MCID: UVT001
MIFTS: 57

Uveitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Uveitis

MalaCards integrated aliases for Uveitis:

Name: Uveitis 12 29 52 42 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13141
ICD10 33 H20.9
MeSH 42 D014605
NCIt 47 C26909
UMLS 69 C0042164

Summaries for Uveitis

MalaCards based summary : Uveitis is related to fuchs' heterochromic uveitis and choroiditis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluocinolone Acetonide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Wikipedia : 72 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 557)
id Related Disease Score Top Affiliating Genes
1 fuchs' heterochromic uveitis 33.4 ICAM1 IFNG IL4 TNF
2 choroiditis 32.5 CCL2 IL10 TNF
3 cytomegalovirus retinitis 30.9 CCL2 ICAM1
4 bartonellosis 30.0 IFNG IL10 TNF
5 leptospirosis 29.9 IL17A NOD2 TNF
6 sinusitis 29.8 CCL2 IL1A TNF
7 tularemia 29.6 IFNG IL10 IL4 TNF
8 alopecia 29.5 CCL2 ICAM1 IL10 TNF
9 primary biliary cirrhosis 29.2 IL10 IL1A IL1R1 TNF
10 chickenpox 29.2 CCL2 HLA-B ICAM1 IFNA2 TNF
11 autoimmune retinopathy 29.1 CTLA4 IL2RA TNF
12 chronic graft versus host disease 29.1 CTLA4 IFNG IL10
13 lymphoma 28.4 CTLA4 IFNG IL10 IL17A IL4 TNF
14 churg-strauss syndrome 27.8 CXCR3 ICAM1 IFNG IL10 IL17A IL4
15 rheumatoid arthritis 26.2 CCL2 CTLA4 HLA-B ICAM1 IFNG IL10
16 systemic lupus erythematosus 26.1 CCL2 CTLA4 CXCR3 ICAM1 IFNG IL10
17 intermediate uveitis 12.2
18 tubulointerstitial nephritis with uveitis 12.2
19 posterior uveitis 12.0
20 anterior uveitis 11.9
21 infectious anterior uveitis 11.9
22 phacoanaphylactic uveitis 11.9
23 tuberculous uveitis 11.8
24 idiopathic anterior uveitis 11.8
25 blau syndrome 11.8
26 infectious posterior uveitis 11.8
27 idiopathic posterior uveitis 11.8
28 infantile onset panniculitis with uveitis and systemic granulomatosis 11.8
29 suppurative uveitis 11.7
30 paraneoplastic uveitis 11.7
31 pars planitis 11.7
32 sympathetic ophthalmia 11.6
33 panuveitis 11.3
34 birdshot chorioretinopathy 11.3
35 iridocyclitis 11.1
36 iritis 11.1
37 retinal vasculitis 11.0
38 chorioretinitis 11.0
39 acute posterior multifocal placoid pigment epitheliopathy 11.0
40 multifocal choroiditis 11.0
41 orbital lymphoma 11.0
42 vitreoretinopathy, neovascular inflammatory 10.9
43 pure autonomic failure 10.9 IL10 TNF
44 autoinflammatory syndrome, familial, behcet-like 10.8
45 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.8 HLA-B IFNG TNF
46 amyotrophic lateral sclerosis type 10 10.8 IFNG NOD2 TNF
47 crohn's colitis 10.7 IL2RA NOD2 TNF
48 plantar wart 10.7 IFNG IL10 TNF
49 membranoproliferative glomerulonephritis 10.7 IFNG NOD2 TNF
50 sternal cleft 10.7 IFNG TNF

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to Uveitis

Symptoms & Phenotypes for Uveitis

GenomeRNAi Phenotypes related to Uveitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.33 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.33 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.33 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.33 IL1R1 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.33 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.33 IL1R1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.33 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.33 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.33 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.33 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.33 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.33 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.33 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.33 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.33 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.33 IL1R1 IFNA2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.33 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.33 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.33 IFNA2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.33 IL1R1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.33 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.33 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.33 IL10 IL1R1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.33 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.33 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.33 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.33 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.33 IL2RA IL10 IL1R1 IFNA2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.33 IFNA2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.33 IL2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.33 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.33 IL10 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.33 IL2RA IL10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.33 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.33 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.33 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.33 IL1R1 IL2RA
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.33 IL1R1
39 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2
40 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2

MGI Mouse Phenotypes related to Uveitis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 IL1A IL1R1 IL2RA IL4 NOD2 TGFB2
2 homeostasis/metabolism MP:0005376 10.28 CTLA4 CXCR3 ICAM1 IFNG IL10 IL17A
3 immune system MP:0005387 10.27 CAPN5 CCL2 CTLA4 CXCR3 ICAM1 IFNG
4 growth/size/body region MP:0005378 10.23 IL2RA IL4 NOD2 TGFB2 TNF TRIB2
5 digestive/alimentary MP:0005381 10.19 CTLA4 ICAM1 IFNG IL10 IL17A IL2RA
6 endocrine/exocrine gland MP:0005379 10.18 CTLA4 ICAM1 IFNG IL10 IL17A IL1R1
7 mortality/aging MP:0010768 10.17 CAPN5 CTLA4 CXCR3 ICAM1 IFNG IL10
8 craniofacial MP:0005382 10.05 IFNG IL10 IL17A IL1R1 IL4 TGFB2
9 respiratory system MP:0005388 9.85 CTLA4 CXCR3 IFNG IL10 IL17A IL1R1
10 neoplasm MP:0002006 9.8 IFNG IL10 IL1A IL1R1 TNF CXCR3
11 skeleton MP:0005390 9.61 CTLA4 IFNG IL10 IL17A IL1R1 IL4
12 vision/eye MP:0005391 9.32 TGFB2 TNF ICAM1 IFNG IL10 IL1R1

Drugs & Therapeutics for Uveitis

Drugs for Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
3
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
7
Apraclonidine Approved Phase 4 66711-21-5 2216
8
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
9
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
10
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
11
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
12
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
13
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
14
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 90-82-4 7028
15
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
16
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
17
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
18
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
19
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
20
Adalimumab Approved Phase 4,Phase 2,Phase 3,Phase 1 331731-18-1 16219006
21 Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
22
Chlorambucil Approved Phase 4 305-03-3 2708
23
Cyclophosphamide Approved, Investigational Phase 4,Phase 2 50-18-0, 6055-19-2 2907
24
Daclizumab Approved, Investigational Phase 4,Phase 2,Phase 1 152923-56-3
25
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
26
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
27
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
28
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
29
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
30
Travoprost Approved Phase 4 157283-68-6 5282226
31
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
32
Certolizumab pegol Approved Phase 4 428863-50-7
33
Nepafenac Approved Phase 4 78281-72-8 151075
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
36
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
37
Maleic acid Experimental Phase 4 110-16-7 444266
38
Lactitol Investigational Phase 4 585-86-4 3871
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
45 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
46 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
47 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
48 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
49 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Gentamicins Phase 4

Interventional clinical trials:

(show top 50) (show all 350)

id Name Status NCT ID Phase Drugs
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
2 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
3 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
4 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4
5 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
6 Multi Center Prospective Registry of Infliximab Use for Childhood Uveitis Completed NCT00589628 Phase 4 infliximab;infliximab
7 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
8 Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Completed NCT00543296 Phase 4 0.59 mg Fluocinolone Acetonide implant
9 Corneal Specular Microscopy in Infectious and Noninfectious Uveitis Completed NCT00789984 Phase 4
10 TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema Completed NCT01870440 Phase 4 Ozurdex Intravitreal Injection (0.7 mg)
11 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4 Prednisolone acetate
12 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
13 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
14 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
15 Steroids After Laser Trabeculoplasty for Glaucoma Completed NCT00981435 Phase 4 Prednisolone 1%;Diclofenac 0.1%;Artificial Tears
16 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4 ranibizumab
17 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4 Hydroxypropylmethylcellulose;Carboxymethylcellulose
18 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
19 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
20 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
21 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Recruiting NCT03020992 Phase 4 Certolizumab Pegol
22 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
23 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
24 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Recruiting NCT01827722 Phase 4 Ozurdex;Ranibizumab;Combination Ozurdex with Ranibizumab PRN
25 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Recruiting NCT02684084 Phase 4 Ozurdex;Lucentis
26 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Recruiting NCT02897115 Phase 4
27 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Recruiting NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
28 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Not yet recruiting NCT02769702 Phase 4 Acthar
29 Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema Not yet recruiting NCT02598869 Phase 4 Triamcinolone Acetonide
30 Topical Treatment for Uveitic Macular Edema Not yet recruiting NCT01939691 Phase 4 Difluprednate 0.05% ophthalmic emulsion;Nepafenac 0.1% ophthalmic solution;Prednisolone acetate 1% ophthalmic suspension
31 PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial Suspended NCT02374060 Phase 4 Periocular triamcinolone 40 mg;Intravitreal triamcinolone 4 mg;Dexamethasone intravitreal implant
32 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4 Thalidomide
33 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4 Methotrexate;Placebo
34 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
35 Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial) Unknown status NCT00348153 Phase 2, Phase 3 Adalimumab
36 The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis Unknown status NCT00012506 Phase 3 TNFR:Fc
37 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
38 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
39 Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema Unknown status NCT01523314 Phase 2, Phase 3 dexamethasone - Cyclodextrin eye drops
40 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
41 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
42 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3 ranibizumab
43 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
44 Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
45 First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial Completed NCT01232920 Phase 3 Methotrexate;Mycophenolate mofetil
46 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
47 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
48 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
49 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
50 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: uveitis

Genetic Tests for Uveitis

Genetic tests related to Uveitis:

id Genetic test Affiliating Genes
1 Uveitis 29

Anatomical Context for Uveitis

MalaCards organs/tissues related to Uveitis:

39
Eye, T Cells, Endothelial, Retina, Testes, Skin, Neutrophil

Publications for Uveitis

Articles related to Uveitis:

(show top 50) (show all 2255)
id Title Authors Year
1
Bilateral posterior uveitis associated with Zika virus infection. ( 27939402 )
2017
2
Prevalence of Anti-infliximab Antibodies and Their Associated Co-factors in Children with Refractory Arthritis and/or Uveitis: A Retrospective Longitudinal Cohort Study. ( 28089968 )
2017
3
PERIPHERAL RETINOSCHISIS IN INTERMEDIATE UVEITIS. ( 28590967 )
2017
4
Rosai-Dorfman disease and uveitis. ( 28943506 )
2017
5
Stalagmite-like preretinal inflammatory deposits in vitrectomized eyes with posterior uveitis. ( 28924415 )
2017
6
An unusual case of bilateral anterior uveitis related to moxifloxacin: the first report in Latin America. ( 28706771 )
2017
7
Long-term Change of Subfoveal Choroidal Thickness in BehAset's Disease Patients with Posterior Uveitis. ( 28080153 )
2017
8
Fibrinous anterior uveitis and recurrent epithelial erosion following topical tetracaine abuse. ( 28521706 )
2017
9
Retinal pigmentary changes in chronic uveitis mimicking retinitis pigmentosa. ( 28523457 )
2017
10
Cytomegalovirus Anterior Uveitis Following Topical Cyclosporine A. ( 28448732 )
2017
11
Anticentromere antibody positive Ackerman's Syndrome with Granulomatous Anterior Uveitis. ( 28605750 )
2017
12
Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma. ( 28394239 )
2017
13
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
14
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
15
Long-term results of cataract surgery in patients with anterior uveitis. ( 28602016 )
2017
16
LONG-TERM OUTCOMES OF RITUXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS POSTERIOR UVEITIS REFRACTORY TO CONVENTIONAL IMMUNOSUPPRESSIVE THERAPY. ( 28225369 )
2017
17
Simvastatin as an Adjunct to Conventional Therapy of Non-infectious Uveitis: A Randomized, Open-Label Pilot Study. ( 28937830 )
2017
18
Development and evaluation of multiplex real-time PCR for diagnosis of HSV-1, VZV, CMV, and Toxoplasma gondii in patients with infectious uveitis. ( 28911798 )
2017
19
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
20
FOXP3(+) T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome. ( 28894974 )
2017
21
Ocular Self-Microemulsifying Drug Delivery System of Prednisolone Improves Therapeutic Effectiveness in the Treatment of Experimental Uveitis. ( 28910554 )
2017
22
In response to: "Gautam N, Singh R, Agarwal A, et al. Pattern of Pediatric Uveitis at a Tertiary Referral Institute in North India". ( 28075200 )
2017
23
Viral Posterior Uveitis-Author's reply. ( 28606632 )
2017
24
Multimodal Imaging in Anterior Uveitis. ( 28696173 )
2017
25
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
26
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
27
AJKD Atlas of Renal Pathology: Tubulointerstitial Nephritis WithA Uveitis. ( 28532639 )
2017
28
Preoperative Inflammatory Control and Surgical Outcome of Vitrectomy in Intermediate Uveitis. ( 28465834 )
2017
29
Listeria Monocytogenes Endophthalmitis after Intermediate Uveitis and ppV for Retinal Detachment. ( 28329887 )
2017
30
Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )
2017
31
Peripheral blood monocytes reveal an activated phenotype in pediatric uveitis. ( 28923439 )
2017
32
An Update on Treatment of Pediatric Chronic Non-Infectious Uveitis. ( 28944162 )
2017
33
Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis. ( 28091550 )
2017
34
Cytomegalovirus retinitis followed by immune recovery uveitis in an elderly patient with rheumatoid arthritis undergoing administration of methotrexate and tofacitinib combination therapy. ( 28389165 )
2017
35
Re: Niederer etA al.: Predictors of long-term visual outcome in intermediate uveitis (Ophthalmology. 2017;124:393-398). ( 28645347 )
2017
36
Uveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey. ( 28070763 )
2017
37
Correction: Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis. ( 28069759 )
2017
38
Acute Bilateral Anterior Uveitis after a Single Intravenous Infusion of Zoledronic Acid in Metastatic Breast Cancer. ( 28682020 )
2017
39
Epidemiological profile of patients with uveitis in Boko and Parakou, in northern BAcnin. ( 28947410 )
2017
40
Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine. ( 28924192 )
2017
41
Anterior segment optical coherence tomography and retained vegetal intraocular foreign body masquerading as chronic anterior uveitis. ( 28536985 )
2017
42
Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment. ( 28862736 )
2017
43
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. ( 28195080 )
2017
44
Successful ustekinumab treatment of noninfectious uveitis and concomitant severe psoriatic arthritis and plaque psoriasis. ( 28833973 )
2017
45
Morphometric features on enhanced depth imaging optical coherence tomography scans in idiopathic posterior uveitis or panuveitis. ( 28585111 )
2017
46
Phacoemulsification and Core Vitrectomy in Fuchs' Heterochromic Uveitis. ( 28638250 )
2017
47
A Prostacyclin Analog, Cicaprost, Exhibits Potent Anti-Inflammatory Activity in Human Primary Immune Cells and a Uveitis Model. ( 28072560 )
2017
48
The Effectiveness of Pre- and Postoperative Infliximab in Controlling BehAset's Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study. ( 28484648 )
2017
49
Reply to Lee and colleagues-Viral posterior uveitis. ( 28624250 )
2017
50
Re: Maleki etA al.: Selective laser trabeculoplasty in controlled uveitis with steroid-induced glaucoma (Ophthalmology. 2016;123:2630-2632). ( 28734340 )
2017

Variations for Uveitis

Expression for Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for Uveitis

Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CCL2 CTLA4 HLA-B ICAM1 IFNA2 IFNG
2
Show member pathways
13.92 CAPN5 CCL2 CXCR3 IL10 IL17A IL1A
3
Show member pathways
13.74 CCL2 CXCR3 IFNA2 IFNG IL10 IL17A
4
Show member pathways
13.61 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
5
Show member pathways
13.51 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
6
Show member pathways
13.39 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
7
Show member pathways
13.38 CCL2 HLA-B ICAM1 IFNA2 IFNG IL10
8
Show member pathways
13.04 CCL2 IFNA2 IL1A IL1R1 NOD2 TNF
9
Show member pathways
12.95 CCL2 IFNA2 IFNG IL10 TGFB2 TNF
10
Show member pathways
12.88 CCL2 HLA-B ICAM1 IFNA2 IFNG IL1A
11
Show member pathways
12.74 CTLA4 HLA-B ICAM1 IFNA2 IFNG IL10
12
Show member pathways
12.69 IFNG IL10 IL2RA IL4 TNF
13
Show member pathways
12.65 CCL2 IFNG IL10 IL17A TNF
14
Show member pathways
12.63 HLA-B ICAM1 IFNA2 IFNG IL4 TNF
15 12.58 CCL2 CTLA4 IFNG IL10 IL17A IL2RA
16
Show member pathways
12.56 IFNG IL10 IL17A IL1A IL1R1 IL2RA
17 12.55 HLA-B ICAM1 IL1R1 IL2RA TGFB2 TNF
18
Show member pathways
12.53 CTLA4 IFNG IL10 IL17A IL1A IL4
19
Show member pathways
12.43 CCL2 IFNG IL17A IL4 TNF
20
Show member pathways
12.37 IFNG IL10 IL1A IL4 TGFB2 TNF
21
Show member pathways
12.35 CCL2 IL1A IL1R1 NOD2
22 12.34 HLA-B ICAM1 IFNG IL10
23 12.34 IFNA2 IFNG IL10 IL1A NOD2 TGFB2
24
Show member pathways
12.32 IFNG IL1A IL1R1 TNF
25
Show member pathways
12.32 IFNA2 IFNG IL10 IL2RA IL4
26
Show member pathways
12.24 IFNG IL1R1 IL4 TNF
27 12.2 CCL2 ICAM1 IFNG IL1A IL1R1 TNF
28 12.18 IFNG IL1A IL1R1 TGFB2 TNF
29
Show member pathways
12.18 HLA-B IFNA2 IFNG IL10 IL17A IL1A
30 12.13 CCL2 ICAM1 IFNG IL1A IL1R1 IL4
31 12.11 IFNA2 IFNG IL10 IL2RA IL4 TNF
32 12.1 CCL2 ICAM1 IL10 IL17A IL1A IL4
33
Show member pathways
12.06 IFNG IL1R1 IL2RA IL4
34 12.04 CCL2 ICAM1 NOD2 TNF
35 12.04 CCL2 ICAM1 IL1A TGFB2 TNF
36
Show member pathways
12.04 IFNG IL17A IL1R1 IL4 TGFB2
37
Show member pathways
12.03 IFNG IL10 IL17A TNF
38 12.03 IL1A IL1R1 IL2RA IL4 TNF
39 12.02 IFNG IL10 IL1R1 TGFB2 TNF
40 11.96 IFNA2 IFNG IL10 IL2RA
41
Show member pathways
11.88 CTLA4 IFNG IL2RA IL4 TNF
42 11.87 IFNA2 IFNG IL10 TNF
43 11.84 IFNG TGFB2 TNF
44 11.83 ICAM1 IFNG IL4
45 11.8 IL10 IL1A TNF
46 11.79 CTLA4 ICAM1 IL10 IL2RA IL4 TGFB2
47
Show member pathways
11.78 ICAM1 IFNG IL1A TNF
48 11.71 CCL2 IL4 TNF
49
Show member pathways
11.69 IFNG IL2RA TNF
50 11.64 IL1A IL1R1 TNF

GO Terms for Uveitis

Cellular components related to Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
2 cell surface GO:0009986 9.56 CAPN5 CXCR3 HLA-B ICAM1 IL1R1 IL2RA
3 external side of plasma membrane GO:0009897 9.23 CTLA4 CXCR3 ICAM1 IFNG IL17A IL2RA
4 extracellular region GO:0005576 10 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.98 HLA-B ICAM1 IFNG IL4
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL2 ICAM1 NOD2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.93 CCL2 IFNA2 IL1A IL1R1
4 response to drug GO:0042493 9.91 CCL2 ICAM1 IFNG IL10 IL4 TGFB2
5 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 NOD2 TNF
6 cellular response to interleukin-1 GO:0071347 9.88 CCL2 ICAM1 IL17A
7 regulation of inflammatory response GO:0050727 9.88 IL1R1 IL4 NOD2
8 interferon-gamma-mediated signaling pathway GO:0060333 9.87 HLA-B ICAM1 IFNG
9 response to glucocorticoid GO:0051384 9.87 CCL2 IL10 TNF
10 B cell differentiation GO:0030183 9.87 IFNA2 IL10 IL4
11 neutrophil chemotaxis GO:0030593 9.86 CCL2 IFNG TGFB2
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 IFNA2 IFNG IL4
13 positive regulation of T cell proliferation GO:0042102 9.85 IFNG IL2RA IL4
14 positive regulation of tumor necrosis factor production GO:0032760 9.82 CCL2 IFNG NOD2
15 positive regulation of cell adhesion GO:0045785 9.82 CCL2 IFNG TNF
16 positive regulation of interleukin-6 production GO:0032755 9.81 IL1A NOD2 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 ICAM1 IFNG TNF
18 extrinsic apoptotic signaling pathway GO:0097191 9.79 IFNG TGFB2 TNF
19 negative regulation of T cell proliferation GO:0042130 9.77 CTLA4 IL10 IL2RA
20 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
21 cellular response to lipopolysaccharide GO:0071222 9.72 CCL2 ICAM1 IFNG IL10 TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 TNF
23 glial cell migration GO:0008347 9.71 CCL2 TGFB2
24 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IFNG IL4
25 positive regulation of cytokine secretion GO:0050715 9.71 IL10 IL1A TNF
26 humoral immune response GO:0006959 9.71 CCL2 IFNA2 IFNG TNF
27 cell surface receptor signaling pathway GO:0007166 9.7 CCL2 CXCR3 IFNA2 IFNG IL1R1 IL2RA
28 defense response to protozoan GO:0042832 9.69 IFNG IL10 IL4
29 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
30 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG IL17A TNF
31 positive regulation of cellular extravasation GO:0002693 9.66 CCL2 ICAM1
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.66 ICAM1 TNF
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
34 type 2 immune response GO:0042092 9.65 IL10 IL4
35 negative regulation of growth of symbiont in host GO:0044130 9.65 IFNG IL10 TNF
36 positive regulation of interleukin-23 production GO:0032747 9.63 IFNG IL17A
37 negative regulation of immune response GO:0050777 9.63 CTLA4 IL2RA TGFB2
38 positive regulation of neutrophil extravasation GO:2000391 9.61 IL1A IL1R1
39 regulation of isotype switching GO:0045191 9.61 IL10 IL4
40 positive regulation of mononuclear cell migration GO:0071677 9.6 IL4 TNF
41 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
43 regulation of complement-dependent cytotoxicity GO:1903659 9.57 IL10 TGFB2
44 negative regulation of alkaline phosphatase activity GO:0010693 9.56 TGFB2 TNF
45 inflammatory response GO:0006954 9.56 CCL2 CXCR3 IFNA2 IL10 IL17A IL1A
46 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IFNG IL4 TNF
47 positive regulation of vitamin D biosynthetic process GO:0060557 9.52 IFNG TNF
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 IFNG IL10 IL4
49 immune response GO:0006955 9.36 CCL2 CTLA4 HLA-B IFNG IL10 IL17A
50 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.21 IFNG IL10 IL17A IL1A IL4 NOD2

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Sources for Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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