MCID: VGN023
MIFTS: 62

Vaginitis malady

Reproductive diseases category
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Summaries for Vaginitis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often... more...

MalaCards: Vaginitis, also known as vaginitis and vulvovaginitis, is related to adenocarcinoma and leiomyoma. An important gene associated with Vaginitis is SH2D1A (SH2 domain containing 1A), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Plasma membrane estrogen receptor signaling. The compounds r,r-thc and 17alpha estradiol have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and colon, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Aliases & Classifications for Vaginitis

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

vaginitis 8
vaginitis and vulvovaginitis 8
vaginitis unspecified 8
vaginitis - non sp. 8
infective vaginitis 62
vaginitis nos 8


External Ids:

Disease Ontology8 DOID:2170
MeSH35 D014627
NCIt40 C26911

Related Diseases for Vaginitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Vaginitis:



Diseases related to vaginitis

Symptoms for Vaginitis

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Drugs & Therapeutics for Vaginitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Vaginitis

Search NIH Clinical Center for Vaginitis

Genetic Tests for Vaginitis

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Anatomical Context for Vaginitis

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33MalaCards
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MalaCards organs/tissues related to Vaginitis:

33
Testes, Uterus, Colon, Cervix, Placenta, Kidney, Ovary, Bone, Breast, Liver, T cells, Myeloid, Lymph node, Skin, Prostate, Smooth muscle, Heart, Thyroid, Monocytes, Lung, Pituitary

Animal Models for Vaginitis or affiliated genes

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37MGI
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Publications for Vaginitis

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52PubMed
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Articles related to Vaginitis:

(show top 50)    (show all 2131)
idTitleAuthorsYear
1
The role of physical examination in diagnosing common causes of vaginitis: a prospective study. (23019659)
2013
2
Co-infections with Ureaplasma parvum, Mycoplasma hominis and Chlamydia trachomatis in a human immunodeficiency virus positive woman with vaginal discharge. (23867681)
2013
3
Dosimetric comparison of multichannel with one single-channel vaginal cylinder for vaginal cancer treatments with high-dose-rate brachytherapy. (24080298)
2013
4
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
5
Influence of anaerobic conditions on vaginal microbiota recovery from bacterial vaginosis patients. (23687135)
2013
6
Temporary endovascular balloon occlusion of the bilateral internal iliac arteries to control hemorrhage during laparoscopic-assisted vaginal hysterectomy for cervical myoma. (21658835)
2011
7
The prognostic role of human papillomavirus in patients with vaginal cancer. (21666483)
2011
8
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. (20805398)
2010
9
Early vaginal bleeding has no impact on markers used in first trimester aneuploidy screening. (20509154)
2010
10
A girl of Klippel-Trenaunay Weber syndrome coexistence of recurrent bloody vaginal discharge. (19768566)
2010
11
Expression of occludin and zona occluden-1 and their morphologic changes in vagina mucosal cells in patients undergoing vaginal construction by using sigmoid colon]. (20003786)
2009
12
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
13
Fetal acidosis from obstetric interventions during the first vaginal delivery. (19126504)
2008
14
Concurrent imperforate hymen, transverse vaginal septum, and unicornuate uterus: a case report. (17706513)
2007
15
Vaginal fibrosarcoma in a cow. (21851697)
2007
16
Analysis of vaginal recurrences in stage I endometrial adenocarcinoma. (17713101)
2007
17
Does vaginal bleeding influence first-trimester markers for Down syndrome? (17286311)
2007
18
Molecular evidence of congenital candidiasis associated with maternal candidal vaginitis. (16804443)
2006
19
Influence of exogenous reproductive hormones on specific antibody production in genital secretions after vaginal vaccination with recombinant cholera toxin B subunit in humans. (16467326)
2006
20
Cervical Cancer Screening for the Reluctant - HPV Testing of Air-Dried Vaginal Discharge. (23675011)
2006
21
Effect of pepstatin A on the virulence factors of Candida albicans strains isolated from vaginal environment of patients in three different clinical conditions. (16897584)
2006
22
Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients. (16006060)
2005
23
Information from your family doctor. Vaginitis. (15606062)
2004
24
Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth. (15507961)
2004
25
Vaginal misoprostol for induction of labour: a more effective agent than prostaglandin F2 alpha gel and prostaglandin E2 pessary. (14562597)
2002
26
Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans. (11705923)
2001
27
Micro-ablepharon of the upper eyelids and vaginal atresia. (11332973)
2001
28
Vaginal depth following reconstruction with pudendal thigh flaps in congenital vaginal atresia. (9030179)
1997
29
Long-term efficacy and safety of a disposable vaginal device (continence guard) in the treatment of female stress incontinence. (9449583)
1997
30
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
31
Lactobacillus GG vaginal suppositories and vaginitis. (7615776)
1995
32
Depressed serum levels of human placental lactogen in first trimester vaginal bleeding. (7531935)
1995
33
Thymopentin and cervico-vaginal HPV infection associated with CIN]. (7478094)
1995
34
Gartner's duct cyst with a single vaginal ectopic ureter and associated renal dysplasia or agenesis. (8301720)
1993
35
Split-dose metronidazole or single-dose tinidazole for the treatment of vaginal trichomoniasis. (1411848)
1992
36
Evaluation of a latex agglutination test for the identification of Candida species in vaginal discharge. (1496893)
1992
37
Vaginitis. (1956016)
1991
38
The treatment of vaginal atresia. (2028378)
1991
39
Allergic vaginitis mimicking bacterial vaginosis. (1965569)
1990
40
Prevalence of common infective agents of vaginitis. (2614050)
1989
41
Vaginal discharge and cystitis. (3399160)
1988
42
The role of benzydamine in the topical treatment of the so-called non-specific vaginitis. (3497131)
1987
43
Vaginal discharge. (3098348)
1986
44
The challenges of vaginal atresia and stenosis: Nigerian experience. (6144585)
1984
45
Double blind comparative study of tinidazole and ornidazole as a single dose treatment of vaginal trichomoniasis. (7000949)
1980
46
Single-dose treatment of vaginal trichomoniasis with tinidazole. (4617665)
1974
47
A case of pyomucocolpos due to a transverse vaginal septum]. (5106198)
1971
48
'Gathering' of tunica vaginal in the surgical cure of idiopathic hydrocele. (5651615)
1968
49
Experimental induction of uterine cervical and vaginal cancer in mice. (13629482)
1959
50
Treatment of vaginitis and cervicitis by the general practitioner. (14807908)
1951

Variations for Vaginitis

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Expression for genes affiliated with Vaginitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vaginitis

Search GEO for disease gene expression data for Vaginitis.

Pathways for genes affiliated with Vaginitis

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 54R&D Systems
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Pathways related to Vaginitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ESR2, ESR1
29.5ESR2, ESR1
3
Show member pathways
9.5ESR1, ESR2
49.5ESR1, ESR2
59.5AR, IL1B
6
Show member pathways
FOXA transcription factor networks38
9.5AR, ESR1
79.3ESR1, ABCB1
89.1IL1B, IL10
99.1IL10, IL1B
109.1IL1B, IL10
11
Show member pathways
IL27-mediated signaling events38
9.1IL10, IL1B
129.1IL10, IL1B
139.1IL1B, IL10
149.1IL10, IL1B
15
Show member pathways
Nuclear Receptors38
9.1AR, ESR1, ESR2
169.1AR, ESR1, ESR2
17
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.0IL1B, ESR1, ESR2
188.7ESR1, IL10, AR
198.5ABCB1, ESR2, ESR1, AR
208.3AR, IL1B, IL10, ESR2
21
Show member pathways
8.2ESR2, ESR1, IL10, IL1B

Compounds for genes affiliated with Vaginitis

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Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 11DrugBank, 3BitterDB
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Compounds related to Vaginitis according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1r,r-thc299.9ESR2, ESR1
217alpha estradiol459.9ESR2, ESR1
3ly 117018459.9ESR1, ESR2
4hpte45 2910.9AR, ESR2
5lasofoxifene459.9ESR1, ESR2
64-octylphenol459.9ESR2, ESR1
7isopropylparaben459.9ESR2, ESR1
8isobutylparaben459.9ESR1, ESR2
92,4,6-trichloro-4-biphenylol459.9ESR2, ESR1
10butylparaben459.8ESR1, ESR2
11methylparaben459.8ESR1, ESR2
12zeranol459.7ESR2, ESR1
134-hydroxy?aetamoxifen299.7ESR1, ESR2
14vinclozolin459.6ESR1, AR
15(z)-4-hydroxytamoxifen619.5ESR2, ESR1
164-tert-octylphenol459.5ESR1, ESR2, AR
17nandrolone45 2410.5ESR2, ESR1, AR
185alpha-androstane-3alpha,17beta-diol459.5AR, ESR1, ESR2
19exemestane45 51 61 1112.5ESR2, ESR1, AR
20bisphenol a459.5AR, ESR2, ESR1
21radicicol45 61 1111.5ESR1, DLAT, AR
22fulvestrant45 51 29 1112.5ESR2, ESR1, AR
23letrozole45 51 61 1112.5ESR2, AR, ESR1
24levonorgestrel45 61 29 1112.5ESR1, ESR2, AR
25bicalutamide45 61 1111.5ESR1, ESR2, AR
26steroidal459.5AR, ESR1, ESR2
2717beta-estradiol299.4ESR1, ESR2
2817beta-hydroxysteroid459.3AR, ESR1, ESR2
29naringenin45 1110.3ESR2, ESR1, ABCB1
30toremifene45 1110.3ESR2, ESR1, ABCB1
31estriol29 24 1111.3ESR2, ESR1, ABCB1
32progestins459.3AR, ESR1, ESR2
33lapatinib45 51 1111.3ABCB1, ESR1, AR
34ici 182,780619.2ESR1, ESR2
35estramustine45 119.9ABCB1, AR, ESR2, ESR1
36diethylstilbestrol45 29 1110.9ABCB1, ESR2, AR, ESR1
37estrone45 29 24 1111.9AR, ESR1, ABCB1, ESR2
38dihydrotestosterone45 29 24 1111.9ABCB1, ESR2, ESR1, AR
39tamoxifen45 51 29 1111.7ESR1, ESR2, ABCB1, AR
40ibuprofen45 29 51 24 1112.6IL1B, ABCB1, IL10
41vitamin d458.5ESR1, ESR2, IL10, AR
42mifepristone45 29 61 1111.4ABCB1, ESR2, ESR1, IL1B, AR
43actinomycin d458.4ABCB1, ESR2, ESR1, IL1B, AR
44genistein45 29 61 3 24 1113.4AR, ESR1, ESR2, ABCB1, IL1B
45methotrexate51 45 1110.4ABCB1, ESR1, IL10, IL1B
46ly294002458.2ESR1, IL1B, AR, IL10
47cycloheximide458.1ESR2, ESR1, IL10, IL1B, AR
48quercetin45 61 24 1111.1AR, IL10, ESR2, ABCB1, IL1B
49vegf458.0IL10, ESR1, AR, IL1B, ESR2
50dexamethasone45 51 29 1111.0ESR2, IL10, IL1B, ABCB1, AR

GO Terms for genes affiliated with Vaginitis

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16Gene Ontology
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Biological processes related to Vaginitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.7ESR1, ESR2
2vagina developmentGO:0600689.7ESR1, ESR2
3intracellular estrogen receptor signaling pathwayGO:0305209.6ESR1, ESR2
4positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, IL1B
5cellular response to estradiol stimulusGO:0713929.3IL10, ESR1
6transcription initiation from RNA polymerase II promoterGO:0063679.2ESR2, ESR1, AR
7positive regulation of transcription, DNA-templatedGO:0458938.7AR, IL1B, IL10
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.4ESR2, ESR1, IL10, IL1B
9signal transductionGO:0071658.3AR, IL1B, ESR1, ESR2
10cell-cell signalingGO:0072678.2AR, IL1B, IL10, ESR2, SH2D1A
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.2AR, IL1B, IL10, ESR1

Molecular functions related to Vaginitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:0340569.7ESR1, ESR2
2estrogen receptor activityGO:0302849.7ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:0010469.7ESR1, ESR2
4steroid bindingGO:0054969.6ESR1, ESR2
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5AR, ESR2
6beta-catenin bindingGO:0080139.5AR, ESR1
7steroid hormone receptor activityGO:0037079.2ESR1, ESR2
8enzyme bindingGO:0198999.1ESR2, ESR1, AR

Products for genes affiliated with Vaginitis

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Sources for Vaginitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet