Vascular Dementia malady

Disease Ontology: A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.⁶

MalaCards: Vascular Dementia, also known as dementia, vascular, is related to alzheimer's disease and frontotemporal dementia. An important gene associated with Vascular Dementia is FAM134B (family with sequence similarity 134, member B), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Graft-versus-host disease. The drugs citalopram hydrobromide and citalopram and the compounds glucose and nicotine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia: Vascular dementia is dementia caused by problems in supply of blood to the brain. This type of dementia...⁴⁴ more...

Aliases & Descriptions:

vascular dementia 6 8 dementia, vascular 33 43 multi infarct dementia 6 multi-infarct dementia 43

multifocal dementia 6 dementia vascular 32 dementia 43

Diseases related to vascular dementia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 999)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	37.4	APOE, APP, MAPT, PSEN1, PRNP
2	frontotemporal dementia	36.4	BDNF, BCHE, APOA1, APOE, APP, MAPT
3	semantic dementia	32.5	APOE, MAPT, RPS27A
4	tauopathy	32.5	APP, MAPT, RPS27A, PSEN1
5	inclusion body myopathy	32.1	APP, RPS27A, NGF, PSEN1
6	aids dementia complex	32.1	BDNF, IVD, IL1B, MBP, TNF, SOD1
7	cadasil	31.2	MTHFR, APOE, APP, MBP, NOTCH3, RPS27A
8	pick's disease	31.1	BDNF, CHAT, APOE, APP, MBP, MAPT
9	binswanger's disease	31.0	MAPT, GFAP, SYP
10	progressive supranuclear palsy	30.7	CHAT, APOE, APP, MAPT, RPS27A, ACHE
11	immunodeficiency	30.5	BCR, IL6, APOH, MBP, MAPT, TNF
12	primary progressive aphasia	30.3	APP, MAPT, PRNP
13	aphasia	30.1	APOE, APP, MAPT, CBS, RPS27A, PRNP
14	motor neuron disease	29.6	VEGFA, BDNF, CHAT, APOE, MAPT, IGF1
15	cerebral atrophy	29.4	APOE, MAPT, RPS27A, GFAP
16	paget's disease of bone	29.4	IL1B, IL6, ESR1, TNF, TNFRSF11B, RPS27A
17	lewy body dementia	29.2	BCHE, APOE, APP, MAPT, RPS27A, ACHE
18	supranuclear palsy	29.1	VEGFA, BCHE, CHAT, CHRM1, APOE, APOH
19	creutzfeldt-jakob syndrome	28.9	SERPINA3, APOE, APP, MAPT, RPS27A, PRNP
20	normal pressure hydrocephalus	28.9	BDNF, APOE, MAPT, ACE, GFAP, TGFB1
21	alcoholism	28.6	LBR, MAPT, HTR1A, CRH, NGF, NPY
22	familial idiopathic basal ganglia calcification	28.6	APP, MAPT, PSEN1
23	early-onset familial alzheimer disease	28.6	APP, MAPT, PSEN1
24	basal ganglia calcification	28.6	APP, MAPT, PSEN1
25	alzheimer disease type 2	28.5	APOB, APOE, PSEN1
26	gliosis	28.4	CHAT, IL1A, IL6, APP, MBP, MAPT
27	prion disease	28.4	APP, MAPT, PSEN1, PRNP, CST3
28	memory impairment	28.3	PDE4A, BDNF, BCHE, CHAT, APOE, APP
29	chorea	28.1	BDNF, CBS, RPS27A, ACHE, GFAP, TGM2
30	acquired immunodeficiency syndrome	27.9	SDHB, LBR, CETP, MBP, MAPT, CTSD
31	paraplegia	27.4	MTHFR, IL6, MBP, ACE, GFAP, PSEN1
32	myocardial infarction	27.2	APOB, APOE, ESR1, ACE
33	cognitive disease	27.2	CHRM1, APOE, APP, MAPT, HTR1A, ACHE
34	spasticity	27.0	VEGFA, BCR, MTHFR, MMP9, MBP, MAPT
35	hereditary diffuse leukoencephalopathy with spheroids	26.9	LPA, CETP, APOA1, APOB
36	xanthomatosis	26.8	LPA, APOA1, APOB, APOE
37	myoclonus	26.8	SDHB, HTR1A, COX5A, GFAP, PSEN1
38	head injury	26.8	SELP, BDNF, CHAT, CHRM1, IL1A, IL1B
39	huntington's disease	26.8	SERPINA3, BDNF, SDHB, CHAT, APP, MAPT
40	multiple system atrophy	26.6	SERPINA3, BDNF, CHAT, IL1A, IL1B, IL6
41	insomnia	26.5	HTR1A, CAT, CRH, PRNP, SLC6A4
42	mood disorder	26.5	PDE4A, BDNF, HTR1A, CRH, NPY, SLC6A4
43	amyotrophic lateral sclerosis	26.4	SERPINE1, VEGFA, LPA, BDNF, CHAT, MTHFR
44	lateral sclerosis	26.3	SERPINE1, VEGFA, LPA, BDNF, CHAT, MTHFR
45	cerebral amyloid angiopathy	26.3	SERPINA3, BCHE, MMP9, IL1A, IL6, APOE
46	hereditary cerebral hemorrhage with amyloidosis	26.3	IL6, APP, CTSD, RPS27A, GFAP, SYP
47	parkinson's disease	26.1	SERPINA3, BDNF, BCHE, CHAT, GSTO1, APOE
48	multiple sclerosis	26.0	IL1A, IL1B, APOE, MBP, ICAM1
49	adrenoleukodystrophy	26.0	PDE4A, IL1B, IL6, MBP, CBS, CAT
50	myopathy	26.0	BDNF, SDHB, CHAT, MMP9, IL1A, IL1B

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 citalopram, citalopram hydrobromide, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate, risperidone

MalaCards organs/tissues related to vascular dementia:

²²

MGI Mouse Phenotypes related to vascular dementia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	PSEN1, TSC22D3
2	hematopoietic system phenotype	MP:0005397	10.6	CCNA2, TNFSF14, NOTCH3, TGM2
3	respiratory system phenotype	MP:0005388	9.8	ADAMTS2, PSEN1, ACHE, NOTCH3, CRH, CBS
4	craniofacial phenotype	MP:0005382	9.8	ECE1, PSEN1, ACHE, TNFRSF19, CBS, MIXL1
5	other phenotype	MP:0005395	9.4	PRNP, PSEN1, CRH, ESR2, MAPT, APP
6	integument phenotype	MP:0010771	9.2	ADAMTS2, SLC6A4, PSEN1, NGF, CRH, SREBF2
7	hearing/vestibular/ear phenotype	MP:0005377	9.0	TNFRSF11B, NOTCH3, ACHE, SOD1, ECE1, ESR2
8	renal/urinary system phenotype	MP:0005367	8.8	PSEN1, TGM2, AGTR1, AGT, NOTCH3, ESR2
9	liver/biliary system phenotype	MP:0005370	8.7	SOD1, AGT, SREBF2, ESR2, CBS, APOB
10	no phenotypic analysis	MP:0003012	8.3	ACHE, AGER, TGM2, SYP, DCX, PRNP
11	limbs/digits/tail phenotype	MP:0005371	8.1	ESR2, TNFRSF11B, PSEN1, PRNP, OCLN, ESR1
12	normal phenotype	MP:0002873	7.9	AGER, GFAP, SYP, PSEN1, PRNP, NPY
13	skeleton phenotype	MP:0005390	7.9	ESR1, ESR2, TNFRSF11B, ECE1, IGF1, IL6
14	immune system phenotype	MP:0005387	7.8	ECE1, OCLN, PRNP, PSEN1, TGM2, GFAP
15	behavior/neurological phenotype	MP:0005386	7.6	ESR2, SELP, BDNF, BCR, CHAT, CBS
16	reproductive system phenotype	MP:0005389	7.4	NOTCH3, ACHE, AGT, TGFB1, DCX, PRNP
17	nervous system phenotype	MP:0003631	7.2	SLC6A4, NPY, CST3, OCLN, PSEN1, DCX
18	digestive/alimentary phenotype	MP:0005381	7.0	ESR2, CTSD, GFAP, TGFB1, PSEN1, OCLN
19	growth/size phenotype	MP:0005378	6.9	DCX, GFAP, AGTR1, AGT, AGER, ACHE
20	adipose tissue phenotype	MP:0005375	6.8	NPY, TGFB1, AGT, ACHE, ACE, TNF
21	vision/eye phenotype	MP:0005391	6.0	TNF, SREBF2, CTSD, NGF, ACHE, GFAP
22	mortality/aging	MP:0010768	5.4	VEGFA, SERPINE1, SELP, VWF, SLC6A4, PRNP
23	tumorigenesis	MP:0002006	5.3	ESR2, TNF, PLA2G2A, NOTCH3, ACE, TGFB1
24	muscle phenotype	MP:0005369	5.2	PSEN1, TGFB1, GFAP, AGT, AGER, PRNP
25	cellular phenotype	MP:0005384	3.9	CRH, CTSD, TNFSF14, TNFRSF11B, TNF, ESR2
26	homeostasis/metabolism phenotype	MP:0005376	3.2	GFAP, AGT, AGER, ACHE, NOTCH3, CRH
27	cardiovascular system phenotype	MP:0005385	2.9	ECE1, TNFRSF19, TNFRSF11B, TNF, ESR2, ESR1

Articles related to vascular dementia:

(show top 50)    (show all 147)

id	Title	Authors	Year	Affiliating Genes
1	Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)	Ning M.... He L.	2011	MAPT
2	A strong synergistic epistasis between FAM134B and TN FRSF19 on the susceptibility to vascular dementia. (21127458)	Kong M.... Lee C.	2011	TNFRSF19, FAM134B
3	Linkage to 20p13 including the ANGPT4 gene in familie s with mixed Alzheimer's disease and vascular dementia. (20596041)	SillAcn A.... Graff C.	2010	ANGPT4
4	Apolipoprotein epsilon4 and neuropsychological perfor mance in Alzheimer's disease and vascular dementia. (20678545)	McGuinness B.... Passmore A.P.	2010	APOE
5	The MTHFR C677T polymorphism contributes to an increa sed risk for vascular dementia: a meta-analysis. (20441995)	Liu H.... Liu R.W.	2010	MTHFR
6	Estrogen receptor beta gene variant is associated wit h vascular dementia in elderly women. (19473078)	Dresner-Pollak R.... Pollak A.	2009	ESR1, ESR2
7	Increased plasma urotensin-II and carotid atheroscler osis are associated with vascular dementia. (19638714)	Ban Y.... Kobayashi Y.	2009	IL6
8	Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions. (19184337)	Qureischie H.... KAPlsch H.	2009	APOE, CETP
9	Lack of association between PRNP 1368 polymorphism an d Alzheimer's disease or vascular dementia. (19351416)	Jeong B.H.... Kim Y.S.	2009	PRNP
10	Potential therapeutic targets of huperzine A for Alzh eimer's disease and vascular dementia. (18565502)	Zhang H.Y.... Tang X.C.	2008	APP, ACHE
11	Sporadic vascular dementia as clinical presentation of a new missense mutation within exon 7 of NOTCH3 gene. (18499132)	Pradotto L.... Mauro A.	2008	NOTCH3
12	Promoter sequence variants of LIGHT are associated with female vascular dementia. (18320356)	Kong M.... Lee C.	2008	TNFSF14
13	Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)	Romanitan M.O.... Bogdanovic N.	2007	OCLN
14	The factors of oxidative stress in neurodegenerative diseases (vascular dementia, Alzheimer disease) (18383721)	Dubinina E.E.... Konovalov P.V.	2007	SOD1
15	Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)	Gdovinova Z.... Novosadova Z.	2006	APOE
16	Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia. (16465461)	Wang H.K.... Chen C.M.	2006	ACE, VEGFA, APOE
17	Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. (16783499)	Yasutake C.... Yoneda H.	2006	IL1B, BDNF
18	AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosis. (15990115)	Stefani A.... Bernardi G.	2005	MAPT
19	Donepezil in vascular dementia: combined analysis of two large-scale clinical trials. (16192723)	RomA!n G.C.... Schindler R.J.	2005	ACHE
20	Noninfarct vascular dementia and Alzheimer dementia s pectrum. (15760616)	Emery V.O.... Smith J.A.	2005	VEGFA
21	Links between the pathology of Alzheimer's disease an d vascular dementia. (15176482)	Sadowski M.... Wisniewski T.	2004	APP
22	Apolipoprotein E polymorphism in ischemic cerebrovascular diseases and vascular dementia patients in Taiwan. (15084782)	Lin H.F.... Liu C.K.	2004	APOE
23	Rivastigmine in vascular dementia. (15163283)	Moretti R.... Bava A.	2004	BCHE
24	Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. (15623683)	Kolsch H.... Heun R.	2004	GSTO1
25	Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia. (14739533)	Luthra K.... Dey A.B.	2004	APOE
26	NMDA-antagonism (memantine): an alternative pharmacol ogical therapeutic principle in Alzheimer's and vascular dementia. (14754385)	Koch H.J.... Haen E.	2004	ACHE
27	Drugs and vascular dementia. (12714793)	Allain H.... Pinel J.F.	2003	ACHE
28	Acetylcholinesterase inhibitors for vascular dementia and Alzheimer's disease combined with cerebrovascular disease. (12574580)	Bowler J.V.	2003	ACHE
29	Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. (12845379)	Souza D.R.... dos Santos J.E.	2003	APOE
30	Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. (14561434)	SchAPnknecht P.... SchrAPder J.	2003	MAPT
31	Vascular dementia (11925778)	Schmidt R.	2002	ACHE
32	Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)	Erkinjuntti T.... Damaraju C.V.	2002	VEGFA
33	Is ApoE gene a risk factor for vascular dementia in Han Chinese? (11172628)	Yang J.... He L.	2001	APOE
34	The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia. (10855603)	Pollak R.D.... Blumenfeld A.	2000	MTHFR
35	Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. (10940674)	Rodriguez Martin T.... Forloni G.	2000	PSEN1, APOE, SERPINA3
36	Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia. (10938012)	Yoo J.H.... Kang S.S.	2000	CBS, MTHFR
37	Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia. (10471976)	Tarkowski E.... Tarkowski A.	1999	MAPT, IL1B
38	Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease. (9701675)	Ji Y.... Nakashima K.	1998	APOE
39	No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia. (9855368)	Arai H.... Sasaki H.	1998	MAPT
40	Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia. (9455982)	Ihara Y.... Kuroda S.	1997	SOD1
41	Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. (9520135)	Bergem A.L.... Lannfelt L.	1997	APOE
42	Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)	Isoe K.... Nakashima K.	1996	PSEN1
43	Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)	Isoe K.... Takahashi K.	1996	APOE
44	The apolipoprotein E gene in Binswanger's disease and vascular dementia. (9147873)	Higuchi S.... Trojanowski J.Q.	1996	APOE
45	Intact brain serotonin system in vascular dementia. (8835882)	Hansson G.... Marcusson J.	1996	HTR1A
46	Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. (8848934)	StengAYrd J.H.... Nissinen A.	1995	APOE
47	Apolipoprotein E (APOE) allele frequencies in late-onset sporadic Alzheimer's disease (AD), mixed dementia and vascular dementia: lack of association of epsilon 4 allele with AD in Italian octogenarian patients. (8786847)	Scacchi R.... Corbo R.M.	1995	APOE
48	Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls. (8038870)	Zhan S.S.... Schmitt H.P.	1994	SYP
49	Normal sequences of muscarinic acetylcholine receptor s (m1 and m2) in patients with Alzheimer's disease and vascular dementia. (7816331)	Ohara K.... Ohara K.	1994	CHRM1
50	Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls. (8213084)	Zhan S.S.... Schmitt H.P.	1993	SYP

Genes related to vascular dementia according to GeneCards:

(show top 50)    (show all 82)

id	Symbol	Description	Score	GeneCards Section Context
1	FAM134B	family with sequence similarity 134, member B	11.1	Publications, Summaries
2	ACHE	acetylcholinesterase	11.0	Publications
3	MIXL1	Mix paired-like homeobox	11.0
4	MSBP2	minisatellite binding protein 2, 77kDa	11.0	Publications
5	KLK6	kallikrein-related peptidase 6	11.0	Publications
6	GSTO1	glutathione S-transferase omega 1	11.0	Publications
7	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13	11.0
8	KLK1	kallikrein 1	11.0	Publications
9	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	11.0	Publications
10	NOTCH3	notch 3	11.0	Publications
11	APOE	apolipoprotein E	11.0	Publications
12	IVD	isovaleryl-CoA dehydrogenase	11.0
13	CHRM1	cholinergic receptor, muscarinic 1	11.0	Publications
14	OCLN	occludin	11.0	Publications
15	TSC22D3	TSC22 domain family, member 3	11.0	Publications
16	BCHE	butyrylcholinesterase	11.0	Publications
17	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0	Publications
18	ANGPT4	angiopoietin 4	11.0	Publications
19	AVP	arginine vasopressin	11.0	Publications
20	DCX	doublecortin	11.0	Publications
21	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	11.0
22	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	11.0	Publications
23	SREBF2	sterol regulatory element binding transcription factor 2	11.0	Publications
24	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
25	SYP	synaptophysin	11.0	Publications
26	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
27	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
28	MAPT	microtubule-associated protein tau	11.0	Publications
29	LBR	lamin B receptor	11.0	Publications
30	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
31	CHAT	choline O-acetyltransferase	11.0	Publications
32	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
33	ECE1	endothelin converting enzyme 1	11.0	Publications
34	CBS	cystathionine-beta-synthase	11.0	Publications
35	PSEN1	presenilin 1	11.0	Publications
36	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
37	PRNP	prion protein	11.0	Publications
38	LPA	lipoprotein, Lp(a)	11.0	Publications
39	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
40	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
41	RPS27A	ribosomal protein S27a	11.0	Publications
42	NPY	neuropeptide Y	11.0	Publications
43	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
44	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
45	GFAP	glial fibrillary acidic protein	11.0	Publications
46	BCR	breakpoint cluster region	11.0	Publications
47	CTSD	cathepsin D	11.0	Publications
48	CCNA2	cyclin A2	11.0	Publications
49	CST3	cystatin C	11.0	Publications
50	CRH	corticotropin releasing hormone	11.0	Publications

Pathways related to vascular dementia according to GeneDecks:

(show all 42)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.7	AGTR1
2	Graft-versus-host disease20	10.3	IL1A
3	Neuroscience3	9.9	SOD1, PSEN1, DCX, SYP, GFAP, NGF
4	Alzheimers Disease Pathway36	9.9	APOE, APP, MAPT, PSEN1
5	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.8	TGFB1, AGTR1, AGT, ACE
6	Prion diseases20	9.8	SOD1, PRNP, IL6, IL1B, IL1A
7	Endothelin-1 Signaling Pathway36	9.7	ECE1, PLA2G2A, TNFSF14, ANGPT4, IL6, IL1B
8	Metalloproteases in connective tissue degradation10	9.7	CST3, MBP, MMP9, MMP3, MMP1
9	Selected targets of C/EBPbeta10	9.7	MBP, APOB, CETP, VWF
10	Selected targets of HNF110	9.6	APOH, APOB, APOA1, LPA
11	Alzheimers disease20	9.5	PSEN1, COX5A, TNF, MAPT, APP, APOE
12	Immune response_MIF-mediated glucocorticoid regulation41	9.4	TNF, ICAM1, IL6, MMP1
13	Immune response MIF-mediated glucocorticoid regulation10	9.4	TNF, ICAM1, IL6, MMP1
14	MIF Mediated Glucocorticoid Regulation36	9.4	PLA2G2A, TNFSF14, TNF, ANGPT4, IL6, IL1B
15	MIF Regulation of Innate Immune Cells36	9.3	PLA2G2A, TNFSF14, TNF, ANGPT4, IL6, IL1B
16	all-trans-Retinoic Acid Signaling in Brain36	9.3	PLA2G2A, TNFSF14, TNF, ANGPT4, IL6, IL1B
17	Cell adhesion_ECM remodeling41	9.3	KLK1, IGF1, MMP9, MMP3, MMP1, SERPINE1
18	Cell adhesion ECM remodeling10	9.3	KLK1, SERPINE1, MMP1, MMP3, MMP9, IGF1
19	Cytokine Network36	9.3	TNF, IL6, IL1B, IL1A
20	African trypanosomiasis20	9.2	TNF, ICAM1, APOA1, IL6, IL1B
21	PEDF Induced Signaling36	9.2	TNFSF14, TNF, ANGPT4, IL6, IL1B, IL1A
22	IL-10 Pathway36	9.2	TNF, IL6, IL1B, IL1A
23	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	IL1B, IL6, TGFB1
24	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	TNFRSF11B, TNF, IGF1, APOE, IL6, IL1B
25	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	TNFRSF11B, TNF, IGF1, APOE, IL6, IL1B
26	Immune response IL-1 signaling pathway10	8.9	TNF, IL6, IL1B, IL1A, SERPINE1
27	Immune response_IL-1 signaling pathway41	8.9	TNF, IL6, IL1B, IL1A, SERPINE1
28	Rho Family GTPases36	8.9	TGFB1, GFAP, TNFSF14, IGF1, ANGPT4, IL1B
29	DHA Signaling36	8.9	TGFB1, PLA2G2A, IGF1, MAPT, APP, IL6
30	Hypertrophic cardiomyopathy (HCM)20	8.6	TGFB1, ACE, TNF, IGF1, IL6
31	Malaria20	8.6	TGFB1, TNF, ICAM1, IL6, IL1B, SELP
32	MAPK signaling pathway20	8.5	TGFB1, NGF, PLA2G2A, TNF, MAPT, IL1B
33	Pancreatic Adenocarcinoma36	8.5	TGFB1, IGF1, CCNA2, IL6, MMP9, MMP3
34	JAK-STAT Pathway36	8.5	TGFB1, AGTR1, AGT, IGF1, ANGPT4, IL6
35	Chagas disease (American trypanosomiasis)20	8.3	TGFB1, ACE, TNF, IL6, IL1B, SERPINE1
36	Cytokine-cytokine receptor interaction20	8.3	TGFB1, TNFSF14, TNFRSF19, TNFRSF11B, TNF, IL6
37	PAK Pathway36	8.3	TGFB1, TNFSF14, TNF, IGF1, ANGPT4, IL6
38	NF-KappaB (p50-p65) Pathway36	8.3	TGFB1, TNF, IGF1, IL6, IL1B, IL1A
39	NF-KappaB Family Pathway36	8.2	TGFB1, TNF, IGF1, IL6, IL1B, IL1A
40	Antioxidant Action of Vitamin-C36	8.2	TGFB1, PLA2G2A, TNFSF14, TNF, IGF1, ANGPT4
41	ERK Signaling36	8.2	TGFB1, TNFSF14, ESR2, ESR1, ANGPT4, IL6
42	Rheumatoid arthritis20	7.9	VEGFA, TGFB1, TNF, ICAM1, IL6, IL1B

Compounds related to vascular dementia according to GeneDecks:

(show top 50)    (show all 441)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.6	PDE4A, AVP, CCNA2, TGM2
2	nicotine32 34 9 9	13.3	CRH
3	ascorbic acid32 18	10.9	BDNF, SDHB, IL1A, TNFRSF11B, CTSD, PLA2G2A
4	cocaine32 9 9	10.9	PDE4A, SELP, BDNF, BCHE, CHAT, CHRM1
5	nmda32 42	9.9	PDE4A, BDNF, BCHE, SDHB, CHAT, IL1A
6	6-hydroxydopamine32	8.9	BDNF, CHAT, APP, CAT, CTSD, RPS27A
7	histamine32 18	9.8	PDE4A, VWF, SELP, BDNF, LBR, AOC3
8	vitamin b1232	8.8	VWF, SERPINA3, LPA, MTHFR, APOA1, APOB
9	glutamate32	8.7	BCHE, SDHB, CHAT, CHRM1, MTHFR, MMP3
10	pravastatin32 34 9 18 9	12.6	SELP, SERPINE1, LPA, BCHE, CETP, IL6
11	n acetylcysteine32	8.5	VWF, SELP, BDNF, MMP1, MMP3, MMP9
12	uric acid32 18	9.2	SERPINE1, LPA, MTHFR, AVP, APOA1, APOB
13	fibrinogen32	8.2	SELP, SERPINE1, SERPINA3, LPA, IL6, APOA1
14	choline32 9 18 9	11.2	BCHE, CHAT, CHRM1, MTHFR, APOA1, APOB
15	dopamine32 9 18 9	11.2	PDE4A, SERPINA3, BDNF, SDHB, CHAT, CHRM1
16	homocysteine32 18	9.1	VWF, SELP, SERPINE1, LPA, CETP, APOA1
17	calcium32 9 18 9	10.9	PDE4A, VWF, SERPINA3, LPA, BDNF, BCHE
18	fluvastatin32 34 9 9	10.8	VWF, SELP, SERPINE1, CETP, MMP1, MMP9
19	alpha tocopherol32	7.8	MTHFR, CETP, MMP1, MMP9, APOA1, APOB
20	superoxide32 18	8.8	PDE4A, SERPINA3, LPA, SDHB, LBR, IL1B
21	cysteine32	7.8	SELP, SERPINA3, LPA, SDHB, LBR, MTHFR
22	h2o232	7.7	PDE4A, VWF, LPA, BDNF, BCHE, BCR
23	nifedipine32 9 9	9.7	SERPINE1, BDNF, CHAT, LBR, MMP9, IL1A
24	testosterone32 9 18 9	10.6	BDNF, SDHB, CHAT, LBR, MTHFR, CETP
25	tamoxifen32 34 9 9	10.5	PDE4A, VEGFA, BDNF, CETP, APOA1, APOB
26	acetylcholine32 9 18 9	10.5	PDE4A, VWF, SERPINA3, BDNF, BCHE, CHAT
27	ly29400232	7.5	VEGFA, BCR, MMP9, IL1B, IL6, CCNA2
28	sb 20358032 42	8.4	VEGFA, MMP1, MMP3, MMP9, IL6, CCNA2
29	epinephrine32 9 18 9	10.4	PDE4A, SELP, BDNF, SDHB, LBR, MMP1
30	alanine32	7.3	VWF, BCHE, CHAT, CHRM1, AVP, CETP
31	glutamine32	7.2	PDE4A, VWF, CETP, MMP3, IL1A, APOB
32	atorvastatin32 34 9 18 9	11.1	VWF, SELP, VEGFA, LPA, CETP, MMP1
33	adenylate32	7.0	PDE4A, VWF, SELP, SERPINE1, BDNF, CHRM1
34	paraffin32	6.6	VWF, SERPINA3, VEGFA, CHAT, MMP1, MMP3
35	norepinephrine32 9 18 9	9.6	PDE4A, VWF, SELP, BDNF, BCHE, SDHB
36	aspirin32 34 18	8.3	PDE4A, VWF, SELP, SERPINE1, LPA, BCHE
37	cholesterol32 9 18 9	9.1	VWF, SELP, SERPINE1, SERPINA3, LPA, BDNF
38	simvastatin32 34 42 9 18 9	11.1	VWF, SELP, SERPINE1, VEGFA, LPA, BCHE
39	pd 98,05932	6.0	PDE4A, SERPINE1, BDNF, BCR, CHAT, MMP1
40	prostacyclin32	6.0	PDE4A, VWF, SELP, SERPINE1, VEGFA, IL1A
41	indomethacin32 9 9	7.8	PDE4A, BDNF, MMP1, MMP3, IL1A, IL1B
42	methotrexate32 34 42 9 9	9.7	SERPINE1, SERPINA3, MTHFR, MMP1, MMP3, MMP9
43	estrogen32	5.7	VWF, SERPINE1, SERPINA3, LPA, BDNF, CHAT
44	lipid32	5.3	PDE4A, SERPINE1, SERPINA3, LPA, BDNF, BCR
45	creatinine32	5.2	VWF, SELP, SERPINA3, BDNF, BCHE, SDHB
46	lactate32	5.1	VWF, SELP, BDNF, BCHE, SDHB, CHAT
47	actinomycin d32	4.0	PDE4A, SERPINE1, VEGFA, LPA, BDNF, MMP9
48	genistein32 9 18 9	6.9	SELP, SERPINE1, VEGFA, BCR, CHRM1, LBR
49	retinoic acid32 42 18	5.2	PDE4A, VWF, SELP, SERPINE1, SERPINA3, BDNF
50	vegf32	2.2	PDE4A, VWF, SELP, SERPINE1, VEGFA, LPA

Cellular components related to vascular dementia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	9.9	APOH, APOE, APOA1, CETP
2	chylomicron	GO:042627	9.9	APOB, APOE, APOH
3	very-low-density lipoprotein particle	GO:034361	9.7	APOH, APOE, APOB, APOA1
4	secretory granule	GO:030141	9.2	PLA2G2A, APOA1, IL1B, AVP, VEGFA
5	platelet alpha granule lumen	GO:031093	8.4	TGFB1, IGF1, APP, VEGFA, SERPINE1, VWF
6	proteinaceous extracellular matrix	GO:005578	8.3	ADAMTS2, TGFB1, TNFRSF11B, MMP9, MMP3, MMP1
7	plasma membrane	GO:005886	5.6	NOTCH3, RPS27A, ACE, ACHE, AGER, AGTR1
8	extracellular space	GO:005615	4.0	NPY, APOE, APOB, APOA1, IL6, IL1B
9	extracellular region	GO:005576	3.8	ADAMTS2, NPY, NPPB, VWF, APOA1, IL6

Biological processes related to vascular dementia according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of renal sodium excretion	GO:035813	10.5	AVP, AGT, AGTR1
2	positive regulation of cholesterol esterification	GO:010873	10.4	AGTR1, AGT, APOE, APOA1
3	regulation of vasoconstriction	GO:019229	10.4	ECE1, AGTR1, AGT, ACE
4	regulation of vasodilation	GO:042312	10.3	ACE, AGTR1, NPPB
5	blood vessel remodeling	GO:001974	10.2	TGM2, AGT, ACE, CBS, IGF1
6	triglyceride metabolic process	GO:006641	10.2	CETP, APOE, APOH, CAT
7	response to copper ion	GO:046688	10.1	IL1A, ICAM1, PRNP, SOD1
8	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.1	AGTR1, AGT, PLA2G2A, APOB
9	lipoprotein metabolic process	GO:042157	10.1	APOE, APOB, APOA1, CETP, LPA
10	low-density lipoprotein particle remodeling	GO:034374	10.1	AGTR1, AGT, PLA2G2A, APOB, CETP
11	memory	GO:007613	10.0	SLC6A4, PSEN1, NGF, IL1B, CHAT
12	collagen catabolic process	GO:030574	10.0	ADAMTS2, KLK6, MMP9, MMP3, MMP1
13	neuron projection development	GO:031175	10.0	NPY, AGER, NGF, APP, IL6
14	response to reactive oxygen species	GO:000302	10.0	SERPINE1
15	positive regulation of inflammatory response	GO:050729	9.9	TGM2, AGTR1, AGT, PLA2G2A, SERPINE1
16	cholesterol transport	GO:030301	9.9	APOB, APOA1, CETP
17	negative regulation of neuron apoptotic process	GO:043524	9.8	SOD1, PSEN1, AGT, NGF, BDNF
18	cholesterol metabolic process	GO:008203	9.8	SREBF2, CAT, APOE, APOB, APOA1, CETP
19	response to wounding	GO:009611	9.8	TGFB1, GFAP, AGER, ACHE, KLK6, VWF
20	negative regulation of blood coagulation	GO:030195	9.8	SERPINE1, APOE, APOH
21	response to ethanol	GO:045471	9.7	AVP, MMP9, ICAM1, SOD1, CHAT
22	positive regulation of cellular protein metabolic process	GO:032270	9.7	TGFB1, AGTR1, AGT
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	TGM2, NOTCH3, TNF, IGF1, IL6
24	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	AGT, IGF1, ANGPT4, IL6, VEGFA
25	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	AGT, CAT, IGF1, SELP
26	positive regulation of mitosis	GO:045840	9.5	TNF, IGF1, IL1B, IL1A
27	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.4	TGM2, RPS27A, TNFRSF19, TNF, IL1B, IL1A
28	proteolysis	GO:006508	9.4	ADAMTS2, ECE1, ACE, KLK6, KLK1, CTSD
29	positive regulation of interleukin-6 production	GO:032755	9.4	TNF, IL6, IL1B, IL1A
30	induction of apoptosis	GO:006917	9.4	TGM2, TGFB1, AGT, TNFSF14, TNFRSF19, TNF
31	lipid metabolic process	GO:006629	9.3	SREBF2, APOE, APOB, APOA1, CETP, LPA
32	positive regulation of MAP kinase activity	GO:043406	9.1	PSEN1, TGFB1, TNF, VEGFA
33	positive regulation of cell division	GO:051781	9.0	TGFB1, CAT, IL1B, IL1A, VEGFA
34	extracellular matrix organization	GO:030198	9.0	ADAMTS2, GFAP, AGT, TNFRSF11B, TNF, APP
35	small molecule metabolic process	GO:044281	9.0	APOE, CBS, CAT, PLA2G2A, COX5A, ACHE
36	positive regulation of angiogenesis	GO:045766	9.0	ANGPT4, IL1B, IL1A, MMP9, VEGFA, SERPINE1
37	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.9	TGFB1, TNF, IL6, AVP, VEGFA
38	response to glucocorticoid stimulus	GO:051384	8.9	NGF, TNF, IL6, IL1B, BCHE, SERPINE1
39	positive regulation of nitric oxide biosynthetic process	GO:045429	8.8	TNF, ESR1, ICAM1, IL1B
40	anti-apoptosis	GO:006916	8.7	BDNF, SOD1, PRNP, PSEN1, TSC22D3, NGF
41	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.4	NGF, TNF, ESR2, ESR1, IL6, IL1B
42	response to estradiol stimulus	GO:032355	8.3	SLC6A4, TGFB1, ESR1, IL1B, MMP9
43	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.2	TGFB1, AGT, AGER, RPS27A, TNF, CAT
44	platelet degranulation	GO:002576	8.2	SOD1, TGFB1, IGF1, APP, APOA1, VEGFA
45	inflammatory response	GO:006954	8.0	CRH, NGF, AGER, TGFB1, NPPB, TNF
46	platelet activation	GO:030168	7.9	SOD1, TGFB1, IGF1, APP, APOA1, IL6
47	response to drug	GO:042493	7.8	NGF, TGFB1, SOD1, NPPB, SLC6A4, TNFRSF11B
48	response to hypoxia	GO:001666	7.6	ECE1, SLC6A4, NPPB, TGFB1, TNF, CAT
49	blood coagulation	GO:007596	7.5	SOD1, TGFB1, IGF1, ANGPT4, APP, APOB
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.6	TGFB1, RPS27A, SREBF2, TNF, ESR1, IGF1

Molecular functions related to vascular dementia according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	beta-amyloid binding	GO:001540	10.3	CST3, ACHE, APOE, APOA1, BCHE
2	cholesterol transporter activity	GO:017127	9.8	CETP, APOA1, APOB
3	heparin binding	GO:008201	9.2	APP, APOH, APOE, APOB, LPA, VEGFA
4	protease binding	GO:002020	9.2	CST3, TNF, MBP, SERPINE1
5	receptor binding	GO:005102	8.7	NPY, NPPB, CRH, TNFSF14, CAT, APP
6	cytokine activity	GO:005125	8.6	TNFSF14, TNFRSF11B, TNF, IL6, IL1B, IL1A
7	protein homodimerization activity	GO:042803	8.3	ECE1, SLC6A4, SOD1, TGFB1, ACHE, CAT
8	growth factor activity	GO:008083	8.2	TGFB1, AGT, NGF, IGF1, IL6, IL1B
9	enzyme binding	GO:019899	7.9	TGFB1, NOTCH3, ESR2, ESR1, CAT, CBS
10	protein binding	GO:005515	3.1	SLC6A4, KLK6, COLQ, NOTCH3, CRH, SREBF2