Aliases & Classifications for Variola Major

Aliases & Descriptions for Variola Major:

Name: Variola Major 12 14 69
Smallpox 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050508
ICD9CM 35 050.0
UMLS 69 C1812609

Summaries for Variola Major

Disease Ontology : 12 A smallpox that results_in severe infection, located in skin, has material basis in Variola virus. The infection results_in_formation_of lesions.

MalaCards based summary : Variola Major, also known as smallpox, is related to smallpox and variola minor, and has symptoms including exanthema, fever and pruritus. An important gene associated with Variola Major is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Vaccines and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin and skin, and related phenotype is neoplasm.

Wikipedia : 71 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Related Diseases for Variola Major

Diseases related to Variola Major via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 smallpox 11.4
2 variola minor 11.3
3 ethmoid sinus cancer 10.2 IFNG TLR4
4 parkinson disease 11 10.2 IFNG TLR4
5 polyarteritis nodosa 10.2 IFNG TLR4
6 de quervain disease 10.2 IL2 TLR4
7 rickettsialpox 10.2 IFNG TLR4
8 benign deep fibrous histiocytoma 10.2 IFNG TLR3
9 caplan's syndrome 10.2 IFNG IL2
10 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG IL2
11 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL2
12 isolated growth hormone deficiency 10.1 IFNG TLR4
13 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 IFNG IL2
14 brain ischemia 10.1 IL2 TLR4
15 plantar wart 10.1 IFNG IL2
16 vestibule of mouth cancer 10.1 CD8A TLR3
17 clostridium difficile colitis 10.1 IFNG IL2
18 amyotrophic lateral sclerosis type 14 10.1 IFNG IL2
19 parametritis 10.1 IFNG IL2
20 spastic paraplegia 19 10.1 IFNG IL2
21 osteodysplasty precocious of danks mayne and kozlowski 10.1 CCL3 IFNG
22 ectothrix infectious disease 10.1 IFNG TLR4
23 cyclosporiasis 10.1 IFNG IL2
24 hyperlucent lung 10.1 IFNG TLR4
25 chronic thromboembolic pulmonary hypertension 10.1 IFNG IL2
26 hydrophthalmos 10.1 IFNG TLR3
27 venezuelan hemorrhagic fever 10.1 IFNG IL2
28 central nervous system origin vertigo 10.1 IFNG IL2
29 usher syndrome, type 2a 10.1 IFNG TLR4
30 hepatitis 10.1 IFNG IL2
31 aseptic meningitis 10.1 CD8A TLR4
32 acute myeloid leukemia with recurrent genetic anomaly 10.1 IFNG IL2
33 microcephaly 10.1 IFNG IL2
34 steatitis 10.1 CD8A IL2
35 oral cavity cancer 10.1 CD8A IFNG
36 strawberry gallbladder 10.1 IFNG IL2
37 neuropathy, hereditary thermosensitive 10.1 CD8A IL2
38 orbital osteomyelitis 10.1 IFNG IL2
39 active peptic ulcer disease 10.1 CCL3 CD8A
40 hereditary spastic paraplegia 10.1 IFNG TLR3 TLR4
41 autosomal recessive congenital methemoglobinemia 10.0 IFNG IL2
42 inclusion conjunctivitis 10.0 CD8A IL2
43 squamous cell papilloma of skin 10.0 CD8A IL2
44 thyroid hyalinizing trabecular adenoma 10.0 IFNG IL2 TLR3
45 rift valley fever 10.0 IFNG TLR4
46 gastroduodenitis 10.0 IFNG IL2 TLR3
47 abnormal retinal correspondence 10.0 IFNG IL2 TLR4
48 myiasis 10.0 IFNG IL2 TLR4
49 mansonelliasis 10.0 IFNG IL2 TLR4
50 dengue hemorrhagic fever 10.0 IFNG IL2 TLR4

Graphical network of the top 20 diseases related to Variola Major:



Diseases related to Variola Major

Symptoms & Phenotypes for Variola Major

UMLS symptoms related to Variola Major:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Variola Major:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 IFNG IL2 TLR3 TLR4

Drugs & Therapeutics for Variola Major

Drugs for Variola Major (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
2 Antibodies Phase 4,Phase 2,Phase 1
3 gamma-Globulins Phase 4,Phase 2,Phase 1
4 Immunoglobulins Phase 4,Phase 2,Phase 1
5 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
7
Glycerol Approved, Experimental Phase 2 56-81-5 753
8
Phenol Approved, Experimental Phase 2 108-95-2 996
9
Benzocaine Approved Phase 1, Phase 2 1994-09-7, 94-09-7 2337
10 tannic acid Approved, Nutraceutical Phase 1, Phase 2
11
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
12 Pharmaceutical Solutions Phase 1
13 Adjuvants, Immunologic Phase 1
14 Anti-Bacterial Agents Phase 1
15 Antibiotics, Antitubercular Phase 1
16 Anti-Infective Agents Phase 1
17 Antiviral Agents Phase 1
18 Interferon Inducers Phase 1
19 interferons Phase 1
20 Krestin Phase 1
21 Protective Agents Phase 1
22 Radiation-Protective Agents Phase 1
23 Keyhole-limpet hemocyanin Phase 1
24 Liver Extracts Phase 1
25 Carboxymethylcellulose Sodium Phase 1
26 Cathartics Phase 1
27 Gastrointestinal Agents Phase 1
28 Laxatives Phase 1
29 Poly I-C Phase 1
30 Poly ICLC Phase 1
31 diuretics Phase 1
32 Natriuretic Agents Phase 1
33 Interferon-gamma

Interventional clinical trials:

(show top 50) (show all 82)
id Name Status NCT ID Phase
1 Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®) Completed NCT00928577 Phase 4
2 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
3 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
4 VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection Enrolling by invitation NCT01374984 Phase 4
5 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3
6 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
9 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3
10 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
11 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
12 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
13 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
14 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
15 A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain) Completed NCT00998543 Phase 2
16 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
17 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2
18 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
19 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
20 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
21 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
22 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
23 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
24 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
25 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2
26 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
27 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
28 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
29 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
30 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2
31 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
32 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
33 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2
34 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
35 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
36 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
37 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2
38 Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis Completed NCT00723489 Phase 1, Phase 2
39 A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites Completed NCT00890760 Phase 1, Phase 2
40 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2
41 Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246 Completed NCT00907803 Phase 2
42 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Active, not recruiting NCT02038881 Phase 2
43 Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01266083 Phase 2
44 Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Terminated NCT00053508 Phase 2
45 Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults Completed NCT00079820 Phase 1
46 Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax® Completed NCT00042094 Phase 1
47 Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects Completed NCT00189969 Phase 1
48 Human Immune Responses Smallpox Completed NCT00068198 Phase 1
49 Safety and Immunogenicity of CJ-50300 Completed NCT00336635 Phase 1
50 Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) Subjects Completed NCT00565929 Phase 1

Search NIH Clinical Center for Variola Major

Genetic Tests for Variola Major

Anatomical Context for Variola Major

MalaCards organs/tissues related to Variola Major:

39
Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Variola Major:

18
Skin

Publications for Variola Major

Articles related to Variola Major:

(show all 27)
id Title Authors Year
1
Remaining questions about clinical variola major. ( 21470458 )
2011
2
Differentiation of Variola major and Variola minor variants by MGB-Eclipse probe melt curves and genotyping analysis. ( 19345728 )
2009
3
Studies of the suitability of fowlpox as a decontamination and thermal stability simulant for variola major. ( 20148078 )
2009
4
Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens. ( 17950773 )
2008
5
Structure-assisted discovery of Variola major H1 phosphatase inhibitors. ( 17505108 )
2007
6
Overproduction, purification, and biochemical characterization of the dual specificity H1 protein phosphatase encoded by variola major virus. ( 16793284 )
2006
7
Analysis of the nucleotide sequence of 23.8 kbp from the left terminus of the genome of variola major virus strain India-1967. ( 8725113 )
1996
8
Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses. ( 8612768 )
1996
9
Functional organization of variola major and vaccinia virus genomes. ( 7483290 )
1995
10
Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967. ( 7856312 )
1994
11
Analysis of the nucleotide sequence of 48 kbp of the variola major virus strain India-1967 located on the right terminus of the conservative genome region. ( 8030365 )
1994
12
Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975. ( 8184534 )
1994
13
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus. ( 1331292 )
1992
14
The pathogenicity of variola virus. A comparison of the growth of standard strains of variola major and variola minor viruses in cell cultures from human embryos. ( 6296226 )
1982
15
Facial scarring after varicella. A comparison with variola major and variola minor. ( 7315828 )
1981
16
Treatment of variola major with cytosine arabinoside. ( 162924 )
1975
17
Treatment of variola major with adenine arabinoside. ( 162923 )
1975
18
Variola major in West Pakistan. ( 5489073 )
1970
19
Chemoprophylaxis and chemotherapy in variola major. I. An assessment of CG 662 and Marboran in prophylaxis of contacts of variola major. ( 5824003 )
1969
20
Chemoprophylaxis and chemotherapy in variola major. II. Therapeutic assessment of CG 662 and Marboran in treatment of variola major in man. ( 5824004 )
1969
21
Assessment of an isothiazole thiosemicarbazone in the prophylaxis of contacts of variola major. ( 4160846 )
1966
22
An isothiazole thiosemicarbazone in the treatment of variola major in man. A controlled clinical trial and laboratory investigations. ( 4160845 )
1966
23
HYBRIDS DERIVED FROM THE VIRUSES OF VARIOLA MAJOR AND COWPOX. ( 14171267 )
1964
24
The chemotherapy of variola major infection. ( 13865851 )
1962
25
The laboratory differentiation between variola major and variola minor. ( 13888357 )
1961
26
Smallpox and alastrim; use of the chick embryo to distinguish between the viruses of variola major and variola minor. ( 13429852 )
1957
27
Haemorrhagic variola major (unvaccinated). ( 14807224 )
1951

Variations for Variola Major

Expression for Variola Major

Search GEO for disease gene expression data for Variola Major.

Pathways for Variola Major

Pathways related to Variola Major according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CCL3 CD8A IFNG IL2 TLR3 TLR4
2
Show member pathways
12.94 IFNG IL2 TLR3 TLR4
3
Show member pathways
12.54 IFNG IL2 TLR3 TLR4
4
Show member pathways
12.5 CCL3 IFNG IL2 TLR3 TLR4
5
Show member pathways
12.36 IFNG IL2 TLR4
6
Show member pathways
12.2 CD8A IFNG IL2
7 12.2 CD8A IFNG IL2 TLR3
8
Show member pathways
12.04 IFNG TLR3 TLR4
9 11.95 IFNG TLR3 TLR4
10
Show member pathways
11.81 IL2 TLR3 TLR4
11 11.78 IFNG IL2 TLR4
12 11.75 CD8A IFNG IL2
13
Show member pathways
11.68 IFNG TLR3 TLR4
14 11.61 CCL3 IFNG TLR4
15 11.57 CCL3 IFNG TLR4
16
Show member pathways
11.51 CCL3 CD8A IFNG IL2
17 11.49 CD8A IFNG IL2
18
Show member pathways
11.46 IFNG IL2
19 11.35 IFNG IL2
20 11.33 IFNG TLR4
21
Show member pathways
11.33 CD8A IFNG IL2
22 11.31 IFNG IL2
23 11.31 IFNG TLR4
24 11.29 IFNG IL2
25
Show member pathways
11.29 IFNG IL2 TLR3 TLR4
26 11.13 IFNG IL2
27 11.1 CD8A IL2
28 11.08 IFNG IL2
29 11.04 IFNG IL2
30
Show member pathways
11.03 CCL3 IFNG IL2
31 11 IFNG IL2
32 10.96 TLR3 TLR4
33 10.83 CCL3 CD8A IFNG IL2

GO Terms for Variola Major

Cellular components related to Variola Major according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD8A IFNG TLR4

Biological processes related to Variola Major according to GeneCards Suite gene sharing:

(show all 42)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.97 IFNG IL2 TLR3 TLR4
2 inflammatory response GO:0006954 9.86 CCL3 TLR3 TLR4
3 immune system process GO:0002376 9.85 CD8A IL2 TLR3 TLR4
4 defense response to bacterium GO:0042742 9.8 IFNG TLR3 TLR4
5 defense response to virus GO:0051607 9.78 CD8A IFNG TLR3
6 positive regulation of protein phosphorylation GO:0001934 9.75 IFNG IL2 TLR3
7 positive regulation of gene expression GO:0010628 9.73 CCL3 IFNG TLR3 TLR4
8 immune response GO:0006955 9.72 CCL3 CD8A IFNG IL2 TLR4
9 positive regulation of T cell proliferation GO:0042102 9.69 IFNG IL2
10 cellular response to interferon-gamma GO:0071346 9.68 CCL3 TLR3
11 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.68 TLR3 TLR4
12 antigen processing and presentation GO:0019882 9.68 CD8A IFNG
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 IFNG IL2
14 toll-like receptor signaling pathway GO:0002224 9.67 TLR3 TLR4
15 positive regulation of interferon-gamma production GO:0032729 9.66 IL2 TLR4
16 positive regulation of interleukin-6 production GO:0032755 9.66 TLR3 TLR4
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG TLR4
18 extrinsic apoptotic signaling pathway GO:0097191 9.65 IFNG TLR3
19 positive regulation of B cell proliferation GO:0030890 9.65 IL2 TLR4
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.64 CCL3 TLR4
21 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.64 TLR3 TLR4
22 positive regulation of interferon-beta production GO:0032728 9.63 TLR3 TLR4
23 positive regulation of interleukin-8 production GO:0032757 9.62 TLR3 TLR4
24 positive regulation of interleukin-1 beta secretion GO:0050718 9.62 CCL3 IFNG
25 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 TLR3 TLR4
26 positive regulation of calcium-mediated signaling GO:0050850 9.6 CCL3 CD8A
27 positive regulation of chemokine production GO:0032722 9.59 TLR3 TLR4
28 necroptotic process GO:0070266 9.58 TLR3 TLR4
29 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.57 TLR3 TLR4
30 I-kappaB phosphorylation GO:0007252 9.56 TLR3 TLR4
31 negative regulation of interleukin-17 production GO:0032700 9.54 IFNG TLR4
32 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IFNG TLR3
33 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 IFNG IL2
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IFNG TLR4
35 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.48 TLR3 TLR4
36 positive regulation of interferon-beta biosynthetic process GO:0045359 9.46 TLR3 TLR4
37 positive regulation of interleukin-12 production GO:0032735 9.43 IFNG TLR3 TLR4
38 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.4 IFNG TLR4
39 regulation of dendritic cell cytokine production GO:0002730 9.37 TLR3 TLR4
40 negative regulation of osteoclast differentiation GO:0045671 9.33 CCL3 TLR3 TLR4
41 positive regulation of inflammatory response GO:0050729 9.26 CCL3 IL2 TLR3 TLR4
42 positive regulation of tumor necrosis factor production GO:0032760 8.92 CCL3 IFNG TLR3 TLR4

Molecular functions related to Variola Major according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL3 IFNG IL2

Sources for Variola Major

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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