MCID: VSC007
MIFTS: 72

Vascular Disease malady

Neuronal diseases, Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Vascular Disease

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and renal vascular disease. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Platelet degranulation and Selenium Pathway. The compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and kidney, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A cardiovascular system disease that primarily affects the blood vessels.

Wikipedia:63 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Aliases & Classifications for Vascular Disease

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 9diseasecard, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

vascular disease 8 46 10
vascular diseases 44 33 60
vascular disease, susceptibility to 9
internal elastic lamina 8
arteriopathic disease 60
vascular anomaly 44
arteriopathy 8


External Ids:

Disease Ontology8 DOID:178
NCIt39 C35117
SNOMED-CT56 27550009
MeSH34 D014652
ICD1025 F01.9, K55.9

Related Diseases for Vascular Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 525)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.7SELP, SELE, VCAM1, VWF, MTHFR
2renal vascular disease31.1ALB, ACE
3hypertension31.0ALB, SERPINE1, SELE, VCAM1, ACE, MTHFR
4retinal disease31.0ALB, CETP, SERPINE1, VCAM1, ACE, VWF
5collagen disease30.9CRP
6diabetes mellitus30.8ALB, CETP, SELP, SERPINE1, SELE, VCAM1
7coronary artery disease30.7CETP, SELP, SERPINE1, SELE, VCAM1, ACE
8atherosclerosis30.7ALB, CETP, SELP, SERPINE1, SELE, VCAM1
9obesity30.6CETP, SERPINE1, SELE, AGER, CRP, LPA
10pneumonia30.6CRP
11hyperhomocysteinemia30.5ALB, SELP, SERPINE1, SELE, VCAM1, VWF
12systemic lupus erythematosus30.5SELE, VCAM1, VWF, CRP
13type 2 diabetes mellitus30.5ALB, CETP, SELP, SERPINE1, SELE, VCAM1
14dementia30.4CETP, AGER, LPA, CST3
15vascular dementia30.4VEGFA, MTHFR, LPA, CST3
16alzheimer's disease30.4CETP, HMGCR, PON2, AGER, LPA, PPBP
17stroke, ischemic30.3SELP, SERPINE1, VWF, MTHFR, LPA, PPBP
18neuropathy30.3ALB
19skin disease30.3ALB
20rheumatoid arthritis30.3SELP, SELE, VCAM1, HMGCR, VEGFA, AGER
21ischemic heart disease30.3CETP, SELP, SERPINE1, ACE, HMGCR, CRP
22ischemia30.3SELP, SELE, HMGCR, VEGFA, CST3
23arthritis30.3ALB, SELE, HMGCR, AGER, CRP
24myocardial infarction30.3CETP, SELP, SERPINE1, ACE, HMGCR, VWF
25diabetic nephropathy30.3ALB, SERPINE1, ACE, HMGCR, VWF, PON2
26antiphospholipid syndrome30.3SELP, SELE, VCAM1, VWF, MTHFR
27migraine30.2MTHFR, PPBP
28alagille syndrome30.2LPA, APOA1
29cerebrovascular disease30.2CETP, SELP, ACE, HMGCR, MTHFR, APOB
30vasculitis30.2ALB, SELP, SELE, VCAM1, VWF, CRP
31arteriosclerosis30.2SERPINE1, VCAM1, HMGCR, MTHFR, APOB, APOA1
32carotid stenosis30.2SELP, CRP
33aortic aneurysm30.2CRP
34homocystinuria30.2MTHFR
35hyperglycemia30.1ALB, CETP, SERPINE1, SELE, VCAM1, ACE
36hyperlipidemia type 330.1CETP, HMGCR, LPA, APOB, APOA1
37connective tissue disease30.1ALB, SELE, VCAM1, VWF
38peritonitis30.1ALB, SELP, CRP
39periodontal disease30.1CRP
40thrombophilia30.0SELP, SERPINE1, SELE, VWF, MTHFR, PPBP
41intermittent claudication30.0SELP, VWF
42acquired immunodeficiency syndrome30.0ALB
43systemic scleroderma30.0SELE, VCAM1, ACE, VWF, PPBP
44cadasil29.9CETP, SELP, SERPINE1, ACE, HMGCR, VWF
45essential hypertension29.9ALB, CETP, SELP, SERPINE1, ACE, VWF
46uremia29.9ALB, VCAM1, VWF, AGER, CRP, LPA
47polycystic ovary syndrome29.9SERPINE1, AGER, CRP, APOA1
48familial hypercholesterolemia29.9CETP, HMGCR, APOB
49lung cancer29.9ALB, VEGFA
50crohn's disease29.9ALB, CRP

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Clinical Features for Vascular Disease

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Drugs & Therapeutics for Vascular Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Vascular Disease

Search NIH Clinical Center for Vascular Disease

Search CenterWatch for Vascular Disease

Genetic Tests for Vascular Disease

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Anatomical Context for Vascular Disease

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32MalaCards
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MalaCards organs/tissues related to Vascular Disease:

32
Endothelial, Heart, Kidney, Brain, Bone, Smooth muscle, Lung, Liver, Testes, Skin, Spinal cord, Monocytes, Breast, Retina, Eye, Bone marrow, Prostate, Pancreas, Skeletal muscle, Colon, Cortex, B cells, Myeloid, Thyroid, Ovary, Lymph node, Pons, Nk cells, Whole blood, Adipocyte, Small intestine, T cells

Animal Models for Vascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.4AGER, VEGFA, PON2, VWF, ACE, VCAM1
2MP:000538511.8SELP, CST3, APOA1, APOB, CRP, AGER
3MP:000538711.8SELE, VEGFA, AGER, CRP, APOA1, VWF
4MP:000537011.5APOB, VEGFA, ACE, SELE, SERPINE1, SELP
5MP:001076811.5SELE, SERPINE1, SELP, ALB, VCAM1, ACE
6MP:000539711.4SERPINE1, SELP, APOA1, AGER, VEGFA, VWF
7MP:001077110.6VEGFA

Publications for Vascular Disease

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Sources:
50PubMed
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Articles related to Vascular Disease:

(show top 50)    (show all 2581)
idTitleAuthorsYear
1
Intravascular brachytherapy for peripheral vascular disease. (24399686)
2014
2
Analysis of 27 cases of large vascular lesions in 161 cases of Behcet's disease: clinical manifestations and treatment outcome. (24424838)
2014
3
PINK1 and Its Familial Parkinson's Disease-Associated Mutation Regulate Brain Vascular Endothelial Inflammation. (24385196)
2014
4
Lowering vascular calcification burden in chronic kidney disease: Is it possible? (24255887)
2013
5
Malnutrition and its association with inflammation and vascular disease in children on maintenance dialysis. (23765444)
2013
6
Clinical implications of the angiosome model in peripheral vascular disease. (23972249)
2013
7
Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: the SABPA study. (23380269)
2013
8
A time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population. (23374090)
2013
9
Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease. (22327235)
2012
10
Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension. (22745307)
2012
11
CREG: a possible candidate for both prevention and treatment of proliferative vascular disease. (22834829)
2012
12
Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. (22163231)
2011
13
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. (21419184)
2011
14
Elevated antibody titers to Porphyromonas gingivalis as a possible predictor of ischemic vascular disease - results from the Tokamachi-Nakasato cohort study. (21670558)
2011
15
Regular exercise may ward off cognitive decline in women with vascular disease. (22132440)
2011
16
Carotid plaque and intima-media thickness and the incidence of ischemic events in patients with atherosclerotic vascular disease. (21908682)
2011
17
Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes. (21930272)
2011
18
Pharmacological interventions on asymmetric dimethylarginine, a clinical marker of vascular disease. (21182486)
2011
19
Erectile dysfunction: a vascular disease in the field of urology. (22031618)
2011
20
Vascular disease in systemic sclerosis. (21375075)
2011
21
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
22
The relation of serum vascular endothelial growth factor level with disease duration and activity in patients with rheumatoid arthritis. (20069330)
2010
23
Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. (20739645)
2010
24
Endothelial progenitor cells and vascular disease: are they for real? (21135376)
2010
25
Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease. (20537331)
2010
26
The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects. (19519304)
2009
27
Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. (19423857)
2009
28
Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. (19587802)
2009
29
The difference between mean plasma levels of von Willebrand factor and platelet aggregation in type 2 diabetes mellitus with and without peripheral vascular disease at Sardjito General Hospital, Yogyakarta. (19390122)
2009
30
Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). (17641482)
2007
31
Differing distributions of CXCR3- and CCR4-positive cells among types of interstitial pneumonia associated with collagen vascular diseases. (17124600)
2007
32
Peripheral vascular disease and outcomes following coronary artery bypass graft surgery. (17178964)
2006
33
Mammography as a screening tool for peripheral vascular disease. (16978956)
2006
34
Statin use and sex-specific stroke outcomes in patients with vascular disease. (16645137)
2006
35
Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped. (15654296)
2005
36
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. (19078779)
2005
37
Dysphagia lusoria caused by aberrant right subclavian artery, Kommerell's diverticulum, legamentum ring, right descending aorta, and absent left pulmonary artery: a report of a unique vascular congenital disease undetected until adulthood and a review of the literature. (16088417)
2005
38
Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor. (15033248)
2004
39
Endovascular treatment of peripheral vascular disease: before or after coronary surgery? (16237986)
2004
40
Transforming growth factor (TGF)-beta1 inversely related to vascular cell adhesion molecule-1 in postmenopausal women with coronary artery disease. A possible mechanism for the putative cardioprotective role of TGF-beta1? (11886481)
2002
41
Prevalence of coronary artery disease in patients with symptomatic peripheral vascular disease. (11428475)
2001
42
Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. (11390343)
2001
43
Circulating immune complexes and complement C4 null alleles in patients in patients operated on for premature atherosclerotic peripheral vascular disease. (10634214)
1999
44
Asymptomatic carotid artery stenosis associated with peripheral vascular disease: a prospective study. (10073759)
1999
45
The effects of dipyridamole stress test on plasma levels of soluble adhesion molecules intracellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin and L-selectin in patients with ischemic heart disease and patients with syndrome X. (10376202)
1999
46
Amputation surgery in peripheral vascular disease. (10098097)
1999
47
Homocysteinemia: new information about an old risk factor for vascular disease. (10537928)
1998
48
Antiphospholipid antibodies and retinal vascular disease. (8869905)
1996
49
Semiconductor diode laser photocoagulation in retinal vascular disease. (2255529)
1990
50
Symposium on retinal vascular disease. Conclusion. (1070875)
1976

Genetic Variations for Vascular Disease

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Expression for genes affiliated with Vascular Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Disease

Search GEO for disease gene expression data for Vascular Disease.

Pathways for genes affiliated with Vascular Disease

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 29KEGG
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Compounds for genes affiliated with Vascular Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 256)
idCompoundScoreTop Affiliating Genes
1cholesterol44 28 11 2416.0CST3, SELE, SERPINE1, SELP, CETP, ALB
2lipid4412.7CRP, AGER, PON2, HMGCR, ACE, VCAM1
3creatinine4412.7CST3, APOB, PPBP, LPA, CRP, MTHFR
4homocysteine44 2413.6ALB, CETP, SELP, CST3, APOA1, SERPINE1
5aspirin44 49 28 2415.5LPA, CRP, MTHFR, VWF, HMGCR, ACE
6fibrinogen4412.4APOA1, PPBP, LPA, CRP, MTHFR, VWF
7vegf4412.4LPA, VWF, VEGFA, PPBP, AGER, CRP
8prostacyclin4412.3APOA1, SELP, SERPINE1, PPBP, CRP, AGER
9atorvastatin44 49 28 11 2416.3SERPINE1, CRP, VEGFA, VWF, SELP, CETP
10simvastatin44 49 59 28 11 2417.3CRP, APOB, APOA1, LPA, VCAM1, VEGFA
11lactate4412.1APOB, PPBP, CRP, APOA1, HMGCR, VCAM1
12fenofibrate44 49 1114.1SELP, SERPINE1, SELE, VCAM1, HMGCR, CRP
13pravastatin44 49 28 11 2416.1SELP, APOA1, SERPINE1, SELE, VCAM1, HMGCR
14fluvastatin44 49 28 1115.1SELP, CETP, SERPINE1, SELE, VCAM1, HMGCR
15heparin44 28 11 2415.1CETP, SELP, SELE, VCAM1, PPBP, LPA
16alanine4412.0CETP, SELE, VCAM1, MTHFR, ALB, PPBP
17folate4411.9VWF, CRP, LPA, APOB, CST3, VCAM1
18testosterone44 59 11 2414.9VCAM1, APOA1, CRP, APOB, SERPINE1, ALB
19n acetylcysteine4411.9HMGCR, SELE, VEGFA, VWF, SELP, VCAM1
20vitamin b124411.8CST3, APOA1, APOB, LPA, CRP, MTHFR
21metformin44 49 1113.8APOB, APOA1, MTHFR, CRP, SERPINE1, ACE
22losartan44 49 28 1114.8SELP, ALB, SELE, VCAM1, SERPINE1, ACE
23polysulfone4411.7CST3, ALB, SELP, VCAM1, VWF, CRP
24bezafibrate44 28 1113.7CETP, SERPINE1, HMGCR, LPA, APOA1, APOB
25sele4411.6ACE, SELP, VCAM1, MTHFR, SELE, CETP
26ramipril44 1112.5ACE, CST3, ALB, SERPINE1, HMGCR, CRP
27aspartate4411.5ALB, CST3, CETP, SELE, VCAM1, APOA1
28perindopril44 49 1113.5CRP, VWF, ACE, ALB, SERPINE1, VEGFA
29probucol44 1112.5SELE, CETP, APOB, HMGCR, VCAM1, APOA1
30candesartan44 28 1113.5SELP, AGER, VEGFA, ACE, SERPINE1, ALB
31warfarin44 49 11 2414.5SELP, VWF, LPA, PPBP, HMGCR
32kininogen4411.5APOB, SERPINE1, ACE, CST3, VWF
33rosuvastatin44 49 28 1114.5APOB, ALB, CETP, HMGCR, CRP, APOA1
34clopidogrel49 44 11 2414.5SELP, ACE, HMGCR, CRP, PPBP, VWF
35quinapril44 1112.5SELP, SELE, ACE, SERPINE1, CRP
36thyroxine44 2412.4APOA1, VWF, HMGCR, ALB, CETP, LPA
37vitamin a44 11 2413.4CETP, CST3, APOA1, APOB, LPA
38iohexol4411.4CST3, APOA1, PPBP, ALB, SELP
39gemfibrozil44 28 1113.4LPA, APOB, APOA1, SERPINE1, CETP
40glucose4411.3PPBP, APOA1, CST3, LPA, PON2
41valsartan44 59 28 1114.2SERPINE1, SELP, ALB, CRP, ACE
42pioglitazone44 49 28 1114.2VCAM1, SERPINE1, APOA1, APOB, CRP, VEGFA
43tibolone4411.2SELE, CRP, APOA1, SERPINE1, APOB
44dextran sulfate4411.2SELP, CETP, APOB, APOA1
45uric acid44 2412.1CST3, SERPINE1
46amlodipine44 49 11 2414.1ACE, VCAM1, SERPINE1, HMGCR, ALB
47hydrochlorothiazide44 49 28 11 2415.0CRP, ACE, SERPINE1, ALB, APOA1
48rosiglitazone44 49 28 11 2414.8VCAM1
49dexamethasone44 49 28 1113.8VEGFA, PPBP
50ezetimibe44 1111.8APOA1, CETP, HMGCR, CRP, APOB

GO Terms for genes affiliated with Vascular Disease

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16Gene Ontology
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Cellular components related to Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1PON2, CST3, ALB, CETP, SERPINE1, ACE
2extracellular spaceGO:00561512.1CST3, CETP, SELP, SERPINE1, SELE, VCAM1
3plasma membraneGO:00588611.7APOA1, CRP, AGER, PON2, ACE, VCAM1
4platelet alpha granule lumenGO:03109311.0ALB, SERPINE1, VWF, VEGFA, PPBP
5external side of plasma membraneGO:00989710.6VWF, ACE, VCAM1, SELP

Biological processes related to Vascular Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.9APOB, PPBP, VEGFA, VWF, SELE, ALB
2platelet degranulationGO:00257611.6ALB, APOA1, PPBP, VEGFA, VWF, SERPINE1
3platelet activationGO:03016811.6PPBP, VWF, APOA1, ALB, SELP, SERPINE1
4lipoprotein metabolic processGO:04215711.4ALB, APOA1, APOB, LPA, CETP
5response to nutrientGO:00758411.2APOA1, HMGCR, ALB, VCAM1
6small molecule metabolic processGO:04428111.2CETP, APOA1, APOB, MTHFR, HMGCR, ALB
7positive regulation of leukocyte migrationGO:00268711.1VEGFA, SELE, SELP
8leukocyte tethering or rollingGO:05090111.1SELP, SELE, VCAM1
9cholesterol transportGO:03030111.1CETP, APOA1, APOB
10leukocyte cell-cell adhesionGO:00715911.1VCAM1, SELE, SELP
11heterophilic cell-cell adhesionGO:00715711.1SELE, SELP, VCAM1
12receptor-mediated endocytosisGO:00689811.1CETP, LPA, APOB
13cholesterol homeostasisGO:04263211.0CETP, APOA1, APOB
14lipoprotein biosynthetic processGO:04215811.0APOA1, APOB
15negative regulation of endopeptidase activityGO:01095110.9LPA, CST3, SERPINE1
16cholesterol metabolic processGO:00820310.9APOB, APOA1, CETP
17negative regulation of wound healingGO:06104510.9HMGCR, SERPINE1
18methionine biosynthetic processGO:00908610.9BHMT2, MTHFR
19agingGO:00756810.8HMGCR, VCAM1, CRP
20phospholipid homeostasisGO:05509110.7APOA1, CETP
21low-density lipoprotein particle remodelingGO:03437410.4CETP, APOB

Molecular functions related to Vascular Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.9APOA1, ALB, SELP, SERPINE1, SELE, ACE
2heparin bindingGO:00820111.1SELP, VEGFA, APOB, LPA
3cholesterol transporter activityGO:01712711.0APOA1, APOB, CETP
4cholesterol bindingGO:01548511.0CETP, CRP, APOA1
5oligosaccharide bindingGO:07049210.8SELE, SELP
6phospholipid transporter activityGO:00554810.7APOA1, CETP
7sialic acid bindingGO:03369110.7SELP, SELE
8protease bindingGO:00202010.5CST3, VWF, SERPINE1

Products for genes affiliated with Vascular Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet