Uterine Sarcoma malady

Wikipedia: A uterine sarcoma is a malignant tumor that arises from the smooth muscle or connective tissue of the...⁴⁴ more...

MalaCards: Uterine Sarcoma, also known as uterine corpus sarcoma, is related to endometrial stromal sarcoma and myoma. An important gene associated with Uterine Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Transcription P53 signaling pathway. The compounds cyclophosphamide and vincristine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

uterine sarcoma 30 32 uterine corpus sarcoma 43

sarcoma of the uterus 30

Diseases related to uterine sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 447)

id	Related Disease	Score	Top Affiliating Genes
1	endometrial stromal sarcoma	33.1	KIT, MME, ESR1, CYP19A1, PDGFRA, PDGFRB
2	myoma	28.0	ESR1, TERT, CYP19A1, TYMP, DES
3	leiomyoma	24.4	KIT, MYC, CDK2, CDKN2A, CDKN3, MME
4	sarcoma	23.8	KIT, LMTK3, MYC, KDR, CDK2, CDKN2A
5	wilms tumor	23.3	MYC, CDKN2A, MME, FLT1, MB, ESR1
6	peritonitis	20.6	KIT, KDR, CDK2, CDKN2A, CDKN3, MLH1
7	meninges sarcoma	13.7	MB, DES
8	pleomorphic liposarcoma	13.7	KIT, MDM2
9	mixed epithelial stromal tumour	13.6	MME, CYP19A1, DES
10	uterine disease	13.6	ESR1, CYP19A1
11	benign metastasizing leiomyoma	13.6	ESR1, CYP19A1, DES
12	gastrointestinal stromal tumor, somatic	13.6	KIT, PDGFRA
13	retroperitoneal leiomyosarcoma	13.6	KIT, SMARCB1, DES
14	pleomorphic rhabdomyosarcoma	13.6	MME, MB, DES
15	childhood mediastinal neurogenic tumor	13.6	WT1, DES
16	cribriform carcinoma	13.6	KIT, ESR1
17	rhabdoid cancer	13.6	MB, SMARCB1, DES
18	gastric leiomyosarcoma	13.6	PDGFRA, DES
19	ovarian sex cord tumors	13.5	MME, CYP19A1, DES
20	vulvovaginitis	13.5	KIT, ESR1, DES
21	carney triad	13.5	KIT, PDGFRA, DES
22	orbit rhabdomyosarcoma	13.5	MDM2, MB, ABCB1, DES
23	cystic nephroma	13.5	MME, WT1, DES
24	mesoblastic nephroma	13.5	KIT, WT1
25	desmoplastic small round cell tumor	13.5	WT1, DES
26	breast malignant phyllodes tumor	13.5	KIT, MME, MKI67
27	orbit embryonal rhabdomyosarcoma	13.5	MB, WT1, DES
28	chondroma	13.5	KIT, MDM2, PDGFRA
29	rhabdoid tumors	13.5	SMARCB1, WT1, DES
30	eosinophilic myeloproliferative disorder	13.5	PDGFRA, PDGFRB
31	congenital mesoblastic nephroma	13.5	MDM2, SMARCB1, WT1
32	acute megakaryoblastic leukemia	13.5	KIT, ABCB1, CSF1R
33	choroid plexus carcinoma	13.5	SMARCB1, PDGFRA, PDGFRB
34	sertoli cell tumor	13.4	KIT, CYP19A1, WT1, DES
35	pigmented villonodular synovitis	13.4	PDGFRB, CSF1, CSF1R
36	embryonal sarcoma	13.4	KIT, MKI67, MDM2, DES
37	pancreatic mucinous cystadenoma	13.4	KIT, MME
38	sertoli-leydig cell tumor	13.4	ESR1, CYP19A1, WT1, DES
39	acute myeloid leukemia, adult	13.4	KIT, WT1, ABCB1, DCK
40	synovial sarcoma	13.4	KIT, MKI67, MDM2, DES
41	pyloric stenosis	13.4	WT1, TYMP, DES
42	perivascular epithelioid cell tumor	13.4	KIT, CDKN2A, DES
43	estrogen resistance	13.4	ESR1, CYP19A1, PDGFRA
44	bannayan-riley-ruvalcaba syndrome	13.3	CDKN3, PTEN
45	megakaryoblastic leukemia	13.3	KIT, ESR1, ABCB1, CSF1R
46	sm-ahnmd	13.3	KIT, PDGFRA, PDGFRB
47	cryptorchidism	13.3	ESR1, CYP19A1, WT1, DES
48	pleomorphic xanthoastrocytoma	13.3	CDKN2A, MDM2, SMARCB1
49	atypical polypoid adenomyoma	13.3	MME, MLH1
50	intravenous leiomyomatosis	13.3	ESR1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to uterine sarcoma:

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MGI Mouse Phenotypes related to uterine sarcoma:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	CSF1R, WT1
2	respiratory system phenotype	MP:0005388	10.0	MB
3	liver/biliary system phenotype	MP:0005370	9.8	SMARCB1, CYP19A1, ABCB1, ABL1, KIT
4	craniofacial phenotype	MP:0005382	9.7	CSF1, KIT, PDGFRA, PDGFRB, TWIST1
5	hematopoietic system phenotype	MP:0005397	9.2	MDM2, MB, SMARCB1, PDGFRA, ABL1, CSF1R
6	no phenotypic analysis	MP:0003012	9.1	ESR1, SLC2A1, MYC
7	other phenotype	MP:0005395	8.8	CSF1, KDR, CDKN2A, MME, PDGFRA, ABCB1
8	limbs/digits/tail phenotype	MP:0005371	8.8	MDM2, CSF1R, KIT, CSF1, TWIST1, PDGFRA
9	pigmentation phenotype	MP:0001186	8.4	KIT, MYC, CDKN2A, PDGFRA, PTEN, CYP19A1
10	embryogenesis phenotype	MP:0005380	8.1	KIT, ABL1, SMARCB1, ERBB2, MB, MDM2
11	reproductive system phenotype	MP:0005389	8.0	FLT1, MLH1, SMARCB1, ERBB2, PDGFRA, WT1
12	behavior/neurological phenotype	MP:0005386	7.8	FLT1, MDM2, PDGFRA, KIT, PTEN, CYP19A1
13	vision/eye phenotype	MP:0005391	7.5	CDKN2A, KDR, CSF1, ABL1, PDGFRB, SMARCB1
14	mortality/aging	MP:0010768	7.5	SLC2A1, MB, PTEN, SMARCB1, PDGFRA, PDGFRB
15	normal phenotype	MP:0002873	7.4	ABL1, WT1, PDGFRA, CYP19A1, KDR, MYC
16	immune system phenotype	MP:0005387	7.3	ABL1, TYMP, DCK, TERT, CSF1R, WT1
17	integument phenotype	MP:0010771	7.2	CSF1R, KIT, MLH1, CDK2, MME, MDM2
18	nervous system phenotype	MP:0003631	6.7	FLT1, KIT, TERT, PTEN, MYC, CYP19A1
19	tumorigenesis	MP:0002006	6.5	ERBB2, ESR1, MDM2, TERT, PTEN, PDGFRA
20	skeleton phenotype	MP:0005390	6.3	TYMP, ABL1, MYC, CYP19A1, ERBB2, ESR1
21	digestive/alimentary phenotype	MP:0005381	6.2	ERBB2, PDGFRA, ABL1, TWIST1, TERT, PDGFRB
22	muscle phenotype	MP:0005369	5.4	KIT, CYP19A1, PTEN, ERBB2, ESR1, MB
23	cardiovascular system phenotype	MP:0005385	5.4	MDM2, FLT1, CDK2, KDR, MYC, MB
24	growth/size phenotype	MP:0005378	4.4	ERBB2, MYC, KDR, CDK2, PDGFRB, CDKN2A
25	homeostasis/metabolism phenotype	MP:0005376	3.5	TYMP, CYP19A1, SMARCB1, PDGFRA, PDGFRB, WT1
26	cellular phenotype	MP:0005384	3.3	MLH1, SLC2A1, KIT, MYC, TERT, ERBB2

Articles related to uterine sarcoma:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	Wilms tumor gene 1 (WT1) is a prognostic marker in hi gh-grade uterine sarcoma. (21734473)	Coosemans A.... Amant F.	2011	WT1
2	Low frequency of somatic mutations in uterine sarcoma s: a molecular analysis and review of the literature. (20122944)	Murray S.... Papadimitriou C.A.	2010	KIT
3	Use of 18F-fluorodeoxyglucose positron emission tomog raphy for diagnosis of uterine sarcomas. (20204293)	Nagamatsu A.... Tanaka T.	2010	SLC2A1
4	Hormone receptor expression in uterine sarcomas: prog nostic and therapeutic roles. (19767065)	Ioffe Y.J.... Cass I.	2009	ESR1, CYP19A1
5	Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization cla ssification system. (19540555)	D'Angelo E.... Prat J.	2009	CDKN2A, MKI67, TWIST1
6	Effects of photoactivated 5-aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells. (18625294)	Chu E.S.... Ho R.J.	2008	ABCB1
7	KIT protein expression in uterine sarcomas: an immunohistochemical study and review of the literature. (18592792)	Zafrakas M.... Bontis J.	2008	KIT
8	Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis. (17291261)	Lee S.J.... Lee J.H.	2007	CAPN6
9	The effects of the CDK inhibitor seliciclib alone or in combination with cisplatin in human uterine sarcoma cell lines. (17300833)	Coley H.M.... Thomas H.	2007	CDK2
10	PDGFR-alpha as a potential therapeutic target in uterine sarcomas. (17049587)	Adams S.F.... Yamada S.D.	2007	PDGFRA, PDGFRB, KIT
11	Upregulation of Wilms' tumour gene 1 (WT1) in uterine sarcomas. (17531467)	Coosemans A.... Amant F.	2007	WT1
12	Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5. (17692467)	Greer D.A.... Ivey S.	2007	ABCB1
13	Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)	Kim S.H.... Ryu H.S.	2006	MDM2
14	Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. (16463058)	Jordheim L.P.... Dumontet C.	2006	DCK
15	Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)	Caudell J.J.... Ramondetta L.M.	2005	PDGFRB, KIT, ABL1
16	Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. (15921732)	Hua J.... Herzog T.J.	2005	ABCB1
17	Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. (15823121)	Arita S.... Nomura S.	2005	FLT1, KDR
18	ERBB-2 gene overexpression and amplification in uterine sarcomas. (15581967)	Amant F.... Vergote I.	2004	ERBB2
19	Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters. (15084350)	Kitaoka Y.... Honjo H.	2004	ESR1, CYP19A1, MKI67
20	Uterine sarcomas express KIT protein but lack mutation(s) in exon 11 or 17 of c-KIT. (14529657)	Rushing R.S.... Lele S.M.	2003	KIT
21	Telomerase activity in needle biopsied uterine myoma-like tumors: differential diagnosis between uterine sarcomas and leiomyomas. (11788902)	Tsujimura A.... Ogita S.	2002	TERT
22	PTEN mutations in uterine sarcomas. (11925138)	Amant F.... van Rensburg E.J.	2002	PTEN
23	Mutational analysis of the PTEN gene in human uterine sarcomas. (11349153)	Lancaster J.M.... Berchuck A.	2001	PTEN
24	Aggressive uterine sarcoma with rhabdoid features: diagnosis by peritoneal fluid cytology and absence of INI1 gene mutation. (11521235)	Knapik J.... Wilkinson E.J.	2001	SMARCB1
25	Lysosomal accumulation of drugs in drug-sensitive MES-SA but not multidrug-resistant MES-SA/Dx5 uterine sarcoma cells. (10867652)	Wang E.... Dunn K.W.	2000	ABCB1
26	Colony-stimulating factor-1 and its receptor do not have a role in the pathogenesis of uterine sarcomas. (10419732)	Anderson P.S.... Pollard J.W.	1999	CSF1R, CSF1
27	Expression of thymidine phosphorylase in uterine sarcoma and uterine leiomyoma: association with microvessel density and Doppler blood flow analysis. (9263424)	Hata K.... Miyazaki K.	1997	TYMP
28	Amplification of the mdm-2 gene and p53 abnormalities in uterine sarcomas. (9334806)	Seki A.... Kudo T.	1997	MDM2
29	Overexpression of the c-myc proto-oncogene occurs frequently in uterine sarcomas. (8539225)	Jeffers M.D.... Macaulay E.M.	1995	MYC
30	Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. (7585651)	Risinger J.I.... Barrett J.C.	1995	MLH1

Genes related to uterine sarcoma according to GeneCards:

(show all 32)

id	Symbol	Description	Score	GeneCards Section Context
1	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
2	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
3	DES	desmin	11.0
4	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
5	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
6	MME	membrane metallo-endopeptidase	11.0
7	MB	myoglobin	11.0
8	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
9	ESR1	estrogen receptor 1	11.0	Publications
10	LMTK3	lemur tyrosine kinase 3	11.0	Publications
11	CAPN6	calpain 6	11.0	Publications
12	DCK	deoxycytidine kinase	11.0	Publications
13	TWIST1	twist homolog 1 (Drosophila)	11.0	Publications
14	TYMP	thymidine phosphorylase	11.0	Publications
15	WT1	Wilms tumor 1	11.0	Publications
16	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
17	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
18	PTEN	phosphatase and tensin homolog	11.0	Publications
19	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
20	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
21	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
22	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
23	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
24	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11.0	Publications
25	CDK2	cyclin-dependent kinase 2	11.0	Publications
26	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
27	TERT	telomerase reverse transcriptase	11.0	Publications
28	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
29	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
30	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
31	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
32	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications

Pathways related to uterine sarcoma according to GeneDecks:

(show top 50)    (show all 79)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.2	LMTK3, ERBB2
2	Transcription P53 signaling pathway10	10.0	CDKN2A, CDK2
3	Akt Signaling36	9.8	LMTK3, KIT, CSF1, PDGFRB, PDGFRA, MDM2
4	Glioblastoma Multiforme36	9.8	PDGFRB, PDGFRA, PTEN, MDM2, CDK2
5	Glioma20	9.5	PDGFRB, PDGFRA, PTEN, MDM2, CDKN2A
6	Pathway_PA16595942534	9.5	KDR, KIT, PDGFRB, FLT1
7	Melanoma20	9.5	PTEN, MDM2, PDGFRA, PDGFRB, CDKN2A
8	Sorafenib Pharmacodynamics34	9.4	KDR, FLT1, PDGFRB
9	Prostate cancer20	9.2	PDGFRB, CDK2, PTEN, PDGFRA, ERBB2, MDM2
10	Angiogenesis3	9.1	KDR, FLT1, PDGFRA, PDGFRB, TYMP
11	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.1	CDKN2A, MDM2, MYC, ABL1
12	14-3-3 Induced Intracellular Signaling36	9.0	FLT1, CSF1R, PDGFRB, PDGFRA, ERBB2, LMTK3
13	ILK Signaling36	9.0	KIT, PDGFRA, LMTK3, KDR, ERBB2, PDGFRB
14	p53 Mediated Apoptosis36	9.0	PTEN, PDGFRA, PDGFRB, FLT1, MDM2, KDR
15	Transcription_P53 signaling pathway41	8.9	CDKN2A, KDR, FLT1, MDM2, CDK2
16	JNK Pathway36	8.9	PDGFRB, CSF1R, PDGFRA, KIT, FLT1, KDR
17	Ras Pathway36	8.8	KIT, LMTK3, FLT1, CSF1R, ERBB2, KDR
18	Mitochondrial Apoptosis36	8.8	MDM2, KIT, CDKN2A, KDR, PDGFRA, PDGFRB
19	Bladder cancer20	8.8	MYC, CDKN2A, MDM2, ERBB2, TYMP
20	Cellular Apoptosis Pathway36	8.8	KIT, KDR, CDKN2A, PDGFRB, PDGFRA, MDM2
21	Pathway_PA16598005034	8.7	PDGFRB, MYC, PDGFRA, FLT1, KDR
22	Cytokine-cytokine receptor interaction20	8.6	KIT, PDGFRA, FLT1, KDR, CSF1R, PDGFRB
23	PTEN Pathway36	8.5	KDR, KIT, FLT1, MDM2, PTEN, PDGFRA
24	Actin Nucleation and Branching36	8.5	CSF1R, PDGFRB, PDGFRA, ERBB2, FLT1, KDR
25	Actin Nucleation by ARP-WASP Complex36	8.5	KIT, KDR, FLT1, CSF1R, PDGFRB, PDGFRA
26	CDC42 Pathway36	8.5	PDGFRB, ERBB2, FLT1, KDR, LMTK3, KIT
27	Nanog in Mammalian ESC Pluripotency36	8.5	KIT, PDGFRA, PDGFRB, CSF1R, FLT1, KDR
28	Paxillin Interactions36	8.5	ERBB2, PDGFRB, FLT1, KDR, LMTK3, KIT
29	NFAT in Immune Response36	8.4	CSF1R, PDGFRB, PDGFRA, ERBB2, FLT1, KDR
30	GPCR Pathway36	8.4	KIT, CSF1R, PDGFRB, ERBB2, FLT1, KDR
31	GSK3 Signaling36	8.4	KIT, FLT1, CSF1R, PDGFRB, PDGFRA, LMTK3
32	Tyrosine Kinases / Adaptors3	8.4	FLT1, ERBB2, KDR, ABL1, KIT, PDGFRA
33	Focal adhesion20	8.4	PTEN, PDGFRB, PDGFRA, ERBB2, FLT1, KDR
34	eNOS Signaling36	8.3	PDGFRB, ESR1, FLT1, KDR, LMTK3, ERBB2
35	Estrogen Pathway36	8.3	KIT, KDR, FLT1, ESR1, ERBB2, PDGFRA
36	Activation of PKA through GPCR36	8.3	PDGFRA, CSF1R, PDGFRB, ERBB2, FLT1, KIT
37	Intracellular Calcium Signaling36	8.3	PDGFRA, KIT, LMTK3, KDR, ERBB2, PDGFRB
38	Antioxidant Action of Vitamin-C36	8.3	PDGFRA, PDGFRB, FLT1, KDR, KIT, CSF1
39	p38 Signaling36	8.2	FLT1, ERBB2, PDGFRA, PDGFRB, CSF1, CSF1R
40	Rho Family GTPases36	8.1	PDGFRA, CSF1R, ERBB2, FLT1, KDR, PDGFRB
41	Activation of cAMP-Dependent PKA36	7.9	ERBB2, FLT1, LMTK3, PDGFRA, KDR, PDGFRB
42	Telomerase Components in Cell Signaling36	7.9	PDGFRA, KIT, MYC, ABL1, TERT, FLT1
43	Pathways in cancer20	7.8	PTEN, MYC, CDK2, ERBB2, PDGFRA, ABL1
44	P2Y Receptor Signaling36	7.7	PDGFRB, KIT, LMTK3, MYC, KDR, FLT1
45	Pancreatic Adenocarcinoma36	7.7	MDM2, CSF1R, PDGFRB, KIT, LMTK3, KDR
46	JAK-STAT Pathway36	7.6	PDGFRA, FLT1, KDR, PDGFRB, CSF1R, MYC
47	Molecular Mechanisms of Cancer36	7.6	ABL1, PDGFRA, PTEN, MDM2, CDKN2A, CDK2
48	MAPK Signaling36	7.6	KIT, MYC, KDR, FLT1, ERBB2, PDGFRA
49	Endothelin-1 Signaling Pathway36	7.4	CSF1, PDGFRB, ERBB2, PDGFRA, KDR, LMTK3
50	ERK Signaling36	7.1	PDGFRA, ERBB2, ESR1, CSF1R, CSF1, PDGFRB

Compounds related to uterine sarcoma according to GeneDecks:

(show top 50)    (show all 226)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	DCK
2	vincristine32 34 9 9	13.5	KIT, DCK
3	threonine32	10.3	WT1, CSF1R
4	h2o232	9.8	CSF1, DES, PDGFRB, CDKN3, MME, MB
5	ly29400232	9.5	CDKN3, ERBB2, CSF1, SLC2A1
6	capecitabine32 34 9 9	12.3	TYMP, KIT, PDGFRB, CYP19A1, ERBB2, ABCB1
7	vinorelbine32 9 9	11.0	DCK, ABCB1, CYP19A1, ERBB2, MKI67, TYMP
8	taxane32	8.8	PTEN, ERBB2, CYP19A1, ESR1, KDR, ABCB1
9	erlotinib32 34 9 9	11.6	KIT, KDR, PDGFRB, CDKN3, ERBB2, PTEN
10	agar32	8.5	CDKN2A, ERBB2, PDGFRB, ABL1, CSF1, CSF1R
11	sunitinib32 9 9	10.5	KIT, KDR, FLT1, ERBB2, PDGFRA, PDGFRB
12	cysteine32	8.4	MDM2, PTEN, PDGFRB, TYMP, SLC2A1, KDR
13	trastuzumab32 34 9 9	11.4	CYP19A1, PTEN, KDR, CDK2, KIT, CDKN3
14	methotrexate32 34 42 9 9	12.4	KIT, DCK, ABCB1, TYMP, CYP19A1, ERBB2
15	gefitinib32 34 9 9	11.2	ABCB1, KIT, KDR, CDK2, CDKN3, MDM2
16	rapamycin32 42	9.2	KIT, KDR, CDK2, FLT1, MDM2, TERT
17	irinotecan32 34 9 9	11.2	KIT, CDKN2A, MLH1, TYMP, MDM2, MKI67
18	hydroxyurea32 9 9	10.0	MB, DCK, CSF1, CDK2, CDKN2A, KIT
19	cytarabine32 34 9 9	10.9	KIT, MYC, CDKN2A, MME, ABCB1, ABL1
20	adriamycin32	7.8	MYC, CDKN2A, DES, MME, ABCB1, MDM2
21	docetaxel32 34 9 9	10.7	PDGFRB, ABCB1, TYMP, CYP19A1, ERBB2, KIT
22	arginine32	7.7	ERBB2, CSF1, CDK2, MME, TERT, CYP19A1
23	estrogen32	7.6	KDR, MLH1, MKI67, ESR1, ERBB2, CYP19A1
24	thymidylate32	7.6	CDKN2A, CDK2, TERT, ERBB2, MDM2, ABCB1
25	wortmannin32 42	8.4	CSF1, KDR, CDKN3, MDM2, TERT, PTEN
26	gemcitabine32 34 9 9	10.4	MYC, KDR, MLH1, ERBB2, PTEN, CYP19A1
27	actinomycin d32	7.4	CSF1, DES, TYMP, ESR1, MDM2, MME
28	arsenite32 18	8.4	CDKN2A, CDK2, MYC, ABCB1, CSF1, SLC2A1
29	oxygen32 18	8.2	PDGFRB, FLT1, MLH1, CDKN2A, CDK2, MB
30	phosphotyrosine32	7.1	CSF1, ABL1, PDGFRB, PDGFRA, PTEN, ERBB2
31	steroid32	7.1	CYP19A1, MLH1, PTEN, ERBB2, MDM2, KIT
32	etoposide32 42 9 9	9.9	CDK2, CDKN3, MLH1, MDM2, ERBB2, TERT
33	tamoxifen32 34 9 9	9.9	MKI67, ESR1, ERBB2, MYC, KDR, CYP19A1
34	camptothecin32 42 9 9	9.8	MYC, KDR, CDK2, CDKN2A, CDKN3, MLH1
35	testosterone32 9 18 9	9.7	CDKN3, MME, MKI67, MDM2, MB, ESR1
36	cycloheximide32	6.2	KIT, SLC2A1, CSF1R, MYC, CDK2, CDKN2A
37	5fluorouracil32	6.0	KIT, KDR, CDK2, CDKN2A, MLH1, PDGFRB
38	imatinib32 34 9 9	8.9	ABL1, DES, CSF1, CSF1R, ABCB1, WT1
39	thymidine32 18	6.8	KIT, MYC, KDR, CDK2, MME, MLH1
40	progesterone32 42 9 18 9	9.7	KIT, CDK2, CDKN2A, MME, MLH1, MKI67
41	genistein32 9 18 9	8.6	CDKN3, TERT, PTEN, CYP19A1, PDGFRB, ABCB1
42	retinoic acid32 42 18	7.6	KIT, MYC, KDR, CDK2, CDKN2A, CDKN3
43	phosphatidylinositol32	5.4	KIT, SLC2A1, CSF1R, MYC, KDR, CDK2
44	paclitaxel32 34 9 9	7.7	CDK2, DCK, CSF1, TWIST1, TYMP, CDKN2A
45	doxorubicin32 34 9 9	7.5	MME, MLH1, MKI67, FLT1, MDM2, MB
46	cisplatin32 34 9 9	7.4	MB, ERBB2, TERT, PTEN, PDGFRB, ABCB1
47	serine32	4.4	MKI67, FLT1, MDM2, MB, ERBB2, TERT
48	paraffin32	4.3	CSF1R, SLC2A1, FLT1, MDM2, MB, ESR1
49	tyrosine32	3.5	KIT, LMTK3, MYC, KDR, CDK2, CDKN3
50	vegf32	3.3	WT1, ABL1, SLC2A1, CSF1R, CSF1, DES

Cellular components related to uterine sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic to plasma membrane	GO:031226	10.0	PDGFRB, PDGFRA
2	receptor complex	GO:043235	9.6	CSF1, ERBB2, CSF1R
3	nuclear body	GO:016604	9.1	MDM2, MYC, CDKN2A
4	nucleoplasm	GO:005654	7.5	SMARCB1, ESR1, MDM2, TERT, CDKN2A, CDK2
5	plasma membrane	GO:005886	6.9	SLC2A1, CSF1R, CSF1, ABCB1, KIT, KDR
6	nucleus	GO:005634	4.5	KIT, PTEN, SMARCB1, PDGFRA, PDGFRB, WT1

Biological processes related to uterine sarcoma according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	metanephric glomerular capillary formation	GO:072277	10.2	PDGFRB, PDGFRA
2	adrenal gland development	GO:030325	10.2	CYP19A1, PDGFRB, WT1
3	cell chemotaxis	GO:060326	10.2	PDGFRA, PDGFRB, KIT
4	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.1	PDGFRA, PDGFRB
5	pyrimidine nucleotide metabolic process	GO:006220	10.1	TYMP, DCK
6	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.0	PTEN, ESR1, KIT, SMARCB1
7	regulation of actin cytoskeleton reorganization	GO:2000249	9.9	CSF1R, ABL1, PDGFRA
8	replicative senescence	GO:090399	9.8	TERT, MME, CDKN2A
9	positive regulation of phospholipase C activity	GO:010863	9.8	FLT1, KIT, PDGFRA, PDGFRB
10	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.7	FLT1, PDGFRB, KIT, PDGFRA
11	signal transduction by phosphorylation	GO:023014	9.6	KIT, KDR, ERBB2
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.6	PDGFRA, KDR, CSF1R, PDGFRB
13	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.4	KDR, FLT1, PDGFRA, PDGFRB
14	phosphatidylinositol-mediated signaling	GO:048015	9.3	PTEN, PDGFRB, PDGFRA, ERBB2, CSF1R, MDM2
15	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.3	PDGFRB, PDGFRA, FLT1, KDR, KIT
16	positive regulation of MAP kinase activity	GO:043406	9.2	ERBB2, FLT1, PDGFRB
17	heart development	GO:007507	9.1	WT1, MB, ERBB2, PTEN
18	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	9.0	ERBB2, CSF1R, FLT1, KDR
19	positive regulation of cell migration	GO:030335	9.0	FLT1, KDR, PDGFRB, CSF1, CSF1R, PDGFRA
20	peptidyl-tyrosine phosphorylation	GO:018108	8.8	CSF1R, PDGFRB, PDGFRA, FLT1, KDR, ABL1
21	negative regulation of apoptotic process	GO:043066	8.6	KDR, MYC, PTEN, WT1, MDM2
22	protein autophosphorylation	GO:046777	8.6	PDGFRA, CSF1R, FLT1, PDGFRB, ERBB2, KDR
23	positive regulation of cell proliferation	GO:008284	7.3	KDR, CSF1, PDGFRB, PDGFRA, PTEN, MDM2

Molecular functions related to uterine sarcoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor receptor binding	GO:005161	9.8	PDGFRB, PDGFRA, TYMP
2	vascular endothelial growth factor binding	GO:038085	9.7	KDR, PDGFRA, PDGFRB
3	receptor signaling protein tyrosine kinase activity	GO:004716	9.4	KDR, KIT, ERBB2
4	vascular endothelial growth factor-activated receptor activity	GO:005021	9.3	PDGFRB, FLT1, KDR, PDGFRA
5	growth factor binding	GO:019838	9.0	KDR, FLT1, ERBB2
6	protein tyrosine kinase activity	GO:004713	8.9	KIT, KDR, ABL1, PDGFRB, LMTK3, ERBB2
7	transmembrane receptor protein tyrosine kinase activity	GO:004714	8.8	FLT1, KIT, KDR, ERBB2, PDGFRA
8	protein homodimerization activity	GO:042803	8.5	CSF1R, CSF1, DCK, TWIST1, PDGFRA, TERT
9	ATP binding	GO:005524	6.3	FLT1, LMTK3, KDR, CDK2, PDGFRB, PDGFRA
10	protein binding	GO:005515	3.6	MME, ESR1, CDKN2A, CDK2, MDM2, KDR