MCID: VGN023
MIFTS: 63

Vaginitis malady

Reproductive diseases category
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Summaries for Vaginitis

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Wikipedia:65 Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often... more...

MalaCards based summary: Vaginitis, also known as vaginitis nos, is related to adenosarcoma and endometrial carcinoma. An important gene associated with Vaginitis is SH2D1A (SH2 domain containing 1A), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Plasma membrane estrogen receptor signaling. The compounds r,r-thc and 17alpha estradiol have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and cervix, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Aliases & Classifications for Vaginitis

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Vaginitis, Aliases & Descriptions:

Name: Vaginitis 8
Vaginitis Nos 8 62
Vaginitis and Vulvovaginitis 8
 
Vaginitis Unspecified 8
Infective Vaginitis 62
Vaginitis - Non Sp. 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:2170
MeSH34 D014627
NCIt39 C26911

Related Diseases for Vaginitis

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Graphical network of the top 20 diseases related to Vaginitis:



Diseases related to vaginitis

Symptoms for Vaginitis

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Drugs & Therapeutics for Vaginitis

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Drug clinical trials:

Search ClinicalTrials for Vaginitis

Search NIH Clinical Center for Vaginitis

Genetic Tests for Vaginitis

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Anatomical Context for Vaginitis

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MalaCards organs/tissues related to Vaginitis:

32
Testes, Uterus, Cervix, Colon, Placenta, Neutrophil, Kidney, Ovary, Bone, Liver, Breast, T cells, Lymph node, Skin, Myeloid, Heart, Smooth muscle, Prostate, Lung, Thyroid, Monocytes, Pituitary

Animal Models for Vaginitis or affiliated genes

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Publications for Vaginitis

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Articles related to Vaginitis:

(show top 50)    (show all 2218)
idTitleAuthorsYear
1
Accounting for Anovulation and Vaginal Thinning During Depot Medroxyprogesterone Acetate Use. (25217405)
2014
2
Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis. (25315503)
2014
3
The role of physical examination in diagnosing common causes of vaginitis: a prospective study. (23019659)
2013
4
Co-infections with Ureaplasma parvum, Mycoplasma hominis and Chlamydia trachomatis in a human immunodeficiency virus positive woman with vaginal discharge. (23867681)
2013
5
Dosimetric comparison of multichannel with one single-channel vaginal cylinder for vaginal cancer treatments with high-dose-rate brachytherapy. (24080298)
2013
6
Innate immunity in the vagina (part I): estradiol inhibits HBD2 and elafin secretion by human vaginal epithelial cells. (23398087)
2013
7
Spectrum of vaginal discharge in a tertiary care setting. (24470998)
2013
8
Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. (24265786)
2013
9
Temporary endovascular balloon occlusion of the bilateral internal iliac arteries to control hemorrhage during laparoscopic-assisted vaginal hysterectomy for cervical myoma. (21658835)
2011
10
The prognostic role of human papillomavirus in patients with vaginal cancer. (21666483)
2011
11
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. (20805398)
2010
12
Early vaginal bleeding has no impact on markers used in first trimester aneuploidy screening. (20509154)
2010
13
Expression of occludin and zona occluden-1 and their morphologic changes in vagina mucosal cells in patients undergoing vaginal construction by using sigmoid colon]. (20003786)
2009
14
Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. (19260253)
2009
15
Fetal acidosis from obstetric interventions during the first vaginal delivery. (19126504)
2008
16
Concurrent imperforate hymen, transverse vaginal septum, and unicornuate uterus: a case report. (17706513)
2007
17
Vaginal fibrosarcoma in a cow. (21851697)
2007
18
Analysis of vaginal recurrences in stage I endometrial adenocarcinoma. (17713101)
2007
19
Does vaginal bleeding influence first-trimester markers for Down syndrome? (17286311)
2007
20
Molecular evidence of congenital candidiasis associated with maternal candidal vaginitis. (16804443)
2006
21
Influence of exogenous reproductive hormones on specific antibody production in genital secretions after vaginal vaccination with recombinant cholera toxin B subunit in humans. (16467326)
2006
22
Cervical Cancer Screening for the Reluctant - HPV Testing of Air-Dried Vaginal Discharge. (23675011)
2006
23
Effect of pepstatin A on the virulence factors of Candida albicans strains isolated from vaginal environment of patients in three different clinical conditions. (16897584)
2006
24
Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients. (16006060)
2005
25
Information from your family doctor. Vaginitis. (15606062)
2004
26
Vaginal misoprostol for induction of labour: a more effective agent than prostaglandin F2 alpha gel and prostaglandin E2 pessary. (14562597)
2002
27
Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans. (11705923)
2001
28
Micro-ablepharon of the upper eyelids and vaginal atresia. (11332973)
2001
29
Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium. (10084314)
1999
30
Vaginal depth following reconstruction with pudendal thigh flaps in congenital vaginal atresia. (9030179)
1997
31
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
32
Lactobacillus GG vaginal suppositories and vaginitis. (7615776)
1995
33
Depressed serum levels of human placental lactogen in first trimester vaginal bleeding. (7531935)
1995
34
Gartner's duct cyst with a single vaginal ectopic ureter and associated renal dysplasia or agenesis. (8301720)
1993
35
Split-dose metronidazole or single-dose tinidazole for the treatment of vaginal trichomoniasis. (1411848)
1992
36
Evaluation of a latex agglutination test for the identification of Candida species in vaginal discharge. (1496893)
1992
37
Vaginitis. (1956016)
1991
38
The treatment of vaginal atresia. (2028378)
1991
39
Allergic vaginitis mimicking bacterial vaginosis. (1965569)
1990
40
Prevalence of common infective agents of vaginitis. (2614050)
1989
41
Vaginal discharge and cystitis. (3399160)
1988
42
The role of benzydamine in the topical treatment of the so-called non-specific vaginitis. (3497131)
1987
43
Vaginal discharge. (3098348)
1986
44
The challenges of vaginal atresia and stenosis: Nigerian experience. (6144585)
1984
45
Double blind comparative study of tinidazole and ornidazole as a single dose treatment of vaginal trichomoniasis. (7000949)
1980
46
Single-dose treatment of vaginal trichomoniasis with tinidazole. (4617665)
1974
47
A case of pyomucocolpos due to a transverse vaginal septum]. (5106198)
1971
48
'Gathering' of tunica vaginal in the surgical cure of idiopathic hydrocele. (5651615)
1968
49
Experimental induction of uterine cervical and vaginal cancer in mice. (13629482)
1959
50
Treatment of vaginitis and cervicitis by the general practitioner. (14807908)
1951

Variations for Vaginitis

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Expression for genes affiliated with Vaginitis

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Expression patterns in normal tissues for genes affiliated with Vaginitis

Search GEO for disease gene expression data for Vaginitis.

Pathways for genes affiliated with Vaginitis

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Pathways related to Vaginitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ESR2, ESR1
29.5ESR2, ESR1
3
Show member pathways
9.5ESR1, ESR2
49.5ESR1, ESR2
59.5AR, IL1B
6
Show member pathways
FOXA transcription factor networks37
9.5AR, ESR1
79.3ESR1, ABCB1
89.1IL1B, IL10
99.1IL10, IL1B
109.1IL1B, IL10
11
Show member pathways
IL27-mediated signaling events37
9.1IL10, IL1B
129.1IL10, IL1B
139.1IL1B, IL10
149.1IL10, IL1B
15
Show member pathways
Nuclear Receptors37
9.1AR, ESR1, ESR2
169.1AR, ESR1, ESR2
17
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.0IL1B, ESR1, ESR2
188.7ESR1, IL10, AR
198.5ABCB1, ESR2, ESR1, AR
208.3AR, IL1B, IL10, ESR2
21
Show member pathways
8.2ESR2, ESR1, IL10, IL1B

Compounds for genes affiliated with Vaginitis

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Compounds related to Vaginitis according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1r,r-thc289.9ESR2, ESR1
217alpha estradiol449.9ESR2, ESR1
3ly 117018449.9ESR1, ESR2
4hpte44 2810.9AR, ESR2
5lasofoxifene449.9ESR1, ESR2
64-octylphenol449.9ESR2, ESR1
7isopropylparaben449.9ESR2, ESR1
8isobutylparaben449.9ESR1, ESR2
92,4,6-trichloro-4-biphenylol449.9ESR2, ESR1
10butylparaben449.8ESR1, ESR2
11methylparaben449.8ESR1, ESR2
12zeranol449.7ESR2, ESR1
134-hydroxy?aetamoxifen289.7ESR1, ESR2
14vinclozolin449.6ESR1, AR
15(z)-4-hydroxytamoxifen619.5ESR2, ESR1
164-tert-octylphenol449.5ESR1, ESR2, AR
17nandrolone44 2410.5ESR2, ESR1, AR
185alpha-androstane-3alpha,17beta-diol449.5AR, ESR1, ESR2
19exemestane44 50 61 1112.5ESR2, ESR1, AR
20bisphenol a449.5AR, ESR2, ESR1
21radicicol44 61 1111.5ESR1, DLAT, AR
22fulvestrant44 50 28 1112.5ESR2, ESR1, AR
23letrozole44 50 61 1112.5ESR2, AR, ESR1
24levonorgestrel44 61 28 1112.5ESR1, ESR2, AR
25bicalutamide44 61 1111.5ESR1, ESR2, AR
26steroidal449.5AR, ESR1, ESR2
2717beta-estradiol289.4ESR1, ESR2
2817beta-hydroxysteroid449.3AR, ESR1, ESR2
29naringenin44 1110.3ESR2, ESR1, ABCB1
30toremifene44 1110.3ESR2, ESR1, ABCB1
31estriol28 24 1111.3ESR2, ESR1, ABCB1
32progestins449.3AR, ESR1, ESR2
33lapatinib44 50 1111.3ABCB1, ESR1, AR
34ici 182,780619.2ESR1, ESR2
35estramustine44 119.9ABCB1, AR, ESR2, ESR1
36diethylstilbestrol44 28 1110.9ABCB1, ESR2, AR, ESR1
37estrone44 28 24 1111.9AR, ESR1, ABCB1, ESR2
38dihydrotestosterone44 28 24 1111.9ABCB1, ESR2, ESR1, AR
39tamoxifen44 50 28 1111.7ESR1, ESR2, ABCB1, AR
40ibuprofen44 28 50 24 1112.6IL1B, ABCB1, IL10
41vitamin d448.5ESR1, ESR2, IL10, AR
42mifepristone44 28 61 1111.4ABCB1, ESR2, ESR1, IL1B, AR
43actinomycin d448.4ABCB1, ESR2, ESR1, IL1B, AR
44genistein44 28 61 2 24 1113.4AR, ESR1, ESR2, ABCB1, IL1B
45methotrexate50 44 1110.4ABCB1, ESR1, IL10, IL1B
46ly294002448.2ESR1, IL1B, AR, IL10
47cycloheximide448.1ESR2, ESR1, IL10, IL1B, AR
48quercetin44 61 24 1111.1AR, IL10, ESR2, ABCB1, IL1B
49vegf448.0IL10, ESR1, AR, IL1B, ESR2
50dexamethasone44 50 28 1111.0ESR2, IL10, IL1B, ABCB1, AR

GO Terms for genes affiliated with Vaginitis

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Biological processes related to Vaginitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.7ESR1, ESR2
2vagina developmentGO:0600689.7ESR1, ESR2
3intracellular estrogen receptor signaling pathwayGO:0305209.6ESR1, ESR2
4positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, IL1B
5cellular response to estradiol stimulusGO:0713929.3IL10, ESR1
6transcription initiation from RNA polymerase II promoterGO:0063679.2ESR2, ESR1, AR
7positive regulation of transcription, DNA-templatedGO:0458938.7AR, IL1B, IL10
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.4ESR2, ESR1, IL10, IL1B
9signal transductionGO:0071658.3AR, IL1B, ESR1, ESR2
10cell-cell signalingGO:0072678.2AR, IL1B, IL10, ESR2, SH2D1A
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.2AR, IL1B, IL10, ESR1

Molecular functions related to Vaginitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:0340569.7ESR1, ESR2
2estrogen receptor activityGO:0302849.7ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:0010469.7ESR1, ESR2
4steroid bindingGO:0054969.6ESR1, ESR2
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5AR, ESR2
6beta-catenin bindingGO:0080139.5AR, ESR1
7steroid hormone receptor activityGO:0037079.2ESR1, ESR2
8enzyme bindingGO:0198999.1ESR2, ESR1, AR

Products for genes affiliated with Vaginitis

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Sources for Vaginitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet