Aliases & Classifications for Varicocele

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Aliases & Descriptions for Varicocele:

Name: Varicocele 11 27 50 39 13 68
 
Scrotal Varices 11

Classifications:



External Ids:

Disease Ontology11 DOID:12337
ICD1030 I86.1
ICD9CM32 456.4
MeSH39 D014646

Summaries for Varicocele

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Wikipedia:71 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to hypogonadism and infertility, and has symptoms including pain in scrotum and swelling of scrotum. An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways are Nongenotropic Androgen signaling and Hormone ligand-binding receptors. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are neoplasm and liver/biliary system.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism29.7AMH, PRL, SHBG
2infertility10.6
3mobitz type ii atrioventricular block10.6GNRH1, PRL
4benign prostate phyllodes tumor10.6GNRH1, PRL
5lipid-rich carcinoma10.6GNRH1, PRL
6retinal microaneurysm10.6GNRH1, PRL
7hypothalamic neoplasm10.5GNRH1, PRL
8oral pharyngeal disorders10.5GSTM1, GSTT1
9riedel's fibrosing thyroiditis10.5PRL, SHBG
10hemorrhoid10.4PRL, SHBG
11levic stefanovic nikolic syndrome10.4GSTM1, GSTT1
12orbital cyst10.4GSTM1, GSTT1, PRL
13prolactin producing pituitary tumor10.3GNRH1, PRL, SHBG
14uremia10.3AMH, GNRH1
15benign paroxysmal positional nystagmus10.3GNRH1, PRL, SHBG
16renal-hepatic-pancreatic dysplasia10.3CGA, GNRH1
17chondroma10.2GSTM1, GSTT1, HIF1A
18chronic frontal sinusitis10.2AMH, GNRH1
19ovarian mucinous cystadenocarcinoma10.2CASP3, GSTM1, GSTT1
20cerebellar vermis medulloblastoma10.2CASP3, GNRH1, SHBG
21ovarian hyperstimulation syndrome10.2AMH, CGA, GNRH1
22male infertility10.2
23azoospermia10.1
24asbestosis10.1FASLG, GSTM1, GSTT1
25prostatitis10.1
26elane-related neutropenia10.1CASP9, NOS2
27hypoxia10.0
28oligospermia10.0
29hydrocele9.9
30cervix carcinoma9.9AMH, GNRH1, GSTM1, GSTT1
31dental pulp necrosis9.9AMH, GNRH1, PRL, SHBG
32hidradenitis9.9AMH, GNRH1, PRL, SHBG
33lateral sclerosis9.9AMH, GNRH1, PRL, SHBG
34candidiasis9.9AMH, GNRH1, PRL, SHBG
35pseudopterygium9.9AMH, GNRH1, PRL, SHBG
36precursor b lymphoblastic lymphoma/leukemia9.9AMH, GNRH1, PRL, SHBG
37endotheliitis9.9
38female reproductive organ cancer9.9CASP3, NOS3
39munchausen by proxy9.9NOS3, PRL, SHBG
40hepatitis c9.8NOS3, PRL, SHBG
41lethal congenital contractural syndrome 29.8CASP9, NOS3
42survival motor neuron spinal muscular atrophy9.8NOS3, PRL, SHBG
43cryptorchidism9.8
44inguinal hernia9.8
45spondylitis9.8
46muscular dystrophy-dystroglycanopathy , type a, 29.8CASP3, GNRH1, HIF1A, SHBG
47pleural empyema9.7AMH, CGA, GNRH1, PRL, SHBG
48renal cell carcinoma9.7
49hepatitis9.7
50gynecomastia9.7

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms & Phenotypes for Varicocele

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UMLS symptoms related to Varicocele:


pain in scrotum, swelling of scrotum

MGI Mouse Phenotypes related to Varicocele according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1AMH, FASLG, GNRH1, HIF1A, NOS2, PRL
2MP:00053708.6FASLG, GNRH1, HIF1A, NOS2, NOS3, PRL
3MP:00053818.5CASP3, FASLG, GNRH1, HIF1A, NOS2, NOS3
4MP:00053678.4CASP3, FASLG, GNRH1, HIF1A, NOS2, NOS3
5MP:00053897.3AMH, CASP3, CGA, FASLG, GNRH1, HSPA2
6MP:00053887.3CASP3, CASP9, FASLG, HIF1A, NOS2, NOS3
7MP:00036317.2CASP3, CASP9, CGA, FASLG, GNRH1, HIF1A
8MP:00053796.4AMH, CASP3, CASP9, CGA, FASLG, GNRH1

Drugs & Therapeutics for Varicocele

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Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ginsengapproved, nutraceuticalPhase 49250647-08-0
2
Methylene blueinvestigationalPhase 28161-73-4
Synonyms:
Basic Blue 9
C.I. basic blue 9
Lowacryl blue 9
Methylene blue
Methylene blue anhydrous
Methylthioninium chloride
 
Urolene Blue
aniline violet
methylenium ceruleum
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
Vitamin Eapproved, nutraceutical, vet_approved40659-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Hormones, Hormone Substitutes, and Hormone Antagonists12767
5Hormones13979
6Androgens1275
7Hormone Antagonists12778
8Estrogens2470
9Follicle Stimulating Hormone157
10Tocotrienols402
11Vitamins5095
12Vaccines6428
13Tocopherols406
14Anesthetics, Local3272
15Anesthetics9001
16Anti-Infective Agents, Local1785
17Central Nervous System Depressants12806
18Analgesics11287
19TocopherolNutraceutical406
20TocotrienolNutraceutical402

Interventional clinical trials:

(show all 25)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3The Role of Microsurgery in Surgical Treatment of Varicocele.RecruitingNCT02722187Phase 4
4Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele SurgeryNot yet recruitingNCT02719093Phase 4
5Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
6Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
7Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaUnknown statusNCT02306499
8Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenUnknown statusNCT00150163
9Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
10The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
11Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
12Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
13Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
14Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
15Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
16The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
17Doppler Ultrasound Assisted Varicocelectomy Improve Sperm QualitiesRecruitingNCT02695199
18Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
19The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
20Analysis on AEFI Surveillance Data for Live Attenuated Varicella VaccineActive, not recruitingNCT02983656
21Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
22Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
23Effect of TAP Block for Postoperative Pain Control After Varicocele Operations.Not yet recruitingNCT02983383
24Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
25Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

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Genetic tests related to Varicocele:

id Genetic test Affiliating Genes
1 Varicocele27

Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

36
Testis, Testes, Prostate, Endothelial, Kidney, Smooth muscle, Pituitary

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Randomised clinical trial of comparing effects of acupuncture and varicocelectomy on sperm parameters in infertile varicocele patients. (28083932)
2017
2
Re: Increased Body Mass Index in Men with Varicocele is Associated with Larger Spermatic Vein Diameters when Supine. (27979554)
2017
3
The varicocele as related to fertility. (27842996)
2017
4
Venous Blood Gases of Varicocele Veins: Correlation With Testicular Blood Flow and Semen Quality in Varicocele Patients. (27424121)
2016
5
Neck or groin access for varicocele embolisation: Is it important? (27396460)
2016
6
Testosterone and Varicocele. (27132580)
2016
7
Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. (27423503)
2016
8
Varicocele among infertile men in Qatar. (27401026)
2016
9
Relationship between mean platelet volume, platelet distribution width, plateletcrit and varicocele. (27135841)
2016
10
Prognostic Predictors of Fertility in Young Adult Patients With Varicocele: Peak Retrograde Flow Velocity and Reflux Grade. (27151907)
2016
11
Tracing of zinc and iron in experimentally induced varicocele: correlation with oxidative, nitrosative and carbonyl stress. (27682184)
2016
12
Mean Platelet Volume, Platelet Distribution Width, and Platelet Count in Varicocele: A Systematic Review and Meta-Analysis. (27189836)
2016
13
Editorial Comment to Surgical comparison of subinguinal and high inguinal microsurgical varicocelectomy for adolescent varicocele. (26919278)
2016
14
Who will benefit from surgical repair for painful varicocele: a meta-analysis. (27074742)
2016
15
Dilating venous diseases: Varicocele and varicose vein. (27989727)
2016
16
Aberrant expressions of stem cell factor/c-KIT in rat testis with varicocele. (27707610)
2016
17
Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11 which Forms Inter-Sertoli Tight Junctions in Varicocele Rat Testes. (27164517)
2016
18
First report of a spermatic granuloma and varicocele in a marsupial: A Koala (Phascolarctos cinereus) Case Study. (27473971)
2016
19
The Role of Sonoelastography in the Evaluation of Testes With Varicocele. (27521065)
2016
20
Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. (27526630)
2016
21
Surgical approaches for varicocele in pediatric patient. (27867844)
2016
22
Association between clinical and ultrasonic characteristics of varicocele and lower extremity varicose vein in men. (27531086)
2016
23
Re: Jakob Damsgaard, Ulla N. Joensen, Elisabeth Carlsen, et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.044: Treating varicocele and when to treat? That is the question today and maybe for some time yet. (27641788)
2016
24
Inflammatory and anti-inflammatory cytokines in the seminal plasma of infertile men suffering from varicocele. (27709650)
2016
25
Is varicocele repair necessary, given the advanced state of assisted reproductive technologies? (27056348)
2016
26
An association between sperm PLCIP levels and varicocele? (27612872)
2016
27
Varicocele: tissue stress in the etiology. (27513398)
2016
28
Reply to Eugenio Ventimiglia, Francesco Montorsi, and Andrea Salonia's Letter to the Editor re: Jakob Damsgaard, Ulla N. Joensen, Elisabeth Carlsen, et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.044. (27638092)
2016
29
Clinical Outcomes of Varicocele Repair in Infertile Men: A Review. (27574593)
2016
30
Diagnosis and Management of Pediatric and Adolescent Varicocele: A Survey of Pediatric Urologists in Korea. (27689031)
2016
31
Varicocele: A Review. (27582603)
2016
32
Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele. (28073193)
2016
33
The Varicocele: Clinical Presentation, Evaluation, and Surgical Management. (27582602)
2016
34
Comparison of the Effects of Varicocelectomy and Oral L-carnitine on Sperm Parameters in Infertile Men with Varicocele. (27190879)
2016
35
Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats. (28090212)
2016
36
Can Ultrasound Findings be a Good Predictor of Sperm Parameters in Patients With Varicocele? A Cross-Sectional Study. (27878108)
2016
37
Re: Evaluation and Management of the Adolescent Varicocele: T. F. Kolon J Urol 2015;194:1194-1201. (27154562)
2016
38
Retroperitoneal paraganglioma presenting as right-sided varicocele: case report. (26997533)
2016
39
Alterations in the proliferative/apoptotic equilibrium in semen of adolescents with varicocele. (27629121)
2016
40
Varicocele - a case for early intervention. (27508071)
2016
41
A correlation between selenium and carnitine levels with hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients. (26957259)
2016
42
Effects of varicocele on DNA methylation pattern of H19 and Snrpn gene in spermatozoa and behavioural characteristics of adult rat offspring. (27071665)
2016
43
Varicocele in a Young Man: Something We Should Be Worried About? (27481181)
2016
44
Laparoendoscopic single-site surgery varicocelectomy versus conventional laparoscopic varicocele ligation: A meta-analysis. (27688686)
2016
45
Risk of varicocele in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic disease: a population-based case-control study. (27973977)
2016
46
Increased expression of the sonic hedgehog and vascular endothelial growth factor with co-localization in varicocele veins. (26867642)
2016
47
Steroid receptors in human ejaculated sperm as molecular markers of the detrimental effects related to the pathophysiology of testicular varicocele. (27031584)
2016
48
Evaluation of enzymatic and non-enzymatic antioxidants in seminal plasma of men with genitourinary infections, varicocele and idiopathic infertility. (27027567)
2016
49
Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study. (27595632)
2016
50
Spermiogram and sperm head morphometry assessed by multivariate cluster analysis results during adolescence (12-18 years) and the effect of varicocele. (27751986)
2016

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
110.0GNRH1, SHBG
29.9CGA, GNRH1
39.9GSTM1, GSTT1
49.4CASP3, CASP9
5
Show member pathways
9.3HIF1A, NOS3
69.1NOS2, NOS3
79.1NOS2, NOS3
89.1NOS2, NOS3
99.0CASP3, CASP9, HSPA2
10
Show member pathways
9.0CASP3, CGA, NOS2, PRL
118.8HIF1A, NOS2, NOS3
12
Show member pathways
8.7HSPA2, NOS2, NOS3
138.6CASP3, CASP9, NOS3
14
Show member pathways
8.6CASP3, CASP9, NOS3
15
Show member pathways
8.5CASP3, CASP9, HSPA2, NOS2
168.5CASP3, CASP9, FASLG, HSPA2
178.3CASP9, FASLG, NOS3, PRL
18
Show member pathways
8.1CASP3, CASP9, CGA, FASLG, HSPA2
198.1CASP3, CASP9, FASLG, HIF1A, NOS2
207.8CASP3, CASP9, HIF1A, NOS2, NOS3
21
Show member pathways
7.8CASP3, CASP9, FASLG, HIF1A, NOS3
22
Show member pathways
7.6CASP3, CASP9, CGA, GNRH1, HSPA2, NOS3
23
Show member pathways
7.0AMH, CASP3, CASP9, FASLG, NOS2, NOS3

GO Terms for genes affiliated with Varicocele

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Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:190168710.6GSTM1, GSTT1
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863510.2CASP3, CASP9
3glial cell apoptotic processGO:003434910.1CASP3, CASP9
4platelet formationGO:003022010.1CASP3, CASP9
5response to cobalt ionGO:003202510.1CASP3, CASP9
6arginine catabolic processGO:00065279.8NOS2, NOS3
7nitric oxide biosynthetic processGO:00068099.8NOS2, NOS3
8nitric oxide mediated signal transductionGO:00072639.8NOS2, NOS3
9cellular response to organic cyclic compoundGO:00714079.8CASP3, CASP9, HIF1A
10positive regulation of guanylate cyclase activityGO:00312849.8NOS2, NOS3
11response to estradiolGO:00323559.8CASP3, CASP9, HIF1A
12response to X-rayGO:00101659.7CASP3, HIF1A
13cell-cell signalingGO:00072679.7AMH, CGA, FASLG, GNRH1
14activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.6CASP3, CASP9, FASLG
15positive regulation of neuron apoptotic processGO:00435259.6CASP3, CASP9, FASLG
16positive regulation of apoptotic processGO:00430659.3CASP3, CASP9, FASLG, HIF1A
17response to organic cyclic compoundGO:00140709.2AMH, CASP3, CASP9, GNRH1
18response to lipopolysaccharideGO:00324968.7CASP3, CASP9, FASLG, GNRH1, NOS2

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1death receptor bindingGO:000512310.1CASP3, FASLG
2cysteine-type endopeptidase activity involved in apoptotic processGO:009715310.0CASP3, CASP9
3arginine bindingGO:00346189.7NOS2, NOS3
4FMN bindingGO:00101819.7NOS2, NOS3
5hormone activityGO:00051799.5AMH, CGA, GNRH1, PRL
6nitric-oxide synthase activityGO:00045179.2NOS2, NOS3
7tetrahydrobiopterin bindingGO:00346179.1NOS2, NOS3

Sources for Varicocele

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet