Aliases & Classifications for Vaginal Disease

MalaCards integrated aliases for Vaginal Disease:

Name: Vaginal Disease 12 14
Vaginal Diseases 40 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:121
MeSH 41 D014623
NCIt 46 C26910
UMLS 69 C0042251

Summaries for Vaginal Disease

MedlinePlus : 40 Vaginal problems are some of the most common reasons women go to the doctor. They may have symptoms such as Itching Burning Pain Abnormal bleeding Discharge One common problem is vaginitis, an inflammation of the vagina. Other problems that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. Treatment of vaginal problems depends on the cause.

MalaCards based summary : Vaginal Disease, also known as vaginal diseases, is related to cervicitis and vaginitis, and has symptoms including pelvic pain and leukorrhea. An important gene associated with Vaginal Disease is EZR (Ezrin), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Immune response IFN alpha/beta signaling pathway. The drugs Acetylcysteine and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and uterus, and related phenotype is immune system.

Wikipedia : 72 A vaginal disease is a pathological condition that affects part or all of the... more...

Related Diseases for Vaginal Disease

Diseases related to Vaginal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 cervicitis 29.5 CD79A DEFB4A FLNA
2 vaginitis 29.1 CXCL8 EZR IL1B IL6 PRF1 SERPINH1
3 systemic onset juvenile idiopathic arthritis 10.5 IL1B PRF1
4 peptic esophagitis 10.5 CXCL8 IL1B
5 periodontitis, chronic 10.5 IL1B IL6
6 acute transverse myelitis 10.5 CXCL8 IL6
7 streptococcal toxic-shock syndrome 10.5 CXCL8 IL6
8 haemophilus influenzae 10.5 CXCL8 IL1B
9 opisthorchiasis 10.5 CXCL8 IL1B
10 uremic pruritus 10.4 IL1B IL6
11 denture stomatitis 10.4 CXCL8 IL6
12 euthyroid sick syndrome 10.4 IL1B IL6
13 laryngitis 10.4 IL1B IL6
14 papillary conjunctivitis 10.4 CXCL8 IL6
15 cervical incompetence 10.4 IL6 SERPINH1
16 cardiac rupture 10.4 CXCL8 PRF1
17 ascaris lumbricoides infection 10.4 IL1B IL6
18 crohn's colitis 10.4 CXCL8 IL1B
19 acute vascular insufficiency of intestine 10.4 IL1B IL6
20 poems syndrome 10.4 IL1B IL6
21 acute monoblastic leukemia 10.4 CXCL8 IL6
22 recurrent corneal erosion 10.4 CXCL8 IL1B IL6
23 bagassosis 10.4 CXCL8 IL1B IL6
24 viral encephalitis 10.3 CXCL8 IL1B IL6
25 acute respiratory distress syndrome 10.3 CXCL8 IL1B IL6
26 prostatitis 10.3 CXCL8 IL1B IL6
27 leptospirosis 10.3 CXCL8 IL1B IL6
28 pyelonephritis 10.3 CXCL8 IL1B IL6
29 appendicitis 10.3 CXCL8 IL1B IL6
30 aggressive periodontitis 10.3 CXCL8 IL1B IL6
31 chorioamnionitis 10.3 CXCL8 IL1B IL6
32 pneumoconiosis 10.3 CXCL8 IL1B IL6
33 bacterial meningitis 10.3 CXCL8 IL1B IL6
34 esophagitis 10.3 CXCL8 IL1B IL6
35 gastroenteritis 10.3 CXCL8 IL1B IL6
36 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 CXCL8 IL1B IL6
37 osteomyelitis 10.3 CXCL8 IL1B IL6
38 contact dermatitis 10.3 CXCL8 IL1B IL6
39 toxic shock syndrome 10.3 CXCL8 IL1B IL6
40 chronic fatigue syndrome 10.3 CXCL8 IL1B IL6
41 peritonitis 10.3 CXCL8 IL1B IL6
42 monocytic leukemia 10.3 CXCL8 IL1B IL6
43 trypanosomiasis 10.3 CXCL8 IL1B IL6
44 synovitis 10.3 CXCL8 IL1B IL6
45 meningitis 10.3 CXCL8 IL1B IL6
46 capillary leak syndrome 10.3 CXCL8 IL6
47 periodontitis 10.3 CXCL8 IL1B IL6
48 chagas disease 10.3 CXCL8 IL1B IL6
49 interstitial lung disease 10.3 CXCL8 IL1B IL6
50 exudative glomerulonephritis 10.3 CD79A CXCL8

Graphical network of the top 20 diseases related to Vaginal Disease:



Diseases related to Vaginal Disease

Symptoms & Phenotypes for Vaginal Disease

UMLS symptoms related to Vaginal Disease:


pelvic pain, leukorrhea

MGI Mouse Phenotypes related to Vaginal Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 PRF1 SLPI SPTB CD79A EZR FLNA

Drugs & Therapeutics for Vaginal Disease

Drugs for Vaginal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 316)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 443-48-1 4173
3
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 18323-44-9 29029
4
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
6
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3 57-63-6 5991
7
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
8
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 19387-91-8 5479
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
10
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
11
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
12
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
13
Azithromycin Approved Phase 4,Phase 2,Phase 3 83905-01-5 53477736 447043 55185
14
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
15
Desflurane Approved Phase 4 57041-67-5 42113
16
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
17
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
18
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
19
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
20
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 23593-75-1 2812
21
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
22
Dequalinium Approved, Investigational Phase 4,Phase 3 6707-58-0
23
Terconazole Approved Phase 4,Phase 3,Early Phase 1 67915-31-5 441383
24
Loperamide Approved Phase 4 53179-11-6 3955
25
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
26
Ephedrine Approved Phase 4,Phase 2,Phase 3 299-42-3 9294
27
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3 90-82-4 7028
28
Norethindrone Approved Phase 4 68-22-4 6230
29 Cranberry Approved, Investigational, Nutraceutical Phase 4
30 Apricot Approved, Nutraceutical Phase 4
31 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
33 Antidotes Phase 4
34 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Antioxidants Phase 4
36 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
37 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
38 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
39 Expectorants Phase 4
40 N-monoacetylcystine Phase 4
41 Protective Agents Phase 4,Phase 2
42 Respiratory System Agents Phase 4,Phase 2,Phase 3
43 Clindamycin palmitate Phase 4,Phase 3,Phase 2,Early Phase 1
44 Clindamycin phosphate Phase 4,Phase 3,Phase 2,Early Phase 1
45 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Contraceptives, Oral Phase 4,Phase 2,Phase 3
47 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1
48 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1
49 Estradiol valerate Phase 4,Phase 3,Phase 2,Phase 1 979-32-8
50 Estrogens Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 348)

# Name Status NCT ID Phase Drugs
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
3 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
4 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
5 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
6 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
7 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
8 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
9 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
10 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
11 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
12 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
13 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4 acetylcysteine in arm 1
14 DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women Completed NCT01874158 Phase 4
15 Examining the Impact of Tampon Use on the Vaginal Microbiota Completed NCT03346759 Phase 4
16 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4 Desflurane;Sevoflurane
17 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
18 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
19 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4 Placebo
20 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
21 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
22 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
23 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
24 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
25 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
26 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
27 The Vaginal Health Trial Completed NCT02516202 Phase 4 Vagifem;Replens
28 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
29 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
30 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
31 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
32 The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis Recruiting NCT02905890 Phase 4 Norethisterone enantate
33 Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Recruiting NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
34 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Recruiting NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
35 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Recruiting NCT02445989 Phase 4 NuvaRing
36 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
37 Vaginal and Urinary Microbiome Trial Recruiting NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
38 Colposeptine for the Treatment of Bacterial Vaginosis Terminated NCT01153958 Phase 4 Colposeptine;Metronidazole
39 Safety and Efficacy Study of Gynevac Lactobacillus Vaccine in the Treatment of Bacterial Vaginosis Unknown status NCT02173184 Phase 3
40 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
41 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
42 Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis Unknown status NCT00889356 Phase 3 Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
43 The Effect of Probiotics on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients Unknown status NCT00536848 Phase 2, Phase 3 Metronidazole
44 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
45 Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections Unknown status NCT02186145 Phase 3 Association of metronidazole; nystatin and dexamethasone;Flagyl
46 Maternal Genitourinary Infections and Adverse Perinatal Outcomes Unknown status NCT01572532 Phase 3
47 Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis Unknown status NCT01420510 Phase 2, Phase 3 Adelmidrol vaginal gel;Placebo vaginal gel
48 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
49 Botulinum Toxin Injection for Treatment of Vaginismus Unknown status NCT00638066 Phase 3 botulinum toxin;botulinum toxin A
50 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3

Search NIH Clinical Center for Vaginal Disease

Cochrane evidence based reviews: vaginal diseases

Genetic Tests for Vaginal Disease

Anatomical Context for Vaginal Disease

MalaCards organs/tissues related to Vaginal Disease:

38
Testes, Colon, Uterus, T Cells, Bone, Prostate

Publications for Vaginal Disease

Articles related to Vaginal Disease:

# Title Authors Year
1
Global availability of data on HPV genotype-distribution in cervical, vulvar and vaginal disease and genotype-specific prevalence and incidence of HPV infection in females. ( 25987893 )
2015
2
Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease. ( 22454090 )
2012
3
Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. ( 22292563 )
2012
4
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme. ( 16800255 )
2006
5
Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. ( 10814580 )
2000
6
Vaginal disease. Venereal and nonvenereal types. ( 6601795 )
1983
7
Asymptomatic vaginal disease in pregnancy. ( 4825885 )
1974

Variations for Vaginal Disease

Expression for Vaginal Disease

Search GEO for disease gene expression data for Vaginal Disease.

Pathways for Vaginal Disease

Pathways related to Vaginal Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 CXCL8 DEFB4A IL1B IL6
2
Show member pathways
11.96 CXCL8 IL1B IL6
3 11.82 CXCL8 IL1B IL6
4 11.79 CXCL8 IL1B IL6
5 11.75 CXCL8 IL1B IL6
6 11.71 CXCL8 IL1B IL6
7 11.68 CXCL8 IL1B IL6
8 11.63 CXCL8 IL1B IL6
9 11.53 CXCL8 IL1B IL6
10
Show member pathways
11.47 CXCL8 DEFB4A IL1B IL6
11 11.43 CXCL8 IL1B IL6
12
Show member pathways
11.41 CXCL8 IL1B IL6
13 11.28 CXCL8 IL1B IL6
14 11.12 CXCL8 IL1B IL6
15 11.02 CXCL8 IL1B IL6
16 10.86 CXCL8 IL6
17 10.86 CXCL8 FLNA IL1B IL6
18 10.85 CXCL8 EZR IL1B IL6
19 10.59 IL1B IL6

GO Terms for Vaginal Disease

Cellular components related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 DEFB4A EZR IL1B IL6 SERPINH1
2 cell cortex GO:0005938 9.33 EZR FLNA SPTB
3 cortical cytoskeleton GO:0030863 9.26 EZR FLNA
4 extracellular region GO:0005576 9.23 CXCL8 DEFB4A DSPP FLNA IL1B IL6

Biological processes related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.02 CXCL8 DEFB4A IL1B IL6 SLPI

Sources for Vaginal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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