MCID: UTR043
MIFTS: 45

Uterine Sarcoma malady

Rare diseases, Cancer diseases categories

Summaries for Uterine Sarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 The uterine sarcomas form a group of malignant tumors that arises from the smooth muscle or connective... more...

MalaCards: Uterine Sarcoma, also known as uterine corpus sarcoma, is related to sarcoma and alveolar soft part sarcoma. An important gene associated with Uterine Sarcoma is DES (desmin), and among its related pathways are Hematopoietic cell lineage and Sorafenib Pharmacodynamics. The compounds toluidine and su6668 have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Uterine Sarcoma

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63UMLS, 44NIH Rare Diseases, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

uterine sarcoma 44 46
uterine corpus sarcoma 63
sarcoma of the uterus 44


Related Diseases for Uterine Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Uterine Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.6DES, KIT, MB, ABCB1, PDGFRB
2alveolar soft part sarcoma30.8MB
3leiomyoma30.7MME, KIT, DES
4synovial sarcoma30.3DES, KIT
5endometrial stromal sarcoma30.2PDGFRB, MME, DES, KIT
6adenosarcoma30.1MB, MME, DES
7wilms tumor30.0ABCB1, MME, DES
8leiomyosarcoma29.9MME, MB, KIT, PDGFRB, DES
9uterine inversion10.6
10myeloid sarcoma10.3
11breast cancer10.2
12peritonitis10.2
13mast-cell sarcoma10.2
14cellular leiomyoma10.2
15vaginitis10.2
16splenomegaly10.2
17infantile myofibromatosis10.1DES
18carney triad10.1KIT
19myositis10.1MB
20myelofibrosis10.1PDGFRB
21liposarcoma10.1DES, MB
22granular cell tumor10.1MB, DES
23alveolar rhabdomyosarcoma10.1DES, MB
24embryonal rhabdomyosarcoma10.1MB, DES
25dedifferentiated liposarcoma10.1KIT, DES
26angiomyolipoma10.1KIT, DES
27neuromuscular disease10.0DES, MB
28phyllode tumor10.0MME, KIT
29duchenne muscular dystrophy10.0MB, DES
30chordoma10.0DES, PDGFRB
31factor vii deficiency10.0MB, KIT
32malignant fibroxanthoma10.0DES, PDGFRB
33systemic mastocytosis10.0PDGFRB, KIT
34leukemia, acute lymphoblastic 310.0KIT, MME
35hypereosinophilic syndrome10.0PDGFRB, KIT
36oxyphilic adenoma10.0MME, KIT
37chronic myelomonocytic leukemia10.0PDGFRB, KIT
38mastocytosis10.0KIT, PDGFRB
39neurofibroma10.0PDGFRB, KIT
40adenoid cystic carcinoma10.0PDGFRB, KIT
41myoma10.0
42uterine carcinosarcoma10.0
43adenocarcinoma10.0
44cervical cancer10.0
45cervicitis10.0
46endometritis10.0
47meningioma10.0
48placenta praevia10.0
49clostridium perfringens infection10.0
50cold agglutinin disease10.0

Graphical network of the top 20 diseases related to Uterine Sarcoma:



Diseases related to uterine sarcoma

Symptoms for Uterine Sarcoma

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Drugs & Therapeutics for Uterine Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Uterine Sarcoma

Drug clinical trials:

Search ClinicalTrials for Uterine Sarcoma

Search NIH Clinical Center for Uterine Sarcoma

Search CenterWatch for Uterine Sarcoma

Genetic Tests for Uterine Sarcoma

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Anatomical Context for Uterine Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Uterine Sarcoma:

34
Uterus, Smooth muscle, Breast, Bone marrow, Bone, Brain, Colon, Placenta, Endothelial

Animal Models for Uterine Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Uterine Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PDGFRB, KIT, MB
2MP:00107687.6MB, KIT, PDGFRB, DES, ABCB1
3MP:00053857.5ABCB1, DES, PDGFRB, KIT, MB
4MP:00053767.1MB, KIT, PDGFRB, MME, DES, ABCB1

Publications for Uterine Sarcoma

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53PubMed
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Articles related to Uterine Sarcoma:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
2
Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. (22911740)
2012
3
Role of FDG PET-CT in detecting recurrence in patients with uterine sarcoma: comparison with conventional imaging. (22107993)
2012
4
Preface. Uterine sarcoma. (21764644)
2011
5
Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. (21734473)
2011
6
Uterine sarcoma: a rare cause of uterine inversion. (21982891)
2011
7
Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature. (20122944)
2010
8
Undifferentiated uterine sarcoma presenting as a pathologic humerus fracture. (20882934)
2010
9
Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. (20151639)
2010
10
Prognostic impact of parity in 493 uterine sarcoma patients. (19820369)
2009
11
Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma. (18308380)
2008
12
Uterine sarcoma: clinicopathological characteristics, treatment and outcome in Iran. (18990014)
2008
13
The management of patients with uterine sarcoma: a debated clinical challenge. (17706430)
2008
14
Huge uterine leiomyoma with adenomyotic cysts mimicking uterine sarcoma on MR imaging. (17450337)
2007
15
Uterine sarcoma occurring in a premenopausal patient after uterine artery embolization: a case report and review of the literature. (17083970)
2007
16
Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)
2006
17
Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)
2005
18
Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. (15921732)
2005
19
Characteristics and management of uterine sarcoma patients treated at the Tom Baker Cancer Centre. (15670308)
2005
20
Treatment of uterine sarcoma at the University of Florence from 1980-2001. (15948541)
2005
21
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study. (15675470)
2004
22
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
23
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. (12801270)
2003
24
Prognostic value of initial surgical procedure for patients with uterine sarcoma: analysis of 123 patients. (12807231)
2003
25
A spontaneous uterine sarcoma in a rhesus monkey (Macaca mulatta). (12450192)
2002
26
Prognostic factors and treatment modalities in uterine sarcoma. (12040283)
2002
27
Two patients with sarcoma. Case 2. Uterine sarcoma. (10829056)
2000
28
Cold agglutinin disease in a patient with uterine sarcoma. (11093691)
2000
29
Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcoma. (10926807)
2000
30
Uterine sarcoma: the Hacettepe hospital experience of 88 consecutive patients. (9105869)
1997
31
Uterine sarcoma: a clinicopathological study of 93 cases. (9174834)
1997
32
Uterine sarcoma: diagnosis with multiparameter sonographic analysis. (9339532)
1997
33
Uterine sarcoma. (8784887)
1996
34
Paraneoplastic retinopathy associated with uterine sarcoma. (7789878)
1995
35
Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. (8381710)
1993
36
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
37
Establishment of human uterine sarcoma in nude mice. (2584825)
1989
38
Advanced uterine sarcoma; response to chemotherapy. (3383890)
1988
39
Adjuvant therapy for stage I uterine sarcoma. (3826216)
1987
40
Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. (3793549)
1986
41
Uterine sarcoma in Israel: a study of 104 cases. (4065710)
1985
42
Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). (3884128)
1985
43
Treatment of advanced uterine sarcoma with adriamycin. (6884822)
1983
44
Treatment of advanced uterine sarcoma with vincristine, actinomycin D, and cyclophosphamide. (6687580)
1983
45
Diagnostic problems in differentiation of uterine sarcoma. (7443578)
1980
46
Uterine sarcoma and policy of management. (7228094)
1980
47
Prophylactic chemotherapy in stages I and II uterine sarcoma. (511000)
1979
48
Stage III uterine sarcoma: case report and literature review. (378775)
1979
49
Clinical aspects and pathology of uterine sarcoma. (13779542)
1961
50
Uterine sarcoma simulating placenta praevia. (13385739)
1956

Variations for Uterine Sarcoma

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Expression for genes affiliated with Uterine Sarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uterine Sarcoma

Search GEO for disease gene expression data for Uterine Sarcoma.

Pathways for genes affiliated with Uterine Sarcoma

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Sources:
51PathCards, 31KEGG, 52PharmGKB, 62Tocris Bioscience, 13EMD Millipore
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Compounds for genes affiliated with Uterine Sarcoma

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1toluidine469.9KIT, DES
2su6668469.7PDGFRB, KIT
3zd6474469.7KIT, PDGFRB
4pkc 412469.7PDGFRB, KIT
5ag-1296469.7KIT, PDGFRB
6su5416469.7KIT, PDGFRB
7cilazapril46 1210.5MME, ABCB1
8nilotinib52 1210.5ABCB1, KIT
9lisinopril46 52 25 1212.4ABCB1, MME
10loperamide46 25 1211.4MME, ABCB1
11rhodamine 12346 5210.3ABCB1, KIT
12bromodeoxyuridine469.3DES, MME, PDGFRB
13ponatinib52 1210.3ABCB1, KIT
144-hydroxynonenal46 2510.3PDGFRB, MB, MME
15naltrexone46 30 52 1212.2MME, ABCB1
16trifluoperazine46 30 52 1212.2ABCB1, MB
17phenylalanine469.1MME, PDGFRB, KIT
18acetylcholine46 52 30 25 1213.1DES, MME, MB
19enalapril46 52 1211.0ABCB1, MME
20ribonucleic acid469.0PDGFRB, MME, KIT
21cytarabine46 52 1211.0ABCB1, MME, KIT
22lactate469.0KIT, MME, MB, DES
23capecitabine46 52 1211.0PDGFRB, ABCB1, KIT
24pazopanib52 129.9KIT, PDGFRB, ABCB1
25sunitinib46 52 1210.9KIT, PDGFRB, ABCB1
26regorafenib52 129.9KIT, PDGFRB, ABCB1
27dasatinib46 52 1210.9ABCB1, KIT, PDGFRB
28erlotinib46 52 1210.9PDGFRB, ABCB1, KIT
29sorafenib46 52 1210.9KIT, ABCB1, PDGFRB
30gefitinib46 52 1210.9PDGFRB, ABCB1, KIT
31ketamine46 30 1210.9MB, ABCB1
32docetaxel46 52 62 1211.9ABCB1, PDGFRB, KIT
33h2o2468.8MME, MB, PDGFRB, DES
34methionine468.8DES, MME, PDGFRB, KIT
355fluorouracil468.8ABCB1, KIT, PDGFRB
36oxygen46 259.7MB, PDGFRB, DES, MME
37adriamycin468.7DES, ABCB1, MME, MB
38estrogen468.7KIT, MME, DES, PDGFRB
39retinoic acid46 259.6DES, MME, PDGFRB, KIT
40actinomycin d468.6KIT, DES, MME, ABCB1
41glucose468.6DES, PDGFRB, KIT, MME
42paclitaxel46 52 1210.6ABCB1, KIT, PDGFRB
43imatinib46 52 1210.5ABCB1, DES, PDGFRB, KIT
44paraffin468.4PDGFRB, DES, KIT, MB, MME
45vegf468.4MB, MME, KIT, PDGFRB, DES
46cysteine468.4MME, MB, DES, PDGFRB, KIT
47serine468.3MME, DES, MB, KIT, PDGFRB
48doxorubicin46 52 1210.2MB, DES, ABCB1, KIT, MME
49progesterone46 30 62 25 1212.0PDGFRB, MME, KIT, ABCB1, DES
50testosterone46 62 25 1210.6KIT, MB, PDGFRB, MME, DES, ABCB1

GO Terms for genes affiliated with Uterine Sarcoma

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17Gene Ontology
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Biological processes related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.4KIT, PDGFRB
2response to hydrogen peroxideGO:0425429.4MB, PDGFRB
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4KIT, PDGFRB
4peptidyl-tyrosine phosphorylationGO:0181089.3KIT, PDGFRB
5cell chemotaxisGO:0603269.2PDGFRB, KIT
6positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.0KIT, PDGFRB

Molecular functions related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3KIT, PDGFRB

Products for genes affiliated with Uterine Sarcoma

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  • Antibodies
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  • Lysates
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Sources for Uterine Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet