MCID: UVT001
MIFTS: 67

Uveitis malady

Summaries for Uveitis

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Uveitis, also known as uveitis, nos, is related to posterior uveitis and intermediate uveitis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Influenza A. The drugs atropine and methylatropine nitrate and the compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uveitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
See all sources

Aliases & Descriptions:

uveitis 8 10 44 60
uveitis, nos 8
uveitis nos 8


External Ids:

Disease Ontology8 DOID:13141
MeSH34 D014605
NCIt39 C26909

Related Diseases for Uveitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Intermediate Uveitis Anterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 480)
idRelated DiseaseScoreTop Affiliating Genes
1posterior uveitis31.3IL2RB, IL2RA, SAG
2intermediate uveitis31.2IL2RA, CXCR3, CCR5, CCR4
3retinitis31.1SAG
4arthritis31.1IL2RB, IL10, CXCL10, CXCR3, CXCR1, CD69
5ankylosing spondylitis30.7TNF
6vasculitis30.6RBP3, CTLA4, TNF, SAG, CCL2
7rheumatoid arthritis30.6IL2RB, IL10, IL2RA, CXCL10, CXCR3, CXCR1
8retinal vasculitis30.6SAG
9juvenile rheumatoid arthritis30.5IL2RB, IL2RA, LTA, TNF
10multiple sclerosis30.5IL2RB, IL10, IL2RA, CXCL10, CXCR3, CXCR1
11sarcoidosis30.5IL2RB, IL2RA, CXCL10, CXCR3, CD69, LTA
12endophthalmitis30.4SAG
13tuberculosis30.3IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
14behcet's disease30.3IL2RA, LTA, RBP3, CTLA4, TNF, SAG
15hypertension30.3CCL2
16encephalomyelitis30.3IL10, CXCL10, CXCR3, LTA, CTLA4, FASLG
17herpes simplex30.3CXCL10
18leukemia30.2IL2RB, IL2RA, CXCR3, CXCR1, LTA, FASLG
19pneumonia30.2IL2RB, IL10, CXCL10, TNF, CCL2
20optic neuritis30.2LTA
21psoriasis30.1IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
22inflammatory bowel disease30.1IL10, CXCL10, LTA, CTLA4, TNF, TNFRSF1A
23hepatitis30.1IL2RB, CXCL10, FASLG, FAS, TNFRSF1A
24vogt-koyanagi-harada disease30.1IL2RA, FASLG, FAS
25ulcerative colitis30.0IL10, IL2RA, CXCL10, CXCR3, CXCR1, LTA
26diabetes mellitus30.0CTLA4, TNF, TNFRSF1A, CCL2
27acquired immunodeficiency syndrome30.0CCR5, CCR2
28crohn's disease30.0TNF
29acute leukemia30.0CXCR1
30melanoma30.0IL2RB, IL10, CXCL10, CXCR3, CXCR1, CTLA4
31myeloid leukemia29.9LTA, FAS
32meningitis29.9CXCL10
33systemic lupus erythematosus29.8IL2RB, IL10, IL2RA, CXCL10, CXCR3, CD69
34graft versus host disease29.8IL2RB, IL10, IL2RA, LTA, CTLA4, FASLG
35hepatitis c29.8IL10, CXCL10, CXCR3, CD69, CTLA4, FAS
36breast cancer29.8CXCL10, CXCR3, CXCR1, CD69, CTLA4, FAS
37t-cell leukemia29.8IL2RB, IL2RA, LTA, FASLG, FAS, TNFRSF1A
38myasthenia gravis29.8IL10, LTA, CTLA4, IFNG, CCR5
39arthropathy29.8CXCL10, CD69, CTLA4, TNF
40thyroiditis29.8CTLA4, FASLG
41wegener's granulomatosis29.8CTLA4, CCR5
42psoriatic arthritis29.8TNF
43diabetic retinopathy29.8SAG
44hyperthyroidism29.8CTLA4
45eye disease29.8CCL2
46hypothyroidism29.8CTLA4
47graves' disease29.6IL2RA, CXCL10, CXCR3, CD69, LTA, CTLA4
48pulmonary sarcoidosis29.6IL2RB, IL2RA, CXCR3, LTA, TNF, IFNG
49influenza29.6IL2RB, CXCL10, CXCR3, CD69, LTA, IFNG
50prostate cancer29.6CXCL10, CXCR1, LTA, CTLA4, FASLG, FAS

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to uveitis

Clinical Features for Uveitis

About this section

Drugs & Therapeutics for Uveitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uveitis

Drug clinical trials:

Search ClinicalTrials for Uveitis

Search NIH Clinical Center for Uveitis

Search CenterWatch for Uveitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uveitis

About this section

Anatomical Context for Uveitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Uveitis:

32
Eye, T cells, Testes, Endothelial, Retina, Skin, Monocytes, Myeloid, Bone, Lung, Bone marrow, B cells, Prostate, Breast, Spleen, Brain, Pineal, Kidney, Liver, Thyroid, Spinal cord, Lymph node, Tongue, Nk cells

Animal Models for Uveitis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Uveitis

About this section
Sources:
50PubMed
See all sources

Articles related to Uveitis:

(show top 50)    (show all 1820)
idTitleAuthorsYear
1
Cryptic Uveitis in a Patient with Morning Glory Syndrome. (24143921)
2013
2
Light on the horizont: biologicals in BehAset uveitis. (22520021)
2013
3
Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis: primary 6-month results of the SAVE Study. (23514595)
2013
4
Effects of Japanese herbal medicine Sairei-to on murine experimental autoimmune uveitis. (24126677)
2013
5
Trends in patterns of anterior uveitis in a tertiary institution in singapore. (23617304)
2013
6
Topiramate-induced angle-closure glaucoma: cross-sensitivity with other sulphonamide derivatives causing anterior uveitis. (23749237)
2013
7
Neoplastic Masquerade Syndromes in Patients With Uveitis. (24211361)
2013
8
Overview and recent developments in the medical management of paediatric uveitis. (23826652)
2013
9
Chinese medicine in the treatment of Behcet's disease's uveitis: a case report. (22466948)
2012
10
Mycophenolate mofetil use in the treatment of noninfectious uveitis. (22517204)
2012
11
Imaging retinal vascular changes in uveitis. (22954931)
2012
12
Leptospiral uveitis - there is more to it than meets the eye! (22958257)
2012
13
Whipple disease with crystalline keratopathy and chronic uveitis. (22965603)
2012
14
Cataract surgery in uveitis. (22518338)
2012
15
Error in figure in "intravitreal ketorolac for chronic uveitis and macular edema: a pilot study". (23753681)
2012
16
Relapsing uveitis and optic neuritis due to chronic Q fever. (20733024)
2011
17
Risk of relapse in primary acute anterior uveitis. (21680024)
2011
18
Optic neuritis associated with adalimumab in the treatment of uveitis. (20809867)
2010
19
Bilateral uveitis with hypopyon as a presenting symptom of metastatic peritoneal carcinomatosis. (20099238)
2010
20
Labrafil--a new adjuvant for peptide-specific oral tolerance in rat experimental autoimmune uveitis. (18042397)
2008
21
Distinct cytokine patterns in the aqueous humor of children, adolescents and adults with uveitis. (19065415)
2008
22
Th1 and Th2 responses on the ocular surface in uveitis identified by CCR4 and CCR5 conjunctival expression. (18222196)
2008
23
Use of tumor necrosis factor inhibitors in uveitis. (17762615)
2007
24
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
25
Diagnostic ophthalmology. Anterior uveitis, cataract, retinal detachment, and an intraocular foreign body. (17966343)
2007
26
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. (17496900)
2007
27
Favorable response to high-dose infliximab for refractory childhood uveitis. (16545455)
2006
28
Interferon alfa-2a: a new treatment option for long lasting refractory cystoid macular edema in uveitis? A pilot study. (16963852)
2006
29
Intermediate uveitis. (16282148)
2005
30
Long-term treatment of refractory posterior uveitis with anti-TNFalpha (infliximab). (15389273)
2005
31
Effects of pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, on cytokine expression and ocular inflammation in experimental autoimmune anterior uveitis. (15857275)
2005
32
Anterior uveitis in a child with Takayasu's arteritis. (15180852)
2004
33
Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN-gamma production and the function of dendritic cells. (12869029)
2003
34
Posterior uveitis: an under-recognized adverse effect of pamidronate: 2 case reports. (14750233)
2003
35
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
36
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
37
Bilateral non-specific orbital inflammation (orbital "pseudotumour"), posterior scleritis, and anterior uveitis associated with hypothyroidism in a child. (12140225)
2002
38
Evaluation of therapeutic effectiveness using MR imaging in a rabbit model of anterior uveitis. (12076092)
2002
39
Validation of a diagnostic multiplex polymerase chain reaction assay for infectious posterior uveitis. (11545637)
2001
40
Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele. (11935433)
2001
41
Uveitis in Herpes zoster ophthalmicus. (11778812)
2001
42
Importance of cryptic myelin basic protein epitopes in the pathogenicity of acute and recurrent anterior uveitis associated with EAE. (11164904)
2001
43
Immune responses to retinal autoantigens and peptides in equine recurrent uveitis. (11157872)
2001
44
Hypopyon uveitis and iris nodules in non-Hodgkin's lymphoma: ocular relapse during systemic remission. (11315712)
2000
45
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
46
Herpes simplex anterior uveitis. (10081730)
1998
47
Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. (8172275)
1994
48
Diseases masquerading intermediate uveitis. (1730373)
1992
49
Secondary syphilis presenting with optic perineuritis and uveitis. (2393247)
1990
50
Clinical, pathologic, and immunopathologic characteristics of experimental murine herpes simplex virus stromal keratitis and uveitis is controlled by gene products from the Igh-1 locus on chromosome 12. (3128902)
1987

Genetic Variations for Uveitis

About this section

Expression for genes affiliated with Uveitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for genes affiliated with Uveitis

About this section
Sources:
51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 55SinoBiological
See all sources

Pathways related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0IL10, IL2RA, CXCL10, CXCR3, CCR5, TNF
2
Hide members
10.9IL2RB, CCL2, IFNG, TNFRSF1A, TNF, FAS
3
Hide members
10.9CCR5, FAS, FASLG, CXCR1, CXCR3, TNFRSF1A
4
Hide members
10.9IL10, IL2RA, LTA, CTLA4, FASLG, TNFRSF1A
5
Hide members
10.9CCR2, CCR4, RBP3, CXCL10, CXCR3, CXCR1
6
Hide members
10.9CCR4, IL2RB, IL2RA, CXCL10, CXCR3, LTA
7
Hide members
10.9FAS, TNF, TNFRSF1A, IFNG, IL2RB, IL10
8
Hide members
10.8IL10, CXCL10, FASLG, TNF, TNFRSF1A, IFNG
9
Hide members
10.8CCR5, CCL2, TNFRSF1A, TNF, FAS, LTA
10
Hide members
10.8CCR5, CXCR3, IL2RB, LTA, CCR2, CCR4
11
Hide members
10.8CCR4, CXCL10, CXCR1, CCL2, CCR5, CXCR3
1210.8CXCL10, CXCR1, CCR4, CXCR3, CCR2, CCR5
13
Hide members
10.8CCL2, CXCR1, CXCL10, CCR5, CCR4, CCR2
14
Hide members
10.8FAS, IL10, CTLA4, CCR5, IFNG, TNF
1510.8FASLG, IL2RA, IL10, IL2RB, CCR2, FAS
1610.8CCL2, CXCL10, LTA, FAS, TNF, TNFRSF1A
17
Hide members
10.7CCR5, CCR2, CCL2, CXCR3, CXCL10, CCR4
1810.7IL2RB, IL2RA, IFNG, FASLG, TNF
19
Hide members
10.7IFNG, FASLG, IL2RA, CTLA4, TNF
2010.7FAS, IFNG, FASLG, TNF, IL10
21
Hide members
10.7CCR5, FASLG, IL2RA, IL2RB, IFNG
22
Hide members
10.7TNF, TNFRSF1A, IFNG, IL2RA, IL2RB
23
Hide members
10.7IFNG, TNFRSF1A, TNF, CCR5, LTA
24
Hide members
10.7LTA, TNFRSF1A, IL2RB, IL2RA, TNF
25
Hide members
10.7IFNG, FAS, TNFRSF1A, TNF, FASLG
26
Hide members
10.7LTA, FASLG, TNFRSF1A, FAS, TNF
27
Hide members
10.7TNFRSF1A, FAS, FASLG, TNF, LTA
28
Hide members
10.7TNFRSF1A, TNF, FASLG, LTA, FAS
29
Hide members
10.7IL2RB, CCL2, TNFRSF1A, LTA, IL2RA
3010.7IL10, LTA, TNF, IFNG
31
Hide members
10.7TNF, IFNG, LTA, IL10
32
Immune response Bacterial infections in normal airways
10.7TNF, FAS, IFNG, FASLG
3310.7IFNG, IL10, IL2RB, IL2RA
34
Development PDGF signaling via STATs and NF-kB
Hide members
10.7TNF, CCL2, IL10, IFNG
35
Hide members
10.7IFNG, TNFRSF1A, LTA, TNF
36
Hide members
10.7IL2RB, IL2RA, LTA, FASLG
3710.7TNF, IFNG, CCL2, CCR2
3810.7TNFRSF1A, IL2RB, IFNG, IL2RA
39
Hide members
10.7CXCR3, CXCR1, CCR4, CCR5
40
Apoptosis and survival Caspase cascade
Hide members
10.7FAS, TNF, TNFRSF1A, FASLG
41
Signal transduction JNK pathway
Hide members
10.7FAS, TNF, FASLG, TNFRSF1A
42
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.7TNF, FASLG, FAS, TNFRSF1A
43
Hide members
10.7TNFRSF1A, FASLG, FAS, TNF
4410.7CXCL10, CCR2, CCL2, TNF
4510.6LTA, IFNG, IL10
4610.6LTA, TNF, TNFRSF1A
4710.6TNF, IL10, TNFRSF1A
4810.6IL2RB, IL2RA, TNFRSF1A
49
Hide members
10.5CCR5
5010.5CTLA4

Compounds for genes affiliated with Uveitis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 181)
idCompoundScoreTop Affiliating Genes
1vegf4411.5IL10, CXCL10, CXCR3, CXCR1, CCL2, TNFRSF1A
2nitric oxide44 11 2413.5IFNG, CD69, LTA, FASLG, RBP3, CCL2
3tyrosine4411.5SAG, IL2RB, IL2RA, CXCR3, CXCR1, CXCL10
4il 104411.4IL2RB, IL10, IL2RA, CCR5, CCL2, IFNG
5ionomycin4411.4CD69, IL2RA, IL10, IL2RB, LTA, CTLA4
6infliximab44 49 1113.4IFNG, TNFRSF1A, TNF, FAS, CTLA4, LTA
7tacrolimus44 49 1113.4IFNG, TNF, FASLG, CTLA4, CD69, CXCR3
8retinoic acid44 2412.4CCR4, TNFRSF1A, TNF, FASLG, RBP3, LTA
9rantes4411.4FASLG, IL2RB, IL2RA, CXCR3, CXCR1, LTA
10thymidine44 2412.4CD69, IFNG, TNF, FAS, FASLG, IL2RB
11calcium44 49 11 2414.4CCL2, CXCL10, CCR5, CCR2, IL2RB, CCR4
12ccl344 2812.3CXCR3, CXCL10, IL10, CXCR1, TNF, CCR4
13tarc4411.3CCR4, CCR5, CCL2, IFNG, TNF, CXCR1
14actinomycin d4411.3CCL2, CCR5, IFNG, TNFRSF1A, TNF, FAS
15genistein44 28 59 2 11 2416.3FAS, FASLG, TNF, IFNG, CCL2, CD69
16okt34411.3IL2RA, IL10, IL2RB, LTA, FAS, IFNG
17phosphatidylinositol4411.3FAS, TNFRSF1A, CCL2, FASLG, IL2RB, CD69
18herbimycin a44 5912.3CXCR1, IL2RA, CD69, FAS, CCL2, IFNG
19ifn-alpha4411.3IFNG, FAS, FASLG, CXCR3, CXCL10, IL2RA
20neopterin4411.3CXCL10, TNFRSF1A, IL2RA, LTA, IL2RB, IL10
21cyclosporin a44 28 5913.2IFNG, SAG, CTLA4, LTA, CD69, IL2RA
22histamine44 28 2413.2CCL2, IFNG, CCR5, TNF, CXCR3, CXCL10
23tgf beta14411.2TNF, CCL2, FAS, IL10, TNFRSF1A, FASLG
24simvastatin44 49 59 28 11 2416.2FASLG, TNF, CCR5, IL10, CCL2, IFNG
25groalpha4411.2CXCL10, CXCR1, CXCR3, IL10, CCL2, CCR5
26etanercept44 49 1113.2IFNG, TNFRSF1A, TNF, CXCR3, IL10, LTA
27paraffin4411.2TNFRSF1A, FAS, FASLG, LTA, IL2RA, IL10
28dexamethasone44 49 28 1114.2CTLA4, FASLG, FAS, LTA, CXCR1
29ivig4411.2CCR5, IFNG, SAG, TNFRSF1A, IL2RB
30thalidomide44 49 59 1114.2FASLG, TNF, IL10, IFNG, TNFRSF1A, IL2RA
31methotrexate44 49 1113.1TNFRSF1A, TNF, IL2RB, IL10, IL2RA, FASLG
32cycloheximide4411.1FASLG, RBP3, LTA, CXCL10, IL2RB
33vitamin d4411.1IL2RA, IL10, CCR5, CXCL10, LTA, FAS
34con a4411.1IFNG, IL10, IL2RB, CD69, IL2RA, CTLA4
35endotoxin4411.1TNFRSF1A, FASLG, CXCR3
36lipid4411.0CXCL10, CXCR1, LTA, CTLA4, TNF, IL2RB
37prednisolone44 28 1113.0IL2RA, CCR4, IL2RB, LTA
38rapamycin4411.0CCR5, IFNG, FAS, FASLG, CTLA4, IL2RA
39serine4411.0CTLA4, CXCR3, IL2RB, CCR5, CCL2, TNFRSF1A
40ly2940024411.0FASLG, CTLA4, CCL2, CD69, CXCR3, TNF
41allergens4411.0IFNG, IL10, CXCL10, CXCR3, CD69, CTLA4
422,5-oligoadenylate4411.0IL2RB, IL2RA, CXCL10, TNF
43pge24410.9SAG
44aspartate4410.9CCL2, SAG, FASLG, IL2RB, CCR5
45pentoxifylline44 1111.9IL2RB, LTA
46fmlp4410.8CXCR3, CD69
47morphine44 49 28 1113.8CCR5, SAG, FAS, CXCL10, IL2RB, FASLG
48rs 5043935910.7CCR4, CCR2, CCR5, CXCR1
49sb 22500259 2811.6CCR2, CCR5, CXCR1, CCR4
50sb 2656105910.4CCR4, CCR2, CCR5, CXCR1

GO Terms for genes affiliated with Uveitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989711.1IL2RB, CCR4, CCR5, IFNG, TNF, FAS
2plasma membraneGO:00588611.0CCR2, CCR5, TNFRSF1A, TNF, FAS, CTLA4
3integral to plasma membraneGO:00588710.9TNFRSF1A, CCR5, CCR2, CCR4, TNF, FASLG
4extracellular spaceGO:00561510.8CCL2, IFNG, TNFRSF1A, TNF, FASLG, RBP3
5extracellular regionGO:00557610.5CCL2, IFNG, TNFRSF1A, TNF, FAS, FASLG

Biological processes related to Uveitis according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4IL10, CCR4, CCR2, CCR5, CCL2, TNFRSF1A
2cell surface receptor signaling pathwayGO:00716611.3CCR5, CCL2, IFNG, SAG, CXCR1, CXCR3
3apoptotic processGO:00691511.3IFNG, TNFRSF1A, TNF, FAS, FASLG, LTA
4chemotaxisGO:00693511.2CCR4, CCR2, CCR5, CCL2, CXCR1, CXCR3
5immune responseGO:00695511.2CCR4, CCR2, CCR5, FASLG, CTLA4, CXCL10
6positive regulation of apoptotic processGO:04306511.2TNF, FAS, FASLG, CTLA4, LTA, IL2RA
7chemokine-mediated signaling pathwayGO:07009811.1CCR4, CCR2, CCR5, CCL2, CXCR1
8cell-cell signalingGO:00726711.1CCR5, FASLG, LTA, CXCL10, IL10
9negative regulation of growth of symbiont in hostGO:04413011.1IFNG, TNF, LTA, IL10
10cytokine-mediated signaling pathwayGO:01922111.1CCR2, CCL2, IFNG, TNFRSF1A, IL2RB
11response to drugGO:04249311.1CCL2, IFNG, TNF, LTA, IL10
12extrinsic apoptotic signaling pathway via death domain receptorsGO:00862511.1TNFRSF1A, TNF, FAS, FASLG
13humoral immune responseGO:00695911.1LTA, TNF, IFNG, CCL2
14response to glucocorticoid stimulusGO:05138411.1CCL2, TNF, FAS, IL10
15negative regulation of angiogenesisGO:01652511.1CCR2, CCL2, FASLG, CXCL10
16cellular response to lipopolysaccharideGO:07122211.1CCR5, CCL2, IFNG, IL10
17elevation of cytosolic calcium ion concentrationGO:00720411.1CCR4, CCR2, CCR5, CXCR3
18apoptotic signaling pathwayGO:09719011.0TNFRSF1A, TNF, FAS, FASLG
19dendritic cell chemotaxisGO:00240711.0CXCR1, CCR5, CCR2
20negative regulation of interleukin-6 productionGO:03271511.0IL10, TNF, TNFRSF1A
21response to lipopolysaccharideGO:03249611.0CXCL10, LTA, FASLG, TNFRSF1A
22response to activityGO:01482311.0IL10, TNF, CCL2
23response to hypoxiaGO:00166611.0CCL2, TNFRSF1A, TNF, LTA
24positive regulation of interferon-gamma productionGO:03272911.0CCR2, TNF, LTA
25positive regulation of vitamin D biosynthetic processGO:06055710.9IFNG, TNF
26positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.9CCR2, CCL2
27positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9TNF, LTA
28inflammatory cell apoptotic processGO:00692510.9FAS, FASLG
29calcium-mediated signalingGO:01972210.9CXCR3, TNF, CCR5
30receptor biosynthetic processGO:03280010.9IL10, TNF
31activation of necroptosis by extracellular signalsGO:06055510.9FASLG, TNF
32positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9TNF, IFNG
33regulation of vascular endothelial growth factor productionGO:01057410.9CCL2, CCR2
34necrotic cell deathGO:07026510.9TNF, FASLG
35negative regulation of cytokine secretion involved in immune responseGO:00274010.9TNF, IL10
36positive regulation of necrotic cell deathGO:01094010.8TNF, FAS
37MAPK cascadeGO:00016510.8TNF, CCL2, CCR5
38activation-induced cell death of T cellsGO:00692410.8FAS, IL2RA
39positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA
40positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
41transformed cell apoptotic processGO:00692710.8TNF, FAS
42positive regulation of chemokine biosynthetic processGO:04508010.7TNF, IFNG
43activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7FASLG, FAS, TNF
44positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.7IFNG, TNFRSF1A
45signal transductionGO:00716510.7CCL2, FAS, FASLG, LTA, CXCL10, IL2RB
46regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.6FAS, FASLG
47positive regulation of synaptic transmissionGO:05080610.6TNF, CCL2
48cellular homeostasisGO:01972510.3CCL2, CCR2

Molecular functions related to Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.9CXCR3, CXCR1, CCR5, CCR2, CCR4
2cytokine activityGO:00512510.9IFNG, TNF, FASLG, LTA, IL10
3C-C chemokine receptor activityGO:01649310.7CCR5, CCR2, CCR4
4tumor necrosis factor receptor bindingGO:00516410.7TNF, FASLG, LTA
5receptor bindingGO:00510210.7CXCL10, LTA, FASLG, CCL2
6CCR2 chemokine receptor bindingGO:03172710.6CCR2, CCL2
7interleukin-2 bindingGO:01997610.5IL2RA, IL2RB
8interleukin-2 receptor activityGO:00491110.3IL2RA, IL2RB

Products for genes affiliated with Uveitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uveitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet