MCID: VSC002
MIFTS: 59

Vascular Dementia malady

Mental diseases, Cardiovascular diseases categories
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Summaries for Vascular Dementia

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Disease Ontology:8 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards based summary: Vascular Dementia, also known as dementia, vascular, is related to dementia and cerebrovascular disease. An important gene associated with Vascular Dementia is TNF (tumor necrosis factor), and among its related pathways are Monoamine Transport and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds fasciculin and alpha-solanine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Wikipedia:65 Vascular dementia or multi-infarct dementia is dementia caused by problems in the supply of blood to the... more...

Aliases & Classifications for Vascular Dementia

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 46OMIM, 44Novoseek, 34MeSH, 57SNOMED-CT, 39NCIt, 25ICD10
See all sources

Vascular Dementia, Aliases & Descriptions:

Name: Vascular Dementia 8 10
Dementia, Vascular 46 62
Multi Infarct Dementia 8
 
Multi-Infarct Dementia 62
Multifocal Dementia 8
Dementia Vascular 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:8725
MeSH34 D015161
NCIt39 C34522
ICD1025 F01

Related Diseases for Vascular Dementia

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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.7NOTCH3, BCHE, ACHE, CHRM1, APOE
2cerebrovascular disease30.8NOTCH3, APOE, AVP
3hypertension30.8KLK1, APOE, AVP
4memory impairment30.8APOE, ACHE, BCHE
5binswanger's disease30.8NOTCH3, ACHE, APOE
6alzheimer's disease30.7APOE, CHRM1, ACHE, BCHE, GSTO1, NOTCH3
7hyperhomocysteinemia30.7BCHE, APOE
8lewy body dementia30.5APOE, ACHE, BCHE
9frontotemporal dementia30.4ACHE, APOE
10diabetes mellitus30.4BCHE, APOE, TNF
11pneumonia30.3AVP, TNF, BCHE
12type 2 diabetes mellitus30.2APOE, ACHE, BCHE
13schizophrenia30.1CHRM1, ACHE, BCHE
14brain disease29.9NOTCH3, BCHE
15parkinson's disease29.9GSTO1, BCHE, ACHE, APOE
16obesity29.9TNF, APOE, BCHE
17cerebritis10.7
18cadasil10.5
19abdominal aortic aneurysm10.5APOE
20neuronitis10.4
21cerebral amyloid angiopathy10.4
22progressive supranuclear palsy10.3ACHE, APOE
23pick's disease10.3ACHE, APOE
24anencephaly10.3ACHE, BCHE
25amyloid tumor10.3APOE, ACHE
26alzheimer disease type 210.3BCHE, APOE
27hirschsprung's disease10.3ACHE, BCHE
28neural tube defects10.3ACHE, BCHE
29atherosclerosis10.2
30vascular disease10.2
31myasthenia gravis10.2BCHE, ACHE
32temporal arteritis10.2
33vertebrobasilar insufficiency10.2
34parametritis10.2
35capgras syndrome10.2
36ischemia10.2
37hyperlipidemia type 310.2
38persistent vegetative state10.2
39blindness10.2
40endotheliitis10.2
41hypertriglyceridemia10.1BCHE, APOE
42prion disease10.1BCHE, AVP
43stroke, ischemic10.1NOTCH3, APOE
44brain ischemia10.0
45hydrocephalus10.0
46major depressive disorder10.0
47osteoarthritis10.0
48primary open angle glaucoma10.0
49normal pressure hydrocephalus10.0
50paranoid schizophrenia10.0

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Symptoms for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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MalaCards organs/tissues related to Vascular Dementia:

32
Brain, Cortex, Testes, Temporal lobe, Heart, Endothelial, Spleen, Cerebellum, Kidney, Parietal lobe, Hypothalamus, Caudate nucleus

Animal Models for Vascular Dementia or affiliated genes

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MGI Mouse Phenotypes related to Vascular Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.5NOTCH3, ACHE, CHRM1, APOE
2MP:00053888.2TNF, APOE, CHRM1, ACHE, NOTCH3
3MP:00053898.2TNF, APOE, ACHE, BCHE, NOTCH3
4MP:00107687.9NOTCH3, BCHE, ACHE, APOE, TNF, AVP
5MP:00053867.5AVP, TNF, APOE, CHRM1, ACHE, NOTCH3
6MP:00036317.4AVP, TNF, APOE, CHRM1, ACHE, NOTCH3
7MP:00053766.7NOTCH3, AVP, TNF, APOE, CHRM1, ACHE

Publications for Vascular Dementia

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Articles related to Vascular Dementia:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer's disease. (24175580)
2013
2
The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. (24070657)
2013
3
Trichotillomania in a case of vascular dementia. (23960397)
2013
4
Overestimation of self-reported activities of daily living in vascular dementia patients with a right hemisphere lesion. (21705234)
2013
5
Risk of incident stroke in patients with Alzheimer disease or vascular dementia. (23902701)
2013
6
Plasma viscosity: is a biomarker for the differential diagnosis of Alzheimer's disease and vascular dementia? (23242122)
2013
7
Difficulty with learning of exercise instructions associated with 'working memory' dysfunction and frontal glucose hypometabolism in a patient with very mild subcortical vascular dementia with knee osteoarthritis. (23887984)
2013
8
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
9
Suitability of neuropsychological tests in patients with vascular dementia (VaD). (22694976)
2012
10
Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias. (22133543)
2012
11
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
12
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
13
Gait and equilibrium in subcortical vascular dementia. (21547149)
2011
14
Can Alzheimer's or vascular dementia be prevented with control of vascular risk factors? (21702410)
2011
15
Multichannel linear descriptors analysis for event-related EEG of vascular dementia patients during visual detection task. (21570339)
2011
16
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
17
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. (21419184)
2011
18
Neurobiology of vascular dementia. (21876809)
2011
19
Sleep disturbance and daytime sleepiness predict vascular dementia. (20675705)
2011
20
Genetic associations of autopsy-confirmed vascular dementia subtypes. (21474934)
2011
21
Attention deficits in Alzheimer's disease and vascular dementia. (20145028)
2010
22
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance. (20166891)
2010
23
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
24
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
25
Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. (19222553)
2009
26
Vascular dementia 2007. (19394050)
2009
27
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation. (19550366)
2009
28
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
29
Clinical and therapeutic aspects of vascular dementia. (18631786)
2008
30
Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs. (19337467)
2008
31
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. (18674411)
2008
32
Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project. (17573076)
2007
33
Differential diagnosis of Alzheimer's dementia and vascular dementia. (17544644)
2007
34
Vascular dementia and Alzheimer's disease: a waning dichotomy. (18290307)
2007
35
Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)
2007
36
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
37
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
38
Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)
2006
39
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
40
Links between the pathology of Alzheimer's disease and vascular dementia. (15176482)
2004
41
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. (12876259)
2003
42
Prevention of stroke and vascular dementia]. (12910853)
2003
43
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
44
Vascular dementia]. (11925778)
2002
45
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
46
Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia. (11461168)
2001
47
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
48
Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)
1996
49
Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)
1996
50
Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. (8848934)
1995

Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Expression patterns in normal tissues for genes affiliated with Vascular Dementia

Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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Pathways related to Vascular Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity37
9.8ACHE, TNF
29.8APOE, TNF
39.8KLK1, TNF

Compounds for genes affiliated with Vascular Dementia

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Compounds related to Vascular Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1fasciculin4410.1ACHE, BCHE
2alpha-solanine4410.1ACHE, BCHE
3pralidoxime44 1111.1ACHE, BCHE
4isomalathion4410.1ACHE, BCHE
5galanthamine hydrobromide6110.1BCHE, ACHE
6ambenonium44 1111.1ACHE, BCHE
7acephate61 4411.1ACHE, BCHE
8rivastigmine tartrate6110.1ACHE, BCHE
9donepezil hydrochloride6110.1ACHE, BCHE
10obidoxime4410.1ACHE, BCHE
11acetylthiocholine4410.1ACHE, BCHE
12benzoylcholine4410.1ACHE, BCHE
13butyrylcholine4410.1ACHE, BCHE
14butyrylthiocholine44 1111.0ACHE, BCHE
15o-nitroacetanilide4410.0BCHE, ACHE
16thiocholine4410.0ACHE, BCHE
17choline ester4410.0ACHE, BCHE
18bw 284 c 514410.0ACHE, BCHE
19echothiophate44 1111.0ACHE, BCHE
20carbofuran4410.0ACHE, BCHE
21methamidophos4410.0BCHE, ACHE
22aldicarb4410.0BCHE, ACHE
23decamethonium44 1111.0BCHE, ACHE
24neostigmine44 1111.0ACHE, BCHE
25tiapride4410.0BCHE, ACHE
26bambuterol44 1110.9BCHE, ACHE
27phenserine44 6110.9BCHE, ACHE
28edrophonium44 1110.9BCHE, ACHE
29fenitrothion449.9ACHE, BCHE
30mipafox449.8BCHE, ACHE
31rivastigmine44 1110.7APOE, ACHE, BCHE
32metrifonate449.7BCHE, ACHE, APOE
33tacrine44 1110.7APOE, ACHE, BCHE
34chlorpyrifos oxon449.7ACHE, BCHE
35galantamine44 50 1111.7BCHE, ACHE, APOE
36huperzine a449.7ACHE, BCHE
37tabun449.7ACHE, BCHE
38mivacurium44 1110.6ACHE, BCHE
39glycopyrrolate44 1110.5BCHE, CHRM1
40ethopropazine44 1110.3CHRM1, ACHE, BCHE
41succinylcholine44 50 28 1112.3BCHE, ACHE, CHRM1
42scopolamine44 28 24 1112.3CHRM1, ACHE, BCHE
43atropine44 28 1111.1BCHE, ACHE, CHRM1
44gallamine44 2810.0CHRM1, ACHE
45donepezil44 50 24 1111.9BCHE, ACHE, CHRM1, APOE
46nicotine44 28 50 1111.9APOE, CHRM1, ACHE, BCHE
47acetylcholine44 50 28 24 1112.7APOE, CHRM1, ACHE, BCHE
48glutamate448.0AVP, APOE, CHRM1, ACHE, BCHE
49serine447.9AVP, TNF, APOE, ACHE, BCHE, GSTO1
50arginine447.7AVP, APOE, CHRM1, BCHE, KLK1, NOTCH3

GO Terms for genes affiliated with Vascular Dementia

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Cellular components related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4BCHE, ACHE, APOE, TNF, AVP
2dendriteGO:0304258.2ACHE, CHRM1, APOE, AVP
3extracellular regionGO:0055767.6AVP, TNF, APOE, ACHE, BCHE, NOTCH3

Biological processes related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, APOE
2choline metabolic processGO:0196959.7BCHE, ACHE
3response to glucocorticoidGO:0513849.7BCHE, TNF
4positive regulation of smooth muscle cell proliferationGO:0486619.6NOTCH3, TNF
5synaptic transmission, cholinergicGO:0072719.4BCHE, ACHE, APOE
6positive regulation of peptidyl-serine phosphorylationGO:0331389.3TNF, AVP

Molecular functions related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholinesterase activityGO:0041049.7BCHE, ACHE
2acetylcholinesterase activityGO:0039909.4BCHE, ACHE
3beta-amyloid bindingGO:0015409.2BCHE, ACHE, APOE

Products for genes affiliated with Vascular Dementia

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Sources for Vascular Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet