Aliases & Classifications for Uterine Fibroid

MalaCards integrated aliases for Uterine Fibroid:

Name: Uterine Fibroid 12 14
Uterine Leiomyoma 12 29 52
Plexiform Leiomyoma 12 69
Uterine Fibroids 41 69
Leiomyoma of Corpus Uteri 12
Uterus Fibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13223
ICD10 33 D25 D25.9
ICD9CM 35 218 218.9
MeSH 42 D007889
NCIt 47 C3434
UMLS 69 C0042133

Summaries for Uterine Fibroid

MedlinePlus : 41 uterine fibroids are the most common benign tumors in women of childbearing age. fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. the cause of fibroids is unknown. risk factors include being african american or being overweight. many women with fibroids have no symptoms. if you do have symptoms, they may include heavy or painful periods or bleeding between periods feeling "full" in the lower abdomen urinating often pain during sex lower back pain reproductive problems, such as infertility, multiple miscarriages or early labor your health care provider may find fibroids during a gynecological exam or by using imaging tests. treatment includes drugs that can slow or stop their growth, or surgery. if you have no symptoms, you may not even need treatment. many women with fibroids can get pregnant naturally. for those who cannot, infertility treatments may help. nih: national institute of child health and human development

MalaCards based summary : Uterine Fibroid, also known as uterine leiomyoma, is related to lactic acidosis and submucous uterine fibroid, and has symptoms including pelvic pain An important gene associated with Uterine Fibroid is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and NF-KappaB Family Pathway. The drugs Desogestrel and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and testes, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism

Disease Ontology : 12 A uterine benign neoplasm derived from the smooth muscle layer of the uterus.

Wikipedia : 72 Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the... more...

Related Diseases for Uterine Fibroid

Diseases related to Uterine Fibroid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 lactic acidosis 29.8 GNRH1 PRL
2 submucous uterine fibroid 12.1
3 subserous uterine fibroid 12.1
4 multiple cutaneous and uterine leiomyomas 12.1
5 intravenous leiomyomatosis 11.0
6 transitional papilloma 10.8 HMGA2 IGF2
7 central nervous system tuberculosis 10.7 MED12 PGR
8 leiomyoma cutis 10.7 MED12 PGR
9 skin sarcoma 10.7 PGR PRL
10 benign fibrous mesothelioma 10.6 EGF ESR1
11 bartholin's gland benign neoplasm 10.6 ESR1 PGR
12 central nervous system organ benign neoplasm 10.6 ESR1 PGR
13 gallbladder leiomyoma 10.6 ESR1 PGR
14 african histoplasmosis 10.6 GNRH1 PRL
15 lung adenoma 10.6 ESR1 PGR
16 olfactory nerve neoplasm 10.6 PGR PRL
17 glaucoma, hereditary 10.6 ESR1 PGR
18 fallopian tube benign neoplasm 10.6 ESR1 PGR
19 paranasal sinus disease 10.6 ESR1 PGR
20 dartoic leiomyoma 10.6 ESR1 PGR
21 lacrimal duct obstruction 10.6 IGF1 IGF2
22 prostate leiomyoma 10.6 GNRH1 PRL
23 osteoclast-like giant cell neoplasm of the pancreas 10.6 PGR PRL
24 aromatic l-amino acid decarboxylase deficiency 10.5 HMGA2 IGF1 IGF2
25 complement component 8 deficiency 10.5 GNRH1 IGF1
26 urinary bladder inverted papilloma 10.5 ESR1 PGR
27 vestibular gland benign neoplasm 10.5 IGF1 PGR PRL
28 ring chromosome 13 10.5 HMGA1 HMGA2
29 spinal cancer 10.5 ESR1 PGR
30 adenomatoid tumor 10.5 GNRH1 PRL
31 subglottis verrucous carcinoma 10.5 ESR1 PGR
32 deafness, autosomal dominant 8/12 10.5 ESR1 PGR
33 intermittent squint 10.5 GNRH1 PRL
34 lymphoepithelioma-like carcinoma 10.5 GNRH1 PRL
35 intestinal perforation 10.5 ESR1 PGR
36 gastric tubular adenocarcinoma 10.5 ESR1 PGR
37 adrenal gland hyperfunction 10.5 HMGA1 HMGA2
38 pseudounicornuate uterus 10.5 IGF2 PGR
39 malignant hyperthermia susceptibility type 3 10.5 HMGA1 HMGA2
40 rhinoscleroma 10.4 COMT PRL
41 ovary rhabdomyosarcoma 10.4 HMGA1 HMGA2
42 superficial basal cell carcinoma 10.4 ESR1 PGR
43 sarcomatoid squamous cell skin carcinoma 10.4 ESR1 PGR
44 vertebral artery occlusion 10.4 GNRH1 PRL
45 uterine ligament clear cell adenocarcinoma 10.4 GNRH1 IGF1 PRL
46 adamantinous craniopharyngioma 10.4 GNRH1 IGF1 PRL
47 pineal region meningioma 10.4 ESR1 PGR
48 alpha-methylacyl-coa racemase deficiency 10.4 GNRH1 IGF1 PRL
49 organ system benign neoplasm 10.4 ESR1 MED12 PGR
50 cartilage cancer 10.4 ESR1 MED12 PGR

Comorbidity relations with Uterine Fibroid via Phenotypic Disease Network (PDN):


Asherman's Syndrome Cervix Uteri Carcinoma in Situ
Chronic Salpingo-Oophoritis Endometriosis
Endometriosis of Ovary Endometriosis of Uterus
Female Stress Incontinence Hemometra
Ovarian Cancer, Somatic Salpingo-Oophoritis

Graphical network of the top 20 diseases related to Uterine Fibroid:



Diseases related to Uterine Fibroid

Symptoms & Phenotypes for Uterine Fibroid

UMLS symptoms related to Uterine Fibroid:


pelvic pain

GenomeRNAi Phenotypes related to Uterine Fibroid according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 FH IGF2 RAD51B

MGI Mouse Phenotypes related to Uterine Fibroid:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 GNRH1 IGF1 IGF2 MMP2 PGR PRL
2 immune system MP:0005387 10.2 COMT CYP19A1 EGF ESR1 GNRH1 IGF1
3 cardiovascular system MP:0005385 10.16 MMP2 PGR TGFB3 COMT CYP19A1 ESR1
4 endocrine/exocrine gland MP:0005379 10.15 COMT CYP19A1 EGF ESR1 GNRH1 IGF1
5 integument MP:0010771 10.03 PRL CYP19A1 EGF ESR1 GNRH1 IGF1
6 nervous system MP:0003631 10.02 COMT CYP19A1 ESR1 GNRH1 IGF1 IGF2
7 normal MP:0002873 9.91 CYP19A1 EGF ESR1 GNRH1 IGF1 MED12
8 limbs/digits/tail MP:0005371 9.88 ESR1 IGF1 IGF2 MED12 PGR TGFB3
9 neoplasm MP:0002006 9.85 ESR1 GNRH1 IGF1 MMP2 PGR PRL
10 renal/urinary system MP:0005367 9.7 CYP19A1 ESR1 FH GNRH1 IGF1 IGF2
11 reproductive system MP:0005389 9.61 IGF2 PGR PRL COMT CYP19A1 EGF
12 skeleton MP:0005390 9.28 CYP19A1 ESR1 GNRH1 IGF1 IGF2 MED12

Drugs & Therapeutics for Uterine Fibroid

Drugs for Uterine Fibroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 253)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Dienogest Approved Phase 4 65928-58-7
3
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
4
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
5
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
6
Dimenhydrinate Approved Phase 4 523-87-5 441281
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Calcium Carbonate Approved Phase 4,Phase 3 471-34-1
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53714-56-0 3911 657181
10
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
11
Zinc Approved Phase 4 7440-66-6 32051 23994
12
Zinc oxide Approved Phase 4 1314-13-2
13
Ethanol Approved Phase 4 64-17-5 702
14
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Dinoprostone Approved Phase 4 363-24-6 5280360
21
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
22
Prilocaine Approved Phase 4 721-50-6 4906
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Remifentanil Approved Phase 4 132875-61-7 60815
25
Mifepristone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 84371-65-3 55245
26
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
27
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
28
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
30
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1 1197-18-8 5526
31
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
32
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
33
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
34
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
35
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
36
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
37
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
38
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
39
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
41
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
42
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
43
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
44
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
45
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
46
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
47
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
48 Tocopherol Approved, Nutraceutical Phase 4
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
50 tannic acid Approved, Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 313)

id Name Status NCT ID Phase Drugs
1 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
2 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
3 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4 Ambulatory Oxygen
4 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
5 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4 Dydrogesterone M ( case 1 );Dydrogesterone M ( case 2 )
6 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
7 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
8 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
9 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4 GnRH analogue (Zoladex);GnRH antagonist-Cetrorelix
10 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
11 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
12 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4 Lidocaine per-embolization;Lidocaine post-embolization
13 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;IV Placebo
14 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
15 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
16 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4 Vasopressin
17 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4 Normal saline;Intravenous Lidocaine;Intra-abdominal Lidocaine
18 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4 2 doses 400 microgram misoprostol;single dose misoprostol
19 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4 Remifentanil, propofol and citanest
20 A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy Recruiting NCT03210324 Phase 4 Mifepristone tablets
21 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Recruiting NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate
22 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Recruiting NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
23 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Recruiting NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
24 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4 Misoprostol;Placebo
25 Ulipristal Use in Chinese Population Recruiting NCT02825719 Phase 4 Ulipristal acetate;Ferrous sulphate;Tranexamic Acid
26 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Recruiting NCT02288130 Phase 4 GnRHa;Ulipristal
27 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Recruiting NCT02361892 Phase 4 ulipristal acetate
28 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4 Rocuronium
30 Uterine Leiomyoma Treatment With Radiofrequency Ablation Active, not recruiting NCT01840124 Phase 4
31 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Active, not recruiting NCT00995878 Phase 4
32 Pilot of Letrozole for Uterine Myomas Active, not recruiting NCT02470741 Phase 4 Letrozole
33 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
34 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Not yet recruiting NCT02601196 Phase 4 Ulipristal acetate
35 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Not yet recruiting NCT02440750 Phase 4 Dienogest;Ulipristal acetate
36 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Phase 4
37 Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids Terminated NCT01328067 Phase 4
38 Uterine Fibroid Pregnancy Registry Terminated NCT00232713 Phase 4
39 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4 pregabalin/celecoxib;pregabalin/placebo;celecoxib/placebo;Placebo group
40 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
41 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3 TSD
42 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
43 Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Unknown status NCT01715597 Phase 3 ascorbic acid
44 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
45 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
46 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
47 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
48 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
49 Mifepristone for Treatment of Uterine Fibroids Completed NCT00712595 Phase 2, Phase 3 Mifepristone;Mifepristone
50 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3

Search NIH Clinical Center for Uterine Fibroid

Genetic Tests for Uterine Fibroid

Genetic tests related to Uterine Fibroid:

id Genetic test Affiliating Genes
1 Uterine Leiomyoma 29

Anatomical Context for Uterine Fibroid

MalaCards organs/tissues related to Uterine Fibroid:

39
Uterus, Smooth Muscle, Testes, Prostate, Bone, Kidney, Endothelial

Publications for Uterine Fibroid

Articles related to Uterine Fibroid:

(show top 50) (show all 412)
id Title Authors Year
1
Changes in anti-mA1llerian hormone levels as a biomarker for ovarian reserve after ultrasound-guided high-intensity focused ultrasound treatment of adenomyosis and uterine fibroid. ( 28856867 )
2017
2
Recent Advances in Uterine Fibroid Etiology. ( 28278535 )
2017
3
Incarceration of a pedunculated uterine fibroid in an umbilical hernia. ( 28534020 )
2017
4
Translation and validation of the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire for the Brazilian Portuguese language. ( 28301630 )
2017
5
Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire. ( 27733082 )
2017
6
A case of disseminated peritoneal leiomyomatosis after two laparoscopic procedures due to uterine fibroids. ( 28446940 )
2017
7
A New Paradigm for Uterine Fibroid Treatment: Transcervical, Intrauterine Sonography-Guided Radiofrequency Ablation of Uterine Fibroids with the Sonata System. ( 28357157 )
2017
8
Fibroid vascularisation as a predictor for uterine fibroid growth. ( 28485851 )
2017
9
Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks' Gestation with Systematic Review of the Literature. ( 28523198 )
2017
10
Disability benefits as an incentive for hysterectomy: Uterine fibroid patients in Taiwan. ( 28816634 )
2017
11
Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. ( 28089575 )
2017
12
Spontaneous Pregnancy with a Live Birth after Conventional and Partial Uterine Fibroid Embolization. ( 28608747 )
2017
13
A randomized control trial to assess efficacy of Mifepristone in medical management of uterine fibroid. ( 28790785 )
2017
14
Effect of the degree of magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroid tissue on 6-month volume reduction. ( 28084010 )
2017
15
Ayurvedic Management of Recurrent Abortions due to Uterine Fibroid. ( 28867860 )
2017
16
The effect of exercise on high-intensity focused ultrasound treatment efficacy in uterine fibroids and adenomyosis: a retrospective study. ( 28856860 )
2017
17
Evaluation of Changes in Sexual Function Related to Uterine Fibroid Embolization (UFE): Results of the EFUZEN Study. ( 28321542 )
2017
18
Radiation Exposure During Uterine Fibroid Embolization (UFE): A Confounder-Controlled Comparison Between a State-of-the-Art Angiography Unit and a Conventional Angiography unit. ( 28934806 )
2017
19
Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery. ( 28400352 )
2017
20
Impact of uterine fibroid symptoms on health-related quality of life of US women: evidence from a cross-sectional survey. ( 28836862 )
2017
21
Radiation Dose Reduction during Uterine Fibroid Embolization Using an Optimized Imaging Platform. ( 28457758 )
2017
22
One year symptom severity and health-related quality of life changes among Black African patients undergoing uterine fibroid embolisation. ( 28676073 )
2017
23
Scaled Signal Intensity of Uterine Fibroids on T2-Weighted MR Imaging as a Predictor of the Potential Response to Uterine Fibroid Embolization. ( 28291713 )
2017
24
The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids. ( 26888970 )
2016
25
Herpes Simplex Virus Type 2 Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. ( 27188945 )
2016
26
Uterine fibroid characteristics and sonographic pattern among Ghanaian females undergoing pelvic ultrasound scan: a study at 3-major centres. ( 26884233 )
2016
27
Greater Cephalad Extent of Thoracic Epidural Sensory Anesthesia After Lidocaine and Epinephrine Test Dose Correlates With Analgesic Consumption and Pain Burden After Uterine Fibroid Artery Embolization. ( 26587675 )
2016
28
18F-FDG PET/CT Demonstrating Malignant Degeneration of a Uterine Fibroid. ( 27556790 )
2016
29
Spontaneous Pregnancy Following Ulipristal Acetate Treatment in a Woman with a Symptomatic Uterine Fibroid. ( 26872760 )
2016
30
Tunable delivery of niflumic acid from resorbable embolization microspheres for uterine fibroid embolization. ( 27374196 )
2016
31
The association between clinical parameters and uterine fibroid size in patients who underwent abdominal myomectomy. ( 28471125 )
2016
32
Converting of Myometrial Stem Cells to Tumor-Initiating Cells: Mechanism of Uterine Fibroid Development. ( 28042616 )
2016
33
Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation. ( 26973527 )
2016
34
Factors associated with uterine fibroid in Ghanaian women undergoing pelvic scans with suspected uterine fibroid. ( 28620536 )
2016
35
Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study. ( 27371355 )
2016
36
Vitamin D3 Inhibits Wnt/I^-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells. ( 26820714 )
2016
37
Uterine Fibroid (Leiomyoma) with Acute Urinary Retention: A Case Series. ( 27190903 )
2016
38
A Case of Pyomyoma following Uterine Fibroid Embolization and a Review of the Literature. ( 27066283 )
2016
39
Uterine fibroid management: from the present to the future. ( 27466209 )
2016
40
The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI. ( 27867814 )
2016
41
Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells. ( 27020169 )
2016
42
Lower Serum Levels of Uric Acid in Uterine Fibroids and Fibrocystic Breast Disease Patients in Dongying City, China. ( 27398332 )
2016
43
Expulsion of a Uterine Fibroid into the Small Bowel through Uteroenteric Fistula Presenting with Bowel Obstruction after Uterine Fibroid Embolization: Case Report with Histopathologic Correlation. ( 27106649 )
2016
44
Updates in uterine fibroid tissue extraction. ( 27253236 )
2016
45
Influence of vitamin D and transforming growth factor I^3 serum concentrations, obesity, and family history on the risk for uterine fibroids. ( 27743697 )
2016
46
Uterine fibroid embolization with acrylamido polyvinyl microspheres: prospective 12-month clinical and MRI follow-up study. ( 27872351 )
2016
47
Intravoxel incoherent motion diffusion-weighted imaging in differentiating uterine fibroid from focal adenomyosis: initial results. ( 26759748 )
2016
48
Hyperkalemia and acute kidney failure associated with preoperative uterine artery embolization for a large uterine fibroid: a case report. ( 27799061 )
2016
49
Risk of Occult Uterine Sarcoma in Presumed Uterine Fibroids. ( 26645385 )
2016
50
Degenerated uterine fibroid with rupture of the surface leading to haemoperitoneum. ( 27988218 )
2016

Variations for Uterine Fibroid

Copy number variations for Uterine Fibroid from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 70739 12 64503703 64646338 Duplication HMGA2 Uterine leiomyoma
2 230938 8 100959547 100975071 Translate COX6C Uterine leiomyoma

Expression for Uterine Fibroid

Search GEO for disease gene expression data for Uterine Fibroid.

Pathways for Uterine Fibroid

Pathways related to Uterine Fibroid according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 EGF ESR1 GNRH1 IGF1 IGF2 TGFB3
2
Show member pathways
12.45 EGF GNRH1 IGF1 IGF2 TGFB3
3 12.4 EGF FH IGF1 MMP2 TGFB3
4 12.09 ESR1 IGF1 IGF2 MMP2
5 11.75 EGF IGF1 IGF2
6 11.67 EGF IGF1 TGFB3
7
Show member pathways
11.49 EGF ESR1 PGR PRL
8 11.47 EGF IGF1 MMP2
9 11.42 IGF1 IGF2 MMP2
10
Show member pathways
11.4 EGF MMP2 TGFB3
11 11.34 EGF GNRH1 IGF1 IGF2 TGFB3
12 11.23 EGF IGF1 TGFB3
13
Show member pathways
10.55 EGF IGF1 IGF2
14 10.12 IGF1 IGF2 MMP2
15 9.92 CYP19A1 ESR1

GO Terms for Uterine Fibroid

Cellular components related to Uterine Fibroid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.96 HMGA1 HMGA2
2 platelet alpha granule lumen GO:0031093 8.92 EGF IGF1 IGF2 TGFB3

Biological processes related to Uterine Fibroid according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.98 ESR1 HMGA1 HMGA2 IGF1 MED12 PGR
2 cellular protein metabolic process GO:0044267 9.78 IGF1 IGF2 MMP2 PRL
3 phosphatidylinositol-mediated signaling GO:0048015 9.74 EGF IGF1 TNRC6B
4 activation of MAPK activity GO:0000187 9.73 EGF IGF1 TGFB3
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 EGF IGF1 IGF2
6 platelet degranulation GO:0002576 9.62 EGF IGF1 IGF2 TGFB3
7 mammary gland alveolus development GO:0060749 9.59 EGF ESR1
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.58 ESR1 MED12
9 androgen metabolic process GO:0008209 9.58 CYP19A1 ESR1
10 uterus development GO:0060065 9.55 CYP19A1 ESR1
11 positive regulation of glycogen biosynthetic process GO:0045725 9.54 IGF1 IGF2
12 positive regulation of transcription regulatory region DNA binding GO:2000679 9.52 HMGA2 IGF1
13 positive regulation of cellular senescence GO:2000774 9.49 HMGA1 HMGA2
14 embryonic neurocranium morphogenesis GO:0048702 9.46 MED12 TGFB3
15 senescence-associated heterochromatin focus assembly GO:0035986 9.4 HMGA1 HMGA2
16 mammary gland development GO:0030879 9.37 CYP19A1 TGFB3
17 positive regulation of mitotic nuclear division GO:0045840 9.33 EGF IGF1 IGF2
18 oncogene-induced cell senescence GO:0090402 9.26 HMGA1 HMGA2
19 female pregnancy GO:0007565 9.26 COMT GNRH1 PRL TGFB3
20 positive regulation of transcription, DNA-templated GO:0045893 9.17 EGF ESR1 HMGA1 HMGA2 IGF1 MED12

Molecular functions related to Uterine Fibroid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.71 ESR1 HMGA1 HMGA2 MED12
2 insulin-like growth factor receptor binding GO:0005159 9.37 IGF1 IGF2
3 DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 9.26 HMGA1 HMGA2
4 growth factor activity GO:0008083 9.26 EGF IGF1 IGF2 TGFB3
5 AT DNA binding GO:0003680 9.16 HMGA1 HMGA2
6 hormone activity GO:0005179 8.92 GNRH1 IGF1 IGF2 PRL
7 protein binding GO:0005515 10.2 COMT EGF ESR1 FH HMGA1 HMGA2

Sources for Uterine Fibroid

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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