MCID: VSC002
MIFTS: 57

Vascular Dementia malady

Neuronal diseases, Cardiovascular diseases categories

Summaries for Vascular Dementia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards: Vascular Dementia, also known as dementia, vascular, is related to dementia and vascular disease. An important gene associated with Vascular Dementia is TNF (tumor necrosis factor), and among its related pathways is MSP-RON Signaling. The compounds rivastigmine and metrifonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Vascular dementia or \"multi-infarct dementia\" is dementia caused by problems in the supply of blood to... more...

Aliases & Classifications for Vascular Dementia

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Cardiovascular diseases


Aliases & Descriptions:

vascular dementia 8 10
dementia, vascular 46 60
multi infarct dementia 8
multi-infarct dementia 60
multifocal dementia 8
dementia vascular 44


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Disease Ontology8 DOID:8725
MeSH34 D015161
NCIt39 C34522
ICD1025 F01

Related Diseases for Vascular Dementia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.0BCHE, APOE, CHRM1, NOTCH3, ACHE
2vascular disease31.7BCHE, TNF
3alzheimer's disease31.6KLK6, APOE, AOC3, NEFL, CHRM1, NOTCH3
4cerebrovascular disease30.8APOE, NOTCH3, ACHE
5cadasil30.7APOE, AOC3, AVP, NOTCH3
6hypertension30.6AVP, APOE, KLK1
7cerebral amyloid angiopathy30.4APOE, AOC3
8stroke, ischemic30.4NOTCH3, AOC3
9diabetes mellitus30.4TNF, APOE, AOC3, BCHE
10lewy body dementia30.3APOE
11parkinson's disease30.1APOE
12binswanger's disease30.1ACHE, NOTCH3, APOE
13frontotemporal dementia30.1ACHE, APOE
14schizophrenia29.9NEFL, CHRM1, ACHE, BCHE
15type 2 diabetes mellitus29.9BCHE, ACHE, AOC3, APOE
16obesity29.9TNF, APOE, AOC3, SREBF2, BCHE
17cerebritis10.7
18neuronitis10.3
19brain disease10.3
20vascular cancer10.3
21hyperhomocysteinemia10.2
22atherosclerosis10.2
23vertebrobasilar insufficiency10.2
24temporal arteritis10.2
25peripheral vascular disease10.1
26capgras syndrome10.1
27parametritis10.1
28normal pressure hydrocephalus10.1
29cerebral arterial disease10.1
30hydrocephalus10.1
31ischemia10.1
32pneumonia10.1
33hyperlipidemia type 310.1
34ovarian cancer10.0KLK6, KLK1
35neuropathy10.0NEFL
36breast cancer10.0KLK6, TNFSF14, ANGPT4, BCHE
37progressive supranuclear palsy10.0ACHE, NEFL, APOE
38prion disease10.0BCHE, AVP
39amyotrophic lateral sclerosis10.0NEFL
40memory impairment10.0BCHE, ACHE, APOE
41prostate cancer10.0KLK6, AOC3, CHRM1, SREBF2
42hypertriglyceridemia10.0APOE, BCHE
43myopathy10.0NEFL, NOTCH3, ACHE
44myasthenia gravis10.0ACHE, BCHE
45abdominal aortic aneurysm10.0APOE
46diabetic retinopathy10.0AOC3, OCLN
47familial hyperlipidemia10.0APOE, ACHE, SREBF2
48pick's disease10.0ACHE, APOE
49hypothyroidism10.0AVP
50colon cancer10.0ACHE, TNFSF14

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Clinical Features for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Dementia

Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Search CenterWatch for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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32MalaCards
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MalaCards organs/tissues related to Vascular Dementia:

32
Brain, Testes, Cortex, Temporal lobe, Heart, Endothelial, Hypothalamus, Parietal lobe, Spleen, Kidney, Cerebellum, Caudate nucleus

Animal Models for Vascular Dementia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Vascular Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3GSTO1, APOE, OCLN, CHRM1, AVP, NOTCH3

Publications for Vascular Dementia

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50PubMed
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Articles related to Vascular Dementia:

(show top 50)    (show all 648)
idTitleAuthorsYear
1
Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD). (24238885)
2014
2
The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. (24070657)
2013
3
Effects of acupuncture on Chinese medicine syndromes of vascular dementia. (24155069)
2013
4
Epidemiology, co-morbidities, and medication use of patients with Alzheimer's disease or vascular dementia in the UK. (23455986)
2013
5
Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia. (23627757)
2013
6
A Promising Method to Distinguish Vascular Dementia From Alzheimer's disease with Standardized Low-Resolution Brain Electromagnetic Tomography and Quantitative EEG. (24214287)
2013
7
Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia. (22890100)
2013
8
Cognitive deficits of pure subcortical vascular dementia vs. Alzheimer disease: PiB-PET-based study. (23325910)
2013
9
Cerebrospinal Fluid I8 Protein in Differential Diagnosis of Alzheimer's Disease and Vascular Dementia in Chinese population: A Meta-Analysis. (24164930)
2013
10
Cortical thinning in subcortical vascular dementia with negative 11C-PiB PET. (22531413)
2012
11
Genetic association of the gene encoding RPGRIP1L with susceptibility to vascular dementia. (22425971)
2012
12
Lack of common genetic factors for susceptibility to vascular dementia and Alzheimer's disease. (22326524)
2012
13
Pharmacological prevention and treatment of vascular dementia: approaches and perspectives. (22796225)
2012
14
Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. (22526544)
2012
15
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
16
Genetic associations of autopsy-confirmed vascular dementia subtypes. (21474934)
2011
17
A voxel-based morphometric analysis of cerebral gray matter in subcortical ischemic vascular dementia patients and normal aged controls. (21850200)
2011
18
Genetic dissection of susceptibility to vascular dementia. (21116211)
2011
19
Hypertension is a potential risk factor for vascular dementia: systematic review. (21495075)
2011
20
Subcortical vascular dementia. (21821070)
2011
21
Comparison of vascular stiffness in vascular dementia, Alzheimer dementia and cognitive impairment. (21623679)
2011
22
Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study. (20626720)
2010
23
Cancer linked to Alzheimer disease but not vascular dementia. (20032288)
2010
24
Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. (19222553)
2009
25
CSF biomarker profile and diagnostic value in vascular dementia. (19146641)
2009
26
Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia. (20209467)
2009
27
B-type natriuretic peptide plasma levels are elevated in subcortical vascular dementia. (19424098)
2009
28
Excessive compensatory recruitment as a compulsory neurophysiological mechanism in Very Early Alzheimer's Disease as compared to Mild Vascular Dementia and to age-matched normal controls. (19414051)
2009
29
Inappropriate sexual behaviors in patients with vascular dementia: possible response to finasteride. (20121967)
2009
30
The role of the -427T/C apolipoprotein E promoter polymorphism in the pathogenesis of Alzheimer's disease, vascular dementia and mixed dementia. (19142571)
2009
31
Cardiovascular risk factors in vascular dementia and ischaemic stroke. (18560245)
2008
32
Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia. (18405055)
2008
33
Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)
2007
34
Cerebrovascular reactivity in degenerative and vascular dementia: a transcranial Doppler study. (17565221)
2007
35
Rivastigmine in Chinese patients with subcortical vascular dementia. (19300631)
2007
36
Yizhi capsule for vascular dementia. (17443586)
2007
37
Pathological alterations of the climbing fibres of the cerebellum in vascular dementia: a Golgi and electron microscope study. (17448497)
2007
38
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
39
Pattern of vascular dementia in India: study of clinical features, imaging, and vascular mechanisms from a hospital dementia registry. (17904048)
2006
40
Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia. (16555084)
2006
41
NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia. (14754385)
2004
42
Apolipoprotein E polymorphism in ischemic cerebrovascular diseases and vascular dementia patients in Taiwan. (15084782)
2004
43
Phenotypic profiles and functional genomics in Alzheimer's disease and in dementia with a vascular component. (15265264)
2004
44
APOE genotype in cerebrovascular disease and vascular dementia. (12417379)
2002
45
Acetazolamide vasoreactivity in vascular dementia and persistent vegetative state evaluated by transcranial harmonic perfusion imaging and Doppler sonography. (12480785)
2002
46
Haemostasis in ischaemic stroke and vascular dementia. (11734665)
2001
47
Factors influencing survival among patients with vascular dementia and Alzheimer's disease. (17895141)
1999
48
Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease. (9701675)
1998
49
Notch3 mutations in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a mendelian condition causing stroke and vascular dementia. (9329692)
1997
50
Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia. (7706432)
1995

Genetic Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Dementia

Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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51QIAGEN
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Pathways related to Vascular Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4TNF, KLK6, KLK1

Compounds for genes affiliated with Vascular Dementia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Vascular Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1rivastigmine44 1111.9APOE, ACHE, BCHE
2metrifonate4410.9BCHE, ACHE, APOE
3ethopropazine44 1111.9CHRM1, ACHE, BCHE
4tacrine44 1111.9ACHE, BCHE, APOE
5Methylphosphinic Acid1110.9BCHE, ACHE
6ambenonium44 1111.9ACHE, BCHE
7donepezil44 11 2412.9ACHE, BCHE, CHRM1, APOE
8thiocholine4410.9BCHE, ACHE
9galantamine44 49 1112.9BCHE, ACHE, APOE
10succinylcholine44 28 1112.9BCHE, ACHE, CHRM1
11Isoflurophate1110.9BCHE, ACHE
12scopolamine44 28 11 2413.9ACHE, BCHE, CHRM1
13alpha-solanine4410.9BCHE, ACHE
14Demecarium1110.9BCHE, ACHE
15Cyclopentolate1110.9CHRM1, BCHE
16acephate59 4411.9ACHE, BCHE
17rivastigmine tartrate5910.9ACHE, BCHE
18fasciculin4410.9ACHE, BCHE
19galanthamine hydrobromide5910.9BCHE, ACHE
20donepezil hydrochloride5910.8BCHE, ACHE
21pralidoxime44 1111.8ACHE, BCHE
22isomalathion4410.8ACHE, BCHE
23obidoxime4410.8ACHE, BCHE
24acetylthiocholine4410.8BCHE, ACHE
25benzoylcholine4410.8BCHE, ACHE
26o-nitroacetanilide4410.8BCHE, ACHE
27butyrylcholine4410.8ACHE, BCHE
28butyrylthiocholine44 1111.8ACHE, BCHE
29echothiophate44 1111.8BCHE, ACHE
30arginine4410.8BCHE, NOTCH3, SREBF2, AVP, CHRM1, APOE
31choline ester4410.8ACHE, BCHE
32bw 284 c 514410.8ACHE, BCHE
33neostigmine44 1111.8BCHE, ACHE
34glycopyrrolate44 1111.8CHRM1, BCHE
35tiapride4410.8BCHE, ACHE
36aldicarb4410.7BCHE, ACHE
37methamidophos4410.7BCHE, ACHE
38carbofuran4410.7BCHE, ACHE
39phenserine44 5911.7ACHE, BCHE
40bambuterol44 1111.7BCHE, ACHE
41edrophonium44 1111.7BCHE, ACHE
42decamethonium44 1111.7ACHE, BCHE
43simvastatin44 49 59 28 11 2415.6SREBF2, BCHE, APOE, TNF
44fenitrothion4410.6ACHE, BCHE
45nicotine44 49 28 1113.5BCHE, CHRM1, APOE, ACHE
46serine4410.5TNF, APOE, AVP, ACHE, KLK6, KLK1
47chlorpyrifos oxon4410.5BCHE, ACHE
48gallamine44 2811.5CHRM1, ACHE
49tabun4410.4ACHE, BCHE
50cyclosarin4410.2ACHE, BCHE

GO Terms for genes affiliated with Vascular Dementia

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16Gene Ontology
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Cellular components related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:03042510.4ACHE, AVP, CHRM1, APOE
2extracellular spaceGO:00561510.3BCHE, TNFSF14, TNF, APOE, ANGPT4, AVP
3extracellular regionGO:00557610.1KLK6, TNF, APOE, ANGPT4, AVP, NOTCH3

Biological processes related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.5BCHE, ACHE, APOE
2positive regulation of membrane protein ectodomain proteolysisGO:05104410.5APOE, TNF
3amyloid precursor protein metabolic processGO:04298210.4ACHE, KLK6
4choline metabolic processGO:01969510.4ACHE, BCHE
5negative regulation of blood vessel endothelial cell migrationGO:04353710.1ANGPT4, APOE

Molecular functions related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholinesterase activityGO:00410410.5BCHE, ACHE
2beta-amyloid bindingGO:00154010.3BCHE, ACHE, APOE
3acetylcholinesterase activityGO:00399010.2BCHE, ACHE

Products for genes affiliated with Vascular Dementia

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Sources for Vascular Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet