Vascular Disease malady

MedlinePlus: The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.²³

MalaCards: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and hyperhomocysteinemia. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are MAPK Signaling and Glioma Invasiveness. The compounds glucose and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and retina, and related mouse phenotypes are no phenotypic analysis and limbs/digits/tail.

Disease Ontology: A cardiovascular system disease that primarily affects the blood vessels.⁶

Wikipedia: Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels.⁴⁴ more...

Aliases & Descriptions:

vascular disease 6 8 33 vascular diseases 17 32 23 43 arteriopathy 6 8

internal elastic lamina 6 arteriopathic disease 43 vascular anomaly 32

Diseases related to vascular disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 946)

id	Related Disease	Score	Top Affiliating Genes
1	peripheral vascular disease	38.0	VWF, SELE, SELP, SERPINE1, LPA, VCAM1
2	hyperhomocysteinemia	37.3	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
3	homocysteine	36.3	PIK3C2A, COG2, REN, RETN, VWF, SELE
4	type 2 diabetes mellitus	35.5	COG2, RECK, RETN, VWF, RBP4, SELE
5	pulmonary hypertension	35.0	SGCB, SETD2, BMPR2, FGA, ANGPT1, HTR1B
6	hypertension	34.6	PIK3C2A, LRP1, COG2, REN, RENBP, RETN
7	cadasil	33.9	COG2, REN, RETN, VWF, SELP, SERPINC1
8	renal vascular disease	33.7	VEGFA, MPV17, FBXL20, ALB, HSPA8, HSPD1
9	thrombophilia	33.4	VWF, SELE, SELP, SERPINC1, SERPINE1, MTRR
10	hypercholesterolemia	33.4	PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
11	atherosclerosis	33.3	ZNF202, PIK3C2A, LRP1, COG2, KLF2, RECK
12	cerebrovascular disease	32.8	COG2, RECK, REN, RETN, VWF, SELE
13	arteriosclerosis	32.2	COG2, SELE, SELP, SERPINE1, LPA, LPL
14	peripheral arterial occlusive disease	32.2	VWF, SELE, SELP, SERPINE1, VCAM1, CD40LG
15	diabetes mellitus	31.9	PIK3C2A, COG2, RECK, REN, RETN, SGCB
16	proteinuria	31.4	PIK3C2A, COG2, REN, RENBP, VWF, VTN
17	homocystinuria	31.4	SERPINC1, BHMT, MTRR, MTHFR, MTR, FBN1
18	arterial occlusive disease	31.1	VWF, SELE, SELP, VCAM1, MTHFR, CCL2
19	hyperlipidemia	31.0	PIK3C2A, LRP1, COG2, RETN, SGCB, VWF
20	insulin resistance	30.9	LRP1, COG2, REN, RETN, VWF, RBP4
21	thromboangiitis obliterans	30.8	SELE, SERPINE1, VCAM1, ICAM1, HTR2A, PLAT
22	cerebritis	30.8	PIK3C2A, LRP1, COG2, REN, SGCB, VWF
23	was-related disorders	30.7	REN, LPL, LIPC, CLEC4A, XDH, CETP
24	obesity	30.5	PIK3C2A, LRP1, COG2, RECK, REN, RETN
25	familial hypercholesterolemia	30.4	COG2, PCSK9, LPA, LPL, LIPC, LDLR
26	hyperglycemia	30.4	PIK3C2A, COG2, RETN, VWF, VTN, SELE
27	thrombosis	30.3	PIK3C2A, LRP1, COG2, RECK, REN, RETN
28	vascular malformations	30.2	VWF, VEGFA, MMP2, MMP9, FGF2, ENG
29	antiphospholipid syndrome	30.2	VWF, SELE, SELP, SERPINC1, SERPINE1, VKORC1
30	vascular dementia	29.8	VEGFA, LPA, MTHFR, APOE, NOTCH3, TGM2
31	spina bifida	29.7	BHMT, BHMT2, LEPR, MTRR, MTHFR, MTR
32	arteriovenous malformation	29.7	PIK3C2A, REN, VEGFA, VEGFB, KDR, MMP3
33	myocardial infarction	29.7	PIK3C2A, LRP1, COG2, RECK, REN, RETN
34	ischemia	29.5	PIK3C2A, COG2, REN, RETN, SGCB, VWF
35	mixed connective tissue disease	29.3	PIK3C2A, BMPR2, CD40LG, INS, IL6, FBN1
36	homocysteinemia	29.3	MTRR, MTHFR, MTR, FBN1, F5, CBS
37	neural tube defect	29.2	BHMT, LEPR, MTRR, MTHFR, MTR, CD40LG
38	cholesterol	29.0	ZNF202, PIK3C2A, LRP1, COG2, RECK, REN
39	aneurysm disease	28.9	LPA, MTHFR, MMP9, FBN1, NOS3, ACE
40	parkinson's disease	28.9	PARP1, MTR, GSR, IL15, APOE, AOC3
41	telangiectasis	28.8	BMP6, BMPR2, FBN1, ENG, ACVRL1, ELN
42	type 1 diabetes mellitus	28.6	RETN, RBP4, LPA, LIPC, BGLAP, LEPR
43	retinitis	28.2	PIK3C2A, LRP1, SGCB, VWF, VTN, RBP4
44	alcoholism	28.1	GSR, MAOA, HTR1B, HTR2A, HTR3A, HMGCR
45	nephropathy	28.1	LRP1, COG2, REN, RENBP, RETN, VWF
46	coronary arteriosclerosis	28.0	SELE, IL6, APOA1, APOB, APOE, CCL2
47	arthritis	27.8	MMP3, IL1A, IL6, TNF, TNFSF11, PLAUR
48	coronary heart disease	27.7	ZNF202, PIK3C2A, LRP1, COG2, RETN, VWF
49	lupus erythematosus	27.5	PIK3C2A, COG2, RECK, RETN, VWF, VTN
50	twinning	27.3	LRP1, COG2, REN, RETN, VWF, RBP4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to vascular disease:

²²

MGI Mouse Phenotypes related to vascular disease:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	INF	VEGFA, VCAM1, , CLEC4A, , LEPR
2	limbs/digits/tail phenotype	MP:0005371	INF	RECK, VEGFA, VCAN, LMNA, MTHFR,
3	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, , , REN, RENBP, RETN
4	cellular phenotype	MP:0005384	INF	, VWF, RBP4, SELE, SELP, VLDLR
5	growth/size phenotype	MP:0005378	INF	PIK3C2A, , , RECK, REN,
6	hematopoietic system phenotype	MP:0005397	INF	, BCL2L1, KCNN4, , P2RY1, P2RY12
7	reproductive system phenotype	MP:0005389	INF	REN, RBP4, VEGFA, LMNA, LIPC, LEPR
8	integument phenotype	MP:0010771	INF	RECK, SELP, RALBP1, , BCL2L1, LEPR
9	other phenotype	MP:0005395	INF	RECK, , LEPR, LDLR, CD40LG,
10	embryogenesis phenotype	MP:0005380	INF	, RECK, SERPINC1, , MYOCD, BMPR2
11	tumorigenesis	MP:0002006	INF	SERPINE1, BHMT, BCL2L1, LEPR, CDH13,
12	respiratory system phenotype	MP:0005388	INF	, , SELP, LPL, BMPR2, LEPR
13	endocrine/exocrine gland phenotype	MP:0005379	INF	KCNN4, LDLR, XDH, CD40LG, ITGA3, IL2
14	muscle phenotype	MP:0005369	INF	, , REN, , RBP4, VEGFA
15	vision/eye phenotype	MP:0005391	INF	RBP4, SELE, SELP, SERPINC1, VLDLR, VEGFA
16	skeleton phenotype	MP:0005390	INF	, , RECK, VEGFA, VCAN, LMNA
17	behavior/neurological phenotype	MP:0005386	INF	, REN, SELE, SELP, VLDLR,
18	normal phenotype	MP:0002873	INF	, , REN, , RBP4, SELE
19	nervous system phenotype	MP:0003631	INF	, RECK, REN, VWF, SELP, SERPINC1
20	digestive/alimentary phenotype	MP:0005381	INF	VWF, VEGFA, LMNA, KCNN4, LEPR, CD4
21	immune system phenotype	MP:0005387	INF	, , REN, , VWF, SELP
22	mortality/aging	MP:0010768	INF	PIK3C2A, , , RECK, REN, VWF
23	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, , RETN, SERPINE1, VLDLR, LPL
24	cardiovascular system phenotype	MP:0005385	INF	, , RECK, REN, , VWF
25	craniofacial phenotype	MP:0005382	INF	, , FBN1, IGF1R, CBS, HSPG2
26	liver/biliary system phenotype	MP:0005370	INF	, RECK, RETN, PCSK9, SERPINC1, VEGFA
27	renal/urinary system phenotype	MP:0005367	INF	REN, RENBP, SELP, LMNA, BHMT, LEPR

Articles related to vascular disease:

(show top 50)    (show all 407)

id	Title	Authors	Year	Affiliating Genes
1	LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma. (20436359)	HollA^ G.... MolnA!r J.M.	2010	LOXL1
2	Relationship of interleukin-6 with regional and globa l left-ventricular function in asymptomatic individuals without clinical cardio vascular disease: insights from the Multi-Ethnic Study of Atherosclerosis. (20064818)	Yan A.T.... Lima J.A.	2010	IL6
3	Visfatin, glucose metabolism and vascular disease: a review of evidence. (20346149)	Saddi-Rosa P.... Reis A.F.	2010	NAMPT
4	Association of the G894T polymorphism of the endothel ial nitric oxide synthase gene with diabetic foot syndrome foot ulcer, diabetic complications, and comorbid vascular diseases: a Turkish case-control study. (20642368)	Corapcioglu D.... Gedik V.T.	2010	NOS3
5	Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. (19168552)	Contois J.H.... Warnick G.R.	2009	APOB
6	TGF-beta and BMPR-II pharmacology--implications for p ulmonary vascular diseases. (19321386)	Upton P.D.... Morrell N.W.	2009	BMPR2
7	Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid? (18191647)	Avogaro A.... Fadini G.P.	2008	MAPK1, INS
8	Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease. (18310503)	Eugenin E.A.... Schecter A.D.	2008	CCR5
9	Endothelin--role in vascular disease. (18784133)	Abraham D.... Dashwood M.	2008	EDN1
10	Residual platelet thromboxane A2 and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease. (18221358)	Santos M.T.... Cosin J.	2008	PTGS1
11	Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. (18262190)	Polisecki E.... Schaefer E.J.	2008	PCSK9
12	The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. (19261978)	Jakubowski H.	2008	CBS, MARS, MTHFR
13	The metabolic syndrome and vascular disease in Asia. (17584042)	Cheung B.M.... Thomas G.N.	2007	INS
14	Markers of inflammation and prevalence of vascular disease in patients with metabolic syndrome. (18091698)	Novo G.... Novo S.	2007	CRP
15	Endothelial nitric oxide synthase in vascular disease: from marvel to menace. (16585403)	FAPrstermann U.... MA1nzel T.	2006	NOS3
16	Soluble bio-markers in vascular disease: much more than gauges of disease? (15810985)	Woollard K.J.	2005	SELP, CRP
17	Diabetic vascular disease: it's all the RAGE. (16356122)	Hudson B.I.... Schmidt A.M.	2005	AGER
18	Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease. (15823491)	Matsuzawa Y.	2005	ADIPOQ, INS
19	The effect of multi-factorial intervention on plasma von Willebrand factor, soluble E-selectin and tissue factor in diabetes mellitus: implications for atherosclerotic vascular disease. (15717870)	Lim H.S.... Lip G.Y.	2005	SELE
20	Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease. (14523602)	Sattler A.M.... Hofbauer L.C.	2004	TNFRSF11B, TNFRSF11A
21	Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor. (15033248)	Makin A.J.... Lip G.Y.	2004	VWF, F3
22	Cell cycle-related protein expression in Alzheimer's disease and vascular disease. (16191221)	Nagy Z.	2003	APOE
23	Endothelium derived relaxing factor and its effect on vascular disease (14650203)	Wang J.... Li Z.	2003	AHSP
24	Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. (12649347)	Marcus A.J.... Levi R.	2003	CD40LG, ENTPD1
25	Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1. (12624005)	Egashira K.	2003	CCL2
26	Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. (12819233)	Huang X.R.... Lan H.Y.	2003	ACE
27	Antioxidants and vascular diseases (12687797)	Matkovics A.	2003	AGTR1
28	Expression of angiogenesis and angiogenic factors in human aortic vascular disease. (12175973)	Kobayashi M.... Nimura Y.	2002	VEGFA
29	High-sensitivity C-reactive protein (CRP) assay--a novel method for assessment of risk ratios for atherosclerotic vascular diseases (11871134)	Takahashi H.	2002	CRP
30	Gene therapy targeting monocyte chemoattractant protein-1 for vascular disease. (12560586)	Kitamoto S.... Egashira K.	2002	CCL2
31	Can blood homocysteine explain the family history of vascular diseases? (11433886)	Reis R.P.... LuA-s A.S.	2001	CBS
32	Phospholipase A(2) in vascular disease. (11509445)	Hurt-Camejo E.... Kovanen P.	2001	PLA2G2A
33	Fluvastatin in combination with rad significantly red uces graft vascular disease in rat cardiac allografts. (11579289)	Gregory C.R.... Berryman E.R.	2001	HMGCR
34	Cardiac allograft vascular disease after orthotopic heart transplantation: methylenetetrahydrofolate reductase gene polymorphism C677T does not account for rapidly progressive forms. (10706059)	Pethig K.... Haverich A.	2000	MTHFR
35	Cytomegalovirus infection associated with immunosuppressive therapy in collagen vascular diseases (10614168)	Yoshihara S.... Masago R.	1999	PIK3C2A
36	Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study. (9609219)	Cushman M.... Tracy R.P.	1998	F5
37	Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease. (9753040)	Franco R.F.... Reitsma P.H.	1998	HFE
38	Activated protein C resistance in patients with perip heral vascular disease. (9786256)	Sampram E.S.... DahlbAock B.	1998	F5
39	Prevalence of renal artery stenosis in patients with peripheral vascular disease and hypertension. (8867560)	Wachtell K.... Lund J.O.	1996	ACE
40	A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. (7647779)	Frosst P.... Rozen R.	1995	MTHFR
41	Mortality risk by body weight and weight change in people with NIDDM. The WHO Multinational Study of Vascular Disease in Diabetes. (7555501)	Chaturvedi N.... Fuller J.H.	1995	INS
42	Antioxidants, von Willebrand factor and endothelial cell injury in hypercholesterolaemia and vascular disease. (7575774)	Blann A.D.... Miller J.P.	1995	VWF
43	Associations of urinary albumin excretion rate with vascular disease in europid nondiabetic subjects. (8086657)	Gould M.M.... Haines A.P.	1994	ALB
44	The prevalence of peripheral vascular disease in type 2 diabetic patients with and without proteinuria. (7822899)	Migdalis I.N.... Samartzis M.	1994	ALB
45	Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of 'syndrome X'. (8507440)	Resnick L.M.	1993	INS
46	Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. (8364016)	Fryer R.H.... Rodgers G.M.	1993	F3
47	Simultaneous detection of the platelet aggregation and release in patients with cardio-cerebral vascular diseases associated with blood stasis and their clinical significance (1832339)	Han X.M.... Mao H.M.	1991	PPBP
48	Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: implications for vascular disease in hyperinsulinemic states. (1719559)	Schneider D.J.... Sobel B.E.	1991	SERPINE1, IGF1, INS
49	Insulin as risk factor for vascular disease. (2190779)	Gwinup G.... Elias A.N.	1990	INS
50	Immunological abnormalities in a group of patients with limited cutaneous systemic sclerosis and prominent vascular disease. (2104177)	Passaleva A.... Ricci M.	1990	APOH

Genes related to vascular disease according to GeneCards:

(show top 50)    (show all 234)

id	Symbol	Description	Score	GeneCards Section Context
1	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.1	Publications, Summaries, Functions, UniProt Related
2	CST3	cystatin C	11.0	Publications, Summaries
3	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
4	VEGFA	vascular endothelial growth factor A	11.0	Publications
5	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
6	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
7	SELE	selectin E	11.0	Publications
8	LPA	lipoprotein, Lp(a)	11.0	Publications
9	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
10	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
11	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
12	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
13	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
14	APOA1	apolipoprotein A-I	11.0	Publications
15	VWF	von Willebrand factor	11.0	Publications
16	ALB	albumin	11.0	Publications
17	BHMT2	betaine--homocysteine S-methyltransferase 2	11.0	Summaries
18	PON2	paraoxonase 2	11.0	Summaries
19	TRPM8	transient receptor potential cation channel, subfamily M, member 8	11.0	Summaries
20	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
21	CTGF	connective tissue growth factor	11.0	Publications
22	PF4	platelet factor 4	11.0	Publications
23	HSPA8	heat shock 70kDa protein 8	11.0	Publications
24	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
25	CRP	C-reactive protein, pentraxin-related	11.0	Publications
26	THBD	thrombomodulin	11.0	Publications
27	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
28	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
29	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
30	KNG1	kininogen 1	11.0	Publications
31	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
32	PLAT	plasminogen activator, tissue	11.0	Publications
33	INS	insulin	11.0	Publications
34	ICAM1	intercellular adhesion molecule 1	11.0	Publications
35	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
36	KLK15	kallikrein-related peptidase 15	11.0	Publications
37	CBS	cystathionine-beta-synthase	11.0	Publications
38	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
39	AHSP	alpha hemoglobin stabilizing protein	11.0	Publications
40	MGP	matrix Gla protein	11.0	Publications
41	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	11.0	Publications
42	NOX1	NADPH oxidase 1	11.0	Publications
43	PLTP	phospholipid transfer protein	11.0	Publications
44	APOA2	apolipoprotein A-II	11.0	Publications
45	MMRN1	multimerin 1	11.0	Publications
46	FGB	fibrinogen beta chain	11.0	Publications
47	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	11.0	Publications
48	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.0	Publications
49	NPPC	natriuretic peptide C	11.0	Publications
50	APOC2	apolipoprotein C-II	11.0	Publications

Pathways related to vascular disease according to GeneDecks:

(show top 50)    (show all 118)

id	Pathway	Score	Top Affiliating Genes
1	MAPK Signaling36	INF	, BMP6, , LAMB1, LAMB2,
2	Glioma Invasiveness36	INF	, , BMP6, ITGA2B, ITGA3, ITGAM
3	JAK-STAT Pathway36	INF	, BMP6, , , CD4,
4	MAPK Family Pathway36	INF	, BMP6, , , CD4,
5	Antioxidant Action of Vitamin-C36	INF	, BMP6, BMPR2, , , CD4
6	Akt Signaling36	INF	, BMPR2, CD4, ITGA2, ITGA2B, ITGAM
7	all-trans-Retinoic Acid Signaling in Brain36	INF	BMP6, IL10, IL15, IL18, IL1A, IL2
8	DHA Signaling36	INF	, BMP6, , BCL2L1, , FGF2
9	ERK Signaling36	INF	, BMP6, LAMB1, LAMB2, ITGA2B, ITGA3
10	Rheumatoid arthritis20	INF	VEGFA, , , MMP3, IL15, IL18
11	MIF Mediated Glucocorticoid Regulation36	INF	BMP6, IL10, IL15, IL18, IL1A, IL2
12	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	INF	BGLAP, , IL1A, IL6, APOE, FASLG
13	PTEN Pathway36	INF	, , LAMB1, LAMB2, ITGA2, ITGA2B
14	p38 Signaling36	INF	, BMP6, BMPR2, , CD4,
15	PPAR Pathway36	INF	, ITGA2, ITGA2B, ITGA3, ITGAM,
16	STAT3 Pathway36	INF	BMP6, BMPR2, CD4, IL10, IL10RA, IL15
17	Tec Kinases Signaling36	INF	, BMP6, BMPR2, CD4, ITGA2, ITGA2B
18	Rho Family GTPases36	INF	, BMP6, , LAMB1, LAMB2,
19	Statin Pathway, Pharmacodynamics34	INF	, LPL, LIPC, LDLR, LCAT, APOA1
20	p70S6K Signaling36	INF	, BMP6, , , INS, FGF2
21	PEDF Induced Signaling36	INF	BMP6, BCL2L1, IL10, IL15, IL18, IL1A
22	MIF Regulation of Innate Immune Cells36	INF	BMP6, , IL10, IL15, IL18, IL1A
23	PAK Pathway36	INF	, BMP6, , , FGF2, IL10
24	Angiogenesis3	INF	RECK, REN, , , , ITGB3
25	Actin-Based Motility by Rho Family GTPases36	INF	ITGA2B, ITGAM, , IL2, IGF1, CTGF
26	Rac1 Pathway36	INF	, BMP6, , , ITGA2, ITGA2B
27	Phospholipase-C Pathway36	INF	, BMP6, , LAMB1, LAMB2, CD79A
28	Molecular Mechanisms of Cancer36	INF	BMP6, BMPR2, , BCL2L1, LAMB2,
29	p53 Mediated Apoptosis36	INF	, BMP6, , , FGF2, IL2
30	Ras Pathway36	INF	, RALBP1, , , ITGA2, ITGA2B
31	Pancreatic Adenocarcinoma36	INF	, BMP6, , BCL2L1, MMP2, MMP3
32	Apoptotic Pathways in Synovial Fibroblasts36	INF	, BMP6, , , FGF2, IL2
33	Cellular Apoptosis Pathway36	INF	, BMP6, , BCL2L1, , FGF2
34	TGF-Beta Pathway36	INF	, BMP6, , , CD4,
35	Renin-Angiotensin Pathway36	INF	REN, , VCAM1, BMP6, ,
36	Blood Coagulation Signaling Pathways37	INF	VWF, SERPINC1, SERPINE1, FGB, GP1BA, GP6
37	Cell adhesion_ECM remodeling41	INF	, SERPINE1, VCAN, LAMB1, ,
38	UPA-UPAR Pathway36	INF	, SERPINE1, LAMB1, LAMB2, , ITGA2
39	Endothelin-1 Signaling Pathway36	INF	BMP6, IL10, IL18, IL1A, IL2, IL4
40	Malaria20	INF	, SELE, SELP, VCAM1, CD40LG, CD40
41	IL-6 Pathway36	INF	BMP6, IL10, IL18, IL4, , ANGPT1
42	Cytokine-cytokine receptor interaction20	INF	VEGFA, , BMPR2, , LEPR, CD40LG
43	Mitochondrial Apoptosis36	INF	, BMP6, , BCL2L1, , FGF2
44	Complement and coagulation cascades20	INF	VWF, SERPINC1, SERPINE1, , FGA, FGB
45	ILK Signaling36	INF	, , LAMB1, LAMB2, , CDH13
46	Cell adhesion ECM remodeling10	INF	, SERPINE1, VCAN, LAMB1, ,
47	Chagas disease (American trypanosomiasis)20	INF	SERPINE1, , IL10, IL2, IL6, FASLG
48	Selected targets of HNF110	INF	LPA, INS, APOA1, APOA2, APOB, APOH
49	Pathways in cancer20	INF	VEGFA, , RALBP1, BCL2L1, LAMB1, LAMB2
50	Toxoplasmosis20	INF	BCL2L1, LDLR, LAMB1, LAMB2, CD40LG, CD40

Compounds related to vascular disease according to GeneDecks:

(show top 50)    (show all 560)

id	Compound	Score	Top Affiliating Genes
1	glucose32	INF	, VCAN, , LAMB1, ITGA2, GZMB
2	atp32	INF	ZNF202, PIK3C2A, RECK, RENBP, ,
3	pge132	INF	PIK3C2A, VWF, SERPINE1, LCAT, P2RY1, P2RY12
4	fmlp32	INF	SELP, VCAM1, MPO, ITGAM, , IL1A
5	choline32 9 18 9	INF	PIK3C2A, BHMT, LEPR, MTHFR, GRP, APOA1
6	glutamine32	INF	VWF, , , LPL, BMP6, LEPR
7	silymarin32	INF	VEGFA, BMP6, , XDH, , MMP2
8	5fluorouracil32	INF	SELE, VEGFA, , BCL2L1, MTHFR, MPO
9	procollagen32	INF	BMP6, CMA1, BGLAP, P4HB, , MMP2
10	c2ceramide32	INF	, BCL2L1, , CASP8, , TNF
11	paraffin32	INF	VWF, VEGFA, VCAM1, CMA1, BGLAP,
12	dopamine32 9 18 9	INF	REN, RBP4, SELE, BMP6, LEPR, MTHFR
13	estradiol32 9 18 9	INF	REN, SERPINE1, LEPR, P4HB, ,
14	s-nitroso-n-acetylpenicillamine32	INF	, , XDH, ANXA5, IFNG, CAT
15	matrigel32	INF	, VWF, , SELE, SERPINE1,
16	actinomycin d32	INF	RETN, SELE, , SERPINE1, VEGFA, LPA
17	agar32	INF	CD40LG, , FGF2, GRP, , IGF1R
18	valsartan32 42 9 9	INF	REN, SELP, SERPINE1, CCL2, ALB, CYP2C9
19	lactate32	INF	PIK3C2A, RECK, VWF, , , RBP4
20	pioglitazone32 9 9	INF	COG2, RETN, RBP4, , NAMPT, VEGFA
21	urea32 9 18 9	INF	PIK3C2A, RETN, , LPA, P4HB,
22	cholesterol32 9 18 9	INF	ZNF202, PIK3C2A, , COG2, RECK, REN
23	prostaglandin f2alpha32	INF	SERPINE1, LPL, GRP, IL1A, IGF1R, IGF1
24	ibmx32	INF	, LPL, VCAM1, MMP2, INS, FGF2
25	hirudin32	11.0	SERPINC1, FGA, FGB, GP1BA, F5, PLAUR
26	ramipril32 9 9	12.9	REN, SERPINE1, CD79A, INS, ALB, HMGCR
27	il 1032	5.9	BMP6, CD40, IL10, IL10RA, IL15, IL18
28	polysulfone32	INF	VWF, SELP, VCAM1, ITGAM, FGA, IL1RAPL2
29	glycosaminoglycan32	INF	, , SERPINC1, VCAN, , FGF2
30	2-deoxyglucose32	INF	INS, GRP, ANXA5, IGF1, CANT1,
31	bleomycin32 9 9	INF	FGF2, IL4, CCL2, IGF1, , HSPD1
32	mevalonate32	INF	SERPINE1, VCAM1, BCL2L1, LDLR, CD40, ITGAM
33	nitric oxide32 9 18 9	INF	COG2, , REN, RETN, ,
34	superoxide32 18	INF	PIK3C2A, , , LPA, VCAM1, LIPC
35	triacylglycerol32	INF	COG2, RBP4, SERPINE1, VLDLR, LPL,
36	calcitriol32 42 9 18 9	INF	REN, BMP6, BGLAP, , ITGAM,
37	telmisartan32 9 9	INF	COG2, REN, INS, ALB, PPARG,
38	calcium32 9 18 9	INF	PIK3C2A, , COG2, RECK, REN, RETN
39	12-o-tetradecanoylphorbol 13-acetate32	INF	BMP6, CD4, ITGA2, ITGA2B, ITGAM,
40	gsno32	INF	, SELP, , P4HB, XDH,
41	ivig32	INF	PIK3C2A, VWF, IL1RAPL2, FASLG, CCR5, F8
42	gm-csf32	INF	VEGFA, BMP6, BCL2L1, IL10, IL15, IL18
43	nicotine32 34 9 9	INF	GRP, CYP2C9,
44	adp32 18	INF	PIK3C2A, RECK, RETN, VWF, , SELP
45	nitroglycerin32 9 9	INF	COG2, , TNFRSF11B, ,
46	4-hydroxynonenal32 18	INF	RALBP1, , LCAT, XDH, MPO,
47	creatinine32	INF	REN, RETN, VWF, RBP4, SELE, SELP
48	ribavirin32 34 9 9	INF	CD40LG, MMP2, MMP9, IL10, IL18, IL2
49	thapsigargin32 42	INF	, SERPINE1, BCL2L1, , GRP, IL2
50	aminoguanidine32 9 9	INF	APOB, , IFNG, ALB, HSPA1A,

Cellular components related to vascular disease according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	INF	, CXCR3, CXCL12, TLR4, ACE, FGA
2	integral to plasma membrane	GO:005887	INF	, , SELP, BMPR2, CLEC4A, GP1BA
3	extracellular region	GO:005576	INF	, PLAUR, PLTP, PLG, ,
4	cell surface	GO:009986	INF	VEGFA, LPL, VCAM1, BMPR2, LDLR, P4HB
5	platelet alpha granule lumen	GO:031093	INF	IGF1, F8, F5, ALB, F13A1, PPBP
6	extracellular space	GO:005615	INF	REN, , , PCSK9, RBP4, SELE
7	membrane raft	GO:045121	INF	TNF, , , , ACE2, TLR4
8	extracellular matrix	GO:031012	INF	VWF, , SERPINE1, LPL, VCAN, CMA1
9	high-density lipoprotein particle	GO:034364	INF	PON1, APOH, APOE, , APOA2, APOA1
10	caveola	GO:005901	INF	NOS3, DLC1, PTGS2, , HMOX1,
11	very-low-density lipoprotein particle	GO:034361	INF	APOH, APOE, APOC2, APOB, , APOA2
12	plasma membrane	GO:005886	INF	, , CX3CR1, CXCR3, SOD1, CSF1
13	chylomicron	GO:042627	INF	APOE, APOC2, APOB, , APOA2, LPL

Biological processes related to vascular disease according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of NF-kappaB transcription factor activity	GO:051092	INF	CD40, INS, IL6, ICAM1, CAT, TNF
2	extracellular matrix disassembly	GO:022617	INF	CMA1, , MMP2, MMP3, MMP9,
3	lipid metabolic process	GO:006629	INF	ZNF202, LPA, LPL, , LDLR, LCAT
4	response to hypoxia	GO:001666	INF	VEGFA, VCAM1, MYOCD, MMP9, IL18, IL1A
5	inflammatory response	GO:006954	INF	SELE, SELP, BMP6, MS4A2, CD40LG, CD40
6	cholesterol metabolic process	GO:008203	INF	PCSK9, VLDLR, LIPC, LEPR, LDLR, LCAT
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, SERPINE1, VEGFA, MYOCD, BMP6,
8	regulation of blood pressure	GO:008217	INF	REN, RENBP, ATP1A2, HMOX1, PTGS2, PTGS1
9	aging	GO:007568	INF	VCAM1, P2RY1, , IL15, FAS, CCL2
10	response to estrogen stimulus	GO:043627	INF	SERPINE1, BGLAP, APOA2, FAS, ANGPT1,
11	positive regulation of cell migration	GO:030335	INF	VEGFA, , LAMB1, , CDH13,
12	positive regulation of protein kinase B signaling cascade	GO:051897	INF	, INS, ANGPT1, IGF1, , F3
13	low-density lipoprotein particle remodeling	GO:034374	INF	LIPC, CETP, MPO, APOA2, APOB,
14	cholesterol homeostasis	GO:042632	INF	PCSK9, , LIPC, LDLR, LCAT, CETP
15	response to drug	GO:042493	INF	REN, VLDLR, LPL, BGLAP, ,
16	leukocyte migration	GO:050900	INF	SELP, , ITGA3, ITGAM, , ITGB3
17	response to glucocorticoid stimulus	GO:051384	INF	SERPINE1, BGLAP, LCAT, IL10, IL6, APOA2
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	, VEGFA, , CD4, , ITGB3
19	positive regulation of MAP kinase activity	GO:043406	INF	VEGFA, CD40, HTR2A, TNF, TNFSF11,
20	angiogenesis	GO:001525	INF	, SERPINE1, VEGFA, , ,
21	positive regulation of inflammatory response	GO:050729	INF	SERPINE1, IL15, IL18, IL2, , PLA2G2A
22	positive regulation of smooth muscle cell proliferation	GO:048661	INF	, , CDH13, IL6, IGF1, HMOX1
23	positive regulation of protein phosphorylation	GO:001934	INF	VEGFA, P2RY1, CD40, ITGB3, , F2
24	lipoprotein metabolic process	GO:042157	INF	PCSK9, LPA, LPL, LDLR, LCAT, P4HB
25	positive regulation of apoptotic process	GO:043065	INF	, MMP9, FASLG, FAS, ANXA5, ALOX12
26	platelet activation	GO:030168	INF	VWF, SELP, SERPINE1, VEGFA, , P2RY1
27	blood coagulation	GO:007596	INF	VWF, SELP, SERPINC1, SERPINE1, , VEGFA
28	response to lipopolysaccharide	GO:032496	INF	SELE, SELP, , MMP9, IL18BP, IL1A
29	reverse cholesterol transport	GO:043691	INF	, LIPC, LCAT, CETP, APOA1, APOA2
30	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	INF	SELP, , INS, ANGPT1, IGF1, F2
31	positive regulation of cell proliferation	GO:008284	INF	NAMPT, VEGFA, MYOCD, , BCL2L1,
32	negative regulation of cell proliferation	GO:008285	INF	MYOCD, , CDH13, , FGF2, IL1A
33	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	, , P2RY1, FGF2, IL1A, ANGPT1
34	response to mechanical stimulus	GO:009612	INF	BGLAP, P2RY1, , MMP9, MGP,
35	signal transduction	GO:007165	INF	VLDLR, NAMPT, RALBP1, CD4, FGA, FGB
36	positive regulation of cellular protein metabolic process	GO:032270	INF	INS, , , NR1H3, NFKBIA,
37	regulation of vasoconstriction	GO:019229	INF	ATP1A2, EDN1, , , ACE, ACE2
38	negative regulation of apoptotic process	GO:043066	INF	SERPINE1, VEGFA, , BCL2L1, INS, IL4
39	positive regulation of cholesterol efflux	GO:010875	INF	, APOE, , NR1H3, NFKBIA,
40	positive regulation of endothelial cell proliferation	GO:001938	INF	VEGFA, , BMP6, BMPR2, ,
41	positive regulation of angiogenesis	GO:045766	INF	SERPINE1, VEGFA, , MMP9, FGF2, IL1A
42	platelet degranulation	GO:002576	INF	VWF, SELP, SERPINE1, VEGFA, , ITGA2B
43	positive regulation of endothelial cell migration	GO:010595	INF	VEGFA, BMPR2, , ITGB3, ANGPT1, ALOX12
44	anti-apoptosis	GO:006916	INF	, BCL2L1, MPO, CD40LG, IL10, IL1A
45	extracellular matrix organization	GO:030198	INF	RECK, CMA1, P4HB, , MMP2, MMP3
46	cell adhesion	GO:007155	INF	VWF, , SELP, VCAM1, VCAN, CLEC4A
47	cellular response to lipopolysaccharide	GO:071222	INF	SERPINE1, VLDLR, IL10, CCL2, CCR5, IFNG
48	small molecule metabolic process	GO:044281	INF	PIK3C2A, , NAMPT, LPA, LPL, VCAN
49	negative regulation of macrophage derived foam cell differentiation	GO:010745	INF	CETP, ITGB3, PPARG, , , NR1H3
50	very-low-density lipoprotein particle remodeling	GO:034372	INF	LPL, LIPC, LCAT, CETP, , APOC2

Molecular functions related to vascular disease according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	apolipoprotein binding	GO:034185	INF	, PLG, LIPC, LPA, VLDLR, PCSK9
2	heme binding	GO:020037	INF	CYP2C9, NOS1, NOS2, NOS3, ,
3	eukaryotic cell surface binding	GO:043499	INF	EPO, ADIPOQ, TGFB1, , ,
4	cholesterol transporter activity	GO:017127	INF	, APOB, , APOA2, APOA1, CETP
5	growth factor activity	GO:008083	INF	IL4, IL2, IL10, FGF2, BMP6,
6	protein heterodimerization activity	GO:046982	INF	, NR1H3, PDGFA, , ABCG8, AGTR1
7	receptor activity	GO:004872	INF	NPR2, IL10RA, ITGB3, , , CD40
8	protein homodimerization activity	GO:042803	INF	NPPC, PON1, CSF1, SOD1, ,
9	heparin binding	GO:008201	INF	NRP1, CTGF, , CCL2, APOH, APOE
10	protein binding	GO:005515	INF	GAPDH, , EPO, ADIPOQ, ADAMTS13, PECAM1
11	integrin binding	GO:005178	INF	ICAM1, , CTGF, , ADAMTS13, IGF1
12	cytokine activity	GO:005125	INF	IFNG, FASLG, IL6, IL4, IL2, IL1A
13	transmembrane signaling receptor activity	GO:004888	INF	ICAM1, TNFRSF11A, AGER, TLR4, THBD, NPR2
14	receptor binding	GO:005102	INF	, , TNC, CRAT, NOS2,
15	glycoprotein binding	GO:001948	INF	ACE2, , APOH, , , ITGAM
16	copper ion binding	GO:005507	INF	CP, SOD1, TP53, ALB, F5, F8
17	enzyme binding	GO:019899	INF	, , CAT, CBS, APOB, APOA1