MCID: UTR054
MIFTS: 23

Uterine Hypoplasia

Categories: Reproductive diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Uterine Hypoplasia

Summaries for Uterine Hypoplasia

MalaCards based summary : Uterine Hypoplasia is related to ovarian dysgenesis 2 and ovarian dysgenesis 3. An important gene associated with Uterine Hypoplasia is BMP15 (Bone Morphogenetic Protein 15). The drugs Vitamin D and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone and cervix, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 Uterine hypoplasia, also known as naive uterus or infantile uterus, is a reproductive disorder... more...

Related Diseases for Uterine Hypoplasia

Diseases related to Uterine Hypoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ovarian dysgenesis 2 10.9
2 ovarian dysgenesis 3 10.9
3 ovarian dysgenesis 4 10.9
4 ovarian dysgenesis 5 10.9
5 46,xx sex reversal 1 9.7 BMP15 PSMC3IP
6 progesterone resistance 9.7
7 gonadal dysgenesis 9.7 BMP15 PSMC3IP
8 premature ovarian failure 1 9.3 BMP15 MCM9

Graphical network of the top 20 diseases related to Uterine Hypoplasia:



Diseases related to Uterine Hypoplasia

Symptoms & Phenotypes for Uterine Hypoplasia

MGI Mouse Phenotypes related to Uterine Hypoplasia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.13 BMP15 MCM9 PSMC3IP
2 reproductive system MP:0005389 8.8 BMP15 MCM9 PSMC3IP

Drugs & Therapeutics for Uterine Hypoplasia

Drugs for Uterine Hypoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
2
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
3 Micronutrients
4 Trace Elements
5 Vitamins
6 Ergocalciferols
7 Bone Density Conservation Agents
8 Vitamin D2 Nutraceutical
9 Calciferol Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Health-Related QoL Among Women Receiving Hysterectomy in NTUH Unknown status NCT00155870
2 Vitamin D Deficiency and Pregnancy Rates in Women Undergoing Frozen Embryo Transfer Completed NCT01985672
3 Vitamin D Deficiency and Ovarian Reserve Among Infertile Patients Completed NCT01999608

Search NIH Clinical Center for Uterine Hypoplasia

Genetic Tests for Uterine Hypoplasia

Anatomical Context for Uterine Hypoplasia

MalaCards organs/tissues related to Uterine Hypoplasia:

38
Uterus, Bone, Cervix

Publications for Uterine Hypoplasia

Articles related to Uterine Hypoplasia:

# Title Authors Year
1
Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. ( 15117941 )
2004
2
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. ( 9241280 )
1997
3
Case of the day. 7. Diagnosis: Turner's syndrome with uterine hypoplasia. ( 7933009 )
1994
4
Depot estrogen as a monthly contraceptive in nulliparous women with mild uterine hypoplasia. ( 5008627 )
1972
5
Treatment of uterine hypoplasia by estrogens. ( 14019915 )
1963
6
The treatment of uterine hypoplasia by provoking pseudopregnancy with new progestin preparations. ( 13770451 )
1961
7
Primary endometrial aplasia. Congenitial absence of the endometrium without associated endocrine dysfunction or uterine hypoplasia. ( 13688829 )
1961
8
A preliminary series of cases of uterine hypoplasia treated by local injection of an oestrogenic emulsion. ( 14368390 )
1955

Variations for Uterine Hypoplasia

Expression for Uterine Hypoplasia

Search GEO for disease gene expression data for Uterine Hypoplasia.

Pathways for Uterine Hypoplasia

GO Terms for Uterine Hypoplasia

Biological processes related to Uterine Hypoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female gamete generation GO:0007292 8.62 BMP15 MCM9

Sources for Uterine Hypoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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