Aliases & Classifications for Varicocele

MalaCards integrated aliases for Varicocele:

Name: Varicocele 12 29 52 42 14 69
Scrotal Varices 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12337
ICD10 33 I86.1
ICD9CM 35 456.4
MeSH 42 D014646
UMLS 69 C0042341

Summaries for Varicocele

MalaCards based summary : Varicocele, also known as scrotal varices, is related to retroperitoneal sarcoma and african histoplasmosis, and has symptoms including pain in scrotum An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Pathways in cancer. The drugs Ginseng and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

Related Diseases for Varicocele

Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
id Related Disease Score Top Affiliating Genes
1 retroperitoneal sarcoma 22.3 AMH AZF1 CASP3 CASP9 CGA GNRH1
2 african histoplasmosis 10.8 GNRH1 PRL
3 prostate leiomyoma 10.8 GNRH1 PRL
4 adenomatoid tumor 10.8 GNRH1 PRL
5 intermittent squint 10.7 GNRH1 PRL
6 lymphoepithelioma-like carcinoma 10.7 GNRH1 PRL
7 vertebral artery occlusion 10.7 GNRH1 PRL
8 pepck 1 deficiency 10.7 CGA GNRH1
9 asbestos intoxication 10.7 GSTM1 GSTT1
10 lactic acidosis 10.6 GNRH1 PRL
11 hole retinal cyst 10.6 GNRH1 HIF1A
12 infertility 10.6
13 endometriosis 10.6 PRL SHBG
14 vaginal discharge 10.6 CGA SHBG
15 internal hemorrhoid 10.5 GNRH1 PRL SHBG
16 gastrointestinal tularemia 10.5 GSTM1 GSTT1 PRL
17 orbital lymphoma 10.5 GSTM1 GSTT1
18 capillary disease 10.5 CGA PRL SHBG
19 uterine corpus adenocarcinofibroma 10.5 GNRH1 PRL SHBG
20 pelvic muscle wasting 10.5 GNRH1 PRL SHBG
21 acute gonococcal salpingitis 10.5 GNRH1 PRL SHBG
22 skin meningioma 10.4 CGA PRL SHBG
23 acute pancreatitis 10.4 GNRH1 GSTM1 GSTT1
24 nipple neoplasm 10.4 AZF1 CGA SHBG
25 precursor b lymphoblastic lymphoma/leukemia 10.4 GNRH1 PRL SHBG
26 thymus mucoepidermoid carcinoma 10.4 AMH GNRH1
27 ovarian cystadenocarcinoma 10.3 CASP3 GSTM1 GSTT1
28 orbital lymphangioma 10.3 CASP3 GSTM1 GSTT1
29 cytomegalovirus infection 10.3 CASP3 CASP9
30 medullomyoblastoma 10.3 CASP3 GNRH1 SHBG
31 xanthogranulomatous cholecystitis 10.3 CASP3 NOS2
32 porokeratosis 10.3 CGA GNRH1 PRL SHBG
33 hepatocellular adenoma 10.2 GSTM1 GSTT1 NOS3
34 joint disorders 10.2 GSTM1 GSTT1 NOS3
35 contagious pustular dermatitis 10.2 CGA SHBG
36 munchausen by proxy 10.2 NOS3 PRL SHBG
37 ovarian hyperstimulation syndrome 10.2 AMH CGA GNRH1
38 male infertility 10.2
39 survival motor neuron spinal muscular atrophy 10.2 NOS3 PRL SHBG
40 azoospermia 10.1
41 splenic disease 10.1 CASP3 CGA NOS3
42 tracheal lymphoma 10.1 CASP3 NOS3
43 psychologic vaginismus 10.1 NOS2 NOS3
44 lethal congenital contractural syndrome 2 10.1 CASP9 NOS3
45 ladd syndrome 10.1 CASP3 CASP9 HIF1A
46 capillary lymphangioma 10.1 AMH GNRH1 SHBG
47 prostatitis 10.1
48 zimmermann-laband syndrome 2 10.0 GSTM1 GSTT1 HIF1A
49 hypoxia 10.0
50 hartnup disorder 10.0 CASP3 CASP9 HIF1A

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to Varicocele

Symptoms & Phenotypes for Varicocele

UMLS symptoms related to Varicocele:


pain in scrotum

MGI Mouse Phenotypes related to Varicocele:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 AMH CASP3 CASP9 CGA GNRH1 HIF1A
2 reproductive system MP:0005389 9.23 HSPA2 NOS2 NOS3 PRL AMH CASP3

Drugs & Therapeutics for Varicocele

Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
2
Methylene blue Investigational Phase 2 61-73-4
3
Sodium Tetradecyl Sulfate Approved 1191-50-0, 139-88-8 14492 5248
4 Tocopherol Approved, Nutraceutical
5
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
6 Androgens
7 Estrogens
8 Hormone Antagonists
9 Hormones
10 Hormones, Hormone Substitutes, and Hormone Antagonists
11 Analgesics
12 Anesthetics
13 Anesthetics, Local
14 Anti-Infective Agents, Local
15 Central Nervous System Depressants
16 Follicle Stimulating Hormone
17 Vaccines
18 Tocopherols
19 Tocotrienols
20 Vitamins
21 Tocotrienol Investigational, Nutraceutical 6829-55-6

Interventional clinical trials:

(show all 28)

id Name Status NCT ID Phase Drugs
1 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
2 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4 Korean Red Ginseng, Varicocelectomy;Placebo
3 The Role of Microsurgery in Surgical Treatment of Varicocele. Recruiting NCT02722187 Phase 4
4 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Not yet recruiting NCT02719093 Phase 4 recombinant FSH
5 Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis Terminated NCT00767338 Phase 3
6 Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy Completed NCT01259258 Phase 2
7 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
8 The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analisy Unknown status NCT02401087
9 Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE Unknown status NCT02033863
10 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
11 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
12 The Effect of Spermatic Vein Embolization on Prostatic Hypertrophy Completed NCT00639899
13 Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility Completed NCT02006316
14 Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate Cancer Completed NCT00637208
15 Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy Completed NCT02092311
16 Single Incision Laparoscopic Varicocelectomy Completed NCT02335385
17 Varicocelectomy To Treat Pain, Predictors Of Success Completed NCT01395186
18 Effect of TAP Block for Postoperative Pain Control After Varicocele Operations. Recruiting NCT02983383
19 The Search for Viral and Bacterial Etiology of Varicocele Recruiting NCT03079609
20 Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities Recruiting NCT02695199
21 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
22 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548
23 Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine Active, not recruiting NCT02983656
24 Oxidative Stress and Lipidomics in Male Infertility Active, not recruiting NCT02062229
25 IVF Outcomes After Varicocele Repair Not yet recruiting NCT03090438
26 the Effect of Different Modialites of Varicocelectomy on Semen Parameters in Patient With Normal Semen Analysis Not yet recruiting NCT03281915
27 Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy Terminated NCT00961558
28 Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality? Terminated NCT01296230

Search NIH Clinical Center for Varicocele

Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

Genetic tests related to Varicocele:

id Genetic test Affiliating Genes
1 Varicocele 29

Anatomical Context for Varicocele

MalaCards organs/tissues related to Varicocele:

39
Testis, Testes, Prostate, Endothelial, Kidney, Smooth Muscle, Pituitary

Publications for Varicocele

Articles related to Varicocele:

(show top 50) (show all 683)
id Title Authors Year
1
Back pain after varicocele embolization. ( 28678015 )
2017
2
Treatment of varicocele in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. ( 28851509 )
2017
3
Re: Sperm Concentration and Forward Motility are Not Correlated with Age inA Adolescents with an Idiopathic Varicocele and Symmetrical Testicular Volumes. ( 28817895 )
2017
4
Microsurgical varicocelectomy for clinical varicocele: A review for potential new indications. ( 28671268 )
2017
5
Update on the novel management and future paternity situation in adolescents with varicocele. ( 28861292 )
2017
6
Varicocele and male infertility. ( 28675168 )
2017
7
Varicocele ( 28846314 )
2017
8
Obstructive azoospermia caused by low ligation of varicocele: A case report. ( 28771041 )
2017
9
The intriguing role of VEGF in varicocele. ( 28741722 )
2017
10
Varicocele and semen quality: a retrospective case-control study of 4230 patients from a single centre. ( 28647897 )
2017
11
Two decades of experience with laparoscopic varicocele repair in children: Standardizing the technique. ( 28807743 )
2017
12
Studies on Varicocele and Subfertility - an Ongoing Debate. ( 28657387 )
2017
13
Re: Increased Body Mass Index in Men with Varicocele is Associated with Larger Spermatic Vein Diameters when Supine. ( 27979554 )
2017
14
Left-Sided Varicocele as a Rare Presentation of May-Thurner Syndrome. ( 28258018 )
2017
15
Therapeutic efficacy and safety of laparoscopic surgery versus microsurgery for varicocele of adult males: A meta-analysis. ( 28834886 )
2017
16
The varicocele as related to fertility. ( 27842996 )
2017
17
Pressure flow pattern of varicocele veins and its correlation with testicular blood flow and semen parameters. ( 28766734 )
2017
18
The Role of Varicocele in Male Factor Subfertility. ( 28718159 )
2017
19
Unilateral angiokeratoma of the scrotum (Fordyce's type) associated with a contralateral varicocele. ( 28540880 )
2017
20
Autophagy may play an important role in varicocele. ( 28849201 )
2017
21
Back pain after varicocele embolization. ( 28678016 )
2017
22
A review of varicocele repair for pain. ( 28725614 )
2017
23
Comparative Expression Analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor Gene between Varicocele-Induced and Non-Varicocele Testes of Dog. ( 28868836 )
2017
24
Randomised clinical trial of comparing effects of acupuncture and varicocelectomy on sperm parameters in infertile varicocele patients. ( 28083932 )
2017
25
Roles of Fas/FasL-mediated apoptosis and inhibin B in the testicular dysfunction of rats with left-side varicocele. ( 28722192 )
2017
26
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. ( 27595632 )
2016
27
Varicocele in a Young Man: Something We Should Be Worried About? ( 27481181 )
2016
28
Varicocele: tissue stress in the etiology. ( 27513398 )
2016
29
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. ( 27423503 )
2016
30
Diagnosis and Management of Pediatric and Adolescent Varicocele: A Survey of Pediatric Urologists in Korea. ( 27689031 )
2016
31
Testosterone and Varicocele. ( 27132580 )
2016
32
Who will benefit from surgical repair for painful varicocele: a meta-analysis. ( 27074742 )
2016
33
Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele. ( 28105423 )
2016
34
Prognostic Predictors of Fertility in Young Adult Patients With Varicocele: Peak Retrograde Flow Velocity and Reflux Grade. ( 27151907 )
2016
35
Evaluation of enzymatic and non-enzymatic antioxidants in seminal plasma of men with genitourinary infections, varicocele and idiopathic infertility. ( 27027567 )
2016
36
The Role of Sonoelastography in the Evaluation of Testes With Varicocele. ( 27521065 )
2016
37
The Relationship Between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele. ( 26866567 )
2016
38
Tracing of zinc and iron in experimentally induced varicocele: correlation with oxidative, nitrosative and carbonyl stress. ( 27682184 )
2016
39
Retroperitoneal paraganglioma presenting as right-sided varicocele: case report. ( 26997533 )
2016
40
Neck or groin access for varicocele embolisation: Is it important? ( 27396460 )
2016
41
Varicocele among infertile men in Qatar. ( 27401026 )
2016
42
Association between clinical and ultrasonic characteristics of varicocele and lower extremity varicose vein in men. ( 27531086 )
2016
43
Comparison of the Effects of Varicocelectomy and Oral L-carnitine on Sperm Parameters in Infertile Men with Varicocele. ( 27190879 )
2016
44
EP27.10: Ultrasound diagnosis of thrombi in pelvic varicocele. ( 27647558 )
2016
45
Steroid receptors in human ejaculated sperm as molecular markers of the detrimental effects related to the pathophysiology of testicular varicocele. ( 27031584 )
2016
46
First report of a spermatic granuloma and varicocele in a marsupial: A Koala (Phascolarctos cinereus) Case Study. ( 27473971 )
2016
47
Varicocele: A Review. ( 27582603 )
2016
48
Venous Blood Gases of Varicocele Veins: Correlation With Testicular Blood Flow and Semen Quality in Varicocele Patients. ( 27424121 )
2016
49
Risk of varicocele in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic disease: a population-based case-control study. ( 27973977 )
2016
50
Alterations in the proliferative/apoptotic equilibrium in semen of adolescents with varicocele. ( 27629121 )
2016

Variations for Varicocele

Expression for Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for Varicocele

Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CASP3 CASP9 CGA GNRH1
2 12.47 CASP3 CASP9 HIF1A NOS2
3
Show member pathways
12.11 CASP3 CGA NOS2 NOS3 PRL
4 11.89 GSTM1 GSTT1 NOS3
5
Show member pathways
11.89 CASP3 CASP9 HSPA2 NOS2
6
Show member pathways
11.88 CASP3 CASP9 PLCZ1
7 11.79 CASP9 HIF1A PLCZ1
8 11.77 CASP3 CASP9 PLCZ1
9 11.71 HIF1A NOS2 NOS3
10 11.64 CASP3 CASP9 NOS3
11 11.58 CASP3 CASP9 NOS2
12
Show member pathways
11.55 CASP3 CASP9 NOS3
13
Show member pathways
11.35 HSPA2 NOS2 NOS3
14 11.32 CASP3 CASP9 GSTM1 GSTT1
15 11.28 CASP3 CASP9 HSPA2
16 10.99 HIF1A NOS3
17 10.98 NOS2 NOS3
18 10.97 GSTM1 GSTT1
19 10.96 CASP3 CASP9 HIF1A NOS2
20 10.95 CASP3 CASP9
21 10.84 CASP3 CASP9 HIF1A NOS2 NOS3
22 10.81 GNRH1 SHBG
23 10.64 CGA GNRH1
24 10.62 NOS2 NOS3
25 10.34 NOS2 NOS3

GO Terms for Varicocele

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 glutathione derivative biosynthetic process GO:1901687 9.51 GSTM1 GSTT1
2 platelet formation GO:0030220 9.49 CASP3 CASP9
3 nitric oxide mediated signal transduction GO:0007263 9.48 NOS2 NOS3
4 nitric oxide biosynthetic process GO:0006809 9.46 NOS2 NOS3
5 response to lipopolysaccharide GO:0032496 9.46 CASP3 CASP9 GNRH1 NOS2
6 gonad development GO:0008406 9.43 AMH CGA
7 positive regulation of guanylate cyclase activity GO:0031284 9.4 NOS2 NOS3
8 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.37 CASP3 CASP9
9 arginine catabolic process GO:0006527 9.32 NOS2 NOS3
10 response to cobalt ion GO:0032025 9.26 CASP3 CASP9
11 glial cell apoptotic process GO:0034349 8.96 CASP3 CASP9
12 response to organic cyclic compound GO:0014070 8.92 AMH CASP3 CASP9 GNRH1

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 FMN binding GO:0010181 9.4 NOS2 NOS3
2 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP3 CASP9
3 arginine binding GO:0034618 9.32 NOS2 NOS3
4 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS2 NOS3
5 tetrahydrobiopterin binding GO:0034617 9.16 NOS2 NOS3
6 nitric-oxide synthase activity GO:0004517 8.96 NOS2 NOS3
7 hormone activity GO:0005179 8.92 AMH CGA GNRH1 PRL

Sources for Varicocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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