MCID: UVT001
MIFTS: 57

Uveitis malady

Rare diseases category

Summaries for Uveitis

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Wikipedia:63 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards based summary: Uveitis is related to posterior uveitis and intermediate uveitis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Cellular Transformation by HTLV1 and Inflammatory Response Pathway. The drugs atropine and methylatropine nitrate and the compounds natalizumab and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are no phenotypic analysis and integument.

Aliases & Classifications for Uveitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH
See all sources

Uveitis, Aliases & Descriptions:

Name: Uveitis 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:13141
ICD9CM27 364
NCIt38 C26909
MeSH33 D014605

Related Diseases for Uveitis

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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Intermediate Uveitis Anterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 419)
idRelated DiseaseScoreTop Affiliating Genes
1posterior uveitis31.8IL2RB, IL2RA, SAG
2intermediate uveitis31.6CCR5, CXCR3, IL2RA
3retinal vasculitis31.4SAG
4blau syndrome31.3TNF
5endophthalmitis31.3SAG
6juvenile rheumatoid arthritis30.8LTA, IL2RA, TNF, IL2RB
7vasculitis30.8TNF, SAG, RBP3
8chorioretinitis30.7SAG, RBP3
9pneumonia30.7TNF, IL2RB, IL10
10thyroiditis30.7FASLG
11colitis30.5IFNG, TNF, IL10
12arthritis30.4IL10, CXCR1, CCR5, CXCR3, TNF, IFNG
13vogt-koyanagi-harada disease30.4FASLG, IL2RA, FAS
14hepatitis30.2IL2RB, LTA, FASLG
15common variable immunodeficiency30.2IL2RB, IL10, IL2RA
16psoriatic arthritis30.2TNF
17tuberculosis30.2TNF, IL10, IL2RA, IFNG, CXCR1, CXCR3
18inflammatory bowel disease30.1IL10, TNF, IFNG, LTA, CCR5
19eosinophilia30.1IL10, IL2RB, IFNG, IL2RA
20myasthenia gravis30.0LTA, CCR5, IFNG, IL10
21hodgkin lymphoma30.0IL2RA, LTA, IL2RB
22behcet's disease29.9LTA, TNF, RBP3, IL2RA, CCR5, SAG
23mycosis fungoides29.9CXCR3, IL2RA, IL2RB, CXCR1
24hypersensitivity syndrome, carbamazepine-induced29.8FASLG, FAS
25psoriasis29.8IL10, LTA, IL2RA, IFNG, CXCR1, CXCR3
26chronic lymphocytic leukemia29.8CCR5, LTA, CXCR3, IL2RA
27ulcerative colitis29.8CXCR3, TNF, LTA, IL10, IFNG, IL2RA
28hepatitis c29.6FAS, IL10, IFNG, CCR5, CXCR3
29t-cell leukemia29.6LTA, FAS, FASLG, IL2RA, IL2RB
30autoimmune lymphoproliferative syndrome29.6FASLG, FAS, IL2RA, IL10
31influenza29.5CXCR3, CCR5, IFNG, IL2RB, LTA
32leukemia29.2FAS, TNF, IL2RB, IL2RA, CXCR3, CXCR1
33graves' disease29.1LTA, IL2RA, IFNG, CCR5, CXCR3, FASLG
34prostate cancer29.1FASLG, FAS, LTA, CCR5, CXCR1
35rheumatoid arthritis29.0TNF, LTA, IL10, IL2RB, IL2RA, IFNG
36melanoma28.6IFNG, IL2RB, CCR5, TNF, CXCR1, IL10
37systemic lupus erythematosus28.5TNF, FAS, FASLG, CXCR3, CCR5, IFNG
38anterior uveitis11.2
39nephritis10.8
40retinitis10.8
41tubulointerstitial nephritis and uveitis10.8
42hypopyon10.6
43spondylitis10.6
44tuberculous uveitis10.6
45cataract10.5
46farmer's lung10.5IL2RA
47pleurisy10.5IL2RA
48interstitial nephritis10.5
49scleritis10.5
50choroiditis10.4

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to uveitis

Symptoms for Uveitis

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Drugs & Therapeutics for Uveitis

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Drug clinical trials:

Search ClinicalTrials for Uveitis

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Uveitis

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Anatomical Context for Uveitis

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MalaCards organs/tissues related to Uveitis:

31
Eye, T cells, Testes, Endothelial, Retina, Skin, Bone marrow, Bone, Myeloid, Monocytes, Neutrophil, Lung, Thyroid, Brain, Kidney, Breast, Prostate, B cells, Pineal, Lymph node, Spleen, Spinal cord, Liver, Nk cells, Tongue

Animal Models for Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Uveitis:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6IL10, IFNG, CCR5, CCR2, TNF
2MP:00107717.9TNF, FAS, FASLG, IFNG, IL2RB, IL10
3MP:00053677.9FAS, FASLG, CXCR3, CCR2, IFNG
4MP:00053797.9TNF, FAS, FASLG, IFNG, IL2RB, IL10
5MP:00053907.7TNF, FAS, FASLG, CCR2, IFNG, IL10
6MP:00053897.7TNF, FAS, FASLG, CCR5, IFNG, IL2RB
7MP:00053887.5TNF, FAS, FASLG, CXCR3, CCR2, IFNG
8MP:00053817.4TNF, FAS, FASLG, CCR2, CCR5, IFNG
9MP:00053787.4TNF, FAS, CCR2, IFNG, IL2RA, IL2RB
10MP:00020067.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
11MP:00053867.4TNF, FAS, CCR2, CCR5, IFNG, IL2RB
12MP:00053847.2TNF, FAS, FASLG, CXCR3, CCR2, CCR5
13MP:00053707.0TNF, FAS, FASLG, CCR2, CCR5, IFNG
14MP:00053857.0TNF, FAS, FASLG, CXCR3, CCR2, CCR5
15MP:00053766.9TNF, FAS, FASLG, CXCR3, CCR2, CCR5
16MP:00053976.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
17MP:00053876.4CXCR3, FASLG, FAS, TNF, CCR2, CCR5
18MP:00107686.4TNF, FAS, FASLG, CXCR3, CCR2, CCR5
19MP:00053916.3LTA, TNF, FAS, FASLG, SAG, CCR2
20MP:00036316.2SAG, FASLG, FAS, TNF, CCR2, CCR5

Publications for Uveitis

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Articles related to Uveitis:

(show top 50)    (show all 1908)
idTitleAuthorsYear
1
Prognosis and impact of Equine Recurrent Uveitis. (25891653)
2015
2
Urinary I^2-Microglobulin Testing in Pediatric Uveitis: A Case Report of a 9-Year-Old Boy with Renal and Ocular Sarcoidosis. (25873895)
2015
3
Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus. (25124341)
2014
4
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
5
Anterior chamber intraocular lens implantation in patients with a history of chronic uveitis: Five-year follow-up. (24238942)
2014
6
Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis. (25147441)
2014
7
Anterior segment optical coherence tomography in acute anterior uveitis. (25076363)
2014
8
Toxic granulomatous anterior uveitis in live intracameral cysticercosis masquerading as leukocoria. (25433748)
2014
9
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
10
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
11
Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. (23062650)
2013
12
Response of pediatric uveitis to tumor necrosis factor-I+ inhibitors. (23818712)
2013
13
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. (23676143)
2013
14
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. (24131357)
2013
15
Infectious causes of posterior uveitis and panuveitis in Thailand. (22539102)
2012
16
Follow-up of erlotinib related uveitis. (22892235)
2012
17
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
18
The role of biologic agents in the management of non-infectious uveitis. (22780091)
2012
19
Brimonidine (Alphagan) associated anterior uveitis. (22257785)
2012
20
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
21
Mucoepidermoid carcinoma as a masquerade syndrome of scleral melting and granulomatous kerato-uveitis. (21484645)
2011
22
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. (21836350)
2011
23
Uveitis in Blau syndrome from a de novo mutation of the NOD2/CARD15 gene. (21596301)
2011
24
CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome. (21976957)
2011
25
Intravitreal infliximab in experimental endotoxin-induced uveitis. (19787603)
2009
26
Recent advances in studies of clinical treatment of uveitis]. (19176129)
2008
27
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
28
Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor. (18469182)
2008
29
Retrospective analysis of children with uveitis treated with infliximab. (18930672)
2008
30
Bilateral acute anterior uveitis as a side effect of trimethoprim. (16751748)
2007
31
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
32
Intermediate uveitis. (16282148)
2005
33
Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. (16280979)
2005
34
Recurrent uveitis in a patient with juvenile spondyloarthropathy associated with tumour necrosis factor alpha inhibitors. (12480683)
2003
35
Acute anterior uveitis. (15366165)
2003
36
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
37
Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN-gamma production and the function of dendritic cells. (12869029)
2003
38
Diagnosis and management of herpetic anterior uveitis. (12189614)
2002
39
Hypopyon uveitis. (11525785)
2001
40
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
41
Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma. (19078330)
1998
42
Whipple's syndrome (uveitis, B27-negative spondylarthropathy, meningitis, and lymphadenopathy) associated with Arthrobacter sp. infection. (9787360)
1998
43
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
44
Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen--first results. (9232451)
1997
45
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
46
Laboratory investigations in posterior uveitis. (8964666)
1995
47
Humoral and cellular immune responses to retinal S-antigen in uveitis patients]. (8223034)
1993
48
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
49
Experimental autoimmune posterior uveitis accompanied by epitheloid cell accumulations (EAPU). A new type of experimental ocular disease induced by immunization with PEP-65, a pigment epithelial polypeptide preparation. (1486940)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Uveitis

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Expression for genes affiliated with Uveitis

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Search GEO for disease gene expression data for Uveitis.

Pathways for genes affiliated with Uveitis

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Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TNF, IFNG, LTA
29.6IFNG, IL2RA, IL2RB
3
Show member pathways
IL-2 Signaling pathway36
9.6IFNG, IL2RA, IL2RB
49.5IL10, IFNG, TNF
59.5TNF, IFNG, IL10
69.5TNF, IFNG, IL10
79.4LTA, IL10, IFNG
89.4IFNG, FASLG, TNF
99.4IFNG, CCR2, TNF
109.4IFNG, CCR2, TNF
119.4CXCR3, CXCR1, CCR5
12
Show member pathways
9.3IL2RB, IL2RA, IFNG, TNF
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.3LTA, IL2RB, IL2RA, TNF
149.3LTA, IL2RB, IL2RA, TNF
159.3TNF, FAS, LTA
169.2TNF, IFNG, IL10, LTA
17
Show member pathways
IL27-mediated signaling events36
9.2TNF, IFNG, IL10, LTA
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.2TNF, FASLG, IFNG, IL2RA
19
Show member pathways
Type III interferon signaling36
9.2IFNG, IL2RA, IL2RB, IL10
20
Show member pathways
9.1LTA, IFNG, CCR5, TNF
219.1IL2RB, IL2RA, CCR5, CXCR1
229.1TNF, FAS, FASLG
23
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.1TNF, FAS, FASLG
24
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.1FASLG, FAS, TNF
25
Show member pathways
9.1FASLG, FAS, TNF
26
Show member pathways
9.1IL10, IFNG, CCR5, TNF
27
Show member pathways
IL2 signaling events mediated by STAT536
9.0FASLG, IL2RA, IL2RB, LTA
28
Show member pathways
8.9CXCR3, CXCR1, CCR2, CCR5
29
Show member pathways
8.9CXCR3, CXCR1, CCR2, CCR5
30
Show member pathways
Ras signaling in the CD4+ TCR pathway36
8.8TNF, FASLG, IFNG, IL2RA, IL2RB
31
Show member pathways
Immune response CD16 signaling in NK cells58
8.8TNF, FAS, FASLG, IFNG
32
Show member pathways
8.7LTA, FASLG, FAS, TNF
33
Show member pathways
8.7TNF, FAS, FASLG, LTA
34
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.7LTA, FASLG, FAS, TNF
35
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.6FASLG, CCR5, IFNG, IL2RA, IL2RB
36
Show member pathways
8.6TNF, IFNG, IL2RA, IL2RB, IL10, LTA
37
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5TNF, FAS, CCR5, IFNG, IL10
38
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.5LTA, IFNG, FASLG, FAS, TNF
39
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.4TNF, FAS, FASLG, IFNG, IL10
408.4TNF, FAS, FASLG, IFNG, IL10
41
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.3TNF, FAS, FASLG, CCR5, LTA
42
Show member pathways
7.8TNF, FAS, FASLG, IFNG, IL2RA, IL2RB
43
Show member pathways
7.8TNF, FAS, FASLG, IFNG, IL2RA, IL10
447.8FAS, FASLG, CCR2, IL2RA, IL2RB, IL10
45
Show member pathways
7.8IL10, IL2RB, IL2RA, IFNG, FASLG, FAS
46
Show member pathways
7.6TNF, CXCR3, CCR2, CCR5, IL2RA, IL2RB
47
Show member pathways
7.6TNF, LTA, IL10, IL2RB, IL2RA, CCR5
48
Show member pathways
7.6IL10, IL2RB, IL2RA, CCR5, CCR2, CXCR3
49
Show member pathways
5.8LTA, TNF, FAS, FASLG, IL10, IL2RB

Compounds for genes affiliated with Uveitis

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Compounds related to Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1natalizumab43 1210.6IFNG, IL10, IL2RA, TNF
2interferon gamma439.5IFNG, IL10, TNF
3ccl11289.4CXCR3, CCR2, CCR5
4con a439.4IFNG, IL2RA, IL10, IL2RB
5ccl13289.4CXCR3, CCR2, CCR5
6ccl7289.4CCR5, CXCR3, CCR2
7imiquimod43 59 28 1212.3TNF, FASLG, IFNG, IL10
82,5-oligoadenylate439.3TNF, IFNG, IL2RB, IL2RA, IL10
9groalpha439.1IL10, CCR5, CXCR1, CXCR3, TNF
10thalidomide43 49 59 1212.1IFNG, FASLG, TNF, IL10, IL2RA
11mycophenolate mofetil43 49 1211.0IFNG, LTA, IL10, IL2RB, IL2RA, TNF
12pentoxifylline43 1210.0IL10, IL2RB, TNF, LTA, IFNG, IL2RA
13neopterin439.0IL2RA, IL2RB, IFNG, LTA, IL10, TNF
14etanercept43 49 1210.9IL2RB, IL10, LTA, IFNG, TNF, CXCR3
15tarc438.9IFNG, CXCR3, IL10, CCR5, TNF, CXCR1
16ccl343 289.9IL10, IFNG, CCR5, CXCR1, CXCR3, TNF
17calcitriol43 59 24 1211.8LTA, IL2RA, IL10, IFNG, TNF
18herbimycin a43 599.8TNF, CXCR1, LTA, IL2RA, IFNG, FAS
19ribavirin43 49 1210.7IL10, CXCR3, CCR5, IFNG
20methotrexate49 43 1210.7TNF, FASLG, IL2RA, IL10, IL2RB
21simvastatin43 49 59 28 24 1213.7FASLG, IFNG, CCR5, IL10, TNF
22indomethacin43 28 59 1211.5IL2RA, LTA, FAS, FASLG, IFNG, TNF
23morphine43 49 28 1211.5FASLG, FAS, IL2RB, CCR5, SAG
24histamine43 28 2410.5IL10, CXCR3, IL2RB, IL2RA, IFNG, CCR5
25tgf beta1438.5FASLG, FAS, LTA, IL10, TNF
26tacrolimus43 49 1210.5FASLG, CXCR3, TNF, IL2RA, IFNG, IL2RB
27okt3438.4LTA, IL10, IL2RB, IFNG, FAS, TNF
28prednisolone43 28 1210.4FAS, IFNG, IL2RA, IL2RB, IL10, LTA
29il 10438.2TNF, LTA, IL10, IL2RB, IL2RA, IFNG
30genistein43 28 59 2 24 1213.2FAS, FASLG, CXCR1, IL2RB, TNF, IFNG
31paraffin438.1FAS, IL10, IL2RA, SAG, LTA, FASLG
32ifn-alpha438.1FASLG, CXCR3, IFNG, IL2RA, IL2RB, IL10
33endotoxin438.1CXCR1, CXCR3, IFNG, IL10, IL2RB, FASLG
34infliximab43 49 1210.1FAS, IL10, IL2RB, IL2RA, IFNG, CXCR3
35actinomycin d438.0CCR5, LTA, TNF, IFNG, CXCR1, FAS
36rapamycin437.9FASLG, CCR5, IFNG, IL2RA, IL2RB, IL10
37aspartate437.9CCR5, SAG, FASLG, IL2RB, IL10, IL2RA
38ionomycin437.9IFNG, IL2RA, FASLG, FAS, TNF, LTA
39thymidine43 248.8CXCR3, FASLG, TNF, FAS, IFNG, IL2RA
40butyrate437.8FASLG, TNF, FAS, CCR5, IFNG, RBP3
41pge2437.5LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
42rantes437.4FAS, FASLG, CXCR3, CXCR1, CCR5, IFNG
43tyrosine437.3FASLG, SAG, CXCR3, CXCR1, IL2RA, IL2RB
44vegf437.2LTA, IL10, IL2RA, IFNG, CXCR1, CXCR3
45cyclosporin a43 28 599.1LTA, IL10, IL2RB, IL2RA, IFNG, CCR5
46ivig437.1IL2RA, LTA, IL10, IL2RB, IFNG, CCR5
47cycloheximide437.0LTA, IL2RB, RBP3, IL10, TNF, IFNG
48nitric oxide43 24 128.9RBP3, IL2RB, IL10, LTA, IFNG, CXCR3
49retinoic acid43 247.9CXCR1, FASLG, IL2RB, RBP3, CCR5, LTA
50dexamethasone43 49 28 129.8TNF, FAS, FASLG, CXCR3, CXCR1, CCR5

GO Terms for genes affiliated with Uveitis

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Cellular components related to Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.7TNF, FASLG, IFNG, IL10, RBP3, LTA
2integral component of plasma membraneGO:00058877.7TNF, FASLG, CXCR3, CCR2, CCR5, IL2RB
3external side of plasma membraneGO:00098977.4IL2RB, TNF, FAS, FASLG, CXCR3, CCR5
4plasma membraneGO:00058867.4FAS, CXCR3, CXCR1, CCR2, CCR5, IL2RA

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.4TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IFNG, TNF
3positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.3TNF, LTA
4positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
5positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.2LTA, TNF
6receptor biosynthetic processGO:003280010.2IL10, TNF
7negative regulation of cytokine secretion involved in immune responseGO:000274010.2IL10, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:005104410.2TNF, IFNG
9positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
10positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL10
11protein import into nucleus, translocationGO:000006010.1IFNG, TNF
12negative regulation of interleukin-6 productionGO:003271510.0TNF, IL10
13activation-induced cell death of T cellsGO:000692410.0IL2RA, FAS
14humoral immune responseGO:000695910.0LTA, IFNG, TNF
15positive regulation of nitric oxide biosynthetic processGO:00454299.9TNF, IFNG
16positive regulation of cytokine secretionGO:00507159.9IL10, TNF
17transformed cell apoptotic processGO:00069279.9TNF, FAS
18response to activityGO:00148239.9IL10, TNF
19defense response to Gram-positive bacteriumGO:00508309.9LTA, TNF
20calcium-mediated signalingGO:00197229.8CCR5, CXCR3, TNF
21positive regulation of interferon-gamma productionGO:00327299.8TNF, CCR2, LTA
22positive regulation of monocyte chemotaxisGO:00900269.8CCR2, CCR5
23inflammatory cell apoptotic processGO:00069259.7FAS, FASLG
24negative regulation of T cell proliferationGO:00421309.7IL2RA, IL10
25cellular response to lipopolysaccharideGO:00712229.7CCR5, IFNG, IL10
26negative regulation of growth of symbiont in hostGO:00441309.6TNF, IFNG, IL10, LTA
27dendritic cell chemotaxisGO:00024079.6CCR5, CCR2, CXCR1
28chemokine-mediated signaling pathwayGO:00700989.6CCR5, CCR2, CXCR1
29regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.6FAS, FASLG
30response to glucocorticoidGO:00513849.5IL10, FAS, TNF
31response to drugGO:00424939.5TNF, IFNG, IL10, LTA
32necroptotic signaling pathwayGO:00975279.5TNF, FAS, FASLG
33negative regulation of angiogenesisGO:00165259.5FASLG, CXCR3, CCR2
34extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5FASLG, FAS, TNF
35positive regulation of cytosolic calcium ion concentrationGO:00072049.5CCR5, CCR2, CXCR3
36activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4FASLG, FAS, TNF
37apoptotic signaling pathwayGO:00971909.3FASLG, FAS, TNF
38chemotaxisGO:00069359.3CXCR3, CXCR1, CCR2, CCR5
39extrinsic apoptotic signaling pathwayGO:00971919.2IFNG, FASLG, FAS, TNF
40cell-cell signalingGO:00072679.1FASLG, CCR5, IL10, LTA
41positive regulation of apoptotic processGO:00430659.1TNF, FAS, FASLG, LTA
42cell surface receptor signaling pathwayGO:00071669.0IL2RA, IFNG, CCR5, CXCR1, CXCR3, SAG
43immune responseGO:00069559.0FASLG, CCR2, CCR5, IL2RA
44cytokine-mediated signaling pathwayGO:00192219.0IL2RB, IFNG, CCR2
45inflammatory responseGO:00069548.6TNF, CXCR3, CXCR1, CCR2, CCR5, IL10
46apoptotic processGO:00069158.3TNF, FAS, FASLG, CXCR3, IFNG, IL2RA

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:00049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:00199769.6IL2RB, IL2RA
3C-C chemokine receptor activityGO:00164939.5CCR5, CCR2
4tumor necrosis factor receptor bindingGO:00051649.4TNF, FASLG, LTA
5chemokine receptor activityGO:00049509.0CCR5, CCR2, CXCR1, CXCR3
6cytokine activityGO:00051258.7TNF, FASLG, IFNG, IL10, LTA

Products for genes affiliated with Uveitis

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Sources for Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet