MCID: VRC001
MIFTS: 50

Varicocele malady

Cardiovascular diseases category

Summaries for Varicocele

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66Wikipedia, 34MalaCards
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MalaCards: Varicocele, also known as scrotal varices, is related to infertility and male infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Hormone ligand-binding receptors and Glucocorticoid receptor regulatory network. The compounds deslorelin and pergonal have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Varicocele

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

varicocele 9 11 46 63
scrotal varices 9


External Ids:

Disease Ontology9 DOID:12337
ICD9CM28 456.4
MeSH36 D014646
ICD1026 I86.1

Related Diseases for Varicocele

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18GeneCards, 19GeneDecks
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Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.2AZF1, GNRH1, SHBG, AMH, PRL, CGA
2male infertility30.7PRL, SHBG, GNRH1
3azoospermia30.5AZF1, GNRH1, SHBG, AMH, PRL, ACPP
4oligospermia30.4AZF1, GNRH1, AMH, PRL, CGA
5impotence30.1SHBG, PRL
6cryptorchidism30.1CGA, AMH, SHBG, GNRH1, AZF1
7gynecomastia29.8GNRH1, SHBG, PRL, CGA
8hypogonadism29.8GNRH1, SHBG, PRL, CGA
9klinefelter's syndrome29.8AZF1, GNRH1, SHBG, PRL, CGA
10prostatitis10.4
11hypoxia10.3
12hydrocele10.3
13varicose veins10.2
14endotheliitis10.2
15mccune albright syndrome10.1GNRH1
16hermaphroditism10.1AMH
17ankylosing spondylitis10.1
18angiokeratoma10.1
19constipation10.1
20hepatitis10.1
21nephrotic syndrome10.1
22renal cell carcinoma10.1
23spondylitis10.1
24penis agenesis10.1CGA, GNRH1
25ovarian cyst10.1GNRH1, CGA
26ovarian hyperstimulation syndrome10.1GNRH1, CGA
27prostatic hypertrophy10.1GNRH1, ACPP
28aorta atresia10.1CGA, GNRH1
29penile disease10.1PRL, GNRH1
30hypogonadotropism10.1PRL, GNRH1
31kallmann syndrome10.1CGA, GNRH1
32neurogenic diabetes insipidus10.1GNRH1, PRL
33pituitary apoplexy10.1PRL, GNRH1
34pregnancy loss10.1GNRH1, CGA
35pituitary gland disease10.1GNRH1, PRL
36leydig cell tumor10.1CGA, GNRH1
37premature ovarian failure10.0GNRH1, AMH
38androgen insensitivity syndrome10.0SHBG, CGA
39turner syndrome10.0CGA, SHBG
40hypogonadism, hypergonadotropic10.0PRL, SHBG
41hypothyroidism10.0CGA, SHBG
42hyperinsulinism10.0GNRH1, SHBG
43uterine fibroid10.0SHBG, GNRH1
44cushing's syndrome10.0GNRH1, PRL
45hypothalamic disease10.0GNRH1, PRL, CGA
46abrikosov's tumor10.0GNRH1, AMH, CGA
47prolactinoma10.0GNRH1, PRL, CGA
48pituitary tumors10.0PRL, GNRH1
49hypoglycemia10.0PRL, GNRH1
50pituitary adenoma10.0CGA, PRL, GNRH1

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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Drugs & Therapeutics for Varicocele

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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34MalaCards
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MalaCards organs/tissues related to Varicocele:

34
Testes, Testis, Prostate, Kidney, Endothelial, Smooth muscle, Pituitary, Colon, Spinal cord, Brain

Animal Models for Varicocele or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Varicocele:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0GNRH1, PRL, ACPP, INHBB
2MP:00053797.8INHBB, GNRH1, AMH, PRL, CGA
3MP:00053767.8GNRH1, INHBB, PRL, CGA, AMH
4MP:00053897.7CGA, INHBB, GNRH1, AMH, PRL

Publications for Varicocele

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53PubMed
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Articles related to Varicocele:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
2
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
3
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
4
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
5
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
6
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
7
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
8
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
9
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
10
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
11
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
12
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
13
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
14
Expression of E-cadherin and I+-catenin in a varicocele-induced infertility rat model. (21399649)
2011
15
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
16
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
17
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
18
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
19
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
20
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
21
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
22
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
23
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
24
Testicular varicocele: an overview. (19506401)
2009
25
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
26
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
27
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
28
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
29
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
30
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
31
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
32
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
33
The treatment of adolescents presenting with a varicocele. (17822454)
2007
34
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
35
Varicocele-induced testicular dysfunction may be associated with disruption of blood-testis barrier. (17364465)
2007
36
Treatment of varicocele with reference to age: a retrospective comparison of three minimally invasive procedures. (17024538)
2007
37
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
38
Antisperm antibodies and varicocele. (16466113)
2006
39
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
40
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
41
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
42
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
43
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
44
Intratesticular varicocele and extratesticular varicocele in a patient with nephrotic syndrome complicated by left renal vein thrombosis. (16861853)
2006
45
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
46
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
47
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
48
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 58SinoBiological
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Compounds for genes affiliated with Varicocele

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46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1deslorelin4610.0GNRH1, CGA
2pergonal4610.0GNRH1, CGA
3metrodin4610.0GNRH1, CGA
4altrenogest4610.0CGA, GNRH1
5antarelix46 3010.9CGA, GNRH1
6ganirelix46 3010.9CGA, GNRH1
7d-trp6-lhrh469.8CGA, GNRH1
8epitestosterone469.7SHBG, CGA
9estradiol benzoate469.6CGA, GNRH1, PRL
10leuprolide46 62 30 1212.6PRL, CGA, GNRH1
11cabergoline46 30 1211.5PRL, GNRH1, CGA
12metoclopramide46 52 1211.5GNRH1, CGA, PRL
13naloxone46 30 52 1212.4GNRH1, PRL, CGA
14chlormadinone acetate469.4ACPP, SHBG
1517-hydroxypregnenolone469.4SHBG, ACPP, CGA
16toremifene46 1210.3SHBG, GNRH1, PRL
17danazol46 25 1211.3SHBG, PRL, GNRH1
18opiate469.3CGA, PRL, GNRH1
1911 deoxycortisol469.3PRL, CGA, SHBG
20metformin46 52 1211.3GNRH1, SHBG, CGA
21buserelin46 30 1211.2CGA, PRL, ACPP, GNRH1
22goserelin46 30 1211.1ACPP, CGA, GNRH1, SHBG
23diethylstilbestrol46 30 1211.0CGA, ACPP, GNRH1, SHBG
24dhea469.0ACPP, PRL, SHBG
25leuprolide acetate469.0GNRH1, SHBG, CGA, PRL
26clomiphene citrate469.0CGA, GNRH1, SHBG, PRL
27bromocriptine46 30 1211.0CGA, PRL, SHBG, GNRH1
28progestin468.9SHBG, PRL, CGA, GNRH1
29cyproteroneacetate468.9PRL, SHBG, GNRH1, ACPP
30thyroxine46 259.9SHBG, GNRH1, PRL, CGA
31acth468.8ACPP, PRL, SHBG, GNRH1
32epinephrine46 25 1210.8PRL, CGA, GNRH1, SHBG
33triiodothyronine468.8PRL, SHBG, CGA
34norepinephrine46 25 1210.8SHBG, PRL, GNRH1, CGA
35dopamine46 30 25 1211.5GNRH1, SHBG, CGA, PRL
3617-hydroxyprogesterone46 259.5SHBG, CGA, GNRH1, PRL, ACPP
37flutamide46 62 1210.5SHBG, CGA, PRL, GNRH1, ACPP
38dehydroepiandrosterone sulfate468.5GNRH1, SHBG, PRL, ACPP, CGA
39androstenedione46 259.5PRL, CGA, GNRH1, SHBG, ACPP
40dihydrotestosterone46 30 25 1211.5CGA, ACPP, PRL, SHBG, GNRH1
41mifepristone46 30 62 1211.5PRL, CGA, SHBG, GNRH1, AMH
42tamoxifen46 52 30 1211.4CGA, PRL, SHBG, GNRH1, AMH
43steroid468.4CGA, ACPP, PRL, SHBG, GNRH1
44arginine468.4CGA, PRL, SHBG, GNRH1, ACPP
45lactate468.3GNRH1, CGA, SHBG, ACPP
46estradiol46 25 1210.0ACPP, PRL, AMH, SHBG, GNRH1, CGA
47progesterone46 30 62 25 1212.0ACPP, CGA, PRL, AMH, SHBG, GNRH1
48testosterone46 62 25 1211.0CGA, ACPP, PRL, AMH, SHBG, GNRH1
49estrogen467.9SHBG, AMH, PRL, ACPP, GNRH1, CGA
50gnrh467.7PRL, GNRH1, CGA, SHBG, ACPP, INHBB

GO Terms for genes affiliated with Varicocele

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17Gene Ontology
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Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2CGA, PRL, AMH, SHBG, GNRH1, INHBB

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.6PRL, GNRH1
2cell-cell signalingGO:0072678.9CGA, AMH, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051797.8CGA, PRL, AMH, GNRH1, INHBB

Products for genes affiliated with Varicocele

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Sources for Varicocele

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet