MCID: UTR020
MIFTS: 35

Uterine Inversion malady

Categories: Reproductive diseases

Aliases & Classifications for Uterine Inversion

Aliases & Descriptions for Uterine Inversion:

Name: Uterine Inversion 12 42 14 69
Inversion of Uterus During Delivery 69

Classifications:



External Ids:

Disease Ontology 12 DOID:997
ICD10 33 N85.5
ICD9CM 35 665.2
MeSH 42 D019687
UMLS 69 C0162482

Summaries for Uterine Inversion

MalaCards based summary : Uterine Inversion, also known as inversion of uterus during delivery, is related to mucoepidermoid thyroid carcinoma and iritis. An important gene associated with Uterine Inversion is FEZF1 (FEZ Family Zinc Finger 1), and among its related pathways/superpathways are Cardiac Progenitor Differentiation and Differentiation Pathway. The drugs Kaolin and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and cervix, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 71 Uterine inversion is a potentially fatal childbirth complication with a maternal survival rate of about... more...

Related Diseases for Uterine Inversion

Diseases related to Uterine Inversion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
id Related Disease Score Top Affiliating Genes
1 mucoepidermoid thyroid carcinoma 10.2 FEZF1 FEZF2
2 iritis 10.1 FEZF1 FEZF2
3 ascending colon cancer 10.1 FEZF1 FEZF2
4 sarcoma 10.1
5 bile duct carcinoma 10.1 FEZF1 FEZF2
6 uterine sarcoma 10.1
7 vaginitis 10.0
8 familial hyperaldosteronism 10.0 CSF1R KIT
9 hepatic angiomyolipoma 10.0 FEZF1 FEZF2
10 leiomyoma 10.0
11 adducted thumbs dundar type 10.0 CSF1R KIT
12 myoma 9.9
13 vaginal yolk sac tumor 9.9 F7 KCNJ11 KIT
14 retroperitoneal leiomyosarcoma 9.9 F7 KCNJ11 KIT
15 teratoma 9.8
16 cardiac arrest 9.8
17 cervicitis 9.8
18 rhabdomyosarcoma 9.8
19 placenta accreta 9.7
20 embryonal rhabdomyosarcoma 9.7
21 endometrial cancer 9.6
22 thrombosis 9.6
23 mucositis 9.6
24 eosinophilia-myalgia syndrome 8.7 CSF1R F7 FEZF1 FEZF2 KCNJ11 KIT

Graphical network of the top 20 diseases related to Uterine Inversion:



Diseases related to Uterine Inversion

Symptoms & Phenotypes for Uterine Inversion

MGI Mouse Phenotypes related to Uterine Inversion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 CSF1R F7 FEZF1 FEZF2 KCNJ11 KIT
2 mortality/aging MP:0010768 9.81 FEZF1 FEZF2 KCNJ11 KIT MIXL1 OXT
3 craniofacial MP:0005382 9.72 CSF1R F7 FEZF1 FEZF2 KIT
4 no phenotypic analysis MP:0003012 9.35 CSF1R F7 KCNJ11 KIT MIXL1
5 taste/olfaction MP:0005394 8.8 CSF1R FEZF1 FEZF2

Drugs & Therapeutics for Uterine Inversion

Drugs for Uterine Inversion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Kaolin Approved 1332-58-7
2
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
3 Oxytocics
4 Pharmaceutical Solutions
5 Citrate Nutraceutical
6
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:


id Name Status NCT ID Phase
1 Controlled Cord Traction During Third Stage of Labor Completed NCT00781066 Phase 3
2 Prevention of Post-partum Haemorrhage Completed NCT01044082
3 In-vitro Study to Assess the Coagulation Effects of Exogenous Oxytocin Using Thromboelastography. Completed NCT00788255
4 The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta Recruiting NCT02590484
5 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Uterine Inversion

Cochrane evidence based reviews: uterine inversion

Genetic Tests for Uterine Inversion

Anatomical Context for Uterine Inversion

MalaCards organs/tissues related to Uterine Inversion:

39
Uterus, Placenta, Cervix, Ovary

Publications for Uterine Inversion

Articles related to Uterine Inversion:

(show top 50) (show all 220)
id Title Authors Year
1
Successful use of a Bakri Tamponade Balloon in the treatment of puerperal uterine inversion during caesarean section. ( 27118473 )
2016
2
Chronic Uterine Inversion Presenting as a Painless Vaginal Mass at 6 Months Post Partum: A Case Report. ( 27437313 )
2016
3
Upside-Down and Inside-Out Signs in Uterine Inversion. ( 27298665 )
2016
4
Color Doppler examination for the diagnosis of subacute puerperal uterine inversion. ( 27245667 )
2016
5
Acute complete uterine inversion after controlled cord traction of placenta following vaginal delivery: a case report. ( 27386133 )
2016
6
Puerperal uterine inversion managed by the uterine balloon tamponade. ( 26977239 )
2015
7
Chronic total uterine inversion in an adolescent. ( 26576285 )
2015
8
The Importance of the Monitoring of Resuscitation with Blood Transfusion for Uterine Inversion in Obstetrical Hemorrhage. ( 26491450 )
2015
9
Intrauterine tamponade balloon use in the treatment of uterine inversion. ( 25564634 )
2015
10
Uterine inversion after an unskilled delivery - still a concern for maternal mortality: A case report and discussion of the related medico-legal issues. ( 26232213 )
2015
11
Uterus Preserving Reposition of Non-Puerperal Uterine Inversion under Laparoscope: A Case Report and Literature Review. ( 25634558 )
2015
12
Chronic Total Uterine Inversion in a Young Adult Patient. ( 26494120 )
2015
13
Successful reduction of acute puerperal uterine inversion with the use of a bakri postpartum balloon. ( 25954560 )
2015
14
Uterine Balloon Tamponade Device and Cervical Cerclage to Correct Partial Uterine Inversion during Puerperium; Case Report. ( 25633203 )
2015
15
Magnetic Resonance Imaging of Non-Puerperal Complete Uterine Inversion. ( 26715983 )
2015
16
Non-puerperal uterine inversion in a patient with intracranial sigmoid sinus thrombosis and facial palsy. ( 25969481 )
2015
17
Laparoscopic View of a Case of Incomplete Uterine Inversion After Vaginal Delivery. ( 27679099 )
2015
18
Pulse contour analysis guided management of a case of puerperal uterine inversion and hemorrhagic shock - 'Giving what it takes'. ( 26265875 )
2015
19
Sonographic diagnosis of complete uterine inversion: an unusual case. ( 26054129 )
2015
20
Cardiac arrest following acute puerperal uterine inversion. ( 25694631 )
2015
21
Non-puerperal uterine inversion in a young woman: a case report. ( 27830135 )
2015
22
Chronic non puerperal uterine inversion secondary to sub-mucosal fibroid. ( 25272552 )
2014
23
Uterine inversion after controlled cord traction during caesarean section: a case report. ( 25134305 )
2014
24
Sonographic and MR features of puerperal uterine inversion. ( 24619161 )
2014
25
Total and acute uterine inversion after delivery: a case report. ( 25326075 )
2014
26
Immature uterine teratoma associated with uterine inversion. ( 25276328 )
2014
27
Complete chronic uterine inversion with eventration of the vagina. ( 24767659 )
2014
28
Kissing of Ovaries: Laparoscopic View of Uterine Inversion After Vaginal Delivery With Postpartum Hemorrhage. ( 25433278 )
2014
29
Postpartum prolapsed leiomyoma with uterine inversion managed by vaginal hysterectomy. ( 25379314 )
2014
30
Fatal postpartum air embolism due to uterine inversion and atonic hemorrhage. ( 23370575 )
2014
31
A Rare Case of Non-puerperal Acute Uterine Inversion. ( 25368463 )
2014
32
Acute uterine inversion: a simple modification of hydrostatic method of treatment. ( 24761250 )
2014
33
Totally inverted cervix due to a huge prolapsed cervical myoma simulating chronic non-puerperal uterine inversion. ( 24997386 )
2014
34
Non puerperal uterine inversion in a young female- a case report. ( 25386493 )
2014
35
Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. ( 24127992 )
2013
36
"Holding the cervix" technique: prophylaxis for acute recurrent uterine inversion. ( 23400358 )
2013
37
Acute puerperal uterine inversion. ( 24356804 )
2013
38
Complete acute uterine inversion. ( 24570794 )
2013
39
Uterine leiomyoma associated non-puerperal uterine inversion misdiagnosed as advanced cervical cancer: A case report. ( 24091076 )
2013
40
Sonographic findings in acute uterine inversion. ( 23339051 )
2013
41
Non-invasive management of acute recurrent puerperal uterine inversion with Bakri postpartum balloon. ( 23974277 )
2013
42
A case of acute on chronic uterine inversion with fibroid polyp. ( 24392411 )
2013
43
Puerperal uterine inversion in the Netherlands: a nationwide cohort study. ( 22881867 )
2013
44
MY (Matsubara-Yano) uterine compression suture to prevent acute recurrence of uterine inversion. ( 22881712 )
2013
45
Non-puerperal uterine inversion caused by malignant mixed mullerian sarcoma. ( 24334469 )
2013
46
Vaginal mass: myoma or uterine inversion or both? ( 23827689 )
2013
47
Ultrasound diagnosis of complete uterine inversion in a nulliparous woman. ( 22122794 )
2012
48
Uterine compression suture for acute recurrence of puerperal uterine inversion: Hayman suture? ( 22691274 )
2012
49
Uterine inversion in association with uterine sarcoma: a case report with MRI findings and review of the literature. ( 22377482 )
2012
50
Complete uterine inversion in a patient with endometrial cancer. ( 22742476 )
2012

Variations for Uterine Inversion

Expression for Uterine Inversion

Search GEO for disease gene expression data for Uterine Inversion.

Pathways for Uterine Inversion

Pathways related to Uterine Inversion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.68 KIT MIXL1
2 10.3 CSF1R KIT

GO Terms for Uterine Inversion

Biological processes related to Uterine Inversion according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.54 CSF1R FEZF1 FEZF2
2 positive regulation of cell migration GO:0030335 9.5 CSF1R F7 KIT
3 forebrain development GO:0030900 9.49 FEZF1 FEZF2
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 CSF1R KIT
5 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.46 CSF1R KIT
6 digestive tract development GO:0048565 9.43 KIT MIXL1
7 telencephalon development GO:0021537 9.4 FEZF1 FEZF2
8 response to estradiol GO:0032355 9.33 F7 KCNJ11 OXT
9 olfactory bulb development GO:0021772 9.26 CSF1R FEZF1
10 hemopoiesis GO:0030097 9.13 CSF1R KIT MIXL1
11 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Molecular functions related to Uterine Inversion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.33 FEZF1 FEZF2 MIXL1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 CSF1R KIT
3 cytokine binding GO:0019955 8.62 CSF1R KIT

Sources for Uterine Inversion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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