MCID: UTR039
MIFTS: 49

Uterine Fibroid malady

Cancer diseases category

Summaries for Uterine Fibroid

About this section
Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Uterine fibroids are the most common benign tumors in women of childbearing age. fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. the cause of fibroids is unknown. risk factors include being african american or being overweight. many women with fibroids have no symptoms. if you do have symptoms, they may include heavy or painful periods or bleeding between periods feeling "full" in the lower abdomen urinating often pain during sex lower back pain reproductive problems, such as infertility, multiple miscarriages or early labor your health care provider may find fibroids during a gynecological exam or by using imaging tests. treatment includes drugs that can slow or stop their growth, or surgery. if you have no symptoms, you may not even need treatment. many women with fibroids can get pregnant naturally. for those who cannot, infertility treatments may help. nih: national institute of child health and human development

MalaCards: Uterine Fibroid, also known as plexiform leiomyoma, is related to leiomyoma and leiomyosarcoma. An important gene associated with Uterine Fibroid is FH (fumarate hydratase), and among its related pathways is Vitamin A and carotenoid metabolism. The compounds retinoic acid and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and testes.

Wikipedia:63 A uterine fibroid is a leiomyoma (benign tumor from smooth muscle tissue) that originates from the... more...

Description from OMIM:46 150699

Aliases & Classifications for Uterine Fibroid

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 46OMIM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

uterine fibroid 8 10
plexiform leiomyoma 8 60
uterine leiomyoma 8 44
uterine fibroids 33 60
leiomyoma of uterus, unspecified 8
leiomyoma of corpus uteri 8
uterine leiomyoma nos 8
uterus fibroma 8


External Ids:

Disease Ontology8 DOID:13223
NCIt39 C3434
ICD9CM27 218, 218.9
OMIM46 150699
MeSH34 D007889
ICD1025 D25.9

Related Diseases for Uterine Fibroid

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Uterine Fibroid:



Diseases related to uterine fibroid

Clinical Features for Uterine Fibroid

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

150699

Drugs & Therapeutics for Uterine Fibroid

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uterine Fibroid

Drug clinical trials:

Search ClinicalTrials for Uterine Fibroid

Search NIH Clinical Center for Uterine Fibroid

Search CenterWatch for Uterine Fibroid

Genetic Tests for Uterine Fibroid

About this section

Anatomical Context for Uterine Fibroid

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Uterine Fibroid:

32
Uterus, Smooth muscle, Testes, Kidney, Spleen, Endothelial, Cervix, Skin, Breast, Heart, Pituitary

Animal Models for Uterine Fibroid or affiliated genes

About this section

Publications for Uterine Fibroid

About this section
Sources:
50PubMed
See all sources

Articles related to Uterine Fibroid:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway. (23284171)
2013
2
The health disparities of uterine fibroid tumors for African American women: a public health issue. (23942040)
2013
3
Pathogenesis of endometriosis and uterine fibroids. (24379834)
2013
4
Self-report versus ultrasound measurement of uterine fibroid status. (22044079)
2012
5
Use of chinese medicine and subsequent surgery in women with uterine fibroid: a retrospective cohort study. (23118794)
2012
6
Uteroenteric fistula resulting from fibroid expulsion after uterine fibroid embolization: case report and review of the literature. (22159908)
2012
7
Utility of MRI before and after uterine fibroid embolization: why to do it and what to look for. (21085962)
2011
8
Development of an electronic daily uterine fibroid symptom diary. (21766892)
2011
9
HMGA proteins regulate the expression of FGF2 in uterine fibroids. (20926602)
2011
10
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. (21460842)
2011
11
Is gallium nitrate an effective kidney stone, calcified uterine fibroid, atherosclerosis and cataract anti-nanobacteria treatment? A case history and hypothesis. (19758769)
2010
12
Effect of timing, dose and interstitial versus nanoparticle delivery of tumor necrosis factor alpha in combinatorial adjuvant cryosurgery treatment of ELT-3 uterine fibroid tumor. (20309509)
2010
13
Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid. (21138652)
2010
14
Chronic uterine inversion secondary to submucous fibroid: a case report. (19562933)
2009
15
Incarceration of a sessile uterine fibroid in an umbilical hernia during pregnancy. (18998196)
2009
16
Life-threatening iron deficiency anemia and profound lactic acidosis due to uterine fibroid bleeding. (19328407)
2009
17
Uterine fibroid embolization. (19955532)
2009
18
Fatal nontarget embolization via an intrafibroid arterial venous fistula during uterine fibroid embolization. (19167246)
2009
19
Contrast-enhanced ultrasound (CEUS) assessment of superselective uterine fibroid embolization (SUFE): Preliminary experience(). (23396952)
2008
20
Huge uterine fibroid in a postmenopausal woman associated with polycythaemia: a case report. (18482807)
2008
21
The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids. (18752908)
2008
22
Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. (19075141)
2008
23
Uterine fibroid embolization: CME update for family physicians. (17872642)
2007
24
Possibilities to use the aromatase inhibitors for the treatment of the uterine fibroids]. (16649417)
2006
25
Degenerated uterine fibroid mimicking hydrometra: fallacy in CT. (21614328)
2006
26
Uterine fibroid ablation: the beginning of the end of uterine fibroid embolization? (16502182)
2006
27
The EMMY trial of uterine artery embolization for the treatment of symptomatic uterine fibroid tumors: randomized, yes, but a flawed trial nonetheless. (16567666)
2006
28
Uterine fibroid embolization. (17145478)
2006
29
Failure of uterine fibroid embolization. (16412722)
2006
30
SOGC clinical practice guidelines. Uterine fibroid embolization (UFE). Number 150, October 2004. (16001461)
2005
31
Ureteric obstruction requiring nephrectomy after uterine fibroid embolization. (15777494)
2005
32
Persistent vaginal discharge after uterine artery embolization for fibroid tumors: cause of the condition, magnetic resonance imaging appearance, and surgical treatment. (15167823)
2004
33
Uterine fibroid tumors: long-term MR imaging outcome after embolization. (14990844)
2004
34
Uterine fibroid embolization: is there a role? (15138541)
2004
35
The Ontario Uterine Fibroid Embolization Trial. Part 1. Baseline patient characteristics, fibroid burden, and impact on life. (12524073)
2003
36
Influence of information sources on the adoption of uterine fibroid embolization by interventional radiologists. (14566376)
2003
37
Technical results and effects of operator experience on uterine artery embolization for fibroids: the Ontario Uterine Fibroid Embolization Trial. (12761307)
2003
38
Treatment of uterine fibroid tumors in an in situ rat model using high-intensity focused ultrasound. (14505751)
2003
39
VI. Uterine fibroid embolization: developing a clinical service. (12098109)
2002
40
Intraperitoneal haemorrhage secondary to perforation of uterine fibroid after cystic degeneration. Unusual CT findings resembling malignant pelvic tumor: case report. (12556108)
2002
41
Uterine fibroid embolization. (11579772)
2001
42
Uterine fibroid embolization: assessment of treatment response using perfusion-weighted extraslice spin tagging (EST) magnetic resonance imaging. (11382963)
2001
43
A new twist on the Waltman loop for uterine fibroid embolization. (11487683)
2001
44
Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids. (11405968)
2001
45
Embolic agents used for uterine fibroid embolization. (10954464)
2000
46
Soft-tissue case 36. Ischemic necrosis of a large uterine fibroid after embolization. (11129827)
2000
47
Polycythemia associated with uterine fibroid. (7927586)
1994
48
Intraperitoneal haemorrhage from a vessel on the surface of a uterine fibroid. (13800627)
1960
49
The uterine fibroid. (12981386)
1952
50
A Venous Aneurysm on a Uterine Fibroid. (19973816)
1909

Genetic Variations for Uterine Fibroid

About this section

Expression for genes affiliated with Uterine Fibroid

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uterine Fibroid

Search GEO for disease gene expression data for Uterine Fibroid.

Pathways for genes affiliated with Uterine Fibroid

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Uterine Fibroid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5ADH1A, RBP1, CRABP2

Compounds for genes affiliated with Uterine Fibroid

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Uterine Fibroid according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.7ADH1A, GNRH1, TFAP2C, CRABP2, RBP1, MMP11
2vitamin a44 11 2412.7CRABP2, RBP1, PAEP, ADH1A
3retinoid4410.6ADH1A, RARRES3, RBP1, CRABP2
4progesterone44 59 28 11 2414.6GNRH1, RBP1, DUSP13, MMP11, PAEP
5nad+4410.6SIRT3, RBP1, FH
6steroid4410.5GNRH1, CRABP2, RBP1, MMP11, PAEP
7tibolone4410.5PAEP, GNRH1
8buserelin44 28 1112.4PAEP, GNRH1
9clomiphene citrate4410.2PAEP, GNRH1

GO Terms for genes affiliated with Uterine Fibroid

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Uterine Fibroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organismal developmentGO:00727510.5PAEP, MMP11, GNRH1, ODF3

Molecular functions related to Uterine Fibroid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol bindingGO:01984110.5RBP1, CRABP2
2retinoid bindingGO:00550110.4RBP1, CRABP2
3retinal bindingGO:01691810.2RBP1, CRABP2

Products for genes affiliated with Uterine Fibroid

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uterine Fibroid

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet