MCID: UVT001
MIFTS: 58

Uveitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Uveitis

Aliases & Descriptions for Uveitis:

Name: Uveitis 12 29 52 42 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13141
ICD10 33 H20.9
MeSH 42 D014605
NCIt 47 C26909
UMLS 69 C0042164

Summaries for Uveitis

MalaCards based summary : Uveitis is related to choroiditis and chorioretinitis. An important gene associated with Uveitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluocinolone Acetonide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and retina, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia : 71 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 539)
id Related Disease Score Top Affiliating Genes
1 choroiditis 31.9 CCL2 IL10 TNF
2 chorioretinitis 31.4 CTLA4 IFNG IL10 TNF
3 mikulicz disease 31.1 IL1A IL4 TNF
4 tuberculosis 29.8 CCL2 IL10 IL17A IL4 TNF
5 hepatitis 29.6 CTLA4 HLA-B IFNG IL10 TNF
6 tularemia 29.4 IFNG IL10 IL4 TNF
7 central nervous system lymphoma 29.4 CCL2 HLA-B IL10 TNF
8 leptospirosis 29.4 IL17A NOD2 TNF
9 autoimmune retinopathy 29.3 ICAM1 IL17A IL2RA
10 malignant histiocytosis 29.3 IL1R1 NOD2 TNF
11 rheumatoid arthritis 28.5 CCL2 CTLA4 ICAM1 IFNG IL10 IL17A
12 intermediate uveitis 12.2
13 tubulointerstitial nephritis with uveitis 12.2
14 fuchs' heterochromic uveitis 12.2
15 posterior uveitis 12.0
16 anterior uveitis 12.0
17 phacoanaphylactic uveitis 11.9
18 infectious anterior uveitis 11.9
19 tuberculous uveitis 11.9
20 idiopathic anterior uveitis 11.9
21 infectious posterior uveitis 11.8
22 blau syndrome 11.8
23 infantile onset panniculitis with uveitis and systemic granulomatosis 11.8
24 idiopathic posterior uveitis 11.8
25 suppurative uveitis 11.8
26 pars planitis 11.7
27 sympathetic ophthalmia 11.6
28 panuveitis 11.3
29 birdshot chorioretinopathy 11.3
30 iridocyclitis 11.1
31 iritis 11.1
32 retinal vasculitis 11.0
33 acute posterior multifocal placoid pigment epitheliopathy 11.0
34 multifocal choroiditis 11.0
35 human t-cell leukemia virus type 1 11.0
36 vitreoretinopathy, neovascular inflammatory 10.9
37 behcet syndrome 10.8
38 sarcoidosis, early-onset 10.7
39 tropical spastic paraparesis 10.7
40 retrovirus-associated myelopathy 10.7
41 myelopathy, htlv-1-associated 10.7
42 uveoparotid fever 10.7
43 stickler syndrome, type i 10.7
44 orbital lymphoma 10.7
45 familial behcet-like autoinflammatory syndrome 10.7
46 hypersensitivity syndrome, carbamazepine-induced 10.7
47 short stature, developmental delay, and congenital heart defects 10.7
48 stickler syndrome, type ii 10.7
49 stickler syndrome, type iv 10.7
50 retinitis 10.4

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to Uveitis

Symptoms & Phenotypes for Uveitis

GenomeRNAi Phenotypes related to Uveitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.33 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.33 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.33 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.33 IL1R1 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.33 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.33 IL1R1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.33 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.33 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.33 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.33 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.33 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.33 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.33 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.33 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.33 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.33 IL1R1 IFNA2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.33 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.33 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.33 IFNA2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.33 IL1R1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.33 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.33 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.33 IL10 IL1R1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.33 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.33 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.33 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.33 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.33 IL10 IL1R1 IFNA2 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.33 IFNA2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.33 IL2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.33 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.33 IL2RA IL10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.33 IL2RA IL10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.33 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.33 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.33 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.33 IL1R1 IL2RA
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.33 IL1R1
39 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2
40 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2

MGI Mouse Phenotypes related to Uveitis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 CTLA4 CXCL10 CXCR3 ICAM1 IFNG IL10
2 hematopoietic system MP:0005397 10.33 IL1A IL1R1 IL2RA IL4 NOD2 TGFB2
3 immune system MP:0005387 10.31 CCL2 CTLA4 CXCL10 CXCR3 ICAM1 IFNG
4 cardiovascular system MP:0005385 10.22 ICAM1 CTLA4 CXCL10 CXCR3 IFNG IL10
5 mortality/aging MP:0010768 10.21 CTLA4 CXCL10 CXCR3 ICAM1 IFNG IL10
6 digestive/alimentary MP:0005381 10.19 CTLA4 ICAM1 IFNG IL10 IL17A IL2RA
7 endocrine/exocrine gland MP:0005379 10.18 IL2RA IL4 TGFB2 TNF CTLA4 ICAM1
8 craniofacial MP:0005382 10.05 IFNG IL10 IL17A IL1R1 IL4 TGFB2
9 nervous system MP:0003631 10 CXCL10 ICAM1 IFNG IL10 IL1R1 IL4
10 neoplasm MP:0002006 9.87 CXCR3 ICAM1 IFNG IL10 IL1A IL1R1
11 respiratory system MP:0005388 9.85 TNF IL17A IL1R1 IL2RA IL4 TGFB2
12 skeleton MP:0005390 9.61 IL17A IL1R1 IL4 NOD2 TGFB2 TNF
13 vision/eye MP:0005391 9.32 ICAM1 IFNG IL10 IL1R1 IL2RA IL4

Drugs & Therapeutics for Uveitis

Drugs for Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
3
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
4
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
7
Apraclonidine Approved Phase 4 66711-21-5 2216
8
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
9
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
10
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
11
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
12
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
13
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
14
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
15
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 90-82-4 7028
16
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
17
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
18
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
19
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
20
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
21
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
22
Adalimumab Approved Phase 4,Phase 2,Phase 3,Phase 1 331731-18-1 16219006
23
Chlorambucil Approved Phase 4 305-03-3 2708
24
Cyclophosphamide Approved, Investigational Phase 4,Phase 2 50-18-0, 6055-19-2 2907
25
Daclizumab Approved, Investigational Phase 4,Phase 2,Phase 1 152923-56-3
26
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
27
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
28
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
29
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
30
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
31
Travoprost Approved Phase 4 157283-68-6 5282226
32
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
33
Certolizumab pegol Approved Phase 4 428863-50-7
34
Nepafenac Approved Phase 4 78281-72-8 151075
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
37
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
38
Maleic acid Experimental Phase 4 110-16-7 444266
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
45 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
46 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
47 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
48 Dexamethasone 21-phosphate Phase 4,Phase 2,Phase 3,Phase 1
49 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
50 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 339)
id Name Status NCT ID Phase
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4
2 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4
3 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4
4 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4
5 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4
6 Multi Center Prospective Registry of Infliximab Use for Childhood Uveitis Completed NCT00589628 Phase 4
7 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
8 Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Completed NCT00543296 Phase 4
9 Corneal Specular Microscopy in Infectious and Noninfectious Uveitis Completed NCT00789984 Phase 4
10 TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema Completed NCT01870440 Phase 4
11 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4
12 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
13 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4
14 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
15 Steroids After Laser Trabeculoplasty for Glaucoma Completed NCT00981435 Phase 4
16 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4
17 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4
18 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
19 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4
20 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4
21 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Recruiting NCT03020992 Phase 4
22 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
23 PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial Recruiting NCT02374060 Phase 4
24 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Recruiting NCT01827722 Phase 4
25 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Recruiting NCT02684084 Phase 4
26 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Recruiting NCT02897115 Phase 4
27 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Not yet recruiting NCT02769702 Phase 4
28 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Not yet recruiting NCT03066869 Phase 4
29 Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema Not yet recruiting NCT02598869 Phase 4
30 Topical Treatment for Uveitic Macular Edema Not yet recruiting NCT01939691 Phase 4
31 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Not yet recruiting NCT03133767 Phase 4
32 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4
33 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4
34 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4
35 Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial) Unknown status NCT00348153 Phase 2, Phase 3
36 The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis Unknown status NCT00012506 Phase 3
37 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
38 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3
39 Oculusgen (Ologen) Glaucoma MMC Control in Estonia Unknown status NCT00524758 Phase 3
40 Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema Unknown status NCT01523314 Phase 2, Phase 3
41 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
42 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
43 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3
44 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3
45 Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis Completed NCT01385826 Phase 2, Phase 3
46 First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial Completed NCT01232920 Phase 3
47 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3
48 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3
49 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3
50 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: uveitis

Genetic Tests for Uveitis

Genetic tests related to Uveitis:

id Genetic test Affiliating Genes
1 Uveitis 29

Anatomical Context for Uveitis

MalaCards organs/tissues related to Uveitis:

39
Eye, T Cells, Retina, Testes, Endothelial, Skin, Bone Marrow

Publications for Uveitis

Articles related to Uveitis:

(show top 50) (show all 2186)
id Title Authors Year
1
Functional Conversion and Dominance of I^I' T Subset in Mouse Experimental Autoimmune Uveitis. ( 28069804 )
2017
2
A Prostacyclin Analog, Cicaprost, Exhibits Potent Anti-Inflammatory Activity in Human Primary Immune Cells and a Uveitis Model. ( 28072560 )
2017
3
Prevalence of Anti-infliximab Antibodies and Their Associated Co-factors in Children with Refractory Arthritis and/or Uveitis: A Retrospective Longitudinal Cohort Study. ( 28089968 )
2017
4
In response to: "Gautam N, Singh R, Agarwal A, et al. Pattern of Pediatric Uveitis at a Tertiary Referral Institute in North India". ( 28075200 )
2017
5
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
6
Retinal pigmentary changes in chronic uveitis mimicking retinitis pigmentosa. ( 28523457 )
2017
7
A comprehensive review of mTOR-inhibiting pharmacotherapy for the treatment of non-infectious uveitis. ( 28078989 )
2017
8
Uveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey. ( 28070763 )
2017
9
Cataract surgery in uveitis: a multicentre database study. ( 28043984 )
2017
10
Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis. ( 28091550 )
2017
11
Cutaneous Rosai-Dorfman disease associated with uveitis. ( 28073706 )
2017
12
Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases. ( 28070744 )
2017
13
Inhibiting Effect of Lithium Chloride on Endotoxin-induced Uveitis in Rats. ( 28081383 )
2017
14
Long-term Change of Subfoveal Choroidal Thickness in BehAset's Disease Patients with Posterior Uveitis. ( 28080153 )
2017
15
Bilateral posterior uveitis associated with Zika virus infection. ( 27939402 )
2017
16
Correction: Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis. ( 28069759 )
2017
17
Intraocular Inflammatory Mass Associated with Lens-Induce Uveitis. ( 28069494 )
2017
18
Rabbit hunter uveitis: case report of tularemia uveitis. ( 27585457 )
2016
19
Comparable Efficacy of Abatacept Used as First-line or Second-line Biological Agent for Severe Juvenile Idiopathic Arthritis-related Uveitis. ( 27633826 )
2016
20
High Efficacy of Methotrexate in Patients with Recurrent Idiopathic Acute Anterior Uveitis: a Prospective Study. ( 27170318 )
2016
21
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. ( 27989897 )
2016
22
Different roles of TNF inhibitors in acute anterior uveitis associated with ankylosing spondylitis: state of the art. ( 27686662 )
2016
23
A Rare Patient With Orbital Apex Syndrome, Anterior Uveitis, and Necrotizing Scleritis Due to Herpes Zoster Ophthalmicus. ( 28005810 )
2016
24
Intravitreal Dexamethasone Implant for the Treatment of Macular Edema in Chronic Non-infectious Uveitis. ( 27191685 )
2016
25
Analysis of the impact of allergy and atopy on new onset of uveitis. ( 27682154 )
2016
26
Specialty Practice and Cost Considerations in the Management of Uveitis Associated With Juvenile Idiopathic Arthritis. ( 27182746 )
2016
27
CFHR2-rs2986127 as a genetic protective marker for acute anterior uveitis in Chinese patients. ( 27306586 )
2016
28
Association of Low Vitamin D Levels With Noninfectious Anterior Uveitis. ( 28006052 )
2016
29
A cross-sectional study of submacular thickening in intermediate uveitis and determination of treatment threshold. ( 27188332 )
2016
30
Intravitreal Steroid Implants in the Management of Retinal Disease and Uveitis. ( 27575764 )
2016
31
Vision-Related Quality of Life in Patients with Inactive HLA-B27-Associated-Spectrum Anterior Uveitis. ( 26808922 )
2016
32
Presumed tuberculous uveitis in non-endemic country for tuberculosis: case series from a New Zealand tertiary uveitis clinic. ( 27896896 )
2016
33
New insights into the genetic component of non-infectious uveitis through an Immunochip strategy. ( 27609017 )
2016
34
Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats. ( 27170432 )
2016
35
Bilateral Anterior Uveitis Associated with Nivolumab Therapy. ( 27599197 )
2016
36
Recurrent Bilateral Anterior Uveitis with Kikuchi-Fujimoto Disease. ( 27420799 )
2016
37
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
38
A 10-year review of pediatric uveitis at a Hispanic-dominated tertiary pediatric ophthalmic clinic. ( 27601874 )
2016
39
Assessment of the Accuracy of Using ICD-9 Codes to Identify Uveitis, Herpes Zoster Ophthalmicus, Scleritis, and Episcleritis. ( 27387135 )
2016
40
SAFETY AND EFFICACY OF INTRAVITREAL DEXAMETHASONE IMPLANTS IN THE MANAGEMENT OF MACULAR EDEMA SECONDARY TO INFECTIOUS UVEITIS. ( 27183031 )
2016
41
Clinical Features and Complications of the HLA-B27-associated Acute Anterior Uveitis: A Metanalysis. ( 27404944 )
2016
42
Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )
2016
43
Hypopyon complicating the course of anterior uveitis in a patient with Behcet's syndrome. ( 27648274 )
2016
44
Chikungunya Virus Infection Manifesting as Intermediate Uveitis. ( 28010143 )
2016
45
S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis. ( 27786310 )
2016
46
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2016
47
TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS SYNDROME WITH A PRIMARY PRESENTATION OF ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY. ( 26967965 )
2016
48
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). ( 27196432 )
2016
49
Cytomegalovirus as a cause of hypertensive anterior uveitis in immunocompetent patients. ( 27613273 )
2016
50
Usefulness of anterior uveitis as an additional tool for diagnosing incomplete Kawasaki disease. ( 27186227 )
2016

Variations for Uveitis

Expression for Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for Uveitis

Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CCL2 CTLA4 CXCL10 HLA-B ICAM1 IFNA2
2
Show member pathways
13.93 CCL2 CXCL10 CXCR3 IL10 IL17A IL1A
3
Show member pathways
13.75 CCL2 CXCL10 CXCR3 IFNA2 IFNG IL10
4
Show member pathways
13.63 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
5
Show member pathways
13.51 CCL2 CXCL10 CXCR3 IL10 IL17A IL1A
6
Show member pathways
13.39 CCL2 CXCL10 CXCR3 IL10 IL17A IL1A
7
Show member pathways
13.32 CCL2 CXCL10 HLA-B ICAM1 IFNA2 IFNG
8
Show member pathways
13.04 CCL2 IFNA2 IL1A IL1R1 NOD2 TNF
9
Show member pathways
13.02 CCL2 CXCL10 IFNA2 IFNG IL10 TGFB2
10
Show member pathways
12.89 CCL2 CXCL10 HLA-B ICAM1 IFNA2 IFNG
11
Show member pathways
12.88 CTLA4 HLA-B ICAM1 IFNA2 IFNG IL10
12
Show member pathways
12.69 IFNG IL10 IL2RA IL4 TNF
13
Show member pathways
12.67 IFNG IL10 IL17A IL1A IL1R1 IL2RA
14
Show member pathways
12.65 CCL2 IFNG IL10 IL17A TNF
15
Show member pathways
12.64 HLA-B ICAM1 IFNA2 IFNG IL4 TNF
16 12.56 HLA-B ICAM1 IL1R1 IL2RA TGFB2 TNF
17
Show member pathways
12.56 CTLA4 IFNG IL10 IL17A IL1A IL4
18
Show member pathways
12.47 CCL2 CXCL10 IFNG IL17A IL4 TNF
19 12.45 CCL2 CTLA4 CXCL10 IFNG IL10 IL17A
20
Show member pathways
12.44 CCL2 ICAM1 IFNG IL4 TNF
21
Show member pathways
12.39 IFNG IL10 IL1A IL4 TGFB2 TNF
22
Show member pathways
12.35 CCL2 IL1A IL1R1 NOD2
23 12.35 HLA-B ICAM1 IFNG IL10
24 12.34 IFNA2 IFNG IL10 IL1A NOD2 TGFB2
25
Show member pathways
12.33 IFNA2 IFNG IL10 IL2RA IL4
26
Show member pathways
12.32 IFNG IL1A IL1R1 TNF
27
Show member pathways
12.31 CXCL10 IFNG IL1R1 IL4 TNF
28
Show member pathways
12.27 HLA-B IFNA2 IFNG IL10 IL17A IL1A
29 12.23 CCL2 ICAM1 IFNG IL1A IL1R1 TNF
30 12.18 IFNG IL1A IL1R1 TGFB2 TNF
31 12.14 IFNA2 IFNG IL10 IL2RA IL4 TNF
32 12.12 CCL2 ICAM1 IL10 IL17A IL1A IL4
33 12.1 CCL2 CXCL10 ICAM1 NOD2 TNF
34
Show member pathways
12.07 IFNG IL1R1 IL2RA IL4
35
Show member pathways
12.07 IFNG IL17A IL1R1 IL4 TGFB2
36 12.05 CCL2 ICAM1 IL1A TGFB2 TNF
37
Show member pathways
12.04 IFNG IL10 IL17A TNF
38 12.04 IL1A IL1R1 IL2RA IL4 TNF
39 12.03 IFNG IL10 IL1R1 TGFB2 TNF
40 12 CCL2 CXCL10 ICAM1 IFNG IL1A IL1R1
41
Show member pathways
11.91 CTLA4 IFNG IL2RA IL4 TNF
42 11.88 IFNA2 IFNG IL10 TNF
43 11.87 CTLA4 ICAM1 IL10 IL2RA IL4 TGFB2
44 11.84 IFNG TGFB2 TNF
45 11.83 ICAM1 IFNG IL4
46 11.82 IFNA2 IFNG IL10 IL2RA
47 11.8 IL10 IL1A TNF
48
Show member pathways
11.79 ICAM1 IFNG IL1A TNF
49 11.71 CCL2 IL4 TNF
50 11.71 CCL2 CTLA4 ICAM1 IFNG IL17A IL1A

GO Terms for Uveitis

Cellular components related to Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 CCL2 CXCL10 IFNA2 IFNG IL10 IL17A
2 cell surface GO:0009986 9.8 CXCR3 HLA-B ICAM1 IL1R1 IL2RA NOD2
3 extracellular space GO:0005615 9.73 CCL2 CXCL10 ICAM1 IFNA2 IFNG IL10
4 external side of plasma membrane GO:0009897 9.28 CTLA4 CXCL10 CXCR3 ICAM1 IFNG IL17A

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.99 CCL2 CXCL10 ICAM1 IL10
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL2 ICAM1 NOD2 TNF
3 negative regulation of gene expression GO:0010629 9.98 IFNA2 IFNG TGFB2 TNF
4 chemotaxis GO:0006935 9.96 CCL2 CXCL10 CXCR3 IL4
5 cytokine-mediated signaling pathway GO:0019221 9.95 CCL2 IFNA2 IL1A IL1R1
6 defense response GO:0006952 9.93 CXCL10 IFNA2 NOD2 TNF
7 response to drug GO:0042493 9.91 CCL2 ICAM1 IFNG IL10 IL4 TGFB2
8 cellular response to interleukin-1 GO:0071347 9.9 CCL2 ICAM1 IL17A
9 cellular response to organic cyclic compound GO:0071407 9.9 CCL2 NOD2 TNF
10 response to glucocorticoid GO:0051384 9.89 CCL2 IL10 TNF
11 chemokine-mediated signaling pathway GO:0070098 9.89 CCL2 CXCL10 CXCR3
12 regulation of inflammatory response GO:0050727 9.89 IL1R1 IL4 NOD2
13 interferon-gamma-mediated signaling pathway GO:0060333 9.88 HLA-B ICAM1 IFNG
14 B cell differentiation GO:0030183 9.88 IFNA2 IL10 IL4
15 neutrophil chemotaxis GO:0030593 9.88 CCL2 IFNG TGFB2
16 positive regulation of T cell proliferation GO:0042102 9.87 IFNG IL2RA IL4
17 positive regulation of cell adhesion GO:0045785 9.85 CCL2 IFNG TNF
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNA2 IFNG IL4
19 positive regulation of tumor necrosis factor production GO:0032760 9.84 CCL2 IFNG NOD2
20 positive regulation of interleukin-6 production GO:0032755 9.82 IL1A NOD2 TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 ICAM1 IFNG TNF
22 extrinsic apoptotic signaling pathway GO:0097191 9.81 IFNG TGFB2 TNF
23 negative regulation of T cell proliferation GO:0042130 9.78 CTLA4 IL10 IL2RA
24 cell surface receptor signaling pathway GO:0007166 9.76 CCL2 CXCL10 CXCR3 IFNA2 IFNG IL1R1
25 glial cell migration GO:0008347 9.73 CCL2 TGFB2
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 IL10 TNF
27 positive regulation of cytokine secretion GO:0050715 9.73 IL10 IL1A TNF
28 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL10 ICAM1 IFNG IL10 TNF
29 positive regulation of isotype switching to IgG isotypes GO:0048304 9.72 IFNG IL4
30 T cell chemotaxis GO:0010818 9.72 CXCL10 CXCR3
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 IL17A NOD2
32 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 ICAM1 IL10 IL4
33 humoral immune response GO:0006959 9.71 CCL2 IFNA2 IFNG TNF
34 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
35 positive regulation of osteoclast differentiation GO:0045672 9.69 IFNG IL17A TNF
36 positive regulation of cellular extravasation GO:0002693 9.68 CCL2 ICAM1
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
38 type 2 immune response GO:0042092 9.67 IL10 IL4
39 defense response to protozoan GO:0042832 9.67 IFNG IL10 IL4
40 positive regulation of interleukin-23 production GO:0032747 9.65 IFNG IL17A
41 negative regulation of growth of symbiont in host GO:0044130 9.65 IFNG IL10 TNF
42 positive regulation of neutrophil extravasation GO:2000391 9.63 IL1A IL1R1
43 negative regulation of immune response GO:0050777 9.63 CTLA4 IL2RA TGFB2
44 regulation of isotype switching GO:0045191 9.62 IL10 IL4
45 positive regulation of mononuclear cell migration GO:0071677 9.62 IL4 TNF
46 inflammatory response GO:0006954 9.61 CCL2 CXCL10 CXCR3 IFNA2 IL10 IL17A
47 receptor biosynthetic process GO:0032800 9.6 IL10 TNF
48 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.59 ICAM1 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
50 regulation of complement-dependent cytotoxicity GO:1903659 9.58 IL10 TGFB2

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL2 CXCL10 IFNA2 IFNG IL10 IL17A

Sources for Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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