Aliases & Classifications for Vaginal Disease

MalaCards integrated aliases for Vaginal Disease:

Name: Vaginal Disease 12 14
Vaginal Diseases 41 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:121
MeSH 42 D014623
NCIt 47 C26910
UMLS 69 C0042251

Summaries for Vaginal Disease

MedlinePlus : 41 vaginal problems are some of the most common reasons women go to the doctor. they may have symptoms such as itching burning pain abnormal bleeding discharge one common problem is vaginitis, an inflammation of the vagina. other problems that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. treatment of vaginal problems depends on the cause.

MalaCards based summary : Vaginal Disease, also known as vaginal diseases, is related to tabatznik syndrome and lacrimal apparatus disease, and has symptoms including leukorrhea and pelvic pain. An important gene associated with Vaginal Disease is EZR (Ezrin), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Immune response IFN alpha/beta signaling pathway. The drugs Acetylcysteine and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and bone, and related phenotype is immune system.

Wikipedia : 72 A vaginal disease is a pathological condition that affects part or all of the vagina. Some can be... more...

Related Diseases for Vaginal Disease

Diseases related to Vaginal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 tabatznik syndrome 10.7 IL1B PRF1
2 lacrimal apparatus disease 10.7 CXCL8 IL1B
3 drug rash with eosinophilia and systemic symptoms 10.7 CXCL8 IL6
4 spirillary rat-bite fever 10.7 CXCL8 IL6
5 schwannoma of ureter 10.6 CXCL8 IL6
6 chancroid 10.6 CXCL8 IL1B
7 scrotal carcinoma 10.6 IL1B IL6
8 gonococcal keratitis 10.6 IL6 SERPINH1
9 psychotic disorder 10.6 CXCL8 IL6
10 x-linked dominant intellectual disability-epilepsy syndrome 10.6 IL1B IL6
11 cardiocranial syndrome 10.6 CXCL8 PRF1
12 congenital nonspherocytic hemolytic anemia 10.6 IL1B IL6
13 oculomotor nerve paralysis 10.5 CXCL8 IL1B IL6
14 common peroneal nerve lesion 10.5 CXCL8 IL1B IL6
15 ovarian mucinous adenofibroma 10.5 CXCL8 IL1B IL6
16 vacterl association 10.5 CXCL8 IL1B IL6
17 atrophy of prostate 10.5 CXCL8 IL1B IL6
18 choroiditis 10.5 CXCL8 IL1B IL6
19 endocervical type cervical mucinous adenocarcinoma 10.5 CXCL8 IL1B IL6
20 autosomal recessive type iv ehlers-danlos syndrome 10.5 CXCL8 IL1B IL6
21 neonatal period electroclinical syndrome 10.5 CXCL8 IL1B IL6
22 conjunctival concretion 10.5 CXCL8 IL1B IL6
23 asbestosis 10.5 CXCL8 IL1B IL6
24 colon adenocarcinoma 10.5 CXCL8 IL1B IL6
25 pleomorphic lipoma 10.5 CXCL8 IL1B IL6
26 ragweed sensitivity 10.5 CXCL8 IL1B IL6
27 blue toe syndrome 10.5 CXCL8 IL1B IL6
28 upper gum cancer 10.5 IL1B IL6
29 cerebellar disease 10.5 CXCL8 IL1B IL6
30 vallecula cancer 10.5 CXCL8 IL1B IL6
31 scabies 10.5 CXCL8 IL1B IL6
32 optic nerve hypoplasia 10.5 CXCL8 IL1B IL6
33 hyperpigmentation of eyelid 10.5 CXCL8 IL1B IL6
34 reticulosarcoma 10.5 CXCL8 IL1B IL6
35 synovium cancer 10.5 CXCL8 IL1B IL6
36 vulva fibroepithelial polyp 10.5 CXCL8 IL1B IL6
37 pulmonary embolism 10.5 CXCL8 IL1B IL6
38 acute myeloblastic leukemia without maturation 10.5 CXCL8 IL6
39 detrusor sphincter dyssynergia 10.4 CXCL8 IL1B IL6
40 anti-basement membrane glomerulonephritis 10.4 CD79A CXCL8
41 osteogenesis imperfecta, type x 10.4 CXCL8 IL6 SERPINH1
42 granulomatous orchitis 10.4 CXCL8 IL1B IL6
43 bipolar i disorder 10.4 IL1B IL6
44 toxic optic neuropathy 10.4 CD79A IL1B
45 dientamoebiasis 10.4 CXCL8 IL1B IL6
46 acute pancreatitis 10.4 CXCL8 IL1B IL6
47 carotid artery dissection 10.4 CXCL8 IL1B IL6
48 adenoid squamous cell carcinoma 10.4 CXCL8 IL1B IL6
49 epulis 10.4 CXCL8 DSPP IL1B
50 burn scar 10.4 CXCL8 DEFB4A IL6

Graphical network of the top 20 diseases related to Vaginal Disease:



Diseases related to Vaginal Disease

Symptoms & Phenotypes for Vaginal Disease

UMLS symptoms related to Vaginal Disease:


leukorrhea, pelvic pain

MGI Mouse Phenotypes related to Vaginal Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 PRF1 SLPI SPTB CD79A EZR FLNA

Drugs & Therapeutics for Vaginal Disease

Drugs for Vaginal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 464)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 443-48-1 4173
3
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 18323-44-9 29029
4
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
6
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3 57-63-6 5991
7
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
8
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 19387-91-8 5479
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
10
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
11
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 9552079 2713
12
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
13
Fluconazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
14
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
15
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
16
Desflurane Approved Phase 4 57041-67-5 42113
17
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
18
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
19
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
20
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 23593-75-1 2812
21
Norelgestromin Approved Phase 4 53016-31-2 13752005
22
Terconazole Approved Phase 4,Phase 3,Early Phase 1 67915-31-5 441383
23
Dequalinium Approved Phase 4,Phase 3 6707-58-0
24
Dinoprostone Approved Phase 4,Phase 3,Phase 2 363-24-6 5280360
25
Ephedrine Approved Phase 4,Phase 2,Phase 3 299-42-3 9294
26
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3 90-82-4 7028
27
Tamoxifen Approved Phase 4,Phase 3,Phase 2 10540-29-1 2733526
28
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
29 Dolutegravir Approved Phase 4,Phase 1 1051375-16-6 54726191
30
Efavirenz Approved, Investigational Phase 4,Phase 2 154598-52-4 64139
31
Nevirapine Approved Phase 4,Phase 3 129618-40-2 4463
32
Ritonavir Approved, Investigational Phase 4,Phase 2 155213-67-5 392622
33
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 1 56-81-5 753
34
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
35
Estrone Approved Phase 4 53-16-7 5870
36
Amikacin Approved, Vet_approved Phase 4 37517-28-5 37768
37
Aminosalicylic Acid Approved Phase 4 65-49-6 4649
38
Bedaquiline Approved Phase 4 843663-66-1
39
Capreomycin Approved Phase 4 11003-38-6 3000502
40
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
41
Cobicistat Approved Phase 4 1004316-88-4
42
Cycloserine Approved Phase 4 68-41-7 401 6234
43
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
44
Ethambutol Approved Phase 4 74-55-5 3279 14052
45
Ethionamide Approved Phase 4 536-33-4 2761171
46
Etravirine Approved Phase 4 269055-15-4 193962
47
Isoniazid Approved Phase 4 54-85-3 3767
48
Kanamycin Approved, Vet_approved Phase 4 8063-07-8, 59-01-8 6032
49
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
50
Linezolid Approved, Investigational Phase 4 165800-03-3 441401

Interventional clinical trials:

(show top 50) (show all 607)

id Name Status NCT ID Phase Drugs
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
3 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
4 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
5 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
6 Low Dose Estriol With Lactobacilli Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women Unknown status NCT00900653 Phase 4 Gynoflor E (low dose estriol with lactobacillus)
7 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
8 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
9 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
10 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
11 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
12 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
13 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
14 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
15 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4 acetylcysteine in arm 1
16 DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women Completed NCT01874158 Phase 4
17 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4 Desflurane;Sevoflurane
18 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
19 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
20 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4 Placebo
21 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
22 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
23 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
24 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
25 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
26 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
27 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
28 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
29 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
30 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction Completed NCT00843362 Phase 4 Dinoprostone vaginal pessary;Dinoprostone vaginal gel
31 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
32 Effectiveness of Intracavitary Manual Lymphatic Drainage Completed NCT02960841 Phase 4
33 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
34 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
35 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
36 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Recruiting NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
37 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Recruiting NCT02445989 Phase 4 NuvaRing
38 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
39 Vaginal and Urinary Microbiome Trial Recruiting NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
40 Role of Progesterone in Hypoactive Sexual Desire Disorder in Menopausal Women Recruiting NCT02968342 Phase 4
41 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
42 Ospemifene vs. Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction Recruiting NCT03018106 Phase 4 Ospemifene;Vaginal conjugated estrogens
43 Electrosurgical Unipolar Vessel Sealing in Vaginal Hysterectomy Recruiting NCT03228654 Phase 4
44 Patient Adherence to Premarin Versus Vagifem Therapy After Female Pelvic Reconstructive Surgery Recruiting NCT02860897 Phase 4 Premarin;Vagifem
45 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
46 Permanent Versus Absorbable Colpopexy Trial Recruiting NCT02277925 Phase 4
47 Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy Recruiting NCT00042289 Phase 4 atazanavir/cobicistat;darunavir/ritonavir;darunavir/cobicistat;etravirine;elvitegravir/cobicistat;dolutegravir;tenofovir alafenamide fumarate (TAF);TAF/cobicistat;TAF/ritonavir;efavirenz;lopinavir/ritonavir;nevirapine;rifampicin;ethambutol;isoniazid;pyrazinamide;rifampicin;kanamycin;amikacin;capreomycin;moxifloxacin;levofloxacin;ofloxacin;ethionamide/prothionamide;terizidone/cycloserine;para-aminosalicylic acid (PAS);high dose isoniazid (INH);bedaquiline;clofazamine;delamanid;linezolid;pretomanid;atazanavir/ritonavir/tenofovir;ethinyl estradiol oral contraceptive;etonogestrel implant
48 The Vaginal Health Trial Active, not recruiting NCT02516202 Phase 4 Vagifem;Replens
49 Effects of Oral vs. Non-oral Contraceptives on the GH/IGF-1 Axis Active, not recruiting NCT02367833 Phase 4 Combined Oral Contraceptive;Transdermal Contraceptive;Contraceptive Vaginal Ring
50 Assessing the Impact of Contraceptives on Bone Health Using 41Ca Active, not recruiting NCT02367846 Phase 4 Combined Oral Contraceptive (COC);Contraceptive Vaginal Ring (CVR)

Search NIH Clinical Center for Vaginal Disease

Cochrane evidence based reviews: vaginal diseases

Genetic Tests for Vaginal Disease

Anatomical Context for Vaginal Disease

MalaCards organs/tissues related to Vaginal Disease:

39
Testes, Colon, Bone, Heart, T Cells, Uterus, Myeloid

Publications for Vaginal Disease

Articles related to Vaginal Disease:

id Title Authors Year
1
Global availability of data on HPV genotype-distribution in cervical, vulvar and vaginal disease and genotype-specific prevalence and incidence of HPV infection in females. ( 25987893 )
2015
2
Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. ( 22292563 )
2012
3
Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease. ( 22454090 )
2012
4
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme. ( 16800255 )
2006
5
Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. ( 10814580 )
2000
6
Vaginal disease. Venereal and nonvenereal types. ( 6601795 )
1983
7
Asymptomatic vaginal disease in pregnancy. ( 4825885 )
1974

Variations for Vaginal Disease

Expression for Vaginal Disease

Search GEO for disease gene expression data for Vaginal Disease.

Pathways for Vaginal Disease

Pathways related to Vaginal Disease according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 CXCL8 DEFB4A IL1B IL6
2
Show member pathways
11.96 CXCL8 IL1B IL6
3 11.82 CXCL8 IL1B IL6
4 11.79 CXCL8 IL1B IL6
5 11.75 CXCL8 IL1B IL6
6 11.71 CXCL8 IL1B IL6
7 11.68 CXCL8 IL1B IL6
8 11.63 CXCL8 IL1B IL6
9 11.53 CXCL8 IL1B IL6
10
Show member pathways
11.47 CXCL8 DEFB4A IL1B IL6
11 11.43 CXCL8 IL1B IL6
12
Show member pathways
11.41 CXCL8 IL1B IL6
13 11.28 CXCL8 IL1B IL6
14 11.12 CXCL8 IL1B IL6
15 11.02 CXCL8 IL1B IL6
16 10.86 CXCL8 IL6
17 10.86 CXCL8 FLNA IL1B IL6
18 10.85 CXCL8 EZR IL1B IL6
19 10.69 IL1B IL6

GO Terms for Vaginal Disease

Cellular components related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 DEFB4A EZR IL1B IL6 SERPINH1
2 cell cortex GO:0005938 9.33 EZR FLNA SPTB
3 extracellular region GO:0005576 9.23 CXCL8 DEFB4A DSPP FLNA IL1B IL6

Biological processes related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.02 CXCL8 DEFB4A IL1B IL6 SLPI

Molecular functions related to Vaginal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin filament binding GO:0051015 8.8 EZR FLNA SPTB

Sources for Vaginal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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