MCID: VCC001
MIFTS: 49

Vaccinia malady

Infectious diseases, Skin diseases categories
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Summaries for Vaccinia

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Disease Ontology:8 A viral infectious disease that results in infection, located in skin, has material basis in vaccinia virus, which is used as a live vaccine against smallpox. the virus is transmitted by contact with the vaccination site before it has healed, or transmitted by fomites that have been contaminated with live virus from the vaccination site. the infection has symptom rash, has symptom fever, and has symptom body aches.

MalaCards based summary: Vaccinia is related to smallpox and cowpox, and has symptoms including An important gene associated with Vaccinia is VRK1 (vaccinia related kinase 1), and among its related pathways are Phosphatases and Regulation of p38-alpha and p38-beta. The compounds cl 100 and Water have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Wikipedia:65 Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It... more...

Aliases & Classifications for Vaccinia

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Vaccinia, Aliases & Descriptions:

Name: Vaccinia 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:3298
SNOMED-CT57 111852003
MeSH34 D014615

Related Diseases for Vaccinia

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Graphical network of the top 20 diseases related to Vaccinia:



Diseases related to vaccinia

Symptoms for Vaccinia

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Drugs & Therapeutics for Vaccinia

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Drug clinical trials:

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Search NIH Clinical Center for Vaccinia

Genetic Tests for Vaccinia

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Anatomical Context for Vaccinia

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MalaCards organs/tissues related to Vaccinia:

32
Skin, T cells, Breast, Prostate, Monocytes, Nk cells, Testes, Colon, Liver, Endothelial, Brain, Lung, Ovary, Eye, Bone, Kidney, Thyroid, Salivary gland, Cervix, B cells, Neutrophil

FMA organs/tissues related to Vaccinia:

14
Skin

Animal Models for Vaccinia or affiliated genes

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Publications for Vaccinia

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Articles related to Vaccinia:

(show top 50)    (show all 892)
idTitleAuthorsYear
1
MyD88-Dependent Immunity to a Natural Model of Vaccinia Virus Infection Does Not Involve Toll-Like Receptor 2. (24403581)
2014
2
A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism. (25351724)
2014
3
Environmental persistence of vaccinia virus on materials. (23815079)
2013
4
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
5
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility. (24062339)
2013
6
Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro. (23207068)
2013
7
Immunogenicity and safety of the vaccinia virus LC16m8I9 vector expressing SIV Gag under a strong or moderate promoter in a recombinant BCG prime-recombinant vaccinia virus boost protocol. (23731631)
2013
8
Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation. (24333835)
2013
9
Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. (22623782)
2012
10
Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. (23236521)
2012
11
Optimisation of prime-boost immunization in mice using novel protein-based and recombinant vaccinia (Tiantan)-based HBV vaccine. (22970140)
2012
12
Sequence-divergent chordopoxvirus homologs of the o3 protein maintain functional interactions with components of the vaccinia virus entry-fusion complex. (22114343)
2012
13
Oral vaccination with vaccinia virus expressing the tick antigen subolesin inhibits tick feeding and transmission of Borrelia burgdorferi. (22864146)
2012
14
Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo. (22761378)
2012
15
Human and animal infections by vaccinia-like viruses in the state of Rio de Janeiro: a novel expanding zoonosis. (22185829)
2011
16
Preferential replication of vaccinia virus in the ovaries is independent of immune regulation through IL-10 and TGF-I^. (21958373)
2011
17
Vaccinia virus infections in martial arts gym, Maryland, USA, 2008. (21470473)
2011
18
Sensitivity to ultraviolet radiation of Lassa, vaccinia, and Ebola viruses dried on surfaces. (21104283)
2011
19
A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB. (20980497)
2011
20
Proteome analysis of vaccinia virus IHD-W-infected HEK 293 cells with 2-dimensional gel electrophoresis and MALDI-PSD-TOF MS of on solid phase support N-terminally sulfonated peptides. (21806805)
2011
21
Correlations between vaccinia-specific immune responses within a cohort of armed forces members. (21958369)
2011
22
Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus. (21267444)
2011
23
Animal movement and establishment of vaccinia virus Cantagalo strain in Amazon biome, Brazil. (21470472)
2011
24
Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68. (21779374)
2011
25
Enhancement of immune response to an antigen delivered by vaccinia virus by displaying the antigen on the surface of intracellular mature virion. (21664218)
2011
26
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. (21283510)
2010
27
Introduction of the six major genomic deletions of modified vaccinia virus Ankara (MVA) into the parental vaccinia virus is not sufficient to reproduce an MVA-like phenotype in cell culture and in mice. (20668072)
2010
28
Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate. (21085591)
2010
29
Functional F11L and K1L genes in modified vaccinia virus Ankara restore virus-induced cell motility but not growth in human and murine cells. (20627347)
2010
30
The neutralizing antibody response to the vaccinia virus A28 protein is specifically enhanced by its association with the H2 protein. (20673745)
2010
31
Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis. (20628573)
2010
32
PI3K signaling regulates rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells. (19211763)
2009
33
Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons. (19656868)
2009
34
Vaccinia virus G8R protein: a structural ortholog of proliferating cell nuclear antigen (PCNA). (19421403)
2009
35
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. (18615110)
2009
36
A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis. (18550675)
2008
37
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. (18927075)
2008
38
Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. (18037545)
2007
39
Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. (16139395)
2006
40
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. (17062162)
2006
41
Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus). (16275078)
2006
42
Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (14645249)
2004
43
Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (15207627)
2004
44
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
45
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine- 18 within the mdm-2 binding site of the p53 tumour suppressor protein. (10951572)
2000
46
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. (10077623)
1999
47
The genome of cowpox virus contains a gene related to those encoding the epidermal growth factor, transforming growth factor alpha and vaccinia growth factor. (10403701)
1999
48
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. (9394784)
1997
49
Induction of varicella-zoster virus-neutralizing antibodies in mice by co-infection with recombinant vaccinia viruses expressing the gH or gL gene. (8627224)
1996
50
Expression of Rab GTPases using recombinant vaccinia viruses. (8583918)
1995

Variations for Vaccinia

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Expression for genes affiliated with Vaccinia

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Expression patterns in normal tissues for genes affiliated with Vaccinia

Search GEO for disease gene expression data for Vaccinia.

Pathways for genes affiliated with Vaccinia

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Pathways related to Vaccinia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9DUSP3, DUSP1
29.8DUSP1, DUSP8
39.8DUSP1, DUSP8
4
Show member pathways
9.7BANF1, VRK2, VRK1
5
Show member pathways
9.7VRK1, VRK2, BANF1
6
Show member pathways
9.7VRK1, VRK2, BANF1
7
Show member pathways
9.6VRK3, DUSP3, DUSP1
89.6VRK3, DUSP3, DUSP1
9
Show member pathways
MAPK signaling pathway37
9.6DUSP8, DUSP1, DUSP3

Compounds for genes affiliated with Vaccinia

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Sources:
44Novoseek, 24HMDB
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Compounds related to Vaccinia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cl 100449.6DUSP1, DUSP3
2Water249.3DUSP3, DUSP15, DUSP1, DUSP8
3Phosphate249.2DUSP3, DUSP15, DUSP1, DUSP8

GO Terms for genes affiliated with Vaccinia

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Biological processes related to Vaccinia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic nuclear envelope reassemblyGO:00708410.1BANF1, VRK1
2negative regulation of MAPK cascadeGO:0434099.9DUSP3, DUSP1
3negative regulation of ERK1 and ERK2 cascadeGO:0703739.9VRK3, DUSP3
4inactivation of MAPK activityGO:0001889.7DUSP3, DUSP1, DUSP8
5mitotic nuclear envelope disassemblyGO:0070779.7BANF1, VRK1
6peptidyl-tyrosine dephosphorylationGO:0353359.7DUSP3, DUSP1, DUSP8
7protein dephosphorylationGO:0064709.6DUSP8, DUSP1, DUSP15
8response to cAMPGO:0515919.6DUSP1, VGF

Molecular functions related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine/serine/threonine phosphatase activityGO:0081389.7DUSP15, DUSP3
2protein tyrosine phosphatase activityGO:0047259.7DUSP3, DUSP15, DUSP8
3MAP kinase tyrosine/serine/threonine phosphatase activityGO:0170179.7DUSP1, DUSP8
4protein bindingGO:0055157.7DUSP1, DUSP15, FAM21C, VRK1, VRK2, RAB9A

Products for genes affiliated with Vaccinia

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  • Antibodies
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Sources for Vaccinia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet