Aliases & Classifications for Varicocele

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Aliases & Descriptions for Varicocele:

Name: Varicocele 11 13 25 48 37 66
 
Scrotal Varices 11

Classifications:



External Ids:

Disease Ontology11 DOID:12337
ICD1028 I86.1
ICD9CM30 456.4
MeSH37 D014646

Summaries for Varicocele

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Wikipedia:69 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to hypogonadism and obesity, and has symptoms including pain in scrotum and swelling of scrotum. An important gene associated with Varicocele is PRL (Prolactin), and among its related pathways are Nongenotropic Androgen signaling and Naphthalene metabolism. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are neoplasm and liver/biliary system.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism30.1AMH, PRL, SHBG
2obesity27.6ALB, IL6, NOS3, PRL, SHBG
3mobitz type ii atrioventricular block10.7GNRH1, PRL
4benign prostate phyllodes tumor10.7GNRH1, PRL
5infertility10.7
6lipid-rich carcinoma10.7GNRH1, PRL
7retinal microaneurysm10.7GNRH1, PRL
8hypothalamic neoplasm10.7GNRH1, PRL
9oral pharyngeal disorders10.6GSTM1, GSTT1
10riedel's fibrosing thyroiditis10.6PRL, SHBG
11hemorrhoid10.5PRL, SHBG
12orbital cyst10.5GSTM1, GSTT1, PRL
13levic stefanovic nikolic syndrome10.5GSTM1, GSTT1
14uremia10.5AMH, GNRH1
15prolactin producing pituitary tumor10.4GNRH1, PRL, SHBG
16benign paroxysmal positional nystagmus10.4GNRH1, PRL, SHBG
17chondroma10.4GSTM1, GSTT1, HIF1A
18chronic frontal sinusitis10.4AMH, GNRH1
19ovarian mucinous cystadenocarcinoma10.4CASP3, GSTM1, GSTT1
20hematocele of tunica vaginalis testis10.3ALB, SHBG
21cerebellar vermis medulloblastoma10.3CASP3, GNRH1, SHBG
22male infertility10.3
23alveolar periostitis10.3ALB, SHBG
24azoospermia10.3
25ulcerative stomatitis10.2ALB, GSTM1, GSTT1
26prostatitis10.2
27elane-related neutropenia10.2CASP9, NOS2
28diabetes mellitus, insulin-resistant, with acanthosis nigricans10.2AMH, GNRH1, SHBG
29alveoli adenoma10.2ALB, PRL, SHBG
30female reproductive organ cancer10.2CASP3, NOS3
31hypoxia10.2
32munchausen by proxy10.1NOS3, PRL, SHBG
33hepatitis c10.1NOS3, PRL, SHBG
34oligospermia10.1
35lethal congenital contractural syndrome 210.1CASP9, NOS3
36hydrocele10.1
37ovarian hyperstimulation syndrome10.1ALB, AMH, GNRH1
38angioedema10.1ALB, NOS2
39gaucher's disease10.0AMH, GNRH1, PRL, SHBG
40pleural empyema10.0AMH, GNRH1, PRL, SHBG
41dental pulp necrosis10.0AMH, GNRH1, PRL, SHBG
42hidradenitis10.0AMH, GNRH1, PRL, SHBG
43pseudopterygium10.0AMH, GNRH1, PRL, SHBG
44precursor b lymphoblastic lymphoma/leukemia10.0AMH, GNRH1, PRL, SHBG
45endotheliitis10.0
46berylliosis10.0GSTM1, GSTT1, IL6
47asbestosis9.9GSTM1, GSTT1, IL6
48amelogenesis imperfecta hypomaturation type9.9CASP3, IL6
49cryptorchidism9.9
50inguinal hernia9.9

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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UMLS symptoms related to Varicocele:


pain in scrotum, swelling of scrotum

Drugs & Therapeutics for Varicocele

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Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1GinsengNutraceuticalPhase 49050647-08-0
2
Methylene bluePhase 27761-73-4
Synonyms:
Basic Blue 9
C.I. basic blue 9
Lowacryl blue 9
Methylene blue
Methylene blue anhydrous
Methylthioninium chloride
 
Urolene Blue
aniline violet
methylenium ceruleum
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
vitamin eNutraceutical39259-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4TocopherolNutraceutical395
5TocotrienolNutraceutical391

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3The Role of Microsurgery in Surgical Treatment of Varicocele.RecruitingNCT02722187Phase 4
4Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele SurgeryNot yet recruitingNCT02719093Phase 4
5Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
6Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
7Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
8The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
9Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
10Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
11Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
12Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
13Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
14Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaRecruitingNCT02306499
15The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
16Doppler Ultrasound Assisted Varicocelectomy Improve Sperm QualitiesRecruitingNCT02695199
17Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
18The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
19Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
20Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenActive, not recruitingNCT00150163
21Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
22Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
23Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

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Genetic tests related to Varicocele:

id Genetic test Affiliating Genes
1 Varicocele25

Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

34
Testis, Testes, Prostate, Endothelial, Kidney, Smooth muscle, Pituitary

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6ALB, AMH, GNRH1, HIF1A, IL6, NOS2
2MP:00053707.6ALB, GNRH1, HIF1A, IL6, NOS2, NOS3
3MP:00053697.5ALB, CASP3, HIF1A, IL6, NOS2, NOS3
4MP:00053887.5CASP3, CASP9, HIF1A, IL6, NOS2, NOS3
5MP:00053897.2AMH, CASP3, GNRH1, HSPA2, IL6, NOS2
6MP:00053817.1ALB, CASP3, GNRH1, HIF1A, IL6, NOS2
7MP:00053677.1ALB, CASP3, GNRH1, HIF1A, IL6, NOS2
8MP:00053795.3ALB, AMH, CASP3, CASP9, GNRH1, HIF1A

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Venous Blood Gases of Varicocele Veins: Correlation With Testicular Blood Flow and Semen Quality in Varicocele Patients. (27424121)
2016
2
Neck or groin access for varicocele embolisation: Is it important? (27396460)
2016
3
Testosterone and Varicocele. (27132580)
2016
4
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. (27423503)
2016
5
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
6
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
7
Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele. (26347229)
2015
8
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
9
Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele. (25168538)
2014
10
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
11
Ultrasound-guided transversus abdominis plane block for retroperitoneal varicocele repair. Could it be an anesthesia method? (23619829)
2013
12
Varicocele and value based health care. (23485504)
2013
13
Current issues in varicocele management: a review. (23658861)
2013
14
Acute left varicocele in an adult. (23382262)
2013
15
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
16
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
17
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
18
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
19
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
20
Diagnostic testicular biopsy before varicocele repair plays a realistic and important role. (21183176)
2011
21
Percutaneous retrograde endovascular occlusion for pediatric varicocele. (21376204)
2011
22
Antegrade subinguinal sclerotization with temporary clamping of the spermatic cord: a new surgical technique for varicocele. (20452656)
2011
23
The impact of varicocele and varicocele repair on serum testosterone. (21681090)
2011
24
The comparison of two experimental rat varicocele models and their effect on sperm quality. (21293112)
2011
25
Markers of accessory sex glands function in men with varicocele, relationship with seminal parameters. (22018150)
2011
26
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
27
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
28
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
29
Does G force increase the incidence of varicocele in Air Force pilot cadets? (20173373)
2010
30
Reactive oxygen species in the internal spermatic and brachial veins of patients with varicocele-induced infertility. (20495699)
2010
31
Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis. (19655149)
2010
32
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
33
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
34
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
35
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
36
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
37
The effects of varicocele and its surgical correction on vas deferens motility. (18040696)
2008
38
Relationship between varicocele grade, vein reflux and testicular growth arrest. (18421464)
2008
39
Comment on: Anatomic and hemodynamic evaluation of renal venous flow in varicocele formation using color Doppler sonography with emphasis on renal vein entrapment syndrome (Scand J Urol Nephrol 2007; 41(1): 42-6). (18365925)
2008
40
Male varicocele: transcatheter foam sclerotherapy with sodium tetradecyl sulfate--outcome in 244 patients. (18227549)
2008
41
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
42
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
43
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
44
Antisperm antibodies and varicocele. (16466113)
2006
45
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
46
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
47
Intratesticular varicocele and extratesticular varicocele in a patient with nephrotic syndrome complicated by left renal vein thrombosis. (16861853)
2006
48
The use of isosulphan blue to identify lymphatic vessels in high retroperitoneal ligation of adolescent varicocele--avoiding postoperative hydrocele. (11298043)
2001
49
The value of the gonadotrophin-releasing hormone test as a prognostic factor in infertile patients with varicocele. (8944523)
1996
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
110.0GNRH1, SHBG
29.8GSTM1, GSTT1
3
Show member pathways
9.6HIF1A, NOS3
49.5CASP3, CASP9
5
Show member pathways
9.4NOS2, NOS3
69.4NOS2, NOS3
79.4NOS2, NOS3
8
Show member pathways
9.0HSPA2, NOS2, NOS3
98.9CASP3, CASP9, NOS3
10
Show member pathways
8.9CASP3, CASP9, NOS3
118.8CASP3, IL6, NOS2
128.8CASP3, IL6, NOS2
138.8CASP3, IL6, NOS2
148.7CASP3, CASP9, IL6
158.7CASP3, CASP9, IL6
16
Show member pathways
8.7CASP3, CASP9, HSPA2, NOS2
178.6CASP3, IL6, NOS3
188.3CASP3, CASP9, HSPA2, IL6
19
Show member pathways
8.3CASP3, CASP9, GNRH1, HSPA2, NOS3
208.3HIF1A, IL6, NOS2, NOS3
218.3CASP9, IL6, NOS3, PRL
228.3CASP3, CASP9, IL6, NOS2
238.3CASP3, CASP9, IL6, NOS2
248.2CASP3, CASP9, HIF1A, NOS2, NOS3
25
Show member pathways
8.1CASP9, IL6, NOS2, NOS3
268.0CASP3, CASP9, HIF1A, IL6, NOS2
27
Show member pathways
7.1AMH, CASP3, CASP9, IL6, NOS2, NOS3

GO Terms for genes affiliated with Varicocele

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Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:190168710.6GSTM1, GSTT1
2response to X-rayGO:001016510.3CASP3, HIF1A
3glial cell apoptotic processGO:003434910.1CASP3, CASP9
4platelet formationGO:003022010.1CASP3, CASP9
5positive regulation of guanylate cyclase activityGO:003128410.1NOS2, NOS3
6response to cobalt ionGO:003202510.1CASP3, CASP9
7positive regulation of chemokine productionGO:003272210.0HIF1A, IL6
8activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00086359.9CASP3, CASP9
9response to auditory stimulusGO:00109969.9HIF1A, IL6
10positive regulation of JAK-STAT cascadeGO:00464279.8IL6, PRL
11nitric oxide biosynthetic processGO:00068099.8NOS2, NOS3
12arginine catabolic processGO:00065279.8NOS2, NOS3
13nitric oxide mediated signal transductionGO:00072639.8NOS2, NOS3
14cellular response to organic cyclic compoundGO:00714079.7CASP3, CASP9, HIF1A
15muscle cell cellular homeostasisGO:00467169.7HIF1A, IL6
16response to glucocorticoidGO:00513849.5CASP3, HIF1A, IL6
17cellular response to lipopolysaccharideGO:00712229.4HIF1A, IL6, NOS2
18response to antibioticGO:00466779.2CASP3, CASP9, IL6
19response to estradiolGO:00323558.9CASP3, CASP9, HIF1A
20response to heatGO:00094088.9HSPA2, IL6, NOS3
21agingGO:00075688.7AMH, CASP9, GNRH1, IL6
22positive regulation of apoptotic processGO:00430658.5CASP3, CASP9, HIF1A, IL6
23response to organic cyclic compoundGO:00140708.5AMH, CASP3, CASP9, GNRH1, IL6
24cell redox homeostasisGO:00454548.5IL6, NOS2, NOS3
25response to lipopolysaccharideGO:00324968.3CASP3, CASP9, GNRH1, IL6, NOS2
26negative regulation of apoptotic processGO:00430668.2ALB, CASP3, GNRH1, HIF1A, IL6

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:000517910.0AMH, GNRH1, PRL
2nitric-oxide synthase activityGO:000451710.0NOS2, NOS3
3arginine bindingGO:003461810.0NOS2, NOS3
4cysteine-type endopeptidase activity involved in apoptotic processGO:009715310.0CASP3, CASP9
5tetrahydrobiopterin bindingGO:003461710.0NOS2, NOS3
6FMN bindingGO:00101819.3NOS2, NOS3
7enzyme bindingGO:00198998.9ALB, GSTM1, HIF1A, HSPA2

Sources for Varicocele

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet