MCID: VSC002
MIFTS: 48

Vascular Dementia malady

Mental diseases, Cardiovascular diseases categories

Aliases & Classifications for Vascular Dementia

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 33MeSH, 25ICD10
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Aliases & Descriptions for Vascular Dementia:

Name: Vascular Dementia 8 10
Multi Infarct Dementia 8
Multi-Infarct Dementia 61
 
Multifocal Dementia 8
Dementia, Vascular 61
Dementia Vascular 44


Classifications:



External Ids:

Disease Ontology8 DOID:8725
NCIt39 C34522
MeSH33 D015161
ICD1025 F01

Summaries for Vascular Dementia

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Disease Ontology:8 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards based summary: Vascular Dementia, also known as multi infarct dementia, is related to dementia and cerebrovascular disease. An important gene associated with Vascular Dementia is FAM134B (family with sequence similarity 134, member B). The compounds thiocholine and obidoxime have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Wikipedia:64 Vascular dementia, also known as multi-infarct dementia (MID) and vascular cognitive impairment (VCI),... more...

Related Diseases for Vascular Dementia

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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.6BCHE, CHRM1, NOTCH3, APOE, ACHE
2cerebrovascular disease31.0APOE, NOTCH3, ACHE
3hyperhomocysteinemia30.6BCHE, APOE
4binswanger's disease30.6APOE, ACHE, NOTCH3
5dementia, frontotemporal30.4APOE, ACHE
6brain disease30.1BCHE, NOTCH3
7alzheimer disease30.1CHRM1, NOTCH3, GSTO1, APOE, BCHE, ACHE
8schizophrenia29.9CHRM1, BCHE, ACHE
9cerebritis10.8
10cadasil10.5
11abdominal aortic aneurysm10.4APOE
12neuronitis10.4
13cerebral amyloid angiopathy10.4
14supranuclear palsy, progressive10.3ACHE, APOE
15anencephaly10.3BCHE, ACHE
16pick disease10.3ACHE, APOE
17alzheimer disease-210.3APOE, BCHE
18hirschsprung disease 110.2ACHE, BCHE
19atherosclerosis10.2
20ischemia10.2
21pneumonia10.2
22vascular disease10.2
23neural tube defects10.2BCHE, ACHE
24myasthenia gravis10.2ACHE, BCHE
25temporal arteritis10.2
26vertebrobasilar insufficiency10.2
27brain ischemia10.2
28hydrocephalus10.2
29normal pressure hydrocephalus10.2
30parametritis10.2
31capgras syndrome10.2
32hyperlipidemia type 310.2
33blindness10.2
34endotheliitis10.2
35dementia, lewy body10.1BCHE, ACHE, APOE
36diabetes mellitus, noninsulin-dependent10.1ACHE, APOE, BCHE
37stroke, ischemic10.1NOTCH3, APOE
38hypertension, essential10.1AVP, APOE, KLK1
39trichotillomania10.0
40obesity10.0
41carasil syndrome10.0
42osteoarthritis10.0
43paranoid schizophrenia10.0
44arteriolosclerosis10.0
45cerebral artery occlusion10.0
46apraxia10.0
47artery disease10.0
48open-angle glaucoma10.0
49purpura10.0
50autonomic dysfunction10.0

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Symptoms for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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MalaCards organs/tissues related to Vascular Dementia:

31
Brain, Cortex, Testes, Temporal lobe, Heart, Endothelial, Spleen, Cerebellum, Kidney, Parietal lobe, Hypothalamus, Caudate nucleus

Animal Models for Vascular Dementia or affiliated genes

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MGI Mouse Phenotypes related to Vascular Dementia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7NOTCH3, ACHE, CHRM1, APOE
2MP:00053678.5AVP, TNFSF14, APOE, NOTCH3
3MP:00053888.4APOE, CHRM1, ACHE, NOTCH3
4MP:00053978.2NOTCH3, ACHE, CHRM1, APOE, TNFSF14
5MP:00053767.0NOTCH3, AVP, APOE, CHRM1, ACHE, BCHE

Publications for Vascular Dementia

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Articles related to Vascular Dementia:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia. (25703997)
2015
2
Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging: An in vivo MR study. (25862942)
2015
3
Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer's disease. (24175580)
2013
4
The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. (24070657)
2013
5
Trichotillomania in a case of vascular dementia. (23960397)
2013
6
Overestimation of self-reported activities of daily living in vascular dementia patients with a right hemisphere lesion. (21705234)
2013
7
Risk of incident stroke in patients with Alzheimer disease or vascular dementia. (23902701)
2013
8
Plasma viscosity: is a biomarker for the differential diagnosis of Alzheimer's disease and vascular dementia? (23242122)
2013
9
Difficulty with learning of exercise instructions associated with 'working memory' dysfunction and frontal glucose hypometabolism in a patient with very mild subcortical vascular dementia with knee osteoarthritis. (23887984)
2013
10
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
11
Suitability of neuropsychological tests in patients with vascular dementia (VaD). (22694976)
2012
12
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
13
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
14
Gait and equilibrium in subcortical vascular dementia. (21547149)
2011
15
Can Alzheimer's or vascular dementia be prevented with control of vascular risk factors? (21702410)
2011
16
Multichannel linear descriptors analysis for event-related EEG of vascular dementia patients during visual detection task. (21570339)
2011
17
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
18
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. (21419184)
2011
19
Neurobiology of vascular dementia. (21876809)
2011
20
Sleep disturbance and daytime sleepiness predict vascular dementia. (20675705)
2011
21
Genetic associations of autopsy-confirmed vascular dementia subtypes. (21474934)
2011
22
Attention deficits in Alzheimer's disease and vascular dementia. (20145028)
2010
23
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance. (20166891)
2010
24
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
25
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
26
Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. (19222553)
2009
27
Vascular dementia 2007. (19394050)
2009
28
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation. (19550366)
2009
29
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
30
Clinical and therapeutic aspects of vascular dementia. (18631786)
2008
31
Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs. (19337467)
2008
32
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. (18674411)
2008
33
Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project. (17573076)
2007
34
Differential diagnosis of Alzheimer's dementia and vascular dementia. (17544644)
2007
35
Vascular dementia and Alzheimer's disease: a waning dichotomy. (18290307)
2007
36
Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)
2007
37
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
38
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
39
Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)
2006
40
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
41
Links between the pathology of Alzheimer's disease and vascular dementia. (15176482)
2004
42
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. (12876259)
2003
43
Prevention of stroke and vascular dementia]. (12910853)
2003
44
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
45
Vascular dementia]. (11925778)
2002
46
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
47
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
48
Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)
1996
49
Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)
1996
50
Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. (8848934)
1995

Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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Compounds for genes affiliated with Vascular Dementia

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Compounds related to Vascular Dementia according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1thiocholine4410.2BCHE, ACHE
2obidoxime4410.2BCHE, ACHE
3butyrylcholine4410.2BCHE, ACHE
4echothiophate44 1111.2ACHE, BCHE
5rivastigmine tartrate6010.2ACHE, BCHE
6choline ester4410.2ACHE, BCHE
7bw 284 c 514410.2ACHE, BCHE
8isomalathion4410.1BCHE, ACHE
9ambenonium44 1111.1BCHE, ACHE
10acephate60 4411.1ACHE, BCHE
11donepezil hydrochloride6010.1ACHE, BCHE
12galanthamine hydrobromide6010.1ACHE, BCHE
13fasciculin4410.1BCHE, ACHE
14alpha-solanine4410.1ACHE, BCHE
15pralidoxime44 1111.1ACHE, BCHE
16acetylthiocholine4410.1BCHE, ACHE
17benzoylcholine4410.1BCHE, ACHE
18butyrylthiocholine44 1111.1BCHE, ACHE
19o-nitroacetanilide4410.1BCHE, ACHE
20methamidophos4410.1BCHE, ACHE
21tiapride4410.1ACHE, BCHE
22decamethonium44 1111.1BCHE, ACHE
23aldicarb4410.1ACHE, BCHE
24neostigmine44 1111.1BCHE, ACHE
25carbofuran4410.0BCHE, ACHE
26edrophonium44 1111.0ACHE, BCHE
27phenserine44 6011.0ACHE, BCHE
28bambuterol44 1111.0ACHE, BCHE
29fenitrothion4410.0ACHE, BCHE
30mivacurium44 1110.9ACHE, BCHE
31rivastigmine44 1110.9APOE, BCHE, ACHE
32metrifonate449.8BCHE, ACHE, APOE
33tacrine44 1110.8BCHE, APOE, ACHE
34galantamine44 50 1111.8BCHE, ACHE, APOE
35chlorpyrifos oxon449.8BCHE, ACHE
36mipafox449.7BCHE, ACHE
37cyclosarin449.7BCHE, ACHE
38glycopyrrolate44 1110.7CHRM1, BCHE
39huperzine a449.6ACHE, BCHE
40ethopropazine44 1110.6CHRM1, BCHE, ACHE
41succinylcholine44 50 28 1112.6CHRM1, BCHE, ACHE
42scopolamine44 28 24 1112.6ACHE, BCHE, CHRM1
43atropine44 28 1111.3CHRM1, ACHE, BCHE
44gallamine44 2810.2ACHE, CHRM1
45donepezil44 50 24 1112.2ACHE, APOE, CHRM1, BCHE
46nicotine44 28 50 1112.2ACHE, CHRM1, APOE, BCHE
47acetylcholine44 50 28 24 1113.0BCHE, ACHE, CHRM1, APOE
48glutamate448.4CHRM1, ACHE, AVP, APOE, BCHE
49arginine448.2NOTCH3, BCHE, AVP, KLK1, CHRM1, APOE
50serine447.9APOE, BCHE, ACHE, AVP, KLK1, GSTO1

GO Terms for genes affiliated with Vascular Dementia

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Cellular components related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304258.6ACHE, CHRM1, APOE, AVP
2extracellular regionGO:00055768.4NOTCH3, BCHE, ACHE, APOE, AVP
3extracellular spaceGO:00056158.1AVP, TNFSF14, APOE, ACHE, BCHE

Biological processes related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1choline metabolic processGO:00196959.4BCHE, ACHE
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.4TNFSF14, AVP
3synaptic transmission, cholinergicGO:00072719.3BCHE, ACHE, APOE

Molecular functions related to Vascular Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholinesterase activityGO:00039909.6BCHE, ACHE
2cholinesterase activityGO:00041049.4BCHE, ACHE
3cysteine-type endopeptidase inhibitor activity involved in apoptotic processGO:00430279.4TNFSF14, AVP
4beta-amyloid bindingGO:00015409.4BCHE, ACHE, APOE

Sources for Vascular Dementia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet