MCID: VSC007
MIFTS: 70

Vascular Disease malady

Mental diseases, Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Vascular Disease

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and hypertension. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are A-beta Plaque Formation and APP Metabolism and Cell adhesion ECM remodeling. The compounds gliclazide and fosinopril have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.

Wikipedia:66 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Aliases & Classifications for Vascular Disease

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Sources:
9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Related Diseases for Vascular Disease

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18GeneCards, 19GeneDecks
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Diseases related to Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 437)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.7SELE, SELP, VCAM1, MTHFR
2hypertension30.7ALB, CRP, PPBP, SERPINE1, SELE, VCAM1
3systemic lupus erythematosus30.6CRP
4dementia30.4AGER, CST3, CETP
5homocysteinemia30.4MTHFR
6coronary artery disease30.4SERPINE1, SELP, CETP, ACE, CRP
7diabetes mellitus30.3MTHFR, ACE, CST3, ALB, CRP, AGER
8ischemia30.3CST3, SELP, SELE, VEGFA
9obesity30.3SFTPD, APOA2, SERPINE1, SELE, CETP, CRP
10hyperhomocysteinemia30.3VCAM1, MTHFR, CST3, ALB, CRP, SELP
11arthritis30.3AGER, CRP, ALB, SELE
12arteriosclerosis30.2MTHFR, VCAM1, SERPINE1
13systemic scleroderma30.2ACE
14alzheimer's disease30.2PPBP, PON2, CETP, CST3, AGER
15antiphospholipid syndrome30.2MTHFR, VCAM1, SELP, SELE
16atherosclerosis30.2PON2, VCAM1, CETP, MTHFR, ACE, CST3
17insulin resistance30.2APOA2, SERPINE1, SELE, VCAM1, CETP, ACE
18thromboembolism30.1SERPINE1, SELP, MTHFR
19renal artery disease30.1ALB, ACE
20diabetic nephropathy30.1SERPINE1, PON2, MTHFR, ACE, CST3, ALB
21peritonitis30.1CRP, ALB, SELP
22connective tissue disease30.0SELE, VCAM1, ALB
23carotid stenosis30.0SELP, CRP
24type 2 diabetes mellitus30.0APOA2, SERPINE1, SELE, SELP, PON2, VCAM1
25vasculitis30.0PPBP, SELE, SELP, VCAM1, ALB, CRP
26thrombophilia29.9PPBP, SERPINE1, SELE, SELP, MTHFR
27type 1 diabetes mellitus29.9ALB, CST3, ACE, CETP
28hyperglycemia29.9SERPINE1, SELE, VCAM1, CETP, ACE, ALB
29polycystic ovary syndrome29.9SERPINE1, CRP, AGER
30rheumatoid arthritis29.9PPBP, SFTPD, VEGFA, SELE, SELP, VCAM1
31uremia29.8VCAM1, ALB, CRP, AGER
32myocardial infarction29.8CRP, AGER, FGB, CST3, ACE, MTHFR
33eclampsia29.8MTHFR
34hypertriglyceridemia29.8APOA2, SERPINE1, SELE, VCAM1, CETP
35central retinal vein occlusion29.8VEGFA, MTHFR
36retinal vein occlusion29.8VEGFA, MTHFR
37vascular dementia29.8VEGFA, MTHFR, CST3
38collagen disease29.8CRP
39diabetic angiopathy29.7SELE, AGER
40arteriosclerosis obliterans29.7SELP, VCAM1
41nephritis29.7ALB, ACE, VCAM1
42essential hypertension29.7PPBP, SERPINE1, SELP, CETP, ACE, CST3
43pancreatitis29.7CRP, ALB, SELP
44kawasaki disease29.6CRP, SELE
45cerebrovascular disease29.6SELP, CETP, MTHFR, ACE, CST3
46congenital heart disease29.6CST3, ACE, CETP, PPBP
47thrombocytopenia29.6ALB, SELP, PPBP
48thrombocytosis29.6PPBP, SELP, CRP
49venous thrombosis29.6FGB, MTHFR, CETP, SELP, SERPINE1
50inflammatory bowel disease29.6SELE, SELP, VCAM1, CRP

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Symptoms for Vascular Disease

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Drugs & Therapeutics for Vascular Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Vascular Disease

Search NIH Clinical Center for Vascular Disease

Search CenterWatch for Vascular Disease

Genetic Tests for Vascular Disease

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Anatomical Context for Vascular Disease

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34MalaCards
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MalaCards organs/tissues related to Vascular Disease:

34
Heart, Endothelial, Brain, Kidney, Spinal cord, Bone, Skin, Smooth muscle, Lung, Monocytes, Retina, Testes, Pancreas, Skeletal muscle, Pons, Ovary, Bone marrow, Eye, Liver, Cortex, Prostate, Adipocyte, B cells, Nk cells, Myeloid, Breast, Colon, Whole blood, Lymph node

Animal Models for Vascular Disease or affiliated genes

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38MGI
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Publications for Vascular Disease

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53PubMed
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Articles related to Vascular Disease:

(show top 50)    (show all 1544)
idTitleAuthorsYear
1
Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study. (24430876)
2014
2
Extracellular vesicle-derived CD14 is independently associated with the extent of cardiovascular disease burden in patients with manifest vascular disease. (24398371)
2014
3
Diabetes mellitus and peripheral vascular disease: diagnosis and management. (24296015)
2014
4
Bioreactors as engineering support to treat cardiac muscle and vascular disease. (23965594)
2013
5
Impact of Smoking on Long-Term Outcomes in Patients with Atherosclerotic Vascular Disease Treated with Aspirin or Clopidogrel: Insights from the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) Trial. (24239662)
2013
6
Impact of estimated glomerular filtration rate on vascular disease extent and adverse cardiovascular events in patients without chronic kidney disease. (23317678)
2013
7
Relation between aortic valve sclerosis and ankle-brachial index in participants clinically free of atherosclerotic vascular disease. (23267238)
2013
8
Peripheral vascular disease as remote ischemic preconditioning, for acute stroke. (23958050)
2013
9
Mitochondria in vascular disease. (22392270)
2012
10
Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease. (22272893)
2012
11
The risk of general and abdominal adiposity in the occurrence of new vascular events and mortality in patients with various manifestations of vascular disease. (21712810)
2012
12
Initial experience with the 5 A9 300-mm Proteus embolic capture angioplasty balloon in the treatment of peripheral vascular disease. (23210883)
2012
13
Pretreatment of endothelial progenitor cells with osteopontin enhances cell therapy for peripheral vascular disease. (22304991)
2012
14
Bile pigments in pulmonary and vascular disease. (22408625)
2012
15
Polycystic ovary syndrome: a common endocrine disorder and risk factor for vascular disease. (21562798)
2011
16
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. (21069462)
2011
17
An option for intraoperative placement of an intra-aortic balloon pump in patients with occlusive peripheral vascular disease. (20633901)
2011
18
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
19
The nuclear factor--kappa B pathway in atherosclerosis: a potential therapeutic target for atherothrombotic vascular disease. (21636112)
2011
20
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
21
The influence of basic ventilation strategies on cerebral oxygenation in anesthetized patients without vascular disease. (21061050)
2010
22
Non-invasive imaging of diabetic vascular disease. (21154315)
2010
23
The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease. (19724159)
2009
24
Versican degradation and vascular disease. (16839865)
2006
25
Percutaneous continuous aortic flow augmentation for cardiac recovery in a chronic heart failure patient with peripheral vascular disease. (17170590)
2006
26
Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped. (15654296)
2005
27
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (15051034)
2004
28
Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. (14998419)
2004
29
RHO SIGNALING in vascular diseases. (15616164)
2004
30
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. (12777673)
2003
31
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. (12805074)
2003
32
Effects of cilostazol on serum lipid concentrations and plasma fatty acid composition in type 2 diabetic patients with peripheral vascular disease. (12624709)
2003
33
MR angiography for assessment of peripheral vascular disease. (12171187)
2002
34
Ethnic differences in peripheral vascular disease. (12425370)
2002
35
ABC of arterial and vascular disease. Secondary prevention of peripheral vascular disease. (10797042)
2000
36
ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients. (11124487)
2000
37
Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation. (10638832)
1999
38
Is clopidogrel markedly superior to aspirin in patients with peripheral vascular disease? (16793749)
1998
39
Renal vascular disease in the elderly. (9839288)
1998
40
Homocysteinemia: new information about an old risk factor for vascular disease. (10537928)
1998
41
Von Willebrand factor and soluble E-selectin in hyperlipidaemia: relationship to lipids and vascular disease. (9136912)
1997
42
Vascular permeability/vascular endothelial growth factors: a potential role in the pathogenesis and treatment of vascular diseases. (9552580)
1996
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. (8281664)
1994
45
Semiconductor diode laser photocoagulation in retinal vascular disease. (2255529)
1990
46
The tunable dye laser in the management of retinal vascular disease. (3229908)
1988
47
Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease. (3680515)
1987
48
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
49
Photocoagulation of retinal vascular disease. (4507180)
1972
50
Linear scleroderma with hemiatrophy: report of three cases associated with collagen-vascular disease. (5907143)
1966

Variations for Vascular Disease

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Expression for genes affiliated with Vascular Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Disease

Search GEO for disease gene expression data for Vascular Disease.

Pathways for genes affiliated with Vascular Disease

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Sources:
51PathCards, 55R&D Systems, 61Thomson Reuters, 13EMD Millipore, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Vascular Disease

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1gliclazide46 52 1211.7VEGFA, SELE, VCAM1, ALB
2fosinopril46 1210.7SERPINE1, ACE, ALB, CRP
3telmisartan46 30 1211.6ACE, ALB, AGER, CRP
4hydrochlorothiazide46 30 52 25 1213.5ALB, SERPINE1, ACE, CRP
5ramipril46 1210.5SERPINE1, CST3, ALB, CRP, ACE
6kininogen469.5ALB, SERPINE1, CST3, SELP, ACE
7carvedilol46 52 30 1212.5ACE, SELE, VEGFA, VCAM1
8amlodipine46 52 25 1212.5VCAM1, SERPINE1, ACE, ALB
9perindopril46 52 1211.5SERPINE1, VEGFA, CRP, ALB, ACE
10metformin46 52 1211.4MTHFR, CRP, AGER, ACE, SERPINE1
11valsartan46 62 30 1212.4ACE, CRP, SELP, SERPINE1, ALB
12candesartan46 52 30 1212.3SERPINE1, SELP, ACE, VEGFA, ALB, AGER
13quinapril46 52 1211.3SERPINE1, SELE, SELP, ACE, CRP
14uric acid46 2510.3AGER, ALB, SERPINE1, CRP, CST3, MTHFR
15sele469.3SELP, VCAM1, ACE, CETP, SELE, MTHFR
16iohexol469.2CST3, SELP, PPBP, ALB
17alpha tocopherol469.2CETP, MTHFR, CRP, ALB, VCAM1
18folate469.2CRP, ALB, CST3, MTHFR, VCAM1, SELE
19methotrexate52 46 1211.1SERPINE1, ALB, CRP, SELE, CST3, MTHFR
208-isoprostane469.1CRP, VCAM1, SERPINE1, SELE
21cyclophosphamide46 52 1211.1SELE, VCAM1, CRP, VEGFA, MTHFR, SERPINE1
22warfarin46 52 25 1212.0SELP, MTHFR, PPBP, ALB, ACE
23n acetylcysteine468.8CRP, CST3, VCAM1, SELP, SELE, VEGFA
24mannitol46 129.8CRP, SERPINE1, VCAM1, SELP, ALB
25losartan46 52 30 1211.8SELP, SERPINE1, VCAM1, ACE, ALB, CRP
26fluvastatin46 52 30 1211.7VCAM1, CRP, ACE, CETP, SERPINE1, SELE
27simvastatin46 52 62 30 25 1213.7VEGFA, SERPINE1, CETP, CRP, SELE, VCAM1
28fenofibrate46 52 1210.6CRP, VCAM1, SELP, SERPINE1, APOA2, SELE
29rosiglitazone30 46 52 25 1212.6CRP, SERPINE1, SELE, VCAM1, ALB
30iloprost62 30 46 1211.6SELE, SELP, VCAM1, PPBP
31polysulfone468.5SELP, CRP, ALB, VCAM1, PPBP, CST3
32pravastatin46 52 30 25 1212.5SELE, SERPINE1, SELP, CETP, MTHFR, ACE
33atorvastatin46 52 30 25 1212.5SELP, VEGFA, CRP, ACE, CETP, VCAM1
34testosterone46 62 25 1211.5KLK15, ALB, SERPINE1, SELE, VCAM1, MTHFR
35aspartate468.3CETP, CST3, MTHFR, ALB, CRP, SELE
36aspirin46 52 30 2511.0PPBP, ACE, SERPINE1, SELE, SELP, CETP
37alanine467.8PPBP, SELE, VCAM1, CRP, ALB, CST3
38homocysteine46 258.8VCAM1, SELP, CETP, BHMT2, CRP, ALB
39lactate467.8CRP, CST3, SELE, SFTPD, PPBP, ALB
40prostacyclin467.7AGER, CRP, VCAM1, SELP, SELE, SERPINE1
41creatinine467.7ACE, MTHFR, SELP, SELE, SERPINE1, ALB
42vegf467.7SELE, VCAM1, AGER, CRP, CST3, SELP
43nitric oxide46 25 129.7SFTPD, SELE, VCAM1, ACE, AGER, SELP
44fibrinogen467.3PPBP, APOA2, SERPINE1, SELE, SELP, VCAM1
45cysteine467.2ALB, CST3, PPBP, SELP, VCAM1, CETP
46heparin46 30 25 1210.1PPBP, VEGFA, APOA2, SERPINE1, SELE, SELP
47lipid466.6ACE, CETP, VCAM1, PON2, SELE, SERPINE1
48glucose466.6VCAM1, PON2, ACE, PPBP, APOA2, SFTPD
49serine466.3SERPINE1, PPBP, VCAM1, CETP, MTHFR, RARRES2
50cholesterol46 30 25 129.1PPBP, SFTPD, APOA2, SERPINE1, AGER, CRP

GO Terms for genes affiliated with Vascular Disease

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17Gene Ontology
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Cellular components related to Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.6APOA2, FGB, ALB
2high-density lipoprotein particleGO:0343649.6APOA2, CETP
3external side of plasma membraneGO:0098979.3SELP, VCAM1, ACE, FGB
4extracellular vesicular exosomeGO:0700628.7APOA2, CETP, ACE, ALB, BHMT2, CST3
5platelet alpha granule lumenGO:0310938.7PPBP, VEGFA, SERPINE1, ALB, FGB
6extracellular spaceGO:0056156.2PPBP, SFTPD, VEGFA, SERPINE1, SELE, SELP
7extracellular regionGO:0055765.7FGB, PPBP, SFTPD, VEGFA, APOA2, SERPINE1

Biological processes related to Vascular Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1induction of positive chemotaxisGO:05093010.1AGER, VEGFA
2low-density lipoprotein particle remodelingGO:03437410.1CETP, APOA2
3surfactant homeostasisGO:04312910.0VEGFA, SFTPD
4methionine biosynthetic processGO:00908610.0BHMT2, MTHFR
5high-density lipoprotein particle remodelingGO:03437510.0CETP, APOA2
6positive regulation of leukocyte migrationGO:00268710.0SELP, SELE, VEGFA
7acute inflammatory responseGO:00252610.0VCAM1, APOA2
8negative regulation of macrophage derived foam cell differentiationGO:0107459.9CETP, CRP
9lipoprotein metabolic processGO:0421579.9APOA2, CETP, ALB
10cellular response to vascular endothelial growth factor stimulusGO:0359249.9VCAM1, VEGFA
11leukocyte tethering or rollingGO:0509019.8SELE, SELP, VCAM1
12leukocyte cell-cell adhesionGO:0071599.8VCAM1, SELP, SELE
13reverse cholesterol transportGO:0436919.8CETP, APOA2
14heterophilic cell-cell adhesionGO:0071579.8SELE, SELP, VCAM1
15positive regulation of receptor internalizationGO:0020929.7SELE, VEGFA
16response to hypoxiaGO:0016669.6CRP, MTHFR, VCAM1, VEGFA
17response to lipopolysaccharideGO:0324969.5SELE, SELP, VCAM1
18inflammatory responseGO:0069548.9SELE, SELP, CRP, RARRES2, AGER
19platelet degranulationGO:0025768.6FGB, ALB, SELP, SERPINE1, VEGFA, PPBP
20platelet activationGO:0301688.6PPBP, VEGFA, SERPINE1, SELP, ALB, FGB
21blood coagulationGO:0075968.4PPBP, VEGFA, SERPINE1, SELE, SELP, ALB

Molecular functions related to Vascular Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oligosaccharide bindingGO:0704929.9SELP, SELE
2lipid transporter activityGO:0053199.9APOA2, CETP
3sialic acid bindingGO:0336919.9SELP, SELE
4cholesterol transporter activityGO:0171279.8CETP, APOA2
5cholesterol bindingGO:0154859.6APOA2, CRP, CETP
6phosphatidylcholine bindingGO:0312109.6CETP, APOA2
7protein bindingGO:0055156.6VEGFA, SFTPD, APOA2, SERPINE1, SELE, SELP

Products for genes affiliated with Vascular Disease

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  • Antibodies
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Sources for Vascular Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet