Aliases & Classifications for Uterine Disease

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Uterine Disease, Aliases & Descriptions:

Name: Uterine Disease 9
Uterine Diseases 43 32 60
 
Uterine Abnormality 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:345
NCIt38 C26907
ICD9CM27 621.9
MeSH33 D014591

Summaries for Uterine Disease

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MedlinePlus:32 The uterus, or womb, is the place where a baby grows when a woman is pregnant. the first sign of a problem with the uterus may be bleeding between periods or after sex. causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. treatment depends on the cause. sometimes birth control pills treat hormonal imbalances. if a thyroid problem is the cause, treating it may also stop the bleeding. if you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. with two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. in endometriosis, it grows outside the uterus. in adenomyosis, it grows in the uterus's outside walls. pain medicine may help. other treatments include hormones and surgery.

MalaCards based summary: Uterine Disease, also known as uterine diseases, is related to endometrial cancer and breast fibroadenoma, and has symptoms including autosomal dominant inheritanceand bicornuate uterus. An important gene associated with Uterine Disease is IGFBP1 (insulin-like growth factor binding protein 1), and among its related pathways are Integrated Breast Cancer Pathway and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. The drug carboxymethylcellulose calcium and the compounds droloxifene and isoflavone have been mentioned in the context of this disorder. Affiliated tissues include the uterus, uterus and thyroid, and related mouse phenotypes are cellular and liver/biliary system.

Disease Ontology:9 A female reproductive system disease that is located in the uterus.

Related Diseases for Uterine Disease

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Graphical network of the top 20 diseases related to Uterine Disease:



Diseases related to uterine disease

Symptoms for Uterine Disease

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HPO human phenotypes related to Uterine Disease:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 bicornuate uterus HP:0000813

Drugs & Therapeutics for Uterine Disease

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Drug clinical trials:

Search ClinicalTrials for Uterine Disease

Search NIH Clinical Center for Uterine Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Uterine Disease

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Anatomical Context for Uterine Disease

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MalaCards organs/tissues related to Uterine Disease:

31
Uterus, Thyroid, Neutrophil, Breast, Placenta, Monocytes

FMA organs/tissues related to Uterine Disease:

14
The uterus

Animal Models for Uterine Disease or affiliated genes

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MGI Mouse Phenotypes related to Uterine Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.5ESR1, CYP19A1, IGFBP1
2MP:00053708.4ESR1, CYP19A1, IGFBP1
3MP:00053878.2ESR1, CYP19A1, IGFBP1

Publications for Uterine Disease

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Articles related to Uterine Disease:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
MRI appearances of benign uterine disease. (25017452)
2014
2
Laparoendoscopic single-site versus conventional laparoscopic-assisted vaginal hysterectomy for benign or pre-invasive uterine disease. (25106721)
2014
3
Differential endometrial cell sensitivity to a cholesterol-dependent cytolysin links Trueperella pyogenes to uterine disease in cattle. (24478394)
2014
4
Mucin 1 and cytokines mRNA in endometrium of dairy cows with postpartum uterine disease or repeat breeding. (24576715)
2014
5
Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. (24209779)
2013
6
The effect of puerperal uterine disease on uterine involution in cows assessed by Doppler sonography of the uterine arteries. (24275717)
2013
7
Drivers of post-partum uterine disease in dairy cattle. (23962215)
2013
8
The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. (21918977)
2012
9
Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. (22284667)
2012
10
Evaluation of cytokine expression by blood monocytes of lactating Holstein cows with or without postpartum uterine disease. (21924475)
2012
11
Tackling uterine disease in cattle. (22544588)
2012
12
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. (22865295)
2012
13
Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. (23021755)
2012
14
AAGL position statement: route of hysterectomy to treat benign uterine disease. (21059487)
2011
15
A prospective randomized comparison of vaginal hysterectomy, laparoscopically assisted vaginal hysterectomy, and total laparoscopic hysterectomy in women with benign uterine disease. (19926201)
2010
16
Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows. (20630210)
2010
17
Risk assessment of postpartum uterine disease and consequences of puerperal metritis for subsequent metabolic status, reproduction and milk yield in dairy cows. (19457784)
2009
18
The value of minilaparotomy for total hysterectomy for benign uterine disease: a comparative study with conventional Pfannenstiel and laparoscopic approaches. (19386113)
2009
19
Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. (19439727)
2009
20
Plasma PGF 2 alpha metabolite levels in cats with uterine disease. (19748114)
2009
21
Postpartum uterine disease and dairy herd reproductive performance: a review. (18328749)
2008
22
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. (18577555)
2008
23
When is laparotomy needed in hysterectomy for benign uterine disease? (18262142)
2008
24
MR imaging of benign uterine disease. (17433976)
2006
25
Defining postpartum uterine disease in cattle. (16226305)
2006
26
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. (16109840)
2005
27
Combination of a tension-free vaginal tape procedure and laparoscopic-assisted vaginal hysterectomy for the treatment of benign uterine disease associated with stress urinary incontinence. (15945323)
2005
28
Evaluation of a device for objective determination of cervical consistency: a pilot study of device's validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease. (12442598)
2002
29
Ovarian and uterine disease in women with colorectal cancer. (8990444)
1997
30
Vaginal hysterectomy for benign uterine disease in the laparoscopically confirmed frozen pelvis. (9449083)
1997
31
The place of hysterectomy in the management of benign uterine disease. (10158543)
1996
32
Investigating uterine disease in the bitch: uterine cannulation for cytology, microbiology and hysteroscopy. (7650914)
1995
33
Adenomyosis--an ignored uterine disease. (7501319)
1995
34
Adenomyosis--an ignored uterine disease. (7596529)
1995
35
Prophylactic oophorectomy of benign uterine disease in premenopausal women: 11 years review. (7745370)
1994
36
Insulin-like growth factors and their binding proteins in benign and malignant uterine diseases. (7683538)
1993
37
Histopathologic features, environmental factors, and serum estrogen, progesterone, and prolactin values associated with ovarian phase and inflammatory uterine disease in cats. (1768001)
1991
38
Increased risk of malignancy and uterine disease following perimenarchal hospitalization: an estrogen window effect. (6623355)
1983
39
Effects of reserpine administration on rat mammary tumors and uterine disease induced by N-nitrosomethylurea. (6307707)
1983
40
Estimates of the true population at risk of uterine disease and an application to incidence data for cancer of the uterine corpus in Connecticut. (7377178)
1980
41
Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. (377970)
1979
42
Myelomeningocele: a progressive intra-uterine disease. (797606)
1976
43
Plasma progesterone levels in canine uterine disease. (5064888)
1972
44
Surgical correction of contributory causes of uterine disease in the mare. (5749685)
1968
45
The frequency of hysterectomy for benign uterine disease. (18868374)
1948
46
Radiotherapy for benign uterine disease. (20269642)
1947
47
Syphilis in Relation to Uterine Disease. (19977994)
1914
48
On Dilatation of the Uterus, and the Treatment of some of the Commoner Forms of Uterine Disease. (20753787)
1892
49
The Treatment of Intra-Uterine Disease. (20751080)
1884
50
On the Treatment of Intra-Uterine Disease: With Special Reference to the Best Mode of Making Applications to the Intra-Uterine Surface. (20751078)
1884

Variations for Uterine Disease

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Expression for genes affiliated with Uterine Disease

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Search GEO for disease gene expression data for Uterine Disease.

Pathways for genes affiliated with Uterine Disease

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Pathways related to Uterine Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ESR1, CYP19A1
2
Show member pathways
9.1ESR1, CYP19A1

Compounds for genes affiliated with Uterine Disease

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Compounds related to Uterine Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1droloxifene439.7IGFBP1, ESR1
2isoflavone439.7ESR1, IGFBP1
3nolvadex439.6ESR1, CYP19A1
4idoxifene439.6CYP19A1, ESR1
5vinclozolin439.6CYP19A1, ESR1
6ment439.6ESR1, CYP19A1
7formestane439.6ESR1, CYP19A1
8fadrozole439.5ESR1, CYP19A1
9ibandronate43 1210.5ESR1, CYP19A1
10clomifene49 1210.5ESR1, CYP19A1
11estradiol benzoate439.5CYP19A1, ESR1
12nandrolone43 2410.5CYP19A1, ESR1
13goserelin43 28 1211.5ESR1, CYP19A1
14aminoglutethimide43 1210.5CYP19A1, ESR1
155alpha-androstane-3alpha,17beta-diol439.5ESR1, CYP19A1
16megestrol acetate439.5ESR1, CYP19A1
17leuprolide acetate439.5CYP19A1, ESR1
18risedronate43 49 28 59 1213.5ESR1, CYP19A1
19exemestane43 49 59 1212.5ESR1, CYP19A1
20bisphenol a439.4CYP19A1, ESR1
21lapatinib43 49 1211.4ESR1, CYP19A1
22naringenin43 1210.4ESR1, CYP19A1
23vitamin d439.4CYP19A1, IGFBP1
24toremifene43 1210.4ESR1, CYP19A1
25tibolone439.4CYP19A1, ESR1
26buserelin43 28 1211.4IGFBP1, CYP19A1
27fulvestrant43 49 28 1212.4ESR1, CYP19A1
28danazol43 24 1211.4ESR1, CYP19A1
29taxane439.4CYP19A1, ESR1
30letrozole43 49 59 1212.3CYP19A1, ESR1
31flutamide43 59 1211.2CYP19A1, ESR1
3217-hydroxyprogesterone43 2410.2CYP19A1, IGFBP1
33estrone sulfate43 2410.2CYP19A1, ESR1
34steroidal439.1CYP19A1, ESR1
35bicalutamide43 59 1211.0CYP19A1, ESR1
36anastrozole43 49 1211.0ESR1, CYP19A1, IGFBP1
37clomiphene citrate439.0ESR1, CYP19A1, IGFBP1
38levonorgestrel43 59 28 1212.0IGFBP1, CYP19A1, ESR1
39progestins439.0ESR1, CYP19A1, IGFBP1
40progestin438.9IGFBP1, CYP19A1, ESR1
41mifepristone43 28 59 1211.9ESR1, CYP19A1, IGFBP1
42estrone43 28 24 1211.9ESR1, CYP19A1, IGFBP1
43dihydrotestosterone43 28 24 1211.9IGFBP1, CYP19A1, ESR1
44gnrh438.9IGFBP1, CYP19A1, ESR1
45tamoxifen43 49 28 1211.9IGFBP1, CYP19A1, ESR1
46estradiol43 24 1210.8IGFBP1, CYP19A1, ESR1
47genistein43 28 59 2 24 1213.8ESR1, CYP19A1, IGFBP1
48cycloheximide438.7ESR1, CYP19A1, IGFBP1
49testosterone43 59 24 1211.5ESR1, CYP19A1, IGFBP1
50progesterone43 28 59 24 1212.2ESR1, CYP19A1, IGFBP1

GO Terms for genes affiliated with Uterine Disease

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Biological processes related to Uterine Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00082099.1ESR1, CYP19A1

Products for genes affiliated with Uterine Disease

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  • Antibodies
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  • Kits and Assays

Sources for Uterine Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet