MCID: UTR038
MIFTS: 37

Uterine Disease malady

Categories: Reproductive diseases

Aliases & Classifications for Uterine Disease

Aliases & Descriptions for Uterine Disease:

Name: Uterine Disease 12 14
Uterine Diseases 52 41 42 69
Uterine Abnormality 52

Characteristics:

HPO:

32
uterine disease:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:345
ICD10 33 N85.9
ICD9CM 35 621.9
MeSH 42 D014591
NCIt 47 C26907
UMLS 69 C0042131

Summaries for Uterine Disease

MedlinePlus : 41 the uterus, or womb, is the place where a baby grows when a woman is pregnant. the first sign of a problem with the uterus may be bleeding between periods or after sex. causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. treatment depends on the cause. sometimes birth control pills treat hormonal imbalances. if a thyroid problem is the cause, treating it may also stop the bleeding. if you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. with two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. in endometriosis, it grows outside the uterus. in adenomyosis, it grows in the uterus's outside walls. pain medicine may help. other treatments include hormones and surgery.

MalaCards based summary : Uterine Disease, also known as uterine diseases, is related to placenta disease and vaginitis, and has symptoms including bicornuate uterus and pelvic pain. An important gene associated with Uterine Disease is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1). The drugs Levonorgestrel and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include uterus, thyroid and neutrophil.

Disease Ontology : 12 A female reproductive system disease that is located in the uterus.

Related Diseases for Uterine Disease

Diseases in the Uterine Disease family:

Uterine Inflammatory Disease

Diseases related to Uterine Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
id Related Disease Score Top Affiliating Genes
1 placenta disease 10.7
2 vaginitis 9.8
3 adenomyosis 9.6
4 sciatic neuropathy 9.4
5 neuropathy 9.4
6 colorectal cancer 9.4
7 endometrial cancer 9.4
8 myelomeningocele 9.4
9 leiomyoma 9.4
10 vulvovaginitis 9.4
11 cervicitis 9.4
12 syphilis 9.4
13 placenta accreta 9.4
14 leiomyomatosis 9.4
15 peritonitis 9.4
16 benign metastasizing leiomyoma 9.4
17 disseminated peritoneal leiomyomatosis 9.4

Graphical network of the top 20 diseases related to Uterine Disease:



Diseases related to Uterine Disease

Symptoms & Phenotypes for Uterine Disease

Human phenotypes related to Uterine Disease:

32
id Description HPO Frequency HPO Source Accession
1 bicornuate uterus 32 HP:0000813

UMLS symptoms related to Uterine Disease:


pelvic pain

Drugs & Therapeutics for Uterine Disease

Drugs for Uterine Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 818)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 797-63-7, 17489-40-6 13109
2
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 71-58-9
3
Norethindrone Approved Phase 4,Phase 3,Phase 2 68-22-4 6230
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
5
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
6
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
7
Lymecycline Approved Phase 4 992-21-2 5280963
8
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
9
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
10
Succinylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2 306-40-1 5314
11
Desogestrel Approved Phase 4,Phase 3,Phase 2 54024-22-5 40973
12
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
13 Dienogest Approved Phase 4,Phase 3,Phase 2 65928-58-7
14
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
15
Nandrolone Approved, Experimental, Illicit Phase 4,Phase 3 434-22-0, 62-90-8 9904 229455
16
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3 360-70-3 9677
17
Ergonovine Approved Phase 4,Phase 3 60-79-7 443884
18
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-56-6 439302 53477758
19
Carbetocin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 37025-55-1 71715 16681432
20
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
21
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
22
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-27-2 5288826
23
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
24
Sufentanil Approved, Investigational Phase 4,Phase 2,Phase 3 56030-54-7 41693
25
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
26
Mefenamic acid Approved Phase 4,Phase 3 61-68-7 4044
27
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
28
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
29
Misoprostol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59122-46-2 5282381
30
Ketorolac Approved Phase 4,Phase 2 74103-06-3, 66635-83-4 3826
31
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
32
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
33
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
34
Cetrorelix Approved, Investigational Phase 4,Phase 3 120287-85-6 16129715 25074887
35
Calcium carbonate Approved Phase 4,Phase 3,Phase 2 471-34-1
36
Tamoxifen Approved Phase 4,Phase 3,Phase 2,Phase 1 10540-29-1 2733526
37
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
38
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53714-56-0 3911 657181
39
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351
40
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
41
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
42
Menthol Approved Phase 4,Phase 3,Phase 1 2216-51-5 16666
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
44
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
45
Ganirelix Approved Phase 4,Phase 3,Phase 2 123246-29-7, 124904-93-4 25081094
46
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
47
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
48
Copper Approved Phase 4,Phase 3,Phase 2,Phase 1 15158-11-9, 7440-50-8 27099
49
Ethanol Approved Phase 4,Phase 2,Phase 1 64-17-5 702
50
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 2938)
id Name Status NCT ID Phase
1 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
2 A Study Comparing Mirena and Systemic Progestin for Endometrial Hyperplasia Unknown status NCT01074892 Phase 4
3 Pretreatment With Norethindrone Acetate Prior to Levonorgestrel IUS Insertion for Heavy Menstrual Bleeding Unknown status NCT01391052 Phase 4
4 A New Treatment Option for Heavy Menstrual Bleeding Unknown status NCT01715025 Phase 4
5 Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China Unknown status NCT01021904 Phase 4
6 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
7 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
8 Can Alternative Treatment Have an Impact on Cervical Dysplasia? Unknown status NCT00842738 Phase 4
9 The Hysteroscopic Morcellator (HM). Unknown status NCT01537822 Phase 4
10 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
11 Upper Vaginectomy Versus Brachytherapy in Patients With Early Stage Endometrial Cancer Treated With Laparoscopic Surgery Unknown status NCT00719017 Phase 4
12 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4
13 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
14 Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine Unknown status NCT01941628 Phase 4
15 Norplant and Irregular Bleeding/Spotting Unknown status NCT00064766 Phase 4
16 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
17 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
18 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Unknown status NCT02480647 Phase 4
19 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
20 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
21 Oxytocin in Cesarean Delivery Unknown status NCT01236482 Phase 4
22 ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery Unknown status NCT01579201 Phase 4
23 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4
24 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4
25 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4
26 MyoSure Hysteroscopic Tissue Removal System Registry Study Unknown status NCT01369758 Phase 4
27 Postpartum Oxygen Inhalation for the Treatment of Postpartum Haemorrhage Unknown status NCT01180192 Phase 4
28 PCC and Fibrinogen Compared With FFP in PPH Unknown status NCT01910675 Phase 4
29 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4
30 Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
31 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
32 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
33 DMPA & High Dose Oral Progestin (MPA) Tablets in Outpatient Treatment of Acute Excessive Vaginal Bleeding Completed NCT01148420 Phase 4
34 Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA) Completed NCT01295294 Phase 4
35 Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia Completed NCT02872818 Phase 4
36 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
37 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
38 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4
39 Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis? Completed NCT01437228 Phase 4
40 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4
41 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
42 Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia Completed NCT01165307 Phase 4
43 Evaluation of Modified Treatment Regimens for Treatment of Heavy Menstrual Bleeding Using the HerOption® System Completed NCT00094536 Phase 4
44 European Active Surveillance Study for Intrauterine Devices Completed NCT00461175 Phase 4
45 Chances for Success of CavatermTM Surgery as a Function of Uterus Probe Length Completed NCT01436903 Phase 4
46 Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding Completed NCT01190150 Phase 4
47 Bleeding Pattern and User Satisfaction During Second Consecutive MIRENA® in Contraception and Treatment of Menorrhagia Completed NCT00393198 Phase 4
48 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4
49 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
50 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4

Search NIH Clinical Center for Uterine Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: uterine diseases

Genetic Tests for Uterine Disease

Anatomical Context for Uterine Disease

MalaCards organs/tissues related to Uterine Disease:

39
Uterus, Thyroid, Neutrophil, Monocytes, Breast, Placenta

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Disease:

18
The Uterus

Publications for Uterine Disease

Articles related to Uterine Disease:

(show top 50) (show all 65)
id Title Authors Year
1
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. ( 27748666 )
2017
2
Hysterectomy for Benign Uterine Disease. ( 27146592 )
2016
3
Vulvovaginal laceration as a risk factor for uterine disease in postpartum dairy cows. ( 27016827 )
2016
4
Uterine disease and its effect on subsequent reproductive performance of dairy cattle: a comparison of two cow-side diagnostic methods. ( 27450885 )
2016
5
Malignant uterine disease with concurrent myometrial contraction at MRI: a possible source of overstaging. ( 27818552 )
2016
6
The effect of puerperal uterine disease on histopathologic findings and mRNA expression of proinflammatory cytokines of the endometrium in dairy cows. ( 26810831 )
2016
7
Early Experience of Robotic Hysterectomy for Treatment of Benign Uterine Disease. ( 27643518 )
2016
8
Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis. ( 26261478 )
2015
9
Laparoendoscopic single-site versus conventional laparoscopic-assisted vaginal hysterectomy for benign or pre-invasive uterine disease. ( 25106721 )
2014
10
MRI appearances of benign uterine disease. ( 25017452 )
2014
11
Differential endometrial cell sensitivity to a cholesterol-dependent cytolysin links Trueperella pyogenes to uterine disease in cattle. ( 24478394 )
2014
12
Routes of hysterectomy in women with benign uterine disease in the Vancouver Coastal Health and Providence Health Care regions: a retrospective cohort analysis. ( 25485254 )
2014
13
Mucin 1 and cytokines mRNA in endometrium of dairy cows with postpartum uterine disease or repeat breeding. ( 24576715 )
2014
14
Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. ( 24209779 )
2013
15
The effect of puerperal uterine disease on uterine involution in cows assessed by Doppler sonography of the uterine arteries. ( 24275717 )
2013
16
Drivers of post-partum uterine disease in dairy cattle. ( 23962215 )
2013
17
Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. ( 22284667 )
2012
18
When do we need to perform laparotomy for benign uterine disease? Factors involved with conversion in vaginal hysterectomy. ( 21955358 )
2012
19
Evaluation of cytokine expression by blood monocytes of lactating Holstein cows with or without postpartum uterine disease. ( 21924475 )
2012
20
Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. ( 23021755 )
2012
21
Tackling uterine disease in cattle. ( 22544588 )
2012
22
The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. ( 21918977 )
2012
23
Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. ( 22865295 )
2012
24
AAGL position statement: route of hysterectomy to treat benign uterine disease. ( 21059487 )
2011
25
A prospective randomized comparison of vaginal hysterectomy, laparoscopically assisted vaginal hysterectomy, and total laparoscopic hysterectomy in women with benign uterine disease. ( 19926201 )
2010
26
Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows. ( 20630210 )
2010
27
Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. ( 19476661 )
2009
28
Plasma PGF 2 alpha metabolite levels in cats with uterine disease. ( 19748114 )
2009
29
Risk assessment of postpartum uterine disease and consequences of puerperal metritis for subsequent metabolic status, reproduction and milk yield in dairy cows. ( 19457784 )
2009
30
The value of minilaparotomy for total hysterectomy for benign uterine disease: a comparative study with conventional Pfannenstiel and laparoscopic approaches. ( 19386113 )
2009
31
Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. ( 19439727 )
2009
32
When is laparotomy needed in hysterectomy for benign uterine disease? ( 18262142 )
2008
33
Postpartum uterine disease and dairy herd reproductive performance: a review. ( 18328749 )
2008
34
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease. ( 18577555 )
2008
35
MR imaging of benign uterine disease. ( 17433976 )
2006
36
Defining postpartum uterine disease in cattle. ( 16226305 )
2006
37
MR imaging of malignant uterine disease. ( 17433977 )
2006
38
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. ( 16109840 )
2005
39
Combination of a tension-free vaginal tape procedure and laparoscopic-assisted vaginal hysterectomy for the treatment of benign uterine disease associated with stress urinary incontinence. ( 15945323 )
2005
40
Evaluation of a device for objective determination of cervical consistency: a pilot study of device's validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease. ( 12442598 )
2002
41
Vaginal hysterectomy for benign uterine disease in the laparoscopically confirmed frozen pelvis. ( 9449083 )
1997
42
Ovarian and uterine disease in women with colorectal cancer. ( 8990444 )
1997
43
The place of hysterectomy in the management of benign uterine disease. ( 10158543 )
1996
44
Adenomyosis--an ignored uterine disease. ( 7501319 )
1995
45
Investigating uterine disease in the bitch: uterine cannulation for cytology, microbiology and hysteroscopy. ( 7650914 )
1995
46
Adenomyosis--an ignored uterine disease. ( 7596529 )
1995
47
Prophylactic oophorectomy of benign uterine disease in premenopausal women: 11 years review. ( 7745370 )
1994
48
Insulin-like growth factors and their binding proteins in benign and malignant uterine diseases. ( 7683538 )
1993
49
Histopathologic features, environmental factors, and serum estrogen, progesterone, and prolactin values associated with ovarian phase and inflammatory uterine disease in cats. ( 1768001 )
1991
50
Increased risk of malignancy and uterine disease following perimenarchal hospitalization: an estrogen window effect. ( 6623355 )
1983

Variations for Uterine Disease

Expression for Uterine Disease

Search GEO for disease gene expression data for Uterine Disease.

Pathways for Uterine Disease

GO Terms for Uterine Disease

Sources for Uterine Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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