MCID: VSC002
MIFTS: 59

Vascular Dementia malady

Mental diseases, Cardiovascular diseases categories

Summaries for Vascular Dementia

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards: Vascular Dementia, also known as dementia, vascular, is related to dementia and alzheimer's disease. An important gene associated with Vascular Dementia is TNF (tumor necrosis factor), and among its related pathways are Monoamine Transport and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds fasciculin and alpha-solanine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Wikipedia:66 Vascular dementia or \"multi-infarct dementia\" is dementia caused by problems in the supply of blood to... more...

Aliases & Classifications for Vascular Dementia

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Cardiovascular diseases


Aliases & Descriptions:

vascular dementia 9 11
dementia, vascular 48 63
multi infarct dementia 9
multi-infarct dementia 63
multifocal dementia 9
dementia vascular 46


External Ids:

Disease Ontology9 DOID:8725
NCIt41 C34522
MeSH36 D015161
ICD1026 F01

Related Diseases for Vascular Dementia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.0NOTCH3, BCHE, ACHE, CHRM1, APOE
2alzheimer's disease31.4APOE, CHRM1, ACHE, BCHE, GSTO1, NOTCH3
3cerebrovascular disease30.8NOTCH3, APOE, AVP
4hypertension30.7KLK1, APOE, AVP
5memory impairment30.6APOE, ACHE, BCHE
6binswanger's disease30.6NOTCH3, ACHE, APOE
7diabetes mellitus30.4BCHE, APOE, TNF
8hyperhomocysteinemia30.4BCHE, APOE
9lewy body dementia30.3APOE, ACHE, BCHE
10pneumonia30.2AVP, TNF, BCHE
11parkinson's disease30.1GSTO1, BCHE, ACHE, APOE
12frontotemporal dementia30.1ACHE, APOE
13type 2 diabetes mellitus30.0APOE, ACHE, BCHE
14schizophrenia30.0CHRM1, ACHE, BCHE
15brain disease30.0NOTCH3, BCHE
16obesity30.0TNF, APOE, BCHE
17cerebritis10.7
18cadasil10.5
19cerebral amyloid angiopathy10.3
20neuronitis10.3
21atherosclerosis10.2
22vascular disease10.2
23temporal arteritis10.2
24vertebrobasilar insufficiency10.2
25normal pressure hydrocephalus10.1
26parametritis10.1
27capgras syndrome10.1
28hydrocephalus10.1
29ischemia10.1
30hyperlipidemia type 310.1
31persistent vegetative state10.1
32blindness10.1
33endotheliitis10.1
34abdominal aortic aneurysm10.1APOE
35progressive supranuclear palsy10.1ACHE, APOE
36pick's disease10.1ACHE, APOE
37anencephaly10.1ACHE, BCHE
38amyloid tumor10.1APOE, ACHE
39alzheimer disease type 210.1BCHE, APOE
40hirschsprung's disease10.1ACHE, BCHE
41neural tube defects10.1ACHE, BCHE
42myasthenia gravis10.1BCHE, ACHE
43hypertriglyceridemia10.0BCHE, APOE
44prion disease10.0BCHE, AVP
45stroke, ischemic10.0NOTCH3, APOE
46multiple sclerosis10.0NOTCH3, APOE, TNF
47major depressive disorder10.0
48paranoid schizophrenia10.0
49arteriolosclerosis10.0
50osteoarthritis10.0

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Symptoms for Vascular Dementia

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Drugs & Therapeutics for Vascular Dementia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Dementia

Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Search CenterWatch for Vascular Dementia

Genetic Tests for Vascular Dementia

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Anatomical Context for Vascular Dementia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Vascular Dementia:

34
Brain, Testes, Cortex, Temporal lobe, Heart, Endothelial, Caudate nucleus, Cerebellum, Hypothalamus, Kidney, Spleen, Parietal lobe

Animal Models for Vascular Dementia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Vascular Dementia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.5NOTCH3, ACHE, CHRM1, APOE
2MP:00053888.2TNF, APOE, CHRM1, ACHE, NOTCH3
3MP:00053898.2TNF, APOE, ACHE, BCHE, NOTCH3
4MP:00107687.9NOTCH3, BCHE, ACHE, APOE, TNF, AVP
5MP:00053867.5AVP, TNF, APOE, CHRM1, ACHE, NOTCH3
6MP:00036317.4AVP, TNF, APOE, CHRM1, ACHE, NOTCH3
7MP:00053766.7NOTCH3, AVP, TNF, APOE, CHRM1, ACHE

Publications for Vascular Dementia

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Sources:
53PubMed
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Articles related to Vascular Dementia:

(show top 50)    (show all 606)
idTitleAuthorsYear
1
Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer's disease. (24175580)
2013
2
The molecular and electrophysiological mechanism of buyanghuanwu decoction in learning and memory ability of vascular dementia rats. (24070657)
2013
3
Trichotillomania in a case of vascular dementia. (23960397)
2013
4
Overestimation of self-reported activities of daily living in vascular dementia patients with a right hemisphere lesion. (21705234)
2013
5
Risk of incident stroke in patients with Alzheimer disease or vascular dementia. (23902701)
2013
6
Plasma viscosity: is a biomarker for the differential diagnosis of Alzheimer's disease and vascular dementia? (23242122)
2013
7
Difficulty with learning of exercise instructions associated with 'working memory' dysfunction and frontal glucose hypometabolism in a patient with very mild subcortical vascular dementia with knee osteoarthritis. (23887984)
2013
8
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
9
Suitability of neuropsychological tests in patients with vascular dementia (VaD). (22694976)
2012
10
Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias. (22133543)
2012
11
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
12
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
13
Gait and equilibrium in subcortical vascular dementia. (21547149)
2011
14
Can Alzheimer's or vascular dementia be prevented with control of vascular risk factors? (21702410)
2011
15
Multichannel linear descriptors analysis for event-related EEG of vascular dementia patients during visual detection task. (21570339)
2011
16
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
17
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. (21419184)
2011
18
Neurobiology of vascular dementia. (21876809)
2011
19
Sleep disturbance and daytime sleepiness predict vascular dementia. (20675705)
2011
20
Genetic associations of autopsy-confirmed vascular dementia subtypes. (21474934)
2011
21
Attention deficits in Alzheimer's disease and vascular dementia. (20145028)
2010
22
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance. (20166891)
2010
23
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
24
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
25
Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. (19222553)
2009
26
Vascular dementia 2007. (19394050)
2009
27
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation. (19550366)
2009
28
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
29
Clinical and therapeutic aspects of vascular dementia. (18631786)
2008
30
Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs. (19337467)
2008
31
Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study. (18674411)
2008
32
Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project. (17573076)
2007
33
Differential diagnosis of Alzheimer's dementia and vascular dementia. (17544644)
2007
34
Vascular dementia and Alzheimer's disease: a waning dichotomy. (18290307)
2007
35
Occludin is overexpressed in Alzheimer's disease and vascular dementia. (17635647)
2007
36
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
37
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
38
Polymorphism of apolipoproteine E in relation with Alzheimer and vascular dementia. (16758323)
2006
39
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
40
Links between the pathology of Alzheimer's disease and vascular dementia. (15176482)
2004
41
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. (12876259)
2003
42
Prevention of stroke and vascular dementia]. (12910853)
2003
43
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
44
Vascular dementia]. (11925778)
2002
45
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. (11965273)
2002
46
Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia. (11461168)
2001
47
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
48
Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)
1996
49
Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)
1996
50
Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. (8848934)
1995

Variations for Vascular Dementia

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Expression for genes affiliated with Vascular Dementia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Dementia

Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN
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Pathways related to Vascular Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity39
9.8ACHE, TNF
29.8APOE, TNF
39.8KLK1, TNF

Compounds for genes affiliated with Vascular Dementia

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Vascular Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1fasciculin4610.1ACHE, BCHE
2alpha-solanine4610.1ACHE, BCHE
3pralidoxime46 1211.1ACHE, BCHE
4isomalathion4610.1ACHE, BCHE
5galanthamine hydrobromide6210.1BCHE, ACHE
6ambenonium46 1211.1ACHE, BCHE
7acephate62 4611.1ACHE, BCHE
8rivastigmine tartrate6210.1ACHE, BCHE
9donepezil hydrochloride6210.1ACHE, BCHE
10obidoxime4610.1ACHE, BCHE
11acetylthiocholine4610.1ACHE, BCHE
12benzoylcholine4610.1ACHE, BCHE
13butyrylcholine4610.1ACHE, BCHE
14butyrylthiocholine46 1211.0ACHE, BCHE
15o-nitroacetanilide4610.0BCHE, ACHE
16thiocholine4610.0ACHE, BCHE
17choline ester4610.0ACHE, BCHE
18bw 284 c 514610.0ACHE, BCHE
19echothiophate46 1211.0ACHE, BCHE
20carbofuran4610.0ACHE, BCHE
21methamidophos4610.0BCHE, ACHE
22aldicarb4610.0BCHE, ACHE
23decamethonium46 1211.0BCHE, ACHE
24neostigmine46 1211.0ACHE, BCHE
25tiapride4610.0BCHE, ACHE
26bambuterol46 1210.9BCHE, ACHE
27phenserine46 6210.9BCHE, ACHE
28edrophonium46 1210.9BCHE, ACHE
29fenitrothion469.9ACHE, BCHE
30mipafox469.8BCHE, ACHE
31rivastigmine46 1210.7APOE, ACHE, BCHE
32metrifonate469.7BCHE, ACHE, APOE
33tacrine46 1210.7APOE, ACHE, BCHE
34chlorpyrifos oxon469.7ACHE, BCHE
35galantamine46 52 1211.7BCHE, ACHE, APOE
36huperzine a469.7ACHE, BCHE
37tabun469.7ACHE, BCHE
38mivacurium46 1210.6ACHE, BCHE
39glycopyrrolate46 1210.5BCHE, CHRM1
40ethopropazine46 1210.3CHRM1, ACHE, BCHE
41succinylcholine46 52 30 1212.3BCHE, ACHE, CHRM1
42scopolamine46 30 25 1212.3CHRM1, ACHE, BCHE
43atropine46 30 1211.1BCHE, ACHE, CHRM1
44gallamine46 3010.0CHRM1, ACHE
45donepezil46 52 25 1211.9BCHE, ACHE, CHRM1, APOE
46nicotine46 30 52 1211.9APOE, CHRM1, ACHE, BCHE
47acetylcholine46 52 30 25 1212.7APOE, CHRM1, ACHE, BCHE
48glutamate468.0AVP, APOE, CHRM1, ACHE, BCHE
49serine467.9AVP, TNF, APOE, ACHE, BCHE, GSTO1
50arginine467.7AVP, APOE, CHRM1, BCHE, KLK1, NOTCH3

GO Terms for genes affiliated with Vascular Dementia

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17Gene Ontology
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Cellular components related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4BCHE, ACHE, APOE, TNF, AVP
2dendriteGO:0304258.2ACHE, CHRM1, APOE, AVP
3extracellular regionGO:0055767.6AVP, TNF, APOE, ACHE, BCHE, NOTCH3

Biological processes related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, APOE
2choline metabolic processGO:0196959.7BCHE, ACHE
3response to glucocorticoidGO:0513849.7BCHE, TNF
4positive regulation of smooth muscle cell proliferationGO:0486619.6NOTCH3, TNF
5synaptic transmission, cholinergicGO:0072719.4BCHE, ACHE, APOE
6positive regulation of peptidyl-serine phosphorylationGO:0331389.3TNF, AVP

Molecular functions related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholinesterase activityGO:0041049.7BCHE, ACHE
2acetylcholinesterase activityGO:0039909.4BCHE, ACHE
3beta-amyloid bindingGO:0015409.2BCHE, ACHE, APOE

Products for genes affiliated with Vascular Dementia

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  • Antibodies
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Sources for Vascular Dementia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet