MCID: VSC007
MIFTS: 70

Vascular Disease malady

Mental diseases, Gastrointestinal diseases, Cardiovascular diseases categories
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Summaries for Vascular Disease

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MedlinePlus:33 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards based summary: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and homocysteinemia. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are A-beta Plaque Formation and APP Metabolism and Cell adhesion ECM remodeling. The compounds gliclazide and fosinopril have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.

Wikipedia:65 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Aliases & Classifications for Vascular Disease

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Related Diseases for Vascular Disease

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Diseases related to Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 451)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.9SELE, SELP, VCAM1, MTHFR
2homocysteinemia31.0MTHFR
3systemic lupus erythematosus31.0CRP
4renal artery disease30.7ALB, ACE
5arteriosclerosis30.6MTHFR, VCAM1, SERPINE1
6systemic scleroderma30.5ACE
7ischemia30.5CST3, SELP, SELE, VEGFA
8eclampsia30.5MTHFR
9dementia30.5AGER, CST3, CETP
10thromboembolism30.5SERPINE1, SELP, MTHFR
11arthritis30.4AGER, CRP, ALB, SELE
12central retinal vein occlusion30.4VEGFA, MTHFR
13retinal vein occlusion30.3VEGFA, MTHFR
14connective tissue disease30.3SELE, VCAM1, ALB
15carotid stenosis30.3SELP, CRP
16peritonitis30.3CRP, ALB, SELP
17antiphospholipid syndrome30.3MTHFR, VCAM1, SELP, SELE
18vascular dementia30.3VEGFA, MTHFR, CST3
19collagen disease30.3CRP
20type 1 diabetes mellitus30.2ALB, CST3, ACE, CETP
21alzheimer's disease30.2PPBP, PON2, CETP, CST3, AGER
22diabetic angiopathy30.2SELE, AGER
23diabetic nephropathy30.1SERPINE1, PON2, MTHFR, ACE, CST3, ALB
24polycystic ovary syndrome30.1SERPINE1, CRP, AGER
25arteriosclerosis obliterans30.0SELP, VCAM1
26hypertension30.0ALB, CRP, PPBP, SERPINE1, SELE, VCAM1
27nephritis30.0ALB, ACE, VCAM1
28chronic obstructive pulmonary disease29.9SFTPD, CRP
29uremia29.9VCAM1, ALB, CRP, AGER
30pancreatitis29.8CRP, ALB, SELP
31thrombophilia29.8PPBP, SERPINE1, SELE, SELP, MTHFR
32kawasaki disease29.8CRP, SELE
33hyperhomocysteinemia29.8VCAM1, MTHFR, CST3, ALB, CRP, SELP
34cerebrovascular disease29.8SELP, CETP, MTHFR, ACE, CST3
35congenital heart disease29.7CST3, ACE, CETP, PPBP
36hypertriglyceridemia29.7APOA2, SERPINE1, SELE, VCAM1, CETP
37thrombocytopenia29.7ALB, SELP, PPBP
38thrombocytosis29.6PPBP, SELP, CRP
39venous thrombosis29.6FGB, MTHFR, CETP, SELP, SERPINE1
40vasculitis29.6PPBP, SELE, SELP, VCAM1, ALB, CRP
41inflammatory bowel disease29.5SELE, SELP, VCAM1, CRP
42obesity29.5SFTPD, APOA2, SERPINE1, SELE, CETP, CRP
43hyperglycemia29.4SERPINE1, SELE, VCAM1, CETP, ACE, ALB
44insulin resistance29.4APOA2, SERPINE1, SELE, VCAM1, CETP, ACE
45proteinuria29.3VEGFA, APOA2, CETP, ACE, CST3, ALB
46breast cancer29.3PPBP, VEGFA, SERPINE1, MTHFR, CST3, ALB
47melanoma29.2AGER, CST3, VCAM1, VEGFA, PPBP
48essential hypertension29.2PPBP, SERPINE1, SELP, CETP, ACE, CST3
49diabetes mellitus29.1MTHFR, ACE, CST3, ALB, CRP, AGER
50asthma29.0CETP, VCAM1, SELE, SFTPD, PPBP

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Symptoms for Vascular Disease

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Drugs & Therapeutics for Vascular Disease

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Drug clinical trials:

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Genetic Tests for Vascular Disease

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Anatomical Context for Vascular Disease

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MalaCards organs/tissues related to Vascular Disease:

32
Heart, Endothelial, Brain, Kidney, Spinal cord, Bone, Smooth muscle, Skin, Lung, Monocytes, Retina, Pancreas, Testes, Skeletal muscle, Liver, Bone marrow, Ovary, Pons, Neutrophil, Eye, Whole blood, Lymph node, Cortex, Colon, Adipocyte, Breast, Prostate, Myeloid, Nk cells, B cells

Animal Models for Vascular Disease or affiliated genes

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Publications for Vascular Disease

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Articles related to Vascular Disease:

(show top 50)    (show all 1581)
idTitleAuthorsYear
1
Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study. (24430876)
2014
2
Extracellular vesicle-derived CD14 is independently associated with the extent of cardiovascular disease burden in patients with manifest vascular disease. (24398371)
2014
3
Diabetes mellitus and peripheral vascular disease: diagnosis and management. (24296015)
2014
4
Same-day discharge after angioplasty for peripheral vascular disease: is it a safe and feasible option? (25131758)
2014
5
Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (25351520)
2014
6
Bioreactors as engineering support to treat cardiac muscle and vascular disease. (23965594)
2013
7
Impact of Smoking on Long-Term Outcomes in Patients with Atherosclerotic Vascular Disease Treated with Aspirin or Clopidogrel: Insights from the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) Trial. (24239662)
2013
8
Impact of estimated glomerular filtration rate on vascular disease extent and adverse cardiovascular events in patients without chronic kidney disease. (23317678)
2013
9
Relation between aortic valve sclerosis and ankle-brachial index in participants clinically free of atherosclerotic vascular disease. (23267238)
2013
10
Peripheral vascular disease as remote ischemic preconditioning, for acute stroke. (23958050)
2013
11
Mitochondria in vascular disease. (22392270)
2012
12
Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease. (22272893)
2012
13
The risk of general and abdominal adiposity in the occurrence of new vascular events and mortality in patients with various manifestations of vascular disease. (21712810)
2012
14
Initial experience with the 5 A9 300-mm Proteus embolic capture angioplasty balloon in the treatment of peripheral vascular disease. (23210883)
2012
15
Pretreatment of endothelial progenitor cells with osteopontin enhances cell therapy for peripheral vascular disease. (22304991)
2012
16
Polycystic ovary syndrome: a common endocrine disorder and risk factor for vascular disease. (21562798)
2011
17
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. (21069462)
2011
18
An option for intraoperative placement of an intra-aortic balloon pump in patients with occlusive peripheral vascular disease. (20633901)
2011
19
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
20
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
21
The influence of basic ventilation strategies on cerebral oxygenation in anesthetized patients without vascular disease. (21061050)
2010
22
Non-invasive imaging of diabetic vascular disease. (21154315)
2010
23
The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease. (19724159)
2009
24
Versican degradation and vascular disease. (16839865)
2006
25
Percutaneous continuous aortic flow augmentation for cardiac recovery in a chronic heart failure patient with peripheral vascular disease. (17170590)
2006
26
Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped. (15654296)
2005
27
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (15051034)
2004
28
Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. (14998419)
2004
29
RHO SIGNALING in vascular diseases. (15616164)
2004
30
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. (12777673)
2003
31
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. (12805074)
2003
32
Effects of cilostazol on serum lipid concentrations and plasma fatty acid composition in type 2 diabetic patients with peripheral vascular disease. (12624709)
2003
33
MR angiography for assessment of peripheral vascular disease. (12171187)
2002
34
Ethnic differences in peripheral vascular disease. (12425370)
2002
35
ABC of arterial and vascular disease. Secondary prevention of peripheral vascular disease. (10797042)
2000
36
ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients. (11124487)
2000
37
Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation. (10638832)
1999
38
Is clopidogrel markedly superior to aspirin in patients with peripheral vascular disease? (16793749)
1998
39
Renal vascular disease in the elderly. (9839288)
1998
40
Homocysteinemia: new information about an old risk factor for vascular disease. (10537928)
1998
41
Von Willebrand factor and soluble E-selectin in hyperlipidaemia: relationship to lipids and vascular disease. (9136912)
1997
42
Vascular permeability/vascular endothelial growth factors: a potential role in the pathogenesis and treatment of vascular diseases. (9552580)
1996
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. (8281664)
1994
45
Semiconductor diode laser photocoagulation in retinal vascular disease. (2255529)
1990
46
The tunable dye laser in the management of retinal vascular disease. (3229908)
1988
47
Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease. (3680515)
1987
48
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
49
Photocoagulation of retinal vascular disease. (4507180)
1972
50
Linear scleroderma with hemiatrophy: report of three cases associated with collagen-vascular disease. (5907143)
1966

Variations for Vascular Disease

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Expression for genes affiliated with Vascular Disease

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Expression patterns in normal tissues for genes affiliated with Vascular Disease

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Pathways for genes affiliated with Vascular Disease

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Compounds for genes affiliated with Vascular Disease

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Compounds related to Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1gliclazide44 50 1111.7VEGFA, SELE, VCAM1, ALB
2fosinopril44 1110.7SERPINE1, ACE, ALB, CRP
3telmisartan44 28 1111.6ACE, ALB, AGER, CRP
4hydrochlorothiazide44 28 50 24 1113.5ALB, SERPINE1, ACE, CRP
5ramipril44 1110.5SERPINE1, CST3, ALB, CRP, ACE
6kininogen449.5ALB, SERPINE1, CST3, SELP, ACE
7carvedilol44 50 28 1112.5ACE, SELE, VEGFA, VCAM1
8amlodipine44 50 24 1112.5VCAM1, SERPINE1, ACE, ALB
9perindopril44 50 1111.5SERPINE1, VEGFA, CRP, ALB, ACE
10metformin44 50 1111.4MTHFR, CRP, AGER, ACE, SERPINE1
11valsartan44 61 28 1112.4ACE, CRP, SELP, SERPINE1, ALB
12candesartan44 50 28 1112.3SERPINE1, SELP, ACE, VEGFA, ALB, AGER
13quinapril44 50 1111.3SERPINE1, SELE, SELP, ACE, CRP
14uric acid44 2410.3AGER, ALB, SERPINE1, CRP, CST3, MTHFR
15sele449.3SELP, VCAM1, ACE, CETP, SELE, MTHFR
16iohexol449.2CST3, SELP, PPBP, ALB
17alpha tocopherol449.2CETP, MTHFR, CRP, ALB, VCAM1
18folate449.2CRP, ALB, CST3, MTHFR, VCAM1, SELE
19methotrexate50 44 1111.1SERPINE1, ALB, CRP, SELE, CST3, MTHFR
208-isoprostane449.1CRP, VCAM1, SERPINE1, SELE
21cyclophosphamide44 50 1111.1SELE, VCAM1, CRP, VEGFA, MTHFR, SERPINE1
22warfarin44 50 24 1112.0SELP, MTHFR, PPBP, ALB, ACE
23n acetylcysteine448.8CRP, CST3, VCAM1, SELP, SELE, VEGFA
24mannitol44 119.8CRP, SERPINE1, VCAM1, SELP, ALB
25losartan44 50 28 1111.8SELP, SERPINE1, VCAM1, ACE, ALB, CRP
26fluvastatin44 50 28 1111.7VCAM1, CRP, ACE, CETP, SERPINE1, SELE
27simvastatin44 50 61 28 24 1113.7VEGFA, SERPINE1, CETP, CRP, SELE, VCAM1
28fenofibrate44 50 1110.6CRP, VCAM1, SELP, SERPINE1, APOA2, SELE
29rosiglitazone28 44 50 24 1112.6CRP, SERPINE1, SELE, VCAM1, ALB
30iloprost61 28 44 1111.6SELE, SELP, VCAM1, PPBP
31polysulfone448.5SELP, CRP, ALB, VCAM1, PPBP, CST3
32pravastatin44 50 28 24 1112.5SELE, SERPINE1, SELP, CETP, MTHFR, ACE
33atorvastatin44 50 28 24 1112.5SELP, VEGFA, CRP, ACE, CETP, VCAM1
34testosterone44 61 24 1111.5KLK15, ALB, SERPINE1, SELE, VCAM1, MTHFR
35aspartate448.3CETP, CST3, MTHFR, ALB, CRP, SELE
36aspirin44 50 28 2411.0PPBP, ACE, SERPINE1, SELE, SELP, CETP
37alanine447.8PPBP, SELE, VCAM1, CRP, ALB, CST3
38homocysteine44 248.8VCAM1, SELP, CETP, BHMT2, CRP, ALB
39lactate447.8CRP, CST3, SELE, SFTPD, PPBP, ALB
40prostacyclin447.7AGER, CRP, VCAM1, SELP, SELE, SERPINE1
41creatinine447.7ACE, MTHFR, SELP, SELE, SERPINE1, ALB
42vegf447.7SELE, VCAM1, AGER, CRP, CST3, SELP
43nitric oxide44 24 119.7SFTPD, SELE, VCAM1, ACE, AGER, SELP
44fibrinogen447.3PPBP, APOA2, SERPINE1, SELE, SELP, VCAM1
45cysteine447.2ALB, CST3, PPBP, SELP, VCAM1, CETP
46heparin44 28 24 1110.1PPBP, VEGFA, APOA2, SERPINE1, SELE, SELP
47lipid446.6ACE, CETP, VCAM1, PON2, SELE, SERPINE1
48glucose446.6VCAM1, PON2, ACE, PPBP, APOA2, SFTPD
49serine446.3SERPINE1, PPBP, VCAM1, CETP, MTHFR, RARRES2
50cholesterol44 28 24 119.1PPBP, SFTPD, APOA2, SERPINE1, AGER, CRP

GO Terms for genes affiliated with Vascular Disease

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Cellular components related to Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.6FGB, ALB, APOA2
2high-density lipoprotein particleGO:0343649.6APOA2, CETP
3external side of plasma membraneGO:0098979.3SELP, VCAM1, ACE, FGB
4extracellular vesicular exosomeGO:0700628.7BHMT2, ALB, CST3, ACE, CETP, APOA2
5platelet alpha granule lumenGO:0310938.7PPBP, VEGFA, SERPINE1, ALB, FGB
6extracellular spaceGO:0056156.2PPBP, SFTPD, VEGFA, SERPINE1, SELE, SELP
7extracellular regionGO:0055765.7FGB, PPBP, SFTPD, VEGFA, APOA2, SERPINE1

Biological processes related to Vascular Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1induction of positive chemotaxisGO:05093010.1AGER, VEGFA
2low-density lipoprotein particle remodelingGO:03437410.1CETP, APOA2
3surfactant homeostasisGO:04312910.0VEGFA, SFTPD
4methionine biosynthetic processGO:00908610.0BHMT2, MTHFR
5high-density lipoprotein particle remodelingGO:03437510.0CETP, APOA2
6positive regulation of leukocyte migrationGO:00268710.0SELP, SELE, VEGFA
7acute inflammatory responseGO:00252610.0VCAM1, APOA2
8negative regulation of macrophage derived foam cell differentiationGO:0107459.9CETP, CRP
9lipoprotein metabolic processGO:0421579.9APOA2, CETP, ALB
10cellular response to vascular endothelial growth factor stimulusGO:0359249.9VCAM1, VEGFA
11leukocyte tethering or rollingGO:0509019.8SELE, SELP, VCAM1
12leukocyte cell-cell adhesionGO:0071599.8VCAM1, SELP, SELE
13reverse cholesterol transportGO:0436919.8CETP, APOA2
14heterophilic cell-cell adhesionGO:0071579.8SELE, SELP, VCAM1
15positive regulation of receptor internalizationGO:0020929.7SELE, VEGFA
16response to hypoxiaGO:0016669.6CRP, MTHFR, VCAM1, VEGFA
17response to lipopolysaccharideGO:0324969.5SELE, SELP, VCAM1
18inflammatory responseGO:0069548.9SELE, SELP, CRP, RARRES2, AGER
19platelet degranulationGO:0025768.6FGB, ALB, SELP, SERPINE1, VEGFA, PPBP
20platelet activationGO:0301688.6PPBP, VEGFA, SERPINE1, SELP, ALB, FGB
21blood coagulationGO:0075968.4PPBP, VEGFA, SERPINE1, SELE, SELP, ALB

Molecular functions related to Vascular Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oligosaccharide bindingGO:0704929.9SELP, SELE
2lipid transporter activityGO:0053199.9CETP, APOA2
3sialic acid bindingGO:0336919.9SELP, SELE
4cholesterol transporter activityGO:0171279.8APOA2, CETP
5cholesterol bindingGO:0154859.6APOA2, CETP, CRP
6phosphatidylcholine bindingGO:0312109.6CETP, APOA2
7protein bindingGO:0055156.6FGB, SFTPD, VEGFA, APOA2, SERPINE1, SELE

Products for genes affiliated with Vascular Disease

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Sources for Vascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet