MCID: UTR038
MIFTS: 45

Uterine Disease malady

Reproductive diseases category

Summaries for Uterine Disease

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 The uterus, or womb, is the place where a baby grows when a woman is pregnant. the first sign of a problem with the uterus may be bleeding between periods or after sex. causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. treatment depends on the cause. sometimes birth control pills treat hormonal imbalances. if a thyroid problem is the cause, treating it may also stop the bleeding. if you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. with two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. in endometriosis, it grows outside the uterus. in adenomyosis, it grows in the uterus's outside walls. pain medicine may help. other treatments include hormones and surgery.

MalaCards: Uterine Disease, also known as uterine diseases, is related to vaginitis and breast fibroadenoma. An important gene associated with Uterine Disease is IGFBP1 (insulin-like growth factor binding protein 1), and among its related pathways are Integrated Breast Cancer Pathway and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. The drug carboxymethylcellulose calcium and the compounds droloxifene and isoflavone have been mentioned in the context of this disorder. Affiliated tissues include the uterus, uterus and thyroid, and related mouse phenotypes are cellular and liver/biliary system.

Disease Ontology:9 A female reproductive system disease that is located in the uterus.

Wikipedia:66 The uterus (from Latin \"uterus\", plural uteri) or womb is a major female hormone-responsive... more...

Aliases & Classifications for Uterine Disease

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Sources:
9Disease Ontology, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

uterine disease 9
uterine diseases 46 35 63
uterine abnormality 46


External Ids:

Disease Ontology9 DOID:345
ICD9CM28 621.9
NCIt41 C26907
MeSH36 D014591

Related Diseases for Uterine Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Uterine Disease:



Diseases related to uterine disease

Symptoms for Uterine Disease

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Drugs & Therapeutics for Uterine Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Uterine Disease

Drug clinical trials:

Search ClinicalTrials for Uterine Disease

Search NIH Clinical Center for Uterine Disease

Search CenterWatch for Uterine Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Uterine Disease

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Anatomical Context for Uterine Disease

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Uterine Disease:

34
Uterus, Thyroid, Cervix, Breast, Placenta, Monocytes

FMA organs/tissues related to Uterine Disease:

15
The uterus

Animal Models for Uterine Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Uterine Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.5ESR1, CYP19A1, IGFBP1
2MP:00053708.4ESR1, CYP19A1, IGFBP1
3MP:00053878.2ESR1, CYP19A1, IGFBP1

Publications for Uterine Disease

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Sources:
53PubMed
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Articles related to Uterine Disease:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. (24209779)
2013
2
The effect of puerperal uterine disease on uterine involution in cows assessed by Doppler sonography of the uterine arteries. (24275717)
2013
3
Drivers of post-partum uterine disease in dairy cattle. (23962215)
2013
4
The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. (21918977)
2012
5
Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. (22284667)
2012
6
Evaluation of cytokine expression by blood monocytes of lactating Holstein cows with or without postpartum uterine disease. (21924475)
2012
7
Tackling uterine disease in cattle. (22544588)
2012
8
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. (22865295)
2012
9
Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. (23021755)
2012
10
When do we need to perform laparotomy for benign uterine disease? Factors involved with conversion in vaginal hysterectomy. (21955358)
2012
11
AAGL position statement: route of hysterectomy to treat benign uterine disease. (21059487)
2011
12
A prospective randomized comparison of vaginal hysterectomy, laparoscopically assisted vaginal hysterectomy, and total laparoscopic hysterectomy in women with benign uterine disease. (19926201)
2010
13
Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows. (20630210)
2010
14
Risk assessment of postpartum uterine disease and consequences of puerperal metritis for subsequent metabolic status, reproduction and milk yield in dairy cows. (19457784)
2009
15
The value of minilaparotomy for total hysterectomy for benign uterine disease: a comparative study with conventional Pfannenstiel and laparoscopic approaches. (19386113)
2009
16
Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. (19439727)
2009
17
Plasma PGF 2 alpha metabolite levels in cats with uterine disease. (19748114)
2009
18
Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. (19476661)
2009
19
Postpartum uterine disease and dairy herd reproductive performance: a review. (18328749)
2008
20
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. (18577555)
2008
21
When is laparotomy needed in hysterectomy for benign uterine disease? (18262142)
2008
22
MR imaging of benign uterine disease. (17433976)
2006
23
Defining postpartum uterine disease in cattle. (16226305)
2006
24
MR imaging of malignant uterine disease. (17433977)
2006
25
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. (16109840)
2005
26
Combination of a tension-free vaginal tape procedure and laparoscopic-assisted vaginal hysterectomy for the treatment of benign uterine disease associated with stress urinary incontinence. (15945323)
2005
27
Evaluation of a device for objective determination of cervical consistency: a pilot study of device's validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease. (12442598)
2002
28
Ovarian and uterine disease in women with colorectal cancer. (8990444)
1997
29
Vaginal hysterectomy for benign uterine disease in the laparoscopically confirmed frozen pelvis. (9449083)
1997
30
The place of hysterectomy in the management of benign uterine disease. (10158543)
1996
31
Investigating uterine disease in the bitch: uterine cannulation for cytology, microbiology and hysteroscopy. (7650914)
1995
32
Adenomyosis--an ignored uterine disease. (7501319)
1995
33
Adenomyosis--an ignored uterine disease. (7596529)
1995
34
Prophylactic oophorectomy of benign uterine disease in premenopausal women: 11 years review. (7745370)
1994
35
Insulin-like growth factors and their binding proteins in benign and malignant uterine diseases. (7683538)
1993
36
Histopathologic features, environmental factors, and serum estrogen, progesterone, and prolactin values associated with ovarian phase and inflammatory uterine disease in cats. (1768001)
1991
37
Increased risk of malignancy and uterine disease following perimenarchal hospitalization: an estrogen window effect. (6623355)
1983
38
Effects of reserpine administration on rat mammary tumors and uterine disease induced by N-nitrosomethylurea. (6307707)
1983
39
Estimates of the true population at risk of uterine disease and an application to incidence data for cancer of the uterine corpus in Connecticut. (7377178)
1980
40
Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. (377970)
1979
41
Myelomeningocele: a progressive intra-uterine disease. (797606)
1976
42
Plasma progesterone levels in canine uterine disease. (5064888)
1972
43
Surgical correction of contributory causes of uterine disease in the mare. (5749685)
1968
44
The frequency of hysterectomy for benign uterine disease. (18868374)
1948
45
Radiotherapy for benign uterine disease. (20269642)
1947
46
MENORRHAGIAS NOT DUE TO UTERINE DISEASE: CAUSATION, CLINICAL FEATURES, AND TREATMENT. (20776403)
1931
47
Syphilis in Relation to Uterine Disease. (19977994)
1914
48
On Dilatation of the Uterus, and the Treatment of some of the Commoner Forms of Uterine Disease. (20753787)
1892
49
The Treatment of Intra-Uterine Disease. (20751080)
1884
50
On the Treatment of Intra-Uterine Disease: With Special Reference to the Best Mode of Making Applications to the Intra-Uterine Surface. (20751078)
1884

Variations for Uterine Disease

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Expression for genes affiliated with Uterine Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uterine Disease

Search GEO for disease gene expression data for Uterine Disease.

Pathways for genes affiliated with Uterine Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome
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Pathways related to Uterine Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ESR1, CYP19A1
2
Show member pathways
9.1ESR1, CYP19A1

Compounds for genes affiliated with Uterine Disease

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Uterine Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1droloxifene469.7IGFBP1, ESR1
2isoflavone469.7IGFBP1, ESR1
3nolvadex469.6ESR1, CYP19A1
4vinclozolin469.6CYP19A1, ESR1
5idoxifene469.6CYP19A1, ESR1
6formestane469.6CYP19A1, ESR1
7ment469.6CYP19A1, ESR1
8fadrozole469.5CYP19A1, ESR1
9clomifene52 1210.5ESR1, CYP19A1
10ibandronate46 1210.5CYP19A1, ESR1
11estradiol benzoate469.5ESR1, CYP19A1
12nandrolone46 2510.5CYP19A1, ESR1
13goserelin46 30 1211.5ESR1, CYP19A1
14aminoglutethimide46 1210.5CYP19A1, ESR1
155alpha-androstane-3alpha,17beta-diol469.5ESR1, CYP19A1
16megestrol acetate469.5ESR1, CYP19A1
17leuprolide acetate469.5ESR1, CYP19A1
18risedronate46 52 30 62 1213.5CYP19A1, ESR1
19exemestane46 52 62 1212.5CYP19A1, ESR1
20bisphenol a469.4CYP19A1, ESR1
21lapatinib46 52 1211.4ESR1, CYP19A1
22toremifene46 1210.4CYP19A1, ESR1
23vitamin d469.4CYP19A1, IGFBP1
24naringenin46 1210.4CYP19A1, ESR1
25tibolone469.4ESR1, CYP19A1
26buserelin46 30 1211.4CYP19A1, IGFBP1
27danazol46 25 1211.4ESR1, CYP19A1
28fulvestrant46 52 30 1212.4CYP19A1, ESR1
29letrozole46 52 62 1212.4CYP19A1, ESR1
30taxane469.3CYP19A1, ESR1
31flutamide46 62 1211.2ESR1, CYP19A1
3217-hydroxyprogesterone46 2510.2IGFBP1, CYP19A1
33bicalutamide46 62 1211.2CYP19A1, ESR1
34steroidal469.1ESR1, CYP19A1
35estrone sulfate46 2510.0CYP19A1, ESR1
36anastrozole46 52 1211.0ESR1, CYP19A1, IGFBP1
37clomiphene citrate469.0IGFBP1, CYP19A1, ESR1
38levonorgestrel46 62 30 1212.0IGFBP1, CYP19A1, ESR1
39progestins469.0ESR1, IGFBP1, CYP19A1
40progestin468.9ESR1, IGFBP1, CYP19A1
41mifepristone46 30 62 1211.9IGFBP1, CYP19A1, ESR1
42estrone46 30 25 1211.9IGFBP1, CYP19A1, ESR1
43dihydrotestosterone46 30 25 1211.9IGFBP1, ESR1, CYP19A1
44gnrh468.9ESR1, IGFBP1, CYP19A1
45tamoxifen46 52 30 1211.9ESR1, CYP19A1, IGFBP1
46estradiol46 25 1210.8IGFBP1, CYP19A1, ESR1
47genistein46 30 62 3 25 1213.8CYP19A1, ESR1, IGFBP1
48cycloheximide468.7IGFBP1, ESR1, CYP19A1
49testosterone46 62 25 1211.5ESR1, IGFBP1, CYP19A1
50progesterone46 30 62 25 1212.2IGFBP1, ESR1, CYP19A1

GO Terms for genes affiliated with Uterine Disease

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Sources:
17Gene Ontology
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Biological processes related to Uterine Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.1ESR1, CYP19A1

Products for genes affiliated with Uterine Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet