MCID: UTR039
MIFTS: 49

Uterine Fibroid malady

Cancer diseases category

Summaries for Uterine Fibroid

About this section
Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Uterine fibroids are the most common benign tumors in women of childbearing age. fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. the cause of fibroids is unknown. risk factors include being african american or being overweight. many women with fibroids have no symptoms. if you do have symptoms, they may include heavy or painful periods or bleeding between periods feeling "full" in the lower abdomen urinating often pain during sex lower back pain reproductive problems, such as infertility, multiple miscarriages or early labor your health care provider may find fibroids during a gynecological exam or by using imaging tests. treatment includes drugs that can slow or stop their growth, or surgery. if you have no symptoms, you may not even need treatment. many women with fibroids can get pregnant naturally. for those who cannot, infertility treatments may help. nih: national institute of child health and human development

MalaCards: Uterine Fibroid, also known as plexiform leiomyoma, is related to leiomyoma and leiomyosarcoma. An important gene associated with Uterine Fibroid is FH (fumarate hydratase), and among its related pathways is Vitamin A and carotenoid metabolism. The compounds retinoic acid and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and testes.

Wikipedia:63 A uterine fibroid is a leiomyoma (benign tumor from smooth muscle tissue) that originates from the... more...

Description from OMIM:46 150699

Aliases & Classifications for Uterine Fibroid

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 39NCIt, 56SNOMED-CT, 27ICD9CM, 46OMIM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

uterine fibroid 8 10
plexiform leiomyoma 8 60
uterine leiomyoma 8 44
uterine fibroids 33 60
leiomyoma of uterus, unspecified 8
leiomyoma of corpus uteri 8
uterine leiomyoma nos 8
uterus fibroma 8


External Ids:

Disease Ontology8 DOID:13223
NCIt39 C3434
ICD9CM27 218, 218.9
OMIM46 150699
MeSH34 D007889
ICD1025 D25.9

Related Diseases for Uterine Fibroid

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Uterine Fibroid:



Diseases related to uterine fibroid

Clinical Features for Uterine Fibroid

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

150699

Drugs & Therapeutics for Uterine Fibroid

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uterine Fibroid

Drug clinical trials:

Search ClinicalTrials for Uterine Fibroid

Search NIH Clinical Center for Uterine Fibroid

Search CenterWatch for Uterine Fibroid

Genetic Tests for Uterine Fibroid

About this section

Anatomical Context for Uterine Fibroid

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Uterine Fibroid:

32
Uterus, Smooth muscle, Testes, Kidney, Spleen, Endothelial, Cervix, Skin, Breast, Heart, Pituitary

Animal Models for Uterine Fibroid or affiliated genes

About this section

Publications for Uterine Fibroid

About this section
Sources:
50PubMed
See all sources

Articles related to Uterine Fibroid:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Acute hemorrhage related to spontaneous rupture of an uterine fibroid: a rare case report. (23967563)
2013
2
Comparison of the efficacy of dexmedetomidine plus fentanyl patient-controlled analgesia with fentanyl patient-controlled analgesia for pain control in uterine artery embolization for symptomatic fibroid tumors or adenomyosis: a prospective, randomized study. (23707085)
2013
3
Utero-ovarian anastomoses and their influence on uterine fibroid embolization. (22440591)
2012
4
MED12 mutations in uterine fibroids--their relationship to cytogenetic subgroups. (22223266)
2012
5
Uterine fibroid pseudocapsule studied by transmission electron microscopy. (22445207)
2012
6
Hysteroscopy after uterine fibroid embolization: evaluation of intrauterine findings in 127 patients. (22413922)
2012
7
The timing of natural menopause after uterine fibroid embolization: a prospective cohort study. (21802673)
2011
8
Non puerperal uterine inversion due to submucous fibroid: a case report. (21670787)
2011
9
Activin-A and myostatin response and steroid regulation in human myometrium: disruption of their signalling in uterine fibroid. (21177794)
2011
10
Alternatives to hysterectomy: focus on global endometrial ablation, uterine fibroid embolization, and magnetic resonance-guided focused ultrasound. (21701430)
2011
11
Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids. (19368910)
2010
12
Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids. (19639498)
2010
13
Cell culture and senescence in uterine fibroids. (20804922)
2010
14
Uterine fibroid treatment patterns in a population of insured women. (18304543)
2009
15
MR venography of deep veins: changes with uterine fibroid embolization. (19011939)
2009
16
Family history of uterine fibroids associated with low level of fumarate hydratase in leiomyomata cells. (19595497)
2009
17
Uterine fibroid embolization. (19967821)
2009
18
Long-term quality of life assessment among patients undergoing uterine fibroid embolization. (19542423)
2009
19
Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice. (18468574)
2008
20
Incidence, aetiology and epidemiology of uterine fibroids. (18534913)
2008
21
A systematic review of randomized controlled trials to reduce hemorrhage during myomectomy for uterine fibroids. (17894936)
2008
22
Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation. (18701604)
2008
23
Management options for uterine fibroid tumors. (17555138)
2007
24
Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study. (17327552)
2007
25
The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids. (17224149)
2007
26
The effect of uterine fibroids on embryo implantation. (17960533)
2007
27
Health care resource use for uterine fibroid tumors in the United States. (16723104)
2006
28
The positive effect of targeted marketing on an existing uterine fibroid embolization practice. (16567685)
2006
29
Effectiveness of intra-arterial anesthesia for uterine fibroid embolization using dilute lidocaine. (15696287)
2005
30
Disintegration and stepwise expulsion of a large uterine leiomyoma with restoration of the uterine architecture after successful uterine fibroid embolization: case report. (12660286)
2003
31
Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. (12861137)
2003
32
Doppler-ultrasound as a predictor of uterine fibroid response to GnRH therapy. (12834940)
2003
33
Uterine fibroid embolization. (12455133)
2002
34
Uterine fibroid embolization fares well against hysterectomy, study says. (12467267)
2002
35
III. Uterine fibroid embolization: pain management. (12098106)
2002
36
Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids. (10796723)
2000
37
Treatment of uterine fibroid tumors in a nude mouse model using high-intensity focused ultrasound. (10920300)
2000
38
Migraine with ectopic hyperprolactinemia from uterine fibroids. (10891931)
2000
39
By the way, doctor. I am 59 years old, in good health, and have been on HRT (estrogen and progesterone) for about 10 years. I have tried several different preparations, but despite this, have developed a uterine fibroid, experienced indigestion, gained 20 pounds, and had one abnormal mammogram (with, thankfully, a negative biopsy). Because there is heart disease in my family, my doctor wants me to stay on HRT for the rest of my life. Can you suggest any alternatives? (10594971)
2000
40
Uterine fibroid embolization: another paradigm shift for interventional radiology? (10527189)
1999
41
Pedunculated uterine fibroid simulating an incarcerated inguinal hernia in pregnancy. (8141189)
1994
42
Luteinizing hormone-releasing hormone analog therapy of uterine fibroid: analysis of results obtained with buserelin administered intranasally and goserelin administered subcutaneously as a monthly depot. (2142921)
1990
43
Leiomyosarcoma in the mesentery presenting as a uterine fibroid. (7326631)
1981
44
Giant uterine fibroid in pregnancy. (632040)
1978
45
Letter: Rapid enlargement of a uterine fibroid after clomiphene therapy. (1137711)
1975
46
Paraplegia caused by extraspinal metastasis from a uterine fibroid. (13655105)
1959
47
Rupture of the Uterus Occurring at the Time of Removal per vaginam of a Pedunculated Uterine Fibroid. (19993859)
1955
48
An unusual sub-mucous uterine fibroid. (14955731)
1952
49
Extensive Retroperitoneal Haematocele complicating a large Uterine Fibroid: Operation: Cure. (19974542)
1910
50
A CASE OF TRANSPLANTED UTERINE FIBROID GIVING RISE TO INTESTINAL OBSTRUCTION. (20760640)
1903

Genetic Variations for Uterine Fibroid

About this section

Expression for genes affiliated with Uterine Fibroid

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uterine Fibroid

Search GEO for disease gene expression data for Uterine Fibroid.

Pathways for genes affiliated with Uterine Fibroid

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Uterine Fibroid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5ADH1A, RBP1, CRABP2

Compounds for genes affiliated with Uterine Fibroid

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Uterine Fibroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.7ADH1A, GNRH1, TFAP2C, CRABP2, RBP1, MMP11
2vitamin a44 11 2412.7CRABP2, RBP1, PAEP, ADH1A
3retinoid4410.6ADH1A, RARRES3, RBP1, CRABP2
4progesterone44 59 28 11 2414.6GNRH1, RBP1, DUSP13, MMP11, PAEP
5nad+4410.6SIRT3, RBP1, FH
6steroid4410.5GNRH1, CRABP2, RBP1, MMP11, PAEP
7tibolone4410.5PAEP, GNRH1
8buserelin44 28 1112.4PAEP, GNRH1
9clomiphene citrate4410.2PAEP, GNRH1

GO Terms for genes affiliated with Uterine Fibroid

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Uterine Fibroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organismal developmentGO:00727510.5PAEP, MMP11, GNRH1, ODF3

Molecular functions related to Uterine Fibroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol bindingGO:01984110.5RBP1, CRABP2
2retinoid bindingGO:00550110.4RBP1, CRABP2
3retinal bindingGO:01691810.2RBP1, CRABP2

Products for genes affiliated with Uterine Fibroid

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Fibroid

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet