MCID: VRC001
MIFTS: 42

Varicocele malady

Cardiovascular diseases category

Aliases & Classifications for Varicocele

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
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Varicocele, Aliases & Descriptions:

Name: Varicocele 9 11 43 60
 
Scrotal Varices 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:12337
ICD9CM27 456.4
MeSH33 D014646
ICD1025 I86.1

Summaries for Varicocele

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Wikipedia:63 A varicocele /?v more...

MalaCards based summary: Varicocele, also known as scrotal varices, is related to male infertility and infertility. An important gene associated with Varicocele is AZF1 (azoospermia factor 1), and among its related pathways are Hormone ligand-binding receptors and Glucocorticoid receptor regulatory network. The compounds altrenogest and deslorelin have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are integument and endocrine/exocrine gland.

Related Diseases for Varicocele

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Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1male infertility30.8PRL, SHBG, GNRH1
2infertility30.6AZF1, GNRH1, SHBG, AMH, PRL, CGA
3impotence30.3SHBG, PRL
4oligospermia30.1AZF1, GNRH1, AMH, PRL, CGA
5gynecomastia29.9GNRH1, SHBG, PRL, CGA
6cryptorchidism29.8CGA, AMH, SHBG, GNRH1, AZF1
7azoospermia29.7AZF1, GNRH1, SHBG, AMH, PRL, ACPP
8hypogonadism29.6GNRH1, SHBG, PRL, CGA
9klinefelter's syndrome29.4AZF1, GNRH1, SHBG, PRL, CGA
10mccune-albright syndrome, somatic, mosaic10.5GNRH1
11prostatitis10.4
12hermaphroditism10.4AMH
13hypoxia10.4
14hydrocele10.3
15penis agenesis10.3CGA, GNRH1
16ovarian cyst10.3GNRH1, CGA
17ovarian hyperstimulation syndrome10.3GNRH1, CGA
18prostatic hypertrophy10.2GNRH1, ACPP
19penile disease10.2PRL, GNRH1
20hypogonadotropism10.2PRL, GNRH1
21varicose veins10.2
22kallmann syndrome10.2CGA, GNRH1
23diabetes insipidus, neurohypophyseal10.2GNRH1, PRL
24pituitary apoplexy10.2PRL, GNRH1
25pituitary gland disease10.2GNRH1, PRL
26leydig cell tumor10.2CGA, GNRH1
27premature ovarian failure10.2GNRH1, AMH
28endotheliitis10.2
29androgen insensitivity10.1SHBG, CGA
30turner syndrome10.1CGA, SHBG
31hypothyroidism10.1CGA, SHBG
32hyperinsulinism10.1GNRH1, SHBG
33uterine fibroid10.1SHBG, GNRH1
34cushing's syndrome10.1GNRH1, PRL
35renal cell carcinoma10.1
36hepatitis10.1
37angiokeratoma10.1
38constipation10.1
39nephrotic syndrome10.1
40spondylitis10.1
41hypothalamic disease10.1GNRH1, PRL, CGA
42abrikosov's tumor10.1GNRH1, AMH, CGA
43pituitary tumors10.1PRL, GNRH1
44hypoglycemia10.1PRL, GNRH1
45prolactinoma10.1GNRH1, PRL, CGA
46pituitary adenoma10.0CGA, PRL, GNRH1
47non-suppurative otitis media10.0ACPP, SHBG
48testicular cancer10.0AZF1, SHBG, CGA
49anorexia nervosa10.0PRL, SHBG
50sexual disorder10.0GNRH1, SHBG, PRL

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to varicocele

Symptoms for Varicocele

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Drugs & Therapeutics for Varicocele

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Drug clinical trials:

Search ClinicalTrials for Varicocele

Search NIH Clinical Center for Varicocele

Genetic Tests for Varicocele

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Anatomical Context for Varicocele

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MalaCards organs/tissues related to Varicocele:

31
Testis, Testes, Prostate, Kidney, Smooth muscle, Endothelial, Pituitary, Brain, Spinal cord, Colon

Animal Models for Varicocele or affiliated genes

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MGI Mouse Phenotypes related to Varicocele:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0INHBB, GNRH1, PRL, ACPP
2MP:00053797.8CGA, PRL, AMH, GNRH1, INHBB
3MP:00053767.8CGA, PRL, AMH, GNRH1, INHBB
4MP:00053897.7INHBB, GNRH1, AMH, PRL, CGA

Publications for Varicocele

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Articles related to Varicocele:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Human sperm molecular anatomy: the enzyme 5I+-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infertility. (25850410)
2015
2
DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. (25747432)
2015
3
Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study. (25405715)
2014
4
Increases in interleukin-6 and interferon-gamma levels is progressive in immature rats with varicocele. (25179750)
2014
5
Relationship of spermatozoal DNA fragmentation with semen quality in varicocele-positive men. (25346327)
2014
6
Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. (23171426)
2013
7
The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. (24078505)
2013
8
Infrared digital thermography of scrotum in early selection of progressive varicocele. (23891041)
2013
9
Study of sperm protein profile in men with and without varicocele using two-dimensional gel electrophoresis. (23374786)
2013
10
Pubertal screening and treatment for varicocele do not improve chance of paternity as adult. (23261480)
2013
11
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
12
Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. (21664780)
2012
13
Glutathione S-transferase M1 and T1 polymorphisms in Turkish patients with varicocele. (21488930)
2012
14
Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. (22417329)
2012
15
Incidence and clinical significance of arterial injury in varicocele repair. (20950303)
2011
16
Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. (21924715)
2011
17
Effects of artery-ligating and artery-preserving varicocelectomy on ipsilateral epididymis of varicocele-induced rats. (21269666)
2011
18
The validity of testicular catch-up growth and serum FSH levels in the long-term postoperative assessment of laparoscopic varicocele correction in adolescents. (21346830)
2011
19
Effect of varicocele grade and age on seminal parameters. (20424431)
2010
20
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
21
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
22
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. (20019389)
2010
23
Effects of bioflavonoids in the management of subclinical varicocele. (20162420)
2010
24
Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele. (19942233)
2010
25
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
26
Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall. (19030866)
2009
27
Re: Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. K. A. Kozakowski, C. K. Gjertson, G. J. Decastro, S. Poon, A. Gasalberti and K. I. Glassberg. J Urol 2009; 181: 2717-2723. (19846126)
2009
28
Testicular varicocele: an overview. (19506401)
2009
29
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. (19674254)
2009
30
Re: Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. H. Sakamoto and Y. Ogawa. J Urol 2008; 180: 1427-1431. (19540531)
2009
31
Comparison of prevalence of varicocele in first-degree relatives of patients with varicocele and male kidney donors. (18279919)
2008
32
Long-term effect of varicocele repair on intratesticular arterial resistance index. (18088054)
2008
33
Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. (18932107)
2008
34
A new experimental inbred Wistar rat varicocele model: anatomy of the left spermatic vein and the effect on histology. (18211296)
2008
35
Predictors of success in surgical ligation of painful varicocele. (17627165)
2007
36
Globozoospermia: is there a role for varicocele repair? (17460092)
2007
37
The treatment of adolescents presenting with a varicocele. (17822454)
2007
38
alpha-1,4-Glucosidase activity in infertile oligoasthenozoospermic men with and without varicocele. (17212807)
2007
39
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age. (17124484)
2006
40
Antisperm antibodies and varicocele. (16466113)
2006
41
Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. (16598029)
2006
42
Sperm nuclear DNA fragmentation in adolescents with varicocele. (16500329)
2006
43
Somatic angiotensin converting enzyme in varicocele. (16728350)
2006
44
Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index. (16904459)
2006
45
Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. (16400086)
2006
46
Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. (11789975)
2001
47
Varicocele as a progressive lesion: positive effect of varicocele repair. (11212075)
2001
48
Controversies in the evolution of paediatric-adolescent varicocele: clinical, biochemical and histological studies. (11124861)
2000
49
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. (1305061)
1992
50
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. (1977719)
1990

Variations for Varicocele

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Expression for genes affiliated with Varicocele

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Search GEO for disease gene expression data for Varicocele.

Pathways for genes affiliated with Varicocele

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Compounds for genes affiliated with Varicocele

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Compounds related to Varicocele according to GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1altrenogest4310.0GNRH1, CGA
2deslorelin4310.0GNRH1, CGA
3pergonal4310.0GNRH1, CGA
4metrodin4310.0GNRH1, CGA
5antarelix43 2810.9GNRH1, CGA
6ganirelix43 2810.9CGA, GNRH1
7d-trp6-lhrh439.8GNRH1, CGA
8epitestosterone439.7SHBG, CGA
9estradiol benzoate439.6CGA, PRL, GNRH1
10leuprolide43 59 28 1212.6GNRH1, PRL, CGA
11metoclopramide43 49 1211.5GNRH1, PRL, CGA
12cabergoline43 28 1211.5GNRH1, PRL, CGA
13naloxone43 28 49 1212.4CGA, PRL, GNRH1
14chlormadinone acetate439.4SHBG, ACPP
1517-hydroxypregnenolone439.4SHBG, ACPP, CGA
16toremifene43 1210.3PRL, SHBG, GNRH1
17opiate439.3GNRH1, PRL, CGA
18danazol43 24 1211.3GNRH1, SHBG, PRL
1911 deoxycortisol439.3CGA, PRL, SHBG
20metformin43 49 1211.3GNRH1, SHBG, CGA
21buserelin43 28 1211.2GNRH1, PRL, ACPP, CGA
22goserelin43 28 1211.1GNRH1, SHBG, ACPP, CGA
23diethylstilbestrol43 28 1211.0GNRH1, SHBG, ACPP, CGA
24dhea439.0ACPP, PRL, SHBG
25leuprolide acetate439.0GNRH1, SHBG, PRL, CGA
26clomiphene citrate439.0GNRH1, SHBG, PRL, CGA
27bromocriptine43 28 1211.0GNRH1, SHBG, PRL, CGA
28progestin438.9GNRH1, SHBG, PRL, CGA
29cyproteroneacetate438.9GNRH1, SHBG, PRL, ACPP
30thyroxine43 249.9GNRH1, SHBG, PRL, CGA
31acth438.8GNRH1, SHBG, PRL, ACPP
32epinephrine43 24 1210.8GNRH1, SHBG, PRL, CGA
33triiodothyronine438.8CGA, PRL, SHBG
34norepinephrine43 24 1210.8CGA, PRL, SHBG, GNRH1
35dopamine43 28 24 1211.5CGA, PRL, SHBG, GNRH1
3617-hydroxyprogesterone43 249.5CGA, ACPP, PRL, SHBG, GNRH1
37flutamide43 59 1210.5GNRH1, SHBG, PRL, ACPP, CGA
38dehydroepiandrosterone sulfate438.5GNRH1, SHBG, PRL, ACPP, CGA
39androstenedione43 249.5GNRH1, SHBG, PRL, ACPP, CGA
40dihydrotestosterone43 28 24 1211.5GNRH1, SHBG, PRL, ACPP, CGA
41mifepristone43 28 59 1211.5GNRH1, SHBG, AMH, PRL, CGA
42tamoxifen43 49 28 1211.4GNRH1, SHBG, AMH, PRL, CGA
43steroid438.4GNRH1, SHBG, PRL, ACPP, CGA
44arginine438.4GNRH1, SHBG, PRL, ACPP, CGA
45lactate438.3GNRH1, SHBG, ACPP, CGA
46estradiol43 24 1210.0GNRH1, SHBG, AMH, PRL, ACPP, CGA
47progesterone43 28 59 24 1212.0GNRH1, SHBG, AMH, PRL, ACPP, CGA
48testosterone43 59 24 1211.0GNRH1, SHBG, AMH, PRL, ACPP, CGA
49estrogen437.9GNRH1, SHBG, AMH, PRL, ACPP, CGA
50gnrh437.7INHBB, GNRH1, SHBG, PRL, ACPP, CGA

GO Terms for genes affiliated with Varicocele

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Cellular components related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2CGA, PRL, AMH, SHBG, GNRH1, INHBB

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1female pregnancyGO:00075659.6PRL, GNRH1
2cell-cell signalingGO:00072678.9CGA, AMH, GNRH1

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051797.8CGA, PRL, AMH, GNRH1, INHBB

Products for genes affiliated with Varicocele

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Sources for Varicocele

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet