MCID: UTR043
MIFTS: 41

Uterine Sarcoma malady

Cancer diseases category

Summaries for Uterine Sarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 The uterine sarcomas form a group of malignant tumors that arises from the smooth muscle or connective... more...

MalaCards: Uterine Sarcoma, also known as uterine corpus sarcoma, is related to sarcoma and leiomyoma. An important gene associated with Uterine Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Estrogen biosynthesis and Osteoblast Signaling. The compounds Pazopanib and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include uterus and smooth muscle, and related mouse phenotypes are embryogenesis and hearing/vestibular/ear.

Aliases & Classifications for Uterine Sarcoma

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60UMLS, 42NIH Rare Diseases, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

uterine sarcoma 42 44
uterine corpus sarcoma 60
sarcoma of the uterus 42


Related Diseases for Uterine Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Uterine Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7PDGFRB, MKI67, KIT, TWIST1, SMARCB1, ABCB1
2leiomyoma30.6TYMP, CYP19A1, MME, KIT, ESR1, PDGFRA
3uterine carcinosarcoma30.5KIT
4alveolar soft part sarcoma30.5MB, DES
5peritonitis30.2MB
6synovial sarcoma30.2MDM2, KIT, MKI67, DES
7breast cancer30.2CSF1, TYMP, CYP19A1, ESR1
8endometrial stromal sarcoma30.2CSF1, PDGFRA, PDGFRB, DES, CYP19A1, MME
9myoma29.9CYP19A1, ESR1
10meningioma29.9ESR1, MKI67
11adenosarcoma29.9MB, MME, ESR1, DES
12cervical cancer29.9CSF1R, ABCB1, TYMP, MDM2
13adenocarcinoma29.9PDGFRB, CSF1R, WT1, MDM2, DCK, MKI67
14leiomyosarcoma29.9DCK, SMARCB1, KIT, MME, CAPN6, PDGFRB
15uterine inversion10.5
16uterine corpus sarcoma10.4
17mast-cell sarcoma10.3
18myeloid sarcoma10.3
19breast sarcoma10.2
20uterus leiomyosarcoma10.2
21cellular leiomyoma10.1
22endometrial stromal tumor10.1
23vaginitis10.1
24germ cell tumors10.0KIT
25glomerulonephritis10.0MME
26dermatofibrosarcoma10.0MDM2
27ductal carcinoma in situ10.0ESR1
28cholangiocarcinoma10.0MME
29angiosarcoma10.0PDGFRA
30nephroblastoma10.0WT1
31cystadenoma10.0MME
32sertoli-leydig cell tumor10.0WT1
33alzheimer's disease10.0MME
34gliosarcoma10.0PDGFRB
35hypertension10.0MME
36hepatitis10.0TYMP
37adenoma10.0MKI67
38retroperitoneal leiomyosarcoma10.0SMARCB1
39systemic mastocytosis10.0PDGFRB
40rhabdoid cancer10.0SMARCB1
41choroid plexus carcinoma10.0SMARCB1
42leydig cell tumor10.0PDGFRB, CYP19A1
43neurofibromatosis10.0PDGFRA
44congenital mesoblastic nephroma10.0SMARCB1
45chondroma10.0PDGFRA
46tuberous sclerosis10.0PDGFRB
47arteriosclerosis10.0PDGFRA
48sertoli cell tumor10.0CYP19A1, DES
49pleomorphic liposarcoma10.0MDM2, KIT
50infertility10.0CYP19A1, ESR1

Graphical network of the top 20 diseases related to Uterine Sarcoma:



Diseases related to uterine sarcoma

Clinical Features for Uterine Sarcoma

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Drugs & Therapeutics for Uterine Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Uterine Sarcoma

Drug clinical trials:

Search ClinicalTrials for Uterine Sarcoma

Search NIH Clinical Center for Uterine Sarcoma

Search CenterWatch for Uterine Sarcoma

Genetic Tests for Uterine Sarcoma

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Anatomical Context for Uterine Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Uterine Sarcoma:

32
Uterus, Smooth muscle

Animal Models for Uterine Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Uterine Sarcoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.4TWIST1, MB
2MP:000537710.3CSF1
3MP:000537110.2CSF1R, CSF1
4MP:001077110.0MME, MDM2, CSF1R, PDGFRA
5MP:000538910.0PDGFRA, CSF1, WT1, ABCB1
6MP:00053909.8PDGFRA, CSF1R, CSF1, CYP19A1, TWIST1
7MP:00036319.8CSF1, TYMP, CYP19A1, ABCB1, KIT
8MP:00030129.7CSF1, WT1, MDM2, KIT
9MP:00053769.6PDGFRB, PDGFRA, MB, CSF1, DES, ESR1
10MP:00053799.4PDGFRB, PDGFRA, CSF1R, CSF1, WT1, KIT
11MP:00053829.4PDGFRB, PDGFRA, CSF1R, CSF1, MDM2, KIT
12MP:00053699.3PDGFRB, PDGFRA, MB, CSF1, WT1, MDM2
13MP:00053709.3CSF1, WT1, MDM2, CYP19A1, MME, ABCB1
14MP:00053819.1PDGFRB, PDGFRA, MDM2, KIT, ESR1, TWIST1
15MP:00053869.0PDGFRA, CSF1R, CSF1, MDM2, DES, CYP19A1
16MP:00053858.7PDGFRB, PDGFRA, MB, CSF1, WT1, MDM2
17MP:00053788.7CSF1, CSF1R, MB, PDGFRA, PDGFRB, WT1
18MP:00053978.7CSF1, CSF1R, MB, PDGFRA, PDGFRB, WT1
19MP:00107688.6CSF1, CSF1R, MB, PDGFRA, PDGFRB, WT1
20MP:00053878.5MDM2, WT1, CSF1, CSF1R, PDGFRA, PDGFRB
21MP:00053848.3SMARCB1, PDGFRB, PDGFRA, MB, CSF1R, CSF1

Publications for Uterine Sarcoma

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Genetic Variations for Uterine Sarcoma

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Expression for genes affiliated with Uterine Sarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uterine Sarcoma

Search GEO for disease gene expression data for Uterine Sarcoma.

Pathways for genes affiliated with Uterine Sarcoma

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 52R&D Systems, 4Cell Signaling Technology, 29KEGG, 59Tocris Bioscience
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Pathways related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ESR1, CYP19A1
210.2PDGFRA, PDGFRB
3
Hide members
10.1LMTK3, CSF1R
410.0ESR1, ABCB1, MME
5
Hide members
10.0KIT, PDGFRA, PDGFRB
610.0PDGFRB, PDGFRA, MDM2
710.0MDM2, PDGFRA, PDGFRB
810.0KIT, CSF1R, PDGFRA
9
Hide members
10.0ESR1, LMTK3, PDGFRA
1010.0PDGFRB, PDGFRA, TYMP
119.9PDGFRB, CSF1R, CSF1
129.9CSF1, CSF1R, PDGFRB
13
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9.9PDGFRB, PDGFRA, MDM2, KIT
14
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9.9PDGFRB, PDGFRA, MDM2, KIT
159.9ABCB1, MDM2, PDGFRA, PDGFRB
16
Hide members
9.9PDGFRB, PDGFRA, LMTK3, KIT
17
Hide members
9.9PDGFRB, PDGFRA, LMTK3, KIT
189.8PDGFRA, CSF1R, MDM2, KIT
19
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9.8PDGFRB, PDGFRA, MDM2, TYMP
209.8CSF1R, CSF1, MME, KIT
21
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9.8CAPN6, PDGFRB, PDGFRA, MDM2
22
Hide members
9.7PDGFRB, PDGFRA, MDM2, KIT, ESR1
239.7KIT, MDM2, CSF1R, PDGFRA, PDGFRB
24
Hide members
9.7PDGFRB, PDGFRA, CSF1R, LMTK3, KIT
259.7PDGFRA, WT1, MDM2, ABCB1, ESR1
26
Hide members
9.5PDGFRB, PDGFRA, CSF1R, LMTK3, KIT, ESR1
279.5PDGFRB, PDGFRA, CSF1R, CSF1, MDM2, KIT
28
Hide members
9.3PDGFRB, PDGFRA, CSF1R, CSF1, MDM2, LMTK3
29
Hide members
9.3PDGFRB, PDGFRA, CSF1R, CSF1, LMTK3, KIT
30
Hide members
8.8ESR1, CAPN6, PDGFRB, PDGFRA, CSF1R, CSF1

Compounds for genes affiliated with Uterine Sarcoma

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Sources:
11DrugBank, 44Novoseek, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1Pazopanib1110.2PDGFRB, KIT, PDGFRA, ABCB1
2Regorafenib1110.2KIT, PDGFRB, PDGFRA, ABCB1
3cycloheximide4410.2MME, DCK, CSF1R, TYMP
4taxane4410.2TYMP, ESR1, ABCB1, CYP19A1
5capecitabine44 49 1112.2PDGFRB, KIT, ABCB1, CYP19A1, TYMP
6sunitinib44 49 1112.1PDGFRA, PDGFRB, ABCB1, KIT, CSF1R
7gefitinib44 49 1112.0MDM2, CYP19A1, ABCB1, KIT, ESR1, PDGFRB
8pkc 4124410.0PDGFRB, PDGFRA, KIT
9clomifene49 1111.0CYP19A1, ABCB1, ESR1
10gemcitabine44 49 1112.0CYP19A1, TYMP, ABCB1, PDGFRB, DCK
11erlotinib44 49 1112.0PDGFRB, TYMP, KIT, ABCB1
12vinorelbine44 1111.0DCK, TYMP, CYP19A1, MKI67, ABCB1
13diethylstilbestrol44 28 1112.0ESR1, ABCB1, CYP19A1, MDM2
14hydroxyurea44 49 1111.9DCK, KIT, MB, CSF1, PDGFRA
15adriamycin449.9ABCB1, MB, MDM2, DES, MME
16ifosfamide44 1110.9CSF1, MDM2, DCK, TYMP
17mifepristone44 59 28 1112.9CSF1R, MKI67, CYP19A1, ESR1, ABCB1
18p002449.9MDM2, DES, MKI67, TYMP, KIT
19mitomycin c449.9ABCB1, TYMP, MKI67, MDM2, DCK
20cytarabine44 49 1111.9DCK, KIT, ABCB1, MME, CSF1, CSF1R
21docetaxel44 49 59 1112.9KIT, ESR1, ABCB1, CYP19A1, TYMP, MDM2
22irinotecan44 49 1111.9KIT, MDM2, DCK, MKI67, TYMP, ABCB1
23p003449.9CSF1, MDM2, MKI67, TYMP, KIT
24thymidylate449.8MDM2, ABCB1, TYMP, MKI67, DCK
25serine449.7MB, CSF1R, WT1, DES, MKI67, CSF1
26etoposide44 49 59 1112.7CSF1R, CSF1, WT1, MDM2, DCK, ABCB1
27vincristine44 49 1111.7TYMP, WT1, MDM2, DCK, MKI67, KIT
28estradiol44 11 2411.7TYMP, CYP19A1, ABCB1, ESR1, MKI67, DES
2912-o-tetradecanoylphorbol 13-acetate449.6TYMP, MME, DES, WT1, CSF1, CSF1R
30actinomycin d449.6CSF1, MDM2, MME, TYMP, DES, ESR1
31paclitaxel44 49 1111.6ESR1, ABCB1, CYP19A1, TYMP, DCK, MDM2
32methotrexate44 49 1111.6ESR1, MDM2, KIT, ABCB1, CYP19A1, TYMP
33steroid449.6WT1, CSF1R, MME, CYP19A1, ESR1, DES
34cisplatin44 49 59 1112.5ABCB1, MKI67, MDM2, CSF1, PDGFRB, MB
35formaldehyde44 2410.5KIT, DES, MKI67, TYMP, CYP19A1
36cyclophosphamide44 49 1111.5DCK, CSF1, MDM2, MKI67, TYMP, CYP19A1
37progestins449.4MKI67, CSF1R, CYP19A1, ESR1
38oxygen44 2410.4MDM2, DES, MKI67, PDGFRB, TYMP, CYP19A1
39arginine449.4DES, MDM2, CYP19A1, MKI67, MB, CSF1
40imatinib44 49 1111.3PDGFRB, PDGFRA, CSF1R, CSF1, WT1, MDM2
41cysteine449.3MB, MME, CSF1R, CSF1, WT1, MDM2
425fluorouracil449.3ESR1, KIT, ABCB1, CYP19A1, TYMP, MKI67
43thymidine44 2410.2PDGFRA, KIT, MDM2, WT1, CSF1, DCK
44retinoic acid44 2410.0PDGFRB, PDGFRA, CSF1R, WT1, DES, MKI67
45testosterone44 59 11 2412.0ESR1, PDGFRB, MB, KIT, ABCB1, MME
46doxorubicin44 49 1111.0CYP19A1, MDM2, WT1, CSF1, MB, DES
47progesterone44 59 28 11 2412.8PDGFRB, CSF1R, WT1, MDM2, DES, TYMP
48paraffin448.8CSF1, CSF1R, MB, PDGFRA, PDGFRB, WT1
49vegf448.8PDGFRA, WT1, MB, CSF1R, CSF1, MDM2
50tyrosine448.5CSF1R, MKI67, PDGFRB, TWIST1, KIT, LMTK3

GO Terms for genes affiliated with Uterine Sarcoma

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16Gene Ontology
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Cellular components related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to plasma membraneGO:03122610.2PDGFRA, PDGFRB

Biological processes related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRB, PDGFRA
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.5PDGFRB, PDGFRA
3metanephric S-shaped body morphogenesisGO:07228410.5PDGFRB, WT1
4pyrimidine nucleotide metabolic processGO:00622010.4DCK, TYMP
5cell chemotaxisGO:06032610.4PDGFRB, PDGFRA, KIT
6metanephric mesenchyme developmentGO:07207510.4WT1, PDGFRB
7retina vasculature development in camera-type eyeGO:06129810.4PDGFRB, PDGFRA
8positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.4PDGFRB, PDGFRA, KIT
9adrenal gland developmentGO:03032510.3WT1, PDGFRA, PDGFRB
10phosphatidylinositol metabolic processGO:04648810.3PDGFRB, CSF1R
11positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.3KIT, PDGFRA, PDGFRB
12positive regulation of cell motilityGO:200014710.3CSF1R, TWIST1
13regulation of actin cytoskeleton reorganizationGO:200024910.3PDGFRA, CSF1R
14positive regulation of phospholipase C activityGO:01086310.3ESR1, KIT, PDGFRA, PDGFRB
15pyrimidine nucleoside salvageGO:04309710.3DCK, TYMP
16peptidyl-tyrosine phosphorylationGO:01810810.2KIT, CSF1R, PDGFRA, PDGFRB
17fibroblast growth factor receptor signaling pathwayGO:00854310.2KIT, MDM2, PDGFRA, PDGFRB
18hemopoiesisGO:03009710.2KIT, CSF1, CSF1R
19positive regulation of gene expressionGO:01062810.2CSF1, MDM2, KIT, TWIST1
20Fc-epsilon receptor signaling pathwayGO:03809510.2KIT, MDM2, PDGFRA, PDGFRB
21epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFRB, PDGFRA, MDM2, KIT
22protein autophosphorylationGO:04677710.2KIT, CSF1R, PDGFRA, PDGFRB
23cardiac myofibril assemblyGO:05500310.2PDGFRB, PDGFRA
24phosphatidylinositol-mediated signalingGO:04801510.1PDGFRB, PDGFRA, CSF1R, MDM2, KIT
25positive regulation of cell migrationGO:03033510.1CSF1, CSF1R, PDGFRA, PDGFRB
26positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1KIT, ESR1, SMARCB1
27male gonad developmentGO:00858410.1WT1, KIT, ESR1
28negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.1MDM2, TWIST1
29positive regulation of ERK1 and ERK2 cascadeGO:07037410.0CSF1R, PDGFRA, PDGFRB
30positive regulation of cell proliferationGO:0082849.9PDGFRB, PDGFRA, CSF1R, CSF1, MDM2, KIT
31innate immune responseGO:0450879.8PDGFRB, PDGFRA, CSF1R, CSF1, MDM2, KIT
32neurotrophin TRK receptor signaling pathwayGO:0480119.6KIT, MDM2, PDGFRA, PDGFRB

Molecular functions related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.2PDGFRA, PDGFRB
2protein tyrosine kinase activityGO:00471310.1KIT, LMTK3, PDGFRB
3platelet-derived growth factor receptor bindingGO:00516110.1TYMP, PDGFRA, PDGFRB
4platelet-derived growth factor bindingGO:0484079.9PDGFRA, PDGFRB
5protein homodimerization activityGO:0428039.5PDGFRA, CSF1R, CSF1, DCK, KIT, TWIST1
6ATP bindingGO:0055249.0PDGFRB, PDGFRA, CSF1R, DCK, MKI67, ABCB1

Products for genes affiliated with Uterine Sarcoma

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  • Antibodies
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Sources for Uterine Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet