MCID: VRC001
MIFTS: 48

Varicocele malady

Cardiovascular diseases category

Summaries for Varicocele

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Wikipedia:65 A varicocele /?v more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to infertility and male infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Hormone ligand-binding receptors and Glucocorticoid receptor regulatory network. The compounds deslorelin and pergonal have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Varicocele

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 27ICD10
See all sources

Varicocele, Aliases & Descriptions:

Name: Varicocele 10 12 45 62
 
Scrotal Varices 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:12337
ICD9CM29 456.4
MeSH35 D014646
ICD1027 I86.1

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.3AZF1, SHBG, GNRH1, CGA, PRL, AMH
2male infertility30.8GNRH1, PRL, SHBG
3azoospermia30.6ACPP, CGA, AZF1, GNRH1, SHBG, AMH
4oligospermia30.5GNRH1, AMH, PRL, CGA, AZF1
5cryptorchidism30.2AZF1, SHBG, AMH, CGA, GNRH1
6impotence30.1SHBG, PRL
7gynecomastia30.1SHBG, PRL, CGA, GNRH1
8hypogonadism29.9CGA, PRL, SHBG, GNRH1
9klinefelter's syndrome29.8PRL, GNRH1, CGA, SHBG, AZF1
10prostatitis10.4
11hypoxia10.4
12hydrocele10.3
13varicose veins10.2
14endotheliitis10.2
15renal cell carcinoma10.1
16hepatitis10.1
17angiokeratoma10.1
18constipation10.1
19nephrotic syndrome10.1
20spondylitis10.1
21mccune-albright syndrome, somatic, mosaic10.1GNRH1
22hermaphroditism10.0AMH
23penis agenesis10.0GNRH1, CGA
24ovarian cyst10.0GNRH1, CGA
25ovarian hyperstimulation syndrome10.0GNRH1, CGA
26prostatic hypertrophy10.0ACPP, GNRH1
27penile disease10.0PRL, GNRH1
28hypogonadotropism10.0GNRH1, PRL
29kallmann syndrome10.0GNRH1, CGA
30diabetes insipidus, neurohypophyseal10.0PRL, GNRH1
31pituitary apoplexy10.0PRL, GNRH1
32pituitary gland disease10.0PRL, GNRH1
33leydig cell tumor10.0CGA, GNRH1
34premature ovarian failure10.0GNRH1, AMH
35androgen insensitivity10.0SHBG, CGA
36turner syndrome10.0CGA, SHBG
37hypothyroidism10.0CGA, SHBG
38hyperinsulinism10.0SHBG, GNRH1
39uterine fibroid10.0SHBG, GNRH1
40cushing's syndrome10.0GNRH1, PRL
41hypothalamic disease10.0PRL, GNRH1, CGA
42abrikosov's tumor10.0CGA, GNRH1, AMH
43pituitary tumors10.0GNRH1, PRL
44hypoglycemia10.0PRL, GNRH1
45prolactinoma10.0PRL, GNRH1, CGA
46pituitary adenoma10.0GNRH1, CGA, PRL
47non-suppurative otitis media10.0ACPP, SHBG
48testicular cancer10.0SHBG, AZF1, CGA
49anorexia nervosa10.0PRL, SHBG
50sexual disorder10.0GNRH1, PRL, SHBG

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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Drugs & Therapeutics for Varicocele

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Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

33
Testis, Testes, Prostate, Kidney, Smooth muscle, Endothelial, Pituitary, Brain, Spinal cord, Colon

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0INHBB, GNRH1, PRL, ACPP
2MP:00053797.8CGA, PRL, AMH, GNRH1, INHBB
3MP:00053767.8CGA, PRL, AMH, GNRH1, INHBB
4MP:00053897.7INHBB, GNRH1, AMH, PRL, CGA

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
2
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
3
Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study. (25405715)
2014
4
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele. (25179750)
2014
5
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
6
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
7
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
8
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
9
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
10
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
11
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
12
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
13
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
14
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
15
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
16
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
17
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
18
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
19
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
20
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
21
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
22
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
23
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
24
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
25
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
26
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
27
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
28
Testicular varicocele: an overview. (19506401)
2009
29
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
30
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
31
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
32
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
33
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
34
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
35
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
36
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
37
The treatment of adolescents presenting with a varicocele. (17822454)
2007
38
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
39
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
40
Antisperm antibodies and varicocele. (16466113)
2006
41
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
42
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
43
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
44
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
45
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
46
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
47
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
48
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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Compounds for genes affiliated with Varicocele

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Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1deslorelin4510.0GNRH1, CGA
2pergonal4510.0GNRH1, CGA
3metrodin4510.0GNRH1, CGA
4altrenogest4510.0CGA, GNRH1
5antarelix45 3010.9CGA, GNRH1
6ganirelix45 3010.9CGA, GNRH1
7d-trp6-lhrh459.8CGA, GNRH1
8epitestosterone459.7SHBG, CGA
9estradiol benzoate459.6CGA, GNRH1, PRL
10leuprolide45 61 30 1312.6PRL, CGA, GNRH1
11cabergoline45 30 1311.5PRL, GNRH1, CGA
12metoclopramide45 51 1311.5GNRH1, CGA, PRL
13naloxone45 30 51 1312.4GNRH1, PRL, CGA
14chlormadinone acetate459.4ACPP, SHBG
1517-hydroxypregnenolone459.4SHBG, ACPP, CGA
16toremifene45 1310.3SHBG, GNRH1, PRL
17danazol45 26 1311.3SHBG, PRL, GNRH1
18opiate459.3CGA, PRL, GNRH1
1911 deoxycortisol459.3PRL, CGA, SHBG
20metformin45 51 1311.3GNRH1, SHBG, CGA
21buserelin45 30 1311.2CGA, PRL, ACPP, GNRH1
22goserelin45 30 1311.1ACPP, CGA, GNRH1, SHBG
23diethylstilbestrol45 30 1311.0CGA, ACPP, GNRH1, SHBG
24dhea459.0ACPP, PRL, SHBG
25leuprolide acetate459.0GNRH1, SHBG, CGA, PRL
26clomiphene citrate459.0CGA, GNRH1, SHBG, PRL
27bromocriptine45 30 1311.0CGA, PRL, SHBG, GNRH1
28progestin458.9SHBG, PRL, CGA, GNRH1
29cyproteroneacetate458.9PRL, SHBG, GNRH1, ACPP
30thyroxine45 269.9SHBG, GNRH1, PRL, CGA
31acth458.8ACPP, PRL, SHBG, GNRH1
32epinephrine45 26 1310.8PRL, CGA, GNRH1, SHBG
33triiodothyronine458.8PRL, SHBG, CGA
34norepinephrine45 26 1310.8SHBG, PRL, GNRH1, CGA
35dopamine45 30 26 1311.5GNRH1, SHBG, CGA, PRL
3617-hydroxyprogesterone45 269.5SHBG, CGA, GNRH1, PRL, ACPP
37flutamide45 61 1310.5SHBG, CGA, PRL, GNRH1, ACPP
38dehydroepiandrosterone sulfate458.5GNRH1, SHBG, PRL, ACPP, CGA
39androstenedione45 269.5PRL, CGA, GNRH1, SHBG, ACPP
40dihydrotestosterone45 30 26 1311.5CGA, ACPP, PRL, SHBG, GNRH1
41mifepristone45 30 61 1311.5PRL, CGA, SHBG, GNRH1, AMH
42tamoxifen45 51 30 1311.4CGA, PRL, SHBG, GNRH1, AMH
43steroid458.4CGA, ACPP, PRL, SHBG, GNRH1
44arginine458.4CGA, PRL, SHBG, GNRH1, ACPP
45lactate458.3GNRH1, CGA, SHBG, ACPP
46estradiol45 26 1310.0ACPP, PRL, AMH, SHBG, GNRH1, CGA
47progesterone45 30 61 26 1312.0ACPP, CGA, PRL, AMH, SHBG, GNRH1
48testosterone45 61 26 1311.0CGA, ACPP, PRL, AMH, SHBG, GNRH1
49estrogen457.9SHBG, AMH, PRL, ACPP, GNRH1, CGA
50gnrh457.7PRL, GNRH1, CGA, SHBG, ACPP, INHBB

GO Terms for genes affiliated with Varicocele

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Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2CGA, PRL, AMH, SHBG, GNRH1, INHBB

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00075659.6PRL, GNRH1
2cell-cell signalingGO:00072678.9CGA, AMH, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051797.8CGA, PRL, AMH, GNRH1, INHBB

Products for genes affiliated with Varicocele

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Sources for Varicocele

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet