Uveitis malady

Wikipedia: Uveitis specifically refers to inflammation of the middle layer of the eye, termed the \"uvea\" but in...⁴⁴ more...

MalaCards: Uveitis, also known as uveitis (disorder), is related to anterior uveitis and posterior uveitis. An important gene associated with Uveitis is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Bacterial infections in CF airways and Immune System. The drugs atropine methylnitrate and atropine sulfate and the compounds ivig and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and monocytes, and related mouse phenotypes are hematopoietic system and respiratory system.

Aliases & Descriptions:

uveitis 6 8 32 43 uveitis (disorder) 6

uveitis, nos 6 uveitis nos 6

Diseases related to uveitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	anterior uveitis	36.3	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
2	posterior uveitis	34.6	SAG, IL2RA, IL2RB
3	intermediate uveitis	34.0	IL2RA, CCR4, CCR5, CXCR3
4	arthritis	32.0	SELL, SERPINA1, MMP3, IL17A, IL1A, IL1B
5	pars planitis	32.0	IL1RN, HLA-A, HLA-B, HLA-DRB1
6	blau syndrome	31.8	IL10, IL1B, TNF, NOD2, DPEP1
7	rheumatoid arthritis	31.3	IL1R1, IL1RN, HLA-DRB1, TNFRSF1A, CRP, LTA
8	sympathetic ophthalmia	31.1	IL10, CCL2, HLA-C, HLA-DQA1, HLA-DRB1, TNF
9	behcet's disease	30.9	KIR2DL1, KIR3DL1, RBP3, SELE, SELL, SAG
10	ankylosing spondylitis	30.6	SERPINA1, CD79A, CD40LG, MMP3, IL17A, IL1R1
11	tubulointerstitial nephritis and uveitis	30.0	HLA-DQA1, HLA-DQB1, HLA-DRB1
12	panuveitis	29.9	IL10, IFNA1, IFNA2, TNF
13	scleritis	29.3	IL4, IL5, CCL2, IFNG, HLA-B, TNF
14	birdshot chorioretinopathy	28.9	KIR2DS3, KIR2DL1, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DS2
15	spondyloarthropathy	28.5	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
16	juvenile rheumatoid arthritis	28.5	S100A8, IL18R1, IL1A, IL1R1, IL1RN, IL2RA
17	cytomegalovirus retinitis	28.3	IL2, FASLG, CCR2, CCR5, IFNG, HLA-A
18	iritis	28.3	MRAP, CD79A, CD40LG, HLA-B
19	optic neuritis	28.3	RCVRN, SAG, CD40LG, IL10, IL2RA, IL5
20	neuritis	28.3	RCVRN, BMP6, SAG, S100A8, MPO, CD40LG
21	spondylarthropathy	28.2	S100A8, B2M, TNF, CRP, TLR4
22	intraocular lymphoma	28.0	IL10, IL4, IL6, CXCL12, CXCR4, CXCR5
23	crohn's disease	27.9	LCN2, MPO, MIF, IL10, IL13, IL17A
24	chorioretinitis	27.9	RBP3, SERPINF1, SAG, CD4, HLA-B, COL11A1
25	tuberculosis	27.7	CISH, IL10, IL1B, IL1RN, IL4, CCL2
26	multiple sclerosis	27.6	CD14, CD40, IL1A, IL1B, IL1RN, IL2RA
27	retinal vasculitis	27.5	SAG, APOH, CCL4, IFNA2, TNF, NOS2
28	t-cell leukemia	27.4	CD4, CD40, ITGA4, IL18R1, IL1A, IL2
29	cystoid macular edema	27.2	VEGFA, IL10, IFNG, HLA-B, CXCL10, CXCL12
30	endophthalmitis	27.1	VEGFA, SAG, IL8, IFNG, TNF, ELANE
31	gaucher's disease	27.0	CHIA, GUSB, CCL18, ADA, GBA
32	human t-cell leukemia virus type 1	26.8	IL13, IL15, IL1A, IL1B, IL2, IL2RA
33	kaposi's sarcoma	26.8	SELE, VEGFA, CD14, IL6, IFNA1, IFNA2
34	interstitial nephritis	26.7	B2M, IL2, ALB, HLA-DRB1, CRP, ACE
35	myasthenia gravis	25.7	CD79A, CD40LG, MMP3, IL10, IL15, IL17A
36	spondylitis	25.3	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
37	retinal detachment	25.2	SERPINF1, VEGFA, MMP3, IL6, CCL2, IFNG
38	proliferative diabetic retinopathy	24.6	SELE, SERPINF1, VEGFA, MIF, IL10, IL6
39	cholera	24.1	CKB, MPO, CD79A, CD4, CD40LG, IL10
40	cataract	24.1	SERPINF1, VEGFA, BMP6, MMP3, IL13, IL1A
41	sarcoidosis	23.8	KIR2DL3, SFTPD, RCVRN, SELE, SELL, VEGFA
42	encephalomyelitis	23.7	VEGFA, BMP6, SAG, S100A8, MPO, CD40LG
43	choroiditis	23.7	RCVRN, SELE, SERPINF1, VEGFA, BMP6, LCN2
44	retinitis	23.6	RCVRN, RBP3, SELE, SERPINF1, VEGFA, LMOD1
45	diabetic retinopathy	23.5	RBP3, SELE, SELL, SERPINF1, VEGFA, BMP6
46	nephritis	22.7	SELE, SERPINA1, VEGFA, BMP6, LCN2, S100A8
47	sarcoma	19.2	GC, SELE, SERPINA1, VEGFA, BMP6, LINC00328
48	melanoma	17.1	KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KIR2DL2, RCVRN
49	pneumonia	16.8	SFTPD, SELE, SELL, SERPINA1, VEGFA, BMP6
50	cerebritis	16.3	GC, SELE, SERPINA1, VEGFA, BMP6, CKB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 atropine, atropine methylnitrate, atropine sulfate

MalaCards organs/tissues related to uveitis:

²²

MGI Mouse Phenotypes related to uveitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.4	LCN2, CD69, MIF, IL17A, IL23A, PSMB9
2	respiratory system phenotype	MP:0005388	10.4	COL2A1, ADA, GBA, PTPN22, CCR4, SFTPD
3	other phenotype	MP:0005395	9.8	SOD2, CXCR3, TLR2, NOS2, TNFRSF1A, CCR2
4	integument phenotype	MP:0010771	9.3	TRIM21, TNFRSF1A, TNFRSF1B, CTLA4, TLR2, TLR4
5	skeleton phenotype	MP:0005390	9.2	GC, VEGFA, BMP6, CD69, TGFB2, CXCR4
6	vision/eye phenotype	MP:0005391	9.2	IL6, COL2A1, COL9A1, RHO, LTA, TLR4
7	no phenotypic analysis	MP:0003012	8.8	CCR5, HLA-C, RHO, KLRD1, POMC, PMEL
8	digestive/alimentary phenotype	MP:0005381	8.7	CCL3, IFNG, TRB@, CTLA4, NOD2, NOS2
9	tumorigenesis	MP:0002006	8.3	SELL, RANBP2, B2M, MIF, IL10, TRB@
10	muscle phenotype	MP:0005369	7.5	HLA-DQB1, TNF, TNFRSF1A, TNFRSF1B, NOS2, TLR2
11	growth/size phenotype	MP:0005378	7.0	PTPN22, TRB@, AKR1B1, HSPD1, HSPA1A, MAPK1
12	behavior/neurological phenotype	MP:0005386	6.6	LTA, COL2A1, NOS2, TNFRSF1B, TNFRSF1A, TNF
13	mortality/aging	MP:0010768	5.7	PTPN22, ADM, ADA, GBA, CXCR3, CXCL9
14	cellular phenotype	MP:0005384	4.7	HSP90AA1, RHO, LTA, EIF2AK3, ACE, TLR2
15	immune system phenotype	MP:0005387	INF	SELL, HSP90AA1, GJB6, HLA-C, HLA-DQA1, HLA-DQB1
16	renal/urinary system phenotype	MP:0005367	INF	ADM, SOD2, CXCR4, TGFB2, COL2A1,
17	adipose tissue phenotype	MP:0005375	INF	, NOS2, ACE, TLR2, TLR4, SOD2
18	endocrine/exocrine gland phenotype	MP:0005379	INF	IFNG, , CTLA4, LTA, TLR2, GAL
19	reproductive system phenotype	MP:0005389	INF	CCR5, IFNG, HSPD1, TNF, TNFRSF1A,
20	homeostasis/metabolism phenotype	MP:0005376	INF	IL18, CCR5, CCL3, IGHE, ICAM1, ALB
21	nervous system phenotype	MP:0003631	INF	TLR2, EIF2AK3, LTA, RHO, COL2A1, COL11A1
22	liver/biliary system phenotype	MP:0005370	INF	VEGFA, IL1R1, IL2, IL22, IL6, CCR2
23	cardiovascular system phenotype	MP:0005385	INF	IFNG, ACE, TLR2, TLR4, TIMP1, TGFB2

Articles related to uveitis:

(show top 50)    (show all 323)

id	Title	Authors	Year	Affiliating Genes
1	Uveitis in Blau syndrome from a de novo mutation of t he NOD2/CARD15 gene. (21596301)	Raiji V.R.... Jung L.K.	2011	NOD2
2	G/R 241 polymorphism of intercellular adhesion molecu le 1 (ICAM-1) is associated with Fuchs uveitis. (20445114)	Cimino L.... Cappuccini L.	2010	ICAM1
3	Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. (19098321)	Rosenzweig H.L.... Rosenbaum J.T.	2009	IFNG, DPEP1, NOD2
4	Cytokine profiles in toxoplasmic and viral uveitis. (19302012)	Lahmar I.... Candolfi E.	2009	IFNG, CCL4, IL17A
5	Antigen-dependent monophasic or recurrent autoimmune uveitis in rats. (18203685)	Diedrichs-MAPhring M.... Wildner G.	2008	SAG, RBP3
6	Equine recurrent uveitis--a spontaneous horse model of uveitis. (18421230)	Deeg C.A.... Ueffing M.	2008	RLBP1, RCVRN
7	Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor. (18469182)	Simon D.... Curnow S.J.	2008	IL6ST
8	Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)	Li J.Y.... Coates P.T.	2008	HLA-DQA1, HLA-DQB1, HLA-DRB1
9	NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. (18385071)	Rosenzweig H.L.... Rosenbaum J.T.	2008	SELL, DPEP1, NOD2
10	Effect of corticotherapy on interleukin-8 and -12 and nitric oxide production during BehAset and idiopathic uveitis (18563038)	Belguendouz H.... Touil-Boukoffa C.	2008	IL8
11	Tumor necrosis factor inhibitors and uveitis: comment on the article by Lim et al. (18438832)	Sfikakis P.P.... Markomichelakis N.	2008	TNF
12	Use of tumor necrosis factor inhibitors in uveitis. (17762615)	Rabinovich C.E.	2007	TNF
13	Th1 and Th2 responses on the ocular surface in uveitis identified by CCR4 and CCR5 conjunctival expression. (17686449)	Trinh L.... Baudouin C.	2007	CCR5, CCR4
14	Increased levels of pigment epithelium-derived factor in aqueous humor of patients with uveitis. (16973658)	Yoshida Y.... Yamakawa R.	2007	TNF, SERPINF1
15	Infectious uveitis in infancy: borreliosis, tuberculosis, lues (17594618)	Ness T.... Frosch M.	2007	IFNG
16	Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. (17400913)	Poulaki V.... Miller J.W.	2007	TNF, IL1B, HSP90AA1
17	Interferon-alpha as an effective treatment for noninfectious posterior uveitis and panuveitis. (17601428)	Plskova J.... Forrester J.V.	2007	IFNA1
18	Tuberculous uveitis after treatment with etanercept. (17364199)	Fonollosa A.... Garcia-Arumi J.	2007	TNF
19	Emerging biologics in the treatment of uveitis. (20477028)	Yeh S.... Levy-Clarke G.A.	2007	TNF
20	Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis. (16365158)	Crane I.J.... Forrester J.V.	2006	CCR5
21	Risk of new-onset uveitis in patients with juvenile idiopathic arthritis treated with anti-TNFalpha agents. (17137902)	Saurenmann R.K.... Silverman E.D.	2006	TNF
22	Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. (16901960)	Guignard S.... Dougados M.	2006	TNF
23	Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IFNgamma profiles in uveitis. (16384973)	Ooi K.G.... Calder V.L.	2006	TNF, IFNG, IL10
24	Polymorphisms within the tumor necrosis factor-alpha promoter region in patients with HLA-B27-associated uveitis: association with susceptibility and clinical manifestations. (16581430)	El-Shabrawi Y.... Hermann J.	2006	TNF
25	Production of Th1/Th2 cytokines and nitric oxide in BehAset's uveitis and idiopathic uveitis (16523155)	Guenane H.... Touil-Boukoffa C.	2006	IFNG, IL10
26	Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. (15713799)	Howard O.M.... Oppenheim J.J.	2005	CXCR3, SAG, CXCR5
27	Initial evaluation of subcutaneous daclizumab treatments for noninfectious uveitis: a multicenter noncomparative interventional case series. (15878055)	Nussenblatt R.B.... Buggage R.R.	2005	IL2RA
28	T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis. (15980237)	Damico F.M.... Yamamoto J.H.	2005	RANBP2, IL4
29	Chemokines and gelatinases in the aqueous humor of patients with active uveitis. (15364222)	Abu El-Asrar A.M.... Geboes K.	2004	CXCR3, CXCL11, CXCL6
30	Immunologic peculiarities of uveitis concurrent with systemic pathologies (15384843)	Drozdova E.A.... Alekhina T.V.	2004	IL4
31	Tumour necrosis factor-alpha levels in aqueous humour and serum from patients with uveitis: the involvement of HLA-B27. (15006008)	PAcrez-Guijo V.... Collantes-EstAcvez E.	2004	TNF
32	A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. (12697736)	Pennesi G.... Caspi R.R.	2003	SAG, RBP3
33	Induction of autoimmune encephalomyelitis and uveitis in B6 and (B6 x SJL) mice by peptides derived from myelin/oligodendrocyte glycoprotein. (12417441)	Shao H.... Sun D.	2002	MBP
34	Human retinal S-antigen: T cell epitope mapping in posterior uveitis patients. (11263956)	Rai G.... Singh V.K.	2001	SAG
35	The effects of intraocular injection of interleukin-13 on endotoxin-induced uveitis in rats. (11481267)	Lemaitre C.... de Kozak Y.	2001	IL13
36	Levels of soluble ICAM-1 and soluble IL-2R in the serum and aqueous humor of uveitis patients. (10806443)	Martin C.M.... Estevez E.C.	2000	ICAM1, IL2RA
37	Interdependency between titers of aniretinal antibodies and selected immune system parameters in serum of patients with endogenous posterior uveitis (11291296)	Kubicka-Trzaska A.	2000	CD40LG, CD79A, IGHE
38	Increased CD4+ expression and decreased IL-10 in the anterior chamber in idiopathic uveitis. (10440256)	Calder V.L.... Lightman S.	1999	IL10
39	Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog. (10415460)	Brito B.E.... Rosenbaum J.T.	1999	CCL3, CXCR1
40	Elevated serum levels of soluble ICAM-1 in uveitis pa tients predict underlying systemic disease. (10396209)	Whitcup S.M.... George R.K.	1999	ICAM1
41	Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27. (9744378)	Goto K.... Ohno S.	1998	HLA-B
42	Experimental autoimmune uveitis as animal model for h uman posterior uveitis. (9540278)	Singh V.K.... Agarwal S.S.	1998	RBP3
43	Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases. (8977222)	Guex-Crosier Y.... Roberge F.G.	1997	IL2, IL2RB, SAG
44	Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. (9152063)	Nussenblatt R.B.... Whitcup S.M.	1997	SAG
45	The use of interferon alfa-2r in the treatment of au toimmune uveitis (primary or associated with BehAset's disease) (8768028)	SA!nchez RomA!n J.... Wichmann I.	1996	IFNA2, IFNA1
46	Antibodies against retinal S-antigen in patients with juvenile chronic arthritis-associated uveitis. (8624615)	Edelsten C.... Woo P.	1996	SAG
47	Interleukin 2 receptor membrane bound and in soluble form in the aqueous humor and peripheral blood of patients with acute untreated uveitis. (1433001)	Scheinberg M.A.... Mota I.M.	1992	IL2RA
48	Molecular mimicry: uveitis induced in Macaca fascicularis by microbial protein having sequence homology with retinal S-antigen. (1635290)	Singh V.K.... Shinohara T.	1992	SAG
49	Circulating ICAM-1 levels in serum of uveitis patients. (1358555)	Arocker-Mettinger E.... Kuchar A.	1992	ICAM1
50	Histochemical analysis of experimental granulomatous uveitis. (1870844)	Kristeva M.... Rao N.A.	1991	GUSB

Genes related to uveitis according to GeneCards:

(show top 50)    (show all 166)

id	Symbol	Description	Score	GeneCards Section Context
1	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
2	TNF	tumor necrosis factor	11.0	Publications
3	SAG	S-antigen; retina and pineal gland (arrestin)	11.0	Publications
4	IFNG	interferon, gamma	11.0	Publications
5	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
6	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
7	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
8	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
9	IL10	interleukin 10	11.0	Publications
10	RBP3	retinol binding protein 3, interstitial	11.0	Publications
11	CD69	CD69 molecule	11.0	Publications
12	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
13	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
14	IL2RB	interleukin 2 receptor, beta	11.0	Publications
15	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
16	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
17	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
18	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
19	TLR4	toll-like receptor 4	11.0	Publications
20	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
21	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
22	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
23	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	11.0	Publications
24	HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	11.0	Publications
25	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
26	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
27	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.0	Publications
28	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
29	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
30	RCVRN	recoverin	11.0	Publications
31	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
32	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0	Publications
33	TNFRSF18	tumor necrosis factor receptor superfamily, member 18	11.0	Publications
34	KIR2DS4	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4	11.0	Publications
35	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
36	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	11.0	Publications
37	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
38	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
39	PMEL	premelanosome protein	11.0	Publications
40	CXCR5	chemokine (C-X-C motif) receptor 5	11.0	Publications
41	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
42	KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	11.0	Publications
43	CISH	cytokine inducible SH2-containing protein	11.0	Publications
44	KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	11.0	Publications
45	LCN2	lipocalin 2	11.0	Publications
46	IL9	interleukin 9	11.0	Publications
47	CXCL11	chemokine (C-X-C motif) ligand 11	11.0	Publications
48	CCR2	chemokine (C-C motif) receptor 2	11.0	Publications
49	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
50	IL17A	interleukin 17A	11.0	Publications

Pathways related to uveitis according to GeneDecks:

(show top 50)    (show all 143)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	SFTPD, IL1R1, TLR2
2	Immune System38	10.5	KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR2DS4, KIR3DL1
3	Natural killer cell mediated cytotoxicity20	10.5	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1
4	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	IL10, IL2, IL2RA, IL2RB, FASLG, FAS
5	THC Differentiation Pathway36	10.4	IL10, IL18, IL18R1, IL2, IL2RA, IL4
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	IL15, IL2, IL2RA, IL2RB, FASLG, CCL4
7	Autoimmune thyroid disease20	10.1	CD40LG, CD40, IL10, IL2, IL4, IL5
8	Asthma20	10.1	CD40LG, CD40, IL10, IL13, IL4, IL5
9	Jak-STAT signaling pathway20	10.1	CISH, IL10, IL13, IL15, IL19, IL2
10	Allograft rejection20	10.0	CD40LG, CD40, IL10, IL2, IL4, IL5
11	Antigen processing and presentation20	10.0	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1
12	Measles20	10.0	IL13, IL1A, IL1B, IL2, IL2RA, IL2RB
13	RAR-Gamma-RXR-Alpha Degradation36	9.9	IL15, IL19, IL2, IL20, IL22, IL23A
14	Transendothelial Migration of Leukocytes36	9.9	ITGA4, MMP3, IL8, AOC3, CCL4, CCR2
15	Malaria20	9.8	SELE, CD40LG, CD40, IL10, IL18, IL1B
16	Toxoplasmosis20	9.7	CD40LG, CD40, IL10, MAPK1, CCR5, IFNG
17	Chemokine signaling pathway20	9.6	IL8, MAPK1, CCL4, CCR2, CCL2, CCR4
18	Intestinal immune network for IgA production20	9.6	CD40LG, CD40, ITGA4, IL10, IL15, IL2
19	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.6	IL17A, IL1B, IL22, IL23A, IL4, IL6
20	Chemokine Signaling36	9.5	IL8, MAPK1, CCL4, CCR2, CCL2, CCR4
21	Toll-like receptor signaling pathway20	9.4	CD14, CD40, IL1B, IL6, IL8, MAPK1
22	Influenza A20	9.3	IVNS1ABP, IL18, IL1A, IL1B, IL6, IL8
23	Regulation of eIF4 and p70S6K36	9.2	CD4, ITGA4, IL13, IL15, IL18, IL19
24	Leishmaniasis20	9.2	ITGA4, IL10, IL1A, IL1B, IL4, MAPK1
25	Akt Signaling36	9.2	CD4, FGFR1, IL10, IL15, IL18, IL18R1
26	Cytokine Network36	9.2	IL10, IL13, IL15, IL18, IL1A, IL1B
27	Tuberculosis20	9.1	CD14, IL10, IL18, IL1A, IL1B, IL23A
28	NFAT Signaling and Lymphocyte Interactions36	8.9	BMP6, CD4, IL13, IL15, IL19, IL1A
29	Chagas disease (American trypanosomiasis)20	8.9	IL10, IL1B, IL2, IL6, IL8, FASLG
30	all-trans-Retinoic Acid Signaling in Brain36	8.9	BMP6, IL10, IL13, IL15, IL18, IL19
31	Rheumatoid arthritis20	8.8	VEGFA, MMP3, IL15, IL17A, IL18, IL1A
32	PAK Pathway36	8.6	BMP6, FGFR1, IL10, IL13, IL15, IL18
33	Tec Kinases Signaling36	8.6	BMP6, CD4, ITGA4, FGFR1, IL10, IL13
34	PGC1Alpha Pathway36	8.5	BMP6, CD4, IL13, IL15, IL18, IL19
35	SOCS Pathway36	8.5	BMP6, CISH, CD4, IL10, IL13, IL15
36	Cytokine-cytokine receptor interaction20	8.4	VEGFA, CD40LG, CD40, IL10, IL13, IL15
37	p38 Signaling36	8.1	BMP6, CD4, FGFR1, IL10, IL13, IL15
38	Endothelin-1 Signaling Pathway36	8.1	BMP6, IL10, IL13, IL18, IL19, IL1A
39	PEDF Induced Signaling36	8.0	SERPINF1, BMP6, IL10, IL13, IL15, IL18
40	MIF Mediated Glucocorticoid Regulation36	8.0	BMP6, CD14, MIF, IL10, IL13, IL15
41	MIF Regulation of Innate Immune Cells36	8.0	BMP6, CD14, MIF, IL10, IL13, IL15
42	Molecular Mechanisms of Cancer36	7.8	BMP6, CD4, ITGA4, FGFR1, IL13, IL15
43	ERK Signaling36	7.7	BMP6, ITGA4, IL10, IL13, IL18, IL19
44	Rho Family GTPases36	7.7	BMP6, ITGA4, FGFR1, IL10, IL13, IL15
45	STAT3 Pathway36	7.6	BMP6, CD4, IL10, IL13, IL15, IL18
46	Glucocorticoid Receptor Signaling36	7.6	BMP6, CD4, IL10, IL13, IL15, IL18
47	MAPK Family Pathway36	7.4	BMP6, CD4, FGFR1, IL10, IL13, IL15
48	TGF-Beta Pathway36	7.4	BMP6, CD4, FGFR1, IL10, IL13, IL15
49	Antioxidant Action of Vitamin-C36	7.3	BMP6, CD4, FGFR1, IL10, IL13, IL15
50	JAK-STAT Pathway36	7.1	BMP6, CD4, FGFR1, IL10, IL13, IL15

Compounds related to uveitis according to GeneDecks:

(show top 50)    (show all 460)

id	Compound	Score	Top Affiliating Genes
1	ivig32	11.0	SAG, IL18R1, FASLG, MBP, CCL4, CCR5
2	cyclophosphamide32 34 9 9	13.8	ITGA4, APOH, TRB@, CXCL9
3	leflunomide32 9 9	12.2	MMP3, IL13, IL15, IL18R1, IL1R1, IL1RN
4	peptidoglycan32	10.2	CD14, IL10, IL15, IL1B, IL1R1, IL1RN
5	rapamycin32 42	11.0	SELL, VEGFA, IL18R1, IL1R1, IL2, IL2RB
6	methacholine32 9 9	12.0	MPO, CD79A, CD14, ITGA4, IL13, IL17A
7	ribavirin32 34 9 9	13.0	CD40LG, IL10, IL18, IL2, IL4, CCR5
8	n acetylcysteine32	10.0	SELE, CD79A, CD40, MMP3, IL18, IL1R1
9	rituximab32 34 9 9	13.0	CD79A, CD40LG, CD40, IL10, IL13, IL15
10	cuprophan32	10.0	SELL, B2M, CD14, IL1B, IL1R1, IL1RN
11	mannose32	9.9	KIR2DL2, SFTPD, CD79A, CD69, CD14, CD4
12	polyacrylamide32	9.9	GC, SERPINA1, S100A8, CD14, MIF, IL1RN
13	gold sodium thiomalate32	9.9	SELE, CD14, IL1A, IL1B, IL1R1, IL1RN
14	mip 1alpha32	9.8	IL10, IL13, IL1B, IL4, IL6, IL8
15	toxin-132	9.7	IL10, IL1B, IL1RN, IL2, IL8, CCL4
16	etanercept32 9 9	11.5	MMP3, IL10, IL15, IL17A, IL18, IL18R1
17	groalpha32	9.4	SELE, IL10, IL13, IL17A, IL18, IL1A
18	atorvastatin32 34 9 18 9	13.4	SELE, SELL, VEGFA, BMP6, CD40LG, CD40
19	tarc32	9.3	CD4, ITGA4, IL10, IL13, IL18, IL1A
20	ccl432	9.3	IL13, IL15, IL17A, IL1R1, CCL4, CCL2
21	polyinosinic-polycytidylic acid32	9.2	SELE, CD40, IL10, IL15, IL18, IL2
22	vitamin a32 9 18 9	12.2	GC, RBP3, SERPINA1, LCN2, SAG, B2M
23	pentoxifylline32 9 9	11.1	SELL, BMP6, MPO, CD14, ITGA4, IL10
24	epinephrine32 9 18 9	12.0	SELE, SELL, BMP6, CD79A, CD69, IL1A
25	ibuprofen32 9 18 9	12.0	BMP6, MMP3, IL10, IL1B, IL1R1, IL1RN
26	anaphylatoxin32	8.9	MPO, IL1B, IL4, IL6, IL8, CCL2
27	5fluorouracil32	8.9	SELE, VEGFA, MPO, IL15, IL18, IL2
28	fluticasone propionate32 42 9 9	11.9	SELE, MPO, IL13, IL1B, IL4, IL5
29	mannitol32 9 9	10.6	XDH, B2M, CD40LG, GUSB, MDH2, IGHE
30	sb 20358032 42	9.6	SELE, VEGFA, BMP6, MMP3, FGFR1, IL13
31	gm-csf32	8.5	VEGFA, BMP6, CD14, IL10, IL13, IL15
32	h2o232	8.4	SELL, SERPINA1, XDH, MPO, CD79A, CD40
33	prednisolone32 9 9	10.2	SFTPD, SELL, BMP6, LCN2, MPO, CD79A
34	fmlp32	8.1	GC, SELL, LCN2, MPO, CD69, CD14
35	phosphatidylinositol32	8.0	SFTPD, BMP6, CISH, CD69, CD14, CD4
36	ly29400232	8.0	SELE, VEGFA, CD69, IL10, IL13, IL17A
37	cysteine32	8.0	KIR2DS4, SFTPD, RCVRN, SERPINF1, SERPINA1, LMOD1
38	diphenyleneiodonium32	7.8	SERPINF1, VEGFA, XDH, MPO, IL1B, IL1R1
39	prostacyclin32	7.8	SELE, VEGFA, BMP6, IL10, IL1A, IL1B
40	superoxide32 18	8.7	GC, SELL, LCN2, S100A8, XDH, MPO
41	pd 98,05932	7.6	BMP6, CD69, CD14, CD40, MMP3, FGFR1
42	herbimycin a32 42	8.1	SELE, SELL, BMP6, CD69, CD14, CD4
43	vegf32	6.8	SELE, SERPINF1, MPO, CD14, CD40LG, CD40
44	tyrosine32	6.6	KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KIR2DL5A, SELL
45	lactate32	6.1	SFTPD, SELE, SELL, BMP6, CKB, XDH
46	serine32	5.6	SFTPD, GC, SELE, SELL, SERPINF1, SERPINA1
47	testosterone32 9 18 9	INF	GC, SELE, B2M, CD79A, CD40LG, FGFR1
48	alanine32	INF	SELE, SELL, BMP6, CKB, SAG, S100A8
49	progesterone32 42 9 18 9	INF	CKB, FGFR1, IL6ST, CCL4, HSP90AA1, HSP90AB1
50	thymidine32 18	INF	SFTPD, SERPINA1, BMP6, B2M, CD69, CD40

Cellular components related to uveitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.7	HLA-DRB1, HLA-DQA1, HLA-C, HLA-B, HLA-A, ICAM1
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.3	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
3	ER to Golgi transport vesicle membrane	GO:012507	10.3	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
4	membrane raft	GO:045121	9.6	TLR4, TNFRSF1B, TNFRSF1A, TNF, FAS, CD4
5	cell surface	GO:009986	9.4	TNFRSF1A, NOD2, ELANE, TLR2, TGFB2, CX3CL1
6	external side of plasma membrane	GO:009897	9.2	ADA, CCR5, CCR4, FAS, FASLG, IL6ST
7	secretory granule	GO:030141	8.8	POMC, ELANE, HSPD1, IL1B, MPO, VEGFA
8	plasma membrane	GO:005886	8.0	CXCR1, CX3CL1, PRRT2, DPEP1, TLR4, TLR2
9	extracellular region	GO:005576	5.5	ALB, IL20, IL2, IL1R1, IL1B, IL1A
10	extracellular space	GO:005615	4.8	CX3CL1, CCL5, CCL18, CCL3, CCL11, CCL2

Biological processes related to uveitis according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MHC class II biosynthetic process	GO:045348	10.9	IFNG, TLR4, IL4, IL10, CD40LG
2	chemokine-mediated signaling pathway	GO:070098	10.9	CCR5, CCR4, CCL2, CCL5, CXCR3, CXCL12
3	positive regulation of interleukin-10 production	GO:032733	10.8	TLR4, NOD2, CD40LG, IL23A, HSPD1, IL4
4	cellular response to lipopolysaccharide	GO:071222	10.8	CCR5, NOS2, TNFRSF1B, ICAM1, IL10, CD14
5	negative regulation of growth of symbiont in host	GO:044130	10.8	TNF, IFNG, LTA, ELANE, TLR2, IL10
6	positive regulation of interleukin-12 production	GO:032735	10.7	TLR4, TLR2, IFNG, IL23A, CD40LG, CD40
7	regulation of immune response	GO:050776	10.7	KIR2DS2, KIR2DL1, KIR2DL3, KIR3DL1, CD40LG, CD40
8	positive regulation of cytokine secretion	GO:050715	10.7	IL1A, MIF, IL10, TNF, TLR2, CD14
9	interferon-gamma-mediated signaling pathway	GO:060333	10.7	HLA-A, IFNG, B2M, HLA-DPB1, HLA-DRB1, ICAM1
10	positive regulation of tumor necrosis factor production	GO:032760	10.7	CD14, CCL3, IL18, IL23A, IFNG, TNFRSF1A
11	B cell proliferation	GO:042100	10.7	CD40LG, HSPD1, IL10, CD40, CD79A
12	cell surface receptor signaling pathway	GO:007166	10.7	CXCR1, IL1R1, IL2RA, CCL2, SAG, CXCL10
13	macrophage chemotaxis	GO:048246	10.6	SFTPD, CCL2, CCL3, CX3CL1, CCL5
14	response to drug	GO:042493	10.5	B2M, IL10, IL1RN, TGFB2, IFNG, ICAM1
15	dendritic cell chemotaxis	GO:002407	10.4	CCR2, CCR5, CCL5, CXCR4, CXCR1
16	positive regulation of interleukin-6 production	GO:032755	10.4	TLR2, IL1A, TNF, IL1B, HSPD1, IL6
17	positive regulation of osteoclast differentiation	GO:045672	10.4	IFNG, IL17A, IL23A, CCL5, TNF
18	cellular response to tumor necrosis factor	GO:071356	10.4	GBA, ICAM1, IL18, IL8, CCL2, CCL3
19	response to glucocorticoid stimulus	GO:051384	10.4	ADM, TNF, IL10, SERPINF1, IL1RN, IL6
20	cellular response to interleukin-1	GO:071347	10.4	ICAM1, CCL5, CCL3, CCL2, IL8, IL17A
21	positive regulation of chemokine production	GO:032722	10.4	IL6, TLR4, TLR2, IL18, TNF
22	positive regulation of inflammatory response	GO:050729	10.3	IL23A, CCL3, IL18, IL2, IL15, CCR2
23	neutrophil chemotaxis	GO:030593	10.3	CCL2, TGFB2, IFNG, CCL3, IL8, IL1B
24	negative regulation of interleukin-6 production	GO:032715	10.2	TNF, GBA, TLR4, TNFRSF1A, IL10
25	response to lipopolysaccharide	GO:032496	10.2	LTA, TLR4, CXCL10, ADM, TNFRSF1A, FAS
26	calcium-mediated signaling	GO:019722	10.2	TNF, EIF2AK3, SELE, IL8, CXCR3, CCR5
27	lipopolysaccharide-mediated signaling pathway	GO:031663	10.2	IL1B, IL18, CCL2, CCL5, TNF, TLR4
28	positive regulation of interleukin-17 production	GO:032740	10.2	NOD2, IL15, IL18, IL2, IL23A
29	positive regulation of nitric oxide biosynthetic process	GO:045429	10.2	IL1B, HSP90AA1, IFNG, TLR2, TLR4, ICAM1
30	negative regulation of inflammatory response	GO:050728	10.1	ADA, ELANE, SERPINF1, GBA, IL2, TNFRSF1A
31	positive regulation of interferon-gamma production	GO:032729	10.1	TLR4, LTA, TNF, CD40LG, IL1B, HSPD1
32	cellular calcium ion homeostasis	GO:006874	10.1	CCL2, CCR2, CD40, CCL5, ELANE, CXCL12
33	positive regulation of T cell proliferation	GO:042102	10.1	IL6ST, CCL5, IFNG, IL6, IL4, IL1B
34	positive regulation of B cell proliferation	GO:030890	10.0	ADA, CD40LG, CD40, IL13, IL2, IL4
35	cytokine-mediated signaling pathway	GO:019221	10.0	CX3CL1, IL6, IL5, IL2RB, IL1B, IL1A
36	cellular response to organic cyclic compound	GO:071407	10.0	TNF, HSP90AB1, IL18, IL1B, CCL2, CCL3
37	aging	GO:007568	9.9	IL1B, ADA, SERPINF1, IL15, FAS, CCL5
38	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.9	CD40, TNF, CAT, IL1B, IL6, NOD2
39	chemotaxis	GO:006935	9.8	CCL11, CCR4, CCL2, CCR2, CCL4, MAPK1
40	cellular response to mechanical stimulus	GO:071260	9.7	IL1B, TLR4, FAS, IL18, IL13, CD40
41	positive regulation of angiogenesis	GO:045766	9.6	VEGFA, CCL5, CCL11, TNFRSF1A, CX3CL1, ADM
42	cell-cell signaling	GO:007267	9.4	ADM, POMC, CXCL9, CXCL6, CXCL11, CXCL10
43	innate immune response	GO:045087	9.4	TLR2, SFTPD, CD14, NOD2, CCR2, IFNA2
44	apoptotic process	GO:006915	9.2	CHIA, TNF, CD14, IL17A, IL19, IL1A
45	MAPK cascade	GO:000165	9.2	CCL5, TNF, CCR5, CCL2, MAPK1, IL18
46	negative regulation of apoptotic process	GO:043066	8.9	COL2A1, CAT, IL6, HSPD1, VEGFA, MIF
47	response to hypoxia	GO:001666	8.7	SERPINA1, NOS2, LTA, TLR4, TGFB2, CX3CL1
48	inflammatory response	GO:006954	8.6	CXCR4, CXCR1, CXCL9, CXCL6, CXCL2, CXCL11
49	signal transduction	GO:007165	8.1	RCVRN, FAS, MAPK1, FASLG, IL19, IL18R1
50	immune response	GO:006955	INF	TLR2, CCL4, MBP, FASLG, IL9, IL8

Molecular functions related to uveitis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine receptor activity	GO:004950	10.4	CXCR3, CXCR1, CCR5, CCR4, CCR2
2	chemokine activity	GO:008009	10.3	CXCL9, CCL2, CCL4, IL8, CCL11, CCL3
3	protease binding	GO:002020	10.1	ELANE, TNFRSF1A, TNF, MBP, IL1R1, SERPINA1
4	transmembrane signaling receptor activity	GO:004888	10.0	TLR4, TLR2, KLRD1, ICAM1, IL1R1, CD4
5	receptor binding	GO:005102	9.5	CX3CL1, CXCL1, CXCL10, CXCL12, POMC, ADM
6	heparin binding	GO:008201	9.2	ELANE, CCL5, CCL2, APOH, FGFR1, MPO
7	growth factor activity	GO:008083	8.6	CXCL12, CXCL1, TGFB2, IL9, IL6, IL5
8	cytokine activity	GO:005125	8.6	CXCL9, TGFB2, LTA, TNF, IFNG, IFNA2
9	protein binding	GO:005515	3.6	TNFRSF1B, TJP1, PTPN22, CTLA4, CRP, NOD2