Aliases & Classifications for Varicocele

MalaCards integrated aliases for Varicocele:

Name: Varicocele 12 28 51 41 14 69
Scrotal Varices 12
Varicoceles 59

Classifications:



External Ids:

Disease Ontology 12 DOID:12337
ICD10 32 I86.1
ICD9CM 34 456.4
MeSH 41 D014646
UMLS 69 C0042341

Summaries for Varicocele

PubMed Health : 59
About varicoceles: Varicoceles are varicose veins in the scrotum. They form in the veins that run along the spermatic cord. Blood from the testicles flows back into the body through those veins. Like varicose veins in the legs, varicoceles form when blood builds up in the veins and they become permanently enlarged.

MalaCards based summary : Varicocele, also known as scrotal varices, is related to oligospermia and varicose veins, and has symptoms including pain in scrotum An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Pathways in cancer. The drugs Ginseng and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

Related Diseases for Varicocele

Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 oligospermia 30.6 GSTM1 GSTT1 PRL
2 varicose veins 30.2 CASP9 HIF1A SHBG
3 gynecomastia 30.1 CGA PRL SHBG
4 impotence 29.3 NOS2 NOS3 PRL SHBG
5 cryptorchidism, unilateral or bilateral 29.2 AMH AZF1 CGA GNRH1 SHBG
6 ischemia 28.8 CASP3 HIF1A NOS2 NOS3
7 spermatocele 11.0
8 infertility 10.7
9 pituitary infarct 10.5 GNRH1 PRL
10 endometriosis of uterus 10.5 GNRH1 PRL
11 hypogonadotropism 10.5 GNRH1 PRL
12 hypothalamic disease 10.5 GNRH1 PRL
13 hearing loss, noise-induced 10.5 GSTM1 GSTT1
14 chiasmal syndrome 10.5 GNRH1 PRL
15 sister chromatid exchange, frequency of 10.4 GSTM1 GSTT1
16 pituitary apoplexy 10.4 GNRH1 PRL
17 penis agenesis 10.4 CGA GNRH1
18 isolated cleft lip 10.4 GSTM1 GSTT1
19 empty sella syndrome 10.4 GNRH1 PRL
20 prostatic adenoma 10.4 PRL SHBG
21 nodular prostate 10.3 GNRH1 HIF1A
22 premenstrual tension 10.3 GNRH1 PRL SHBG
23 hyperandrogenism 10.3 GNRH1 PRL SHBG
24 amenorrhea 10.3 GNRH1 PRL SHBG
25 pelvic varices 10.3 GNRH1 SHBG
26 oral leukoplakia 10.3 GSTM1 GSTT1
27 hyperthyroidism 10.3 CGA PRL SHBG
28 male infertility 10.2
29 azoospermia 10.2
30 endometriosis 10.2 GNRH1 GSTM1 GSTT1
31 testicular cancer 10.2 AZF1 CGA SHBG
32 toxic encephalopathy 10.2 CASP3 GSTM1 GSTT1
33 aging 10.2
34 episodic pain syndrome, familial, 1 10.2
35 freemartinism 10.2 AMH GNRH1
36 oral cancer 10.2 CASP3 GSTM1 GSTT1
37 male reproductive organ cancer 10.2 CASP3 GNRH1 SHBG
38 internal hemorrhoid 10.2 CASP3 NOS2
39 polycystic ovary syndrome 10.2 GNRH1 PRL SHBG
40 platelet membrane fluidity 10.2 NOS2 NOS3
41 anovulation 10.1 CGA GNRH1 PRL SHBG
42 prostatitis 10.1
43 cerebral hypoxia 10.1 CASP3 CASP9
44 body mass index quantitative trait locus 1 10.1
45 arteritic anterior ischemic optic neuropathy 10.1 GSTM1 GSTT1 NOS3
46 ischemic optic neuropathy 10.1 GSTM1 GSTT1 NOS3
47 sexual disorder 10.1 NOS3 PRL SHBG
48 hypoxia 10.1
49 ovarian hyperstimulation syndrome 10.1 AMH CGA GNRH1
50 testicular disease 10.1 CASP3 CGA NOS3

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to Varicocele

Symptoms & Phenotypes for Varicocele

UMLS symptoms related to Varicocele:


pain in scrotum

MGI Mouse Phenotypes related to Varicocele:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 AMH CASP3 CASP9 CGA GNRH1 HIF1A
2 reproductive system MP:0005389 9.28 AMH CASP3 CGA GNRH1 HSPA2 NOS2

Drugs & Therapeutics for Varicocele

PubMedHealth treatment related to Varicocele: 59

Varicoceles do not normally need to be treated. But some experts do suggest treatment for men who have fertility problems and a varicocele, in the hope that it will improve fertility.The treatment involves “shutting down” the affected vein so that the blood flows through healthy, neighboring veins instead. This can be done by blocking the vein using minimally-invasive procedures (embolization) or by performing varicose vein surgery. In embolization, the affected vein is blocked using a catheter to inject either a solution that causes scarring (sclerotherapy), a tissue adhesive, or a detachable balloon or coil. In surgery, the swollen vein and the surrounding smaller veins are either cut or tied.

Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
2
Methylene blue Approved, Investigational Phase 2 61-73-4
3
Papaverine Approved, Investigational 58-74-2, 61-25-6 4680
4
Sodium Tetradecyl Sulfate Approved, Investigational 139-88-8, 1191-50-0 5248 14492
5 Tocopherol Approved, Investigational, Nutraceutical
6
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
7 Androgens
8 Estrogens
9 Hormone Antagonists
10 Hormones
11 Hormones, Hormone Substitutes, and Hormone Antagonists
12 Tocopherols
13 Tocotrienols
14 Vitamins
15 Vaccines
16 Anesthetics
17 Analgesics
18 Anesthetics, Local
19 Anti-Infective Agents, Local
20 Central Nervous System Depressants
21 Follicle Stimulating Hormone
22 Anti-Inflammatory Agents
23 Tocotrienol Investigational, Nutraceutical 6829-55-6

Interventional clinical trials:

(show all 31)

# Name Status NCT ID Phase Drugs
1 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
2 The Role of Microsurgery in Surgical Treatment of Varicocele. Unknown status NCT02722187 Phase 4
3 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
4 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4 Korean Red Ginseng, Varicocelectomy;Placebo
5 Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis Terminated NCT00767338 Phase 3
6 Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy Completed NCT01259258 Phase 2
7 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
8 The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analisy Unknown status NCT02401087
9 Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE Unknown status NCT02033863
10 Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities Unknown status NCT02695199
11 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
12 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
13 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
14 Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility Completed NCT02006316
15 The Effect of Spermatic Vein Embolization on Prostatic Hypertrophy Completed NCT00639899
16 Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate Cancer Completed NCT00637208
17 Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy Completed NCT02092311
18 Single Incision Laparoscopic Varicocelectomy Completed NCT02335385
19 Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine Completed NCT02983656
20 Varicocelectomy To Treat Pain, Predictors Of Success Completed NCT01395186
21 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. Completed NCT03344588
22 Effect of TAP Block for Postoperative Pain Control After Varicocele Operations. Recruiting NCT02983383
23 The Search for Viral and Bacterial Etiology of Varicocele Recruiting NCT03079609
24 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
25 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548
26 IVF Outcomes After Varicocele Repair Not yet recruiting NCT03090438
27 Varicocele Treatement by Endovasculer Embolization Not yet recruiting NCT03341897
28 the Effect of Different Modialites of Varicocelectomy on Semen Parameters in Patient With Normal Semen Analysis Not yet recruiting NCT03281915
29 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Not yet recruiting NCT03477149 Not Applicable
30 Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy Terminated NCT00961558
31 Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality? Terminated NCT01296230

Search NIH Clinical Center for Varicocele

Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

Genetic tests related to Varicocele:

# Genetic test Affiliating Genes
1 Varicocele 28

Anatomical Context for Varicocele

MalaCards organs/tissues related to Varicocele:

38
Testis, Testes, Prostate, Endothelial, Kidney, Smooth Muscle, Pituitary

Publications for Varicocele

Articles related to Varicocele:

(show top 50) (show all 704)
# Title Authors Year
1
Effect of varicocelectomy and/or mast cells stabilizer on sperm DNA fragmentation in infertile patients with varicocele. ( 29195028 )
2018
2
Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology. ( 29051002 )
2018
3
Thiol-disulphide homoeostasis as an oxidative stress marker in men with varicocele. ( 29411889 )
2018
4
Varicocele Due to Post Traumatic Arteriovenous Fistula. ( 29432872 )
2018
5
Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1I+ (p-IRE1I+) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways. ( 29316840 )
2018
6
LncRNA gadd7, increased in varicocele patients, suppresses cell proliferation and promotes cell apoptosis. ( 29435165 )
2018
7
Response to Pelvic venous reflux in male: Varicocele? ( 29316851 )
2018
8
Bilateral is superior to unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a prospective randomized controlled study. ( 29210007 )
2018
9
Berberine inhibits experimental varicocele-induced cell cycle arrest via regulating cyclin D1, cdk4 and p21 proteins expression in rat testicles. ( 29441600 )
2018
10
Varicocele due to renal arteriovenous malformation mimicking a renal tumor: a case report. ( 29304872 )
2018
11
The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats. ( 29387197 )
2018
12
Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study. ( 29315686 )
2018
13
Comparison of The Efficacy and Safety of Palomo, Ivanissevich and Laparoscopic Varicocelectomy in Iranian Infertile Men with Palpable Varicocele. ( 29334212 )
2018
14
Historical investigations into varicocele pathophysiology and sperm migration. ( 29274657 )
2018
15
Two decades of experience with laparoscopic varicocele repair in children: Standardizing the technique. ( 28807743 )
2017
16
Pressure flow pattern of varicocele veins and its correlation with testicular blood flow and semen parameters. ( 28766734 )
2017
17
Y chromosome microdeletions and varicocele as aetiological factors of male infertility: A cross-sectional study. ( 29265486 )
2017
18
Back pain after varicocele embolization. ( 28678015 )
2017
19
Re: Sperm Concentration and Forward Motility are Not Correlated with Age inA Adolescents with an Idiopathic Varicocele and Symmetrical Testicular Volumes. ( 28817895 )
2017
20
The Role of Varicocele in Male Factor Subfertility. ( 28718159 )
2017
21
Varicocele and male infertility. ( 28675168 )
2017
22
Comparative Expression Analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor Gene between Varicocele-Induced and Non-Varicocele Testes of Dog. ( 28868836 )
2017
23
Update on the novel management and future paternity situation in adolescents with varicocele. ( 28861292 )
2017
24
Randomised clinical trial of comparing effects of acupuncture and varicocelectomy on sperm parameters in infertile varicocele patients. ( 28083932 )
2017
25
The intriguing role of VEGF in varicocele. ( 28741722 )
2017
26
The Tricuspid Insufficiency-Pulsating Varicocele Connection: A Syndrome and Its History. ( 29259498 )
2017
27
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. ( 29410731 )
2017
28
Pelvic venous reflux in male: Varicocele? ( 29212416 )
2017
29
Roles of Fas/FasL-mediated apoptosis and inhibin B in the testicular dysfunction of rats with left-side varicocele. ( 28722192 )
2017
30
Evaluation of Thermal Imaging System of the Scrotum in Patients with Varicocele. ( 29259952 )
2017
31
A review of varicocele repair for pain. ( 28725614 )
2017
32
Microsurgical varicocelectomy for clinical varicocele: A review for potential new indications. ( 28671268 )
2017
33
Treatment of varicocele in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. ( 28851509 )
2017
34
Re: Increased Body Mass Index in Men with Varicocele is Associated with Larger Spermatic Vein Diameters when Supine. ( 27979554 )
2017
35
<i>Morinda Officinalis</i> Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression. ( 29234440 )
2017
36
Back pain after varicocele embolization. ( 28678016 )
2017
37
The varicocele as related to fertility. ( 27842996 )
2017
38
Unilateral angiokeratoma of the scrotum (Fordyce's type) associated with a contralateral varicocele. ( 28540880 )
2017
39
Obstructive azoospermia caused by low ligation of varicocele: A case report. ( 28771041 )
2017
40
Autophagy may play an important role in varicocele. ( 28849201 )
2017
41
Varicocele and semen quality: a retrospective case-control study of 4230 patients from a single centre. ( 28647897 )
2017
42
Therapeutic efficacy and safety of laparoscopic surgery versus microsurgery for varicocele of adult males: A meta-analysis. ( 28834886 )
2017
43
Varicocele ( 28846314 )
2017
44
Left-Sided Varicocele as a Rare Presentation of May-Thurner Syndrome. ( 28258018 )
2017
45
Uterine Arteriovenous Fistula with Concomitant Pelvic Varicocele: Endovascular Embolization with Onyx-18Ar. ( 29359062 )
2017
46
Studies on Varicocele and Subfertility - an Ongoing Debate. ( 28657387 )
2017
47
Re: Varicocele Negatively Affects Sperm Mitochondrial Respiration. ( 27191106 )
2016
48
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. ( 27595632 )
2016
49
Laparoendoscopic single-site surgery varicocelectomy versus conventional laparoscopic varicocele ligation: A meta-analysis. ( 27688686 )
2016
50
Who will benefit from surgical repair for painful varicocele: a meta-analysis. ( 27074742 )
2016

Variations for Varicocele

Expression for Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for Varicocele

Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CASP3 CASP9 CGA GNRH1
2 12.46 CASP3 CASP9 GSTM1 GSTT1 HIF1A NOS2
3
Show member pathways
12.17 CASP3 CGA NOS2 NOS3 PRL
4
Show member pathways
11.94 CASP3 CASP9 HSPA2 NOS2
5 11.89 GSTM1 GSTT1 NOS3
6
Show member pathways
11.88 CASP3 CASP9 PLCZ1
7 11.8 CASP9 HIF1A PLCZ1
8 11.77 CASP3 CASP9 PLCZ1
9 11.72 HIF1A NOS2 NOS3
10 11.65 CASP3 CASP9 NOS3
11 11.64 CASP3 CASP9 NOS2
12
Show member pathways
11.57 CASP3 CASP9 NOS3
13
Show member pathways
11.38 HSPA2 NOS2 NOS3
14 11.32 CASP3 CASP9 HSPA2
15 11.32 CASP3 CASP9 GSTM1 GSTT1
16 10.99 HIF1A NOS3
17 10.98 NOS2 NOS3
18 10.97 GSTM1 GSTT1
19 10.96 CASP3 CASP9 HIF1A NOS2
20 10.95 CASP3 CASP9
21 10.84 CASP3 CASP9 HIF1A NOS2 NOS3
22 10.82 GNRH1 SHBG
23 10.65 CGA GNRH1
24 10.64 NOS2 NOS3
25 10.36 NOS2 NOS3

GO Terms for Varicocele

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood vessel diameter GO:0097755 9.54 NOS2 NOS3
2 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.52 HIF1A PRL
3 glutathione derivative biosynthetic process GO:1901687 9.51 GSTM1 GSTT1
4 platelet formation GO:0030220 9.49 CASP3 CASP9
5 nitric oxide mediated signal transduction GO:0007263 9.48 NOS2 NOS3
6 nitric oxide biosynthetic process GO:0006809 9.46 NOS2 NOS3
7 response to lipopolysaccharide GO:0032496 9.46 CASP3 CASP9 GNRH1 NOS2
8 gonad development GO:0008406 9.43 AMH CGA
9 positive regulation of guanylate cyclase activity GO:0031284 9.4 NOS2 NOS3
10 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.37 CASP3 CASP9
11 arginine catabolic process GO:0006527 9.32 NOS2 NOS3
12 response to cobalt ion GO:0032025 9.26 CASP3 CASP9
13 glial cell apoptotic process GO:0034349 8.96 CASP3 CASP9
14 response to organic cyclic compound GO:0014070 8.92 AMH CASP3 CASP9 GNRH1

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 FMN binding GO:0010181 9.4 NOS2 NOS3
2 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP3 CASP9
3 arginine binding GO:0034618 9.32 NOS2 NOS3
4 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS2 NOS3
5 tetrahydrobiopterin binding GO:0034617 9.16 NOS2 NOS3
6 nitric-oxide synthase activity GO:0004517 8.96 NOS2 NOS3
7 hormone activity GO:0005179 8.92 AMH CGA GNRH1 PRL

Sources for Varicocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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