MCID: VRC001
MIFTS: 50

Varicocele malady

Category: Cardiovascular diseases

Aliases & Classifications for Varicocele

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Aliases & Descriptions for Varicocele:

Name: Varicocele 11 26 49 38 13 67
 
Scrotal Varices 11

Classifications:



External Ids:

Disease Ontology11 DOID:12337
ICD1029 I86.1
ICD9CM31 456.4
MeSH38 D014646

Summaries for Varicocele

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Wikipedia:70 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to hypogonadism and infertility, and has symptoms including pain in scrotum and swelling of scrotum. An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways are Nongenotropic Androgen signaling and Hormone ligand-binding receptors. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are neoplasm and liver/biliary system.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism29.7AMH, PRL, SHBG
2infertility10.6
3mobitz type ii atrioventricular block10.6GNRH1, PRL
4benign prostate phyllodes tumor10.6GNRH1, PRL
5lipid-rich carcinoma10.6GNRH1, PRL
6retinal microaneurysm10.6GNRH1, PRL
7hypothalamic neoplasm10.5GNRH1, PRL
8oral pharyngeal disorders10.5GSTM1, GSTT1
9riedel's fibrosing thyroiditis10.5PRL, SHBG
10hemorrhoid10.4PRL, SHBG
11levic stefanovic nikolic syndrome10.4GSTM1, GSTT1
12orbital cyst10.4GSTM1, GSTT1, PRL
13prolactin producing pituitary tumor10.3GNRH1, PRL, SHBG
14uremia10.3AMH, GNRH1
15benign paroxysmal positional nystagmus10.3GNRH1, PRL, SHBG
16renal-hepatic-pancreatic dysplasia10.3CGA, GNRH1
17chondroma10.2GSTM1, GSTT1, HIF1A
18chronic frontal sinusitis10.2AMH, GNRH1
19ovarian mucinous cystadenocarcinoma10.2CASP3, GSTM1, GSTT1
20cerebellar vermis medulloblastoma10.2CASP3, GNRH1, SHBG
21ovarian hyperstimulation syndrome10.2AMH, CGA, GNRH1
22male infertility10.2
23azoospermia10.1
24asbestosis10.1FASLG, GSTM1, GSTT1
25prostatitis10.1
26elane-related neutropenia10.1CASP9, NOS2
27hypoxia10.0
28oligospermia10.0
29hydrocele9.9
30cervix carcinoma9.9AMH, GNRH1, GSTM1, GSTT1
31dental pulp necrosis9.9AMH, GNRH1, PRL, SHBG
32hidradenitis9.9AMH, GNRH1, PRL, SHBG
33lateral sclerosis9.9AMH, GNRH1, PRL, SHBG
34candidiasis9.9AMH, GNRH1, PRL, SHBG
35pseudopterygium9.9AMH, GNRH1, PRL, SHBG
36precursor b lymphoblastic lymphoma/leukemia9.9AMH, GNRH1, PRL, SHBG
37endotheliitis9.9
38female reproductive organ cancer9.9CASP3, NOS3
39munchausen by proxy9.9NOS3, PRL, SHBG
40hepatitis c9.8NOS3, PRL, SHBG
41lethal congenital contractural syndrome 29.8CASP9, NOS3
42survival motor neuron spinal muscular atrophy9.8NOS3, PRL, SHBG
43cryptorchidism9.8
44inguinal hernia9.8
45spondylitis9.8
46muscular dystrophy-dystroglycanopathy , type a, 29.8CASP3, GNRH1, HIF1A, SHBG
47pleural empyema9.7AMH, CGA, GNRH1, PRL, SHBG
48renal cell carcinoma9.7
49hepatitis9.7
50gynecomastia9.7

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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UMLS symptoms related to Varicocele:


pain in scrotum, swelling of scrotum

Drugs & Therapeutics for Varicocele

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Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ginsengapproved, nutraceuticalPhase 49250647-08-0
2
Methylene blueinvestigationalPhase 28161-73-4
Synonyms:
Basic Blue 9
C.I. basic blue 9
Lowacryl blue 9
Methylene blue
Methylene blue anhydrous
Methylthioninium chloride
 
Urolene Blue
aniline violet
methylenium ceruleum
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
Vitamin Eapproved, nutraceutical, vet_approved40659-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Hormones, Hormone Substitutes, and Hormone Antagonists12767
5Hormones13979
6Androgens1275
7Hormone Antagonists12778
8Estrogens2470
9Follicle Stimulating Hormone157
10Tocotrienols402
11Vitamins5095
12Vaccines6428
13Tocopherols406
14Anesthetics, Local3272
15Anesthetics9001
16Anti-Infective Agents, Local1785
17Central Nervous System Depressants12806
18Analgesics11287
19TocopherolNutraceutical406
20TocotrienolNutraceutical402

Interventional clinical trials:

(show all 25)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3The Role of Microsurgery in Surgical Treatment of Varicocele.RecruitingNCT02722187Phase 4
4Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele SurgeryNot yet recruitingNCT02719093Phase 4
5Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
6Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
7Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaUnknown statusNCT02306499
8Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenUnknown statusNCT00150163
9Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
10The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
11Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
12Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
13Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
14Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
15Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
16The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
17Doppler Ultrasound Assisted Varicocelectomy Improve Sperm QualitiesRecruitingNCT02695199
18Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
19The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
20Analysis on AEFI Surveillance Data for Live Attenuated Varicella VaccineActive, not recruitingNCT02983656
21Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
22Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
23Effect of TAP Block for Postoperative Pain Control After Varicocele Operations.Not yet recruitingNCT02983383
24Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
25Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

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Genetic tests related to Varicocele:

id Genetic test Affiliating Genes
1 Varicocele26

Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

35
Testis, Testes, Prostate, Endothelial, Kidney, Smooth muscle, Pituitary

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1AMH, FASLG, GNRH1, HIF1A, NOS2, PRL
2MP:00053708.6FASLG, GNRH1, HIF1A, NOS2, NOS3, PRL
3MP:00053818.5CASP3, FASLG, GNRH1, HIF1A, NOS2, NOS3
4MP:00053678.4CASP3, FASLG, GNRH1, HIF1A, NOS2, NOS3
5MP:00053897.3AMH, CASP3, CGA, FASLG, GNRH1, HSPA2
6MP:00053887.3CASP3, CASP9, FASLG, HIF1A, NOS2, NOS3
7MP:00036317.2CASP3, CASP9, CGA, FASLG, GNRH1, HIF1A
8MP:00053796.4AMH, CASP3, CASP9, CGA, FASLG, GNRH1

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Venous Blood Gases of Varicocele Veins: Correlation With Testicular Blood Flow and Semen Quality in Varicocele Patients. (27424121)
2016
2
Neck or groin access for varicocele embolisation: Is it important? (27396460)
2016
3
Testosterone and Varicocele. (27132580)
2016
4
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. (27423503)
2016
5
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
6
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
7
Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele. (26347229)
2015
8
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
9
Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele. (25168538)
2014
10
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
11
Ultrasound-guided transversus abdominis plane block for retroperitoneal varicocele repair. Could it be an anesthesia method? (23619829)
2013
12
Varicocele and value based health care. (23485504)
2013
13
Current issues in varicocele management: a review. (23658861)
2013
14
Acute left varicocele in an adult. (23382262)
2013
15
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
16
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
17
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
18
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
19
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
20
Diagnostic testicular biopsy before varicocele repair plays a realistic and important role. (21183176)
2011
21
Percutaneous retrograde endovascular occlusion for pediatric varicocele. (21376204)
2011
22
Antegrade subinguinal sclerotization with temporary clamping of the spermatic cord: a new surgical technique for varicocele. (20452656)
2011
23
The impact of varicocele and varicocele repair on serum testosterone. (21681090)
2011
24
The comparison of two experimental rat varicocele models and their effect on sperm quality. (21293112)
2011
25
Markers of accessory sex glands function in men with varicocele, relationship with seminal parameters. (22018150)
2011
26
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
27
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
28
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
29
Does G force increase the incidence of varicocele in Air Force pilot cadets? (20173373)
2010
30
Reactive oxygen species in the internal spermatic and brachial veins of patients with varicocele-induced infertility. (20495699)
2010
31
Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis. (19655149)
2010
32
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
33
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
34
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
35
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
36
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
37
The effects of varicocele and its surgical correction on vas deferens motility. (18040696)
2008
38
Relationship between varicocele grade, vein reflux and testicular growth arrest. (18421464)
2008
39
Comment on: Anatomic and hemodynamic evaluation of renal venous flow in varicocele formation using color Doppler sonography with emphasis on renal vein entrapment syndrome (Scand J Urol Nephrol 2007; 41(1): 42-6). (18365925)
2008
40
Male varicocele: transcatheter foam sclerotherapy with sodium tetradecyl sulfate--outcome in 244 patients. (18227549)
2008
41
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
42
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
43
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
44
Antisperm antibodies and varicocele. (16466113)
2006
45
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
46
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
47
Intratesticular varicocele and extratesticular varicocele in a patient with nephrotic syndrome complicated by left renal vein thrombosis. (16861853)
2006
48
The use of isosulphan blue to identify lymphatic vessels in high retroperitoneal ligation of adolescent varicocele--avoiding postoperative hydrocele. (11298043)
2001
49
The value of the gonadotrophin-releasing hormone test as a prognostic factor in infertile patients with varicocele. (8944523)
1996
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
110.0GNRH1, SHBG
29.9CGA, GNRH1
39.9GSTM1, GSTT1
49.4CASP3, CASP9
5
Show member pathways
9.3HIF1A, NOS3
69.1NOS2, NOS3
79.1NOS2, NOS3
89.1NOS2, NOS3
99.0CASP3, CASP9, HSPA2
10
Show member pathways
9.0CASP3, CGA, NOS2, PRL
118.8HIF1A, NOS2, NOS3
12
Show member pathways
8.7HSPA2, NOS2, NOS3
138.6CASP3, CASP9, NOS3
14
Show member pathways
8.6CASP3, CASP9, NOS3
15
Show member pathways
8.5CASP3, CASP9, HSPA2, NOS2
168.5CASP3, CASP9, FASLG, HSPA2
178.3CASP9, FASLG, NOS3, PRL
18
Show member pathways
8.1CASP3, CASP9, CGA, FASLG, HSPA2
198.1CASP3, CASP9, FASLG, HIF1A, NOS2
207.8CASP3, CASP9, HIF1A, NOS2, NOS3
21
Show member pathways
7.8CASP3, CASP9, FASLG, HIF1A, NOS3
22
Show member pathways
7.6CASP3, CASP9, CGA, GNRH1, HSPA2, NOS3
23
Show member pathways
7.0AMH, CASP3, CASP9, FASLG, NOS2, NOS3

GO Terms for genes affiliated with Varicocele

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Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:190168710.6GSTM1, GSTT1
2response to X-rayGO:001016510.3CASP3, HIF1A
3glial cell apoptotic processGO:003434910.0CASP3, CASP9
4platelet formationGO:003022010.0CASP3, CASP9
5response to cobalt ionGO:00320259.9CASP3, CASP9
6positive regulation of guanylate cyclase activityGO:00312849.8NOS2, NOS3
7arginine catabolic processGO:00065279.5NOS2, NOS3
8nitric oxide mediated signal transductionGO:00072639.5NOS2, NOS3
9activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00086359.4CASP3, CASP9
10cellular response to organic cyclic compoundGO:00714079.4CASP3, CASP9, HIF1A
11nitric oxide biosynthetic processGO:00068099.4NOS2, NOS3
12cell-cell signalingGO:00072679.2AMH, CGA, FASLG, GNRH1
13positive regulation of neuron apoptotic processGO:00435259.2CASP3, CASP9, FASLG
14response to organic cyclic compoundGO:00140709.2AMH, CASP3, CASP9, GNRH1
15response to estradiolGO:00323559.1CASP3, CASP9, HIF1A
16activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.0CASP3, CASP9, FASLG
17positive regulation of apoptotic processGO:00430658.5CASP3, CASP9, FASLG, HIF1A
18response to lipopolysaccharideGO:00324968.5CASP3, CASP9, FASLG, GNRH1, NOS2

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic processGO:00971539.7CASP3, CASP9
2nitric-oxide synthase activityGO:00045179.6NOS2, NOS3
3arginine bindingGO:00346189.6NOS2, NOS3
4death receptor bindingGO:00051239.6CASP3, FASLG
5tetrahydrobiopterin bindingGO:00346179.6NOS2, NOS3
6FMN bindingGO:00101819.1NOS2, NOS3
7hormone activityGO:00051799.0AMH, CGA, GNRH1, PRL

Sources for Varicocele

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet