MCID: VSC002
MIFTS: 55

Vascular Dementia malady

Neuronal, Cardiovascular categories

Summaries for Vascular Dementia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

MalaCards: Vascular Dementia, also known as dementia, vascular, is related to vascular disease and alzheimer's disease. An important gene associated with Vascular Dementia is TNF (tumor necrosis factor), and among its related pathways is MSP-RON Signaling. The compounds rivastigmine and metrifonate have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and spleen, and related mouse phenotype homeostasis/metabolism.

Wikipedia:64 Vascular dementia or \"multi-infarct dementia\" is dementia caused by problems in the supply of blood to... more...

Aliases & Classifications for Vascular Dementia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 47OMIM, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Cardiovascular


Aliases & Descriptions:

vascular dementia 8 10
dementia, vascular 47 61
multi infarct dementia 8
multi-infarct dementia 61
multifocal dementia 8
dementia vascular 45


External Ids:

Disease Ontology8 DOID:8725
MeSH35 D015161
NCIt40 C34522
ICD1025 F01

Related Diseases for Vascular Dementia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vascular Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.7BCHE, TNF
2alzheimer's disease31.4KLK6, APOE, AOC3, NEFL, CHRM1, NOTCH3
3cadasil30.7APOE, AOC3, AVP, NOTCH3
4memory impairment30.5BCHE, ACHE, APOE
5cerebral amyloid angiopathy30.5APOE, AOC3
6stroke, ischemic30.4NOTCH3, AOC3
7binswanger's disease30.2ACHE, NOTCH3, APOE
8frontotemporal dementia30.2ACHE, APOE
9lewy body dementia30.2APOE
10parkinson's disease29.9APOE
11dementia - subcortical10.9
12brain disease10.3
13alzheimer disease risk factor10.3
14vascular cancer10.3
15hyperhomocysteinemia10.2
16atherosclerosis10.2
17lip disease10.2
18vertebrobasilar insufficiency10.2
19temporal arteritis10.2
20peripheral vascular disease10.1
21capgras syndrome10.1
22normal pressure hydrocephalus10.1
23n syndrome10.1
24hyperlipidemia type 310.1
25persistent vegetative state10.1
26hypertension10.0AVP, APOE, KLK1
27ovarian cancer10.0KLK6, KLK1
28neuropathy10.0NEFL
29dementia10.0BCHE, APOE, CHRM1, NOTCH3, ACHE
30breast cancer10.0KLK6, TNFSF14, ANGPT4, BCHE
31progressive supranuclear palsy10.0ACHE, NEFL, APOE
32prion disease10.0BCHE, AVP
33amyotrophic lateral sclerosis10.0NEFL
34cerebrovascular disease10.0APOE, NOTCH3, ACHE
35schizophrenia10.0NEFL, CHRM1, ACHE, BCHE
36prostate cancer10.0KLK6, AOC3, CHRM1, SREBF2
37hypertriglyceridemia10.0APOE, BCHE
38myopathy10.0NEFL, NOTCH3, ACHE
39myasthenia gravis10.0ACHE, BCHE
40abdominal aortic aneurysm10.0APOE
41type 2 diabetes mellitus10.0BCHE, ACHE, AOC3, APOE
42diabetic retinopathy10.0AOC3, OCLN
43familial hyperlipidemia10.0APOE, ACHE, SREBF2
44pick's disease10.0ACHE, APOE
45hypothyroidism10.0AVP
46colon cancer10.0ACHE, TNFSF14
47alzheimer disease type 210.0APOE, BCHE
48psoriasis10.0AOC3, TNF, KLK6
49diabetes mellitus10.0TNF, APOE, AOC3, BCHE
50multiple sclerosis10.0TNF, APOE, AOC3, NEFL, NOTCH3

Graphical network of the top 20 diseases related to Vascular Dementia:



Diseases related to vascular dementia

Clinical Features for Vascular Dementia

Drugs & Therapeutics for Vascular Dementia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vascular Dementia

Drug clinical trials:

Search ClinicalTrials for Vascular Dementia

Search NIH Clinical Center for Vascular Dementia

Search CenterWatch for Vascular Dementia

Genetic Tests for Vascular Dementia

Anatomical Context for Vascular Dementia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vascular Dementia:

33
Brain, Kidney, Spleen, Whole blood, Cortex, Cerebellum, Heart, B cells, Endothelial, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Hypothalamus, Caudate nucleus

Animal Models for Vascular Dementia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Vascular Dementia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.3GSTO1, APOE, OCLN, CHRM1, AVP, NOTCH3

Publications for Vascular Dementia

Sources:
51PubMed
See all sources

Articles related to Vascular Dementia:

(show top 50)    (show all 653)
idTitleAuthorsYear
1
Overestimation of self-reported activities of daily living in vascular dementia patients with a right hemisphere lesion. (21705234)
2013
2
The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia. (23403102)
2013
3
Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. (23637108)
2013
4
Cognitive rehabilitation reduces cognitive impairment and normalizes hippocampal CA1 architecture in a rat model of vascular dementia. (23423187)
2013
5
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
6
Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases. (22664153)
2012
7
Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia. (21074291)
2012
8
Comparison of hippocampal volume measured using magnetic resonance imaging in Alzheimer's disease, vascular dementia, mild cognitive impairment and pseudodementia. (22613435)
2012
9
ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis. (21984189)
2012
10
Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. (22381401)
2012
11
Cell-to-cell communication and vascular dementia. (22372561)
2012
12
An update on type 2 diabetes, vascular dementia and Alzheimer's disease. (22884853)
2012
13
Neurobiology of vascular dementia. (21876809)
2011
14
Sleep disturbance and daytime sleepiness predict vascular dementia. (20675705)
2011
15
Clinical and economic characteristics associated with direct costs of Alzheimer's, frontotemporal and vascular dementia in Argentina. (21044400)
2011
16
The central histamine level in rat model of vascular dementia. (22204803)
2011
17
Capgras syndrome and vascular dementia. (20160238)
2010
18
Association between APOE epsilon4 allele and vascular dementia: The Cache County study. (20375505)
2010
19
Systematic review of statins for the prevention of vascular dementia or dementia. (20100290)
2010
20
Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type. (19220710)
2010
21
Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains. (20041969)
2010
22
Korean Addenbrooke's Cognitive Examination Revised (K-ACER) for differential diagnosis of Alzheimer's disease and subcortical ischemic vascular dementia. (20497240)
2010
23
Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia. (20505437)
2010
24
Computer-aided evaluation method of white matter hyperintensities related to subcortical vascular dementia based on magnetic resonance imaging. (20116974)
2010
25
Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia. (19483658)
2009
26
Assessing the validity of deriving clinical dementia rating (CDR) global scores from independently-obtained functional rating scale (FRS) scores in vascular dementia with and without Alzheimer's disease. (19768698)
2009
27
Is it possible to treat vascular dementia? (19182467)
2009
28
Vascular and biochemical risk factors of vascular dementia after lacunar strokes (S-VaD) and after multiinfarcts in strategic areas (M-VaD). (19339023)
2009
29
Clinical effects of acupuncture combined with nimodipine for treatment of vascular dementia in 30 cases. (19894378)
2009
30
The potential for estrogens in preventing Alzheimer's disease and vascular dementia. (19890493)
2009
31
Serum HDL, LDL and total cholesterol in patients with late-life onset of Alzheimer's disease versus vascular dementia. (20055246)
2009
32
Pathophysiology of vascular dementia. (19895675)
2009
33
Vasoreactivity induced by acetazolamide in patients with vascular dementia versus Alzheimer's disease. (19375084)
2009
34
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
35
Diagnostic criteria of vascular dementia in CADASIL. (18258841)
2008
36
Incidence of dementia, Alzheimer disease, and vascular dementia in a Japanese population: Radiation Effects Research Foundation adult health study. (18382114)
2008
37
Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition. (17726571)
2008
38
Absence of association between codon 129 and 219 polymorphisms of the prion protein gene and vascular dementia. (17570906)
2007
39
Treatment of vascular dementia and vascular cognitive impairment. (17215726)
2007
40
Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia. (16961066)
2006
41
Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia. (16465461)
2006
42
Neuroprotection in vascular dementia. (16651821)
2006
43
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
44
Validation of the HIV Dementia Scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus. (15087586)
2004
45
Lack of association between interleukin-1alpha polymorphism and Alzheimer disease or vascular dementia. (12794386)
2003
46
Paraoxonase 1 activity: a new vascular marker of dementia? (12480737)
2002
47
Risk factors for vascular disease and dementia. (10420064)
1998
48
Presenilin-1 polymorphism in Alzheimer's disease and vascular dementia. (9270069)
1997
49
The apolipoprotein E gene in Binswanger's disease and vascular dementia. (9147873)
1996
50
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). A vascular etiology of dementia. (1006740)
1976

Genetic Variations for Vascular Dementia

Expression for genes affiliated with Vascular Dementia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vascular Dementia

Search GEO for disease gene expression data for Vascular Dementia.

Pathways for genes affiliated with Vascular Dementia

Sources:
52QIAGEN
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Pathways related to Vascular Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4TNF, KLK6, KLK1

Compounds for genes affiliated with Vascular Dementia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Vascular Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1rivastigmine45 1111.9APOE, ACHE, BCHE
2metrifonate4510.9BCHE, ACHE, APOE
3ethopropazine45 1111.9ACHE, BCHE, CHRM1
4tacrine45 1111.9BCHE, APOE, ACHE
5Methylphosphinic Acid1110.9BCHE, ACHE
6ambenonium45 1111.9ACHE, BCHE
7donepezil45 11 2412.9ACHE, BCHE, APOE, CHRM1
8thiocholine4510.9BCHE, ACHE
9galantamine45 50 1112.9BCHE, ACHE, APOE
10succinylcholine45 29 1112.9BCHE, ACHE, CHRM1
11Isoflurophate1110.9BCHE, ACHE
12scopolamine45 29 11 2413.9ACHE, BCHE, CHRM1
13alpha-solanine4510.9BCHE, ACHE
14Demecarium1110.9BCHE, ACHE
15Cyclopentolate1110.9CHRM1, BCHE
16obidoxime4510.9BCHE, ACHE
17fasciculin4510.9ACHE, BCHE
18galanthamine hydrobromide6010.9BCHE, ACHE
19donepezil hydrochloride6010.9BCHE, ACHE
20pralidoxime45 1111.8ACHE, BCHE
21isomalathion4510.8ACHE, BCHE
22rivastigmine tartrate6010.8BCHE, ACHE
23acephate60 4511.8ACHE, BCHE
24o-nitroacetanilide4510.8BCHE, ACHE
25acetylthiocholine4510.8BCHE, ACHE
26benzoylcholine4510.8ACHE, BCHE
27butyrylcholine4510.8ACHE, BCHE
28butyrylthiocholine45 1111.8ACHE, BCHE
29echothiophate45 1111.8BCHE, ACHE
30arginine4510.8BCHE, NOTCH3, SREBF2, AVP, CHRM1, APOE
31choline ester4510.8ACHE, BCHE
32bw 284 c 514510.8BCHE, ACHE
33neostigmine45 1111.8BCHE, ACHE
34glycopyrrolate45 1111.8CHRM1, BCHE
35tiapride4510.8BCHE, ACHE
36methamidophos4510.7BCHE, ACHE
37aldicarb4510.7BCHE, ACHE
38carbofuran4510.7BCHE, ACHE
39decamethonium45 1111.7BCHE, ACHE
40bambuterol45 1111.7BCHE, ACHE
41edrophonium45 1111.7BCHE, ACHE
42phenserine45 6011.7ACHE, BCHE
43simvastatin45 50 60 29 11 2415.6SREBF2, BCHE, APOE, TNF
44fenitrothion4510.6ACHE, BCHE
45nicotine45 50 29 1113.5ACHE, APOE, BCHE, CHRM1
46serine4510.5KLK6, TNF, APOE, KLK1, AVP, ACHE
47mivacurium45 1111.5BCHE, ACHE
48gallamine45 2911.5CHRM1, ACHE
49mipafox4510.4BCHE, ACHE
50huperzine a4510.2ACHE, BCHE

GO Terms for genes affiliated with Vascular Dementia

Sources:
16Gene Ontology
See all sources

Cellular components related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:03042510.4ACHE, AVP, CHRM1, APOE
2extracellular spaceGO:00561510.3ACHE, TNFSF14, TNF, APOE, ANGPT4, AVP
3extracellular regionGO:00557610.1BCHE, KLK6, ACHE, NOTCH3, AVP, ANGPT4

Biological processes related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.5BCHE, ACHE, APOE
2positive regulation of membrane protein ectodomain proteolysisGO:05104410.5APOE, TNF
3amyloid precursor protein metabolic processGO:04298210.4KLK6, ACHE
4choline metabolic processGO:01969510.4ACHE, BCHE
5negative regulation of blood vessel endothelial cell migrationGO:04353710.1ANGPT4, APOE

Molecular functions related to Vascular Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholinesterase activityGO:00410410.5BCHE, ACHE
2beta-amyloid bindingGO:00154010.3BCHE, ACHE, APOE
3acetylcholinesterase activityGO:00399010.2BCHE, ACHE

Products for genes affiliated with Vascular Dementia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vascular Dementia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet