MCID: VCC001
MIFTS: 48

Vaccinia malady

Summaries for Vaccinia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, located in skin, has material basis in vaccinia virus, which is used as a live vaccine against smallpox. the virus is transmitted by contact with the vaccination site before it has healed, or transmitted by fomites that have been contaminated with live virus from the vaccination site. the infection has symptom rash, has symptom fever, and has symptom body aches.

MalaCards: Vaccinia is related to breast cancer and ovarian cancer, and has symptoms including body aches, fever and rash. An important gene associated with Vaccinia is VRK1 (vaccinia related kinase 1), and among its related pathways are Signal transduction Erk Interactions: Inhibition of Erk and MAP Kinase Signaling. The compound cl 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Wikipedia:63 Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It... more...

Aliases & Classifications for Vaccinia

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

vaccinia 8 10 60


External Ids:

Disease Ontology8 DOID:3298
SNOMED-CT56 111852003
MeSH34 D014615

Related Diseases for Vaccinia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vaccinia:



Diseases related to vaccinia

Clinical Features for Vaccinia

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8Disease Ontology
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Symptoms:

8
  • body aches
  • fever
  • rash

Drugs & Therapeutics for Vaccinia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Vaccinia

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Genetic Tests for Vaccinia

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Anatomical Context for Vaccinia

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Vaccinia:

32
Skin, T cells, Breast, Monocytes, Prostate, Nk cells, Testes, Liver, Colon, Endothelial, Brain, Lung, Ovary, Cervix, B cells, Salivary gland, Thyroid, Kidney, Bone, Eye

FMA organs/tissues related to Vaccinia:

14
Skin

Animal Models for Vaccinia or affiliated genes

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Publications for Vaccinia

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50PubMed
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Articles related to Vaccinia:

(show top 50)    (show all 878)
idTitleAuthorsYear
1
Analysis of viral membranes formed in cells infected by a vaccinia virus L2-deletion mutant suggests their origin from the endoplasmic reticulum. (23192873)
2013
2
Mucosal priming with a replicating-vaccinia virus-based vaccine elicits protective immunity to simian immunodeficiency virus challenge in rhesus monkeys. (23487457)
2013
3
Protective effect of surfactant protein d in pulmonary vaccinia virus infection: implication of A27 viral protein. (23518578)
2013
4
Vaccinia virus GLV-1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer. (23506710)
2013
5
Role of the vaccinia virus O3 protein in cell entry can be fulfilled by its Sequence flexible transmembrane domain. (23816434)
2013
6
Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival. (23800258)
2013
7
Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies. (23891003)
2013
8
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
9
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity. (22532670)
2012
10
The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors. (22013032)
2012
11
Treating tumors with a vaccinia virus expressing IFNI^ illustrates the complex relationships between oncolytic ability and immunogenicity. (22008913)
2012
12
A pilot study comparing the development of EIAV Env-specific antibodies induced by DNA/recombinant vaccinia-vectored vaccines and an attenuated Chinese EIAV vaccine. (23171359)
2012
13
Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients. (22454499)
2012
14
Sensitivity to ultraviolet radiation of Lassa, vaccinia, and Ebola viruses dried on surfaces. (21104283)
2011
15
Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus-infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs. (21715493)
2011
16
Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1. (20739958)
2011
17
Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure. (21391303)
2011
18
Lung surfactant DPPG phospholipid inhibits vaccinia virus infection. (21095206)
2011
19
Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses. (21935396)
2011
20
Susceptibility of Vaccinia virus to chemical disinfectants. (21734141)
2011
21
A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization. (22324207)
2011
22
Modulation of anxiety behavior by intranasally administered vaccinia virus complement control protein and curcumin in a mouse model of Alzheimer's disease. (21143157)
2011
23
Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice. (21989183)
2011
24
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis. (21354589)
2011
25
Detection of vaccinia virus DNA by quartz crystal microbalance. (21820997)
2011
26
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. (20802145)
2010
27
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase. (19631609)
2009
28
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. (18266467)
2008
29
A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost. (17098336)
2007
30
Antibody responses to vaccinia membrane proteins after smallpox vaccination. (17570109)
2007
31
Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. (17938195)
2007
32
Vaccinia virus impairs directional migration and chemokine receptor switch of human dendritic cells. (17357104)
2007
33
Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity. (16595141)
2006
34
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. (16439990)
2006
35
Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes. (14515148)
2003
36
Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. (12481437)
2002
37
The genome of cowpox virus contains a gene related to those encoding the epidermal growth factor, transforming growth factor alpha and vaccinia growth factor. (10403701)
1999
38
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. (9394784)
1997
39
Characterization of two vaccinia CD36 recombinant-virus-generated monoclonal antibodies (10/5, 13/10): effects on malarial cytoadherence and platelet functions. (9030758)
1997
40
Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. (7609027)
1995
41
Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells. (7624318)
1995
42
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function. (8236283)
1993
43
Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate. (1458480)
1992
44
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. (1339315)
1992
45
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins. (1501279)
1992
46
Communicating hydrocephalus in newborn hamsters and cats following vaccinia virus infection. (7241186)
1981
47
A comparison of the antigens present on the surface of virus released artificially from chick cells infected with vaccinia virus, and cowpox virus and its white pock mutant. (4624399)
1972
48
Serological relationship of buffalopox virus to vaccinia and cowpox viruses. (4394186)
1970
49
The inhibition of growth of vaccinia and cowpox viruses in RK 13 cells. (4974738)
1968
50
PROTECTION OF RHESUS MONKEYS AGAINST MONKEYPOX BY VACCINIA VIRUS IMMUNIZATION. (14103224)
1964

Genetic Variations for Vaccinia

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Expression for genes affiliated with Vaccinia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vaccinia

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Pathways for genes affiliated with Vaccinia

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12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Vaccinia

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44Novoseek
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Compounds related to Vaccinia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cl 1004410.8DUSP4, DUSP1, DUSP3

GO Terms for genes affiliated with Vaccinia

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16Gene Ontology
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Biological processes related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inactivation of MAPK activityGO:00018811.0DUSP4, DUSP1, DUSP3, DUSP8
2protein dephosphorylationGO:00647010.9DUSP4, DUSP1, DUSP8, DUSP15
3endoderm formationGO:00170610.7DUSP1, DUSP4
4response to coldGO:00940910.7VGF, RBM3
5negative regulation of ERK1 and ERK2 cascadeGO:07037310.6VRK3, DUSP3
6protein autophosphorylationGO:04677710.5VRK2, VRK1, EIF2AK2

Molecular functions related to Vaccinia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase tyrosine/serine/threonine phosphatase activityGO:01701710.8DUSP4, DUSP1, DUSP8
2protein tyrosine phosphatase activityGO:00472510.8DUSP15, DUSP8, DUSP3, DUSP4
3protein tyrosine/serine/threonine phosphatase activityGO:00813810.7DUSP3, DUSP15
4protein tyrosine/threonine phosphatase activityGO:00833010.4DUSP4, DUSP1

Products for genes affiliated with Vaccinia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vaccinia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet