MCID: VSC007
MIFTS: 72

Vascular Disease malady

Neuronal diseases, Gastrointestinal diseases, Cardiovascular diseases categories

Summaries for Vascular Disease

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and renal vascular disease. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Platelet degranulation and Selenium Pathway. The compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and kidney, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A cardiovascular system disease that primarily affects the blood vessels.

Wikipedia:63 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Aliases & Classifications for Vascular Disease

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 9diseasecard, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

vascular disease 8 46 10
vascular diseases 44 33 60
vascular disease, susceptibility to 9
internal elastic lamina 8
arteriopathic disease 60
vascular anomaly 44
arteriopathy 8


External Ids:

Disease Ontology8 DOID:178
NCIt39 C35117
SNOMED-CT56 27550009
MeSH34 D014652
ICD1025 F01.9, K55.9

Related Diseases for Vascular Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 525)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.7SELP, SELE, VCAM1, VWF, MTHFR
2renal vascular disease31.1ALB, ACE
3hypertension31.0ALB, SERPINE1, SELE, VCAM1, ACE, MTHFR
4retinal disease31.0ALB, CETP, SERPINE1, VCAM1, ACE, VWF
5collagen disease30.9CRP
6diabetes mellitus30.8ALB, CETP, SELP, SERPINE1, SELE, VCAM1
7coronary artery disease30.7CETP, SELP, SERPINE1, SELE, VCAM1, ACE
8atherosclerosis30.7ALB, CETP, SELP, SERPINE1, SELE, VCAM1
9obesity30.6CETP, SERPINE1, SELE, AGER, CRP, LPA
10pneumonia30.6CRP
11hyperhomocysteinemia30.5ALB, SELP, SERPINE1, SELE, VCAM1, VWF
12systemic lupus erythematosus30.5SELE, VCAM1, VWF, CRP
13type 2 diabetes mellitus30.5ALB, CETP, SELP, SERPINE1, SELE, VCAM1
14dementia30.4CETP, AGER, LPA, CST3
15vascular dementia30.4VEGFA, MTHFR, LPA, CST3
16alzheimer's disease30.4CETP, HMGCR, PON2, AGER, LPA, PPBP
17stroke, ischemic30.3SELP, SERPINE1, VWF, MTHFR, LPA, PPBP
18neuropathy30.3ALB
19skin disease30.3ALB
20rheumatoid arthritis30.3SELP, SELE, VCAM1, HMGCR, VEGFA, AGER
21ischemic heart disease30.3CETP, SELP, SERPINE1, ACE, HMGCR, CRP
22ischemia30.3SELP, SELE, HMGCR, VEGFA, CST3
23arthritis30.3ALB, SELE, HMGCR, AGER, CRP
24myocardial infarction30.3CETP, SELP, SERPINE1, ACE, HMGCR, VWF
25diabetic nephropathy30.3ALB, SERPINE1, ACE, HMGCR, VWF, PON2
26antiphospholipid syndrome30.3SELP, SELE, VCAM1, VWF, MTHFR
27migraine30.2MTHFR, PPBP
28alagille syndrome30.2LPA, APOA1
29cerebrovascular disease30.2CETP, SELP, ACE, HMGCR, MTHFR, APOB
30vasculitis30.2ALB, SELP, SELE, VCAM1, VWF, CRP
31arteriosclerosis30.2SERPINE1, VCAM1, HMGCR, MTHFR, APOB, APOA1
32carotid stenosis30.2SELP, CRP
33aortic aneurysm30.2CRP
34homocystinuria30.2MTHFR
35hyperglycemia30.1ALB, CETP, SERPINE1, SELE, VCAM1, ACE
36hyperlipidemia type 330.1CETP, HMGCR, LPA, APOB, APOA1
37connective tissue disease30.1ALB, SELE, VCAM1, VWF
38peritonitis30.1ALB, SELP, CRP
39periodontal disease30.1CRP
40thrombophilia30.0SELP, SERPINE1, SELE, VWF, MTHFR, PPBP
41intermittent claudication30.0SELP, VWF
42acquired immunodeficiency syndrome30.0ALB
43systemic scleroderma30.0SELE, VCAM1, ACE, VWF, PPBP
44cadasil29.9CETP, SELP, SERPINE1, ACE, HMGCR, VWF
45essential hypertension29.9ALB, CETP, SELP, SERPINE1, ACE, VWF
46uremia29.9ALB, VCAM1, VWF, AGER, CRP, LPA
47polycystic ovary syndrome29.9SERPINE1, AGER, CRP, APOA1
48familial hypercholesterolemia29.9CETP, HMGCR, APOB
49lung cancer29.9ALB, VEGFA
50crohn's disease29.9ALB, CRP

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Clinical Features for Vascular Disease

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Drugs & Therapeutics for Vascular Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Vascular Disease

Search NIH Clinical Center for Vascular Disease

Search CenterWatch for Vascular Disease

Genetic Tests for Vascular Disease

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Anatomical Context for Vascular Disease

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32MalaCards
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MalaCards organs/tissues related to Vascular Disease:

32
Endothelial, Heart, Kidney, Brain, Bone, Smooth muscle, Lung, Liver, Testes, Skin, Spinal cord, Monocytes, Breast, Retina, Eye, Bone marrow, Skeletal muscle, Pancreas, Prostate, Lymph node, Ovary, Cortex, B cells, Thyroid, Colon, Myeloid, Pons, Nk cells, T cells, Small intestine, Whole blood, Adipocyte

Animal Models for Vascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.4AGER, MTHFR, CRP, APOB, APOA1, CST3
2MP:000538511.8SELP, CST3, APOA1, APOB, CRP, AGER
3MP:000538711.8APOA1, CRP, AGER, VEGFA, PON2, VWF
4MP:000537011.5APOA1, APOB, VEGFA, ACE, SELE, SERPINE1
5MP:001076811.5APOB, MTHFR, VEGFA, VWF, HMGCR, ACE
6MP:000539711.4APOA1, AGER, VEGFA, VWF, ACE, VCAM1
7MP:001077110.6VEGFA

Publications for Vascular Disease

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Sources:
50PubMed
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Articles related to Vascular Disease:

(show top 50)    (show all 2581)
idTitleAuthorsYear
1
Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease. (24321840)
2013
2
Vascular endothelial growth factor--marker for proliferation in thyroid diseases? (23329570)
2013
3
Postprandial lipaemia and vascular disease. (23591556)
2013
4
The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD). (23971643)
2013
5
Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. (22595400)
2012
6
Advances in the management of patients with vascular disease. (22292870)
2012
7
Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. (22566581)
2012
8
Silent brain infarction in the presence of systemic vascular disease. (24175060)
2012
9
Risk of vascular disease in patients with multiple sclerosis: a review. (22709796)
2012
10
Management of patients with poly-vascular disease: priorities for revascularization procedures. (23259568)
2012
11
New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk. (21459267)
2011
12
Lower limb vascular disease in diabetic patients: a study with calf compression contrast-enhanced magnetic resonance angiography at 3.0 Tesla. (21470880)
2011
13
Systemic vascular diseases in the antiphospholipid syndrome. What is the best diagnostic choice? (21095242)
2011
14
Matrix metalloproteinase-9 in vascular lesions and endothelial regulation in Kawasaki disease. (20534943)
2010
15
Lipoprotein-associated phospholipase Aa88 activity and mass in relation to vascular disease and nonvascular mortality. (21050287)
2010
16
Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study. (20626720)
2010
17
Nonspecific interstitial pneumonia associated with collagen vascular disease: analysis of CT features to distinguish the various types. (19443969)
2009
18
Neuropsychiatric profiles of patients with Alzheimer's disease and vascular dementia in Taiwan. (19051223)
2009
19
Advanced pulmonary vascular disease: the Eisenmenger syndrome. (19419605)
2009
20
Advanced pulmonary vascular disease: the Eisenmenger syndrome. (19825249)
2009
21
The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease. (17971074)
2008
22
An overview of the pathophysiology of vascular calcification in chronic kidney disease. (17556308)
2007
23
Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease. (17100625)
2006
24
Visual association memory test in differentiating early stage of Alzheimer's disease from vascular dementia. (16871896)
2006
25
Coronary artery disease and peripheral vascular disease in chronic kidney disease: an epidemiological perspective. (16084278)
2005
26
Mechanisms of pulmonary vascular complications of liver disease: hepatopulmonary syndrome. (15758649)
2005
27
Localized Castleman's disease presenting as a vascular right iliac fossa mass. (14719517)
2004
28
Chymase as a novel target for the prevention of vascular diseases. (15380935)
2004
29
Inability of vascular smooth muscle cells to proceed beyond S phase of cell cycle, and increased apoptosis in symptomatic carotid artery disease. (12844105)
2003
30
Evaluation of patients with peripheral vascular disease. (12359343)
2002
31
Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases. (11770867)
2001
32
Vascular disease in mixed connective tissue disease (MCTD). (11813839)
2001
33
Parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy in patients with peripheral vascular disease and in healthy volunteers. (11339328)
2001
34
Prevalence of subclavian artery stenosis in patients with peripheral vascular disease. (11269782)
2001
35
Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease. (11463719)
2001
36
Role of thrombotic vascular risk factors in inflammatory bowel disease. (11279334)
2000
37
Acanthosis nigricans in obese patients: Presentations and implications for prevention of atherosclerotic vascular disease. (11328611)
2000
38
Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease. (10335769)
1999
39
The epidemiology and cost of inpatient care for peripheral vascular disease, infection, neuropathy, and ulceration in diabetes. (9538969)
1998
40
Factors determining cardiac hypertrophy in hypertensive patients with or without peripheral vascular disease. (9730844)
1998
41
Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64. (9414294)
1998
42
New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. (9180243)
1997
43
Progression of peripheral vascular disease after combined kidney-pancreas transplantation in diabetic patients with end-stage renal failure. (9123467)
1997
44
Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes. (8611873)
1996
45
Role of insulin and proinsulin in diabetic vascular disease. (7476316)
1995
46
Pulmonary involvement of collagen vascular diseases: studies on prognostic factors from basic and clinical viewpoints]. (8752521)
1995
47
Pulmonary vascular damage and the development of cor pulmonale following hyaline membrane disease. (2148977)
1990
48
Initial clinical experience using a diode laser in the treatment of retinal vascular disease. (2630328)
1989
49
RENAL VASCULAR DISEASE. (14328536)
1964
50
Undetected diabetes in patients with early vascular and gallbladder disease. (14492693)
1962

Genetic Variations for Vascular Disease

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Expression for genes affiliated with Vascular Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vascular Disease

Search GEO for disease gene expression data for Vascular Disease.

Pathways for genes affiliated with Vascular Disease

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 29KEGG
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Compounds for genes affiliated with Vascular Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 256)
idCompoundScoreTop Affiliating Genes
1cholesterol44 28 11 2416.0CST3, SELE, SERPINE1, SELP, CETP, ALB
2lipid4412.7CRP, AGER, PON2, HMGCR, ACE, VCAM1
3creatinine4412.7CST3, APOB, PPBP, LPA, CRP, MTHFR
4homocysteine44 2413.6ALB, CETP, SELP, CST3, APOA1, SERPINE1
5aspirin44 49 28 2415.5LPA, CRP, MTHFR, VWF, HMGCR, ACE
6fibrinogen4412.4APOA1, PPBP, LPA, CRP, MTHFR, VWF
7vegf4412.4LPA, VWF, VEGFA, PPBP, AGER, CRP
8prostacyclin4412.3APOA1, SELP, SERPINE1, PPBP, CRP, AGER
9atorvastatin44 49 28 11 2416.3SERPINE1, CRP, VEGFA, VWF, SELP, CETP
10simvastatin44 49 59 28 11 2417.3CRP, APOB, APOA1, LPA, VCAM1, VEGFA
11lactate4412.1APOB, PPBP, CRP, APOA1, HMGCR, VCAM1
12fenofibrate44 49 1114.1SELP, SERPINE1, SELE, VCAM1, HMGCR, CRP
13pravastatin44 49 28 11 2416.1SELP, APOA1, SERPINE1, SELE, VCAM1, HMGCR
14fluvastatin44 49 28 1115.1SELP, CETP, SERPINE1, SELE, VCAM1, HMGCR
15heparin44 28 11 2415.1CETP, SELP, SELE, VCAM1, PPBP, LPA
16alanine4412.0CETP, SELE, VCAM1, MTHFR, ALB, PPBP
17folate4411.9VWF, CRP, LPA, APOB, CST3, VCAM1
18testosterone44 59 11 2414.9VCAM1, APOA1, CRP, APOB, SERPINE1, ALB
19n acetylcysteine4411.9HMGCR, SELE, VEGFA, VWF, SELP, VCAM1
20vitamin b124411.8CST3, APOA1, APOB, LPA, CRP, MTHFR
21metformin44 49 1113.8APOB, APOA1, MTHFR, CRP, SERPINE1, ACE
22losartan44 49 28 1114.8SELP, ALB, SELE, VCAM1, SERPINE1, ACE
23polysulfone4411.7CST3, ALB, SELP, VCAM1, VWF, CRP
24bezafibrate44 28 1113.7CETP, SERPINE1, HMGCR, LPA, APOA1, APOB
25sele4411.6ACE, SELP, VCAM1, MTHFR, SELE, CETP
26ramipril44 1112.5ACE, CST3, ALB, SERPINE1, HMGCR, CRP
27aspartate4411.5ALB, CST3, CETP, SELE, VCAM1, APOA1
28perindopril44 49 1113.5CRP, VWF, ACE, ALB, SERPINE1, VEGFA
29probucol44 1112.5SELE, CETP, APOB, HMGCR, VCAM1, APOA1
30candesartan44 28 1113.5SELP, AGER, VEGFA, ACE, SERPINE1, ALB
31warfarin44 49 11 2414.5SELP, VWF, LPA, PPBP, HMGCR
32kininogen4411.5APOB, SERPINE1, ACE, CST3, VWF
33rosuvastatin44 49 28 1114.5APOB, ALB, CETP, HMGCR, CRP, APOA1
34clopidogrel49 44 11 2414.5SELP, ACE, HMGCR, CRP, PPBP, VWF
35quinapril44 1112.5SELP, SELE, ACE, SERPINE1, CRP
36thyroxine44 2412.4APOA1, VWF, HMGCR, ALB, CETP, LPA
37vitamin a44 11 2413.4CETP, CST3, APOA1, APOB, LPA
38iohexol4411.4CST3, APOA1, PPBP, ALB, SELP
39gemfibrozil44 28 1113.4LPA, APOB, APOA1, SERPINE1, CETP
40glucose4411.3PPBP, APOA1, CST3, LPA, PON2
41valsartan44 59 28 1114.2SERPINE1, SELP, ALB, CRP, ACE
42pioglitazone44 49 28 1114.2VCAM1, SERPINE1, APOA1, APOB, CRP, VEGFA
43tibolone4411.2SELE, CRP, APOA1, SERPINE1, APOB
44dextran sulfate4411.2SELP, CETP, APOB, APOA1
45uric acid44 2412.1CST3, SERPINE1
46amlodipine44 49 11 2414.1ACE, VCAM1, SERPINE1, HMGCR, ALB
47hydrochlorothiazide44 49 28 11 2415.0CRP, ACE, SERPINE1, ALB, APOA1
48rosiglitazone44 49 28 11 2414.8VCAM1
49dexamethasone44 49 28 1113.8VEGFA, PPBP
50ezetimibe44 1111.8APOA1, CETP, HMGCR, CRP, APOB

GO Terms for genes affiliated with Vascular Disease

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16Gene Ontology
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Cellular components related to Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1CRP, LPA, PPBP, APOB, APOA1, CST3
2extracellular spaceGO:00561512.1ALB, CST3, APOA1, APOB, PPBP, CRP
3plasma membraneGO:00588611.7APOB, CRP, AGER, PON2, ACE, VCAM1
4platelet alpha granule lumenGO:03109311.0PPBP, VEGFA, VWF, SERPINE1, ALB
5external side of plasma membraneGO:00989710.6VWF, ACE, VCAM1, SELP

Biological processes related to Vascular Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.9APOA1, APOB, PPBP, VEGFA, VWF, SELE
2platelet degranulationGO:00257611.6ALB, APOA1, PPBP, VEGFA, VWF, SERPINE1
3platelet activationGO:03016811.6APOA1, PPBP, VEGFA, VWF, SERPINE1, SELP
4lipoprotein metabolic processGO:04215711.4APOA1, APOB, LPA, CETP, ALB
5response to nutrientGO:00758411.2ALB, VCAM1, HMGCR, APOA1
6small molecule metabolic processGO:04428111.2APOA1, APOB, LPA, MTHFR, HMGCR, CETP
7positive regulation of leukocyte migrationGO:00268711.1VEGFA, SELE, SELP
8leukocyte tethering or rollingGO:05090111.1SELP, SELE, VCAM1
9cholesterol transportGO:03030111.1APOA1, APOB, CETP
10leukocyte cell-cell adhesionGO:00715911.1SELP, SELE, VCAM1
11heterophilic cell-cell adhesionGO:00715711.1VCAM1, SELE, SELP
12receptor-mediated endocytosisGO:00689811.1APOB, LPA, CETP
13cholesterol homeostasisGO:04263211.0CETP, APOB, APOA1
14lipoprotein biosynthetic processGO:04215811.0APOB, APOA1
15negative regulation of endopeptidase activityGO:01095110.9CST3, LPA, SERPINE1
16cholesterol metabolic processGO:00820310.9CETP, APOB, APOA1
17methionine biosynthetic processGO:00908610.9BHMT2, MTHFR
18negative regulation of wound healingGO:06104510.9SERPINE1, HMGCR
19agingGO:00756810.8VCAM1, HMGCR, CRP
20phospholipid homeostasisGO:05509110.7CETP, APOA1
21low-density lipoprotein particle remodelingGO:03437410.4CETP, APOB

Molecular functions related to Vascular Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.9CST3, APOA1, APOB, CRP, AGER, VEGFA
2heparin bindingGO:00820111.1SELP, VEGFA, LPA, APOB
3cholesterol transporter activityGO:01712711.0CETP, APOB, APOA1
4cholesterol bindingGO:01548511.0APOA1, CRP, CETP
5oligosaccharide bindingGO:07049210.8SELE, SELP
6phospholipid transporter activityGO:00554810.7CETP, APOA1
7sialic acid bindingGO:03369110.7SELP, SELE
8protease bindingGO:00202010.5SERPINE1, VWF, CST3

Products for genes affiliated with Vascular Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet