MCID: VRC001
MIFTS: 51

Varicocele malady

Cardiovascular diseases category
Download this MalaCard

Summaries for Varicocele

About this section


Fully expand this MalaCard
Wikipedia:65 A varicocele /?v more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to male infertility and infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Hormone ligand-binding receptors and Glucocorticoid receptor regulatory network. The compounds deslorelin and pergonal have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Varicocele

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 25ICD10
See all sources

Varicocele, Aliases & Descriptions:

Name: Varicocele 8 10 44 62
 
Scrotal Varices 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:12337
ICD9CM27 456.4
MeSH34 D014646
ICD1025 I86.1

Related Diseases for Varicocele

About this section

Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1male infertility30.8GNRH1, PRL, SHBG
2infertility30.6AZF1, SHBG, GNRH1, CGA, PRL, AMH
3impotence30.3SHBG, PRL
4oligospermia30.1GNRH1, AMH, PRL, CGA, AZF1
5gynecomastia29.9SHBG, PRL, CGA, GNRH1
6cryptorchidism29.8AZF1, SHBG, AMH, CGA, GNRH1
7hypogonadism29.6CGA, PRL, SHBG, GNRH1
8azoospermia29.6ACPP, CGA, AZF1, GNRH1, SHBG, AMH
9klinefelter's syndrome29.4PRL, GNRH1, CGA, SHBG, AZF1
10mccune albright syndrome10.5GNRH1
11prostatitis10.4
12hermaphroditism10.4AMH
13hypoxia10.4
14hydrocele10.3
15penis agenesis10.3GNRH1, CGA
16ovarian cyst10.3GNRH1, CGA
17ovarian hyperstimulation syndrome10.3GNRH1, CGA
18prostatic hypertrophy10.3ACPP, GNRH1
19aorta atresia10.3CGA, GNRH1
20penile disease10.3PRL, GNRH1
21kallmann syndrome10.2GNRH1, CGA
22hypogonadotropism10.2GNRH1, PRL
23neurogenic diabetes insipidus10.2PRL, GNRH1
24pregnancy loss10.2GNRH1, CGA
25pituitary apoplexy10.2PRL, GNRH1
26varicose veins10.2
27pituitary gland disease10.2PRL, GNRH1
28leydig cell tumor10.2CGA, GNRH1
29premature ovarian failure10.2GNRH1, AMH
30endotheliitis10.2
31androgen insensitivity syndrome10.2SHBG, CGA
32turner syndrome10.1CGA, SHBG
33hypogonadism, hypergonadotropic10.1SHBG, PRL
34hypothyroidism10.1CGA, SHBG
35hyperinsulinism10.1SHBG, GNRH1
36uterine fibroid10.1SHBG, GNRH1
37cushing's syndrome10.1GNRH1, PRL
38hypothalamic disease10.1PRL, GNRH1, CGA
39ankylosing spondylitis10.1
40hepatitis10.1
41renal cell carcinoma10.1
42angiokeratoma10.1
43constipation10.1
44nephrotic syndrome10.1
45spondylitis10.1
46abrikosov's tumor10.1CGA, GNRH1, AMH
47prolactinoma10.1PRL, GNRH1, CGA
48pituitary tumors10.1GNRH1, PRL
49hypoglycemia10.1PRL, GNRH1
50pituitary adenoma10.1GNRH1, CGA, PRL

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

About this section

Drugs & Therapeutics for Varicocele

About this section

Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Genetic Tests for Varicocele

About this section

Anatomical Context for Varicocele

About this section

MalaCards organs/tissues related to Varicocele:

32
Testes, Testis, Prostate, Kidney, Smooth muscle, Endothelial, Pituitary, Brain, Spinal cord, Colon

Animal Models for Varicocele or affiliated genes

About this section

MGI Mouse Phenotypes related to Varicocele:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0GNRH1, PRL, ACPP, INHBB
2MP:00053797.8INHBB, GNRH1, AMH, PRL, CGA
3MP:00053767.8GNRH1, INHBB, PRL, CGA, AMH
4MP:00053897.7CGA, INHBB, GNRH1, AMH, PRL

Publications for Varicocele

About this section

Articles related to Varicocele:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study. (25405715)
2014
2
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele. (25179750)
2014
3
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
4
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
5
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
6
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
7
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
8
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
9
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
10
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
11
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
12
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
13
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
14
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
15
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
16
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
17
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
18
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
19
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
20
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
21
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
22
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
23
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
24
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
25
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
26
Testicular varicocele: an overview. (19506401)
2009
27
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
28
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
29
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
30
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
31
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
32
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
33
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
34
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
35
The treatment of adolescents presenting with a varicocele. (17822454)
2007
36
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
37
Varicocele-induced testicular dysfunction may be associated with disruption of blood-testis barrier. (17364465)
2007
38
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
39
Antisperm antibodies and varicocele. (16466113)
2006
40
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
41
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
42
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
43
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
44
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
45
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
46
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
47
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
48
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

About this section

Expression for genes affiliated with Varicocele

About this section
Expression patterns in normal tissues for genes affiliated with Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

About this section

Compounds for genes affiliated with Varicocele

About this section

Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1deslorelin4410.0GNRH1, CGA
2pergonal4410.0GNRH1, CGA
3metrodin4410.0GNRH1, CGA
4altrenogest4410.0CGA, GNRH1
5antarelix44 2810.9CGA, GNRH1
6ganirelix44 2810.9CGA, GNRH1
7d-trp6-lhrh449.8CGA, GNRH1
8epitestosterone449.7SHBG, CGA
9estradiol benzoate449.6CGA, GNRH1, PRL
10leuprolide44 61 28 1112.6PRL, CGA, GNRH1
11cabergoline44 28 1111.5PRL, GNRH1, CGA
12metoclopramide44 50 1111.5GNRH1, CGA, PRL
13naloxone44 28 50 1112.4GNRH1, PRL, CGA
14chlormadinone acetate449.4ACPP, SHBG
1517-hydroxypregnenolone449.4SHBG, ACPP, CGA
16toremifene44 1110.3SHBG, GNRH1, PRL
17danazol44 24 1111.3SHBG, PRL, GNRH1
18opiate449.3CGA, PRL, GNRH1
1911 deoxycortisol449.3PRL, CGA, SHBG
20metformin44 50 1111.3GNRH1, SHBG, CGA
21buserelin44 28 1111.2CGA, PRL, ACPP, GNRH1
22goserelin44 28 1111.1ACPP, CGA, GNRH1, SHBG
23diethylstilbestrol44 28 1111.0CGA, ACPP, GNRH1, SHBG
24dhea449.0ACPP, PRL, SHBG
25leuprolide acetate449.0GNRH1, SHBG, CGA, PRL
26clomiphene citrate449.0CGA, GNRH1, SHBG, PRL
27bromocriptine44 28 1111.0CGA, PRL, SHBG, GNRH1
28progestin448.9SHBG, PRL, CGA, GNRH1
29cyproteroneacetate448.9PRL, SHBG, GNRH1, ACPP
30thyroxine44 249.9SHBG, GNRH1, PRL, CGA
31acth448.8ACPP, PRL, SHBG, GNRH1
32epinephrine44 24 1110.8PRL, CGA, GNRH1, SHBG
33triiodothyronine448.8PRL, SHBG, CGA
34norepinephrine44 24 1110.8SHBG, PRL, GNRH1, CGA
35dopamine44 28 24 1111.5GNRH1, SHBG, CGA, PRL
3617-hydroxyprogesterone44 249.5SHBG, CGA, GNRH1, PRL, ACPP
37flutamide44 61 1110.5SHBG, CGA, PRL, GNRH1, ACPP
38dehydroepiandrosterone sulfate448.5GNRH1, SHBG, PRL, ACPP, CGA
39androstenedione44 249.5PRL, CGA, GNRH1, SHBG, ACPP
40dihydrotestosterone44 28 24 1111.5CGA, ACPP, PRL, SHBG, GNRH1
41mifepristone44 28 61 1111.5PRL, CGA, SHBG, GNRH1, AMH
42tamoxifen44 50 28 1111.4CGA, PRL, SHBG, GNRH1, AMH
43steroid448.4CGA, ACPP, PRL, SHBG, GNRH1
44arginine448.4CGA, PRL, SHBG, GNRH1, ACPP
45lactate448.3GNRH1, CGA, SHBG, ACPP
46estradiol44 24 1110.0ACPP, PRL, AMH, SHBG, GNRH1, CGA
47progesterone44 28 61 24 1112.0ACPP, CGA, PRL, AMH, SHBG, GNRH1
48testosterone44 61 24 1111.0CGA, ACPP, PRL, AMH, SHBG, GNRH1
49estrogen447.9SHBG, AMH, PRL, ACPP, GNRH1, CGA
50gnrh447.7PRL, GNRH1, CGA, SHBG, ACPP, INHBB

GO Terms for genes affiliated with Varicocele

About this section

Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2CGA, PRL, AMH, SHBG, GNRH1, INHBB

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:0075659.6PRL, GNRH1
2cell-cell signalingGO:0072678.9CGA, AMH, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051797.8CGA, PRL, AMH, GNRH1, INHBB

Products for genes affiliated with Varicocele

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Varicocele

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet