MCID: VCC001
MIFTS: 47

Vaccinia malady

Summaries for Vaccinia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, located in skin, has material basis in vaccinia virus, which is used as a live vaccine against smallpox. the virus is transmitted by contact with the vaccination site before it has healed, or transmitted by fomites that have been contaminated with live virus from the vaccination site. the infection has symptom rash, has symptom fever, and has symptom body aches.

MalaCards: Vaccinia is related to smallpox and cowpox, and has symptoms including rash, fever and body aches. An important gene associated with Vaccinia is VRK1 (vaccinia related kinase 1), and among its related pathways are Signal transduction Erk Interactions: Inhibition of Erk and MAP Kinase Signaling. The compound cl 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and whole blood.

Wikipedia:64 Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It... more...

Aliases & Classifications for Vaccinia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

vaccinia 8 10 61


External Ids:

Disease Ontology8 DOID:3298
SNOMED-CT57 111852003
MeSH35 D014615

Related Diseases for Vaccinia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vaccinia:



Diseases related to vaccinia

Clinical Features for Vaccinia

Sources:
8Disease Ontology
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Symptoms:

8
  • rash
  • fever
  • body aches

Drugs & Therapeutics for Vaccinia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Vaccinia

Drug clinical trials:

Search ClinicalTrials for Vaccinia

Search NIH Clinical Center for Vaccinia

Search CenterWatch for Vaccinia

Genetic Tests for Vaccinia

Anatomical Context for Vaccinia

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Vaccinia:

33
Skin, Whole blood, Brain, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Adrenal gland, Breast, Ovary, Prostate, Cervix, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial

FMA organs/tissues related to Vaccinia:

14
Skin

Animal Models for Vaccinia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Vaccinia

Sources:
51PubMed
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Articles related to Vaccinia:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide symporter. (24383569)
2014
2
Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses. (23874722)
2013
3
Inactivation of vaccinia virus by natural sunlight and by artificial UVB radiation. (22816993)
2013
4
Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. (23248307)
2013
5
Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence. (23761407)
2013
6
Limited Effectiveness of Psoralen- and Ultraviolet-Inactivated Vaccinia Virus on SHIV Infection. (24130561)
2013
7
Primary human leukocyte subsets differentially express vaccinia virus receptors enriched in lipid rafts. (23785200)
2013
8
CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans. (23667112)
2013
9
Inhibitors of C5 complement enhance vaccinia virus oncolysis. (23661042)
2013
10
A mechanism for induction of a hypoxic response by vaccinia virus. (23836663)
2013
11
Biogenesis of the vaccinia virus membrane: genetic and ultrastructural analysis of the contributions of the A14 and A17 proteins. (23135725)
2013
12
Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma. (23221568)
2013
13
Vaccinia virus A19 protein participates in the transformation of spherical immature particles to barrel-shaped infectious virions. (23885081)
2013
14
Evaluation of normalization strategies for qPCR quantitation of intracellular viral DNA: the example of Vaccinia virus. (22981457)
2012
15
Mutagenesis of the palmitoylation site in vaccinia virus envelope glycoprotein B5. (22238237)
2012
16
Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status. (22286752)
2012
17
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody. (23091626)
2012
18
Incorporation of the B18R gene of vaccinia virus into an oncolytic herpes simplex virus improves antitumor activity. (22692498)
2012
19
Emergence and reemergence of vaccinia-like viruses: global scenario and perspectives. (23729995)
2012
20
Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: the prospect of using existing vaccines to stem the AIDS pandemic. (21851326)
2012
21
Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread. (23006741)
2012
22
Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice. (22419805)
2012
23
A small molecule screen in yeast identifies inhibitors targeting protein-protein interactions within the vaccinia virus replication complex. (22884885)
2012
24
A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. (22031940)
2012
25
Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus. (21267444)
2011
26
Immunization with recombinant DNA and modified vaccinia virus Ankara (MVA) vectors delivering PSCA and STEAP1 antigens inhibits prostate cancer progression. (21182993)
2011
27
Stability of vaccinia-vectored recombinant oral rabies vaccine under field conditions: a 3-year study. (22468025)
2011
28
MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. (21386827)
2011
29
Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents. (21844323)
2011
30
Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. (21569797)
2011
31
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. (21915095)
2011
32
Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model. (20719991)
2010
33
Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha. (19846675)
2010
34
Insertion of vaccinia virus C7L host range gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens. (20613977)
2010
35
Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus. (17141855)
2007
36
Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. (17014939)
2006
37
Vaccinia virus activation of CCR5 invokes tyrosine phosphorylation signaling events that support virus replication. (16809330)
2006
38
Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence. (15386406)
2005
39
Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. (15613691)
2005
40
Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin. (15364449)
2004
41
Regulation of interleukin 12 and interleukin 10 expression in vaccinia virus-infected human monocytes and U-937 cell line. (10880234)
2000
42
Redirected cellular cytotoxicity by infection of effector cells with a recombinant vaccinia virus encoding a tumor-specific monoclonal antibody. (10811480)
2000
43
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. (10077623)
1999
44
Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis. (10337913)
1999
45
Gene transfer into human dendritic antigen-presenting cells by vaccinia virus and adenovirus vectors. (9917089)
1998
46
Induction of varicella-zoster virus-neutralizing antibodies in mice by co-infection with recombinant vaccinia viruses expressing the gH or gL gene. (8627224)
1996
47
Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells. (8552643)
1996
48
Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia viruses. (7673167)
1995
49
Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses. (212474)
1978
50
Smallpox vaccinia with late interstitial keratitis; a case report. (13478034)
1957

Genetic Variations for Vaccinia

Expression for genes affiliated with Vaccinia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vaccinia

Search GEO for disease gene expression data for Vaccinia.

Pathways for genes affiliated with Vaccinia

Sources:
12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG, 54Reactome
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Compounds for genes affiliated with Vaccinia

Sources:
45Novoseek
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Compounds related to Vaccinia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cl 1004510.8DUSP4, DUSP1, DUSP3

GO Terms for genes affiliated with Vaccinia

Sources:
16Gene Ontology
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Biological processes related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inactivation of MAPK activityGO:00018811.0DUSP4, DUSP1, DUSP3, DUSP8
2protein dephosphorylationGO:00647010.9DUSP4, DUSP1, DUSP8, DUSP15
3endoderm formationGO:00170610.7DUSP1, DUSP4
4response to coldGO:00940910.7VGF, RBM3
5negative regulation of ERK1 and ERK2 cascadeGO:07037310.6VRK3, DUSP3
6protein autophosphorylationGO:04677710.5VRK2, VRK1, EIF2AK2

Molecular functions related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase tyrosine/serine/threonine phosphatase activityGO:01701710.8DUSP4, DUSP1, DUSP8
2protein tyrosine phosphatase activityGO:00472510.8DUSP15, DUSP8, DUSP3, DUSP4
3protein tyrosine/serine/threonine phosphatase activityGO:00813810.7DUSP3, DUSP15
4protein tyrosine/threonine phosphatase activityGO:00833010.4DUSP4, DUSP1

Products for genes affiliated with Vaccinia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vaccinia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet