MCID: VRC001
MIFTS: 51

Varicocele malady

Cardiovascular diseases category

Summaries for Varicocele

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Varicocele /ˈværɨkɵsiːl/ is an abnormal enlargement of the pampiniform venous plexus in the... more...

MalaCards: Varicocele, also known as scrotal varices, is related to infertility and male infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Glycoprotein hormones and Nongenotropic Androgen signaling. The compounds estrogen and 11 deoxycortisol have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Varicocele

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

varicocele 8 10 44 60
scrotal varices 8


External Ids:

Disease Ontology8 DOID:12337
ICD9CM27 456.4
MeSH34 D014646
ICD1025 I86.1

Related Diseases for Varicocele

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Varicocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.3SHBG, AZF1, GNRH1, USP9Y, CGA, PRL
2male infertility30.8ACR, SHBG, PRL, GNRH1, HSPA2
3azoospermia30.7ACPP, GNRH1, AMH, AZF1, USP9Y, SHBG
4prostatitis30.5ACPP
5oligospermia30.4AZF1, AMH, GNRH1, USP9Y, CGA, CGB5
6cryptorchidism30.2CGB5, CGA, SHBG, AZF1, AMH, GNRH1
7gynecomastia30.0PRL, GNRH1, CGA, CGB5, SHBG
8impotence30.0SHBG, PRL
9klinefelter's syndrome29.8AZF1, GNRH1, CGA, PRL, SHBG
10ischemia29.8BLVRB
11hypogonadism29.8CGA, SHBG, PRL, CGB5, GNRH1
12hydrocele10.3
13ankylosing spondylitis10.0
14angiokeratoma of fordyce10.0
15angiokeratoma10.0
16constipation10.0
17hepatitis10.0
18nephrotic syndrome10.0
19renal cell carcinoma10.0
20spondylitis10.0
21turner syndrome10.0GNRH1
22diabetes insipidus10.0PRL
23insulin resistance10.0SHBG
24systemic lupus erythematosus10.0PRL
25hermaphroditism10.0AMH
26obesity10.0SHBG
27hypogonadotropism10.0GNRH1, PRL
28peritonitis10.0AQP1
29mccune albright syndrome10.0GNRH1
30cushing's syndrome10.0PRL
31prostatic hypertrophy10.0GNRH1, ACPP
32thyroiditis10.0CGA
33pseudohermaphroditism10.0AMH
34seminoma10.0CGA, CGB5
35penile disease10.0GNRH1, PRL
36hypothalamic disease10.0GNRH1, PRL, CGA
37sexual disorder10.0SHBG, PRL, GNRH1
38germinoma10.0CGB5, CGA
39prolactinoma10.0GNRH1, PRL, CGA
40teratoma10.0CGB5, CGA
41ovarian hyperstimulation syndrome10.0GNRH1, CGA, CGB5
42premature ovarian failure10.0GNRH1, SHBG, PRL
43dysgerminoma10.0CGA, CGB5
44abrikosov's tumor10.0AMH, GNRH1, CGA
45ovarian cyst10.0CGB5, CGA, GNRH1
46leydig cell tumor10.0GNRH1, CGA, CGB5
47hypogonadism, hypergonadotropic10.0PRL, SHBG
48acromegaly10.0PRL, SHBG, GNRH1
49ovarian disease10.0SHBG, GNRH1, PRL, CGA
50pregnancy loss10.0CGA, CGB5, GNRH1

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Clinical Features for Varicocele

About this section

Drugs & Therapeutics for Varicocele

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Varicocele

Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Search CenterWatch for Varicocele

Genetic Tests for Varicocele

About this section

Anatomical Context for Varicocele

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Varicocele:

32
Testis, Testes, Prostate, Kidney, Endothelial, Smooth muscle, Pituitary, Colon, Spinal cord, Brain

Animal Models for Varicocele or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Varicocele:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8HSF2, AMH, GNRH1, CGA, PRL, INHBB
2MP:00053899.4AQP1, HSPA2, HSF2, AMH, GNRH1, CGA

Publications for Varicocele

About this section
Sources:
50PubMed
See all sources

Articles related to Varicocele:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
The association between varicocele and ankylosing spondylitis via color duplex sonography. (24261773)
2014
2
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
3
Ultrasound-guided transversus abdominis plane block for retroperitoneal varicocele repair. Could it be an anesthesia method? (23619829)
2013
4
Apurinic/apyrimidinic endonuclease immunoreactivity in germ cells of experimental varicocele-induced rat testes. (23706158)
2013
5
The role of varicocele treatment in the management of non-obstructive azoospermia. (23503958)
2013
6
Surgical management of nutcracker phenomenon presenting as left varicocele in adolescents: A novel approach. (24206783)
2013
7
Androgen receptor expression relationship with semen variables in infertile men with varicocele. (23201383)
2013
8
Painful varicocele in an infertile man. (23382258)
2013
9
Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele. (23926568)
2013
10
Grade 3 varicocele in fertile men: a different entity. (22341293)
2012
11
ACP(1) genetic polymorphism and spermatic parameters in men with varicocele. (23278455)
2012
12
Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. (22177844)
2012
13
Varicocele repair for low testosterone. (23026894)
2012
14
Expression of NOS isoforms in internal spermatic veins of infertile men with varicocele. (22646165)
2012
15
Varicocele among healthy young men in Turkey; prevalence and relationship with body mass index. (22397773)
2012
16
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
17
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
18
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
19
Selenium, copper and zinc in seminal plasma of men with varicocele, relationship with seminal parameters. (21240565)
2011
20
Intraabdominal laparoscopy-assisted "open" vessel ligation of testicular vessels: a potential treatment for varicocele. (21819214)
2011
21
Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. (21733620)
2011
22
Inhibin B and anti-MA1llerian hormone in spermatic vein of subfertile men with varicocele. (21285453)
2011
23
Is microsurgical technique really necessary in inguinal or sub-inguinal surgical treatment of varicocele? (21826877)
2011
24
Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats. (20797711)
2011
25
Round ligament varicocele. (21699051)
2011
26
Unexplained acute respiratory distress syndrome after varicocele surgery; report of a case. (21740396)
2011
27
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
28
Erratum: the effect of the partial obstruction site of the renal vein on testis and kidney in rats: is the traditional animal model suitable for varicocele research? (21031097)
2010
29
The effect of the partial obstruction site of the renal vein on testis and kidney in rats: is the traditional animal model suitable for varicocele research? (20733964)
2010
30
Varicocele in adolescents. (21548422)
2010
31
Intratesticular varicocele. (20354052)
2010
32
Pentoxifylline and antioxidants improve sperm quality in male patients with varicocele. (18990381)
2009
33
Male factor infertility: innovations in varicocele surgery. (19727143)
2009
34
The effect of vascular endothelial growth factor on spermatogenesis and apoptosis in experimentally varicocele-induced adolescent rats. (18701100)
2009
35
Seminal plasma total antioxidant capacity and semen parameters in patients with varicocele. (19549438)
2009
36
Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats. (19145435)
2009
37
Evolving management of adolescent varicocele. (18631904)
2008
38
Varicocele and testicular volume: the need for common terminology. (18787514)
2008
39
Increased testicular 8-hydroxy-2'-deoxyguanosine in patients with varicocele. (17559562)
2007
40
Immunolocalization of glial cell-derived neurotrophic factor (GDNF) and its receptor GFR-alpha1 in varicocele-induced rat testis. (17240430)
2007
41
Male infertility and varicocele: myths and reality. (19582201)
2007
42
The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. (17898401)
2007
43
Bcl-2 overexpression in the internal spermatic vein of patients with varicocele. (17475608)
2007
44
Is bilateral varicocele more detrimental to male fertility than unilateral varicocele? (17519909)
2007
45
Antisperm antibodies and varicocele. (16466113)
2006
46
Surgical ligation of scrotal varicocele for male factor infertility is a valid option of treatment. (16967788)
2006
47
The adolescent varicocele. II: the incidence of hydrocele and delayed recurrent varicocele after varicocelectomy in a long-term follow-up. (11298041)
2001
48
The naloxone test in patients with varicocele]. (9695347)
1998
49
The effect of smoking and varicocele on human sperm acrosin activity and acrosome reaction. (8822441)
1995
50
Nephrosis with varicocele: probable renal vein thrombosis. (4029240)
1985

Genetic Variations for Varicocele

About this section

Expression for genes affiliated with Varicocele

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
See all sources

Pathways related to Varicocele according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GNRH1, CGA
210.3SHBG, GNRH1
3
Hide members
10.3HMOX2, BLVRB
4
Hide members
10.3HMOX2, BLVRB
510.3BLVRB, ACPP

Compounds for genes affiliated with Varicocele

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Varicocele according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7HSF2, ACPP
211 deoxycortisol4410.6SHBG, CGA, PRL
3estradiol benzoate4410.6CGB5, GNRH1, PRL, CGA
4leuprolide44 59 28 1113.6GNRH1, PRL, CGB5, CGA
5goserelin44 28 1112.6ACPP, GNRH1, SHBG, CGA
6metoclopramide44 1111.6GNRH1, PRL, CGA
7cyproteroneacetate4410.6GNRH1, PRL, SHBG, ACPP
8bromocriptine28 44 1112.6GNRH1, CGA, SHBG, PRL
9flutamide44 59 1112.6SHBG, GNRH1, CGA, ACPP, PRL
1017-hydroxypregnenolone4410.6SHBG, CGB5, CGA, ACPP
11toremifene44 1111.5SHBG, PRL, GNRH1
12leuprolide acetate4410.5GNRH1, CGA, CGB5, PRL, SHBG
13cetrorelix44 28 1112.5CGB5, CGA, GNRH1
14clomiphene citrate4410.5PRL, CGB5, CGA, GNRH1, SHBG
15buserelin44 28 1112.5ACPP, CGB5, PRL, CGA, GNRH1
16dopamine44 28 11 2413.5BLVRB, HMOX2, GNRH1, SHBG
17naloxone44 49 28 1113.5GNRH1, CGB5, PRL, CGA
18danazol44 11 2412.5GNRH1, SHBG, PRL
19altrenogest4410.5CGA, GNRH1
20percoll4410.5ACR, CGB5, CGA, LDHC
21cabergoline28 44 1112.5PRL, GNRH1, CGA
22progestin4410.5CGB5, GNRH1, PRL, SHBG, CGA
23diethylstilbestrol44 28 1112.5GNRH1, CGB5, SHBG, ACPP, CGA
2417-hydroxyprogesterone44 2411.5SHBG, GNRH1, ACPP, CGA, CGB5, PRL
25dehydroepiandrosterone sulfate4410.5CGB5, PRL, CGA, GNRH1, ACPP, SHBG
26mifepristone44 59 28 1113.5AMH, GNRH1, CGA, CGB5, PRL, SHBG
27dhea4410.5ACPP, CGB5, PRL, SHBG
28androstenedione44 2411.5CGB5, GNRH1, PRL, CGA, ACPP, SHBG
29gnrh4410.4BLVRB, INHBB, ACPP, CGA, GNRH1, SHBG
3011-ketotestosterone4410.4CGA, CGB5
31metrodin4410.4CGA, GNRH1
32estrone44 28 11 2413.4GNRH1, CGB5, PRL, SHBG
33dihydrotestosterone44 28 11 2413.4CGA, ACPP, CGB5, GNRH1, PRL, SHBG
34sodium nitroprusside4410.4AQP1, GNRH1, CGA, BLVRB, CGB5
35acth4410.4PRL, ACPP, SHBG, CGB5, GNRH1
36epinephrine44 11 2412.4GNRH1, CGB5, PRL, SHBG, CGA
37tamoxifen44 49 28 1113.4SHBG, PRL, CGA, CGB5, AMH, GNRH1
38ribonucleic acid4410.4GNRH1, CGA, CGB5, PRL, HMOX2
39deslorelin4410.4GNRH1, CGA
40estradiol44 11 2412.3ACPP, BLVRB, SHBG, PRL, CGB5, CGA
41pergonal4410.3CGA, GNRH1
42lactate4410.2GNRH1, LDHC, ACR, ACPP, CGA, GLA
43creatinine4410.2AQP1, LDHC, ACPP, GLA, SHBG, CGB5
44steroid4410.2SHBG, GNRH1, CGB5, CGA, BLVRB, ACPP
45progesterone44 59 28 11 2414.2BLVRB, HMOX2, ACPP, CGB5, SHBG, PRL
46adenylate4410.2BLVRB, CGA, CGB5, SHBG, NT5E, GNRH1
47testosterone44 59 11 2413.2CGB5, LDHC, ACPP, CGA, BLVRB, SHBG
48norepinephrine44 11 2412.1GNRH1, CGA, CGB5, SHBG, PRL
49arginine4410.0SHBG, ACR, ACPP, HMOX2, GLA, BLVRB
50(+-)-pgf2-alpha449.9GNRH1, CGA, CGB5

GO Terms for genes affiliated with Varicocele

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8ACR, ACPP, INHBB, GLA, SHBG, PRL

Biological processes related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.3HMOX2, BLVRB
2heme catabolic processGO:04216710.2HMOX2, BLVRB
3ovulation cycleGO:04269810.0PRL, GNRH1

Molecular functions related to Varicocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.1SHBG, GLA, INHBB, ACPP, HSF2
2hormone activityGO:0051799.8INHBB, PRL, CGA, GNRH1, AMH

Products for genes affiliated with Varicocele

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Varicocele

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet