MCID: VCC001
MIFTS: 48

Vaccinia malady

Summaries for Vaccinia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, located in skin, has material basis in vaccinia virus, which is used as a live vaccine against smallpox. the virus is transmitted by contact with the vaccination site before it has healed, or transmitted by fomites that have been contaminated with live virus from the vaccination site. the infection has symptom rash, has symptom fever, and has symptom body aches.

MalaCards: Vaccinia is related to breast cancer and ovarian cancer, and has symptoms including body aches, fever and rash. An important gene associated with Vaccinia is VRK1 (vaccinia related kinase 1), and among its related pathways are Signal transduction Erk Interactions: Inhibition of Erk and MAP Kinase Signaling. The compound cl 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Wikipedia:63 Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It... more...

Aliases & Classifications for Vaccinia

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

vaccinia 8 10 60


External Ids:

Disease Ontology8 DOID:3298
SNOMED-CT56 111852003
MeSH34 D014615

Related Diseases for Vaccinia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vaccinia:



Diseases related to vaccinia

Clinical Features for Vaccinia

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8Disease Ontology
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Symptoms:

8
  • body aches
  • fever
  • rash

Drugs & Therapeutics for Vaccinia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vaccinia

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Anatomical Context for Vaccinia

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Vaccinia:

32
Skin, T cells, Breast, Monocytes, Prostate, Nk cells, Testes, Liver, Colon, Endothelial, Brain, Lung, Ovary, Cervix, B cells, Salivary gland, Thyroid, Kidney, Bone, Eye

FMA organs/tissues related to Vaccinia:

14
Skin

Animal Models for Vaccinia or affiliated genes

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Publications for Vaccinia

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50PubMed
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Articles related to Vaccinia:

(show top 50)    (show all 878)
idTitleAuthorsYear
1
Environmental persistence of vaccinia virus on materials. (23815079)
2013
2
Immunotherapy: Oncolytic vaccinia virus shows promise in liver cancer. (23438758)
2013
3
IL-18 Expression Results in a Recombinant Vaccinia Virus That Is Highly Attenuated and Immunogenic. (24168450)
2013
4
Genomic analysis of vaccinia virus strain TianTan provides new insights into the evolution and evolutionary relationships between Orthopoxviruses. (23608359)
2013
5
Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase. (24316823)
2013
6
Optical detection and virotherapy of live metastatic tumor cells in body fluids with vaccinia strains. (24019862)
2013
7
Characterization of ectromelia virus deficient in EVM036, the homolog of vaccinia virus F13L, and its application for rapid generation of recombinant viruses. (23035222)
2012
8
Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM. (22731659)
2012
9
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. (22966084)
2012
10
Vaccinia viruses isolated from skin infection in horses produced cutaneous and systemic disease in experimentally infected rabbits. (22244689)
2012
11
A novel high-throughput vaccinia virus neutralization assay and preexisting immunity in populations from different geographic regions in China. (22438922)
2012
12
Measurement of antibody responses to Modified Vaccinia virus Ankara (MVA) and Dryvax(Ar) using proteome microarrays and development of recombinant protein ELISAs. (22100890)
2012
13
Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus. (22490469)
2012
14
Adjuvant-like effect of vaccinia virus 14K protein: a case study with malaria vaccine based on the circumsporozoite protein. (22615208)
2012
15
A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB. (20980497)
2011
16
Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated. (21183678)
2011
17
The host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virus. (21543482)
2011
18
VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone. (21055490)
2011
19
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. (21467219)
2011
20
Zoonotic Brazilian Vaccinia virus: from field to therapy. (21896287)
2011
21
Vaccinia virus infection after sexual contact with a military smallpox vaccinee -Washington, 2010. (20592687)
2010
22
Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects. (20816902)
2010
23
Intradermal delivery of recombinant vaccinia virus vector DIs induces gut-mucosal immunity. (20618768)
2010
24
A pandemic influenza H1N1 live vaccine based on modified vaccinia Ankara is highly immunogenic and protects mice in active and passive immunizations. (20808939)
2010
25
Aptamers recognizing glycosylated hemagglutinin expressed on the surface of vaccinia virus-infected cells. (20873781)
2010
26
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. (18615110)
2009
27
The orthopoxvirus 68-kilodalton ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in nonpermissive human and murine cells. (19357172)
2009
28
Downregulation of vaccinia virus intermediate and late promoters by host transcription factor YY1. (19297611)
2009
29
Comparative efficacy of modified vaccinia Ankara (MVA) as a potential replacement smallpox vaccine. (16950548)
2007
30
Detailed kinetics of immune responses to a new cell culture-derived smallpox vaccine in vaccinia-naA^ve adults. (17597266)
2007
31
Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. (16137803)
2006
32
Predicted function of the vaccinia virus G5R protein. (17021162)
2006
33
Analysis of cases reported as generalized vaccinia during the US military smallpox vaccination program, December 2002 to December 2004. (16781288)
2006
34
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant. (16156900)
2005
35
The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection. (16061267)
2005
36
Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy. (16227216)
2005
37
Kinetic analysis of the interactions between vaccinia virus complement control protein and human complement proteins C3b and C4b. (15308738)
2004
38
Members of a novel family of mammalian protein kinases complement the DNA-negative phenotype of a vaccinia virus ts mutant defective in the B1 kinase. (14747564)
2004
39
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). (15378002)
2004
40
Kinetic properties of p53 phosphorylation by the human vaccinia- related kinase 1. (11883897)
2002
41
Induction of protective host immunity to carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic mice, by immunizing with a recombinant vaccinia-CEA virus. (9973217)
1999
42
The cytoplasmic and transmembrane domains of the vaccinia virus B5R protein target a chimeric human immunodeficiency virus type 1 glycoprotein to the outer envelope of nascent vaccinia virions. (9060681)
1997
43
The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory protein. (9123854)
1997
44
Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. (1924358)
1991
45
Cross-neutralizing antibodies in rabbits immunized with HIV-1 gp160 purified from simian cells infected with a recombinant vaccinia virus. (1742074)
1991
46
Characterization of a molluscum contagiosum virus homolog of the vaccinia virus p37K major envelope antigen. (2041084)
1991
47
The existence of an envelope on extracellular cowpox virus and its antigenic relationship to the vaccinia envelope. (3729722)
1986
48
Comparative studies on LS antigens induced by vaccinia and cowpox viruses. (94351)
1979
49
Differentiation of variola, monkeypox, and vaccinia antisera by radioimmunoassay. (201390)
1977
50
LABORATORY DIAGNOSIS OF SMALLPOX AND SIMILAR VIRAL DISEASES BY MEANS OF TISSUE CULTURE METHODS. II. DIFFERENTIATION OF SMALLPOX VIRUS FROM VARICELLA, VACCINIA, COWPOX AND HERPES VIRUSES. (14127272)
1964

Genetic Variations for Vaccinia

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Expression for genes affiliated with Vaccinia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vaccinia

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Pathways for genes affiliated with Vaccinia

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12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Vaccinia

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44Novoseek
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Compounds related to Vaccinia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cl 1004410.8DUSP4, DUSP1, DUSP3

GO Terms for genes affiliated with Vaccinia

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16Gene Ontology
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Biological processes related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inactivation of MAPK activityGO:00018811.0DUSP4, DUSP1, DUSP3, DUSP8
2protein dephosphorylationGO:00647010.9DUSP4, DUSP1, DUSP8, DUSP15
3endoderm formationGO:00170610.7DUSP1, DUSP4
4response to coldGO:00940910.7VGF, RBM3
5negative regulation of ERK1 and ERK2 cascadeGO:07037310.6VRK3, DUSP3
6protein autophosphorylationGO:04677710.5VRK2, VRK1, EIF2AK2

Molecular functions related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase tyrosine/serine/threonine phosphatase activityGO:01701710.8DUSP4, DUSP1, DUSP8
2protein tyrosine phosphatase activityGO:00472510.8DUSP15, DUSP8, DUSP3, DUSP4
3protein tyrosine/serine/threonine phosphatase activityGO:00813810.7DUSP3, DUSP15
4protein tyrosine/threonine phosphatase activityGO:00833010.4DUSP4, DUSP1

Products for genes affiliated with Vaccinia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vaccinia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet