MCID: UVT001
MIFTS: 66

Uveitis malady

Summaries for Uveitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Uveitis, also known as uveitis, nos, is related to posterior uveitis and nephritis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Influenza A. The drugs atropine and methylatropine nitrate and the compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uveitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

uveitis 8 10 45 61
uveitis, nos 8
uveitis nos 8


External Ids:

Disease Ontology8 DOID:13141
MeSH35 D014605
NCIt40 C26909

Related Diseases for Uveitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Uveitis family:

infectious anterior uveitis posterior uveitis
intermediate uveitis anterior uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 471)
idRelated DiseaseScoreTop Affiliating Genes
1posterior uveitis31.4IL2RB, IL2RA, SAG
2nephritis31.2CXCR3, LTA, CCL2
3arthritis31.1IL2RB, IL10, CXCL10, CXCR3, CXCR1, CD69
4ankylosing spondylitis30.8TNF
5vasculitis30.7RBP3, CTLA4, TNF, SAG, CCL2
6retinal vasculitis30.6SAG
7juvenile rheumatoid arthritis30.6IL2RB, IL2RA, LTA, TNF
8tuberculosis30.4IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
9behcet's disease30.3IL2RA, LTA, RBP3, CTLA4, TNF, SAG
10vogt-koyanagi-harada disease30.2IL2RA, FASLG, FAS
11ulcerative colitis30.1IL10, IL2RA, CXCL10, CXCR3, CXCR1, LTA
12acquired immunodeficiency syndrome30.1CCR5, CCR2
13acute leukemia30.1CXCR1
14crohn's disease30.0TNF
15systemic lupus erythematosus29.9IL2RB, IL10, IL2RA, CXCL10, CXCR3, CD69
16graft versus host disease29.9IL2RB, IL10, IL2RA, LTA, CTLA4, FASLG
17t-cell leukemia29.9IL2RB, IL2RA, LTA, FASLG, FAS, TNFRSF1A
18psoriatic arthritis29.9TNF
19asthma29.6IL10, IL2RA, CXCL10, CXCR3, CXCR1, CD69
20graves' disease29.6IL2RA, CXCL10, CXCR3, CD69, LTA, CTLA4
21hepatitis c29.6IL10, CXCL10, CXCR3, CD69, CTLA4, FAS
22pulmonary sarcoidosis29.6IL2RB, IL2RA, CXCR3, LTA, TNF, IFNG
23mycosis fungoides29.6IL2RB, IL2RA, CXCL10, CXCR3, CXCR1, CCR4
24hepatitis b29.6IL10, IL2RA, CXCL10, CTLA4, IFNG, CCR5
25arthropathy29.6CXCL10, CD69, CTLA4, TNF
26vascular disease29.6IL10, FASLG, TNF, TNFRSF1A
27autoimmune lymphoproliferative syndrome29.6IL10, IL2RA, FASLG, FAS
28astrocytoma29.6CXCL10, LTA, FASLG
29thyroiditis29.6CTLA4, FASLG
30wegener's granulomatosis29.6CTLA4, CCR5
31proliferative diabetic retinopathy29.6CXCL10, CCL2
32alopecia areata29.6IFNG
33kawasaki disease29.6CCL2
34polymyalgia rheumatica29.6IL2RB
35adenoma29.6CTLA4, SAG
36primary biliary cirrhosis29.6IL2RB, LTA, CTLA4
37anterior uveitis11.1
38n syndrome10.8
39spondylitis10.5
40tuberculous uveitis10.5
41cystoid macular edema10.5
42idiopathic anterior uveitis10.5
43cytomegalovirus retinitis10.4
44pars planitis10.3
45blau syndrome10.3
46fuchs' heterochromic uveitis10.3
47spondyloarthropathy10.3
48choroiditis10.2
49syphilis10.2
50tubulointerstitial nephritis and uveitis10.2

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to uveitis

Clinical Features for Uveitis

Drugs & Therapeutics for Uveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Uveitis

Drug clinical trials:

Search ClinicalTrials for Uveitis

Search NIH Clinical Center for Uveitis

Search CenterWatch for Uveitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Uveitis

Anatomical Context for Uveitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Uveitis:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Retina, Thyroid, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Pineal

Animal Models for Uveitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Uveitis:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.6CCL2, CCR5, CCR2, CCR4, IFNG, TNF
2MP:000539711.5TNFRSF1A, IL2RA, IL2RB, CCR4, CCR2, CCR5
3MP:000538411.5CD69, LTA, CTLA4, FASLG, FAS, TNF
4MP:001076811.3CTLA4, CCR5, TNFRSF1A, IFNG, TNF, FAS
5MP:000537011.3TNF, FAS, FASLG, CTLA4, IL10, IL2RB
6MP:000538511.3IFNG, TNFRSF1A, TNF, FAS, FASLG, CTLA4
7MP:000538111.2CCL2, FAS, CCR5, IL10, IL2RA, CTLA4
8MP:000537611.2CXCL10, TNF, CCR2, CCR5, CCL2, IFNG
9MP:000200611.1IL10, CXCR3, FASLG, CCR5, TNFRSF1A, IFNG
10MP:000538811.0LTA, CXCR3, FASLG, FAS, CTLA4
11MP:000363110.9CCR2, CCR5, SAG, FAS, TNFRSF1A, LTA
12MP:000537810.9IL2RB, IL10, IL2RA, LTA, FAS, TNF
13MP:000539110.9RBP3, CCR2, SAG
14MP:000537910.9FASLG, IL2RB, IFNG, TNF, FAS, LTA
15MP:000539010.9TNFRSF1A, LTA, FASLG, FAS
16MP:000538610.6CCR5, CCL2, IFNG, TNFRSF1A, CCR2, LTA
17MP:001077110.6FASLG, CTLA4, FAS
18MP:000538910.6CCR5, TNFRSF1A, FASLG, IL2RB, FAS

Publications for Uveitis

Sources:
51PubMed
See all sources

Articles related to Uveitis:

(show top 50)    (show all 1820)
idTitleAuthorsYear
1
The future of uveitis treatment. (24169255)
2014
2
Development of Macular Edema and Impact on Visual Acuity in Uveitis Associated with Juvenile Idiopathic Arthritis. (24410459)
2014
3
Intraocular methotrexate can induce extended remission in some patients in noninfectious uveitis. (23615343)
2013
4
The standardization of uveitis nomenclature project: the future is here. (23764704)
2013
5
Leflunomide, a valid and safe drug for the treatment of chronic anterior uveitis associated with juvenile idiopathic arthritis. (23828309)
2013
6
Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis. (24260551)
2013
7
Bilateral severe anterior uveitis after unilateral selective laser trabeculoplasty. (22957742)
2013
8
Immune recovery uveitis masked as an endogenous endophthalmitis in a patient with active CMV retinitis. (23691386)
2013
9
The uveitis and its relationship with disease activity and quality of life in Moroccan children with juvenile idiopathic arthritis. (23636793)
2013
10
Review for disease of the year: epidemiology of juvenile idiopathic arthritis and its associated uveitis: the probable risk factors. (23713827)
2013
11
Cytomegalovirus anterior uveitis in immunocompetent individuals following topical prostaglandin analogues. (23837444)
2013
12
Golimumab for the treatment of refractory juvenile idiopathic arthritis-associated uveitis. (22581347)
2012
13
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. (22562515)
2012
14
The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. (22752308)
2012
15
Association of C2 and CFB polymorphisms with anterior uveitis. (22714898)
2012
16
Chronic anterior uveitis in common variable immunodeficiency. (22106916)
2011
17
Management of bilateral uveitis secondary to intraocular filariasis. (21987687)
2011
18
Human herpesvirus 6-associated uveitis with optic neuritis diagnosed by multiplex PCR. (21814813)
2011
19
Cytomegalovirus anterior uveitis: outcome of treatment. (20576767)
2010
20
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
21
Treatment of noninfectious posterior uveitis with dexamethasone intravitreal implant. (21188153)
2010
22
Effects of infliximab in the treatment of refractory posterior uveitis of BehAset's disease after withdrawal of infusions. (20490893)
2010
23
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
24
Bilateral anterior uveitis associated with clomiphene citrate. (18379937)
2008
25
Analysis of Crohn's disease-related CARD15 polymorphisms in Spanish patients with idiopathic uveitis. (18219096)
2008
26
Diminished frequency and function of CD4+CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome. (18421089)
2008
27
Hypopyon in leprosy uveitis. (17244972)
2007
28
Risks of relapse in patients with acute anterior uveitis. (17035277)
2007
29
Pseudouveitis--analysis of cases misdiagnosed as posterior uveitis. (16507486)
2006
30
Polymorphisms within the tumor necrosis factor-alpha promoter region in patients with HLA-B27-associated uveitis: association with susceptibility and clinical manifestations. (16581430)
2006
31
Cytokine gene polymorphisms involved in chronicity and complications of anterior uveitis. (17005410)
2006
32
Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. (16280979)
2005
33
Tubulo-interstitial nephritis and uveitis with bilateral optic disc oedema. (15131689)
2004
34
Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis. (15153539)
2004
35
Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules. (12506079)
2003
36
Human S-antigen determinant recognition in uveitis. (11726628)
2001
37
Retinitis pigmentosa, Coats disease and uveitis. (10544975)
1999
38
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
39
In vitro effects of immunosuppressive agents on cytokine production by HTLV-I-infected T cell clones derived from the ocular fluid of patients with HTLV-I uveitis. (8805102)
1996
40
HLA-DR8 and acute anterior uveitis in ankylosing spondylitis. (7718009)
1995
41
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
42
Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study. (8462650)
1993
43
Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis. (8481650)
1993
44
Interleukin 2 receptor membrane bound and in soluble form in the aqueous humor and peripheral blood of patients with acute untreated uveitis. (1433001)
1992
45
Results of extracapsular cataract extraction with intraocular lens implantation in eyes with uveitis and Fuchs' heterochromic iridocyclitis. (1490138)
1992
46
Systemic sulfonamides as a cause of bilateral, anterior uveitis. (1987952)
1991
47
Self diagnosis in recurrent acute anterior uveitis. (2060664)
1991
48
Anterior uveitis and hypopyon. (1808812)
1991
49
Spontaneous lens subluxation in uveitis. (2248347)
1990
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Genetic Variations for Uveitis

Expression for genes affiliated with Uveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for genes affiliated with Uveitis

Sources:
52QIAGEN, 30KEGG, 54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 56SinoBiological
See all sources

Pathways related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0IL10, IL2RA, CXCL10, CXCR3, CCR5, TNF
2
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10.9IL2RB, CCL2, IFNG, TNFRSF1A, TNF, FAS
3
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10.9CCR5, FAS, FASLG, CXCR1, CXCR3, TNFRSF1A
4
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10.9IL10, IL2RA, LTA, CTLA4, FASLG, TNFRSF1A
5
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10.9CCR2, CCR4, RBP3, CXCL10, CXCR3, CXCR1
6
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10.9CCR4, IL2RB, IL2RA, CXCL10, CXCR3, LTA
7
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10.9FAS, TNF, TNFRSF1A, IFNG, IL2RB, IL10
8
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10.8IL10, CXCL10, FASLG, TNF, TNFRSF1A, IFNG
9
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10.8CCR5, CCL2, TNFRSF1A, TNF, FAS, LTA
10
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10.8CCR5, CXCR3, IL2RB, LTA, CCR2, CCR4
11
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10.8CCR4, CXCL10, CXCR1, CCL2, CCR5, CXCR3
1210.8CXCL10, CXCR1, CCR4, CXCR3, CCR2, CCR5
13
Hide members
10.8CCL2, CXCR1, CXCL10, CCR5, CCR4, CCR2
14
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10.8FAS, IL10, CTLA4, CCR5, IFNG, TNF
1510.8FASLG, IL2RA, IL10, IL2RB, CCR2, FAS
1610.8CCL2, CXCL10, LTA, FAS, TNF, TNFRSF1A
17
Hide members
10.7CCR5, CCR2, CCL2, CXCR3, CXCL10, CCR4
1810.7IL2RB, IL2RA, IFNG, FASLG, TNF
19
Hide members
10.7IFNG, FASLG, IL2RA, CTLA4, TNF
2010.7FAS, IFNG, FASLG, TNF, IL10
21
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10.7CCR5, FASLG, IL2RA, IL2RB, IFNG
22
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10.7TNF, TNFRSF1A, IFNG, IL2RA, IL2RB
23
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10.7IFNG, TNFRSF1A, TNF, CCR5, LTA
24
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10.7LTA, TNFRSF1A, IL2RB, IL2RA, TNF
25
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10.7IFNG, FAS, TNFRSF1A, TNF, FASLG
26
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10.7LTA, FASLG, TNFRSF1A, FAS, TNF
27
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10.7TNFRSF1A, FAS, FASLG, TNF, LTA
28
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10.7TNFRSF1A, TNF, FASLG, LTA, FAS
29
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10.7IL2RB, CCL2, TNFRSF1A, LTA, IL2RA
3010.7IL10, LTA, TNF, IFNG
31
Hide members
10.7TNF, IFNG, LTA, IL10
32
Immune response Bacterial infections in normal airways
10.7TNF, FAS, IFNG, FASLG
3310.7IFNG, IL10, IL2RB, IL2RA
34
Development PDGF signaling via STATs and NF-kB
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10.7TNF, CCL2, IL10, IFNG
35
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10.7IFNG, TNFRSF1A, LTA, TNF
36
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10.7IL2RB, IL2RA, LTA, FASLG
3710.7TNF, IFNG, CCL2, CCR2
3810.7TNFRSF1A, IL2RB, IFNG, IL2RA
39
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10.7CXCR3, CXCR1, CCR4, CCR5
40
Apoptosis and survival Caspase cascade
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10.7FAS, TNF, TNFRSF1A, FASLG
41
Signal transduction JNK pathway
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10.7FAS, TNF, FASLG, TNFRSF1A
42
Apoptosis and survival Apoptotic TNF-family pathways
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10.7TNF, FASLG, FAS, TNFRSF1A
43
Hide members
10.7TNFRSF1A, FASLG, FAS, TNF
4410.7CXCL10, CCR2, CCL2, TNF
4510.6LTA, IFNG, IL10
4610.6LTA, TNF, TNFRSF1A
4710.6TNF, IL10, TNFRSF1A
4810.6IL2RB, IL2RA, TNFRSF1A
49
Hide members
10.5CCR5
5010.5CTLA4

Compounds for genes affiliated with Uveitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 181)
idCompoundScoreTop Affiliating Genes
1vegf4511.5IL10, CXCL10, CXCR3, CXCR1, CCL2, TNFRSF1A
2nitric oxide45 11 2413.5IFNG, CD69, LTA, FASLG, RBP3, CCL2
3tyrosine4511.5SAG, IL2RB, IL2RA, CXCR3, CXCR1, CXCL10
4il 104511.4IL2RB, IL10, IL2RA, CCR5, CCL2, IFNG
5ionomycin4511.4CD69, IL2RA, IL10, IL2RB, LTA, CTLA4
6infliximab45 50 1113.4IFNG, TNFRSF1A, TNF, FAS, CTLA4, LTA
7tacrolimus45 50 1113.4IFNG, TNF, FASLG, CTLA4, CD69, CXCR3
8retinoic acid45 2412.4CCR4, TNFRSF1A, TNF, FASLG, RBP3, LTA
9rantes4511.4FASLG, IL2RB, IL2RA, CXCR3, CXCR1, LTA
10thymidine45 2412.4CD69, IFNG, TNF, FAS, FASLG, IL2RB
11calcium45 50 11 2414.4CCL2, CXCL10, CCR5, CCR2, IL2RB, CCR4
12ccl345 2912.3CXCR3, CXCL10, IL10, CXCR1, TNF, CCR4
13tarc4511.3CCR4, CCR5, CCL2, IFNG, TNF, CXCR1
14actinomycin d4511.3CCL2, CCR5, IFNG, TNFRSF1A, TNF, FAS
15genistein45 29 60 2 11 2416.3FAS, FASLG, TNF, IFNG, CCL2, CD69
16okt34511.3IL2RA, IL10, IL2RB, LTA, FAS, IFNG
17phosphatidylinositol4511.3FAS, TNFRSF1A, CCL2, FASLG, IL2RB, CD69
18herbimycin a45 6012.3CXCR1, IL2RA, CD69, FAS, CCL2, IFNG
19ifn-alpha4511.3IFNG, FAS, FASLG, CXCR3, CXCL10, IL2RA
20neopterin4511.3CXCL10, TNFRSF1A, IL2RA, LTA, IL2RB, IL10
21cyclosporin a45 29 6013.2IFNG, SAG, CTLA4, LTA, CD69, IL2RA
22histamine45 29 2413.2CCL2, IFNG, CCR5, TNF, CXCR3, CXCL10
23tgf beta14511.2TNF, CCL2, FAS, IL10, TNFRSF1A, FASLG
24simvastatin45 50 60 29 11 2416.2FASLG, TNF, CCR5, IL10, CCL2, IFNG
25groalpha4511.2CXCL10, CXCR1, CXCR3, IL10, CCL2, CCR5
26etanercept45 50 1113.2IFNG, TNFRSF1A, TNF, CXCR3, IL10, LTA
27paraffin4511.2TNFRSF1A, FAS, FASLG, LTA, IL2RA, IL10
28dexamethasone45 50 29 1114.2CTLA4, FASLG, FAS, LTA, CXCR1
29ivig4511.2CCR5, IFNG, SAG, TNFRSF1A, IL2RB
30thalidomide45 50 60 1114.2FASLG, TNF, IL10, IFNG, TNFRSF1A, IL2RA
31methotrexate45 50 1113.1TNFRSF1A, TNF, IL2RB, IL10, IL2RA, FASLG
32cycloheximide4511.1FASLG, RBP3, LTA, CXCL10, IL2RB
33vitamin d4511.1IL2RA, IL10, CCR5, CXCL10, LTA, FAS
34con a4511.1IFNG, IL10, IL2RB, CD69, IL2RA, CTLA4
35endotoxin4511.1TNFRSF1A, FASLG, CXCR3
36lipid4511.0CXCL10, CXCR1, LTA, CTLA4, TNF, IL2RB
37prednisolone45 29 1113.0IL2RA, CCR4, IL2RB, LTA
38rapamycin4511.0CCR5, IFNG, FAS, FASLG, CTLA4, IL2RA
39serine4511.0CTLA4, CXCR3, IL2RB, CCR5, CCL2, TNFRSF1A
40ly2940024511.0FASLG, CTLA4, CCL2, CD69, CXCR3, TNF
41allergens4511.0IFNG, IL10, CXCL10, CXCR3, CD69, CTLA4
422,5-oligoadenylate4511.0IL2RB, IL2RA, CXCL10, TNF
43pge24510.9SAG
44aspartate4510.9CCL2, SAG, FASLG, IL2RB, CCR5
45pentoxifylline45 1111.9IL2RB, LTA
46fmlp4510.8CXCR3, CD69
47morphine45 50 29 1113.8CCR5, SAG, FAS, CXCL10, IL2RB, FASLG
48rs 5043936010.7CCR4, CCR2, CCR5, CXCR1
49sb 22500260 2911.6CCR2, CCR5, CXCR1, CCR4
50sb 2656106010.4CCR4, CCR2, CCR5, CXCR1

GO Terms for genes affiliated with Uveitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989711.1IL2RB, CD69, CCR4, CXCR3, CXCL10, FASLG
2plasma membraneGO:00588611.0CCR5, IL2RB, IL2RA, CXCR1, CTLA4, FAS
3integral to plasma membraneGO:00588710.9CTLA4, CCR2, CCR5, TNFRSF1A, TNF, FASLG
4extracellular spaceGO:00561510.8CCL2, IFNG, TNFRSF1A, TNF, RBP3, LTA
5extracellular regionGO:00557610.5RBP3, CXCL10, CCL2, TNFRSF1A, TNF, IFNG

Biological processes related to Uveitis according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4CXCR3, CCR2, CCR5, CCL2, TNFRSF1A, TNF
2cell surface receptor signaling pathwayGO:00716611.3CXCL10, CCL2, IFNG, SAG, CXCR1, CXCR3
3apoptotic processGO:00691511.3TNF, IL2RA, CXCR3, LTA, IFNG, TNFRSF1A
4chemotaxisGO:00693511.2CCR2, CCR5, CCL2, CXCR1, CCR4, CXCR3
5immune responseGO:00695511.2CCR2, IL2RA, CXCL10, CTLA4, FASLG, CCR5
6positive regulation of apoptotic processGO:04306511.2CTLA4, IL2RA, FAS, LTA, TNF, FASLG
7chemokine-mediated signaling pathwayGO:07009811.1CCR5, CCL2, CCR2, CCR4, CXCR1
8cell-cell signalingGO:00726711.1CCR5, FASLG, LTA, CXCL10, IL10
9negative regulation of growth of symbiont in hostGO:04413011.1IL10, LTA, TNF, IFNG
10cytokine-mediated signaling pathwayGO:01922111.1TNFRSF1A, IL2RB, IFNG, CCL2, CCR2
11response to drugGO:04249311.1IL10, LTA, TNF, IFNG, CCL2
12extrinsic apoptotic signaling pathway via death domain receptorsGO:00862511.1TNFRSF1A, FASLG, TNF, FAS
13humoral immune responseGO:00695911.1IFNG, TNF, LTA, CCL2
14response to glucocorticoid stimulusGO:05138411.1IL10, CCL2, TNF, FAS
15negative regulation of angiogenesisGO:01652511.1CCL2, CCR2, FASLG, CXCL10
16cellular response to lipopolysaccharideGO:07122211.1CCR5, CCL2, IFNG, IL10
17elevation of cytosolic calcium ion concentrationGO:00720411.1CXCR3, CCR5, CCR2, CCR4
18apoptotic signaling pathwayGO:09719011.0FAS, TNF, TNFRSF1A, FASLG
19dendritic cell chemotaxisGO:00240711.0CCR5, CCR2, CXCR1
20negative regulation of interleukin-6 productionGO:03271511.0IL10, TNF, TNFRSF1A
21response to lipopolysaccharideGO:03249611.0LTA, TNFRSF1A, CXCL10, FASLG
22response to activityGO:01482311.0CCL2, TNF, IL10
23response to hypoxiaGO:00166611.0CCL2, TNF, TNFRSF1A, LTA
24positive regulation of interferon-gamma productionGO:03272911.0LTA, CCR2, TNF
25positive regulation of vitamin D biosynthetic processGO:06055710.9TNF, IFNG
26positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.9CCR2, CCL2
27positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9TNF, LTA
28inflammatory cell apoptotic processGO:00692510.9FAS, FASLG
29calcium-mediated signalingGO:01972210.9CCR5, TNF, CXCR3
30receptor biosynthetic processGO:03280010.9IL10, TNF
31activation of necroptosis by extracellular signalsGO:06055510.9FASLG, TNF
32positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9IFNG, TNF
33negative regulation of cytokine secretion involved in immune responseGO:00274010.9IL10, TNF
34regulation of vascular endothelial growth factor productionGO:01057410.9CCR2, CCL2
35necrotic cell deathGO:07026510.9FASLG, TNF
36positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA
37MAPK cascadeGO:00016510.8CCL2, CCR5, TNF
38activation-induced cell death of T cellsGO:00692410.8IL2RA, FAS
39positive regulation of necrotic cell deathGO:01094010.8FAS, TNF
40transformed cell apoptotic processGO:00692710.8FAS, TNF
41positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL10
42positive regulation of chemokine biosynthetic processGO:04508010.7TNF, IFNG
43activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.7TNF, FAS, FASLG
44positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.7TNFRSF1A, IFNG
45signal transductionGO:00716510.7CCL2, CXCL10, IL2RB, FAS, LTA, FASLG
46regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.6FASLG, FAS
47positive regulation of synaptic transmissionGO:05080610.6TNF, CCL2
48cellular homeostasisGO:01972510.3CCR2, CCL2

Molecular functions related to Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.9CXCR3, CXCR1, CCR5, CCR2, CCR4
2cytokine activityGO:00512510.9IFNG, TNF, FASLG, LTA, IL10
3C-C chemokine receptor activityGO:01649310.7CCR5, CCR2, CCR4
4tumor necrosis factor receptor bindingGO:00516410.7TNF, FASLG, LTA
5receptor bindingGO:00510210.7CXCL10, LTA, FASLG, CCL2
6CCR2 chemokine receptor bindingGO:03172710.6CCR2, CCL2
7interleukin-2 bindingGO:01997610.5IL2RA, IL2RB
8interleukin-2 receptor activityGO:00491110.3IL2RA, IL2RB

Products for genes affiliated with Uveitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet