MCID: UTR038
MIFTS: 42

Uterine Disease malady

Summaries for Uterine Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The uterus, or womb, is the place where a baby grows when a woman is pregnant. the first sign of a problem with the uterus may be bleeding between periods or after sex. causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. treatment depends on the cause. sometimes birth control pills treat hormonal imbalances. if a thyroid problem is the cause, treating it may also stop the bleeding. if you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. with two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. in endometriosis, it grows outside the uterus. in adenomyosis, it grows in the uterus's outside walls. pain medicine may help. other treatments include hormones and surgery.

MalaCards: Uterine Disease, also known as uterine diseases, is related to ovarian disease and vaginal disease. An important gene associated with Uterine Disease is ESR1 (estrogen receptor 1), and among its related pathways are Integrated Breast Cancer Pathway and Estrogen biosynthesis. The drug carboxymethylcellulose calcium and the compounds Chlorotrianisene and nolvadex have been mentioned in the context of this disorder. Affiliated tissues include the uterus, uterus and cervix, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A female reproductive system disease that is located in the uterus.

Wikipedia:63 The uterus (from Latin \"uterus\", plural uteri) or womb is a major female hormone-responsive... more...

Aliases & Classifications for Uterine Disease

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

uterine disease 8
uterine diseases 44 33 60
uterine abnormality 44


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Disease Ontology8 DOID:345
NCIt39 C26907
ICD9CM27 621.9
MeSH34 D014591

Related Diseases for Uterine Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Uterine Disease family:

Uterine Inflammatory Disease

Diseases related to Uterine Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian disease30.0IGFBP1, CYP19A1
2vaginal disease10.2
3vaginitis10.2
4uterine inflammatory disease10.0
5placenta disease10.0
6aromatase deficiency10.0CYP19A1
7uterine fibroid10.0ESR1
8breast fibroadenoma10.0ESR1
9leydig cell tumor10.0CYP19A1
10cryptorchidism10.0CYP19A1
11ductal carcinoma in situ10.0ESR1
12insulin resistance10.0IGFBP1
13cervical cancer10.0IGFBP1
14growth hormone deficiency10.0IGFBP1
15diabetes mellitus10.0IGFBP1
16adenoma10.0IGFBP1
17endocrine gland cancer10.0ESR1, CYP19A1
18endometrial stromal sarcoma10.0ESR1, CYP19A1
19leiomyoma10.0ESR1, CYP19A1
20abrikosov's tumor10.0ESR1, CYP19A1
21li-fraumeni syndrome10.0CYP19A1, ESR1
22osteoporosis, postmenopausal10.0CYP19A1, ESR1
23uterine sarcoma10.0ESR1, CYP19A1
24factor vii deficiency10.0ESR1, CYP19A1
25hypogonadism10.0CYP19A1
26myoma10.0ESR1, CYP19A1
27gynecomastia10.0CYP19A1, ESR1
28obesity10.0IGFBP1
29anovulation10.0IGFBP1, CYP19A1
30polycystic ovary syndrome10.0IGFBP1, CYP19A1
31osteoporosis10.0CYP19A1, ESR1
32hyperandrogenism10.0IGFBP1, CYP19A1
33breast cancer10.0CYP19A1, ESR1
34short stature10.0CYP19A1, IGFBP1
35endometrial carcinoma10.0ESR1, CYP19A1, IGFBP1
36endometriosis10.0ESR1, CYP19A1, IGFBP1
37infertility10.0IGFBP1, CYP19A1, ESR1
38sciatic neuropathy9.9
39neuropathy9.9
40papillary carcinoma9.9
41placenta accreta9.9
42breast disease9.9
43cervicitis9.9
44ovarian cancer9.9
45syphilis9.9
46uterine corpus cancer9.9
47colorectal cancer9.9

Graphical network of the top 20 diseases related to Uterine Disease:



Diseases related to uterine disease

Clinical Features for Uterine Disease

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Drugs & Therapeutics for Uterine Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Uterine Disease

Drug clinical trials:

Search ClinicalTrials for Uterine Disease

Search NIH Clinical Center for Uterine Disease

Search CenterWatch for Uterine Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uterine Disease

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Anatomical Context for Uterine Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Uterine Disease:

32
Uterus, Cervix, Thyroid, Breast, Myeloid, Prostate, Placenta, Monocytes, Lung, Small intestine, Heart

FMA organs/tissues related to Uterine Disease:

14
The uterus

Animal Models for Uterine Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Uterine Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ESR1, CYP19A1, IGFBP1

Publications for Uterine Disease

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Sources:
50PubMed
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Articles related to Uterine Disease:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. (24209779)
2013
2
Observations on the incidence and seasonality of uterine torsion and left displaced abomasum following the 2001 outbreak of foot-and-mouth disease in the UK. (23228514)
2013
3
The influence of primary site on outcomes in leiomyosarcoma: a review of clinicopathologic differences between uterine and extrauterine disease. (22772425)
2013
4
Neuroendocrine carcinoma of the uterine cervix: the role of multimodality therapy in early-stage disease. (23357610)
2013
5
Evaluation of cytokine expression by blood monocytes of lactating Holstein cows with or without postpartum uterine disease. (21924475)
2012
6
Tackling uterine disease in cattle. (22544588)
2012
7
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. (22865295)
2012
8
When do we need to perform laparotomy for benign uterine disease? Factors involved with conversion in vaginal hysterectomy. (21955358)
2012
9
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. (20605134)
2010
10
Unusual Osteoblastic Secondary Lesion as Predominant Metastatic Disease Spread in Two Cases of Uterine Leiomyosarcoma. (20740159)
2010
11
Uterine cervical non-gonococcal and non-chlamydial bacterial flora and its antibiotic sensitivity in women with pelvic inflammatory disease: did it vary over 20 years? (21348403)
2010
12
Bleeding management of uterine conization using a pasteurized FVIII/VWF Concentrate in a woman affected by type 2A von willebrand disease. (18160560)
2009
13
Prolonged disease free survival with aggressive adjuvant chemotherapy in a case of large cell neuroendocrine carcinoma of the uterine cervix. (19650188)
2009
14
The value of minilaparotomy for total hysterectomy for benign uterine disease: a comparative study with conventional Pfannenstiel and laparoscopic approaches. (19386113)
2009
15
Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. (18470523)
2009
16
Failure to detect the presence of prions in the uterine and gestational tissues from a Gravida with Creutzfeldt-Jakob disease. (19349373)
2009
17
Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease. (18980243)
2009
18
Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. (19476661)
2009
19
Postpartum uterine disease and dairy herd reproductive performance: a review. (18328749)
2008
20
Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk. (18691687)
2008
21
Defining postpartum uterine disease in cattle. (16226305)
2006
22
Small bowel obstruction due to adhesive disease observed after uterine fibroid embolization. (16150299)
2005
23
The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. (15581942)
2004
24
von Willebrand's disease: an important cause of dysfunctional uterine bleeding. (11914650)
2002
25
p53 and p21 expression in precancerous lesions and carcinomas of the uterine cervix: overexpression of p53 predicts poor disease outcome. (11606096)
2001
26
Early uterine serous carcinoma: clonal origin of extrauterine disease. (11444195)
2001
27
Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. (9358772)
1997
28
Investigating uterine disease in the bitch: uterine cannulation for cytology, microbiology and hysteroscopy. (7650914)
1995
29
c-erbB-2 oncoprotein overexpression in uterine cervix carcinoma with glandular differentiation. A frequent event but not an independent prognostic marker because it occurs late in the disease. (8526205)
1995
30
Adenomyosis--an ignored uterine disease. (7501319)
1995
31
Adenomyosis--an ignored uterine disease. (7596529)
1995
32
Uterine atypical polypoid adenomyoma and ovarian endometrioid carcinoma: metastatic disease or dual primaries? (7883432)
1995
33
Prophylactic oophorectomy of benign uterine disease in premenopausal women: 11 years review. (7745370)
1994
34
Insulin-like growth factors and their binding proteins in benign and malignant uterine diseases. (7683538)
1993
35
Bovine uterine, cervical and ovarian cytosol estrogen and progesterone receptor concentrations in cystic ovarian disease. (8342463)
1993
36
Dysfunctional uterine bleeding associated with 45X/47XXX mosaicism and Von Willebrand's disease. (3542918)
1986
37
Estimates of the true population at risk of uterine disease and an application to incidence data for cancer of the uterine corpus in Connecticut. (7377178)
1980
38
Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. (377970)
1979
39
Myelomeningocele: a progressive intra-uterine disease. (797606)
1976
40
Plasma progesterone levels in canine uterine disease. (5064888)
1972
41
Uterine disease after the Manchester repair operation. (5458778)
1970
42
Surgical correction of contributory causes of uterine disease in the mare. (5749685)
1968
43
Uterine myoma as a hereditary disease. (13386269)
1957
44
The frequency of hysterectomy for benign uterine disease. (18868374)
1948
45
Radiotherapy for benign uterine disease. (20269642)
1947
46
Recent Advances in Deep X-ray Therapy in Non-malignant and Malignant Uterine Disease. (19988483)
1932
47
MENORRHAGIAS NOT DUE TO UTERINE DISEASE: CAUSATION, CLINICAL FEATURES, AND TREATMENT. (20776403)
1931
48
Syphilis in Relation to Uterine Disease. (19977994)
1914
49
The Treatment of Intra-Uterine Disease. (20751080)
1884
50
On the Treatment of Intra-Uterine Disease: With Special Reference to the Best Mode of Making Applications to the Intra-Uterine Surface. (20751078)
1884

Genetic Variations for Uterine Disease

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Expression for genes affiliated with Uterine Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uterine Disease

Search GEO for disease gene expression data for Uterine Disease.

Pathways for genes affiliated with Uterine Disease

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB
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Pathways related to Uterine Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ESR1, CYP19A1
2
Hide members
9.3ESR1, CYP19A1

Compounds for genes affiliated with Uterine Disease

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Sources:
11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Uterine Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1Chlorotrianisene119.8CYP19A1, ESR1
2nolvadex449.8CYP19A1, ESR1
3vinclozolin449.8CYP19A1, ESR1
4idoxifene449.8CYP19A1, ESR1
5formestane449.8ESR1, CYP19A1
6ment449.8ESR1, CYP19A1
7fadrozole449.7ESR1, CYP19A1
8ibandronate44 1110.7ESR1, CYP19A1
9clomifene49 1110.7ESR1, CYP19A1
10estradiol benzoate449.7CYP19A1, ESR1
11nandrolone44 2410.7CYP19A1, ESR1
12goserelin44 28 1111.7ESR1, CYP19A1
13aminoglutethimide44 1110.7ESR1, CYP19A1
145alpha-androstane-3alpha,17beta-diol449.7ESR1, CYP19A1
15megestrol acetate449.7ESR1, CYP19A1
16leuprolide acetate449.7ESR1, CYP19A1
17risedronate44 59 49 28 1113.7CYP19A1, ESR1
18exemestane49 44 59 1112.7ESR1, CYP19A1
19bisphenol a449.7ESR1, CYP19A1
20lapatinib44 49 1111.6CYP19A1, ESR1
21toremifene44 1110.6ESR1, CYP19A1
22naringenin44 1110.6ESR1, CYP19A1
23tibolone449.6CYP19A1, ESR1
24fulvestrant44 49 28 1112.6CYP19A1, ESR1
25danazol44 11 2411.6ESR1, CYP19A1
26taxane449.5ESR1, CYP19A1
27letrozole44 49 59 1112.5ESR1, CYP19A1
28buserelin44 28 1111.5CYP19A1, IGFBP1
29flutamide44 59 1111.4ESR1, CYP19A1
30droloxifene449.4IGFBP1, ESR1
31estrone sulfate44 2410.4CYP19A1, ESR1
32isoflavone449.4IGFBP1, ESR1
33bicalutamide44 59 1111.3CYP19A1, ESR1
34indole-3-carbinol449.3ESR1, CYP19A1
3517-hydroxyprogesterone44 2410.3IGFBP1, CYP19A1
36steroidal449.2CYP19A1, ESR1
37anastrozole44 1110.0ESR1, CYP19A1, IGFBP1
38clomiphene citrate449.0ESR1, CYP19A1, IGFBP1
39levonorgestrel44 59 28 1112.0IGFBP1, CYP19A1, ESR1
40progestins449.0ESR1, CYP19A1, IGFBP1
41progestin448.9ESR1, CYP19A1, IGFBP1
42mifepristone44 59 28 1111.9ESR1, CYP19A1, IGFBP1
43estrone44 28 11 2411.9IGFBP1, CYP19A1, ESR1
44dihydrotestosterone44 28 11 2411.9IGFBP1, CYP19A1, ESR1
45gnrh448.9IGFBP1, CYP19A1, ESR1
46tamoxifen44 49 28 1111.9IGFBP1, CYP19A1, ESR1
47vitamin d448.9IGFBP1, CYP19A1, ESR1
48estradiol44 11 2410.8IGFBP1, CYP19A1, ESR1
49genistein44 28 59 2 11 2413.8ESR1, CYP19A1, IGFBP1
50cycloheximide448.2ESR1, CYP19A1, IGFBP1

GO Terms for genes affiliated with Uterine Disease

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Sources:
16Gene Ontology
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Biological processes related to Uterine Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.3ESR1, CYP19A1

Products for genes affiliated with Uterine Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet