MCID: VRC001
MIFTS: 49

Varicocele malady

Cardiovascular category

Summaries for Varicocele

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Varicocele /ˈværɨkɵsiːl/ is an abnormal enlargement of the pampiniform venous plexus in the... more...

MalaCards: Varicocele, also known as scrotal varices, is related to infertility and azoospermia. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Glycoprotein hormones and Nongenotropic Androgen signaling. The compounds estrogen and 11 deoxycortisol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Varicocele

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

varicocele 8 10 45 61
scrotal varices 8


External Ids:

Disease Ontology8 DOID:12337
ICD9CM27 456.4
MeSH35 D014646
ICD1025 I86.1

Related Diseases for Varicocele

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.1SHBG, AZF1, GNRH1, USP9Y, CGA, PRL
2azoospermia30.7ACPP, GNRH1, AMH, AZF1, USP9Y, SHBG
3oligospermia30.5AZF1, AMH, GNRH1, USP9Y, CGA, CGB5
4cryptorchidism30.2CGB5, CGA, SHBG, AZF1, AMH, GNRH1
5gynecomastia30.1PRL, GNRH1, CGA, CGB5, SHBG
6klinefelter's syndrome29.8AZF1, GNRH1, CGA, PRL, SHBG
7hypoxia10.3
8n syndrome10.3
9varicose veins10.2
10ankylosing spondylitis10.1
11angiokeratoma10.1
12spondylitis10.1
13turner syndrome10.0GNRH1
14diabetes insipidus10.0PRL
15insulin resistance10.0SHBG
16systemic lupus erythematosus10.0PRL
17hermaphroditism10.0AMH
18obesity10.0SHBG
19hypogonadotropism10.0GNRH1, PRL
20prostatitis10.0ACPP
21peritonitis10.0AQP1
22mccune albright syndrome10.0GNRH1
23cushing's syndrome10.0PRL
24prostatic hypertrophy10.0GNRH1, ACPP
25thyroiditis10.0CGA
26pseudohermaphroditism10.0AMH
27seminoma10.0CGA, CGB5
28penile disease10.0GNRH1, PRL
29hypothalamic disease10.0GNRH1, PRL, CGA
30sexual disorder10.0SHBG, PRL, GNRH1
31germinoma10.0CGB5, CGA
32prolactinoma10.0GNRH1, PRL, CGA
33teratoma10.0CGB5, CGA
34ovarian hyperstimulation syndrome10.0GNRH1, CGA, CGB5
35premature ovarian failure10.0GNRH1, SHBG, PRL
36dysgerminoma10.0CGA, CGB5
37abrikosov's tumor10.0AMH, GNRH1, CGA
38ovarian cyst10.0CGB5, CGA, GNRH1
39leydig cell tumor10.0GNRH1, CGA, CGB5
40hypogonadism, hypergonadotropic10.0PRL, SHBG
41acromegaly10.0PRL, SHBG, GNRH1
42ovarian disease10.0SHBG, GNRH1, PRL, CGA
43pregnancy loss10.0CGA, CGB5, GNRH1
44pituitary adenoma10.0GNRH1, CGA, PRL
45hypopituitarism10.0GNRH1, CGA, SHBG, PRL
46hypospadias10.0CGA
47neurogenic diabetes insipidus10.0GNRH1, PRL
48placental site trophoblastic tumor10.0CGA, CGB5
49amenorrhea10.0GNRH1, PRL, SHBG, AMH
50penis agenesis10.0GNRH1, CGA

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Clinical Features for Varicocele

Drugs & Therapeutics for Varicocele

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Varicocele

Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Search CenterWatch for Varicocele

Genetic Tests for Varicocele

Anatomical Context for Varicocele

Sources:
33MalaCards
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MalaCards organs/tissues related to Varicocele:

33
Brain, Spinal cord, Smooth muscle, Colon, Kidney, Prostate, Testis, T cells, B cells, Endothelial, Pituitary, Testis germ, Testis leydig

Animal Models for Varicocele or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Varicocele:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8HSPA2, HSF2, AMH, GNRH1, CGA, PRL
2MP:00053899.4HSPA2, HSF2, AMH, GNRH1, CGA, PRL

Publications for Varicocele

Sources:
51PubMed
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Articles related to Varicocele:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Varicocele and value based health care. (23485504)
2013
2
Surgical management of nutcracker phenomenon presenting as left varicocele in adolescents: A novel approach. (24206783)
2013
3
Varicocele and hypogonadism. (23754533)
2013
4
Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study. (23964789)
2013
5
Idiopathic varicocele in adolescents: risks of the inguinal approach. (23487306)
2013
6
The adolescent varicocele--a Shakespearean tragedy or much ado about nothing? (23500035)
2013
7
Laparoendoscopic Single-Site Surgery with a Single Channel Versus Conventional Laparoscopic Varicocele Ligation: A Prospective Randomized Study. (23961951)
2013
8
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
9
Contemporary issues in varicocele management. (22965320)
2012
10
Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. (22177844)
2012
11
The hemodynamic approach to evaluating adolescent varicocele. (22450604)
2012
12
Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders. (22747653)
2012
13
Varicocele repair for low testosterone. (23026894)
2012
14
A critical appraisal on the role of varicocele in male infertility. (22162682)
2012
15
Biochemical alterations in semen of varicocele patients: a review of the literature. (21915179)
2012
16
Laparoendoscopic single-site surgery versus conventional laparoscopic varicocele ligation in men with palpable varicocele: a randomized, clinical study. (22083325)
2012
17
Differential clustering of sperm subpopulations in infertile males with clinical varicocele and carriers of rearranged genomes. (21835912)
2012
18
Potential role of prokineticin 2 in experimental varicocele-induced rat testes. (22840859)
2012
19
Effects of anthocyanin extracted from black soybean seed coat on spermatogenesis in a rat varicocele-induced model. (22697115)
2012
20
Re: Bozkurt et al.: relationship between mean platelet volume and varicocele: a preliminary study (Urology 2012:79:1048-1051). (22925260)
2012
21
Comparative study of gene expression in patients with varicocele by microarray technology. (21848884)
2012
22
Expression of E-cadherin and I+-catenin in a varicocele-induced infertility rat model. (21399649)
2011
23
Intraabdominal laparoscopy-assisted "open" vessel ligation of testicular vessels: a potential treatment for varicocele. (21819214)
2011
24
Re: Sperm chromatin condensation in infertile men with varicocele before and after surgical repair. (21993123)
2011
25
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
26
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
27
Expression of the Fas-ligand gene in ejaculated sperm from adolescents with and without varicocele. (20165911)
2010
28
The effect of prior varicocelectomy in patients with nonobstructive azoospermia on intracytoplasmic sperm injection outcomes: a retrospective pilot study. (19913887)
2010
29
The effect of the partial obstruction site of the renal vein on testis and kidney in rats: is the traditional animal model suitable for varicocele research? (20733964)
2010
30
The role of testicular volume in adolescents with varicocele: the better way and time of surgical treatment. (20728113)
2010
31
Experimental varicocele induces p53-dependent germ cell apoptosis through activation of I^-H2AX. (20530960)
2010
32
Pentoxifylline and antioxidants improve sperm quality in male patients with varicocele. (18990381)
2009
33
Preoperative and postoperative seminal nitric oxide levels in patients with infertile varicocele. (20608151)
2009
34
Laparoscopic Palomo varicocele surgery: lessons learned after 10 years' follow up of 156 consecutive pediatric patients. (19083272)
2009
35
Results and complications of adolescent varicocele repair with intraoperative sodium morrhuate sclerotherapy. (18721963)
2008
36
Painful varicocele in pediatric age: is there a correlation between pain, testicular damage and hormonal values to justify surgery? (18797882)
2008
37
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
38
Increased testicular 8-hydroxy-2'-deoxyguanosine in patients with varicocele. (17559562)
2007
39
Re: Derya Tilki, Ergin Kilic, Robert Tauber, Dietrich Pfeiffer, Christian G. Stief, Roland Tauber and SA1leyman ErgA1n. The complex structure of the smooth muscle layer of spermatic veins and its potential role in the development of varicocele testis. Eur Urol 2007;51:1402-10. (17560015)
2007
40
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
41
Intratesticular varicocele and extratesticular varicocele in a patient with nephrotic syndrome complicated by left renal vein thrombosis. (16861853)
2006
42
Report on varicocele and infertility. (17055852)
2006
43
Cytosolic calcium levels in spermatozoa are modulated differently in healthy subjects and patients with varicocele. (16412745)
2006
44
Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele. (15878918)
2005
45
The use of isosulphan blue to identify lymphatic vessels in high retroperitoneal ligation of adolescent varicocele--avoiding postoperative hydrocele. (11298043)
2001
46
Leydig cell function in experimental cryptorchism and varicocele in rats]. (10390949)
1999
47
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
48
The value of the gonadotrophin-releasing hormone test as a prognostic factor in infertile patients with varicocele. (8944523)
1996
49
Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction. (8911364)
1996
50
Indices of testicular endosecretory function and of the status of the hypophyseal-gonadal system in varicocele]. (2368218)
1990

Genetic Variations for Varicocele

Expression for genes affiliated with Varicocele

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Varicocele according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GNRH1, CGA
210.3SHBG, GNRH1
3
Hide members
10.3BLVRB, HMOX2
4
Hide members
10.3BLVRB, HMOX2
510.3BLVRB, ACPP

Compounds for genes affiliated with Varicocele

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7HSF2, ACPP
211 deoxycortisol4510.6SHBG, CGA, PRL
3estradiol benzoate4510.6CGB5, GNRH1, PRL, CGA
4leuprolide45 60 29 1113.6GNRH1, PRL, CGB5, CGA
5goserelin45 29 1112.6ACPP, GNRH1, SHBG, CGA
6metoclopramide45 1111.6GNRH1, PRL, CGA
7cyproteroneacetate4510.6GNRH1, PRL, SHBG, ACPP
8bromocriptine29 45 1112.6GNRH1, CGA, SHBG, PRL
9flutamide45 60 1112.6SHBG, GNRH1, CGA, ACPP, PRL
1017-hydroxypregnenolone4510.6SHBG, CGB5, CGA, ACPP
11toremifene45 1111.5SHBG, PRL, GNRH1
12leuprolide acetate4510.5GNRH1, CGA, CGB5, PRL, SHBG
13cetrorelix45 29 1112.5CGB5, CGA, GNRH1
14clomiphene citrate4510.5PRL, CGB5, CGA, GNRH1, SHBG
15buserelin45 29 1112.5ACPP, CGB5, PRL, CGA, GNRH1
16dopamine45 29 11 2413.5BLVRB, HMOX2, GNRH1, SHBG
17naloxone45 50 29 1113.5GNRH1, CGB5, PRL, CGA
18danazol45 11 2412.5GNRH1, SHBG, PRL
19altrenogest4510.5CGA, GNRH1
20percoll4510.5ACR, CGB5, CGA, LDHC
21cabergoline29 45 1112.5PRL, GNRH1, CGA
22progestin4510.5CGB5, GNRH1, PRL, SHBG, CGA
23diethylstilbestrol45 29 1112.5GNRH1, CGB5, SHBG, ACPP, CGA
2417-hydroxyprogesterone45 2411.5SHBG, GNRH1, ACPP, CGA, CGB5, PRL
25dehydroepiandrosterone sulfate4510.5CGB5, PRL, CGA, GNRH1, ACPP, SHBG
26mifepristone45 60 29 1113.5AMH, GNRH1, CGA, CGB5, PRL, SHBG
27dhea4510.5ACPP, CGB5, PRL, SHBG
28androstenedione45 2411.5CGB5, GNRH1, PRL, CGA, ACPP, SHBG
29gnrh4510.4BLVRB, INHBB, ACPP, CGA, GNRH1, SHBG
3011-ketotestosterone4510.4CGA, CGB5
31metrodin4510.4CGA, GNRH1
32estrone45 29 11 2413.4GNRH1, CGB5, PRL, SHBG
33dihydrotestosterone45 29 11 2413.4CGA, ACPP, CGB5, GNRH1, PRL, SHBG
34sodium nitroprusside4510.4AQP1, GNRH1, CGA, BLVRB, CGB5
35acth4510.4PRL, ACPP, SHBG, CGB5, GNRH1
36epinephrine45 11 2412.4GNRH1, CGB5, PRL, SHBG, CGA
37tamoxifen45 50 29 1113.4SHBG, PRL, CGA, CGB5, AMH, GNRH1
38ribonucleic acid4510.4GNRH1, CGA, CGB5, PRL, HMOX2
39deslorelin4510.4GNRH1, CGA
40estradiol45 11 2412.3ACPP, BLVRB, SHBG, PRL, CGB5, CGA
41pergonal4510.3CGA, GNRH1
42lactate4510.2GNRH1, LDHC, ACR, ACPP, CGA, GLA
43creatinine4510.2AQP1, LDHC, ACPP, GLA, SHBG, CGB5
44steroid4510.2SHBG, GNRH1, CGB5, CGA, BLVRB, ACPP
45progesterone45 60 29 11 2414.2BLVRB, HMOX2, ACPP, CGB5, SHBG, PRL
46adenylate4510.2BLVRB, CGA, CGB5, SHBG, NT5E, GNRH1
47testosterone45 60 11 2413.2CGB5, LDHC, ACPP, CGA, BLVRB, SHBG
48norepinephrine45 11 2412.1GNRH1, CGA, CGB5, SHBG, PRL
49arginine4510.0SHBG, ACR, ACPP, HMOX2, GLA, BLVRB
50(+-)-pgf2-alpha459.9GNRH1, CGA, CGB5

GO Terms for genes affiliated with Varicocele

Sources:
16Gene Ontology
See all sources

Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8ACR, ACPP, INHBB, GLA, SHBG, PRL

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.3HMOX2, BLVRB
2heme catabolic processGO:04216710.2HMOX2, BLVRB
3ovulation cycleGO:04269810.0PRL, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.1SHBG, GLA, INHBB, ACPP, HSF2
2hormone activityGO:0051799.8INHBB, PRL, CGA, GNRH1, AMH

Products for genes affiliated with Varicocele

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  • Proteins
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  • Antibodies

Sources for Varicocele

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet