MCID: UTR043
MIFTS: 45

Uterine Sarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Uterine Sarcoma

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Wikipedia:65 The uterine sarcomas form a group of malignant tumors that arises from the smooth muscle or connective... more...

MalaCards based summary: Uterine Sarcoma, also known as sarcoma of the uterus, is related to alveolar soft part sarcoma and sarcoma. An important gene associated with Uterine Sarcoma is DES (desmin), and among its related pathways are Hematopoietic cell lineage and Sorafenib Pharmacodynamics. The compounds toluidine and su6668 have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Uterine Sarcoma

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Uterine Sarcoma, Aliases & Descriptions:

Name: Uterine Sarcoma 42 44
Sarcoma of the Uterus 42 62
 
Uterine Corpus Sarcoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Uterine Sarcoma

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Diseases related to Uterine Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1alveolar soft part sarcoma31.3MB
2sarcoma31.0MB, KIT, PDGFRB, DES, ABCB1
3leiomyoma30.8DES, MME, KIT
4synovial sarcoma30.5KIT, DES
5adenosarcoma30.2MB, MME, DES
6endometrial stromal sarcoma29.9DES, MME, PDGFRB, KIT
7wilms tumor29.9ABCB1, DES, MME
8leiomyosarcoma29.4DES, MME, PDGFRB, KIT, MB
9uterine inversion10.6
10infantile myofibromatosis10.5DES
11carney triad10.4KIT
12myositis10.4MB
13myelofibrosis10.3PDGFRB
14myeloid sarcoma10.3
15liposarcoma10.3DES, MB
16granular cell tumor10.3MB, DES
17alveolar rhabdomyosarcoma10.3DES, MB
18embryonal rhabdomyosarcoma10.3DES, MB
19dedifferentiated liposarcoma10.3DES, KIT
20angiomyolipoma10.2KIT, DES
21neuromuscular disease10.2MB, DES
22phyllode tumor10.2KIT, MME
23duchenne muscular dystrophy10.2MB, DES
24breast cancer10.2
25peritonitis10.2
26mast-cell sarcoma10.2
27cellular leiomyoma10.2
28vaginitis10.2
29splenomegaly10.2
30chordoma10.2DES, PDGFRB
31factor vii deficiency10.2MB, KIT
32malignant fibroxanthoma10.2PDGFRB, DES
33systemic mastocytosis10.1PDGFRB, KIT
34leukemia, acute lymphoblastic 310.1KIT, MME
35hypereosinophilic syndrome10.1PDGFRB, KIT
36oxyphilic adenoma10.1MME, KIT
37pdgfrb-associated chronic eosinophilic leukemia10.1KIT, PDGFRB
38mastocytosis10.1PDGFRB, KIT
39neurofibroma10.1KIT, PDGFRB
40salivary gland adenoid cystic carcinoma10.1PDGFRB, KIT
41polycythemia vera10.1PDGFRB, KIT
42malignant mesothelioma10.1PDGFRB, DES
43malignant mixed mullerian tumor10.1MB, KIT, DES
44acute myeloid leukemia, adult10.0KIT, ABCB1
45smooth muscle tumor10.0KIT, MME, DES
46cervical cancer10.0
47myoma10.0
48uterine carcinosarcoma10.0
49adenocarcinoma10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Uterine Sarcoma:



Diseases related to uterine sarcoma

Symptoms for Uterine Sarcoma

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Drugs & Therapeutics for Uterine Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Uterine Sarcoma

Search NIH Clinical Center for Uterine Sarcoma

Genetic Tests for Uterine Sarcoma

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Anatomical Context for Uterine Sarcoma

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MalaCards organs/tissues related to Uterine Sarcoma:

32
Uterus, Smooth muscle, Breast, Bone marrow, Bone, Brain, Colon, Placenta, Endothelial

Animal Models for Uterine Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Uterine Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PDGFRB, KIT, MB
2MP:00107687.6MB, KIT, PDGFRB, DES, ABCB1
3MP:00053857.5ABCB1, DES, PDGFRB, KIT, MB
4MP:00053767.1MB, KIT, PDGFRB, MME, DES, ABCB1

Publications for Uterine Sarcoma

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Articles related to Uterine Sarcoma:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells. (24618889)
2014
2
Undifferentiated uterine sarcoma: a rare, not well known and aggressive disease: report of 13 cases. (24958349)
2014
3
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
4
Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. (22911740)
2012
5
Role of FDG PET-CT in detecting recurrence in patients with uterine sarcoma: comparison with conventional imaging. (22107993)
2012
6
Preface. Uterine sarcoma. (21764644)
2011
7
Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. (21734473)
2011
8
Uterine sarcoma: a rare cause of uterine inversion. (21982891)
2011
9
Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature. (20122944)
2010
10
Undifferentiated uterine sarcoma presenting as a pathologic humerus fracture. (20882934)
2010
11
Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. (20151639)
2010
12
Prognostic impact of parity in 493 uterine sarcoma patients. (19820369)
2009
13
Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma. (18308380)
2008
14
Uterine sarcoma: clinicopathological characteristics, treatment and outcome in Iran. (18990014)
2008
15
The management of patients with uterine sarcoma: a debated clinical challenge. (17706430)
2008
16
Huge uterine leiomyoma with adenomyotic cysts mimicking uterine sarcoma on MR imaging. (17450337)
2007
17
Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)
2006
18
Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)
2005
19
Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. (15921732)
2005
20
Characteristics and management of uterine sarcoma patients treated at the Tom Baker Cancer Centre. (15670308)
2005
21
Treatment of uterine sarcoma at the University of Florence from 1980-2001. (15948541)
2005
22
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study. (15675470)
2004
23
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
24
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. (12801270)
2003
25
Prognostic value of initial surgical procedure for patients with uterine sarcoma: analysis of 123 patients. (12807231)
2003
26
A spontaneous uterine sarcoma in a rhesus monkey (Macaca mulatta). (12450192)
2002
27
Prognostic factors and treatment modalities in uterine sarcoma. (12040283)
2002
28
Two patients with sarcoma. Case 2. Uterine sarcoma. (10829056)
2000
29
Cold agglutinin disease in a patient with uterine sarcoma. (11093691)
2000
30
Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcoma. (10926807)
2000
31
Uterine sarcoma: the Hacettepe hospital experience of 88 consecutive patients. (9105869)
1997
32
Uterine sarcoma: a clinicopathological study of 93 cases. (9174834)
1997
33
Uterine sarcoma. (8784887)
1996
34
Paraneoplastic retinopathy associated with uterine sarcoma. (7789878)
1995
35
Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. (8381710)
1993
36
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
37
Establishment of human uterine sarcoma in nude mice. (2584825)
1989
38
Advanced uterine sarcoma; response to chemotherapy. (3383890)
1988
39
Adjuvant therapy for stage I uterine sarcoma. (3826216)
1987
40
Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. (3793549)
1986
41
Uterine sarcoma in Israel: a study of 104 cases. (4065710)
1985
42
Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). (3884128)
1985
43
Treatment of advanced uterine sarcoma with adriamycin. (6884822)
1983
44
Treatment of advanced uterine sarcoma with vincristine, actinomycin D, and cyclophosphamide. (6687580)
1983
45
Diagnostic problems in differentiation of uterine sarcoma. (7443578)
1980
46
Uterine sarcoma and policy of management. (7228094)
1980
47
Prophylactic chemotherapy in stages I and II uterine sarcoma. (511000)
1979
48
Stage III uterine sarcoma: case report and literature review. (378775)
1979
49
Clinical aspects and pathology of uterine sarcoma. (13779542)
1961
50
Uterine sarcoma simulating placenta praevia. (13385739)
1956

Variations for Uterine Sarcoma

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Expression for genes affiliated with Uterine Sarcoma

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Expression patterns in normal tissues for genes affiliated with Uterine Sarcoma

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Pathways for genes affiliated with Uterine Sarcoma

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Compounds for genes affiliated with Uterine Sarcoma

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Compounds related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1toluidine449.9DES, KIT
2su6668449.7PDGFRB, KIT
3zd6474449.7KIT, PDGFRB
4pkc 412449.7PDGFRB, KIT
5ag-1296449.7KIT, PDGFRB
6su5416449.7PDGFRB, KIT
7cilazapril44 1110.5MME, ABCB1
8nilotinib50 1110.5KIT, ABCB1
9lisinopril44 50 24 1112.4MME, ABCB1
10loperamide44 24 1111.4MME, ABCB1
11rhodamine 12344 5010.3KIT, ABCB1
12bromodeoxyuridine449.3DES, MME, PDGFRB
13ponatinib50 1110.3KIT, ABCB1
144-hydroxynonenal44 2410.3MB, PDGFRB, MME
15naltrexone44 28 50 1112.2ABCB1, MME
16trifluoperazine44 28 50 1112.2MB, ABCB1
17phenylalanine449.1MME, PDGFRB, KIT
18acetylcholine44 50 28 24 1113.1DES, MME, MB
19enalapril44 50 1111.0MME, ABCB1
20ribonucleic acid449.0KIT, PDGFRB, MME
21cytarabine44 50 1111.0KIT, MME, ABCB1
22lactate449.0DES, MME, KIT, MB
23capecitabine44 50 1111.0KIT, PDGFRB, ABCB1
24pazopanib50 119.9ABCB1, PDGFRB, KIT
25sunitinib44 50 1110.9KIT, PDGFRB, ABCB1
26regorafenib50 119.9ABCB1, PDGFRB, KIT
27dasatinib44 50 1110.9KIT, PDGFRB, ABCB1
28erlotinib44 50 1110.9KIT, PDGFRB, ABCB1
29sorafenib44 50 1110.9KIT, PDGFRB, ABCB1
30gefitinib44 50 1110.9KIT, PDGFRB, ABCB1
31ketamine44 28 1110.9MB, ABCB1
32docetaxel44 50 61 1111.9KIT, PDGFRB, ABCB1
33h2o2448.8DES, MME, PDGFRB, MB
34methionine448.8DES, MME, PDGFRB, KIT
355fluorouracil448.8KIT, PDGFRB, ABCB1
36oxygen44 249.7MB, PDGFRB, MME, DES
37adriamycin448.7ABCB1, DES, MME, MB
38estrogen448.7DES, MME, PDGFRB, KIT
39retinoic acid44 249.6DES, MME, PDGFRB, KIT
40actinomycin d448.6ABCB1, DES, MME, KIT
41glucose448.6DES, MME, PDGFRB, KIT
42paclitaxel44 50 1110.6KIT, PDGFRB, ABCB1
43imatinib44 50 1110.5ABCB1, DES, PDGFRB, KIT
44paraffin448.4MB, KIT, PDGFRB, MME, DES
45vegf448.4DES, MME, PDGFRB, KIT, MB
46cysteine448.4DES, MME, PDGFRB, KIT, MB
47serine448.3DES, MME, PDGFRB, KIT, MB
48doxorubicin44 50 1110.2ABCB1, DES, MME, KIT, MB
49progesterone44 28 61 24 1112.0ABCB1, DES, MME, PDGFRB, KIT
50testosterone44 61 24 1110.6MB, KIT, PDGFRB, MME, DES, ABCB1

GO Terms for genes affiliated with Uterine Sarcoma

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Biological processes related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.4KIT, PDGFRB
2response to hydrogen peroxideGO:0425429.4MB, PDGFRB
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4KIT, PDGFRB
4peptidyl-tyrosine phosphorylationGO:0181089.3KIT, PDGFRB
5cell chemotaxisGO:0603269.2PDGFRB, KIT
6positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.0KIT, PDGFRB

Molecular functions related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3KIT, PDGFRB

Products for genes affiliated with Uterine Sarcoma

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Sources for Uterine Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet