MCID: VRC005
MIFTS: 42

Varicose Veins malady

Cardiovascular diseases category

Summaries for Varicose Veins

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Varicose veins are swollen, twisted veins that you can see just under the skin. they usually occur in the legs, but also can form in other parts of the body. hemorrhoids are a type of varicose vein. your veins have one-way valves that help keep blood flowing toward your heart. if the valves are weak or damaged, blood can back up and pool in your veins. this causes the veins to swell, which can lead to varicose veins. varicose veins are very common. you are more at risk if you are older, a female, obese, don't exercise or have a family history. they can also be more common in pregnancy. doctors often diagnose varicose veins from a physical exam. sometimes you may need additional tests. exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. wearing loose clothing and avoiding long periods of standing can also help. if varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. nih: national heart, lung, and blood institute

MalaCards: Varicose Veins is related to aneurysm and liver cirrhosis. An important gene associated with Varicose Veins is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)), and among its related pathways are Endochondral Ossification and Angiogenesis. The compounds 1,10-phenanthroline and batimastat have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and skeletal muscle, and related mouse phenotypes are pigmentation and renal/urinary system.

Wikipedia:66 Varicose veins are veins that have become enlarged and tortuous (twisted). The term commonly refers to... more...

Aliases & Classifications for Varicose Veins

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11DISEASES, 35MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

varicose veins 11 35


Related Diseases for Varicose Veins

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to varicose veins

Symptoms for Varicose Veins

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Drugs & Therapeutics for Varicose Veins

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Varicose Veins

Drug clinical trials:

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Search NIH Clinical Center for Varicose Veins

Search CenterWatch for Varicose Veins

Genetic Tests for Varicose Veins

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Anatomical Context for Varicose Veins

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34MalaCards
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MalaCards organs/tissues related to Varicose Veins:

34
Skin, Heart, Skeletal muscle, Testes, Lung, Smooth muscle, Endothelial, Liver, Brain, Lymph node, Eye

Animal Models for Varicose Veins or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Varicose Veins:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9FOXC2, TIMP3, EDN3
2MP:00053678.3MGP, TIMP3, FOXC2, NOTCH3
3MP:00053888.2MGP, TIMP3, FOXC2, NOTCH3
4MP:00053698.0MGP, TIMP3, FOXC2, NOTCH3
5MP:00053767.8NOTCH3, FOXC2, TIMP2, TIMP3, MGP
6MP:00107687.4LTBP2, NOTCH3, FOXC2, TIMP3, MGP, EDN3

Publications for Varicose Veins

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Sources:
53PubMed
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Articles related to Varicose Veins:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Analysing exhaled breath during endovenous laser ablation of varicose veins using an electronic nose and gas chromatography-mass spectrometry. (24113434)
2013
2
Varicose veins: diagnosis and management. (24288936)
2013
3
A novel biomimetic analysis system for quantitative characterisation of sclerosing foams used for the treatment of varicose veins. (23512153)
2013
4
The relative impact on leg symptoms of fears of getting varicose veins and of great saphenous vein reflux. (22539539)
2013
5
Rheological properties of young and aged erythrocytes in chronic venous disease patients with varicose veins. (23594503)
2013
6
Medical liability insurance claims after treatment of varicose veins. (23508005)
2013
7
Medium-term results of ultrasonography-guided, catheter-assisted foam sclerotherapy of the long saphenous vein for treatment of varicose veins. (22337181)
2012
8
Results of endovenous ClosureFast treatment for varicose veins in an outpatient setting. (21572060)
2012
9
What is the medical rationale for the treatment of varicose veins? (22312064)
2012
10
Anatomical variations of the saphenofemoral junction in patients with varicose veins. (23109028)
2012
11
Neurological complications of sclerotherapy for varicose veins. (21840152)
2012
12
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. (23997567)
2012
13
Foam sclerotherapy for spouting haemorrhage in patients with varicose veins. (21420881)
2011
14
Correlation between the hemodynamic gain obtained after operation of primary varicose veins and chronic venous disease classification. (22030826)
2011
15
Three-dimensional CT Venography: A Diagnostic Modality for the Preoperative Assessment of Patients with Varicose Veins. (23555458)
2011
16
Radiofrequency induced thermotherapy (RFITT) of varicose veins compared to endovenous laser treatment (EVLT): a non-randomized prospective study concentrating on occlusion rates, side-effects and clinical outcome. (21914582)
2011
17
Visual loss following sclerotherapy for varicose veins. (22715265)
2011
18
Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. (21498026)
2011
19
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
20
Commentary: Outcomes of ultrasound-guided foam sclerotherapy for varicose veins of the lower extremities: single center experience. (21605243)
2011
21
Validation of the chronic venous insufficiency quality of life questionnaire in Dutch patients treated for varicose veins. (21531589)
2011
22
What is involved in having varicose veins removed--and is there any danger if I don't have them removed? (20669357)
2010
23
Randomized clinical trial of radiofrequency ablation or conventional high ligation and stripping for great saphenous varicose veins. (20035541)
2010
24
Percutaneus treatment of varicose veins with bipolar radiofrequency ablation. (20554143)
2010
25
Varicose veins. (20191746)
2010
26
Chronic venous insufficiency: current management of varicose vein disease. (20336886)
2010
27
Endovenous laser treatment for uncomplicated varicose veins. (19307441)
2009
28
Current evaluation and treatment of lower extremity varicose veins. (19486710)
2009
29
Pathogenesis of primary varicose veins. (19847861)
2009
30
Outcome of endovenous laser therapy for saphenous reflux and varicose veins: medium-term results assessed by ultrasound surveillance. (18993093)
2009
31
Microembolism during foam sclerotherapy of varicose veins. (18385510)
2008
32
Three-Dimensional CT venography of varicose veins of the lower extremity: image quality and comparison with doppler sonography. (18806163)
2008
33
Varicose veins. (18751493)
2008
34
Relationship between parameters of air plethysmography and types of superficial venous reflux in patients with primary varicose veins. (18974700)
2008
35
Varicose veins in ambulatory surgery : patients' perception. (17515266)
2007
36
Initial experience in endovenous laser ablation (EVLA) of varicose veins due to small saphenous vein reflux. (17227716)
2007
37
Varicose veins: Hippocrates to Jerry Moore. (17973674)
2007
38
Foam sclerotherapy for the treatment of varicose veins. (17976326)
2007
39
Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. (17264019)
2007
40
Randomized trial comparing endovenous laser ablation of the great saphenous vein with high ligation and stripping in patients with varicose veins: short-term results. (17600655)
2007
41
A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins. (16802211)
2006
42
How should a candidate assess varicose veins in the MRCS clinical examination? A vascular viewpoint. (16720005)
2006
43
Endovenous laser ablation of saphenous vein is an effective treatment modality for lower extremity varicose veins. (16913308)
2006
44
Endovenous laser therapy and radiofrequency ablation of saphenous varicose veins. (16434940)
2006
45
Ultrasonographic analysis in vitro of parietal thickness of lower limb varicose veins. (16896555)
2006
46
Clinical results of radiofrequency endovenous obliteration for varicose veins. (15622464)
2005
47
Haemodynamic strategy for treatment of diastolic anterograde giacomini varicose veins. (15933990)
2005
48
Endovenous laser ablation of the saphenous vein for treatment of venous insufficiency and varicose veins: early results from a large single-center experience. (15056020)
2004
49
Characterization of endothelin receptors in human varicose veins. (9240323)
1997
50
Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins. (1783414)
1991

Variations for Varicose Veins

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Expression for genes affiliated with Varicose Veins

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Varicose Veins

Search GEO for disease gene expression data for Varicose Veins.

Pathways for genes affiliated with Varicose Veins

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 61Thomson Reuters, 13EMD Millipore, 54QIAGEN, 56Reactome
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Pathways related to Varicose Veins according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2MGP, TIMP3
2
Show member pathways
Angiogenesis39
9.1TIMP2, TIMP3
3
Show member pathways
9.1TIMP2, TIMP3
4
Show member pathways
9.1TIMP3, TIMP2
5
Show member pathways
8.6TIMP3, TIMP2, LTBP2
6
Show member pathways
8.6LTBP2, TIMP2, TIMP3
7
Show member pathways
8.6TIMP3, TIMP2, LTBP2
8
Show member pathways
8.6TIMP3, TIMP2, LTBP2
9
Show member pathways
8.6LTBP2, TIMP2, TIMP3
10
Show member pathways
8.6TIMP3, TIMP2, LTBP2
11
Show member pathways
8.6LTBP2, TIMP2, TIMP3
12
Show member pathways
8.6LTBP2, TIMP2, TIMP3
13
Show member pathways
8.6LTBP2, TIMP2, TIMP3
14
Show member pathways
8.6TIMP3, TIMP2, LTBP2
158.5NOTCH3, TIMP2, TIMP3
16
Show member pathways
8.0TIMP3, TIMP2, NOTCH3, LTBP2
17
Show member pathways
8.0LTBP2, NOTCH3, TIMP2, TIMP3

Compounds for genes affiliated with Varicose Veins

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Sources:
46Novoseek, 3BitterDB, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Varicose Veins according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
11,10-phenanthroline46 310.3TIMP2, TIMP3
2batimastat46 62 1211.2TIMP3, TIMP2
3dbc-amp469.2TIMP3, EDN3
4lysine469.2TIMP2, MGP, EDN3
5ribonucleic acid468.9EDN3, TIMP3, TIMP2
6glycosaminoglycan468.8TIMP2, TIMP3
7oligonucleotide468.7TIMP2, TIMP3, EDN3
8progesterone46 30 62 25 1212.6EDN3, TIMP3, TIMP2
9glucose468.5FOXC2, TIMP2, TIMP3, EDN3
10calcium46 52 25 1210.3LTBP2, NOTCH3, TIMP2, TIMP3, MGP, EDN3

GO Terms for genes affiliated with Varicose Veins

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17Gene Ontology
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Cellular components related to Varicose Veins according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.1TIMP2, TIMP3
2extracellular matrixGO:0310128.6LTBP2, TIMP3, MGP
3extracellular regionGO:0055768.2NOTCH3, TIMP2, F13B, EDN3

Biological processes related to Varicose Veins according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ossificationGO:0015039.4FOXC2, MGP
2negative regulation of endopeptidase activityGO:0109519.1TIMP2, TIMP3
3cellular response to organic substanceGO:0713109.0TIMP2, TIMP3

Molecular functions related to Varicose Veins according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055098.9LTBP2, NOTCH3, MGP
2metalloendopeptidase inhibitor activityGO:0081918.8TIMP2, TIMP3

Products for genes affiliated with Varicose Veins

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  • Antibodies
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Sources for Varicose Veins

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet