MCID: VSC002
MIFTS: 48

Vascular Dementia malady

Mental diseases, Cardiovascular diseases categories

Aliases & Classifications for Vascular Dementia

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Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 55SNOMED-CT, 38NCIt, 33MeSH, 25ICD10
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Vascular Dementia, Aliases & Descriptions:

Name: Vascular Dementia 9 11
Multi Infarct Dementia 9
Multi-Infarct Dementia 60
 
Multifocal Dementia 9
Dementia, Vascular 60
Dementia Vascular 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:8725
NCIt38 C34522
MeSH33 D015161
ICD1025 F01

Summaries for Vascular Dementia

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Disease Ontology:9 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards based summary: Vascular Dementia, also known as multi infarct dementia, is related to dementia and cerebrovascular disease. An important gene associated with Vascular Dementia is FAM134B (family with sequence similarity 134, member B). The compounds ambenonium and acephate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Wikipedia:63 Vascular dementia, also known as multi-infarct dementia (MID) and vascular cognitive impairment (VCI),... more...

Related Diseases for Vascular Dementia

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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.6BCHE, CHRM1, NOTCH3, APOE, ACHE
2cerebrovascular disease31.0APOE, NOTCH3, ACHE
3hyperhomocysteinemia30.6BCHE, APOE
4binswanger's disease30.6APOE, ACHE, NOTCH3
5dementia, frontotemporal30.4APOE, ACHE
6brain disease30.1BCHE, NOTCH3
7alzheimer disease30.1CHRM1, NOTCH3, GSTO1, APOE, BCHE, ACHE
8schizophrenia29.9CHRM1, BCHE, ACHE
9cerebritis10.8
10cadasil10.5
11abdominal aortic aneurysm10.4APOE
12neuronitis10.4
13cerebral amyloid angiopathy10.4
14supranuclear palsy, progressive10.3ACHE, APOE
15anencephaly10.3BCHE, ACHE
16pick disease10.3ACHE, APOE
17alzheimer disease-210.3APOE, BCHE
18hirschsprung disease 110.2ACHE, BCHE
19atherosclerosis10.2
20ischemia10.2
21pneumonia10.2
22vascular disease10.2
23neural tube defects10.2BCHE, ACHE
24myasthenia gravis10.2ACHE, BCHE
25temporal arteritis10.2
26vertebrobasilar insufficiency10.2
27brain ischemia10.2
28hydrocephalus10.2
29normal pressure hydrocephalus10.2
30parametritis10.2
31capgras syndrome10.2
32hyperlipidemia type 310.2
33blindness10.2
34endotheliitis10.2
35dementia, lewy body10.1BCHE, ACHE, APOE
36diabetes mellitus, noninsulin-dependent10.1ACHE, APOE, BCHE
37stroke, ischemic10.1NOTCH3, APOE
38hypertension, essential10.1AVP, APOE, KLK1
39trichotillomania10.0
40obesity10.0
41carasil syndrome10.0
42osteoarthritis10.0
43paranoid schizophrenia10.0
44arteriolosclerosis10.0
45cerebral artery occlusion10.0
46apraxia10.0
47artery disease10.0
48open-angle glaucoma10.0
49purpura10.0
50autonomic dysfunction10.0

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Symptoms for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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MalaCards organs/tissues related to Vascular Dementia:

31
Brain, Cortex, Testes, Temporal lobe, Heart, Endothelial, Spleen, Cerebellum, Kidney, Parietal lobe, Hypothalamus, Caudate nucleus

Animal Models for Vascular Dementia or affiliated genes

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MGI Mouse Phenotypes related to Vascular Dementia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7NOTCH3, ACHE, CHRM1, APOE
2MP:00053678.5AVP, TNFSF14, APOE, NOTCH3
3MP:00053888.4APOE, CHRM1, ACHE, NOTCH3
4MP:00053978.2NOTCH3, ACHE, CHRM1, APOE, TNFSF14
5MP:00053767.0NOTCH3, AVP, APOE, CHRM1, ACHE, BCHE

Publications for Vascular Dementia

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Articles related to Vascular Dementia:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia. (25703997)
2015
2
Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging: An in vivo MR study. (25862942)
2015
3
Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer's disease. (24175580)
2013
4
The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. (24070657)
2013
5
Trichotillomania in a case of vascular dementia. (23960397)
2013
6
Overestimation of self-reported activities of daily living in vascular dementia patients with a right hemisphere lesion. (21705234)
2013
7
Risk of incident stroke in patients with Alzheimer disease or vascular dementia. (23902701)
2013
8
Plasma viscosity: is a biomarker for the differential diagnosis of Alzheimer's disease and vascular dementia? (23242122)
2013
9
Difficulty with learning of exercise instructions associated with 'working memory' dysfunction and frontal glucose hypometabolism in a patient with very mild subcortical vascular dementia with knee osteoarthritis. (23887984)
2013
10
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
11
Suitability of neuropsychological tests in patients with vascular dementia (VaD). (22694976)
2012
12
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
13
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
14
Gait and equilibrium in subcortical vascular dementia. (21547149)
2011
15
Can Alzheimer's or vascular dementia be prevented with control of vascular risk factors? (21702410)
2011
16
Multichannel linear descriptors analysis for event-related EEG of vascular dementia patients during visual detection task. (21570339)
2011
17
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
18
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. (21419184)
2011
19
Neurobiology of vascular dementia. (21876809)
2011
20
Sleep disturbance and daytime sleepiness predict vascular dementia. (20675705)
2011
21
Genetic associations of autopsy-confirmed vascular dementia subtypes. (21474934)
2011
22
Attention deficits in Alzheimer's disease and vascular dementia. (20145028)
2010
23
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance. (20166891)
2010
24
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
25
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
26
Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. (19222553)
2009
27
Vascular dementia 2007. (19394050)
2009
28
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation. (19550366)
2009
29
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
30
Clinical and therapeutic aspects of vascular dementia. (18631786)
2008
31
Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs. (19337467)
2008
32
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. (18674411)
2008
33
Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project. (17573076)
2007
34
Differential diagnosis of Alzheimer's dementia and vascular dementia. (17544644)
2007
35
Vascular dementia and Alzheimer's disease: a waning dichotomy. (18290307)
2007
36
Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)
2007
37
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
38
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
39
Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)
2006
40
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
41
Links between the pathology of Alzheimer's disease and vascular dementia. (15176482)
2004
42
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. (12876259)
2003
43
Prevention of stroke and vascular dementia]. (12910853)
2003
44
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
45
Vascular dementia]. (11925778)
2002
46
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
47
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
48
Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)
1996
49
Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)
1996
50
Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. (8848934)
1995

Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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Compounds for genes affiliated with Vascular Dementia

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Compounds related to Vascular Dementia according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1ambenonium43 1211.2ACHE, BCHE
2acephate59 4311.2ACHE, BCHE
3choline ester4310.2ACHE, BCHE
4bw 284 c 514310.2ACHE, BCHE
5butyrylthiocholine43 1211.2BCHE, ACHE
6thiocholine4310.2BCHE, ACHE
7fasciculin4310.2BCHE, ACHE
8galanthamine hydrobromide5910.1BCHE, ACHE
9alpha-solanine4310.1ACHE, BCHE
10donepezil hydrochloride5910.1BCHE, ACHE
11pralidoxime43 1211.1ACHE, BCHE
12isomalathion4310.1ACHE, BCHE
13obidoxime4310.1ACHE, BCHE
14rivastigmine tartrate5910.1BCHE, ACHE
15echothiophate43 1211.1ACHE, BCHE
16butyrylcholine4310.1BCHE, ACHE
17benzoylcholine4310.1BCHE, ACHE
18acetylthiocholine4310.1BCHE, ACHE
19o-nitroacetanilide4310.1ACHE, BCHE
20methamidophos4310.1ACHE, BCHE
21edrophonium43 1211.1ACHE, BCHE
22decamethonium43 1211.1ACHE, BCHE
23neostigmine43 1211.1BCHE, ACHE
24carbofuran4310.1BCHE, ACHE
25aldicarb4310.0BCHE, ACHE
26tiapride4310.0BCHE, ACHE
27phenserine43 5911.0ACHE, BCHE
28bambuterol43 1211.0ACHE, BCHE
29fenitrothion4310.0BCHE, ACHE
30chlorpyrifos oxon439.9BCHE, ACHE
31rivastigmine43 1210.8ACHE, BCHE, APOE
32metrifonate439.8APOE, ACHE, BCHE
33tacrine43 1210.8BCHE, ACHE, APOE
34galantamine43 49 1211.8APOE, ACHE, BCHE
35mivacurium43 1210.8BCHE, ACHE
36cyclosarin439.7ACHE, BCHE
37glycopyrrolate43 1210.7BCHE, CHRM1
38tabun439.6BCHE, ACHE
39ethopropazine43 1210.6ACHE, BCHE, CHRM1
40succinylcholine43 49 28 1212.6ACHE, CHRM1, BCHE
41scopolamine43 28 24 1212.6ACHE, CHRM1, BCHE
42gallamine43 2810.5ACHE, CHRM1
43huperzine a439.4BCHE, ACHE
44atropine43 28 1211.3ACHE, CHRM1, BCHE
45donepezil43 49 24 1212.2APOE, CHRM1, BCHE, ACHE
46nicotine43 28 49 1212.2BCHE, ACHE, APOE, CHRM1
47acetylcholine43 49 28 24 1213.0ACHE, BCHE, APOE, CHRM1
48glutamate438.4APOE, CHRM1, ACHE, BCHE, AVP
49arginine438.2CHRM1, BCHE, APOE, AVP, KLK1, NOTCH3
50serine437.9AVP, ACHE, BCHE, GSTO1, KLK1, APOE

GO Terms for genes affiliated with Vascular Dementia

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Cellular components related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304258.6AVP, APOE, CHRM1, ACHE
2extracellular regionGO:00055768.4AVP, APOE, ACHE, BCHE, NOTCH3
3extracellular spaceGO:00056158.1AVP, TNFSF14, APOE, ACHE, BCHE

Biological processes related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1choline metabolic processGO:00196959.4BCHE, ACHE
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.4TNFSF14, AVP
3synaptic transmission, cholinergicGO:00072719.3BCHE, ACHE, APOE

Molecular functions related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholinesterase activityGO:00039909.6BCHE, ACHE
2cholinesterase activityGO:00041049.4BCHE, ACHE
3cysteine-type endopeptidase inhibitor activity involved in apoptotic processGO:00430279.4TNFSF14, AVP
4beta-amyloid bindingGO:00015409.4BCHE, ACHE, APOE

Products for genes affiliated with Vascular Dementia

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Sources for Vascular Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet