MCID: VRC001
MIFTS: 43

Varicocele malady

Category: Cardiovascular diseases

Aliases & Classifications for Varicocele

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Aliases & Descriptions for Varicocele:

Name: Varicocele 10 47 12 36 65
 
Scrotal Varices 10

Classifications:



External Ids:

Disease Ontology10 DOID:12337
ICD1027 I86.1
ICD9CM29 456.4
MeSH36 D014646
UMLS65 C0042341

Summaries for Varicocele

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Wikipedia:68 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to dysostosis and arteriovenous malformation. An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways are Naphthalene metabolism and Hormone ligand-binding receptors. Affiliated tissues include testis, breast and liver, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 470)
idRelated DiseaseScoreTop Affiliating Genes
1dysostosis30.5GNRH1, PRL
2arteriovenous malformation30.3GNRH1, PRL
3pituitary adenoma29.9GNRH1, PRL, TP53
4ovarian hyperstimulation syndrome29.5ALB, AMH, CGA, GNRH1
5hepatocellular carcinoma28.7ALB, CASP3, HIF1A, PARP1, TP53
6prostate cancer28.5CASP3, GNRH1, HIF1A, IL6, PARP1, PRL
7breast cancer28.3CASP3, GNRH1, HIF1A, IL6, PARP1, PRL
8esophageal cancer27.9ALB, CASP3, GSTM1, HIF1A, IL6, TP53
9cercarial dermatitis10.5GNRH1, PRL
10cranial nerve disease10.5GNRH1, PRL
11enterobiasis10.4GNRH1, PRL
12penoscrotal transposition10.4CGA, GNRH1
13hematocele of tunica vaginalis testis10.4GNRH1, PRL
14prostatocystitis10.4GNRH1, PRL
15zap70-related severe combined immunodeficiency10.4AZF1, PRL
16epididymal neoplasm10.4GNRH1, PRL
17uremic neuropathy10.4AMH, GNRH1
18external ear disease10.3CGA, GNRH1, PRL
19perianal hematoma10.3GNRH1, PRL
20setariasis10.3AMH, GNRH1
21prostatitis10.3
22lipoadenoma10.3PRL, TP53
23scleromalacia perforans10.3GSTM1, GSTT1, PRL
24hypogonadism10.2AMH, GNRH1, PRL
25hidradenitis suppurativa10.2AMH, GNRH1, PRL
26dowling-degos disease10.2CGA, GNRH1
27leukemia10.2
28endotheliitis10.2
29nodular episcleritis10.2GNRH1, PRL
30urethra inverted papilloma10.2PARP1, TP53
31gastric cancer10.2
32hepatitis10.2
33cervicitis10.2
34neuronitis10.2
35cardiomyopathy10.1
36mutiple parosteal osteochondromatous proliferations10.1GSTM1, GSTT1, TP53
37colorectal cancer10.1
38lung cancer10.1
39obesity10.1
40dermatitis10.1
41pancreatitis10.1
42neuropathy10.1
43anorectal stricture10.1AMH, CGA, GNRH1, PRL
44mucinous cystadenocarcinoma10.1CASP3, GSTM1, GSTT1
45periocular meningioma10.1GSTM1, GSTT1, TP53
46leprechaunism10.1AMH, AZF1, CGA, GNRH1
47cardiovascular organ benign neoplasm10.1PRL, TP53
48atrial heart septal defect10.1ALB, GNRH1, PRL
49sex differentiation disease10.1AMH, AZF1, GNRH1, PRL
50acute monocytic leukemia10.1GSTM1, GSTT1, TP53

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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Drugs & Therapeutics for Varicocele

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Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ginsengapproved, nutraceuticalPhase 48750647-08-0
2
methylene bluePhase 271
Synonyms:
Urolene Blue
aniline violet
 
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
Vitamin Eapproved, nutraceutical37159-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Hormones11748
5Androgens1162
6Follicle Stimulating Hormone151
7Hormones, Hormone Substitutes, and Hormone Antagonists9988
8Estrogens2144
9Hormone Antagonists10002
10Vitamins3857
11Tocopherols376
12Tocotrienols372
13TocopherolNutraceutical376
14TocotrienolNutraceutical372

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3The Role of Microsurgery in Surgical Treatment of Varicocele.RecruitingNCT02722187Phase 4
4Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele SurgeryNot yet recruitingNCT02719093Phase 4
5Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
6Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
7Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
8The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
9Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
10Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
11Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
12Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
13Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
14Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaRecruitingNCT02306499
15The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
16Doppler Ultrasound Assisted Varicocelectomy Improve Sperm QualitiesRecruitingNCT02695199
17Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
18The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
19Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
20Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenActive, not recruitingNCT00150163
21Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
22Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
23Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

33
Testis, Breast, Liver, Prostate, Brain, Bone, Endothelial

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3ALB, GNRH1, HIF1A, IL6, PRL, TP53
2MP:00020067.9ALB, AMH, GNRH1, HIF1A, IL6, PRL
3MP:00053817.7ALB, CASP3, GNRH1, HIF1A, IL6, TP53
4MP:00107717.4CASP3, GNRH1, HIF1A, IL6, PARP1, PRL
5MP:00053796.7ALB, AMH, CASP3, CGA, GNRH1, HIF1A
6MP:00053676.7ALB, CASP3, GNRH1, HIF1A, IL6, PARP1
7MP:00053896.5AMH, CASP3, CGA, GNRH1, HSPA2, IL6
8MP:00053766.0ALB, AMH, CASP3, CGA, GNRH1, HIF1A

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Case report of chylous ascites with strangulated ileus and review of the literature. (26026475)
2015
2
Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. (24629239)
2014
3
HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2. (24295734)
2014
4
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. (24105071)
2013
5
Split cord malformation. (23965632)
2013
6
Congenital giant craniopharyngioma. (22983633)
2013
7
Mesial temporal lobe epilepsy in a patient with spinocerebellar ataxia type 13 (SCA13). (23215817)
2013
8
Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy. (21913013)
2012
9
Real-time imaging of plasma membrane deformations reveals pre-fusion membrane curvature changes and a role for dynamin in the regulation of fusion pore expansion. (22671293)
2012
10
Whole-exome sequencing in a single proband reveals a mutation in the CHST8 gene in autosomal recessive peeling skin syndrome. (22289416)
2012
11
Partial urethral obstruction: ATF3 and p-c-Jun are involved in the growth of the detrusor muscle and its motor innervation. (20969496)
2011
12
Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. (21471287)
2011
13
Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. (22239028)
2011
14
Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth. (21674124)
2011
15
Is antenatal detection of Wilms' tumor a bad prognostic marker? (22563156)
2011
16
Perspectives of nuclear diagnostic imaging in diabetic cardiomyopathy. (19939648)
2010
17
CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets. (19897577)
2010
18
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. (20237833)
2010
19
Immunohistochemical detection of somatostatin receptor subtype 5 (SSTR-5) in cushing adenoma. (19894022)
2010
20
Successful treatment of an intractable postherpetic neuralgia (PHN) using peripheral nerve field stimulation (PNFS). (19700650)
2010
21
Regulation of phosphoinositide 3-kinase expression in health and disease. (19299143)
2009
22
Intravitreal combination of triamcinolone acetonide and bevacizumab (Kenacort-Avastin) in diffuse diabetic macular edema. (19954371)
2009
23
Epidermal growth factor promotes epidermal growth factor receptor nuclear accumulation by a pathway dependent on cytoskeleton integrity in human breast cancer cells. (19766894)
2009
24
JunB as a potential mediator of PTHrP actions: new gene targets Ephrin B1 and VCAM-1. (19193201)
2008
25
A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation. (18929331)
2008
26
Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and quadriplegia. (18644072)
2008
27
Relationship between growth hormone in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density in young, physically fit men and women. (18482854)
2008
28
Identification of different isoforms of 14-3-3 protein family in human dermal and epidermal layers. (18465211)
2008
29
Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. (18519066)
2008
30
Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells. (17551930)
2007
31
Treatment of social phobia through pure self-help and therapist-augmented self-help. (17766766)
2007
32
Inhibition of tumor necrosis factor-alpha attenuates myocardial remodeling in rat cardiac allografts. (16678037)
2006
33
Reversed actrocytic GLT-1 during ischemia is crucial to excitotoxic death of neurons, but contributes to the survival of astrocytes themselves. (16830212)
2006
34
Gliadin fragments induce phenotypic and functional maturation of human dendritic cells. (16272365)
2005
35
Llama-derived phage display antibodies in the dissection of the human disease oculopharyngeal muscular dystrophy. (12969556)
2003
36
Low mortality rates related to respiratory virus infections after bone marrow transplantation. (12692610)
2003
37
The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. (14671211)
2003
38
Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. (12453540)
2002
39
Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase. (12186557)
2002
40
The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53. (12642691)
2002
41
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. (11251179)
2001
42
Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes. (10482045)
1999
43
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
44
Solving riddles of glycosphingolipids: analyses of sphingolipid functions by a glucosylceramide synthase-deficient mutant]. (9883649)
1998
45
Differential expression of cell proliferation regulatory proteins in B- and T-lineage acute lymphoblastic leukaemias. (8943894)
1996
46
Identification of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma: a combined in vitro and in vivo analysis. (7761101)
1995
47
The oesophagus and stomach of the African elephant: a histological, immunocytochemical and immunofluorescence study. (7596575)
1994
48
Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes. (8049160)
1994
49
Torsion of cavernous lymphangioma: an unusual cause of acute scrotum. (2810511)
1989
50
Gold neurotoxicity and myokymia. (3379631)
1988

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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GO Terms for genes affiliated with Varicocele

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Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glutathione metabolic processGO:000674910.2GSTM1, GSTT1
2muscle cell cellular homeostasisGO:004671610.1HIF1A, IL6
3response to coldGO:000940910.0HSPA2, IL6
4response to auditory stimulusGO:001099610.0HIF1A, IL6
5response to glucocorticoidGO:00513849.6CASP3, HIF1A, IL6
6response to antibioticGO:00466779.5CASP3, IL6, TP53
7response to lipopolysaccharideGO:00324969.1CASP3, GNRH1, IL6
8cellular response to DNA damage stimulusGO:00069748.9CASP3, PARP1, TP53
9response to organic cyclic compoundGO:00140708.8AMH, CASP3, IL6
10positive regulation of gene expressionGO:00106288.7AMH, HIF1A, IL6, TP53
11negative regulation of apoptotic processGO:00430668.1ALB, CASP3, GNRH1, HIF1A, IL6, TP53
12positive regulation of transcription from RNA polymerase II promoterGO:00459447.8CGA, HIF1A, IL6, PARP1, TP53

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.4ALB, TP53

Sources for Varicocele

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet