleeding associated with 45X/47XXX mosaicism and Von Willebrand's disease. (3542918)
1986
41
Increased risk of malignancy and uterine disease following perimenarchal hospitalization: an estrogen window effect. (6623355)
1983
42
Effects of reserpine administration on rat mammary tumors and uterine disease induced by N-nitrosomethylurea. (6307707)
1983
43
Estimates of the true population at risk of uterine disease and an application to incidence data for cancer of the uterine corpus in Connecticut. (7377178)
1980
44
Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. (377970)
1979
45
Myelomeningocele: a progressive intra-uterine disease. (797606)
1976
46
Uterine myoma as a hereditary disease. (13386269)
1957
47
The frequency of hysterectomy for benign uterine disease. (18868374)
1948
48
Radiotherapy for benign uterine disease. (20269642)
1947
49
MENORRHAGIAS NOT DUE TO UTERINE DISEASE: CAUSATION, CLINICAL FEATURES, AND TREATMENT. (20776403)
1931
50
On Dilatation of the Uterus, and the Treatment of some of the Commoner Forms of Uterine Disease. (20753787)
1892

Genetic Variations for Uterine Disease

Expression for genes affiliated with Uterine Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uterine Disease

Search GEO for disease gene expression data for Uterine Disease.

Pathways for genes affiliated with Uterine Disease

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB
See all sources

Pathways related to Uterine Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ESR1, CYP19A1
2
Hide members
9.3ESR1, CYP19A1

Compounds for genes affiliated with Uterine Disease

Sources:
11DrugBank, 45Novoseek, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Uterine Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1Chlorotrianisene119.8ESR1, CYP19A1
2nolvadex459.8CYP19A1, ESR1
3idoxifene459.8CYP19A1, ESR1
4vinclozolin459.8ESR1, CYP19A1
5ment459.8CYP19A1, ESR1
6formestane459.8CYP19A1, ESR1
7fadrozole459.7ESR1, CYP19A1
8clomifene50 1110.7CYP19A1, ESR1
9ibandronate45 1110.7ESR1, CYP19A1
10nandrolone45 2410.7CYP19A1, ESR1
11estradiol benzoate459.7ESR1, CYP19A1
12goserelin45 29 1111.7ESR1, CYP19A1
13aminoglutethimide45 1110.7ESR1, CYP19A1
14megestrol acetate459.7ESR1, CYP19A1
155alpha-androstane-3alpha,17beta-diol459.7CYP19A1, ESR1
16leuprolide acetate459.7CYP19A1, ESR1
17risedronate45 60 50 29 1113.7ESR1, CYP19A1
18exemestane50 45 60 1112.7CYP19A1, ESR1
19bisphenol a459.7CYP19A1, ESR1
20lapatinib45 50 1111.6CYP19A1, ESR1
21toremifene45 1110.6ESR1, CYP19A1
22naringenin45 1110.6CYP19A1, ESR1
23tibolone459.6CYP19A1, ESR1
24fulvestrant45 50 29 1112.6ESR1, CYP19A1
25danazol45 11 2411.6CYP19A1, ESR1
26taxane459.5ESR1, CYP19A1
27letrozole45 50 60 1112.5ESR1, CYP19A1
28buserelin45 29 1111.5IGFBP1, CYP19A1
29flutamide45 60 1111.4CYP19A1, ESR1
30droloxifene459.4IGFBP1, ESR1
31bicalutamide45 60 1111.4ESR1, CYP19A1
32isoflavone459.4IGFBP1, ESR1
33steroidal459.3ESR1, CYP19A1
34indole-3-carbinol459.3ESR1, CYP19A1
3517-hydroxyprogesterone45 2410.3CYP19A1, IGFBP1
36estrone sulfate45 2410.2ESR1, CYP19A1
37anastrozole45 1110.0CYP19A1, ESR1, IGFBP1
38clomiphene citrate459.0CYP19A1, ESR1, IGFBP1
39levonorgestrel45 60 29 1112.0IGFBP1, CYP19A1, ESR1
40progestins459.0IGFBP1, CYP19A1, ESR1
41progestin458.9CYP19A1, ESR1, IGFBP1
42mifepristone45 60 29 1111.9IGFBP1, ESR1, CYP19A1
43estrone45 29 11 2411.9CYP19A1, IGFBP1, ESR1
44dihydrotestosterone45 29 11 2411.9IGFBP1, CYP19A1, ESR1
45gnrh458.9CYP19A1, ESR1, IGFBP1
46tamoxifen45 50 29 1111.9ESR1, IGFBP1, CYP19A1
47vitamin d458.9ESR1, CYP19A1, IGFBP1
48estradiol45 11 2410.8IGFBP1, CYP19A1, ESR1
49genistein45 29 60 2 11 2413.8IGFBP1, CYP19A1, ESR1
50cycloheximide458.2CYP19A1, ESR1, IGFBP1

GO Terms for genes affiliated with Uterine Disease

Sources:
16Gene Ontology
See all sources

Biological processes related to Uterine Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.3ESR1, CYP19A1

Products for genes affiliated with Uterine Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet