MCID: VSC006
MIFTS: 43

Vascular Cancer

Categories: Cancer diseases, Blood diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Vascular Cancer

MalaCards integrated aliases for Vascular Cancer:

Name: Vascular Cancer 12 14
Malignant Vascular Neoplasm 12 69
Renal Vein Leiomyosarcoma 12 69
Blood Vessel Tumors 12 51
Vascular Neoplasms 41 69
Malignant Tumor of Pulmonary Artery 12
Pulmonary Artery Malignant Neoplasm 12
Malignant Neoplasm of Great Vessels 69
Malignant Tumor of Pulmonary Vein 12
Pulmonary Vein Malignant Neoplasm 12
Leiomyosarcoma of the Renal Vein 12
Blood Vessel Tumour Disorder 12
Malignant Great Vessel Tumor 12
Neoplasms, Vascular Tissue 69
Malignant Vascular Tumor 12
Neoplasm of Great Vessel 12
Vascular Tissue Neoplasm 12
Haemangiomatous Tumour 12
Blood Vessel Neoplasm 12
Blood Vessel Cancer 69
Blood Vessel Tumor 12
Vascular Tumors 12

Classifications:



Summaries for Vascular Cancer

Disease Ontology : 12 A cardiovascular cancer that is located in blood vessels.

MalaCards based summary : Vascular Cancer, also known as malignant vascular neoplasm, is related to hemangioendothelioma and kaposiform hemangioendothelioma. An important gene associated with Vascular Cancer is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Cyclophosphamide and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include blood vessels, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Vascular Cancer

Diseases related to Vascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 32.0 CAMTA1 FLI1 FLT4 KDR
2 kaposiform hemangioendothelioma 31.9 FLI1 FLT4 KDR VWF
3 breast angiosarcoma 31.4 HBA1 KIT
4 glomeruloid hemangioma 31.0 ENG FLT1 HBA1 VEGFA
5 angiosarcoma 30.6 FLI1 FLT1 FLT4 KDR KIT VEGFA
6 hemangioma 29.4 FGF2 FLT4 KDR VEGFA
7 spindle cell hemangioma 11.2
8 carotid body cancer 10.8
9 hemifacial spasm 10.5 FLT4 VEGFA
10 hemangioma, capillary infantile 10.4 FLT4 KDR
11 chronic myocardial ischemia 10.4 FGF2 VEGFA
12 squamous cell carcinoma of the hypopharynx 10.4 ENG VEGFA
13 infiltrating angiolipoma 10.3 VEGFA VWF
14 microcystic meningioma 10.3 FLT1 VEGFA
15 histiocytoid hemangioma 10.3 CAMTA1 HBA1
16 lymphangioma 10.3 FLT4 KDR VEGFA
17 kuhnt-junius degeneration 10.3 KDR VEGFA
18 pediatric angiosarcoma 10.3 HBA1 VEGFA
19 cancer-associated retinopathy 10.3 FLT1 VEGFA
20 hobnail hemangioma 10.3 FLT4 HBA1
21 bone squamous cell carcinoma 10.3 ENG KDR
22 conventional angiosarcoma 10.3 CAMTA1 HBA1
23 radiation proctitis 10.3 FGF2 KDR VEGFA
24 angiokeratoma circumscriptum 10.3 FLT1 KDR VEGFA
25 lipodermatosclerosis 10.3 FLT1 VEGFA
26 acute hemorrhagic leukoencephalitis 10.3 FLT1 KDR VEGFA
27 placental insufficiency 10.2 FLT1 KDR VEGFA
28 exudative vitreoretinopathy 1 10.2 FLT1 KDR VEGFA
29 pulmonary vein stenosis 10.2 KDR KIT
30 placenta accreta 10.2 FLT1 KDR
31 microvascular complications of diabetes 1 10.2 FGF2 FLT1 VEGFA
32 desmoid tumor 10.2 KIT PDGFRB
33 hypereosinophilic syndrome, idiopathic 10.2 KIT PDGFRB
34 twin-to-twin transfusion syndrome 10.2 ENG FLT1
35 spleen angiosarcoma 10.2 HBA1 VWF
36 astrocytoma 10.1 KDR PDGFRB VEGFA
37 skin hemangioma 10.1 HBA1 KDR VEGFA
38 interstitial emphysema 10.1 FLT1 FLT4 HBA1
39 epithelioid hemangioendothelioma 10.1 CAMTA1 FLT1 KDR VEGFA
40 kidney cancer 10.1 FGF2 FLT4 KDR VEGFA
41 arteriovenous malformations of the brain 10.1 ENG KDR
42 hereditary hemorrhagic telangiectasia 10.1 ENG VEGFA VWF
43 posterior uveal melanoma 10.1 THBS1 VEGFA
44 8p11 myeloproliferative syndrome 10.0 KDR KIT PDGFRB
45 fibrosarcoma of bone 10.0 KDR KIT PDGFRB
46 microvascular complications of diabetes 5 10.0 FGF2 FLT1 KDR VEGFA
47 mast-cell sarcoma 10.0 ANPEP KIT
48 angiomyoma 10.0 HBA1 KIT
49 liver angiosarcoma 10.0 CAMTA1 HBA1 VWF
50 macular degeneration, age-related, 1 10.0 FGF2 FLT1 KDR VEGFA

Graphical network of the top 20 diseases related to Vascular Cancer:



Diseases related to Vascular Cancer

Symptoms & Phenotypes for Vascular Cancer

MGI Mouse Phenotypes related to Vascular Cancer:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.35 VEGFA THBS1 VWF KDR PDGFRB KIT
2 hematopoietic system MP:0005397 10.25 VEGFA THBS1 VWF KDR PDGFRB KIT
3 growth/size/body region MP:0005378 10.22 THBS1 PDGFRB VEGFA FLT4 KIT KDR
4 cellular MP:0005384 10.21 VWF THBS1 PDGFRB VEGFA KIT KDR
5 homeostasis/metabolism MP:0005376 10.19 VWF THBS1 PDGFRB VEGFA FLT4 KIT
6 immune system MP:0005387 10.18 THBS1 VEGFA VWF KDR PDGFRB KIT
7 mortality/aging MP:0010768 10.18 VEGFA THBS1 VWF KDR PDGFRB KIT
8 embryo MP:0005380 10.14 VEGFA KDR PDGFRB KIT FLT4 FLI1
9 digestive/alimentary MP:0005381 10.09 VWF THBS1 VEGFA PDGFRB FLT4 KIT
10 muscle MP:0005369 10.07 VEGFA THBS1 KDR PDGFRB KIT FLT4
11 integument MP:0010771 10.06 THBS1 VEGFA KDR PDGFRB FLT4 KIT
12 nervous system MP:0003631 9.96 VWF VEGFA KDR PDGFRB KIT CAMTA1
13 liver/biliary system MP:0005370 9.91 THBS1 VEGFA FLT4 KIT KDR FLI1
14 neoplasm MP:0002006 9.8 THBS1 VEGFA KIT CAMTA1 FLI1 FGF2
15 normal MP:0002873 9.76 VEGFA KDR PDGFRB FLT4 KIT CAMTA1
16 reproductive system MP:0005389 9.61 VEGFA THBS1 PDGFRB KIT FLT4 CAMTA1
17 vision/eye MP:0005391 9.23 VEGFA THBS1 KDR PDGFRB KIT ANPEP

Drugs & Therapeutics for Vascular Cancer

Drugs for Vascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
2
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
3 Adrenergic Agents Phase 1, Phase 2
4 Adrenergic Antagonists Phase 1, Phase 2
5 Adrenergic beta-Antagonists Phase 1, Phase 2
6 Anti-Arrhythmia Agents Phase 1, Phase 2
7 Antihypertensive Agents Phase 1, Phase 2
8 Neurotransmitter Agents Phase 1, Phase 2
9 Vasodilator Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Tria Not yet recruiting NCT02732678 Phase 1, Phase 2 PROPRANOLOL

Search NIH Clinical Center for Vascular Cancer

Cochrane evidence based reviews: vascular neoplasms

Genetic Tests for Vascular Cancer

Anatomical Context for Vascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Vascular Cancer:

18
Blood Vessels

Publications for Vascular Cancer

Articles related to Vascular Cancer:

# Title Authors Year
1
Research gives hope to patients with rare vascular cancer. Cleveland Clinic researchers suggest that their work could lead to breakthrough in treating other cancers. ( 22272406 )
2011
2
New strategies in anti-vascular cancer therapy. ( 10469169 )
1999
3
Anti-vascular cancer therapy: is it a dream or reality? ( 1720044 )
1991

Variations for Vascular Cancer

Expression for Vascular Cancer

Search GEO for disease gene expression data for Vascular Cancer.

Pathways for Vascular Cancer

Pathways related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 FGF2 FLT1 FLT4 KDR KIT PDGFRB
2
Show member pathways
13.31 FGF2 FLT1 FLT4 KDR KIT PDGFRB
3
Show member pathways
13.23 FGF2 FLT1 FLT4 KDR KIT PDGFRB
4
Show member pathways
13.21 FGF2 FLT1 FLT4 KDR KIT PDGFRB
5
Show member pathways
13.18 FGF2 FLT1 FLT4 KDR KIT PDGFRB
6
Show member pathways
12.98 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7
Show member pathways
12.96 FGF2 KDR KIT PDGFRB VEGFA
8
Show member pathways
12.96 FGF2 FLT1 FLT4 KDR KIT PDGFRB
9
Show member pathways
12.91 FLT1 FLT4 KDR KIT PDGFRB
10
Show member pathways
12.81 FLT1 FLT4 KDR PDGFRB THBS1 VEGFA
11 12.77 FGF2 FLT4 KIT PDGFRB VEGFA
12 12.68 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13
Show member pathways
12.63 FGF2 FLT1 FLT4 KDR KIT PDGFRB
14
Show member pathways
12.6 FGF2 FLT1 FLT4 KDR
15
Show member pathways
12.52 FLT1 FLT4 KDR VEGFA
16
Show member pathways
12.5 FGF2 FLT1 FLT4 KDR KIT PDGFRB
17
Show member pathways
12.42 FLT1 FLT4 KDR PDGFRB
18
Show member pathways
12.37 FLT1 FLT4 KDR PDGFRB
19
Show member pathways
12.31 FLT1 FLT4 KDR VEGFA
20
Show member pathways
12.31 FGF2 FLT1 FLT4 KDR VEGFA
21 12.25 FGF2 KDR THBS1 VEGFA
22
Show member pathways
12.18 FGF2 FLT1 KDR VEGFA
23
Show member pathways
12.14 FLT1 FLT4 KDR PDGFRB
24
Show member pathways
12.04 KDR THBS1 VWF
25 12 FGF2 KDR PDGFRB VEGFA
26 11.96 FGF2 FLT1 FLT4 KDR KIT PDGFRB
27
Show member pathways
11.93 FLT1 KDR PDGFRB VEGFA
28 11.92 ANPEP ENG KIT
29 11.82 ENG FGF2 KIT
30
Show member pathways
11.79 FLT1 FLT4 KDR VEGFA
31
Show member pathways
11.75 FLT1 FLT4 KDR KIT PDGFRB
32
Show member pathways
11.59 FLT1 FLT4 KDR KIT PDGFRB
33 11.54 ANPEP FGF2 KDR KIT
34 11.5 FGF2 KDR VEGFA
35 11.48 FGF2 KIT VEGFA
36 11.45 FGF2 KDR VEGFA
37
Show member pathways
11.4 KDR PDGFRB VEGFA
38 11.29 FLT1 KDR VEGFA
39 11.17 ENG FGF2 FLT1 FLT4 KDR PDGFRB
40 11.15 FGF2 FLT1 VEGFA
41 11.14 FGF2 FLT1 KDR VEGFA
42 11.06 FGF2 FLT1 FLT4 KDR PDGFRB VEGFA
43 10.93 FGF2 FLT1 FLT4 KDR KIT PDGFRB
44
Show member pathways
10.87 FLT1 FLT4 KDR VEGFA

GO Terms for Vascular Cancer

Cellular components related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 FGF2 FLT1 FLT4 HBA1 KDR THBS1
2 cell surface GO:0009986 9.65 ENG KIT PDGFRB THBS1 VEGFA
3 receptor complex GO:0043235 9.58 ENG FLT1 FLT4
4 external side of plasma membrane GO:0009897 9.46 ANPEP ENG KIT THBS1
5 platelet alpha granule GO:0031091 9.37 THBS1 VWF
6 extracellular space GO:0005615 9.23 ANPEP ENG FGF2 FLT1 HBA1 KIT
7 platelet alpha granule lumen GO:0031093 9.13 THBS1 VEGFA VWF

Biological processes related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.94 FGF2 KDR THBS1 VWF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 FGF2 FLT4 KDR PDGFRB
3 protein autophosphorylation GO:0046777 9.93 FLT1 FLT4 KDR KIT PDGFRB
4 positive regulation of protein phosphorylation GO:0001934 9.91 ENG FLT4 KDR VEGFA
5 positive regulation of protein kinase B signaling GO:0051897 9.91 FGF2 KIT PDGFRB THBS1
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.89 FLT1 FLT4 KDR KIT PDGFRB
7 chemotaxis GO:0006935 9.88 FGF2 FLT1 PDGFRB
8 positive regulation of MAPK cascade GO:0043410 9.88 FLT1 FLT4 KDR KIT
9 positive regulation of cell migration GO:0030335 9.88 FLT1 KDR KIT PDGFRB THBS1 VEGFA
10 regulation of cell shape GO:0008360 9.87 KDR KIT VEGFA
11 platelet degranulation GO:0002576 9.87 THBS1 VEGFA VWF
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.87 FLT1 FLT4 KDR VEGFA
13 activation of MAPK activity GO:0000187 9.86 FGF2 KIT THBS1
14 positive regulation of endothelial cell proliferation GO:0001938 9.86 FGF2 FLT4 KDR VEGFA
15 positive regulation of cell proliferation GO:0008284 9.86 FGF2 FLT1 FLT4 KDR KIT PDGFRB
16 phosphatidylinositol phosphorylation GO:0046854 9.85 FGF2 KIT PDGFRB
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 FLT1 KDR KIT PDGFRB
18 peptidyl-tyrosine phosphorylation GO:0018108 9.85 FGF2 FLT1 FLT4 KDR KIT PDGFRB
19 positive regulation of endothelial cell migration GO:0010595 9.83 FLT4 KDR THBS1 VEGFA
20 vasculogenesis GO:0001570 9.82 ENG KDR VEGFA
21 positive regulation of blood vessel endothelial cell migration GO:0043536 9.78 FGF2 KDR THBS1 VEGFA
22 sprouting angiogenesis GO:0002040 9.77 ENG FLT4 THBS1
23 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.76 FGF2 FLT1 KIT PDGFRB
24 cell migration involved in sprouting angiogenesis GO:0002042 9.75 FGF2 KDR VEGFA
25 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 FLT1 FLT4 KDR VEGFA
26 positive regulation of MAP kinase activity GO:0043406 9.72 FGF2 FLT1 KIT PDGFRB VEGFA
27 positive regulation of focal adhesion assembly GO:0051894 9.7 KDR VEGFA
28 positive regulation of collagen biosynthetic process GO:0032967 9.7 ENG PDGFRB
29 artery morphogenesis GO:0048844 9.7 ENG VEGFA
30 megakaryocyte development GO:0035855 9.69 FLI1 KIT
31 embryonic morphogenesis GO:0048598 9.69 FGF2 FLT1
32 vascular endothelial growth factor signaling pathway GO:0038084 9.69 FLT1 FLT4 KDR
33 embryonic hemopoiesis GO:0035162 9.68 KDR KIT
34 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 FLT1 VEGFA
35 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
36 positive regulation of chemotaxis GO:0050921 9.66 PDGFRB THBS1
37 positive regulation of protein kinase C signaling GO:0090037 9.65 FLT4 VEGFA
38 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.63 ENG KIT
39 positive regulation of angiogenesis GO:0045766 9.63 ENG FGF2 FLT1 KDR THBS1 VEGFA
40 regulation of cGMP metabolic process GO:0030823 9.62 THBS1 VEGFA
41 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.62 KDR VEGFA
42 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.6 PDGFRB VEGFA
43 angiogenesis GO:0001525 9.5 ANPEP ENG FGF2 FLT1 FLT4 KDR
44 positive regulation of phospholipase C activity GO:0010863 8.92 FGF2 FLT1 KIT PDGFRB
45 multicellular organism development GO:0007275 10.15 ANPEP FGF2 FLT1 KDR PDGFRB VEGFA
46 cell differentiation GO:0030154 10.12 ANPEP FGF2 FLI1 FLT1 KDR VEGFA
47 phosphorylation GO:0016310 10.07 FLT1 FLT4 KDR KIT PDGFRB
48 protein phosphorylation GO:0006468 10.06 FLT1 FLT4 KDR KIT PDGFRB
49 negative regulation of apoptotic process GO:0043066 10.05 FLT4 KDR PDGFRB THBS1 VEGFA

Molecular functions related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.92 ENG FLT4 KIT VEGFA VWF
2 kinase activity GO:0016301 9.83 FLT1 FLT4 KDR KIT PDGFRB
3 protein kinase activity GO:0004672 9.77 FLT1 FLT4 KDR KIT PDGFRB
4 heparin binding GO:0008201 9.71 FGF2 THBS1 VEGFA
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.67 FGF2 KIT PDGFRB
6 integrin binding GO:0005178 9.65 KDR THBS1 VWF
7 fibronectin binding GO:0001968 9.55 THBS1 VEGFA
8 transforming growth factor beta binding GO:0050431 9.51 ENG THBS1
9 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGF2 KIT PDGFRB
10 platelet-derived growth factor receptor binding GO:0005161 9.46 PDGFRB VEGFA
11 growth factor binding GO:0019838 9.43 FLT1 FLT4 KDR
12 protein tyrosine kinase activity GO:0004713 9.43 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.4 KDR KIT
14 vascular endothelial growth factor-activated receptor activity GO:0005021 9.33 FLT1 FLT4 KDR
15 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 FLT1 FLT4 KDR KIT PDGFRB

Sources for Vascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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