MCID: VRC001
MIFTS: 51

Varicocele malady

Cardiovascular diseases category

Summaries for Varicocele

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63Wikipedia, 32MalaCards
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Wikipedia:63 Varicocele /ˈværɨkɵsiːl/ is an abnormal enlargement of the pampiniform venous plexus in the... more...

MalaCards: Varicocele, also known as scrotal varices, is related to infertility and male infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Glycoprotein hormones and Nongenotropic Androgen signaling. The compounds estrogen and 11 deoxycortisol have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Varicocele

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

varicocele 8 10 44 60
scrotal varices 8


External Ids:

Disease Ontology8 DOID:12337
ICD9CM27 456.4
MeSH34 D014646
ICD1025 I86.1

Related Diseases for Varicocele

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17GeneCards, 18GeneDecks
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Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.3SHBG, AZF1, GNRH1, USP9Y, CGA, PRL
2male infertility30.8ACR, SHBG, PRL, GNRH1, HSPA2
3azoospermia30.7ACPP, GNRH1, AMH, AZF1, USP9Y, SHBG
4prostatitis30.5ACPP
5oligospermia30.4AZF1, AMH, GNRH1, USP9Y, CGA, CGB5
6cryptorchidism30.2CGB5, CGA, SHBG, AZF1, AMH, GNRH1
7gynecomastia30.0PRL, GNRH1, CGA, CGB5, SHBG
8impotence30.0SHBG, PRL
9klinefelter's syndrome29.8AZF1, GNRH1, CGA, PRL, SHBG
10ischemia29.8BLVRB
11hypogonadism29.8CGA, SHBG, PRL, CGB5, GNRH1
12hydrocele10.3
13ankylosing spondylitis10.0
14angiokeratoma of fordyce10.0
15angiokeratoma10.0
16constipation10.0
17hepatitis10.0
18nephrotic syndrome10.0
19renal cell carcinoma10.0
20spondylitis10.0
21turner syndrome10.0GNRH1
22diabetes insipidus10.0PRL
23insulin resistance10.0SHBG
24systemic lupus erythematosus10.0PRL
25hermaphroditism10.0AMH
26obesity10.0SHBG
27hypogonadotropism10.0GNRH1, PRL
28peritonitis10.0AQP1
29mccune albright syndrome10.0GNRH1
30cushing's syndrome10.0PRL
31prostatic hypertrophy10.0GNRH1, ACPP
32thyroiditis10.0CGA
33pseudohermaphroditism10.0AMH
34seminoma10.0CGA, CGB5
35penile disease10.0GNRH1, PRL
36hypothalamic disease10.0GNRH1, PRL, CGA
37sexual disorder10.0SHBG, PRL, GNRH1
38germinoma10.0CGB5, CGA
39prolactinoma10.0GNRH1, PRL, CGA
40teratoma10.0CGB5, CGA
41ovarian hyperstimulation syndrome10.0GNRH1, CGA, CGB5
42premature ovarian failure10.0GNRH1, SHBG, PRL
43dysgerminoma10.0CGA, CGB5
44abrikosov's tumor10.0AMH, GNRH1, CGA
45ovarian cyst10.0CGB5, CGA, GNRH1
46leydig cell tumor10.0GNRH1, CGA, CGB5
47hypogonadism, hypergonadotropic10.0PRL, SHBG
48acromegaly10.0PRL, SHBG, GNRH1
49ovarian disease10.0SHBG, GNRH1, PRL, CGA
50pregnancy loss10.0CGA, CGB5, GNRH1

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Clinical Features for Varicocele

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Drugs & Therapeutics for Varicocele

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Varicocele

Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Search CenterWatch for Varicocele

Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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32MalaCards
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MalaCards organs/tissues related to Varicocele:

32
Testis, Testes, Prostate, Kidney, Endothelial, Smooth muscle, Pituitary, Colon, Spinal cord, Brain

Animal Models for Varicocele or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Varicocele:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8HSF2, AMH, GNRH1, CGA, PRL, INHBB
2MP:00053899.4AQP1, HSPA2, HSF2, AMH, GNRH1, CGA

Publications for Varicocele

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50PubMed
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Articles related to Varicocele:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Is there any relationship between mean platelet volume and varicocele? (24387241)
2014
2
Human sperm anatomy and endocrinology in varicocele: role of androgen receptor. (24429393)
2014
3
Varicocele and value based health care. (23485504)
2013
4
Current issues in varicocele management: a review. (23658861)
2013
5
Elevation of testicular temperature predicts testicular catch-up growth and hypotrophy after varicocelectomy and observation in adolescent varicocele. (23523290)
2013
6
Seminal androgens, oestradiol and progesterone in oligoasthenoteratozoospermic men with varicocele. (23944757)
2013
7
Differential spermatozoal protein expression profiles in men with varicocele compared to control subjects: upregulation of heat shock proteins 70 and 90 in varicocele. (23540861)
2013
8
Regarding: "Pediatrics varicocele surgery: 10 years of experience in two pediatric surgical centers". (23259575)
2013
9
Polyorchidism with varicocele: a case report and review of literature. (21972790)
2012
10
Effect of varicocele on sperm function and semen oxidative stress. (21592296)
2012
11
Abnormalities of the testes and semen parameters in clinical varicocele. (22543118)
2012
12
Varicocele surgery or embolization: Which is better? (23093537)
2012
13
Effects of anthocyanin extracted from black soybean seed coat on spermatogenesis in a rat varicocele-induced model. (22697115)
2012
14
Re: Bozkurt et al.: relationship between mean platelet volume and varicocele: a preliminary study (Urology 2012:79:1048-1051). (22925260)
2012
15
Expression of E-cadherin and I+-catenin in a varicocele-induced infertility rat model. (21399649)
2011
16
Chronic constipation: facilitator factor for development of varicocele. (21677833)
2011
17
Varicocele-induced infertility: Newer insights into its pathophysiology. (21716891)
2011
18
Comparison of spermatic vein histology in patients with and without varicocele. (21951199)
2011
19
Re: Sperm chromatin condensation in infertile men with varicocele before and after surgical repair. (21993123)
2011
20
Presence of the brain proteins cerebral cavernous malformation-2 and cerebral cavernous malformation-3 in rat testes and their potential role in experimental varicocele. (19647235)
2010
21
Analysis of azoospermia factor loci polymorphisms among Tunisian infertile men with varicocele. (20818979)
2010
22
Flow cytometric evaluation of sperm superoxide anion production in rats with experimental varicocele. (19616831)
2010
23
Varicocele repair for treatment of androgen deficiency. (20852425)
2010
24
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
25
Current management of the adolescent varicocele. (19239820)
2009
26
Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. (18772487)
2009
27
Male varicocele: transcatheter foam sclerotherapy with sodium tetradecyl sulfate--outcome in 244 patients. (18227549)
2008
28
Relationship between testicular volume and varicocele in patients with infertility. (18242375)
2008
29
May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? (17982752)
2008
30
Retrograde percutaneous sclerotherapy of left idiopathic varicocele in children: results and follow-up. (18365215)
2008
31
The treatment of adolescents presenting with a varicocele. (17822454)
2007
32
Significance of sperm characteristics in the evaluation of adolescents, adults and older men with varicocele. (17244963)
2007
33
Altered serum inhibin b levels in adolescents with varicocele. (17270555)
2007
34
The analgesic efficacy of preoperative versus postoperative lornoxicam in varicocele repair. (18083471)
2007
35
Intratesticular varicocele and extratesticular varicocele in a patient with nephrotic syndrome complicated by left renal vein thrombosis. (16861853)
2006
36
Reactive oxygen species and antioxidants relationship in the internal spermatic vein blood of infertile men with varicocele. (16763721)
2006
37
A rare case of right varicocele testis caused by a renal cell carcinoma thrombus in the spermatic vein. (16834679)
2006
38
Screening for Y chromosome microdeletions in idiopathic and nonidiopathic infertile men with varicocele and cryptorchidism. (16157049)
2005
39
Incidence and management of hydrocele following varicocele surgery in children. (14767329)
2004
40
Study of varicocele and oxidative stress]. (15148919)
2004
41
Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele. (11870126)
2002
42
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
43
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
44
Serum inhibin B levels and the response to gonadotropin stimulation test in pubertal boys with varicocele. (10458399)
1999
45
Leydig cell function in experimental cryptorchism and varicocele in rats]. (10390949)
1999
46
Hypothalamic-pituitary-gonadal damage in adolescents with varicocele]. (8935565)
1996
47
Correlation of testicular volume, histology and LHRH test in adolescents with idiopathic varicocele. (7925532)
1994
48
Lack of association between varicocele and angiokeratoma of the scrotum (Fordyce). (7816227)
1994
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Retroperitoneal Sarcoma Causing Varicocele. (19992345)
1941

Genetic Variations for Varicocele

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Expression for genes affiliated with Varicocele

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Varicocele according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GNRH1, CGA
210.3SHBG, GNRH1
3
Hide members
10.3HMOX2, BLVRB
4
Hide members
10.3HMOX2, BLVRB
510.3BLVRB, ACPP

Compounds for genes affiliated with Varicocele

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7HSF2, ACPP
211 deoxycortisol4410.6SHBG, CGA, PRL
3estradiol benzoate4410.6CGB5, GNRH1, PRL, CGA
4leuprolide44 59 28 1113.6GNRH1, PRL, CGB5, CGA
5goserelin44 28 1112.6ACPP, GNRH1, SHBG, CGA
6metoclopramide44 1111.6GNRH1, PRL, CGA
7cyproteroneacetate4410.6GNRH1, PRL, SHBG, ACPP
8bromocriptine28 44 1112.6GNRH1, CGA, SHBG, PRL
9flutamide44 59 1112.6SHBG, GNRH1, CGA, ACPP, PRL
1017-hydroxypregnenolone4410.6SHBG, CGB5, CGA, ACPP
11toremifene44 1111.5SHBG, PRL, GNRH1
12leuprolide acetate4410.5GNRH1, CGA, CGB5, PRL, SHBG
13cetrorelix44 28 1112.5CGB5, CGA, GNRH1
14clomiphene citrate4410.5PRL, CGB5, CGA, GNRH1, SHBG
15buserelin44 28 1112.5ACPP, CGB5, PRL, CGA, GNRH1
16dopamine44 28 11 2413.5BLVRB, HMOX2, GNRH1, SHBG
17naloxone44 49 28 1113.5GNRH1, CGB5, PRL, CGA
18danazol44 11 2412.5GNRH1, SHBG, PRL
19altrenogest4410.5CGA, GNRH1
20percoll4410.5ACR, CGB5, CGA, LDHC
21cabergoline28 44 1112.5PRL, GNRH1, CGA
22progestin4410.5CGB5, GNRH1, PRL, SHBG, CGA
23diethylstilbestrol44 28 1112.5GNRH1, CGB5, SHBG, ACPP, CGA
2417-hydroxyprogesterone44 2411.5SHBG, GNRH1, ACPP, CGA, CGB5, PRL
25dehydroepiandrosterone sulfate4410.5CGB5, PRL, CGA, GNRH1, ACPP, SHBG
26mifepristone44 59 28 1113.5AMH, GNRH1, CGA, CGB5, PRL, SHBG
27dhea4410.5ACPP, CGB5, PRL, SHBG
28androstenedione44 2411.5CGB5, GNRH1, PRL, CGA, ACPP, SHBG
29gnrh4410.4BLVRB, INHBB, ACPP, CGA, GNRH1, SHBG
3011-ketotestosterone4410.4CGA, CGB5
31metrodin4410.4CGA, GNRH1
32estrone44 28 11 2413.4GNRH1, CGB5, PRL, SHBG
33dihydrotestosterone44 28 11 2413.4CGA, ACPP, CGB5, GNRH1, PRL, SHBG
34sodium nitroprusside4410.4AQP1, GNRH1, CGA, BLVRB, CGB5
35acth4410.4PRL, ACPP, SHBG, CGB5, GNRH1
36epinephrine44 11 2412.4GNRH1, CGB5, PRL, SHBG, CGA
37tamoxifen44 49 28 1113.4SHBG, PRL, CGA, CGB5, AMH, GNRH1
38ribonucleic acid4410.4GNRH1, CGA, CGB5, PRL, HMOX2
39deslorelin4410.4GNRH1, CGA
40estradiol44 11 2412.3ACPP, BLVRB, SHBG, PRL, CGB5, CGA
41pergonal4410.3CGA, GNRH1
42lactate4410.2GNRH1, LDHC, ACR, ACPP, CGA, GLA
43creatinine4410.2AQP1, LDHC, ACPP, GLA, SHBG, CGB5
44steroid4410.2SHBG, GNRH1, CGB5, CGA, BLVRB, ACPP
45progesterone44 59 28 11 2414.2BLVRB, HMOX2, ACPP, CGB5, SHBG, PRL
46adenylate4410.2BLVRB, CGA, CGB5, SHBG, NT5E, GNRH1
47testosterone44 59 11 2413.2CGB5, LDHC, ACPP, CGA, BLVRB, SHBG
48norepinephrine44 11 2412.1GNRH1, CGA, CGB5, SHBG, PRL
49arginine4410.0SHBG, ACR, ACPP, HMOX2, GLA, BLVRB
50(+-)-pgf2-alpha449.9GNRH1, CGA, CGB5

GO Terms for genes affiliated with Varicocele

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16Gene Ontology
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Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8ACR, ACPP, INHBB, GLA, SHBG, PRL

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.3HMOX2, BLVRB
2heme catabolic processGO:04216710.2HMOX2, BLVRB
3ovulation cycleGO:04269810.0PRL, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.1SHBG, GLA, INHBB, ACPP, HSF2
2hormone activityGO:0051799.8INHBB, PRL, CGA, GNRH1, AMH

Products for genes affiliated with Varicocele

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  • Antibodies
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Sources for Varicocele

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet