MCID: UTR043
MIFTS: 45

Uterine Sarcoma malady

Rare diseases, Cancer diseases categories

Summaries for Uterine Sarcoma

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Wikipedia:65 The uterine sarcomas form a group of malignant tumors that arises from the smooth muscle or connective... more...

MalaCards based summary: Uterine Sarcoma, also known as sarcoma of the uterus, is related to sarcoma and leiomyoma. An important gene associated with Uterine Sarcoma is DES (desmin), and among its related pathways are Hematopoietic cell lineage and Sorafenib Pharmacodynamics. The compounds toluidine and su6668 have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Uterine Sarcoma

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Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Uterine Sarcoma, Aliases & Descriptions:

Name: Uterine Sarcoma 43 45
Sarcoma of the Uterus 43 62
 
Uterine Corpus Sarcoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Uterine Sarcoma

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Diseases related to Uterine Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7MB, KIT, PDGFRB, DES, ABCB1
2leiomyoma30.8DES, MME, KIT
3alveolar soft-part sarcoma30.7MB
4endometrial stromal sarcoma30.2DES, MME, PDGFRB, KIT
5adenosarcoma30.1MB, MME, DES
6wilms tumor30.0ABCB1, DES, MME
7leiomyosarcoma30.0DES, MME, PDGFRB, KIT, MB
8uterine inversion10.6
9myeloid sarcoma10.3
10breast cancer10.2
11peritonitis10.2
12mast-cell sarcoma10.2
13cellular leiomyoma10.2
14vaginitis10.2
15splenomegaly10.2
16infantile myofibromatosis10.1DES
17carney triad10.0KIT
18myositis10.0MB
19myoma10.0
20uterine carcinosarcoma10.0
21adenocarcinoma10.0
22cervicitis10.0
23endometritis10.0
24placenta praevia10.0
25uterine fibroid10.0
26clostridium perfringens infection10.0
27cold agglutinin disease10.0
28endotheliitis10.0
29myelofibrosis10.0PDGFRB
30liposarcoma10.0DES, MB
31granular cell tumor10.0MB, DES
32rhabdomyosarcoma 2, alveolar10.0DES, MB
33embryonal rhabdomyosarcoma10.0DES, MB
34dedifferentiated liposarcoma10.0DES, KIT
35angiomyolipoma10.0KIT, DES
36neuromuscular disease10.0MB, DES
37phyllode tumor10.0KIT, MME
38duchenne muscular dystrophy10.0MB, DES
39sarcoma, synovial10.0KIT, DES
40chordoma10.0DES, PDGFRB
41factor vii deficiency10.0MB, KIT
42malignant fibroxanthoma10.0PDGFRB, DES
43hypereosinophilic syndrome, idiopathic, resistant to imatinib10.0KIT, PDGFRB
44systemic mastocytosis10.0PDGFRB, KIT
45precursor b-cell acute lymphoblastic leukemia10.0KIT, MME
46hypereosinophilic syndrome10.0PDGFRB, KIT
47oxyphilic adenoma10.0MME, KIT
48chronic myelomonocytic leukemia10.0KIT, PDGFRB
49mastocytosis10.0PDGFRB, KIT
50neurofibroma10.0KIT, PDGFRB

Graphical network of the top 20 diseases related to Uterine Sarcoma:



Diseases related to uterine sarcoma

Symptoms for Uterine Sarcoma

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Drugs & Therapeutics for Uterine Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Uterine Sarcoma

Search NIH Clinical Center for Uterine Sarcoma

Genetic Tests for Uterine Sarcoma

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Anatomical Context for Uterine Sarcoma

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MalaCards organs/tissues related to Uterine Sarcoma:

33
Uterus, Smooth muscle, Breast, Bone marrow, Bone, Brain, Colon, Placenta, Endothelial

Animal Models for Uterine Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Uterine Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2DES, PDGFRB, KIT, MB
2MP:00107687.6MB, KIT, PDGFRB, DES, ABCB1
3MP:00053857.5ABCB1, DES, PDGFRB, KIT, MB
4MP:00053767.1MB, KIT, PDGFRB, MME, DES, ABCB1

Publications for Uterine Sarcoma

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Articles related to Uterine Sarcoma:

(show top 50)    (show all 231)
idTitleAuthorsYear
1
Surgical Methods for the Treatment of Uterine Fibroids - Risk of Uterine Sarcoma and Problems of Morcellation: Position Paper of the DGGG. (25797958)
2015
2
Population-based estimates of the prevalence of uterine sarcoma among patients with leiomyomata undergoing surgical treatment. (25650751)
2015
3
Outcome analysis in patients with uterine sarcoma. (25874175)
2015
4
Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells. (24618889)
2014
5
Undifferentiated uterine sarcoma: a rare, not well known and aggressive disease: report of 13 cases. (24958349)
2014
6
Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. (24395448)
2014
7
Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. (22911740)
2012
8
Preface. Uterine sarcoma. (21764644)
2011
9
Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. (21734473)
2011
10
Uterine sarcoma: a rare cause of uterine inversion. (21982891)
2011
11
Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature. (20122944)
2010
12
Undifferentiated uterine sarcoma presenting as a pathologic humerus fracture. (20882934)
2010
13
Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. (20151639)
2010
14
Prognostic impact of parity in 493 uterine sarcoma patients. (19820369)
2009
15
Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma. (18308380)
2008
16
Uterine sarcoma: clinicopathological characteristics, treatment and outcome in Iran. (18990014)
2008
17
The management of patients with uterine sarcoma: a debated clinical challenge. (17706430)
2008
18
Huge uterine leiomyoma with adenomyotic cysts mimicking uterine sarcoma on MR imaging. (17450337)
2007
19
Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)
2006
20
Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)
2005
21
Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line. (15921732)
2005
22
Characteristics and management of uterine sarcoma patients treated at the Tom Baker Cancer Centre. (15670308)
2005
23
Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: a feasiblity study. (15675470)
2004
24
The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. (15491769)
2004
25
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. (12801270)
2003
26
Prognostic value of initial surgical procedure for patients with uterine sarcoma: analysis of 123 patients. (12807231)
2003
27
A spontaneous uterine sarcoma in a rhesus monkey (Macaca mulatta). (12450192)
2002
28
Prognostic factors and treatment modalities in uterine sarcoma. (12040283)
2002
29
Two patients with sarcoma. Case 2. Uterine sarcoma. (10829056)
2000
30
Cold agglutinin disease in a patient with uterine sarcoma. (11093691)
2000
31
Safety and efficacy of adjuvant single-agent ifosfamide in uterine sarcoma. (10926807)
2000
32
Uterine sarcoma: the Hacettepe hospital experience of 88 consecutive patients. (9105869)
1997
33
Uterine sarcoma: a clinicopathological study of 93 cases. (9174834)
1997
34
Uterine sarcoma. (8784887)
1996
35
Paraneoplastic retinopathy associated with uterine sarcoma. (7789878)
1995
36
Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. (8381710)
1993
37
Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma. (1326319)
1992
38
Establishment of human uterine sarcoma in nude mice. (2584825)
1989
39
Advanced uterine sarcoma; response to chemotherapy. (3383890)
1988
40
Adjuvant therapy for stage I uterine sarcoma. (3826216)
1987
41
Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. (3793549)
1986
42
Uterine sarcoma in Israel: a study of 104 cases. (4065710)
1985
43
Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). (3884128)
1985
44
Treatment of advanced uterine sarcoma with adriamycin. (6884822)
1983
45
Treatment of advanced uterine sarcoma with vincristine, actinomycin D, and cyclophosphamide. (6687580)
1983
46
Uterine sarcoma and policy of management. (7228094)
1980
47
Prophylactic chemotherapy in stages I and II uterine sarcoma. (511000)
1979
48
Stage III uterine sarcoma: case report and literature review. (378775)
1979
49
Clinical aspects and pathology of uterine sarcoma. (13779542)
1961
50
Uterine sarcoma simulating placenta praevia. (13385739)
1956

Variations for Uterine Sarcoma

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Expression for genes affiliated with Uterine Sarcoma

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Search GEO for disease gene expression data for Uterine Sarcoma.

Pathways for genes affiliated with Uterine Sarcoma

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Compounds for genes affiliated with Uterine Sarcoma

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Compounds related to Uterine Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1toluidine459.9DES, KIT
2su6668459.7PDGFRB, KIT
3zd6474459.7KIT, PDGFRB
4pkc 412459.7PDGFRB, KIT
5ag-1296459.7KIT, PDGFRB
6su5416459.7PDGFRB, KIT
7cilazapril45 1310.5MME, ABCB1
8nilotinib51 1310.5KIT, ABCB1
9lisinopril45 51 26 1312.4MME, ABCB1
10loperamide45 26 1311.4MME, ABCB1
11rhodamine 12345 5110.3KIT, ABCB1
12bromodeoxyuridine459.3DES, MME, PDGFRB
13ponatinib51 1310.3KIT, ABCB1
144-hydroxynonenal45 2610.3MB, PDGFRB, MME
15naltrexone45 30 51 1312.2ABCB1, MME
16trifluoperazine45 30 51 1312.2MB, ABCB1
17phenylalanine459.1MME, PDGFRB, KIT
18acetylcholine45 51 30 26 1313.1DES, MME, MB
19enalapril45 51 1311.0MME, ABCB1
20ribonucleic acid459.0KIT, PDGFRB, MME
21cytarabine45 51 1311.0KIT, MME, ABCB1
22lactate459.0DES, MME, KIT, MB
23capecitabine45 51 1311.0KIT, PDGFRB, ABCB1
24pazopanib51 139.9ABCB1, PDGFRB, KIT
25sunitinib45 51 1310.9KIT, PDGFRB, ABCB1
26regorafenib51 139.9ABCB1, PDGFRB, KIT
27dasatinib45 51 1310.9KIT, PDGFRB, ABCB1
28erlotinib45 51 1310.9KIT, PDGFRB, ABCB1
29sorafenib45 51 1310.9KIT, PDGFRB, ABCB1
30gefitinib45 51 1310.9KIT, PDGFRB, ABCB1
31ketamine45 30 1310.9MB, ABCB1
32docetaxel45 51 61 1311.9KIT, PDGFRB, ABCB1
33h2o2458.8DES, MME, PDGFRB, MB
34methionine458.8DES, MME, PDGFRB, KIT
355fluorouracil458.8KIT, PDGFRB, ABCB1
36oxygen45 269.7MB, PDGFRB, MME, DES
37adriamycin458.7ABCB1, DES, MME, MB
38estrogen458.7DES, MME, PDGFRB, KIT
39retinoic acid45 269.6DES, MME, PDGFRB, KIT
40actinomycin d458.6ABCB1, DES, MME, KIT
41glucose458.6DES, MME, PDGFRB, KIT
42paclitaxel45 51 1310.6KIT, PDGFRB, ABCB1
43imatinib45 51 1310.5ABCB1, DES, PDGFRB, KIT
44paraffin458.4MB, KIT, PDGFRB, MME, DES
45vegf458.4DES, MME, PDGFRB, KIT, MB
46cysteine458.4DES, MME, PDGFRB, KIT, MB
47serine458.3DES, MME, PDGFRB, KIT, MB
48doxorubicin45 51 1310.2ABCB1, DES, MME, KIT, MB
49progesterone45 30 61 26 1312.0ABCB1, DES, MME, PDGFRB, KIT
50testosterone45 61 26 1310.6MB, KIT, PDGFRB, MME, DES, ABCB1

GO Terms for genes affiliated with Uterine Sarcoma

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Biological processes related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:00108639.4KIT, PDGFRB
2response to hydrogen peroxideGO:00425429.4MB, PDGFRB
3positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4KIT, PDGFRB
4peptidyl-tyrosine phosphorylationGO:00181089.3KIT, PDGFRB
5cell chemotaxisGO:00603269.2PDGFRB, KIT
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.0KIT, PDGFRB

Molecular functions related to Uterine Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.3KIT, PDGFRB

Products for genes affiliated with Uterine Sarcoma

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Sources for Uterine Sarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet