MCID: VSC002
MIFTS: 57

Vascular Dementia malady

Neuronal diseases, Cardiovascular diseases categories

Summaries for Vascular Dementia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards: Vascular Dementia, also known as dementia, vascular, is related to dementia and vascular disease. An important gene associated with Vascular Dementia is TNF (tumor necrosis factor), and among its related pathways is MSP-RON Signaling. The compounds rivastigmine and metrifonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Vascular dementia or \"multi-infarct dementia\" is dementia caused by problems in the supply of blood to... more...

Aliases & Classifications for Vascular Dementia

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Cardiovascular diseases


Aliases & Descriptions:

vascular dementia 8 10
dementia, vascular 46 60
multi infarct dementia 8
multi-infarct dementia 60
multifocal dementia 8
dementia vascular 44


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Disease Ontology8 DOID:8725
MeSH34 D015161
NCIt39 C34522
ICD1025 F01

Related Diseases for Vascular Dementia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.0BCHE, APOE, CHRM1, NOTCH3, ACHE
2vascular disease31.7BCHE, TNF
3alzheimer's disease31.6KLK6, APOE, AOC3, NEFL, CHRM1, NOTCH3
4cerebrovascular disease30.8APOE, NOTCH3, ACHE
5cadasil30.7APOE, AOC3, AVP, NOTCH3
6hypertension30.6AVP, APOE, KLK1
7cerebral amyloid angiopathy30.4APOE, AOC3
8stroke, ischemic30.4NOTCH3, AOC3
9diabetes mellitus30.4TNF, APOE, AOC3, BCHE
10lewy body dementia30.3APOE
11parkinson's disease30.1APOE
12binswanger's disease30.1ACHE, NOTCH3, APOE
13frontotemporal dementia30.1ACHE, APOE
14schizophrenia29.9NEFL, CHRM1, ACHE, BCHE
15type 2 diabetes mellitus29.9BCHE, ACHE, AOC3, APOE
16obesity29.9TNF, APOE, AOC3, SREBF2, BCHE
17cerebritis10.7
18neuronitis10.3
19brain disease10.3
20vascular cancer10.3
21hyperhomocysteinemia10.2
22atherosclerosis10.2
23vertebrobasilar insufficiency10.2
24temporal arteritis10.2
25peripheral vascular disease10.1
26capgras syndrome10.1
27parametritis10.1
28normal pressure hydrocephalus10.1
29cerebral arterial disease10.1
30hydrocephalus10.1
31ischemia10.1
32pneumonia10.1
33hyperlipidemia type 310.1
34ovarian cancer10.0KLK6, KLK1
35neuropathy10.0NEFL
36breast cancer10.0KLK6, TNFSF14, ANGPT4, BCHE
37progressive supranuclear palsy10.0ACHE, NEFL, APOE
38prion disease10.0BCHE, AVP
39amyotrophic lateral sclerosis10.0NEFL
40memory impairment10.0BCHE, ACHE, APOE
41prostate cancer10.0KLK6, AOC3, CHRM1, SREBF2
42hypertriglyceridemia10.0APOE, BCHE
43myopathy10.0NEFL, NOTCH3, ACHE
44myasthenia gravis10.0ACHE, BCHE
45abdominal aortic aneurysm10.0APOE
46diabetic retinopathy10.0AOC3, OCLN
47familial hyperlipidemia10.0APOE, ACHE, SREBF2
48pick's disease10.0ACHE, APOE
49hypothyroidism10.0AVP
50colon cancer10.0ACHE, TNFSF14

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Clinical Features for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Dementia

Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Search CenterWatch for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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32MalaCards
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MalaCards organs/tissues related to Vascular Dementia:

32
Brain, Testes, Cortex, Temporal lobe, Endothelial, Heart, Cerebellum, Hypothalamus, Spleen, Kidney, Caudate nucleus, Parietal lobe

Animal Models for Vascular Dementia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Vascular Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3GSTO1, APOE, OCLN, CHRM1, AVP, NOTCH3

Publications for Vascular Dementia

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50PubMed
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Articles related to Vascular Dementia:

(show top 50)    (show all 648)
idTitleAuthorsYear
1
Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia. (23701539)
2014
2
Nitrogen dioxide (NO(2)) pollution as a potential risk factor for developing vascular dementia and its synaptic mechanisms. (23535468)
2013
3
Serum Homocysteine, Dehydroepiandrosterone Sulphate and Lipoprotein (a) in Alzheimer's Disease and Vascular Dementia. (23696950)
2013
4
Fluoxetine enhances Brain Derived Neurotropic Factor Serum Concentration and Cognition in Patients with Vascular Dementia. (23962390)
2013
5
Seizures in patients with Alzheimer's disease or vascular dementia: a population-based nested case-control analysis. (23215680)
2013
6
Ifenprodil for emotional incontinence in patients with vascular dementia: two case reports. (23288243)
2013
7
Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia. (23254629)
2013
8
Neuropsychiatric symptoms in Alzheimer's disease and vascular dementia. (23001706)
2013
9
Biomarkers of oxidative stress in vascular dementia patients. (22384487)
2012
10
Influences of electro-acupuncture at related jing-well points in rats with vascular dementia. (22876450)
2012
11
The profile of hippocampal metabolites differs between Alzheimer's disease and subcortical ischemic vascular dementia, as measured by proton magnetic resonance spectroscopy. (22314267)
2012
12
Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761Ar in Alzheimer's disease and vascular dementia: results from a randomised controlled trial. (22086747)
2012
13
Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain. (22705146)
2012
14
Nimodipine improves regional cerebral blood flow and suppresses inflammatory factors in the hippocampus of rats with vascular dementia. (22906276)
2012
15
Genome-wide association study of vascular dementia. (22116812)
2012
16
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
17
Electroacupuncture protected pyramidal cells in hippocampal CA1 region of vascular dementia rats by inhibiting the expression of p53 and Noxa. (20950325)
2011
18
Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats. (21777659)
2011
19
Citicoline in vascular cognitive impairment and vascular dementia after stroke. (21164117)
2011
20
Increased neural progenitors in vascular dementia. (20138403)
2011
21
Distinguishing Alzheimer's disease from vascular dementia: an exploration of five cognitive domains. (20504211)
2010
22
Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia. (20502016)
2010
23
Are the indices of the RBANS sufficient for differentiating Alzheimer's disease and subcortical vascular dementia? (20430863)
2010
24
Prevalence and pathology of vascular dementia in the oldest-old. (21504129)
2010
25
Predictors of the progression of dementia severity in brazilian patients with Alzheimer's disease and vascular dementia. (20798750)
2010
26
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
27
Comparison of Alzheimer's disease with vascular dementia and non-dementia using specific voxel-based Z score maps. (19205835)
2009
28
Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions. (19184337)
2009
29
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. (18674411)
2008
30
Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia. (18597785)
2008
31
Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. (18083315)
2008
32
Treatment of vascular dementia: the route of prevention. (18756085)
2008
33
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. (18691432)
2008
34
Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project. (17573076)
2007
35
Subcortical ischemic vascular dementia. (17659187)
2007
36
Galantamine treatment of vascular dementia: a randomized trial. (17664404)
2007
37
High risk neurological gait syndrome and vascular dementia. (17541695)
2007
38
Vascular dementia: clinical, neuroradiologic and neuropathologic aspects. (18091672)
2007
39
Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)
2006
40
The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia. (16990569)
2006
41
Protective effects of breviscapine on ischemic vascular dementia in rats. (16946502)
2006
42
Loss of cholinergic pathways in vascular dementia of the Binswanger type. (15785029)
2005
43
Metabolic alterations in the hypothalamus and basal forebrain in vascular dementia. (15624761)
2004
44
Tumor necrosis factor alpha polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population. (12782345)
2003
45
Acetylcholinesterase inhibitors for vascular dementia and Alzheimer's disease combined with cerebrovascular disease. (12574580)
2003
46
The association between APOE and dementia does not seem to be mediated by vascular factors. (10668701)
2000
47
Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. (10940674)
2000
48
Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. (9520135)
1997
49
Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)
1996
50
Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. (7964823)
1994

Genetic Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Dementia

Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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51QIAGEN
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Pathways related to Vascular Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4TNF, KLK6, KLK1

Compounds for genes affiliated with Vascular Dementia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Vascular Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1rivastigmine44 1111.9APOE, ACHE, BCHE
2metrifonate4410.9BCHE, ACHE, APOE
3ethopropazine44 1111.9ACHE, BCHE, CHRM1
4tacrine44 1111.9BCHE, APOE, ACHE
5Methylphosphinic Acid1110.9BCHE, ACHE
6ambenonium44 1111.9ACHE, BCHE
7donepezil44 11 2412.9ACHE, BCHE, APOE, CHRM1
8thiocholine4410.9BCHE, ACHE
9galantamine44 49 1112.9BCHE, ACHE, APOE
10succinylcholine44 28 1112.9BCHE, ACHE, CHRM1
11Isoflurophate1110.9BCHE, ACHE
12scopolamine44 28 11 2413.9ACHE, BCHE, CHRM1
13alpha-solanine4410.9BCHE, ACHE
14Demecarium1110.9BCHE, ACHE
15Cyclopentolate1110.9CHRM1, BCHE
16obidoxime4410.9BCHE, ACHE
17fasciculin4410.9ACHE, BCHE
18galanthamine hydrobromide5910.9BCHE, ACHE
19donepezil hydrochloride5910.9BCHE, ACHE
20pralidoxime44 1111.8ACHE, BCHE
21isomalathion4410.8ACHE, BCHE
22rivastigmine tartrate5910.8BCHE, ACHE
23acephate59 4411.8ACHE, BCHE
24o-nitroacetanilide4410.8BCHE, ACHE
25acetylthiocholine4410.8BCHE, ACHE
26benzoylcholine4410.8ACHE, BCHE
27butyrylcholine4410.8ACHE, BCHE
28butyrylthiocholine44 1111.8ACHE, BCHE
29echothiophate44 1111.8BCHE, ACHE
30arginine4410.8BCHE, NOTCH3, SREBF2, AVP, CHRM1, APOE
31choline ester4410.8ACHE, BCHE
32bw 284 c 514410.8BCHE, ACHE
33neostigmine44 1111.8BCHE, ACHE
34glycopyrrolate44 1111.8CHRM1, BCHE
35tiapride4410.8BCHE, ACHE
36methamidophos4410.7BCHE, ACHE
37aldicarb4410.7BCHE, ACHE
38carbofuran4410.7BCHE, ACHE
39decamethonium44 1111.7BCHE, ACHE
40bambuterol44 1111.7BCHE, ACHE
41edrophonium44 1111.7BCHE, ACHE
42phenserine44 5911.7ACHE, BCHE
43simvastatin44 49 59 28 11 2415.6SREBF2, BCHE, APOE, TNF
44fenitrothion4410.6ACHE, BCHE
45nicotine44 49 28 1113.5ACHE, APOE, BCHE, CHRM1
46serine4410.5KLK6, TNF, APOE, KLK1, AVP, ACHE
47mivacurium44 1111.5BCHE, ACHE
48gallamine44 2811.5CHRM1, ACHE
49mipafox4410.4BCHE, ACHE
50huperzine a4410.2ACHE, BCHE

GO Terms for genes affiliated with Vascular Dementia

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16Gene Ontology
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Cellular components related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:03042510.4ACHE, AVP, CHRM1, APOE
2extracellular spaceGO:00561510.3BCHE, TNFSF14, TNF, APOE, ANGPT4, AVP
3extracellular regionGO:00557610.1KLK6, TNF, APOE, ANGPT4, AVP, NOTCH3

Biological processes related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.5BCHE, ACHE, APOE
2positive regulation of membrane protein ectodomain proteolysisGO:05104410.5APOE, TNF
3amyloid precursor protein metabolic processGO:04298210.4ACHE, KLK6
4choline metabolic processGO:01969510.4ACHE, BCHE
5negative regulation of blood vessel endothelial cell migrationGO:04353710.1ANGPT4, APOE

Molecular functions related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholinesterase activityGO:00410410.5BCHE, ACHE
2beta-amyloid bindingGO:00154010.3BCHE, ACHE, APOE
3acetylcholinesterase activityGO:00399010.2BCHE, ACHE

Products for genes affiliated with Vascular Dementia

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Sources for Vascular Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet