MCID: UVT001
MIFTS: 65

Uveitis malady

Eye diseases, Rare diseases categories
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Summaries for Uveitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Uveitis is related to posterior uveitis and intermediate uveitis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Cellular Transformation by HTLV1 and Inflammatory Response Pathway. The drugs atropine and methylatropine nitrate and the compounds natalizumab and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are no phenotypic analysis and integument.

Aliases & Classifications for Uveitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

uveitis 8 10 45 62


External Ids:

Disease Ontology8 DOID:13141
MeSH35 D014605
NCIt40 C26909

Related Diseases for Uveitis

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17GeneCards, 18GeneDecks
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Diseases in the Intermediate Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
uveitis Anterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 440)
idRelated DiseaseScoreTop Affiliating Genes
1posterior uveitis31.5SAG, IL2RA, IL2RB
2intermediate uveitis31.3IL2RA, CCR5, CXCR3
3arthritis30.9TNF, CXCR3, CXCR1, CCR5, IFNG, IL2RB
4retinal vasculitis30.8SAG
5vasculitis30.7RBP3, SAG, TNF
6blau syndrome30.7TNF
7juvenile rheumatoid arthritis30.6TNF, IL2RA, IL2RB, LTA
8endophthalmitis30.6SAG
9chorioretinitis30.5SAG, RBP3
10sarcoidosis30.4TNF, CXCR3, CCR5, IFNG, IL2RA, IL2RB
11pneumonia30.4IL10, IL2RB, TNF
12tuberculosis30.3TNF, SAG, CXCR3, CXCR1, IFNG, IL2RA
13behcet's disease30.3TNF, SAG, CCR5, IL2RA, RBP3, LTA
14rheumatoid arthritis30.3LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
15hepatitis30.2LTA, IL2RB, FASLG
16encephalomyelitis30.2TNF, FASLG, CXCR3, CCR5, IFNG, IL10
17inflammatory bowel disease30.2TNF, CCR5, IFNG, IL10, LTA
18vogt-koyanagi-harada disease30.1FAS, FASLG, IL2RA
19multiple sclerosis30.1LTA, IL10, IL2RB, FASLG, SAG, CXCR3
20psoriasis30.1TNF, CXCR3, CXCR1, IFNG, IL2RA, IL10
21thyroiditis30.0FASLG
22leukemia30.0TNF, FAS, FASLG, CXCR3, CXCR1, IFNG
23ulcerative colitis29.9TNF, CXCR3, CXCR1, IFNG, IL2RA, IL10
24myasthenia gravis29.9CCR5, IFNG, IL10, LTA
25hepatitis c29.8IL10, IFNG, CCR5, CXCR3, FAS
26t-cell leukemia29.8FAS, FASLG, IL2RA, IL2RB, LTA
27psoriatic arthritis29.8TNF
28hodgkin's lymphoma29.7LTA, IL2RB, IL2RA
29mycosis fungoides29.7CXCR3, CXCR1, IL2RA, IL2RB
30eosinophilia29.7IFNG, IL2RA, IL2RB, IL10
31chronic lymphocytic leukemia29.7CXCR3, CCR5, IL2RA, LTA
32melanoma29.7TNF, FAS, FASLG, SAG, CXCR3, CXCR1
33non-hodgkin lymphoma29.7IL2RB, IL2RA, FAS
34autoimmune lymphoproliferative syndrome29.6FAS, FASLG, IL2RA, IL10
35influenza29.6CXCR3, CCR5, IFNG, IL2RB, LTA
36graft versus host disease29.6LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
37systemic lupus erythematosus29.5LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
38prostate cancer29.5FAS, FASLG, CXCR1, CCR5, LTA
39graves' disease29.5FAS, FASLG, CXCR3, CCR5, IFNG, IL2RA
40anterior uveitis11.1
41nephritis10.8
42retinitis10.8
43tubulointerstitial nephritis and uveitis10.8
44hypopyon10.6
45ankylosing spondylitis10.5
46spondylitis10.5
47glaucoma10.5
48tuberculous uveitis10.5
49cystoid macular edema10.5
50cataract10.5

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to uveitis

Symptoms for Uveitis

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Drugs & Therapeutics for Uveitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Uveitis

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Uveitis

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Anatomical Context for Uveitis

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33MalaCards
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MalaCards organs/tissues related to Uveitis:

33
Eye, T cells, Testes, Endothelial, Retina, Skin, Monocytes, Myeloid, Bone, Lung, Bone marrow, B cells, Prostate, Breast, Spleen, Brain, Pineal, Kidney, Liver, Thyroid, Spinal cord, Lymph node, Tongue, Nk cells

Animal Models for Uveitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Uveitis:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6IL10, IFNG, CCR5, CCR2, TNF
2MP:00107717.9TNF, FAS, FASLG, IFNG, IL2RB, IL10
3MP:00053677.9FAS, FASLG, CXCR3, CCR2, IFNG
4MP:00053797.9TNF, FAS, FASLG, IFNG, IL2RB, IL10
5MP:00053907.7TNF, FAS, FASLG, CCR2, IFNG, IL10
6MP:00053897.7TNF, FAS, FASLG, CCR5, IFNG, IL2RB
7MP:00053887.5TNF, FAS, FASLG, CXCR3, CCR2, IFNG
8MP:00053817.4TNF, FAS, FASLG, CCR2, CCR5, IFNG
9MP:00053787.4TNF, FAS, CCR2, IFNG, IL2RA, IL2RB
10MP:00020067.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
11MP:00053867.4TNF, FAS, CCR2, CCR5, IFNG, IL2RB
12MP:00053847.2TNF, FAS, FASLG, CXCR3, CCR2, CCR5
13MP:00053707.0TNF, FAS, FASLG, CCR2, CCR5, IFNG
14MP:00053857.0TNF, FAS, FASLG, CXCR3, CCR2, CCR5
15MP:00053766.9TNF, FAS, FASLG, CXCR3, CCR2, CCR5
16MP:00053976.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
17MP:00053876.4CXCR3, FASLG, FAS, TNF, CCR2, CCR5
18MP:00107686.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
19MP:00053916.3LTA, TNF, FAS, FASLG, SAG, CCR2
20MP:00036316.2SAG, FASLG, FAS, TNF, CCR2, CCR5

Publications for Uveitis

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52PubMed
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Articles related to Uveitis:

(show top 50)    (show all 1802)
idTitleAuthorsYear
1
Anterior chamber intraocular lens implantation in patients with a history of chronic uveitis: Five-year follow-up. (24238942)
2014
2
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
3
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
4
Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. (23062650)
2013
5
Response of pediatric uveitis to tumor necrosis factor-I+ inhibitors. (23818712)
2013
6
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. (23676143)
2013
7
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
8
The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. (24204112)
2013
9
Expression changes and novel interaction partners of talin 1 in effector cells of autoimmune uveitis. (24144192)
2013
10
Circulating anti-nuclear antibodies in uveitis. (23698221)
2013
11
Infectious causes of posterior uveitis and panuveitis in Thailand. (22539102)
2012
12
Follow-up of erlotinib related uveitis. (22892235)
2012
13
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
14
The role of biologic agents in the management of non-infectious uveitis. (22780091)
2012
15
Brimonidine (Alphagan) associated anterior uveitis. (22257785)
2012
16
Qingkailing injection alleviates experimental autoimmune uveitis in rats via inhibiting Th1 and Th17 effector cells. (23123470)
2012
17
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
18
Mucoepidermoid carcinoma as a masquerade syndrome of scleral melting and granulomatous kerato-uveitis. (21484645)
2011
19
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. (21836350)
2011
20
Uveitis in Blau syndrome from a de novo mutation of the NOD2/CARD15 gene. (21596301)
2011
21
CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome. (21976957)
2011
22
Autofluorescence in posterior uveitis. (20689208)
2010
23
Intravitreal infliximab in experimental endotoxin-induced uveitis. (19787603)
2009
24
Recent advances in studies of clinical treatment of uveitis]. (19176129)
2008
25
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
26
Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor. (18469182)
2008
27
Retrospective analysis of children with uveitis treated with infliximab. (18930672)
2008
28
Bilateral acute anterior uveitis as a side effect of trimethoprim. (16751748)
2007
29
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
30
Intermediate uveitis. (16282148)
2005
31
Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. (16280979)
2005
32
Recurrent uveitis in a patient with juvenile spondyloarthropathy associated with tumour necrosis factor alpha inhibitors. (12480683)
2003
33
Acute anterior uveitis. (15366165)
2003
34
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
35
Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN-gamma production and the function of dendritic cells. (12869029)
2003
36
Diagnosis and management of herpetic anterior uveitis. (12189614)
2002
37
Hypopyon uveitis. (11525785)
2001
38
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
39
Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma. (19078330)
1998
40
Whipple's syndrome (uveitis, B27-negative spondylarthropathy, meningitis, and lymphadenopathy) associated with Arthrobacter sp. infection. (9787360)
1998
41
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
42
Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen--first results. (9232451)
1997
43
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
44
Molecular genetics of posterior uveitis. (8964664)
1995
45
Laboratory investigations in posterior uveitis. (8964666)
1995
46
Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. (8172275)
1994
47
Humoral and cellular immune responses to retinal S-antigen in uveitis patients]. (8223034)
1993
48
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
49
Experimental autoimmune posterior uveitis accompanied by epitheloid cell accumulations (EAPU). A new type of experimental ocular disease induced by immunization with PEP-65, a pigment epithelial polypeptide preparation. (1486940)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Uveitis

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Expression for genes affiliated with Uveitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for genes affiliated with Uveitis

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50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 12EMD Millipore, 54R&D Systems, 55Reactome, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TNF, IFNG, LTA
29.6IFNG, IL2RA, IL2RB
3
Show member pathways
IL-2 Signaling pathway38
9.6IFNG, IL2RA, IL2RB
49.5IL10, IFNG, TNF
59.5TNF, IFNG, IL10
69.5TNF, IFNG, IL10
79.4LTA, IL10, IFNG
89.4IFNG, FASLG, TNF
99.4IFNG, CCR2, TNF
109.4IFNG, CCR2, TNF
119.4CXCR3, CXCR1, CCR5
12
Show member pathways
Peptide GPCRs38
9.4CCR5, CXCR1, CXCR3
13
Show member pathways
9.3IL2RB, IL2RA, IFNG, TNF
14
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3LTA, IL2RB, IL2RA, TNF
159.3LTA, IL2RB, IL2RA, TNF
169.3TNF, FAS, LTA
179.2TNF, IFNG, IL10, LTA
18
Show member pathways
IL27-mediated signaling events38
9.2TNF, IFNG, IL10, LTA
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.2TNF, FASLG, IFNG, IL2RA
20
Show member pathways
Type III interferon signaling38
9.2IFNG, IL2RA, IL2RB, IL10
21
Show member pathways
9.1LTA, IFNG, CCR5, TNF
229.1IL2RB, IL2RA, CCR5, CXCR1
239.1TNF, FAS, FASLG
24
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.1TNF, FAS, FASLG
25
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.1FASLG, FAS, TNF
26
Show member pathways
9.1FASLG, FAS, TNF
27
Show member pathways
9.1IL10, IFNG, CCR5, TNF
28
Show member pathways
IL2 signaling events mediated by STAT538
9.0FASLG, IL2RA, IL2RB, LTA
29
Show member pathways
8.9CXCR3, CXCR1, CCR2, CCR5
30
Show member pathways
8.9CXCR3, CXCR1, CCR2, CCR5
31
Show member pathways
Ras signaling in the CD4+ TCR pathway38
8.8TNF, FASLG, IFNG, IL2RA, IL2RB
32
Show member pathways
Immune response CD16 signaling in NK cells60
8.8TNF, FAS, FASLG, IFNG
33
Show member pathways
8.7LTA, FASLG, FAS, TNF
34
Show member pathways
8.7TNF, FAS, FASLG, LTA
35
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.7LTA, FASLG, FAS, TNF
36
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.6FASLG, CCR5, IFNG, IL2RA, IL2RB
37
Show member pathways
8.6TNF, IFNG, IL2RA, IL2RB, IL10, LTA
38
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.5TNF, FAS, CCR5, IFNG, IL10
39
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5LTA, IFNG, FASLG, FAS, TNF
40
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.4TNF, FAS, FASLG, IFNG, IL10
418.4TNF, FAS, FASLG, IFNG, IL10
42
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.3TNF, FAS, FASLG, CCR5, LTA
43
Show member pathways
7.8TNF, FAS, FASLG, IFNG, IL2RA, IL2RB
44
Show member pathways
7.8TNF, FAS, FASLG, IFNG, IL2RA, IL10
457.8FAS, FASLG, CCR2, IL2RA, IL2RB, IL10
46
Show member pathways
7.8IL10, IL2RB, IL2RA, IFNG, FASLG, FAS
47
Show member pathways
7.6TNF, CXCR3, CCR2, CCR5, IL2RA, IL2RB
48
Show member pathways
7.6TNF, LTA, IL10, IL2RB, IL2RA, CCR5
49
Show member pathways
7.6IL10, IL2RB, IL2RA, CCR5, CCR2, CXCR3
50
Show member pathways
5.8LTA, TNF, FAS, FASLG, IL10, IL2RB

Compounds for genes affiliated with Uveitis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1natalizumab45 1110.6IFNG, IL10, IL2RA, TNF
2interferon gamma459.5IFNG, IL10, TNF
3ccl11299.4CXCR3, CCR2, CCR5
4con a459.4IFNG, IL2RA, IL10, IL2RB
5ccl13299.4CXCR3, CCR2, CCR5
6ccl7299.4CCR5, CXCR3, CCR2
7imiquimod45 61 29 1112.3TNF, FASLG, IFNG, IL10
82,5-oligoadenylate459.3TNF, IFNG, IL2RB, IL2RA, IL10
9groalpha459.1IL10, CCR5, CXCR1, CXCR3, TNF
10thalidomide45 51 61 1112.1IFNG, FASLG, TNF, IL10, IL2RA
11mycophenolate mofetil45 51 1111.0IFNG, LTA, IL10, IL2RB, IL2RA, TNF
12pentoxifylline45 1110.0IL10, IL2RB, TNF, LTA, IFNG, IL2RA
13neopterin459.0IL2RA, IL2RB, IFNG, LTA, IL10, TNF
14etanercept45 51 1110.9IL2RB, IL10, LTA, IFNG, TNF, CXCR3
15tarc458.9IFNG, CXCR3, IL10, CCR5, TNF, CXCR1
16ccl345 299.9IL10, IFNG, CCR5, CXCR1, CXCR3, TNF
17calcitriol45 61 24 1111.8LTA, IL2RA, IL10, IFNG, TNF
18herbimycin a45 619.8TNF, CXCR1, LTA, IL2RA, IFNG, FAS
19ribavirin45 51 1110.7IL10, CXCR3, CCR5, IFNG
20methotrexate51 45 1110.7TNF, FASLG, IL2RA, IL10, IL2RB
21simvastatin45 51 61 29 24 1113.7FASLG, IFNG, CCR5, IL10, TNF
22indomethacin45 29 61 1111.5IL2RA, LTA, FAS, FASLG, IFNG, TNF
23morphine45 51 29 1111.5FASLG, FAS, IL2RB, CCR5, SAG
24histamine45 29 2410.5IL10, CXCR3, IL2RB, IL2RA, IFNG, CCR5
25tgf beta1458.5FASLG, FAS, LTA, IL10, TNF
26tacrolimus45 51 1110.5FASLG, CXCR3, TNF, IL2RA, IFNG, IL2RB
27okt3458.4LTA, IL10, IL2RB, IFNG, FAS, TNF
28prednisolone45 29 1110.4FAS, IFNG, IL2RA, IL2RB, IL10, LTA
29il 10458.2TNF, LTA, IL10, IL2RB, IL2RA, IFNG
30genistein45 29 61 3 24 1113.2FAS, FASLG, CXCR1, IL2RB, TNF, IFNG
31paraffin458.1FAS, IL10, IL2RA, SAG, LTA, FASLG
32ifn-alpha458.1FASLG, CXCR3, IFNG, IL2RA, IL2RB, IL10
33endotoxin458.1CXCR1, CXCR3, IFNG, IL10, IL2RB, FASLG
34infliximab45 51 1110.1FAS, IL10, IL2RB, IL2RA, IFNG, CXCR3
35actinomycin d458.0CCR5, LTA, TNF, IFNG, CXCR1, FAS
36rapamycin457.9FASLG, CCR5, IFNG, IL2RA, IL2RB, IL10
37aspartate457.9CCR5, SAG, FASLG, IL2RB, IL10, IL2RA
38ionomycin457.9IFNG, IL2RA, FASLG, FAS, TNF, LTA
39thymidine45 248.8CXCR3, FASLG, TNF, FAS, IFNG, IL2RA
40butyrate457.8FASLG, TNF, FAS, CCR5, IFNG, RBP3
41pge2457.5LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
42rantes457.4FAS, FASLG, CXCR3, CXCR1, CCR5, IFNG
43tyrosine457.3FASLG, SAG, CXCR3, CXCR1, IL2RA, IL2RB
44vegf457.2LTA, IL10, IL2RA, IFNG, CXCR1, CXCR3
45cyclosporin a45 29 619.1LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
46ivig457.1IL2RA, LTA, IL10, IL2RB, IFNG, CCR5
47cycloheximide457.0LTA, IL2RB, RBP3, IL10, TNF, IFNG
48nitric oxide45 24 118.9RBP3, IL2RB, IL10, LTA, IFNG, CXCR3
49retinoic acid45 247.9CXCR1, FASLG, IL2RB, RBP3, CCR5, LTA
50dexamethasone45 51 29 119.8TNF, FAS, FASLG, CXCR3, CXCR1, CCR5

GO Terms for genes affiliated with Uveitis

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16Gene Ontology
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Cellular components related to Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7TNF, FASLG, IFNG, IL10, RBP3, LTA
2integral component of plasma membraneGO:0058877.7TNF, FASLG, CXCR3, CCR2, CCR5, IL2RB
3external side of plasma membraneGO:0098977.4IL2RB, TNF, FAS, FASLG, CXCR3, CCR5
4plasma membraneGO:0058867.4FAS, CXCR3, CXCR1, CCR2, CCR5, IL2RA

Biological processes related to Uveitis according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:06055710.4TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, TNF
3positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.3TNF, LTA
4positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, TNF
5positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.2LTA, TNF
6receptor biosynthetic processGO:03280010.2IL10, TNF
7negative regulation of cytokine secretion involved in immune responseGO:00274010.2IL10, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:05104410.2TNF, IFNG
9positive regulation of osteoclast differentiationGO:04567210.1IFNG, TNF
10positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10
11protein import into nucleus, translocationGO:00006010.1IFNG, TNF
12negative regulation of interleukin-6 productionGO:03271510.0TNF, IL10
13activation-induced cell death of T cellsGO:00692410.0IL2RA, FAS
14humoral immune responseGO:00695910.0LTA, IFNG, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.9TNF, IFNG
16positive regulation of cytokine secretionGO:0507159.9IL10, TNF
17transformed cell apoptotic processGO:0069279.9TNF, FAS
18response to activityGO:0148239.9IL10, TNF
19defense response to Gram-positive bacteriumGO:0508309.9LTA, TNF
20calcium-mediated signalingGO:0197229.8CCR5, CXCR3, TNF
21positive regulation of interferon-gamma productionGO:0327299.8TNF, CCR2, LTA
22positive regulation of monocyte chemotaxisGO:0900269.8CCR2, CCR5
23inflammatory cell apoptotic processGO:0069259.7FAS, FASLG
24negative regulation of T cell proliferationGO:0421309.7IL2RA, IL10
25cellular response to lipopolysaccharideGO:0712229.7CCR5, IFNG, IL10
26negative regulation of growth of symbiont in hostGO:0441309.6TNF, IFNG, IL10, LTA
27dendritic cell chemotaxisGO:0024079.6CCR5, CCR2, CXCR1
28chemokine-mediated signaling pathwayGO:0700989.6CCR5, CCR2, CXCR1
29regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.6FAS, FASLG
30response to glucocorticoidGO:0513849.5IL10, FAS, TNF
31response to drugGO:0424939.5TNF, IFNG, IL10, LTA
32necroptotic signaling pathwayGO:0975279.5TNF, FAS, FASLG
33negative regulation of angiogenesisGO:0165259.5FASLG, CXCR3, CCR2
34extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5FASLG, FAS, TNF
35positive regulation of cytosolic calcium ion concentrationGO:0072049.5CCR5, CCR2, CXCR3
36activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4FASLG, FAS, TNF
37apoptotic signaling pathwayGO:0971909.3FASLG, FAS, TNF
38chemotaxisGO:0069359.3CXCR3, CXCR1, CCR2, CCR5
39extrinsic apoptotic signaling pathwayGO:0971919.2IFNG, FASLG, FAS, TNF
40cell-cell signalingGO:0072679.1FASLG, CCR5, IL10, LTA
41positive regulation of apoptotic processGO:0430659.1TNF, FAS, FASLG, LTA
42cell surface receptor signaling pathwayGO:0071669.0IL2RA, IFNG, CCR5, CXCR1, CXCR3, SAG
43immune responseGO:0069559.0FASLG, CCR2, CCR5, IL2RA
44cytokine-mediated signaling pathwayGO:0192219.0IL2RB, IFNG, CCR2
45inflammatory responseGO:0069548.6TNF, CXCR3, CXCR1, CCR2, CCR5, IL10
46apoptotic processGO:0069158.3TNF, FAS, FASLG, CXCR3, IFNG, IL2RA

Molecular functions related to Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.6IL2RB, IL2RA
3C-C chemokine receptor activityGO:0164939.5CCR5, CCR2
4tumor necrosis factor receptor bindingGO:0051649.4TNF, FASLG, LTA
5chemokine receptor activityGO:0049509.0CCR5, CCR2, CXCR1, CXCR3
6cytokine activityGO:0051258.7TNF, FASLG, IFNG, IL10, LTA

Products for genes affiliated with Uveitis

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Sources for Uveitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet