MCID: VRC005
MIFTS: 37

Varicose Veins malady

Cardiovascular diseases category

Summaries for Varicose Veins

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Varicose veins are swollen, twisted veins that you can see just under the skin. they usually occur in the legs, but also can form in other parts of the body. hemorrhoids are a type of varicose vein. your veins have one-way valves that help keep blood flowing toward your heart. if the valves are weak or damaged, blood can back up and pool in your veins. this causes the veins to swell, which can lead to varicose veins. varicose veins are very common. you are more at risk if you are older, a female, obese, don't exercise or have a family history. they can also be more common in pregnancy. doctors often diagnose varicose veins from a physical exam. sometimes you may need additional tests. exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. wearing loose clothing and avoiding long periods of standing can also help. if varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. nih: national heart, lung, and blood institute

MalaCards: Varicose Veins is related to hypertension and thrombophilia. An important gene associated with Varicose Veins is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Angiogenesis. The compounds (4-aminophenyl)mercuric acetate and glutamate have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are integument and liver/biliary system.

Wikipedia:63 Varicose veins are veins that have become enlarged and tortuous (twisted). The term commonly refers to... more...

Aliases & Classifications for Varicose Veins

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10DISEASES, 33MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

varicose veins 10 33


Related Diseases for Varicose Veins

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to varicose veins

Clinical Features for Varicose Veins

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Drugs & Therapeutics for Varicose Veins

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Varicose Veins

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Anatomical Context for Varicose Veins

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32MalaCards
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MalaCards organs/tissues related to Varicose Veins:

32
Heart, Skin, Lung, Testes

Animal Models for Varicose Veins or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Varicose Veins:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2TIMP3, EDNRB, EDN3, PROS1
2MP:000537010.0TIMP3, FOXC2, PROS1, PROC, EPAS1, THBD
3MP:00053699.9TIMP3, FOXC2, MGP, EDNRB, PROS1, PROC
4MP:00053889.8ELN, TIMP3, FOXC2, MGP, EDNRB, PROC
5MP:00028739.8MRC2, FOXC2, PROS1, RAB3D, THBD, NOTCH3
6MP:00053809.8FOXC2, EDNRB, EDN3, PROS1, EPAS1, THBD
7MP:00053879.7TIMP2, TIMP3, MRC2, FOXC2, EDNRB, PROC
8MP:00053679.7TIMP3, FOXC2, MGP, EDNRB, THBD, NOTCH3
9MP:00036319.7TIMP2, FOXC2, EDNRB, EDN3, PROS1, PROC
10MP:00107689.6EDN3, EDNRB, MGP, FOXC2, TIMP3, PROS1
11MP:00053769.5C6, EDNRB, FOXC2, TIMP3, TIMP2, PROS1

Publications for Varicose Veins

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Genetic Variations for Varicose Veins

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Expression for genes affiliated with Varicose Veins

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Varicose Veins

Search GEO for disease gene expression data for Varicose Veins.

Pathways for genes affiliated with Varicose Veins

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Sources:
53Reactome, 49PharmGKB, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 52R&D Systems, 29KEGG
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Pathways related to Varicose Veins according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MGP, PROS1, PROC
210.2NOTCH3, TIMP3, TIMP2
3
Hide members
10.2MMP3, TIMP3, TIMP2
4
Cell adhesion Cell-matrix glycoconjugates
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10.2TIMP2, MMP3, ELN
510.2THBD, PROC, PROS1
6
Cell adhesion ECM remodeling
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10.1ELN, MMP3, TIMP3, TIMP2
7
Hide members
10.1THBD, PROC, PROS1, F13B
8
Hide members
10.1THBD, PROC, PROS1, F13B
9
Hide members
10.0C6, F13B, PROS1, PROC, THBD
10
Hide members
10.0TIMP2, F13B, PROS1, PROC, MMP3, THBD

Compounds for genes affiliated with Varicose Veins

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Varicose Veins according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4410.8MMP3
2glutamate4410.7MGP, THBD
3Sodium Tetradecyl Sulfate1110.7PROS1, PROC
4bq6104410.7EDN3, EDNRB
5bq 302044 2811.7EDNRB, EDN3
6pd 1428934410.7EDN3, EDNRB
7sarafotoxin4410.7EDN3, EDNRB
8fr13931744 2811.7EDNRB, EDN3
9matrigel4410.6MMP3
10tezosentan4410.6EDN3, EDNRB
11irl 162044 2811.6EDNRB, EDN3
121,10-phenanthroline44 211.6TIMP2, TIMP3, MMP3
13bq78844 2811.6EDNRB, EDN3
14batimastat44 59 1112.6MMP3, TIMP3, TIMP2
15gamma-carboxyglutamic acid4410.6MGP, PROS1, PROC, THBD
16dexamethasone44 49 28 1113.6EDN3, PROS1, EDNRB, TIMP3
17bq12344 2811.5EDNRB, EDN3
18chondroitin sulfate44 2411.5ELN, THBD, TIMP3, MMP3
19losartan44 49 28 1113.5THBD, ELN, TIMP2, EDNRB
20warfarin44 49 11 2413.5THBD, PROC, MGP
21agarose4410.5TIMP2, EDNRB, TIMP3, THBD
22hyaluronic acid44 2411.5TIMP2, MMP3, ELN, THBD
23heparin44 28 11 2413.5PROS1, TIMP3, TIMP2, MMP3, ELN
24glycosaminoglycan4410.5TIMP3, MMP3, TIMP2, ELN, THBD
25prostacyclin4410.5THBD, EDNRB, EDN3, PROS1
26indomethacin44 59 28 1113.4MMP3, EDNRB, ELN, PROS1, EDN3
27vitamin d4410.4MGP, THBD, PROS1, MMP3, ELN
28dmso4410.4MMP3, THBD, ELN, EDNRB
29estrogen4410.4ELN, MGP
30dbc-amp4410.4TIMP3, EDN3, THBD
31paraffin4410.4TIMP2, ELN, THBD, MMP3, TIMP3
32lysine4410.4MGP, EDNRB, EDN3, ELN, TIMP2
33latanoprost44 1111.4TIMP2, MMP3
34ribonucleic acid4410.4EDN3, TIMP2, MMP3, TIMP3
35tyrosine4410.3THBD, EPAS1, EDN3, PROS1, EDNRB
36glucose4410.3EDN3, TIMP2, TIMP3, FOXC2, EDNRB, PROS1
37bosentan44 1111.3EDNRB, EDN3
38serine4410.3MMP3, TIMP2, MGP, EDNRB, EDN3, PROS1
39ascorbic acid44 2411.3MMP3, THBD, ELN, TIMP2
40creatinine4410.3ELN, MMP3, PROS1, THBD, TIMP2
41arginine4410.3EDNRB, EDN3, PROS1, ELN, NOTCH3, THBD
42retinoic acid44 2411.3ELN, TIMP2, TIMP3, MGP, EDNRB, MMP3
43cysteine4410.3TIMP2, EDNRB, THBD, NOTCH3, ELN, TIMP3
44alanine4410.2MMP3, ELN, EDNRB, THBD, EDN3, TIMP2
45pravastatin44 49 28 11 2414.2THBD, TIMP2, MMP3
46vegf4410.1EDN3, EPAS1, MMP3, THBD, ELN, TIMP3
47oxygen44 2411.1TIMP2, TIMP3, FAM215A, EDNRB, EPAS1, MMP3
48methionine4410.0THBD, MMP3, TIMP3, EDN3
49calcium44 49 11 2412.9TIMP3, TIMP2, MGP, MRC2, ELN, NOTCH3
50progesterone44 59 28 11 2413.7THBD, TIMP2, TIMP3, EDN3, MMP3

GO Terms for genes affiliated with Varicose Veins

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16Gene Ontology
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Cellular components related to Varicose Veins according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1ELN, MMP3, DPT, MGP
2extracellular regionGO:0055769.4ELN, TIMP2, EDN3, C6, F13B, PROS1

Biological processes related to Varicose Veins according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.4EDN3, EDNRB
2blood vessel remodelingGO:00197410.4ELN, EPAS1, FOXC2
3peptidyl-glutamic acid carboxylationGO:01718710.4PROC, PROS1
4cellular response to organic substanceGO:07131010.3TIMP3, TIMP2
5negative regulation of blood coagulationGO:03019510.3PROC, THBD
6leukocyte migrationGO:05090010.1THBD, PROC, PROS1
7vasoconstrictionGO:04231010.0EDN3, EDNRB

Molecular functions related to Varicose Veins according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00819110.3TIMP3, TIMP2
2calcium ion bindingGO:0055099.7NOTCH3, THBD, MMP3, PROC, PROS1, MGP

Products for genes affiliated with Varicose Veins

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Varicose Veins

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet