Aliases & Classifications for Varicocele

Aliases & Descriptions for Varicocele:

Name: Varicocele 12 29 52 42 14 69
Scrotal Varices 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12337
ICD10 33 I86.1
ICD9CM 35 456.4
MeSH 42 D014646
UMLS 69 C0042341

Summaries for Varicocele

MalaCards based summary : Varicocele, also known as scrotal varices, is related to retroperitoneal sarcoma and infertility, and has symptoms including pain in scrotum An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are PEDF Induced Signaling and Allograft rejection. The drugs Ginseng and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 71 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

Related Diseases for Varicocele

Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 retroperitoneal sarcoma 26.6 AMH AZF1 CASP3 CASP9 CGA FASLG
2 infertility 10.6
3 19p13.12 microdeletion syndrome 10.3 AZF1 PRL
4 african histoplasmosis 10.3 GNRH1 PRL
5 endometriosis 10.3 GNRH1 PRL
6 diverticulitis 10.3 GNRH1 PRL
7 intermittent squint 10.2 GNRH1 PRL
8 vertebral artery occlusion 10.2 GNRH1 PRL
9 hole retinal cyst 10.2 GNRH1 HIF1A
10 extragonadal nonseminomatous germ cell tumor 10.2 GNRH1 PRL
11 gastrointestinal tularemia 10.2 GSTM1 GSTT1 PRL
12 capillary disease 10.2 CGA PRL SHBG
13 astroblastoma 10.2 GNRH1 PRL SHBG
14 pelvic muscle wasting 10.2 GNRH1 PRL SHBG
15 acute gonococcal salpingitis 10.2 GNRH1 PRL SHBG
16 glomangiomyoma 10.2 CGA PRL SHBG
17 olfactory nerve neoplasm 10.2 GNRH1 PRL
18 male infertility 10.1
19 breast myoepithelial neoplasm 10.1 AZF1 CGA SHBG
20 azoospermia 10.1
21 primary biliary cirrhosis 10.1 GNRH1 PRL SHBG
22 ovarian mucinous adenocarcinoma 10.1 CASP3 GSTM1 GSTT1
23 ornithinemia 10.1 CASP3 GSTM1 GSTT1
24 epidural spinal canal meningioma 10.1 CGA GNRH1 PRL SHBG
25 adult medulloblastoma 10.1 CASP3 GNRH1 SHBG
26 villous adenoma 10.1 GSTM1 GSTT1 NOS3
27 aphasia 10.1 NOS3 PRL SHBG
28 immune system disease 10.1 GNRH1 GSTM1 GSTT1
29 spinocerebellar ataxia 25 10.1 AMH CGA GNRH1
30 prostatitis 10.1
31 intramuscular hemangioma 10.0 AMH GNRH1
32 hypoxia 10.0
33 body dysmorphic disorder 10.0 NOS3 PRL SHBG
34 oligospermia 10.0
35 sphingolipidosis 10.0 AMH GNRH1 PRL SHBG
36 capillary lymphangioma 10.0 AMH GNRH1 PRL SHBG
37 spondylolysis 10.0 AMH GNRH1 PRL SHBG
38 avoidant personality disorder 10.0 AMH GNRH1 PRL SHBG
39 hydrocele 9.9
40 endotheliitis 9.9
41 viral hepatitis 9.9 NOS2 NOS3 PRL SHBG
42 senile atrophy of choroid 9.9 CASP3 NOS2
43 thanatophoric dysplasia, type ii 9.9 CASP3 CASP9 HIF1A
44 thrombosis 9.9
45 pinguecula 9.9 AMH CGA GNRH1 PRL SHBG
46 diabetes mellitus, insulin-resistant, with acanthosis nigricans 9.8 AMH AZF1 CGA GNRH1 SHBG
47 gaucher's disease 9.8 AMH AZF1 GNRH1 PRL SHBG
48 mucinous ovarian cystadenoma 9.8 CASP3 HIF1A NOS2 NOS3
49 spondylitis 9.8
50 cryptorchidism 9.8

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to Varicocele

Symptoms & Phenotypes for Varicocele

UMLS symptoms related to Varicocele:


pain in scrotum

MGI Mouse Phenotypes related to Varicocele:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 AMH CASP3 CASP9 CGA FASLG GNRH1
2 digestive/alimentary MP:0005381 9.91 FASLG GNRH1 CASP3 HIF1A NOS2 NOS3
3 nervous system MP:0003631 9.91 CASP3 CASP9 CGA FASLG GNRH1 HIF1A
4 liver/biliary system MP:0005370 9.85 FASLG GNRH1 HIF1A NOS2 NOS3 PRL
5 neoplasm MP:0002006 9.8 PRL AMH FASLG GNRH1 HIF1A NOS2
6 renal/urinary system MP:0005367 9.63 CASP3 FASLG GNRH1 HIF1A NOS2 NOS3
7 reproductive system MP:0005389 9.61 AMH CASP3 CGA FASLG GNRH1 HSPA2
8 respiratory system MP:0005388 9.1 CASP3 CASP9 FASLG HIF1A NOS2 NOS3

Drugs & Therapeutics for Varicocele

Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
2
Methylene blue Investigational Phase 2 61-73-4
3
Sodium Tetradecyl Sulfate Approved 1191-50-0, 139-88-8 14492 5248
4
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
5 Androgens
6 Estrogens
7 Hormone Antagonists
8 Hormones
9 Hormones, Hormone Substitutes, and Hormone Antagonists
10 Analgesics
11 Anesthetics
12 Anesthetics, Local
13 Anti-Infective Agents, Local
14 Central Nervous System Depressants
15 Follicle Stimulating Hormone
16 Vaccines
17 Tocopherols
18 Tocotrienols
19 Vitamins
20 Tocopherol Nutraceutical
21 Tocotrienol Nutraceutical

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
2 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4
3 The Role of Microsurgery in Surgical Treatment of Varicocele. Recruiting NCT02722187 Phase 4
4 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Not yet recruiting NCT02719093 Phase 4
5 Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis Terminated NCT00767338 Phase 3
6 Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy Completed NCT01259258 Phase 2
7 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
8 The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analisy Unknown status NCT02401087
9 Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE Unknown status NCT02033863
10 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
11 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
12 The Effect of Spermatic Vein Embolization on Prostatic Hypertrophy Completed NCT00639899
13 Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility Completed NCT02006316
14 Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate Cancer Completed NCT00637208
15 Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy Completed NCT02092311
16 Single Incision Laparoscopic Varicocelectomy Completed NCT02335385
17 Varicocelectomy To Treat Pain, Predictors Of Success Completed NCT01395186
18 Effect of TAP Block for Postoperative Pain Control After Varicocele Operations. Recruiting NCT02983383
19 The Search for Viral and Bacterial Etiology of Varicocele Recruiting NCT03079609
20 Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities Recruiting NCT02695199
21 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
22 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548
23 Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine Active, not recruiting NCT02983656
24 Oxidative Stress and Lipidomics in Male Infertility Active, not recruiting NCT02062229
25 IVF Outcomes After Varicocele Repair Not yet recruiting NCT03090438
26 Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy Terminated NCT00961558
27 Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality? Terminated NCT01296230

Search NIH Clinical Center for Varicocele

Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

Genetic tests related to Varicocele:

id Genetic test Affiliating Genes
1 Varicocele 29

Anatomical Context for Varicocele

MalaCards organs/tissues related to Varicocele:

39
Testis, Testes, Prostate, Endothelial, Kidney, Smooth Muscle, Pituitary

Publications for Varicocele

Articles related to Varicocele:

(show top 50) (show all 661)
id Title Authors Year
1
Re: Increased Body Mass Index in Men with Varicocele is Associated with Larger Spermatic Vein Diameters when Supine. ( 27979554 )
2017
2
The varicocele as related to fertility. ( 27842996 )
2017
3
Randomised clinical trial of comparing effects of acupuncture and varicocelectomy on sperm parameters in infertile varicocele patients. ( 28083932 )
2017
4
An association between sperm PLCIP levels and varicocele? ( 27612872 )
2016
5
Effects of experimental left varicocele repair on hypoxia-inducible factor-1I+ and vascular endothelial growth factor expressions and angiogenesis in rat testis. ( 27178282 )
2016
6
Editorial Comment to Surgical comparison of subinguinal and high inguinal microsurgical varicocelectomy for adolescent varicocele. ( 26919278 )
2016
7
The Varicocele: Clinical Presentation, Evaluation, and Surgical Management. ( 27582602 )
2016
8
Can Ultrasound Findings be a Good Predictor of Sperm Parameters in Patients With Varicocele? A Cross-Sectional Study. ( 27878108 )
2016
9
Diagnosis and Management of Pediatric and Adolescent Varicocele: A Survey of Pediatric Urologists in Korea. ( 27689031 )
2016
10
Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11 which Forms Inter-Sertoli Tight Junctions in Varicocele Rat Testes. ( 27164517 )
2016
11
Re: Jakob Damsgaard, Ulla N. Joensen, Elisabeth Carlsen, et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.044: Treating varicocele and when to treat? That is the question today and maybe for some time yet. ( 27641788 )
2016
12
Venous Blood Gases of Varicocele Veins: Correlation With Testicular Blood Flow and Semen Quality in Varicocele Patients. ( 27424121 )
2016
13
The Role of Sonoelastography in the Evaluation of Testes With Varicocele. ( 27521065 )
2016
14
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. ( 27595632 )
2016
15
The natural history of semen parameters in untreated asymptomatic adolescent varicocele patients: A retrospective cohort study. ( 27815047 )
2016
16
Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. ( 27526630 )
2016
17
Alterations in the proliferative/apoptotic equilibrium in semen of adolescents with varicocele. ( 27629121 )
2016
18
Tracing of zinc and iron in experimentally induced varicocele: correlation with oxidative, nitrosative and carbonyl stress. ( 27682184 )
2016
19
Varicocele among infertile men in Qatar. ( 27401026 )
2016
20
Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele. ( 28105423 )
2016
21
Effects of varicocele on DNA methylation pattern of H19 and Snrpn gene in spermatozoa and behavioural characteristics of adult rat offspring. ( 27071665 )
2016
22
Re: Varicocele Negatively Affects Sperm Mitochondrial Respiration. ( 27191106 )
2016
23
Re: Evaluation and Management of the Adolescent Varicocele: T. F. Kolon J Urol 2015;194:1194-1201. ( 27154562 )
2016
24
Varicocele: tissue stress in the etiology. ( 27513398 )
2016
25
Neck or groin access for varicocele embolisation: Is it important? ( 27396460 )
2016
26
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. ( 27423503 )
2016
27
Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele. ( 28073193 )
2016
28
Varicocele - a case for early intervention. ( 27508071 )
2016
29
Relationship between mean platelet volume, platelet distribution width, plateletcrit and varicocele. ( 27135841 )
2016
30
Who will benefit from surgical repair for painful varicocele: a meta-analysis. ( 27074742 )
2016
31
First report of a spermatic granuloma and varicocele in a marsupial: A Koala (Phascolarctos cinereus) Case Study. ( 27473971 )
2016
32
The Relationship Between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele. ( 26866567 )
2016
33
Spermiogram and sperm head morphometry assessed by multivariate cluster analysis results during adolescence (12-18 years) and the effect of varicocele. ( 27751986 )
2016
34
Surgical approaches for varicocele in pediatric patient. ( 27867844 )
2016
35
Aberrant expressions of stem cell factor/c-KIT in rat testis with varicocele. ( 27707610 )
2016
36
Varicocele in a Young Man: Something We Should Be Worried About? ( 27481181 )
2016
37
Comparison of the Effects of Varicocelectomy and Oral L-carnitine on Sperm Parameters in Infertile Men with Varicocele. ( 27190879 )
2016
38
Is varicocele repair necessary, given the advanced state of assisted reproductive technologies? ( 27056348 )
2016
39
Risk of varicocele in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic disease: a population-based case-control study. ( 27973977 )
2016
40
Evaluation of enzymatic and non-enzymatic antioxidants in seminal plasma of men with genitourinary infections, varicocele and idiopathic infertility. ( 27027567 )
2016
41
A correlation between selenium and carnitine levels with hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients. ( 26957259 )
2016
42
Reply to Eugenio Ventimiglia, Francesco Montorsi, and Andrea Salonia's Letter to the Editor re: Jakob Damsgaard, Ulla N. Joensen, Elisabeth Carlsen, et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.044. ( 27638092 )
2016
43
Inflammatory and anti-inflammatory cytokines in the seminal plasma of infertile men suffering from varicocele. ( 27709650 )
2016
44
Laparoendoscopic single-site surgery varicocelectomy versus conventional laparoscopic varicocele ligation: A meta-analysis. ( 27688686 )
2016
45
Dilating venous diseases: Varicocele and varicose vein. ( 27989727 )
2016
46
Steroid receptors in human ejaculated sperm as molecular markers of the detrimental effects related to the pathophysiology of testicular varicocele. ( 27031584 )
2016
47
Prognostic Predictors of Fertility in Young Adult Patients With Varicocele: Peak Retrograde Flow Velocity and Reflux Grade. ( 27151907 )
2016
48
Varicocele management in the era of in vitro fertilization/intracytoplasmic sperm injection. ( 27030086 )
2016
49
Testosterone and Varicocele. ( 27132580 )
2016
50
Increased expression of the sonic hedgehog and vascular endothelial growth factor with co-localization in varicocele veins. ( 26867642 )
2016

Variations for Varicocele

Expression for Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for Varicocele

Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 AMH CASP3 CASP9 FASLG NOS2 NOS3
2
Show member pathways
12.66 CASP3 CASP9 CGA FASLG HSPA2
3
Show member pathways
12.58 CASP3 CASP9 FASLG HIF1A NOS3
4 12.43 CASP9 FASLG NOS3 PRL
5
Show member pathways
12.42 CASP3 CASP9 CGA GNRH1 HSPA2 NOS3
6 12.36 CASP3 CASP9 FASLG HIF1A NOS2
7
Show member pathways
12.17 CASP3 CGA NOS2 NOS3 PRL
8
Show member pathways
12.01 CASP3 CASP9 FASLG HIF1A
9
Show member pathways
11.98 CASP3 CASP9 HSPA2 NOS2
10 11.93 GSTM1 GSTT1 NOS3
11 11.82 FASLG HIF1A NOS2
12 11.76 HIF1A NOS2 NOS3
13 11.7 CASP3 CASP9 NOS3
14
Show member pathways
11.65 CASP3 CASP9 FASLG
15
Show member pathways
11.63 CASP3 CASP9 NOS3
16
Show member pathways
11.42 HSPA2 NOS2 NOS3
17 11.42 CASP3 CASP9 FASLG GSTM1 GSTT1
18 11.37 CASP3 CASP9 HSPA2
19 11.17 CASP3 CASP9 HIF1A NOS2 NOS3
20 11.01 HIF1A NOS3
21 11.01 NOS2 NOS3
22 11 GSTM1 GSTT1
23 10.98 CASP3 CASP9
24 10.86 GNRH1 SHBG
25 10.73 CASP3 CASP9 FASLG HIF1A NOS2
26 10.69 CGA GNRH1
27 10.68 NOS2 NOS3
28 10.41 NOS2 NOS3

GO Terms for Varicocele

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.84 AMH CGA FASLG GNRH1
2 response to estradiol GO:0032355 9.7 CASP3 CASP9 PRL
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.63 CASP3 CASP9 FASLG
4 glutathione derivative biosynthetic process GO:1901687 9.57 GSTM1 GSTT1
5 platelet formation GO:0030220 9.56 CASP3 CASP9
6 nitric oxide mediated signal transduction GO:0007263 9.55 NOS2 NOS3
7 nitric oxide biosynthetic process GO:0006809 9.51 NOS2 NOS3
8 gonad development GO:0008406 9.49 AMH CGA
9 positive regulation of guanylate cyclase activity GO:0031284 9.48 NOS2 NOS3
10 ovulation cycle GO:0042698 9.43 GNRH1 PRL
11 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.4 CASP3 CASP9
12 arginine catabolic process GO:0006527 9.37 NOS2 NOS3
13 response to organic cyclic compound GO:0014070 9.35 AMH CASP3 CASP9 GNRH1 PRL
14 positive regulation of neuron apoptotic process GO:0043525 9.33 CASP3 CASP9 FASLG
15 response to cobalt ion GO:0032025 9.32 CASP3 CASP9
16 glial cell apoptotic process GO:0034349 9.26 CASP3 CASP9
17 response to lipopolysaccharide GO:0032496 9.1 CASP3 CASP9 FASLG GNRH1 NOS2 PRL

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glutathione transferase activity GO:0004364 9.46 GSTM1 GSTT1
2 FMN binding GO:0010181 9.43 NOS2 NOS3
3 death receptor binding GO:0005123 9.4 CASP3 FASLG
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP3 CASP9
5 arginine binding GO:0034618 9.32 NOS2 NOS3
6 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS2 NOS3
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS2 NOS3
8 nitric-oxide synthase activity GO:0004517 8.96 NOS2 NOS3
9 hormone activity GO:0005179 8.92 AMH CGA GNRH1 PRL

Sources for Varicocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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