MCID: UTR043
MIFTS: 39

Uterine Sarcoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Uterine Sarcoma

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Sources:
60UMLS, 41NIH Rare Diseases, 43Novoseek
See all sources

Uterine Sarcoma, Aliases & Descriptions:

Name: Uterine Sarcoma 41 43
Uterine Corpus Sarcoma 60
 
Sarcoma of the Uterus 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Uterine Sarcoma

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Wikipedia:63 The uterine sarcomas form a group of malignant tumors that arises from the smooth muscle or connective... more...

MalaCards based summary: Uterine Sarcoma, also known as uterine corpus sarcoma, is related to alveolar soft-part sarcoma and sarcoma. An important gene associated with Uterine Sarcoma is DES (desmin), and among its related pathways are Hematopoietic cell lineage and Sorafenib Pharmacodynamics. The compounds toluidine and su6668 have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and mortality/aging.

Related Diseases for Uterine Sarcoma

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Diseases related to Uterine Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1alveolar soft-part sarcoma31.3MB
2sarcoma31.0MB, KIT, PDGFRB, DES, ABCB1
3leiomyoma30.8DES, MME, KIT
4adenosarcoma30.1MB, MME, DES
5endometrial stromal sarcoma29.9DES, MME, PDGFRB, KIT
6wilms tumor29.9ABCB1, DES, MME
7leiomyosarcoma29.4DES, MME, PDGFRB, KIT, MB
8uterine inversion10.6
9infantile myofibromatosis10.5DES
10carney triad10.4KIT
11myositis10.3MB
12myelofibrosis10.3PDGFRB
13myeloid sarcoma10.3
14liposarcoma10.3DES, MB
15granular cell tumor10.3MB, DES
16rhabdomyosarcoma 2, alveolar10.3DES, MB
17embryonal rhabdomyosarcoma10.2DES, MB
18dedifferentiated liposarcoma10.2DES, KIT
19angiomyolipoma10.2KIT, DES
20neuromuscular disease10.2MB, DES
21benign breast phyllodes tumor10.2KIT, MME
22breast cancer10.2
23peritonitis10.2
24duchenne muscular dystrophy10.2MB, DES
25mast-cell sarcoma10.2
26cellular leiomyoma10.2
27vaginitis10.2
28splenomegaly10.2
29sarcoma, synovial10.2KIT, DES
30chordoma10.2DES, PDGFRB
31factor vii deficiency10.2MB, KIT
32malignant fibroxanthoma10.2PDGFRB, DES
33hypereosinophilic syndrome, idiopathic, resistant to imatinib10.1KIT, PDGFRB
34systemic mastocytosis10.1PDGFRB, KIT
35precursor b-cell acute lymphoblastic leukemia10.1KIT, MME
36hypereosinophilic syndrome10.1PDGFRB, KIT
37oxyphilic adenoma10.1MME, KIT
38chronic myelomonocytic leukemia10.1KIT, PDGFRB
39mastocytosis10.1PDGFRB, KIT
40neurofibroma10.1KIT, PDGFRB
41salivary gland adenoid cystic carcinoma10.1PDGFRB, KIT
42polycythemia vera10.1PDGFRB, KIT
43mesothelioma, somatic10.1PDGFRB, DES
44mesothelioma10.1PDGFRB, DES
45malignant mixed mullerian tumor10.1MB, KIT, DES
46acute myeloid leukemia, adult10.0KIT, ABCB1
47myoma10.0
48uterine carcinosarcoma10.0
49adenocarcinoma10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Uterine Sarcoma:



Diseases related to uterine sarcoma

Symptoms for Uterine Sarcoma

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Drugs & Therapeutics for Uterine Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Uterine Sarcoma

Search NIH Clinical Center for Uterine Sarcoma

Genetic Tests for Uterine Sarcoma

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Anatomical Context for Uterine Sarcoma

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MalaCards organs/tissues related to Uterine Sarcoma:

31
Uterus, Smooth muscle, Breast, Bone marrow, Bone, Brain, Colon, Placenta, Endothelial

Animal Models for Uterine Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Uterine Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PDGFRB, KIT, MB
2MP:00107687.6MB, KIT, PDGFRB, DES, ABCB1
3MP:00053857.5ABCB1, DES, PDGFRB, KIT, MB
4MP:00053767.1MB, KIT, PDGFRB, MME, DES, ABCB1

Publications for Uterine Sarcoma

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Articles related to Uterine Sarcoma:

(show top 50)    (show all 231)
idTitleAuthorsYear
1
Surgical Methods for the Treatment of Uterine Fibroids - Risk of Uterine Sarcoma and Problems of Morcellation: Position Paper of the DGGG. (25797958)
2015
2
Population-based estimates of the prevalence of uterine sarcoma among patients with leiomyomata undergoing surgical treatment. (25650751)
2015
3
Outcome analysis in patients with uterine sarcoma. (25874175)
2015
4
Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells. (24618889)
2014
5
Undifferentiated uterine sarcoma: a rare, not well known and aggressive disease: report of 13 cases. (24958349)
2014
6
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
7
Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. (22911740)
2012
8
Preface. Uterine sarcoma. (21764644)
2011
9
Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. (21734473)
2011
10
Uterine sarcoma: a rare cause of uterine inversion. (21982891)
2011
11
Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature. (20122944)
2010
12
Undifferentiated uterine sarcoma presenting as a pathologic humerus fracture. (20882934)
2010
13
Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. (20151639)
2010
14
Prognostic impact of parity in 493 uterine sarcoma patients. (19820369)
2009
15
Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma. (18308380)
2008
16
Uterine sarcoma: clinicopathological characteristics, treatment and outcome in Iran. (18990014)
2008
17
The management of patients with uterine sarcoma: a debated clinical challenge. (17706430)
2008
18
Huge uterine leiomyoma with adenomyotic cysts mimicking uterine sarcoma on MR imaging. (17450337)
2007
19
Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)
2006
20
Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)
2005
21
Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. (15921732)
2005
22
Characteristics and management of uterine sarcoma patients treated at the Tom Baker Cancer Centre. (15670308)
2005
23
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study. (15675470)
2004
24
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
25
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. (12801270)
2003
26
Prognostic value of initial surgical procedure for patients with uterine sarcoma: analysis of 123 patients. (12807231)
2003
27
A spontaneous uterine sarcoma in a rhesus monkey (Macaca mulatta). (12450192)
2002
28
Prognostic factors and treatment modalities in uterine sarcoma. (12040283)
2002
29
Two patients with sarcoma. Case 2. Uterine sarcoma. (10829056)
2000
30
Cold agglutinin disease in a patient with uterine sarcoma. (11093691)
2000
31
Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcoma. (10926807)
2000
32
Uterine sarcoma: the Hacettepe hospital experience of 88 consecutive patients. (9105869)
1997
33
Uterine sarcoma: a clinicopathological study of 93 cases. (9174834)
1997
34
Uterine sarcoma. (8784887)
1996
35
Paraneoplastic retinopathy associated with uterine sarcoma. (7789878)
1995
36
Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. (8381710)
1993
37
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
38
Establishment of human uterine sarcoma in nude mice. (2584825)
1989
39
Advanced uterine sarcoma; response to chemotherapy. (3383890)
1988
40
Adjuvant therapy for stage I uterine sarcoma. (3826216)
1987
41
Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. (3793549)
1986
42
Uterine sarcoma in Israel: a study of 104 cases. (4065710)
1985
43
Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). (3884128)
1985
44
Treatment of advanced uterine sarcoma with adriamycin. (6884822)
1983
45
Treatment of advanced uterine sarcoma with vincristine, actinomycin D, and cyclophosphamide. (6687580)
1983
46
Uterine sarcoma and policy of management. (7228094)
1980
47
Prophylactic chemotherapy in stages I and II uterine sarcoma. (511000)
1979
48
Stage III uterine sarcoma: case report and literature review. (378775)
1979
49
Clinical aspects and pathology of uterine sarcoma. (13779542)
1961
50
Uterine sarcoma simulating placenta praevia. (13385739)
1956

Variations for Uterine Sarcoma

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Expression for genes affiliated with Uterine Sarcoma

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Search GEO for disease gene expression data for Uterine Sarcoma.

Pathways for genes affiliated with Uterine Sarcoma

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Compounds for genes affiliated with Uterine Sarcoma

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Compounds related to Uterine Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1toluidine439.9KIT, DES
2su6668439.7PDGFRB, KIT
3zd6474439.7KIT, PDGFRB
4pkc 412439.7PDGFRB, KIT
5ag-1296439.7KIT, PDGFRB
6su5416439.7KIT, PDGFRB
7cilazapril43 1210.5MME, ABCB1
8nilotinib49 1210.5ABCB1, KIT
9lisinopril43 49 24 1212.4ABCB1, MME
10loperamide43 24 1211.4MME, ABCB1
11rhodamine 12343 4910.3ABCB1, KIT
12bromodeoxyuridine439.3DES, MME, PDGFRB
13ponatinib49 1210.3ABCB1, KIT
144-hydroxynonenal43 2410.3PDGFRB, MB, MME
15naltrexone43 28 49 1212.2MME, ABCB1
16trifluoperazine43 28 49 1212.2ABCB1, MB
17phenylalanine439.1MME, PDGFRB, KIT
18acetylcholine43 49 28 24 1213.1DES, MME, MB
19enalapril43 49 1211.0ABCB1, MME
20ribonucleic acid439.0PDGFRB, MME, KIT
21cytarabine43 49 1211.0ABCB1, MME, KIT
22lactate439.0KIT, MME, MB, DES
23capecitabine43 49 1211.0PDGFRB, ABCB1, KIT
24pazopanib49 129.9KIT, PDGFRB, ABCB1
25sunitinib43 49 1210.9KIT, PDGFRB, ABCB1
26regorafenib49 129.9KIT, PDGFRB, ABCB1
27dasatinib43 49 1210.9ABCB1, KIT, PDGFRB
28erlotinib43 49 1210.9PDGFRB, ABCB1, KIT
29sorafenib43 49 1210.9KIT, ABCB1, PDGFRB
30gefitinib43 49 1210.9PDGFRB, ABCB1, KIT
31ketamine43 28 1210.9MB, ABCB1
32docetaxel43 49 59 1211.9ABCB1, PDGFRB, KIT
33h2o2438.8MME, MB, PDGFRB, DES
34methionine438.8DES, MME, PDGFRB, KIT
355fluorouracil438.8ABCB1, KIT, PDGFRB
36oxygen43 249.7MB, PDGFRB, DES, MME
37adriamycin438.7DES, ABCB1, MME, MB
38estrogen438.7KIT, MME, DES, PDGFRB
39retinoic acid43 249.6DES, MME, PDGFRB, KIT
40actinomycin d438.6KIT, DES, MME, ABCB1
41glucose438.6DES, PDGFRB, KIT, MME
42paclitaxel43 49 1210.6ABCB1, KIT, PDGFRB
43imatinib43 49 1210.5ABCB1, DES, PDGFRB, KIT
44paraffin438.4PDGFRB, DES, KIT, MB, MME
45vegf438.4MB, MME, KIT, PDGFRB, DES
46cysteine438.4MME, MB, DES, PDGFRB, KIT
47serine438.3MME, DES, MB, KIT, PDGFRB
48doxorubicin43 49 1210.2MB, DES, ABCB1, KIT, MME
49progesterone43 28 59 24 1212.0PDGFRB, MME, KIT, ABCB1, DES
50testosterone43 59 24 1210.6KIT, MB, PDGFRB, MME, DES, ABCB1

GO Terms for genes affiliated with Uterine Sarcoma

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Biological processes related to Uterine Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:00108639.4KIT, PDGFRB
2response to hydrogen peroxideGO:00425429.4MB, PDGFRB
3positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4KIT, PDGFRB
4peptidyl-tyrosine phosphorylationGO:00181089.3KIT, PDGFRB
5cell chemotaxisGO:00603269.2PDGFRB, KIT
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.0KIT, PDGFRB

Molecular functions related to Uterine Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.3KIT, PDGFRB

Products for genes affiliated with Uterine Sarcoma

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Sources for Uterine Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet