Aliases & Classifications for Varicocele

About this section

Aliases & Descriptions for Varicocele:

Name: Varicocele 10 47 12 36 65
 
Scrotal Varices 10

Classifications:



External Ids:

Disease Ontology10 DOID:12337
ICD1027 I86.1
ICD9CM29 456.4
MeSH36 D014646
UMLS65 C0042341

Summaries for Varicocele

About this section
Wikipedia:68 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to arteriovenous malformation and hypogonadism, and has symptoms including swelling of scrotumand pain in scrotum. An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways are Naphthalene metabolism and Hormone ligand-binding receptors. Affiliated tissues include testis, prostate and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Varicocele

About this section

Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1arteriovenous malformation30.5GNRH1, PRL
2hypogonadism30.1AMH, GNRH1, PRL
3infertility10.7
4cercarial dermatitis10.7GNRH1, PRL
5cranial nerve disease10.7GNRH1, PRL
6enterobiasis10.7GNRH1, PRL
7dysostosis10.7GNRH1, PRL
8penoscrotal transposition10.6CGA, GNRH1
9hematocele of tunica vaginalis testis10.6GNRH1, PRL
10prostatocystitis10.6GNRH1, PRL
11zap70-related severe combined immunodeficiency10.6AZF1, PRL
12epididymal neoplasm10.6GNRH1, PRL
13uremic neuropathy10.6AMH, GNRH1
14external ear disease10.5CGA, GNRH1, PRL
15perianal hematoma10.5GNRH1, PRL
16setariasis10.5AMH, GNRH1
17lipoadenoma10.4PRL, TP53
18scleromalacia perforans10.4GSTM1, GSTT1, PRL
19hidradenitis suppurativa10.4AMH, GNRH1, PRL
20dowling-degos disease10.4CGA, GNRH1
21nodular episcleritis10.3GNRH1, PRL
22urethra inverted papilloma10.3PARP1, TP53
23male infertility10.3
24azoospermia10.3
25pituitary adenoma10.3GNRH1, PRL, TP53
26prostatitis10.2
27mutiple parosteal osteochondromatous proliferations10.2GSTM1, GSTT1, TP53
28hypoxia10.2
29anorectal stricture10.2AMH, CGA, GNRH1, PRL
30mucinous cystadenocarcinoma10.1CASP3, GSTM1, GSTT1
31periocular meningioma10.1GSTM1, GSTT1, TP53
32leprechaunism10.1AMH, AZF1, CGA, GNRH1
33cardiovascular organ benign neoplasm10.1PRL, TP53
34atrial heart septal defect10.1ALB, GNRH1, PRL
35sex differentiation disease10.1AMH, AZF1, GNRH1, PRL
36acute monocytic leukemia10.1GSTM1, GSTT1, TP53
37juxtacortical chondroma10.1GSTM1, GSTT1, TP53
38oligospermia10.1
39hydrocele10.1
40endotheliitis10.0
41peritoneal serous papillary adenocarcinoma10.0ALB, TP53
42large cell medulloblastoma10.0CASP3, GNRH1, TP53
43integumentary system benign neoplasm9.9CASP3, GSTM1, TP53
44filamentary keratitis9.9GSTM1, GSTT1
45placental insufficiency9.9GSTM1, GSTT1, TP53
46cryptorchidism9.9
47inguinal hernia9.9
48hepatocellular adenoma9.9CASP3, HIF1A, TP53
49baritosis9.9GSTM1, GSTT1, IL6
50renal cell carcinoma9.8

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

About this section

UMLS symptoms related to Varicocele:


swelling of scrotum, pain in scrotum

Drugs & Therapeutics for Varicocele

About this section

Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ginsengapproved, nutraceuticalPhase 48750647-08-0
2
methylene bluePhase 271
Synonyms:
Urolene Blue
aniline violet
 
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
Vitamin Eapproved, nutraceutical37159-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Hormones11748
5Androgens1162
6Follicle Stimulating Hormone151
7Hormones, Hormone Substitutes, and Hormone Antagonists9988
8Estrogens2144
9Hormone Antagonists10002
10Vitamins3857
11Tocopherols376
12Tocotrienols372
13TocopherolNutraceutical376
14TocotrienolNutraceutical372

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3The Role of Microsurgery in Surgical Treatment of Varicocele.RecruitingNCT02722187Phase 4
4Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele SurgeryNot yet recruitingNCT02719093Phase 4
5Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
6Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
7Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
8The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
9Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
10Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
11Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
12Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
13Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
14Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaRecruitingNCT02306499
15The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
16Doppler Ultrasound Assisted Varicocelectomy Improve Sperm QualitiesRecruitingNCT02695199
17Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
18The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
19Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
20Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenActive, not recruitingNCT00150163
21Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
22Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
23Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

About this section

Anatomical Context for Varicocele

About this section

MalaCards organs/tissues related to Varicocele:

33
Testis, Prostate, Testes, Brain, Thyroid, Endothelial, Kidney

Animal Models for Varicocele or affiliated genes

About this section

MGI Mouse Phenotypes related to Varicocele:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3ALB, GNRH1, HIF1A, IL6, PRL, TP53
2MP:00020067.9ALB, AMH, GNRH1, HIF1A, IL6, PRL
3MP:00053817.7ALB, CASP3, GNRH1, HIF1A, IL6, TP53
4MP:00107717.4CASP3, GNRH1, HIF1A, IL6, PARP1, PRL
5MP:00053796.7ALB, AMH, CASP3, CGA, GNRH1, HIF1A
6MP:00053676.7ALB, CASP3, GNRH1, HIF1A, IL6, PARP1
7MP:00053896.5AMH, CASP3, CGA, GNRH1, HSPA2, IL6
8MP:00053766.0ALB, AMH, CASP3, CGA, GNRH1, HIF1A

Publications for Varicocele

About this section

Articles related to Varicocele:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Comparison of the Effects of Varicocelectomy and Oral L-carnitine on Sperm Parameters in Infertile Men with Varicocele. (27190879)
2016
2
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
3
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
4
Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study. (25405715)
2014
5
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele. (25179750)
2014
6
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
7
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
8
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
9
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
10
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
11
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
12
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
13
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
14
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
15
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
16
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
17
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
18
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
19
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
20
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
21
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
22
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
23
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
24
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
25
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
26
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
27
Testicular varicocele: an overview. (19506401)
2009
28
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
29
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
30
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
31
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
32
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
33
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
34
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
35
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
36
The treatment of adolescents presenting with a varicocele. (17822454)
2007
37
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
38
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
39
Antisperm antibodies and varicocele. (16466113)
2006
40
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
41
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
42
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
43
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
44
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
45
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
46
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
47
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
48
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

About this section

Expression for genes affiliated with Varicocele

About this section
Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

About this section

GO Terms for genes affiliated with Varicocele

About this section

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glutathione metabolic processGO:000674910.2GSTM1, GSTT1
2muscle cell cellular homeostasisGO:004671610.1HIF1A, IL6
3response to coldGO:000940910.0HSPA2, IL6
4response to auditory stimulusGO:001099610.0HIF1A, IL6
5response to glucocorticoidGO:00513849.6CASP3, HIF1A, IL6
6response to antibioticGO:00466779.5CASP3, IL6, TP53
7response to lipopolysaccharideGO:00324969.1CASP3, GNRH1, IL6
8cellular response to DNA damage stimulusGO:00069748.9CASP3, PARP1, TP53
9response to organic cyclic compoundGO:00140708.8AMH, CASP3, IL6
10positive regulation of gene expressionGO:00106288.7AMH, HIF1A, IL6, TP53
11negative regulation of apoptotic processGO:00430668.1ALB, CASP3, GNRH1, HIF1A, IL6, TP53
12positive regulation of transcription from RNA polymerase II promoterGO:00459447.8CGA, HIF1A, IL6, PARP1, TP53

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.4ALB, TP53

Sources for Varicocele

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet