MCID: VGN019
MIFTS: 34

Vaginal Discharge

Categories: Reproductive diseases

Aliases & Classifications for Vaginal Discharge

MalaCards integrated aliases for Vaginal Discharge:

Name: Vaginal Discharge 12 41 14

Classifications:



External Ids:

Disease Ontology 12 DOID:3767
MeSH 41 D019522
NCIt 46 C50795
UMLS 69 C0227791

Summaries for Vaginal Discharge

MalaCards based summary : Vaginal Discharge is related to endometritis and vaginitis. An important gene associated with Vaginal Discharge is DSPP (Dentin Sialophosphoprotein). The drugs Metronidazole and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include testes, cervix and skin.

Wikipedia : 72 Vaginal discharge is a mixture of liquid, cells, and bacteria that lubricates and protects the vagina.... more...

Related Diseases for Vaginal Discharge

Diseases related to Vaginal Discharge via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 endometritis 30.1 HP PGF
2 vaginitis 11.7
3 bacterial vaginosis 11.6
4 pelvic inflammatory disease 11.5
5 trichomoniasis 11.4
6 chlamydia 11.4
7 leukorrhea 11.3
8 fallopian tube carcinoma 11.0
9 fitz-hugh-curtis syndrome 11.0
10 neuroretinitis 10.2 EXTL3 FLNA
11 cervicitis 10.2
12 shoulder impingement syndrome 10.1 FLNA PGF
13 skeletal tuberculosis 10.0 FLNA HP
14 retinitis pigmentosa, y-linked 10.0 GYPC HPSE2
15 urethritis 10.0
16 endometrial disease 10.0 DSPP HP PGF
17 episodic pain syndrome, familial, 1 9.9
18 candidiasis 9.9
19 vulvovaginitis 9.9
20 hereditary elliptocytosis 9.9 GYPC SPTB
21 aging 9.9
22 congenital hemolytic anemia 9.8 HP SPTB
23 vaginal disease 9.7 DSPP EXTL3 FLNA SPTB
24 blood group, i system 9.7
25 breast cancer 9.7
26 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.7
27 klippel-trenaunay-weber syndrome 9.7
28 pemphigus vulgaris, familial 9.7
29 schistosoma mansoni infection, susceptibility/ 9.7
30 renal hypodysplasia/aplasia 1 9.7
31 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 9.7
32 adenomyosis 9.7
33 urinary tract infections, recurrent 9.7
34 cervical cancer 9.7
35 lymphangioleiomyomatosis 9.7
36 mycobacterium tuberculosis 1 9.7
37 human immunodeficiency virus type 1 9.7
38 alpha-fetoprotein deficiency 9.7
39 hydrops, lactic acidosis, and sideroblastic anemia 9.7
40 pemphigus vulgaris 9.7
41 sacrococcygeal teratoma 9.7
42 ulcerative colitis 9.7
43 colitis 9.7
44 keratomalacia 9.7
45 leiomyoma 9.7
46 schistosomiasis 9.7
47 lymphangioma 9.7
48 ectropion 9.7
49 cystitis 9.7
50 papilloma 9.7

Graphical network of the top 20 diseases related to Vaginal Discharge:



Diseases related to Vaginal Discharge

Symptoms & Phenotypes for Vaginal Discharge

Drugs & Therapeutics for Vaginal Discharge

Drugs for Vaginal Discharge (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2 50-28-2 5757
3
Loperamide Approved Phase 4 53179-11-6 3955
4
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
5
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3 55-56-1 2713 9552079
6
Iodine Approved, Investigational Phase 4,Phase 3 7553-56-2 807
7
Povidone Approved Phase 4,Phase 3 9003-39-8
8
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
9 Anti-Infective Agents Phase 4,Phase 2,Phase 3
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
12 Anti-Bacterial Agents Phase 4,Phase 3
13 Antidiarrheals Phase 4
14 Calcium polycarbophil Phase 4
15 Calcium, Dietary Phase 4
16 Carbopol 940 Phase 4
17 Cathartics Phase 4
18 Contraceptive Agents Phase 4,Phase 2
19 Estradiol 17 beta-cypionate Phase 4,Phase 2
20 Estradiol 3-benzoate Phase 4,Phase 2
21 Estradiol valerate Phase 4,Phase 2 979-32-8
22 Estrogens Phase 4,Phase 2
23 Gastrointestinal Agents Phase 4
24 Hormone Antagonists Phase 4,Phase 3,Phase 2
25 Hormones Phase 4,Phase 3,Phase 2
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
27 Laxatives Phase 4
28 Polyestradiol phosphate Phase 4,Phase 2
29 Anti-Infective Agents, Local Phase 4,Phase 3
30 Blood Substitutes Phase 4,Phase 3
31 cadexomer iodine Phase 4,Phase 3
32 Chlorhexidine gluconate Phase 4,Phase 3
33 Dermatologic Agents Phase 4,Phase 3
34 Disinfectants Phase 4,Phase 3
35 Micronutrients Phase 4,Phase 3
36 Pharmaceutical Solutions Phase 4,Phase 3
37 Plasma Substitutes Phase 4,Phase 3
38 Trace Elements Phase 4,Phase 3
39 Psyllium Nutraceutical Phase 4
40
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
41
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
42
Secnidazole Approved Phase 3 3366-95-8
43
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
44
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
45
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
46
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
47
Nystatin Approved, Vet_approved Phase 3 1400-61-9 11953884
48
Ethanol Approved Phase 3 64-17-5 702
49 Antifungal Agents Phase 3
50 Cytochrome P-450 CYP2C9 Inhibitors Phase 3

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 The Vaginal Health Trial Completed NCT02516202 Phase 4 Vagifem;Replens
2 Examining the Impact of Tampon Use on the Vaginal Microbiota Completed NCT03346759 Phase 4
3 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
4 Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution Recruiting NCT03305159 Phase 4 Povidone-Iodine;4% Chlorhexidine Gluconate
5 The Efficacy of Tachosil® for Prevention of Hemorrhage After Loop Electrosurgical Excisional Procedure (LEEP) Active, not recruiting NCT02629510 Phase 4 Tachosil
6 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
7 Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge Completed NCT02111629 Phase 3 Fluconazole and Secnidazole
8 Study of the Management of Vaginal Discharge in West African Using Single Dose Treatments Completed NCT00313131 Phase 3 tinidazole+fluconazole vs metronidazole+clotrimazole
9 The Value of Bacterial Loads by Real Time PCR in Predicting Recurrence of Abnormal Vaginal Flora After Oral Metronidazole Therapy Completed NCT01287728 Phase 3 Treatment BY METROMIDAZOLE
10 Efficacy and Safety of Clino-san on Vaginal Dryness of Breast Cancer Patients Completed NCT00607295 Phase 3 clino-san vaginal lubricant
11 Diabetes Mellitus and Vulvovaginal Candidiasis Completed NCT00353561 Phase 3 Boric;Fluconazole
12 A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment o Completed NCT02210689 Phase 3 clindamycin phosphate vaginal cream 2%
13 Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis Completed NCT02515656 Phase 3 POLYGYNAX®;GYNODAKTARIN®;Placebo
14 A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections Terminated NCT00528008 Phase 3
15 Efficacy and Safety of the Association of Clotrimazole and Metronidazole in the Treatment of Vaginal Discharge From Different Etiologies. Withdrawn NCT02713139 Phase 3 Clotrimazole + Metronidazole;Metronidazole;Clotrimazole
16 Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infection Completed NCT00305227 Phase 2 Lactin-V;Placebo
17 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2 Metronidazole
18 Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis Completed NCT01055106 Phase 2 GW05;GW05;GW05;Metronidazole
19 Tactile Electrosurgical Ablation in Cases of Dysfunctional Uterine Bleeding Completed NCT02248194 Phase 2
20 Vaginal Creams to Reduce Vaginal Erosion in Pessary Users Withdrawn NCT02316249 Phase 2 Estradiol
21 The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis Unknown status NCT02733731 Phase 1 Chinese Herbal Compound Ointment;Estriol
22 The Presence of Microbes in the Sperm and Their Impact on Sperm Capacitation and IVF Treatment Unknown status NCT02585297
23 Conservative Management of Symptomatic Pelvic Organ Prolapse Using Vaginal Pessaries: Generation of a Standardized Management Protocol Unknown status NCT02113969
24 Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue Completed NCT01347632 Metronidazole
25 Validity of Patient-Collected Wet Mounts Completed NCT02641717
26 Postpartum Dyspareunia Resulting From Vaginal Atrophy Completed NCT01319968 Estriol 0.1% vaginal cream
27 A Validation Study of Genzyme Diagnostics OSOM Trichomonas Rapid Test and BVBlue Test Completed NCT00682851
28 VS-Sense Result Reading Clarity Completed NCT00803127
29 Effects of Father-Neonate Skin-to-Skin Contact on Attachment Completed NCT02886767
30 Vaginal and Oral Microbiome Crosstalk Recruiting NCT02898818
31 Specimen Collection Study for Development and Validation of Laboratory Procedures Recruiting NCT01236027
32 A Randomized Controlled Trial of Permanent vs Absorbable Suture for Uterosacral Ligament Suspension Recruiting NCT02888093
33 Timing of Pessary Care Recruiting NCT02371083
34 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820
35 Apical Suspension Repair for Vault Prolapse In a Three-Arm Randomized Trial Design Recruiting NCT02676973
36 Women's Improvement of Sexual Health (WISH) Demonstration Project Active, not recruiting NCT03045809
37 Diagnosing Bacterial Vaginosis/Vaginitis (BV) Using the Gynecologene Test Method Enrolling by invitation NCT02558179
38 Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific Biomarkers in Vaginal Fluids Withdrawn NCT02704650
39 Vulvar Contact Dermatitis Resulting From Urine Incontinence Withdrawn NCT01320046

Search NIH Clinical Center for Vaginal Discharge

Cochrane evidence based reviews: vaginal discharge

Genetic Tests for Vaginal Discharge

Anatomical Context for Vaginal Discharge

MalaCards organs/tissues related to Vaginal Discharge:

38
Testes, Cervix, Skin, Uterus, Kidney

Publications for Vaginal Discharge

Articles related to Vaginal Discharge:

(show top 50) (show all 332)
# Title Authors Year
1
Response of lactating dairy cows with or without purulent vaginal discharge to gonadotropin-releasing hormone and prostaglandin F2I+. ( 29385599 )
2018
2
Trichomonas vaginalis is very rare among women with vaginal discharge in Podlaskie province, Poland. ( 28612378 )
2017
3
Effectiveness of intrauterine treatment with cephapirin in dairy cows with purulent vaginal discharge. ( 28043367 )
2017
4
Effects of intrauterine infusion of Escherichia coli lipopolysaccharide on uterine health, resolution of purulent vaginal discharge, and reproductive performance of lactating dairy cows. ( 28434752 )
2017
5
Effects of intrauterine infusion of Escherichia coli lipopolysaccharide on uterine mRNA gene expression and peripheral polymorphonuclear leukocytes in Jersey cows diagnosed with purulent vaginal discharge. ( 28434729 )
2017
6
Cervical cytopathological changes among women with vaginal discharge attending teaching hospital. ( 28469316 )
2017
7
Consider the Risk of Vesicouterine Fistula in the Event of Intermittent Fluid Vaginal Discharge after a Cesarean Section. ( 29090213 )
2017
8
Application of a bacteriological on-farm test to reduce antimicrobial usage in dairy cows with purulent vaginal discharge. ( 28237589 )
2017
9
Effect of Vaginal Hygiene Module to Attitudes and Behavior of Pathological Vaginal Discharge Prevention Among Female Adolescents in Slemanregency, Yogyakarta, Indonesia. ( 29282418 )
2017
10
Primary chylous vaginal discharge demonstrated with noncontrast magnetic resonance lymphography. ( 28475249 )
2017
11
Epidemiology and clinico-investigative study of organisms causing vaginal discharge. ( 28442807 )
2017
12
Vaginal discharge concentrations of I^-human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes. ( 29197087 )
2017
13
Syndromic management of sexually transmissible infections in resource-poor settings: a systematic review with meta-analysis of the abnormal vaginal discharge flowchart for Neisseria gonorrhoea and Chlamydia trachomatis. ( 28838352 )
2017
14
Genetic and functional analysis of the bovine uterine microbiota. Part II: Purulent vaginal discharge versus healthy cows. ( 28259411 )
2017
15
Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F2I+ treatment. ( 28318582 )
2017
16
Efficacy of Tamarindus indicus, Melia azadirach and Santalum album in syndromic management of abnormal vaginal discharge: A single-blind randomised controlled trial. ( 29257757 )
2017
17
Effect of diagnosis and treatment of clinical endometritis based on vaginal discharge score grading system in postpartum Holstein cows. ( 28740032 )
2017
18
An Insight to How Estate Women in Sri Lanka Manage Abnormal Vaginal Discharge. ( 28451566 )
2017
19
Definitive Management of Persistent Vaginal Discharge Caused by Leiomyoma-endometrial Fistulas after Uterine Artery Embolization. ( 29223699 )
2017
20
Sacrococcygeal teratoma presenting with vaginal discharge and polyp in an infant. ( 29269272 )
2017
21
High Risk Human Papilloma Virus Genotypes in Kurdistan Region in Patients with Vaginal Discharge. ( 27509950 )
2016
22
Do female patients with nonpathological vaginal discharge need the same evaluation as for Dhat syndrome in males? ( 26985107 )
2016
23
Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. ( 27843660 )
2016
24
Study to Evaluate Targeted Management and Syndromic Management in Women Presenting with Abnormal Vaginal Discharge. ( 27651658 )
2016
25
The Performance of the Vaginal Discharge Syndromic Management in Treating Vaginal and Cervical Infection: A Systematic Review and Meta-Analysis. ( 27706174 )
2016
26
Prepubertal vaginal discharge: Vaginoscopy to rule out foreign body. ( 27976557 )
2016
27
Utility of Laboratory Diagnosis for Confirmation of the Syndromic Case Management in Married Indian Women with Vaginal Discharge. ( 27833516 )
2016
28
Sore throat A^ vaginal discharge A^ labial ulcer A^ Dx? ( 27474821 )
2016
29
Co-infection with Bovine Herpesvirus 4 and Histophilus somni Significantly Extends the Service Period in Dairy Cattle with Purulent Vaginal Discharge. ( 26690881 )
2016
30
Variables associated with vaginal discharge after ultrasound-guided percutaneous microwave ablation for adenomyosis. ( 27087631 )
2016
31
Efficacy of syndromic management measured as symptomatic improvement in females with vaginal discharge syndrome. ( 27190409 )
2016
32
Primary care management of women with persistent vaginal discharge. ( 27861272 )
2016
33
Profuse Vaginal Discharge May Equally Suggest Adenoma Malignum and Lobular Endocervical Glandular Hyperplasia (LEGH), But Same Cover, Different Story. ( 27678817 )
2015
34
Menstrual hygiene practices and its association with reproductive tract infections and abnormal vaginal discharge among women in India. ( 26614609 )
2015
35
Diagnostic Value of Vaginal Discharge, Wet Mount and Vaginal pH - An Update on the Basics of Gynecologic Infectiology. ( 26028693 )
2015
36
Technical note: Intraobserver, interobserver, and test-retest reliabilities of an assessment of vaginal discharge from cows with and without acute puerperal metritis. ( 26026759 )
2015
37
A 78-Year-Old Woman with Fecaloid Vaginal Discharge. ( 26495410 )
2015
38
A rare case of foreign body causing recurrent vaginal discharge in prepubertal child. ( 25738041 )
2015
39
Randomized clinical trial of intrauterine cephapirin infusion in dairy cows for the treatment of purulent vaginal discharge and cytological endometritis. ( 26210270 )
2015
40
Uterine Natural Killer Cell and Human Leukocyte Antigen-G1 and Human Leukocyte Antigen-G5 Expression in Vaginal Discharge of Threatened-Abortion Women: A Case-Control Study. ( 26509178 )
2015
41
Alpha-fetoprotein as a tool to distinguish amniotic fluid from urine, vaginal discharge, and semen. ( 25569004 )
2015
42
Determination of optimal diagnostic criteria for purulent vaginal discharge and cytological endometritis in dairy cows. ( 26210278 )
2015
43
Effect of intrauterine dextrose on reproductive performance of lactating dairy cows diagnosed with purulent vaginal discharge under certified organic management. ( 25828665 )
2015
44
Chronic vaginal discharge due to vesicovaginal fistula. ( 25876713 )
2015
45
Utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. ( 25954668 )
2015
46
Chylocolporrhea or chylous vaginal discharge: diagnostic conundrum with therapeutic challenge. ( 26386963 )
2015
47
Diagnosis of acute puerperal metritis by electronic nose device analysis of vaginal discharge in dairy cows. ( 24746098 )
2014
48
Evaluation of vaginal discharge with the Metricheck device and the relationship to reproductive performance in postpartum dairy cows. ( 24961582 )
2014
49
Sexually transmitted infections in women: A correlation of clinical and laboratory diagnosis in cases of vaginal discharge syndrome. ( 25506555 )
2014
50
A 3-year-old girl with a recent history of yellow-green vaginal discharge. ( 24605856 )
2014

Variations for Vaginal Discharge

Expression for Vaginal Discharge

Search GEO for disease gene expression data for Vaginal Discharge.

Pathways for Vaginal Discharge

GO Terms for Vaginal Discharge

Cellular components related to Vaginal Discharge according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cortical cytoskeleton GO:0030863 8.62 FLNA GYPC

Sources for Vaginal Discharge

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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