Aliases & Classifications for Uterine Fibroid

Aliases & Descriptions for Uterine Fibroid:

Name: Uterine Fibroid 12 14
Plexiform Leiomyoma 12 69
Uterine Leiomyoma 12 52
Uterine Fibroids 41 69
Leiomyoma of Corpus Uteri 12
Leiomyoma, Uterine 29
Uterus Fibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13223
ICD10 33 D25 D25.9
ICD9CM 35 218 218.9
MeSH 42 D007889
NCIt 47 C3434
UMLS 69 C0042133

Summaries for Uterine Fibroid

MedlinePlus : 41 uterine fibroids are the most common benign tumors in women of childbearing age. fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. the cause of fibroids is unknown. risk factors include being african american or being overweight. many women with fibroids have no symptoms. if you do have symptoms, they may include heavy or painful periods or bleeding between periods feeling "full" in the lower abdomen urinating often pain during sex lower back pain reproductive problems, such as infertility, multiple miscarriages or early labor your health care provider may find fibroids during a gynecological exam or by using imaging tests. treatment includes drugs that can slow or stop their growth, or surgery. if you have no symptoms, you may not even need treatment. many women with fibroids can get pregnant naturally. for those who cannot, infertility treatments may help. nih: national institute of child health and human development

MalaCards based summary : Uterine Fibroid, also known as plexiform leiomyoma, is related to endometriosis and submucous uterine fibroid, and has symptoms including pelvic pain An important gene associated with Uterine Fibroid is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and NF-KappaB Family Pathway. The drugs Desogestrel and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and testes, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Disease Ontology : 12 A uterine benign neoplasm derived from the smooth muscle layer of the uterus.

Wikipedia : 71 Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the... more...

Related Diseases for Uterine Fibroid

Diseases related to Uterine Fibroid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
id Related Disease Score Top Affiliating Genes
1 endometriosis 30.2 GNRH1 PRL
2 submucous uterine fibroid 12.1
3 subserous uterine fibroid 12.1
4 multiple cutaneous and uterine leiomyomas 12.1
5 leiomyoma, uterine, somatic 12.0
6 leiomyoma 11.4
7 uterine corpus bizarre leiomyoma 11.0
8 intravenous leiomyomatosis 11.0
9 myofibroma 11.0
10 uterine corpus apoplectic leiomyoma 10.9
11 uterine corpus epithelioid leiomyoma 10.9
12 uterine corpus dissecting leiomyoma 10.9
13 uterine corpus myxoid leiomyoma 10.9
14 transitional papilloma 10.3 HMGA2 IGF2
15 pericardium leiomyoma 10.3 MED12 PGR
16 bartholin's gland benign neoplasm 10.2 ESR1 PGR
17 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
18 appendix leiomyoma 10.2 ESR1 PGR
19 bronchus adenoma 10.2 ESR1 PGR
20 glioma 10.2 ESR1 PGR
21 ovarian benign neoplasm 10.2 ESR1 PGR
22 skin sarcoma 10.2 PGR PRL
23 plexiform neurofibroma 10.2 ESR1 PGR
24 thrombophilia 10.2 IGF1 IGF2 PRL
25 ring chromosome 2 10.2 HMGA1 HMGA2
26 paranasal sinus disease 10.2 ESR1 PGR
27 african histoplasmosis 10.2 GNRH1 PRL
28 endocrine organ benign neoplasm 10.2 IGF1 PGR PRL
29 benign fibrous mesothelioma 10.2 EGF ESR1
30 malignant mixed mullerian tumor 10.2 HMGA1 HMGA2
31 deafness, autosomal recessive 21 10.2 ESR1 PGR
32 urethra clear cell adenocarcinoma 10.2 GNRH1 IGF1 PRL
33 bile acid synthesis defect, congenital, 4 10.2 GNRH1 IGF1 PRL
34 papillary craniopharyngioma 10.2 GNRH1 IGF1 PRL
35 capillary lymphangioma 10.2 GNRH1 IGF1 PRL
36 cervical lymphoepithelioma-like carcinoma 10.2 ESR1 PGR
37 her2-receptor positive breast cancer 10.2 EGF ESR1 PGR
38 adenosarcoma 10.1 FH IGF2 PGR
39 acute myocarditis 10.1 HMGA1 HMGA2
40 adult medulloblastoma 10.1 EGF GNRH1 IGF1
41 pilar sheath acanthoma 10.1 ESR1 HMGA2 PGR
42 metagonimiasis 10.1 ESR1 MMP2 PGR
43 adenomyosis 10.1
44 astroblastoma 10.1 GNRH1 PGR PRL
45 dental caries 10.1 ESR1 MMP2 PGR
46 nasal cavity disease 10.1 ESR1 MMP2 PGR
47 vestibular gland benign neoplasm 10.1 FH HMGA2 IGF1 PRL
48 histiocytic and dendritic cell cancer 10.1 ESR1 PGR
49 spinocerebellar ataxia, autosomal recessive 2 10.1 ESR1 MMP2 PGR
50 atypical lipomatous tumor 10.1 ESR1 PGR

Comorbidity relations with Uterine Fibroid via Phenotypic Disease Network (PDN):


Asherman's Syndrome Cervix Uteri Carcinoma in Situ
Chronic Salpingo-Oophoritis Endometriosis
Endometriosis of Ovary Endometriosis of Uterus
Female Stress Incontinence Hemometra
Ovarian Cancer, Somatic Salpingo-Oophoritis

Graphical network of the top 20 diseases related to Uterine Fibroid:



Diseases related to Uterine Fibroid

Symptoms & Phenotypes for Uterine Fibroid

UMLS symptoms related to Uterine Fibroid:


pelvic pain

GenomeRNAi Phenotypes related to Uterine Fibroid according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 FH IGF2 RAD51B

MGI Mouse Phenotypes related to Uterine Fibroid:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 COMT CYP19A1 ESR1 FH GNRH1 IGF1
2 immune system MP:0005387 10.2 COMT CYP19A1 EGF ESR1 GNRH1 IGF1
3 cardiovascular system MP:0005385 10.16 COMT CYP19A1 ESR1 IGF1 IGF2 MED12
4 endocrine/exocrine gland MP:0005379 10.15 COMT CYP19A1 EGF ESR1 GNRH1 IGF1
5 integument MP:0010771 10.03 ESR1 GNRH1 IGF1 IGF2 PGR PRL
6 nervous system MP:0003631 10.02 CYP19A1 ESR1 GNRH1 IGF1 IGF2 MED12
7 normal MP:0002873 9.91 MED12 MMP2 PGR TGFB3 CYP19A1 EGF
8 limbs/digits/tail MP:0005371 9.88 IGF2 MED12 PGR TGFB3 ESR1 IGF1
9 neoplasm MP:0002006 9.85 ESR1 GNRH1 IGF1 MMP2 PGR PRL
10 renal/urinary system MP:0005367 9.7 COMT CYP19A1 ESR1 FH GNRH1 IGF1
11 reproductive system MP:0005389 9.61 COMT CYP19A1 EGF ESR1 GNRH1 IGF1
12 skeleton MP:0005390 9.28 MMP2 PGR TGFB3 CYP19A1 ESR1 GNRH1

Drugs & Therapeutics for Uterine Fibroid

Drugs for Uterine Fibroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2 Dienogest Approved Phase 4 65928-58-7
3
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
4
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Dimenhydrinate Approved Phase 4 523-87-5 441281
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Calcium carbonate Approved Phase 4,Phase 3 471-34-1
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 3911 657181
10
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
11
Zinc Approved Phase 4 7440-66-6 32051 23994
12
Zinc oxide Approved Phase 4 1314-13-2
13
Ethanol Approved Phase 4 64-17-5 702
14
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Dinoprostone Approved Phase 4 363-24-6 5280360
21
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
22
Prilocaine Approved Phase 4 721-50-6 4906
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Remifentanil Approved Phase 4 132875-61-7 60815
25
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
26
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
27
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
29
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
30
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
31
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
32
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
33
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
34
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
35
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
36
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
39
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
40
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
41
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
42
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
43
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
44
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
45
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
46 tannic acid Approved, Nutraceutical Phase 4
47 Anabolic Agents Phase 4
48 Androgens Phase 4
49 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
50 Contraceptive Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 306)
id Name Status NCT ID Phase
1 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
2 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
3 MyoSure Hysteroscopic Tissue Removal System Registry Study Unknown status NCT01369758 Phase 4
4 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4
5 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
6 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4
7 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
8 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
9 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
10 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4
11 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
12 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
13 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4
14 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4
15 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
16 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
17 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4
18 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4
19 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4
20 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4
21 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4
22 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4
23 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4
24 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4
25 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4
26 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4
27 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4
28 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4
30 Uterine Leiomyoma Treatment With Radiofrequency Ablation Active, not recruiting NCT01840124 Phase 4
31 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Active, not recruiting NCT00995878 Phase 4
32 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4
33 Laparoscopic Uterine Sparing Techniques Outcomes and Reinterventions Active, not recruiting NCT01750008 Phase 4
34 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
35 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4
36 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Not yet recruiting NCT02440750 Phase 4
37 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
38 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
39 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
40 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4
41 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
42 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3
43 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
44 Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Unknown status NCT01715597 Phase 3
45 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
46 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
47 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
48 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3
49 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3
50 Mifepristone for Treatment of Uterine Fibroids Completed NCT00712595 Phase 2, Phase 3

Search NIH Clinical Center for Uterine Fibroid

Genetic Tests for Uterine Fibroid

Genetic tests related to Uterine Fibroid:

id Genetic test Affiliating Genes
1 Uterine Leiomyoma 29

Anatomical Context for Uterine Fibroid

MalaCards organs/tissues related to Uterine Fibroid:

39
Uterus, Smooth Muscle, Testes, Kidney, Breast, Endothelial, Pituitary

Publications for Uterine Fibroid

Articles related to Uterine Fibroid:

(show top 50) (show all 389)
id Title Authors Year
1
Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. ( 28089575 )
2017
2
Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire. ( 27733082 )
2017
3
Effect of the degree of magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroid tissue on 6-month volume reduction. ( 28084010 )
2017
4
Uterine fibroid embolization with acrylamido polyvinyl microspheres: prospective 12-month clinical and MRI follow-up study. ( 27872351 )
2016
5
Degenerated uterine fibroid with rupture of the surface leading to haemoperitoneum. ( 27988218 )
2016
6
Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation. ( 26973527 )
2016
7
A Case of Pyomyoma following Uterine Fibroid Embolization and a Review of the Literature. ( 27066283 )
2016
8
Hyperkalemia and acute kidney failure associated with preoperative uterine artery embolization for a large uterine fibroid: a case report. ( 27799061 )
2016
9
Greater Cephalad Extent of Thoracic Epidural Sensory Anesthesia After Lidocaine and Epinephrine Test Dose Correlates With Analgesic Consumption and Pain Burden After Uterine Fibroid Artery Embolization. ( 26587675 )
2016
10
Lower Serum Levels of Uric Acid in Uterine Fibroids and Fibrocystic Breast Disease Patients in Dongying City, China. ( 27398332 )
2016
11
Expulsion of a Uterine Fibroid into the Small Bowel through Uteroenteric Fistula Presenting with Bowel Obstruction after Uterine Fibroid Embolization: Case Report with Histopathologic Correlation. ( 27106649 )
2016
12
Red degeneration of a uterine fibroid following the administration of gonadotropin releasing hormone agonists. ( 27750451 )
2016
13
Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study. ( 27371355 )
2016
14
Tunable delivery of niflumic acid from resorbable embolization microspheres for uterine fibroid embolization. ( 27374196 )
2016
15
Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells. ( 27020169 )
2016
16
Uterine Fibroid (Leiomyoma) with Acute Urinary Retention: A Case Series. ( 27190903 )
2016
17
18F-FDG PET/CT Demonstrating Malignant Degeneration of a Uterine Fibroid. ( 27556790 )
2016
18
Updates in uterine fibroid tissue extraction. ( 27253236 )
2016
19
The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI. ( 27867814 )
2016
20
Herpes Simplex Virus Type 2 Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. ( 27188945 )
2016
21
Uterine fibroid characteristics and sonographic pattern among Ghanaian females undergoing pelvic ultrasound scan: a study at 3-major centres. ( 26884233 )
2016
22
Spontaneous Pregnancy Following Ulipristal Acetate Treatment in a Woman with a Symptomatic Uterine Fibroid. ( 26872760 )
2016
23
Vitamin D3 Inhibits Wnt/I^-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells. ( 26820714 )
2016
24
Uterine fibroid management: from the present to the future. ( 27466209 )
2016
25
Converting of Myometrial Stem Cells to Tumor-Initiating Cells: Mechanism of Uterine Fibroid Development. ( 28042616 )
2016
26
Intravoxel incoherent motion diffusion-weighted imaging in differentiating uterine fibroid from focal adenomyosis: initial results. ( 26759748 )
2016
27
Uterine Fibroid Symptom - Quality of Life questionnaire translation and validation into Brazilian Portuguese. ( 27832674 )
2016
28
The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids. ( 26888970 )
2016
29
Uterine fibroid: From pathogenesis to clinical management. ( 26969399 )
2016
30
Risk of Occult Uterine Sarcoma in Presumed Uterine Fibroids. ( 26645385 )
2016
31
Urinary isoflavone and lignan phytoestrogen levels and risk of uterine fibroid in Jamaican women. ( 26223581 )
2015
32
Uterine fibroid: common features of widespread tumor (Review article). ( 26774633 )
2015
33
Feasibility, Safety, and Efficacy of Accurate Uterine Fibroid Ablation Using Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound With Shot Sonication. ( 26518278 )
2015
34
Evaluation of GWAS candidate susceptibility loci for uterine leiomyoma in the multi-ethnic NIEHS uterine fibroid study. ( 26236334 )
2015
35
Surgical Methods for the Treatment of Uterine Fibroids - Risk of Uterine Sarcoma and Problems of Morcellation: Position Paper of the DGGG. ( 25797958 )
2015
36
Uterine fibroid embolization for symptomatic fibroids: study at a teaching hospital in kenya. ( 25883858 )
2015
37
Segmentation of uterine fibroid ultrasound images using a dynamic statistical shape model in HIFU therapy. ( 26459767 )
2015
38
Genetic determinants of uterine fibroid size in the multiethnic NIEHS uterine fibroid study. ( 26417400 )
2015
39
Clinical Long-Term Outcome and Reinterventional Rate After Uterine Fibroid Embolization with Nonspherical Versus Spherical Polyvinyl Alcohol Particles. ( 26122738 )
2015
40
Three-Dimensional Quantitative Assessment of Uterine Fibroid Response after Uterine Artery Embolization Using Contrast-Enhanced MR Imaging. ( 25638750 )
2015
41
1,25-dihydroxyvitamin d3 regulates expression of sex steroid receptors in human uterine fibroid cells. ( 25625804 )
2015
42
Ulipristal acetate for uterine fibroid-related symptoms. ( 26744741 )
2015
43
Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids. ( 25325994 )
2015
44
A Prospective, Ultrasound-Based Study to Evaluate Risk Factors for Uterine Fibroid Incidence and Growth: Methods and Results of Recruitment. ( 26334691 )
2015
45
Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study. ( 25840272 )
2015
46
A Split-and-Merge-Based Uterine Fibroid Ultrasound Image Segmentation Method in HIFU Therapy. ( 25973906 )
2015
47
Role of vitamin D in uterine fibroid biology. ( 26079694 )
2015
48
Laparoscopic hysterectomy with morcellation for a suspected uterine fibroid resulting in dissemination of cervical adenocarcinoma: A case report. ( 26076147 )
2015
49
Therapeutic management of uterine fibroid tumors. ( 26698838 )
2015
50
Prescription patterns of Chinese herbal products for patients with uterine fibroid in Taiwan: A nationwide population-based study. ( 26051833 )
2015

Variations for Uterine Fibroid

Copy number variations for Uterine Fibroid from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 70739 12 64503703 64646338 Duplication HMGA2 Uterine leiomyoma
2 230938 8 100959547 100975071 Translate COX6C Uterine leiomyoma

Expression for Uterine Fibroid

Search GEO for disease gene expression data for Uterine Fibroid.

Pathways for Uterine Fibroid

GO Terms for Uterine Fibroid

Cellular components related to Uterine Fibroid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.96 HMGA1 HMGA2
2 platelet alpha granule lumen GO:0031093 8.92 EGF IGF1 IGF2 TGFB3

Biological processes related to Uterine Fibroid according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.95 ESR1 HMGA1 HMGA2 IGF1 MED12 PGR
2 positive regulation of cell proliferation GO:0008284 9.89 EGF HMGA2 IGF1 IGF2 PRL
3 cellular protein metabolic process GO:0044267 9.78 IGF1 IGF2 MMP2 PRL
4 phosphatidylinositol-mediated signaling GO:0048015 9.77 EGF IGF1 TNRC6B
5 activation of MAPK activity GO:0000187 9.74 EGF IGF1 TGFB3
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 EGF IGF1 IGF2
7 platelet degranulation GO:0002576 9.62 EGF IGF1 IGF2 TGFB3
8 mammary gland alveolus development GO:0060749 9.6 EGF ESR1
9 androgen metabolic process GO:0008209 9.58 CYP19A1 ESR1
10 intracellular steroid hormone receptor signaling pathway GO:0030518 9.58 ESR1 MED12
11 uterus development GO:0060065 9.56 CYP19A1 ESR1
12 positive regulation of glycogen biosynthetic process GO:0045725 9.55 IGF1 IGF2
13 positive regulation of transcription regulatory region DNA binding GO:2000679 9.54 HMGA2 IGF1
14 ovulation cycle GO:0042698 9.51 GNRH1 PRL
15 positive regulation of cellular senescence GO:2000774 9.46 HMGA1 HMGA2
16 embryonic neurocranium morphogenesis GO:0048702 9.43 MED12 TGFB3
17 senescence-associated heterochromatin focus assembly GO:0035986 9.37 HMGA1 HMGA2
18 positive regulation of mitotic nuclear division GO:0045840 9.33 EGF IGF1 IGF2
19 oncogene-induced cell senescence GO:0090402 9.26 HMGA1 HMGA2
20 female pregnancy GO:0007565 9.26 COMT GNRH1 PRL TGFB3
21 positive regulation of transcription, DNA-templated GO:0045893 9.17 EGF ESR1 HMGA1 HMGA2 IGF1 MED12

Molecular functions related to Uterine Fibroid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.67 ESR1 HMGA1 HMGA2 MED12
2 insulin-like growth factor receptor binding GO:0005159 9.4 IGF1 IGF2
3 DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 9.32 HMGA1 HMGA2
4 growth factor activity GO:0008083 9.26 EGF IGF1 IGF2 TGFB3
5 AT DNA binding GO:0003680 9.16 HMGA1 HMGA2
6 hormone activity GO:0005179 8.92 GNRH1 IGF1 IGF2 PRL
7 protein binding GO:0005515 10.13 COMT EGF ESR1 FH HMGA1 HMGA2

Sources for Uterine Fibroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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