MCID: VGN020
MIFTS: 41

Vaginal Disease malady

Categories: Reproductive diseases

Aliases & Classifications for Vaginal Disease

Aliases & Descriptions for Vaginal Disease:

Name: Vaginal Disease 12 14
Vaginal Diseases 41 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:121
MeSH 42 D014623
NCIt 47 C26910
UMLS 69 C0042251

Summaries for Vaginal Disease

MedlinePlus : 41 vaginal problems are some of the most common reasons women go to the doctor. they may have symptoms such as itching burning pain abnormal bleeding discharge one common problem is vaginitis, an inflammation of the vagina. other problems that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. treatment of vaginal problems depends on the cause.

MalaCards based summary : Vaginal Disease, also known as vaginal diseases, is related to tau syndrome and oculomotor nerve paralysis, and has symptoms including leukorrhea and pelvic pain. An important gene associated with Vaginal Disease is EZR (Ezrin), and among its related pathways/superpathways are Allograft rejection and IL-17 Family Signaling Pathways. The drugs Acetaminophen and Acetylcysteine have been mentioned in the context of this disorder. Related phenotypes are immune system and mortality/aging

Wikipedia : 71 A vaginal disease is a pathological condition that affects part or all of the vagina. Some can be... more...

Related Diseases for Vaginal Disease

Diseases related to Vaginal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 tau syndrome 10.3 IL1B PRF1
2 oculomotor nerve paralysis 10.2 CXCL8 IL1B IL6
3 common peroneal nerve lesion 10.2 CXCL8 IL1B IL6
4 autosomal recessive type iv ehlers-danlos syndrome 10.2 CXCL8 IL1B IL6
5 labyrinthitis 10.2 CXCL8 IL1B IL6
6 atrophy of prostate 10.2 CXCL8 IL1B IL6
7 chordoid meningioma 10.2 CXCL8 IL1B IL6
8 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL6
9 choroiditis 10.2 CXCL8 IL1B IL6
10 nasopharyngitis 10.2 CXCL8 IL1B IL6
11 breast apocrine carcinoma in situ 10.2 CXCL8 IL1B IL6
12 infancy electroclinical syndrome 10.2 CXCL8 IL1B IL6
13 baritosis 10.2 CXCL8 IL1B IL6
14 colon adenocarcinoma 10.2 CXCL8 IL1B IL6
15 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6
16 classic type lipoma 10.2 CXCL8 IL1B IL6
17 conjunctival concretion 10.2 CXCL8 IL1B IL6
18 lateral cystocele 10.2 CXCL8 IL6 PRF1
19 blue toe syndrome 10.2 CXCL8 IL1B IL6
20 parasitic protozoa infectious disease 10.2 CXCL8 IL1B IL6
21 keratomalacia 10.2 CXCL8 IL1B IL6
22 lichen disease 10.2 CXCL8 IL1B IL6
23 optic nerve hypoplasia 10.2 CXCL8 IL1B IL6
24 nephropathy with pretibial epidermolysis bullosa and deafness 10.2 CXCL8 IL1B IL6
25 sclerosing adenosis of breast 10.2 CXCL8 IL1B IL6
26 occlusion of gallbladder 10.2 IL6 SERPINH1
27 pyoderma gangrenosum 10.2 CXCL8 IL1B IL6
28 vitreoretinopathy, neovascular inflammatory 10.2 CXCL8 IL6 SERPINH1
29 synovium cancer 10.2 CXCL8 IL1B IL6
30 pigmentation disease 10.2 CXCL8 IL1B IL6
31 bare lymphocyte syndrome, type i 10.2 CXCL8 IL1B IL6
32 uterine ligament clear cell adenocarcinoma 10.2 CXCL8 IL1B IL6
33 pulmonary eosinophilia 10.2 CXCL8 IL1B IL6
34 nervous system cancer 10.1 CXCL8 IL1B IL6
35 human immunodeficiency virus infectious disease 10.1 CD4 IL1B IL6
36 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 CD4 IL1B IL6
37 bacterial gastritis 10.1 CXCL8 DEFB4A IL1B
38 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 CD4 IL1B IL6
39 cholera 10.1 CD4 IL1B IL6
40 balkan nephropathy 10.1 CD4 CXCL8 IL1B
41 splenic artery aneurysm 10.1 CD4 IL1B IL6
42 tuberculosis 10.1 CD4 IL1B IL6
43 psychotic disorder 10.1 CXCL8 IL6
44 stenosis of lacrimal sac 10.1 CXCL8 DEFB4A IL1B IL6
45 sclerosing cholangitis 10.1 CD4 CXCL8 DEFB4A
46 anterior foramen magnum meningioma 10.1 CD4 IL1B IL6
47 phlyctenulosis 10.1 CD4 IL6 PRF1
48 histiocytosis 10.1 CXCL8 DEFB4A IL1B IL6
49 cysticercosis 10.1 CD4 EXTL3
50 intratubular embryonal carcinoma 10.1 CXCL8 DEFB4A IL1B IL6

Graphical network of the top 20 diseases related to Vaginal Disease:



Diseases related to Vaginal Disease

Symptoms & Phenotypes for Vaginal Disease

UMLS symptoms related to Vaginal Disease:


leukorrhea, pelvic pain

MGI Mouse Phenotypes related to Vaginal Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.61 FLNA IL1B IL6 LAP3 PRF1 SLPI
2 mortality/aging MP:0010768 9.32 CD4 EXTL3 EZR FLNA IL1B IL6

Drugs & Therapeutics for Vaginal Disease

Drugs for Vaginal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 670)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 443-48-1 4173
4
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 18323-44-9 29029
5
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
7
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Phase 1 57-63-6 5991
8
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
9
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
10
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
11
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
12
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
13
Lymecycline Approved Phase 4 992-21-2 5280963
14
Tetracycline Approved, Vet_approved Phase 4,Phase 3 60-54-8 5353990
15 Dienogest Approved Phase 4,Phase 3 65928-58-7
16
Goserelin Approved Phase 4,Phase 3 65807-02-5 47725 5311128
17
Nandrolone Approved, Experimental, Illicit Phase 4,Phase 3 434-22-0, 62-90-8 9904 229455
18
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3 360-70-3 9677
19
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 19387-91-8 5479
20
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
21
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
22
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 9552079 2713
23
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
24
Fluconazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
25
Levonorgestrel Approved, Investigational Phase 4,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
26
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
27
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
28
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
29
Benzocaine Approved Phase 4,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
30
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2180-92-9, 38396-39-3 2474
31
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
32
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 3911 657181
33
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-56-6 439302 53477758
34
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
35
Carbetocin Approved Phase 4,Phase 3,Early Phase 1 37025-55-1 71715 16681432
36
Norethindrone Approved Phase 4,Phase 2 68-22-4 6230
37
Misoprostol Approved Phase 4,Phase 3,Phase 2,Phase 1 59122-46-2 5282381
38
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3 155213-67-5 392622
39
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2 112809-51-5 3902
40
Desflurane Approved Phase 4 57041-67-5 42113
41
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
42
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
43
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
44
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 23593-75-1 2812
45
Norelgestromin Approved Phase 4 53016-31-2 13752005
46
Terconazole Approved Phase 4,Phase 3,Early Phase 1 67915-31-5 441383
47 Dequalinium Approved Phase 4,Phase 3 6707-58-0
48
Dinoprostone Approved Phase 4,Phase 3,Phase 2 363-24-6 5280360
49
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 71-58-9
50
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091

Interventional clinical trials:

(show top 50) (show all 1688)
id Name Status NCT ID Phase
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4
3 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4
4 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
5 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
6 Low Dose Estriol With Lactobacilli Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women Unknown status NCT00900653 Phase 4
7 Transvaginal Cholecystectomy Versus Laparoscopic Cholecystectomy in Patients With Biliary Colic Unknown status NCT00963950 Phase 4
8 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4
9 Assessment of Implantation Potential of Embryos by Time-lapse Technology Unknown status NCT01760278 Phase 4
10 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4
11 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
12 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
13 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4
14 Pharmacological vs Surgical Treatment for Mixed Incontinence Unknown status NCT00523068 Phase 4
15 Upper Vaginectomy Versus Brachytherapy in Patients With Early Stage Endometrial Cancer Treated With Laparoscopic Surgery Unknown status NCT00719017 Phase 4
16 Interest of Intravaginal Electro-stimulation at Home by GYNEFFIK® Compared to Usual Care in Incontinent Patients With Prior Perineal Reeducation Unknown status NCT02029027 Phase 4
17 The Treatment of Bartholin´s Cyst or Abscess With Silver Nitrate Unknown status NCT00786461 Phase 4
18 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
19 Postpartum Oxygen Inhalation for the Treatment of Postpartum Haemorrhage Unknown status NCT01180192 Phase 4
20 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
21 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
22 Autologous Versus Synthetic Versus Biological Sling for Trans-obturator Correction of Urinary Stress Incontinence Unknown status NCT00744198 Phase 4
23 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4
24 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4
25 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4
26 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4
27 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4
28 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4
29 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4
30 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4
31 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4
32 DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women Completed NCT01874158 Phase 4
33 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4
34 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4
35 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
36 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4
37 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4
38 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4
39 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4
40 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4
41 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4
42 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4
43 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4
44 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
45 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
46 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction Completed NCT00843362 Phase 4
47 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
48 Effectiveness of Intracavitary Manual Lymphatic Drainage Completed NCT02960841 Phase 4
49 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
50 Sexual Absorption of Vaginal Progesterone Completed NCT01959464 Phase 4

Search NIH Clinical Center for Vaginal Disease

Cochrane evidence based reviews: vaginal diseases

Genetic Tests for Vaginal Disease

Anatomical Context for Vaginal Disease

Publications for Vaginal Disease

Articles related to Vaginal Disease:

id Title Authors Year
1
Global availability of data on HPV genotype-distribution in cervical, vulvar and vaginal disease and genotype-specific prevalence and incidence of HPV infection in females. ( 25987893 )
2015
2
Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease. ( 22454090 )
2012
3
Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. ( 22292563 )
2012
4
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme. ( 16800255 )
2006
5
Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. ( 10814580 )
2000
6
Vaginal disease. Venereal and nonvenereal types. ( 6601795 )
1983
7
Asymptomatic vaginal disease in pregnancy. ( 4825885 )
1974

Variations for Vaginal Disease

Expression for Vaginal Disease

Search GEO for disease gene expression data for Vaginal Disease.

Pathways for Vaginal Disease

Pathways related to Vaginal Disease according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CD4 CXCL8 IL1B IL6 PRF1
2
Show member pathways
12.07 CXCL8 DEFB4A IL1B IL6
3
Show member pathways
12.01 CXCL8 IL1B IL6
4 11.87 CXCL8 IL1B IL6
5 11.84 CXCL8 IL1B IL6
6
Show member pathways
11.81 CD4 FLNA PRF1
7
Show member pathways
11.8 CD4 IL1B IL6
8 11.79 CXCL8 IL1B IL6
9
Show member pathways
11.76 CD4 IL1B IL6
10 11.74 CXCL8 IL1B IL6
11 11.72 CD4 IL1B IL6
12 11.71 CXCL8 IL1B IL6
13 11.67 CXCL8 IL1B IL6
14
Show member pathways
11.67 CXCL8 DEFB4A IL1B IL6
15 11.58 CD4 IL1B IL6
16 11.57 CXCL8 IL1B IL6
17 11.45 CXCL8 IL1B IL6
18
Show member pathways
11.43 CXCL8 IL1B IL6
19 11.32 CXCL8 IL1B IL6
20 11.19 CXCL8 IL1B IL6
21 11.12 CXCL8 IL1B IL6
22 10.91 CXCL8 IL6
23 10.9 CXCL8 EZR IL1B IL6
24 10.86 CXCL8 FLNA IL1B IL6
25 10.78 IL1B IL6
26 10.61 CD4 IL1B IL6

GO Terms for Vaginal Disease

Cellular components related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CXCL8 DEFB4A DSPP FLNA IL1B IL6
2 cell cortex GO:0005938 9.33 EZR FLNA SPTB
3 extracellular space GO:0005615 9.17 CXCL8 DEFB4A EZR IL1B IL6 SERPINH1

Biological processes related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.33 CD4 IL1B IL6
2 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.26 CD4 IL1B
3 defense response to Gram-negative bacterium GO:0050829 9.13 CD4 DEFB4A IL6
4 immune response GO:0006955 9.1 CD4 CXCL8 DEFB4A IL1B IL6 SLPI

Molecular functions related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin filament binding GO:0051015 8.8 EZR FLNA SPTB

Sources for Vaginal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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