MCID: UVT001
MIFTS: 61

Uveitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Uveitis

MalaCards integrated aliases for Uveitis:

Name: Uveitis 12 72 28 51 41 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13141
ICD10 32 H20.9
MeSH 41 D014605
NCIt 46 C26909
UMLS 69 C0042164

Summaries for Uveitis

MalaCards based summary : Uveitis is related to posterior uveitis and fuchs' heterochromic uveitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluocinolone Acetonide and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 564)
# Related Disease Score Top Affiliating Genes
1 posterior uveitis 33.8 CAPN5 IFNG IL2RA RBP3 SAG TNF
2 fuchs' heterochromic uveitis 33.3 IL2RA TGFB2
3 intermediate uveitis 33.1 CXCR3 HLA-B IFNG IL10 IL2RA TNF
4 anterior uveitis 33.1 CTLA4 HLA-B IL2RA TNF
5 multifocal choroiditis 32.2 IL10 TNF
6 vitreoretinopathy, neovascular inflammatory 32.2 CAPN5 CCL2 TGFB2
7 panuveitis 32.1 HLA-B IL10 IL17A RBP3 SAG TNF
8 tropical spastic paraparesis 31.3 CXCR3 HLA-B IFNG IL10 IL2RA
9 cytomegalovirus retinitis 30.9 HLA-B IFNG TNF
10 spondyloarthropathy 1 30.8 HLA-B IL17A NOD2 TNF
11 spondylitis 30.8 HLA-B IL17A NOD2 TNF
12 scleritis 30.6 CCL2 IL4 TNF
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.4 CTLA4 IFNG IL10 IL17A
14 vogt-koyanagi-harada disease 30.3 HLA-B IL10 IL17A IL2RA
15 vasculitis 30.3 CCL2 ICAM1 IFNA2 TNF
16 crohn's disease 30.2 IFNG IL10 NOD2 TNF
17 herpes zoster 30.2 IFNA2 IFNG IL10
18 arthritis 30.2 CCL2 IFNG IL10 IL17A IL1A NOD2
19 juvenile rheumatoid arthritis 30.2 IL1R1 IL2RA TNF
20 q fever 30.2 IFNG IL10 TNF
21 ulcerative colitis 30.0 IFNG IL10 NOD2 TNF
22 rubella 30.0 HLA-B IL10 IL4 TNF
23 neuritis 30.0 CCL2 IFNG IL4 TNF
24 meningitis 29.9 CCL2 IFNG IL10 TNF
25 reactive arthritis 29.9 HLA-B IFNG IL10 IL17A TNF
26 toxoplasmosis 29.9 IFNG IL10 IL4 TNF
27 conjunctivitis 29.9 ICAM1 IFNG IL4
28 stromal keratitis 29.9 CCL2 IL17A IL2RA TNF
29 chlamydia 29.9 IFNG IL10 TNF
30 helicobacter pylori infection 29.8 IFNG IL10 TNF
31 kawasaki disease 29.8 CCL2 IL10 TNF
32 spotted fever 29.8 IFNG IL10 TNF
33 leptospirosis 29.7 CCL2 IL10 TNF
34 central nervous system vasculitis 29.7 IFNG IL17A TNF
35 oligoarticular juvenile idiopathic arthritis 29.7 CXCR3 IL2RA TNF
36 spondyloarthropathy 29.6 HLA-B IFNG IL10 IL17A IL4 TNF
37 keratoconjunctivitis 29.6 ICAM1 IFNG IL4 TNF
38 keratoconjunctivitis sicca 29.6 IL1A IL4 TNF
39 graft-versus-host disease 29.6 HLA-B IFNG IL10 IL1A TNF
40 herpes simplex virus keratitis 29.6 CCL2 ICAM1
41 allergic conjunctivitis 29.5 ICAM1 IFNG IL4
42 mycobacterium tuberculosis 1 29.5 CXCR3 IFNG IL10 IL17A IL4 TNF
43 extrapulmonary tuberculosis 29.5 CCL2 IFNG IL10 IL1A
44 hepatitis c 29.5 IFNA2 IFNG IL10 TNF
45 chronic graft versus host disease 29.5 IFNG IL10 IL1A IL2RA
46 psoriatic arthritis 29.5 HLA-B IL17A IL1A NOD2 TNF
47 acquired immunodeficiency syndrome 29.4 HLA-B IFNA2 IFNG IL10 IL2RA TNF
48 mastitis 29.4 ICAM1 IL17A NOD2
49 candidiasis 29.4 IFNG IL10 IL17A
50 aphthous stomatitis 29.3 HLA-B IL10 IL4 TNF

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to Uveitis

Symptoms & Phenotypes for Uveitis

GenomeRNAi Phenotypes related to Uveitis according to GeneCards Suite gene sharing:

25 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.33 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.33 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.33 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.33 IL1R1 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.33 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.33 IL1R1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.33 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.33 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.33 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.33 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.33 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.33 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.33 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.33 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.33 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.33 IFNA2 IL1R1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.33 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.33 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.33 IFNA2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.33 IL1R1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.33 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.33 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.33 IL1R1 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.33 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.33 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.33 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.33 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.33 IFNA2 IL1R1 IL10 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.33 IFNA2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.33 IL2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.33 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.33 IL2RA IL10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.33 IL10 IL2RA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.33 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.33 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.33 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.33 IL1R1 IL2RA
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.33 IL1R1
39 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 TNF IL2RA NOD2 IL10 ICAM1 IL17A
40 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 TNF IL2RA NOD2 IL10 ICAM1 IL17A

MGI Mouse Phenotypes related to Uveitis:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 NOD2 IL2RA TGFB2 IL4 IL1A IL1R1
2 homeostasis/metabolism MP:0005376 10.28 IL1R1 NOD2 SAG IL2RA TGFB2 IL4
3 immune system MP:0005387 10.27 NOD2 IL2RA TGFB2 IL4 IL1A IL1R1
4 growth/size/body region MP:0005378 10.23 NOD2 IL1R1 IL2RA IL17A IL4 TGFB2
5 digestive/alimentary MP:0005381 10.19 NOD2 IL2RA TGFB2 IL4 TNF ICAM1
6 endocrine/exocrine gland MP:0005379 10.18 IL1R1 IL2RA IL17A IL4 TGFB2 TNF
7 mortality/aging MP:0010768 10.17 IL1R1 NOD2 IL2RA IL17A IL4 TGFB2
8 craniofacial MP:0005382 10.05 IL1R1 IL17A IL4 TGFB2 TNF IL10
9 respiratory system MP:0005388 9.85 IL2RA TGFB2 IL4 IL1R1 TNF IL17A
10 neoplasm MP:0002006 9.8 IL1R1 IL1A TNF CXCR3 IL10 ICAM1
11 skeleton MP:0005390 9.61 NOD2 IL1R1 IL17A IL4 TGFB2 TNF
12 vision/eye MP:0005391 9.32 IL1R1 RBP3 SAG IL2RA TGFB2 IL4

Drugs & Therapeutics for Uveitis

Drugs for Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 248)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
4
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
7
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
8
Apraclonidine Approved Phase 4 66711-21-5 2216
9
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
10
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
11
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
12
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
13
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
14
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
15
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 90-82-4 7028
16
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
17
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
18
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 46507594 772
19
Adalimumab Approved Phase 4,Phase 2,Phase 3,Phase 1 331731-18-1 16219006
20
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
21
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
22
Chlorambucil Approved Phase 4 305-03-3 2708
23
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
24
Daclizumab Approved, Investigational Phase 4,Phase 2,Phase 1 152923-56-3
25
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
26
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
27
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
28
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
29
Timolol Approved Phase 4,Phase 3 26839-75-8 5478 33624
30
Travoprost Approved Phase 4 157283-68-6 5282226
31
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
32
Certolizumab pegol Approved Phase 4 428863-50-7
33
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
36
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
37
Lactitol Investigational Phase 4 585-86-4 3871
38
Maleic acid Experimental Phase 4 110-16-7 444266
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
45 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Phase 1
46 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Phase 1
47 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Phase 1
48 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
49 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
50 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 361)

# Name Status NCT ID Phase Drugs
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
2 Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema Unknown status NCT02598869 Phase 4 Triamcinolone Acetonide
3 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
5 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Unknown status NCT01827722 Phase 4 Ozurdex;Ranibizumab;Combination Ozurdex with Ranibizumab PRN
6 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4
7 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Unknown status NCT02684084 Phase 4 Ozurdex;Lucentis
8 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
9 Multi Center Prospective Registry of Infliximab Use for Childhood Uveitis Completed NCT00589628 Phase 4 infliximab;infliximab
10 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
11 Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Completed NCT00543296 Phase 4 0.59 mg Fluocinolone Acetonide implant
12 Corneal Specular Microscopy in Infectious and Noninfectious Uveitis Completed NCT00789984 Phase 4
13 TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema Completed NCT01870440 Phase 4 Ozurdex Intravitreal Injection (0.7 mg)
14 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4 Prednisolone acetate
15 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
16 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
17 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
18 Steroids After Laser Trabeculoplasty for Glaucoma Completed NCT00981435 Phase 4 Prednisolone 1%;Diclofenac 0.1%;Artificial Tears
19 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4 Hydroxypropylmethylcellulose;Carboxymethylcellulose
20 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4 ranibizumab
21 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
22 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
23 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
24 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
25 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Recruiting NCT02769702 Phase 4 Acthar
26 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
27 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
28 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
29 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
30 Topical Treatment for Uveitic Macular Edema Not yet recruiting NCT01939691 Phase 4 Difluprednate 0.05% ophthalmic emulsion;Nepafenac 0.1% ophthalmic solution;Prednisolone acetate 1% ophthalmic suspension
31 Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density Not yet recruiting NCT03361709 Phase 4 Dexamethasone;Saline Solutions, Intraocular
32 PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial Suspended NCT02374060 Phase 4 Periocular triamcinolone 40 mg;Intravitreal triamcinolone 4 mg;Dexamethasone intravitreal implant
33 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4 Thalidomide
34 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4 Methotrexate;Placebo
35 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
36 Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial) Unknown status NCT00348153 Phase 2, Phase 3 Adalimumab
37 The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis Unknown status NCT00012506 Phase 3 TNFR:Fc
38 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
39 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
40 Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema Unknown status NCT01523314 Phase 2, Phase 3 dexamethasone - Cyclodextrin eye drops
41 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
42 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
43 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3 ranibizumab
44 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
45 Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
46 First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial Completed NCT01232920 Phase 3 Methotrexate;Mycophenolate mofetil
47 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
48 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
49 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
50 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3 LX211

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: uveitis

Genetic Tests for Uveitis

Genetic tests related to Uveitis:

# Genetic test Affiliating Genes
1 Uveitis 28

Anatomical Context for Uveitis

MalaCards organs/tissues related to Uveitis:

38
Eye, T Cells, Endothelial, Retina, Testes, Skin, Neutrophil

Publications for Uveitis

Articles related to Uveitis:

(show top 50) (show all 2310)
# Title Authors Year
1
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
2
Association of genetic variants in<i>RAB23</i>and<i>ANXA11</i>with uveitis in sarcoidosis. ( 29416296 )
2018
3
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
4
A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis. ( 29435587 )
2018
5
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
6
Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )
2018
7
Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis. ( 29420111 )
2018
8
Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. ( 29370567 )
2018
9
Editorial: Uveitis: Pathology, Molecular Mechanisms and Therapy. ( 29424309 )
2018
10
The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). ( 29429748 )
2018
11
Anterior uveitis. ( 29290458 )
2018
12
Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III. ( 29429764 )
2018
13
Mesenchymal stem cells inhibited dendritic cells via the regulation of STAT1 and STAT6 phosphorylation in experimental autoimmune uveitis. ( 29424313 )
2018
14
Role of CT Chest and Cytology in Differentiating Tuberculosis from Presumed Sarcoidosis in Uveitis. ( 29420114 )
2018
15
Risk Factors for Development of Rhegmatogenous Retinal Detachment in Patients with Uveitis. ( 29420113 )
2018
16
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
17
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
18
Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report. ( 29452449 )
2018
19
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
20
An Intraocular Inflammatory Profile of Rubella Associated Uveitis. ( 29370571 )
2018
21
Late-onset postoperative Mycobacterium haemophilum endophthalmitis masquerading as inflammatory uveitis: a case report. ( 29415658 )
2018
22
Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis). ( 29427823 )
2018
23
Relapse of Juvenile Idiopathic Arthritis-Associated Uveitis after Discontinuation of Immunomodulatory Therapy. ( 29451845 )
2018
24
Presumed tuberculous uveitis in a university-based tertiary referral center in Saudi Arabia. ( 29318438 )
2018
25
Macular Edema in Childhood Uveitis. ( 29452454 )
2018
26
Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )
2018
27
Granulomatous Tattoo reaction with Associated Uveitis successfully treated with methotrexate. ( 29419907 )
2018
28
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
29
Management of Uveitis in Spondyloarthropathy: Current Trends. ( 29272246 )
2018
30
How to deal with uveitis patients? ( 29424311 )
2018
31
Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment. ( 28862736 )
2017
32
MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats. ( 29434444 )
2017
33
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
34
Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice. ( 28914568 )
2017
35
Functional Conversion and Dominance of I^I' T Subset in Mouse Experimental Autoimmune Uveitis. ( 28069804 )
2017
36
Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography. ( 28973324 )
2017
37
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017
38
Acute Bilateral Anterior Uveitis after a Single Intravenous Infusion of Zoledronic Acid in Metastatic Breast Cancer. ( 28682020 )
2017
39
Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )
2017
40
Fibrinous anterior uveitis and recurrent epithelial erosion following topical tetracaine abuse. ( 28521706 )
2017
41
Amblyopia due to intermediate uveitis as the presenting symptom of Crohn's disease in a 6-year-old boy. ( 29102673 )
2017
42
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. ( 28195080 )
2017
43
Phacoemulsification and Core Vitrectomy in Fuchs' Heterochromic Uveitis. ( 28638250 )
2017
44
Cataract surgery in uveitis: a multicentre database study. ( 28043984 )
2017
45
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
46
Epidemiological profile of patients with uveitis in Boko and Parakou, in northern BAcnin. ( 28947410 )
2017
47
Patterns of Intermediate Uveitis in Children Presenting at a Tertiary Eye Care Center in South India. ( 28936054 )
2017
48
Successful ustekinumab treatment of noninfectious uveitis and concomitant severe psoriatic arthritis and plaque psoriasis. ( 28833973 )
2017
49
Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis. ( 29354718 )
2017
50
Demographic and Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in Iran. ( 29422760 )
2017

Variations for Uveitis

Expression for Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for Uveitis

Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CCL2 CTLA4 HLA-B ICAM1 IFNA2 IFNG
2
Show member pathways
13.91 CAPN5 CCL2 CXCR3 IL10 IL17A IL1A
3
Show member pathways
13.73 CCL2 CXCR3 IFNA2 IFNG IL10 IL17A
4
Show member pathways
13.61 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
5
Show member pathways
13.51 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
6
Show member pathways
13.39 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
7
Show member pathways
13.36 CCL2 HLA-B ICAM1 IFNA2 IFNG IL10
8
Show member pathways
13.04 CCL2 IFNA2 IL1A IL1R1 NOD2 TNF
9
Show member pathways
12.88 CCL2 HLA-B ICAM1 IFNA2 IFNG IL1A
10
Show member pathways
12.74 CTLA4 HLA-B ICAM1 IFNA2 IFNG IL10
11
Show member pathways
12.69 IFNG IL10 IL2RA IL4 TNF
12
Show member pathways
12.66 CCL2 IFNG IL10 IL17A TNF
13
Show member pathways
12.65 CCL2 IFNA2 IFNG IL10 TGFB2 TNF
14
Show member pathways
12.64 HLA-B ICAM1 IFNA2 TGFB2 TNF
15
Show member pathways
12.63 HLA-B ICAM1 IFNA2 IFNG IL4 TNF
16 12.62 CCL2 CTLA4 IFNG IL10 IL17A IL2RA
17
Show member pathways
12.56 IFNG IL10 IL17A IL1A IL1R1 IL2RA
18 12.55 HLA-B ICAM1 IL1R1 IL2RA TGFB2 TNF
19
Show member pathways
12.53 CTLA4 IFNG IL10 IL17A IL1A IL4
20
Show member pathways
12.47 IFNA2 IFNG IL10 IL2RA IL4
21
Show member pathways
12.44 CCL2 ICAM1 IFNG IL4 TNF
22
Show member pathways
12.43 CCL2 IFNG IL17A IL4 TNF
23
Show member pathways
12.37 IFNG IL10 IL1A IL4 TGFB2 TNF
24
Show member pathways
12.35 CCL2 IL1A IL1R1 NOD2
25 12.35 HLA-B ICAM1 IFNG IL10
26 12.34 IFNA2 IFNG IL10 IL1A NOD2 TGFB2
27
Show member pathways
12.33 IFNG IL1A IL1R1 TNF
28
Show member pathways
12.28 IFNA2 IFNG IL1A TNF
29
Show member pathways
12.25 IFNG IL1R1 IL4 TNF
30 12.2 CCL2 ICAM1 IFNG IL1A IL1R1 TNF
31
Show member pathways
12.18 HLA-B IFNA2 IFNG IL10 IL17A IL1A
32 12.17 IFNG IL1A IL1R1 TGFB2 TNF
33 12.13 CCL2 ICAM1 IFNG IL1A IL1R1 IL4
34 12.11 IFNA2 IFNG IL10 IL2RA IL4 TNF
35 12.1 CCL2 ICAM1 IL10 IL17A IL1A IL4
36
Show member pathways
12.07 IFNG IL1R1 IL2RA IL4
37 12.05 CCL2 ICAM1 NOD2 TNF
38 12.04 CCL2 ICAM1 IL1A TGFB2 TNF
39
Show member pathways
12.03 IFNG IL10 IL17A TNF
40 12.03 IL1A IL1R1 IL2RA IL4 TNF
41 12.02 IFNG IL10 IL1R1 TGFB2 TNF
42
Show member pathways
11.99 IFNG IL17A IL1R1 IL4 TGFB2
43 11.93 IFNA2 IFNG IL10 IL2RA
44
Show member pathways
11.88 CTLA4 IFNG IL2RA IL4 TNF
45 11.87 IFNA2 IFNG IL10 TNF
46 11.85 IFNG TGFB2 TNF
47 11.84 ICAM1 IFNG IL4
48 11.8 IL10 IL1A TNF
49
Show member pathways
11.79 ICAM1 IFNG IL1A TNF
50 11.77 CTLA4 ICAM1 IL10 IL2RA IL4 TGFB2

GO Terms for Uveitis

Cellular components related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
2 cell surface GO:0009986 9.56 CAPN5 CXCR3 HLA-B ICAM1 IL1R1 IL2RA
3 external side of plasma membrane GO:0009897 9.17 CTLA4 CXCR3 ICAM1 IL17A IL1R1 IL2RA
4 extracellular region GO:0005576 10 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.96 IFNA2 IFNG TGFB2 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 CCL2 ICAM1 NOD2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.91 CCL2 IFNA2 IL1A IL1R1
4 cellular response to lipopolysaccharide GO:0071222 9.86 CCL2 ICAM1 IL10 TNF
5 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 NOD2 TNF
6 cellular response to interleukin-1 GO:0071347 9.85 CCL2 ICAM1 IL17A
7 regulation of inflammatory response GO:0050727 9.84 IL1R1 NOD2 TNF
8 interferon-gamma-mediated signaling pathway GO:0060333 9.84 HLA-B ICAM1 IFNG
9 B cell differentiation GO:0030183 9.83 IFNA2 IL10 IL4
10 cell surface receptor signaling pathway GO:0007166 9.8 CCL2 CXCR3 IFNA2 IFNG IL1R1 IL2RA
11 positive regulation of interleukin-6 production GO:0032755 9.79 IL1A NOD2 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG TNF
13 extrinsic apoptotic signaling pathway GO:0097191 9.77 IFNG TGFB2 TNF
14 inflammatory response GO:0006954 9.76 CCL2 CXCR3 IFNA2 IL10 IL17A IL1A
15 negative regulation of T cell proliferation GO:0042130 9.74 CTLA4 IL10 IL2RA
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 ICAM1 IL10 IL4
18 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
19 positive regulation of cytokine secretion GO:0050715 9.65 IL10 IL1A TNF
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
23 type 2 immune response GO:0042092 9.62 IL10 IL4
24 humoral immune response GO:0006959 9.62 CCL2 IFNA2 IFNG TNF
25 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
26 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG IL17A TNF
27 regulation of receptor activity GO:0010469 9.61 CCL2 IFNA2 IFNG IL10 IL17A IL1A
28 positive regulation of neutrophil extravasation GO:2000391 9.58 IL1A IL1R1
29 regulation of isotype switching GO:0045191 9.58 IL10 IL4
30 negative regulation of immune response GO:0050777 9.58 CTLA4 IL2RA TGFB2
31 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
33 regulation of regulatory T cell differentiation GO:0045589 9.54 CTLA4 IFNG IL2RA
34 regulation of complement-dependent cytotoxicity GO:1903659 9.52 IL10 TGFB2
35 negative regulation of alkaline phosphatase activity GO:0010693 9.51 TGFB2 TNF
36 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 IFNG TNF
37 immune response GO:0006955 9.36 CCL2 CTLA4 HLA-B IFNG IL10 IL17A
38 apoptotic process GO:0006915 10.12 CXCR3 IFNA2 IFNG IL17A IL1A IL2RA

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Sources for Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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