MCID: UVT001
MIFTS: 67

Uveitis malady

Summaries for Uveitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Uveitis, also known as uveitis, nos, is related to posterior uveitis and intermediate uveitis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Influenza A. The drugs atropine and methylatropine nitrate and the compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uveitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

uveitis 8 10 44 60
uveitis, nos 8
uveitis nos 8


External Ids:

Disease Ontology8 DOID:13141
MeSH34 D014605
NCIt39 C26909

Related Diseases for Uveitis

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17GeneCards, 18GeneDecks
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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Intermediate Uveitis Anterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 480)
idRelated DiseaseScoreTop Affiliating Genes
1posterior uveitis31.3IL2RB, IL2RA, SAG
2intermediate uveitis31.2IL2RA, CXCR3, CCR5, CCR4
3retinitis31.1SAG
4arthritis31.1IL2RB, IL10, CXCL10, CXCR3, CXCR1, CD69
5ankylosing spondylitis30.7TNF
6vasculitis30.6RBP3, CTLA4, TNF, SAG, CCL2
7rheumatoid arthritis30.6IL2RB, IL10, IL2RA, CXCL10, CXCR3, CXCR1
8retinal vasculitis30.6SAG
9juvenile rheumatoid arthritis30.5IL2RB, IL2RA, LTA, TNF
10multiple sclerosis30.5IL2RB, IL10, IL2RA, CXCL10, CXCR3, CXCR1
11sarcoidosis30.5IL2RB, IL2RA, CXCL10, CXCR3, CD69, LTA
12endophthalmitis30.4SAG
13tuberculosis30.3IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
14behcet's disease30.3IL2RA, LTA, RBP3, CTLA4, TNF, SAG
15hypertension30.3CCL2
16encephalomyelitis30.3IL10, CXCL10, CXCR3, LTA, CTLA4, FASLG
17herpes simplex30.3CXCL10
18leukemia30.2IL2RB, IL2RA, CXCR3, CXCR1, LTA, FASLG
19pneumonia30.2IL2RB, IL10, CXCL10, TNF, CCL2
20optic neuritis30.2LTA
21psoriasis30.1IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
22inflammatory bowel disease30.1IL10, CXCL10, LTA, CTLA4, TNF, TNFRSF1A
23hepatitis30.1IL2RB, CXCL10, FASLG, FAS, TNFRSF1A
24vogt-koyanagi-harada disease30.1IL2RA, FASLG, FAS
25ulcerative colitis30.0IL10, IL2RA, CXCL10, CXCR3, CXCR1, LTA
26diabetes mellitus30.0CTLA4, TNF, TNFRSF1A, CCL2
27acquired immunodeficiency syndrome30.0CCR5, CCR2
28crohn's disease30.0TNF
29acute leukemia30.0CXCR1
30melanoma30.0IL2RB, IL10, CXCL10, CXCR3, CXCR1, CTLA4
31myeloid leukemia29.9LTA, FAS
32meningitis29.9CXCL10
33systemic lupus erythematosus29.8IL2RB, IL10, IL2RA, CXCL10, CXCR3, CD69
34graft versus host disease29.8IL2RB, IL10, IL2RA, LTA, CTLA4, FASLG
35hepatitis c29.8IL10, CXCL10, CXCR3, CD69, CTLA4, FAS
36breast cancer29.8CXCL10, CXCR3, CXCR1, CD69, CTLA4, FAS
37t-cell leukemia29.8IL2RB, IL2RA, LTA, FASLG, FAS, TNFRSF1A
38myasthenia gravis29.8IL10, LTA, CTLA4, IFNG, CCR5
39arthropathy29.8CXCL10, CD69, CTLA4, TNF
40thyroiditis29.8CTLA4, FASLG
41wegener's granulomatosis29.8CTLA4, CCR5
42psoriatic arthritis29.8TNF
43diabetic retinopathy29.8SAG
44hyperthyroidism29.8CTLA4
45eye disease29.8CCL2
46hypothyroidism29.8CTLA4
47graves' disease29.6IL2RA, CXCL10, CXCR3, CD69, LTA, CTLA4
48pulmonary sarcoidosis29.6IL2RB, IL2RA, CXCR3, LTA, TNF, IFNG
49influenza29.6IL2RB, CXCL10, CXCR3, CD69, LTA, IFNG
50prostate cancer29.6CXCL10, CXCR1, LTA, CTLA4, FASLG, FAS

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to uveitis

Clinical Features for Uveitis

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Drugs & Therapeutics for Uveitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Uveitis

Drug clinical trials:

Search ClinicalTrials for Uveitis

Search NIH Clinical Center for Uveitis

Search CenterWatch for Uveitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uveitis

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Anatomical Context for Uveitis

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32MalaCards
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MalaCards organs/tissues related to Uveitis:

32
Eye, T cells, Testes, Endothelial, Retina, Skin, Monocytes, Myeloid, Bone, Lung, Bone marrow, B cells, Prostate, Breast, Spleen, Brain, Pineal, Kidney, Liver, Thyroid, Spinal cord, Lymph node, Tongue, Nk cells

Animal Models for Uveitis or affiliated genes

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36MGI
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Publications for Uveitis

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50PubMed
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Articles related to Uveitis:

(show top 50)    (show all 1820)
idTitleAuthorsYear
1
Uveitis in HIV-infected persons with CD4+ T-lymphocyte count over 200 cells per microliter. (23777456)
2013
2
Acute anterior uveitis in Sydney. (23252660)
2013
3
Bilateral nongranulomatous uveitis with infective endocarditis. (23372383)
2013
4
Indirect supportive evidence for diagnosis of tuberculosis-related uveitis: from the tuberculin skin test to the new interferon gamma release assays. (23039176)
2013
5
Uveitis heralding previously unknown luetic and HIV infection. Syphilitic uveitis in an Italian referral center. (23771257)
2013
6
Golimumab treatment for complicated uveitis. (23331715)
2013
7
Surgical management in patient with uveitis. (23803480)
2013
8
25-gauge Vitrectomy for complicated chronic endogenous/autoimmune uveitis: predictors of outcomes. (23282088)
2013
9
Adalimumab therapy for refractory childhood uveitis. (24160962)
2013
10
Detection of ocular Toxoplasma gondii infection in chronic irregular recurrent uveitis by PCR. (22949751)
2012
11
Juvenile idiopathic arthritis-associated uveitis complicated by glaucoma and Brown's syndrome. (22491719)
2012
12
The effect of toll-like receptor 4 on macrophage cytokines during endotoxin induced uveitis. (22837708)
2012
13
Imaging in the diagnosis and management of uveitis. Preface. (22954954)
2012
14
Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis. (22509092)
2012
15
Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis. (22539790)
2012
16
Utility of QuantiFERONAr-TB Gold test in diagnosis and management of suspected tubercular uveitis in India. (22527447)
2012
17
CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis. (21531038)
2011
18
Pediatric infectious posterior uveitis. (21139480)
2011
19
Leptospirosis in a dog with uveitis and presumed cholecystitis. (22058365)
2011
20
JOVR Uveitis Issue; Partnership between European and Middle Eastern Ophthalmologists. (22454744)
2011
21
Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis. (20680102)
2010
22
Anterior uveitis and meningococcemia: a case report. (16766405)
2006
23
Anterior uveitis investigation by Canadian ophthalmologists: insights from the Canadian National Uveitis Survey. (17016528)
2006
24
Review of immunosuppressive drug therapy in uveitis. (15232467)
2004
25
Nephrogenic fibrosing dermopathy in a renal transplant recipient with tubulointerstitial nephritis and uveitis. (15237268)
2004
26
Type I collagen is the autoantigen in experimental autoimmune anterior uveitis. (15153531)
2004
27
Herpes zoster virus sclerokeratitis and anterior uveitis in a child following varicella vaccination. (12614776)
2003
28
Acute anterior uveitis. (15555118)
2003
29
HLA-B27-associated uveitis: overview and current perspectives. (14615643)
2003
30
With a mere nod, uveitis enters a new era. (14516815)
2003
31
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
32
Anterior ischaemic optic neuropathy in a patient with HLA-B27 associated anterior uveitis and ankylosing spondylitis. (11426425)
2001
33
Bilateral anterior uveitis associated with 0.3% minims metipranolol. (10624443)
1999
34
Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. (10535857)
1999
35
Pregnancy ameliorates induction and expression of experimental autoimmune uveitis. (10072507)
1999
36
Iris metastasis: an unusual cause of anterior uveitis. (8731712)
1996
37
Molecular genetics of posterior uveitis. (8964664)
1995
38
Laboratory investigations in posterior uveitis. (8964666)
1995
39
Anterior uveitis and diabetes mellitus: immunological study. (7746644)
1995
40
Granulomatous anterior uveitis presenting with acute posterior multifocal placoid pigment epitheliopathy. (7493536)
1995
41
Fuchs'heterochromic uveitis and Coats' disease. (22823119)
1994
42
Acute interstitial nephritis and anterior uveitis. (8018510)
1994
43
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
44
Serological evidence of an association between Lyme borreliosis and intermediate uveitis. (1730342)
1992
45
Intermediate uveitis: epidemiology, age and sex distribution. (1730379)
1992
46
Systemic associations of anterior uveitis. (1879997)
1991
47
Molecular size of retinal vascular leakage determined by FITC-dextran angiography in patients with posterior uveitis. (1720745)
1991
48
Tropical myositis with pleuropericardial effusion and anterior uveitis. (2380141)
1990
49
A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy. (2596540)
1989
50
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982

Genetic Variations for Uveitis

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Expression for genes affiliated with Uveitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for genes affiliated with Uveitis

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51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.0CXCL10, CXCR3, LTA, TNF, TNFRSF1A, CCL2
2
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10.9CCL2, IFNG, TNFRSF1A, TNF, FAS, FASLG
3
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10.9IL2RA, CCR4, CCR2, CXCL10, CXCR3, CXCR1
4
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10.9IFNG, TNFRSF1A, TNF, FAS, FASLG, CTLA4
5
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10.9CCR4, CCR2, CCR5, CCL2, SAG, RBP3
6
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10.9IL2RB, IL2RA, CXCL10, CXCR3, LTA, TNFRSF1A
7
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10.9IFNG, TNFRSF1A, TNF, FAS, FASLG, IL2RA
8
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10.8CCL2, IFNG, TNFRSF1A, TNF, FAS, FASLG
9
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10.8CCR5, CCL2, TNFRSF1A, TNF, FAS, FASLG
10
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10.8CCR4, CCR2, CCR5, LTA, CXCR3, CXCL10
1110.8CCR4, CCR2, CCR5, CCL2, CXCR1, CXCR3
12
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10.8CCR4, CCR2, CCR5, CCL2, CXCR1, CXCR3
13
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10.8CCR4, CCR2, CCR5, CCL2, CXCR1, CXCR3
14
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10.8CCR5, IFNG, TNF, FAS, CTLA4, IL10
1510.8CCR2, FAS, FASLG, IL2RA, IL10, IL2RB
1610.8CCL2, TNFRSF1A, TNF, FAS, LTA, CXCL10
17
Hide members
10.7CCR4, CCR2, CCR5, CCL2, CXCR3, CXCL10
1810.7IFNG, TNF, FASLG, IL2RA, IL2RB
19
Hide members
10.7IFNG, TNF, FASLG, CTLA4, IL2RA
2010.7IFNG, TNF, FAS, FASLG, IL10
21
Hide members
10.7CCR5, IFNG, FASLG, IL2RA, IL2RB
22
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10.7IFNG, TNFRSF1A, TNF, IL2RA, IL2RB
23
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10.7CCR5, IFNG, TNFRSF1A, TNF, LTA
24
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10.7IL2RB, IL2RA, LTA, TNF, TNFRSF1A
25
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10.7IFNG, TNFRSF1A, TNF, FAS, FASLG
26
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10.7LTA, FASLG, FAS, TNF, TNFRSF1A
27
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10.7TNFRSF1A, TNF, FAS, FASLG, LTA
28
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10.7TNFRSF1A, TNF, FAS, FASLG, LTA
29
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10.7IL2RB, IL2RA, LTA, TNFRSF1A, CCL2
30
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10.7IFNG, TNF, LTA, IL10
3110.7IL10, LTA, TNF, IFNG
32
Immune response Bacterial infections in normal airways
10.7IFNG, TNF, FAS, FASLG
3310.7IL2RB, IL10, IL2RA, IFNG
34
Development PDGF signaling via STATs and NF-kB
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10.7CCL2, IFNG, TNF, IL10
35
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10.7IFNG, TNFRSF1A, TNF, LTA
36
Hide members
10.7FASLG, LTA, IL2RA, IL2RB
3710.7CCR2, CCL2, IFNG, TNF
3810.7IFNG, TNFRSF1A, IL2RA, IL2RB
39
Hide members
10.7CCR4, CCR5, CXCR1, CXCR3
40
Signal transduction JNK pathway
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10.7FASLG, FAS, TNF, TNFRSF1A
41
Hide members
10.7TNFRSF1A, TNF, FAS, FASLG
42
Apoptosis and survival Apoptotic TNF-family pathways
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10.7TNFRSF1A, TNF, FAS, FASLG
43
Apoptosis and survival Caspase cascade
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10.7TNFRSF1A, TNF, FAS, FASLG
4410.7CCR2, CCL2, TNF, CXCL10
4510.6IL10, LTA, IFNG
4610.6LTA, TNF, TNFRSF1A
4710.6IL10, TNF, TNFRSF1A
4810.6TNFRSF1A, IL2RA, IL2RB
49
Hide members
10.5CCR5
5010.5CTLA4

Compounds for genes affiliated with Uveitis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 181)
idCompoundScoreTop Affiliating Genes
1vegf4411.5IL10, CXCL10, CXCR3, CXCR1, CCL2, TNFRSF1A
2nitric oxide44 11 2413.5IFNG, CD69, LTA, FASLG, RBP3, CCL2
3tyrosine4411.5SAG, IL2RB, IL2RA, CXCR3, CXCR1, CXCL10
4il 104411.4IL2RB, IL10, IL2RA, CCR5, CCL2, IFNG
5ionomycin4411.4CD69, IL2RA, IL10, IL2RB, LTA, CTLA4
6infliximab44 49 1113.4IFNG, TNFRSF1A, TNF, FAS, CTLA4, LTA
7tacrolimus44 49 1113.4IFNG, TNF, FASLG, CTLA4, CD69, CXCR3
8retinoic acid44 2412.4CCR4, TNFRSF1A, TNF, FASLG, RBP3, LTA
9rantes4411.4FASLG, IL2RB, IL2RA, CXCR3, CXCR1, LTA
10thymidine44 2412.4CD69, IFNG, TNF, FAS, FASLG, IL2RB
11calcium44 49 11 2414.4CCL2, CXCL10, CCR5, CCR2, IL2RB, CCR4
12ccl344 2812.3CXCR3, CXCL10, IL10, CXCR1, TNF, CCR4
13tarc4411.3CCR4, CCR5, CCL2, IFNG, TNF, CXCR1
14actinomycin d4411.3CCL2, CCR5, IFNG, TNFRSF1A, TNF, FAS
15genistein44 28 59 2 11 2416.3FAS, FASLG, TNF, IFNG, CCL2, CD69
16okt34411.3IL2RA, IL10, IL2RB, LTA, FAS, IFNG
17phosphatidylinositol4411.3FAS, TNFRSF1A, CCL2, FASLG, IL2RB, CD69
18herbimycin a44 5912.3CXCR1, IL2RA, CD69, FAS, CCL2, IFNG
19ifn-alpha4411.3IFNG, FAS, FASLG, CXCR3, CXCL10, IL2RA
20neopterin4411.3CXCL10, TNFRSF1A, IL2RA, LTA, IL2RB, IL10
21cyclosporin a44 28 5913.2IFNG, SAG, CTLA4, LTA, CD69, IL2RA
22histamine44 28 2413.2CCL2, IFNG, CCR5, TNF, CXCR3, CXCL10
23tgf beta14411.2TNF, CCL2, FAS, IL10, TNFRSF1A, FASLG
24simvastatin44 49 59 28 11 2416.2FASLG, TNF, CCR5, IL10, CCL2, IFNG
25groalpha4411.2CXCL10, CXCR1, CXCR3, IL10, CCL2, CCR5
26etanercept44 49 1113.2IFNG, TNFRSF1A, TNF, CXCR3, IL10, LTA
27paraffin4411.2TNFRSF1A, FAS, FASLG, LTA, IL2RA, IL10
28dexamethasone44 49 28 1114.2CTLA4, FASLG, FAS, LTA, CXCR1
29ivig4411.2CCR5, IFNG, SAG, TNFRSF1A, IL2RB
30thalidomide44 49 59 1114.2FASLG, TNF, IL10, IFNG, TNFRSF1A, IL2RA
31methotrexate44 49 1113.1TNFRSF1A, TNF, IL2RB, IL10, IL2RA, FASLG
32cycloheximide4411.1FASLG, RBP3, LTA, CXCL10, IL2RB
33vitamin d4411.1IL2RA, IL10, CCR5, CXCL10, LTA, FAS
34con a4411.1IFNG, IL10, IL2RB, CD69, IL2RA, CTLA4
35endotoxin4411.1TNFRSF1A, FASLG, CXCR3
36lipid4411.0CXCL10, CXCR1, LTA, CTLA4, TNF, IL2RB
37prednisolone44 28 1113.0IL2RA, CCR4, IL2RB, LTA
38rapamycin4411.0CCR5, IFNG, FAS, FASLG, CTLA4, IL2RA
39serine4411.0CTLA4, CXCR3, IL2RB, CCR5, CCL2, TNFRSF1A
40ly2940024411.0FASLG, CTLA4, CCL2, CD69, CXCR3, TNF
41allergens4411.0IFNG, IL10, CXCL10, CXCR3, CD69, CTLA4
422,5-oligoadenylate4411.0IL2RB, IL2RA, CXCL10, TNF
43pge24410.9SAG
44aspartate4410.9CCL2, SAG, FASLG, IL2RB, CCR5
45pentoxifylline44 1111.9IL2RB, LTA
46fmlp4410.8CXCR3, CD69
47morphine44 49 28 1113.8CCR5, SAG, FAS, CXCL10, IL2RB, FASLG
48rs 5043935910.7CCR4, CCR2, CCR5, CXCR1
49sb 22500259 2811.6CCR2, CCR5, CXCR1, CCR4
50sb 2656105910.4CCR4, CCR2, CCR5, CXCR1

GO Terms for genes affiliated with Uveitis

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16Gene Ontology
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Cellular components related to Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989711.1IL2RB, CD69, CCR4, CXCR3, CXCL10, FASLG
2plasma membraneGO:00588611.0CCR5, IL2RB, IL2RA, CXCR1, CTLA4, FAS
3integral to plasma membraneGO:00588710.9CTLA4, CCR2, CCR5, TNFRSF1A, TNF, FASLG
4extracellular spaceGO:00561510.8CCL2, IFNG, TNFRSF1A, TNF, RBP3, LTA
5extracellular regionGO:00557610.5RBP3, CXCL10, CCL2, TNFRSF1A, TNF, IFNG

Biological processes related to Uveitis according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4IL10, CCR4, CCR2, CCR5, CCL2, TNFRSF1A
2cell surface receptor signaling pathwayGO:00716611.3CCR5, CCL2, IFNG, SAG, CXCR1, CXCR3
3apoptotic processGO:00691511.3IFNG, TNFRSF1A, TNF, FAS, FASLG, LTA
4chemotaxisGO:00693511.2CCR4, CCR2, CCR5, CCL2, CXCR1, CXCR3
5immune responseGO:00695511.2CCR4, CCR2, CCR5, FASLG, CTLA4, CXCL10
6positive regulation of apoptotic processGO:04306511.2TNF, FAS, FASLG, CTLA4, LTA, IL2RA
7chemokine-mediated signaling pathwayGO:07009811.1CCR4, CCR2, CCR5, CCL2, CXCR1
8cell-cell signalingGO:00726711.1CCR5, FASLG, LTA, CXCL10, IL10
9negative regulation of growth of symbiont in hostGO:04413011.1IFNG, TNF, LTA, IL10
10cytokine-mediated signaling pathwayGO:01922111.1CCR2, CCL2, IFNG, TNFRSF1A, IL2RB
11response to drugGO:04249311.1CCL2, IFNG, TNF, LTA, IL10
12extrinsic apoptotic signaling pathway via death domain receptorsGO:00862511.1TNFRSF1A, TNF, FAS, FASLG
13humoral immune responseGO:00695911.1LTA, TNF, IFNG, CCL2
14response to glucocorticoid stimulusGO:05138411.1CCL2, TNF, FAS, IL10
15negative regulation of angiogenesisGO:01652511.1CCR2, CCL2, FASLG, CXCL10
16cellular response to lipopolysaccharideGO:07122211.1CCR5, CCL2, IFNG, IL10
17elevation of cytosolic calcium ion concentrationGO:00720411.1CCR4, CCR2, CCR5, CXCR3
18apoptotic signaling pathwayGO:09719011.0TNFRSF1A, TNF, FAS, FASLG
19dendritic cell chemotaxisGO:00240711.0CXCR1, CCR5, CCR2
20negative regulation of interleukin-6 productionGO:03271511.0IL10, TNF, TNFRSF1A
21response to lipopolysaccharideGO:03249611.0CXCL10, LTA, FASLG, TNFRSF1A
22response to activityGO:01482311.0IL10, TNF, CCL2
23response to hypoxiaGO:00166611.0CCL2, TNFRSF1A, TNF, LTA
24positive regulation of interferon-gamma productionGO:03272911.0CCR2, TNF, LTA
25positive regulation of vitamin D biosynthetic processGO:06055710.9IFNG, TNF
26positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.9CCR2, CCL2
27positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9TNF, LTA
28inflammatory cell apoptotic processGO:00692510.9FAS, FASLG
29calcium-mediated signalingGO:01972210.9CXCR3, TNF, CCR5
30receptor biosynthetic processGO:03280010.9IL10, TNF
31activation of necroptosis by extracellular signalsGO:06055510.9FASLG, TNF
32positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9TNF, IFNG
33regulation of vascular endothelial growth factor productionGO:01057410.9CCL2, CCR2
34necrotic cell deathGO:07026510.9TNF, FASLG
35negative regulation of cytokine secretion involved in immune responseGO:00274010.9TNF, IL10
36positive regulation of necrotic cell deathGO:01094010.8TNF, FAS
37MAPK cascadeGO:00016510.8TNF, CCL2, CCR5
38activation-induced cell death of T cellsGO:00692410.8FAS, IL2RA
39positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA
40positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
41transformed cell apoptotic processGO:00692710.8TNF, FAS
42positive regulation of chemokine biosynthetic processGO:04508010.7TNF, IFNG
43activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7FASLG, FAS, TNF
44positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.7IFNG, TNFRSF1A
45signal transductionGO:00716510.7CCL2, FAS, FASLG, LTA, CXCL10, IL2RB
46regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.6FAS, FASLG
47positive regulation of synaptic transmissionGO:05080610.6TNF, CCL2
48cellular homeostasisGO:01972510.3CCL2, CCR2

Molecular functions related to Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.9CXCR3, CXCR1, CCR5, CCR2, CCR4
2cytokine activityGO:00512510.9IFNG, TNF, FASLG, LTA, IL10
3C-C chemokine receptor activityGO:01649310.7CCR5, CCR2, CCR4
4tumor necrosis factor receptor bindingGO:00516410.7TNF, FASLG, LTA
5receptor bindingGO:00510210.7CXCL10, LTA, FASLG, CCL2
6CCR2 chemokine receptor bindingGO:03172710.6CCR2, CCL2
7interleukin-2 bindingGO:01997610.5IL2RA, IL2RB
8interleukin-2 receptor activityGO:00491110.3IL2RA, IL2RB

Products for genes affiliated with Uveitis

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  • Antibodies
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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet