MCID: VRC001
MIFTS: 36

Varicocele malady

Cardiovascular diseases category

Aliases & Classifications for Varicocele

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Sources:
10Disease Ontology, 12DISEASES, 65UMLS, 47Novoseek, 36MeSH, 59SNOMED-CT, 29ICD9CM, 27ICD10
See all sources

Aliases & Descriptions for Varicocele:

Name: Varicocele 10 12 65 47 36
 
Scrotal Varices 10


Classifications:



External Ids:

Disease Ontology10 DOID:12337
ICD9CM29 456.4
MeSH36 D014646
ICD1027 I86.1

Summaries for Varicocele

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MalaCards based summary: Varicocele, also known as scrotal varices, is related to azoospermia and sexual disorder. An important gene associated with Varicocele is GNRH1 (Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone)), and among its related pathways are Nongenotropic Androgen signaling and Hormone ligand-binding receptors. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia31.0GSTT1, PRL, SHBG
2sexual disorder29.9AMH, GNRH1, PRL, SHBG
3male genital organ vascular disease27.9ALB, AMH, AZF1, CASP3, CGA, CKM
4infertility11.0
5male infertility10.6
6prostatitis10.5
7oligospermia10.4
8hypoxia10.4
9male reproductive system disease10.4
10male genital disorders10.4
11hydrocele10.3
12placenta disease10.3GNRH1, PRL
13endometritis10.3GNRH1, PRL
14penoscrotal transposition10.3CGA, GNRH1
15sweat gland carcinoma10.3GNRH1, PRL
16chronic nk-cell lymphocytosis10.3GNRH1, PRL
17hypothyroidism10.3GNRH1, PRL
18morphine dependence10.3GNRH1, PRL
19fibrosarcoma10.3GNRH1, PRL
20conus medullaris neoplasm10.3GNRH1, PRL
21anovulation10.3GNRH1, PRL
22ovarian cystadenocarcinoma10.3GNRH1, PRL
23subclavian steal syndrome10.3PRL, SHBG
24childhood intracortical osteosarcoma10.2CGA, SHBG
25vein disease10.2
26ovarian mixed germ cell neoplasm10.2CGA, PRL
27creatine transporter deficiency10.2PRL, SHBG
28primary gastrointestinal melanoma10.2CASP3, PARP1
29complete atrioventricular canal10.2CGA, SHBG
30penis squamous cell carcinoma10.2PRL, SHBG
31penile disease10.2GNRH1, PRL, SHBG
32hypoglossal nerve neoplasm10.2GNRH1, PRL, SHBG
33diphyllobothriasis10.2CGA, PRL, SHBG
34diabetes insipidus10.2GNRH1, PRL, SHBG
35white piedra10.2GNRH1, PRL, SHBG
36cryptorchidism10.2
37inguinal hernia10.2
38female reproductive system disease10.2
39testicular disease10.2
40endotheliitis10.2
41hypertrichosis10.2CGA, PRL, SHBG
42pyloric antrum cancer10.2GSTM1, GSTT1
43sideroblastic anemia10.2PRL, SHBG
44frontal lobe epilepsy10.2GSTM1, GSTT1
45ectodermal dysplasia10.2GSTM1, GSTT1
46fabry disease10.1GNRH1, PRL, SHBG
47gastrin secretion abnormality10.1ALB, SHBG
48cushing's syndrome10.1ALB, SHBG
49fanconi syndrome10.1ALB, SHBG
50angular blepharoconjunctivitis10.1CGA, GNRH1, PRL, SHBG

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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Drugs & Therapeutics for Varicocele

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Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ginsengapproved, nutraceuticalPhase 48650647-08-0
2
methylene bluePhase 267
Synonyms:
Urolene Blue
aniline violet
 
methylthionine chloride
methylthioninium chloride
methylthioninium chloride Proveblue
tetrametylthionine chloride
3
Vitamin Eapproved, nutraceutical35059-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Follicle Stimulating Hormone145
5Tocotrienols352
6Tocopherols355
7TocopherolNutraceutical355
8TocotrienolNutraceutical352

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled TrialCompletedNCT01463787Phase 4
2Effects of Korean Red Ginseng on Male InfertilityCompletedNCT02202382Phase 4
3Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen AnalysisTerminatedNCT00767338Phase 3
4Dye Assisted Lymphatic Sparing Subinguinal VaricocelectomyCompletedNCT01259258Phase 2
5Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a VaricoceleCompletedNCT00044369
6The Effect of Spermatic Vein Embolization on Prostatic HypertrophyCompletedNCT00639899
7Sclerotherapy of Internal Spermatic Veins in Patients With Varicocele and Localized Prostate CancerCompletedNCT00637208
8Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than InfertilityCompletedNCT02006316
9Assessing the Rates of Major Complications in Combined Mini-incision Microscopic VaricocelectomyCompletedNCT02092311
10Single Incision Laparoscopic VaricocelectomyCompletedNCT02335385
11Varicocelectomy To Treat Pain, Predictors Of SuccessCompletedNCT01395186
12Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated AzoospermiaRecruitingNCT02306499
13The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational AnalisyRecruitingNCT02401087
14Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
15The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical StudyActive, not recruitingNCT01757548
16Oxidative Stress and Lipidomics in Male InfertilityActive, not recruitingNCT02062229
17Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenActive, not recruitingNCT00150163
18Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromEEnrolling by invitationNCT02033863
19Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of VaricocelectomyTerminatedNCT00961558
20Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?TerminatedNCT01296230

Search NIH Clinical Center for Varicocele


Cochrane evidence based reviews: Varicocele

Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

33
Testis, Testes, Prostate, Kidney, Endothelial, Smooth muscle, Pituitary

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, AMH, GNRH1, HIF1A, PRL
2MP:00053797.6ALB, AMH, CASP3, CGA, GNRH1, HIF1A
3MP:00053897.5AMH, CASP3, CGA, GNRH1, HSPA2, PARP1
4MP:00053765.6ALB, AMH, CASP3, CGA, CKM, GNRH1

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
2
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
3
Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study. (25405715)
2014
4
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele. (25179750)
2014
5
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
6
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
7
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
8
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
9
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
10
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
11
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
12
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
13
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
14
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
15
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
16
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
17
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
18
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
19
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
20
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
21
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
22
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
23
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
24
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
25
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
26
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
27
Testicular varicocele: an overview. (19506401)
2009
28
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
29
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
30
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
31
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
32
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
33
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
34
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
35
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
36
The treatment of adolescents presenting with a varicocele. (17822454)
2007
37
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
38
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
39
Antisperm antibodies and varicocele. (16466113)
2006
40
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
41
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
42
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
43
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
44
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
45
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
46
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
47
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
48
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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GO Terms for genes affiliated with Varicocele

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Biological processes related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:19016879.9GSTM1, GSTT1
2response to organic cyclic compoundGO:00140709.5AMH, CASP3, GNRH1
3gonad developmentGO:00084069.5AMH, CGA

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00043649.8GSTM1, GSTT1
2hormone activityGO:00051799.6AMH, CGA, GNRH1, PRL
3enzyme bindingGO:00198998.4GSTM1, HIF1A, HSPA2, PARP1

Sources for Varicocele

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet