MCID: VSC007
MIFTS: 69

Vascular Disease malady

Neuronal, Gastrointestinal, Cardiovascular categories

Summaries for Vascular Disease

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and atherosclerosis. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Platelet degranulation and Selenium Pathway. The compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A cardiovascular system disease that primarily affects the blood vessels.

Wikipedia:64 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Aliases & Classifications for Vascular Disease

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Gastrointestinal, Cardiovascular


Aliases & Descriptions:

vascular disease 8 47 10
vascular diseases 45 34 61
vascular disease, susceptibility to 9
internal elastic lamina 8
arteriopathic disease 61
vascular anomaly 45
arteriopathy 8


External Ids:

Disease Ontology8 DOID:178
NCIt40 C35117
SNOMED-CT57 27550009
MeSH35 D014652
ICD1025 F01.9, K55.9

Related Diseases for Vascular Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 517)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.8SELP, SELE, VCAM1, VWF, MTHFR
2atherosclerosis30.8ALB, CETP, SELP, SERPINE1, SELE, VCAM1
3coronary artery disease,30.8CETP, SELP, SERPINE1, SELE, VCAM1, ACE
4hyperhomocysteinemia30.6ALB, SELP, SERPINE1, SELE, VCAM1, VWF
5insulin resistance30.5ALB, CETP, SERPINE1, SELE, VCAM1, ACE
6systemic lupus erythematosus30.5SELE, VCAM1, VWF, CRP
7vascular dementia30.5VEGFA, MTHFR, LPA, CST3
8coronary heart disease30.5CETP, SELP, SERPINE1, SELE, VCAM1, ACE
9stroke, ischemic30.4ALB, SERPINE1, SELE, VCAM1, ACE, HMGCR
10arthritis30.4ALB, SELE, HMGCR, AGER, CRP
11antiphospholipid syndrome30.3SELP, SELE, VCAM1, VWF, MTHFR
12homocysteinemia30.3MTHFR
13diabetic nephropathy30.3ALB, SERPINE1, ACE, HMGCR, VWF, PON2
14vasculitis30.2ALB, SELP, SELE, VCAM1, VWF, CRP
15arteriosclerosis30.2SERPINE1, VCAM1, HMGCR, MTHFR, APOB, APOA1
16carotid stenosis30.2SELP, CRP
17aortic aneurysm30.2CRP
18homocystinuria30.2MTHFR
19alagille syndrome30.2LPA, APOA1
20hyperlipidemia type 330.2CETP, HMGCR, LPA, APOB, APOA1
21alzheimer's disease30.1CETP, HMGCR, PON2, AGER, LPA, PPBP
22thrombophilia30.1SELP, SERPINE1, SELE, VWF, MTHFR, PPBP
23rheumatic disease30.1CRP, PPBP, APOB
24pulmonary disease, chronic obstructive30.1CRP
25acquired immunodeficiency syndrome30.1ALB
26systemic scleroderma30.0SELE, VCAM1, ACE, VWF, PPBP
27hypercholesterolemia30.0CETP, SELP, SERPINE1, SELE, VCAM1, ACE
28cadasil30.0CETP, SELP, SERPINE1, ACE, HMGCR, VWF
29hypertriglyceridemia29.9CETP, SERPINE1, SELE, VCAM1, HMGCR, LPA
30uremia29.9ALB, VCAM1, VWF, AGER, CRP, LPA
31thromboembolism29.9SELP, SERPINE1, VWF, MTHFR, APOA1
32polycystic ovary syndrome29.9SERPINE1, AGER, CRP, APOA1
33familial hypercholesterolemia29.9CETP, HMGCR, APOB
34intermittent claudication29.9SELP, VWF
35ankylosing spondylitis29.9CRP
36eisenmenger syndrome29.9VWF
37diabetic angiopathy29.9SELE, AGER
38adenocarcinoma29.8HMGCR, VEGFA
39acute myocardial infarction29.7SELP, SERPINE1, SELE, ACE, HMGCR, VWF
40venous thrombosis29.7CETP, SELP, SERPINE1, HMGCR, VWF, MTHFR
41type 1 diabetes29.7ALB, CETP, ACE, LPA, APOB, APOA1
42fatty liver disease29.7CETP, SERPINE1, HMGCR, APOB, APOA1
43asthma29.7CETP, SELE, VCAM1, PPBP
44thrombocytosis29.7SELP, VWF, CRP, PPBP
45colorectal cancer29.7SELP, VEGFA, MTHFR, CST3
46thrombocytopenia29.7ALB, SELP, VWF, PPBP
47nephritis29.7ALB, VCAM1, ACE
48kawasaki disease29.7SELE, CRP
49lupus nephritis29.7ALB, VCAM1
50hepatitis c29.7ALB, HMGCR

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Clinical Features for Vascular Disease

Drugs & Therapeutics for Vascular Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Vascular Disease

Search NIH Clinical Center for Vascular Disease

Search CenterWatch for Vascular Disease

Genetic Tests for Vascular Disease

Anatomical Context for Vascular Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vascular Disease:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Cortex, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Pons, Atrioventricular node, Fetal liver, Fetal lung, Bronchial epithelium, Fetal thyroid, Pancreatic islet

Animal Models for Vascular Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Vascular Disease

Sources:
51PubMed
See all sources

Articles related to Vascular Disease:

(show top 50)    (show all 2592)
idTitleAuthorsYear
1
Effects of Combination of Perindopril, Indapamide, and Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus: Results From the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial. (24324048)
2014
2
Bioreactors as engineering support to treat cardiac muscle and vascular disease. (23965594)
2013
3
Insulin resistance may contribute to vascular dysfunction in patients with chronic obstructive pulmonary disease. (24343042)
2013
4
Assessing vascular health after Kawasaki disease: a cautionary tale. (23850904)
2013
5
Vascular health in Kawasaki disease. (23835006)
2013
6
Vascular collateralization along ventriculoperitoneal shunt catheters in moyamoya disease. (23581637)
2013
7
Contribution of blood platelets to vascular pathology in Alzheimer's disease. (24235853)
2013
8
Obesity and vascular disease: From bench to bedside. (24029862)
2013
9
Neuropsychiatric symptoms and functional status in Alzheimer's disease and vascular dementia patients. (22715983)
2012
10
2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN/SVS Key data elements and definitions for peripheral atherosclerotic vascular disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to develop Clinical Data Standards for peripheral atherosclerotic vascular disease). (22153885)
2012
11
Homocysteine in occlusive vascular disease: a risk marker or risk factor. (23350275)
2012
12
Air pollution, vascular disease and thrombosis: linking clinical data and pathogenic mechanisms. (23006215)
2012
13
The nuclear factor--kappa B pathway in atherosclerosis: a potential therapeutic target for atherothrombotic vascular disease. (21636112)
2011
14
Serum placental growth factor, vascular endothelial growth factor, soluble vascular endothelial growth factor receptor-1 and -2 levels in periodontal disease, and adverse pregnancy outcomes. (21513467)
2011
15
The role of adiponectin in metabolic and vascular disease: a review. (21176748)
2011
16
Lack of association of KIF6 genotype with vascular disease and statin response. (21846872)
2011
17
The world of pulmonary vascular disease. (22140619)
2011
18
Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. (21674003)
2011
19
Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. (20975015)
2011
20
AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and other Atherosclerotic Vascular Disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation. (22052934)
2011
21
The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. (21361911)
2011
22
Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases. (20085636)
2010
23
The influence of basic ventilation strategies on cerebral oxygenation in anesthetized patients without vascular disease. (21061050)
2010
24
Vascular disease in systemic sclerosis. (21048994)
2010
25
Clinical inquiries. What is the best test for peripheral vascular disease? (18544324)
2008
26
Free and cued selective reminding distinguishes Alzheimer's disease from vascular dementia. (18454754)
2008
27
Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns. (17848614)
2007
28
Sex hormones as novel risk biomarkers for atherosclerosis in peripheral vascular disease. (17825718)
2007
29
C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). (17283264)
2007
30
LOW specificity limits the use of the cerebrospinal fluid AB1-42/P-TAU181P ratio to discriminate alzheimer's disease from vascular dementia. (17702886)
2007
31
Vascular C-reactive protein in the pathogenesis of coronary artery disease: role of vascular inflammation and oxidative stress. (17378768)
2006
32
Association of vascular endothelial growth factor gene polymorphisms with behcet disease in a Korean population. (16386649)
2005
33
Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in oral squamous cell carcinoma: its correlation with angiogenesis and disease progression. (15689226)
2005
34
Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease. (15663785)
2005
35
Is there a fetal origin of peripheral vascular disease? (15958349)
2005
36
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. (12777673)
2003
37
Cartilaginous metaplasia in calcified diabetic peripheral vascular disease: morphologic evidence of enchondral ossification. (12733123)
2003
38
Ethnic differences in peripheral vascular disease. (12425370)
2002
39
Cholesteryl ester transfer protein as a protective factor against vascular disease in hemodialysis patients. (11431184)
2001
40
ACE inhibitors in vascular disease: some PROGRESS, more HOPE. (11773984)
2001
41
Arterial pulse wave velocity and risk factors for peripheral vascular disease. (10879436)
2000
42
Peripheral vascular disease. (11080131)
2000
43
The effects of peripheral vascular disease with osteomyelitis in the diabetic foot. (10326843)
1999
44
Salvage of failed amputation about the hip in peripheral vascular disease by open wound care and nutritional support. (9732079)
1998
45
In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. (8574967)
1996
46
Vascularity of proliferative breast disease and carcinoma in situ correlates with histological features. (9816143)
1996
47
Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. (8281664)
1994
48
Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins. (1783414)
1991
49
Hyperhomocysteinemia: an independent risk factor for vascular disease. (2011158)
1991
50
A new approach to some problems of retinal vascular disease. (18114393)
1949

Genetic Variations for Vascular Disease

Expression for genes affiliated with Vascular Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vascular Disease

Search GEO for disease gene expression data for Vascular Disease.

Pathways for genes affiliated with Vascular Disease

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 30KEGG
See all sources

Compounds for genes affiliated with Vascular Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 256)
idCompoundScoreTop Affiliating Genes
1cholesterol45 29 11 2416.0CST3, SELE, SERPINE1, SELP, CETP, ALB
2lipid4512.7CRP, AGER, PON2, HMGCR, ACE, VCAM1
3creatinine4512.7CST3, APOB, PPBP, LPA, CRP, MTHFR
4homocysteine45 2413.6ALB, CETP, SELP, CST3, APOA1, SERPINE1
5aspirin45 50 29 2415.5LPA, CRP, MTHFR, VWF, HMGCR, ACE
6fibrinogen4512.4APOA1, PPBP, LPA, CRP, MTHFR, VWF
7vegf4512.4LPA, VWF, VEGFA, PPBP, AGER, CRP
8prostacyclin4512.3APOA1, SELP, SERPINE1, PPBP, CRP, AGER
9atorvastatin45 50 29 11 2416.3SERPINE1, CRP, VEGFA, VWF, SELP, CETP
10simvastatin45 50 60 29 11 2417.3CRP, APOB, APOA1, LPA, VCAM1, VEGFA
11lactate4512.1APOB, PPBP, CRP, APOA1, HMGCR, VCAM1
12fenofibrate45 50 1114.1SELP, SERPINE1, SELE, VCAM1, HMGCR, CRP
13pravastatin45 50 29 11 2416.1SELP, APOA1, SERPINE1, SELE, VCAM1, HMGCR
14fluvastatin45 50 29 1115.1SELP, CETP, SERPINE1, SELE, VCAM1, HMGCR
15heparin45 29 11 2415.1CETP, SELP, SELE, VCAM1, PPBP, LPA
16alanine4512.0CETP, SELE, VCAM1, MTHFR, ALB, PPBP
17folate4511.9VWF, CRP, LPA, APOB, CST3, VCAM1
18testosterone45 60 11 2414.9VCAM1, APOA1, CRP, APOB, SERPINE1, ALB
19n acetylcysteine4511.9HMGCR, SELE, VEGFA, VWF, SELP, VCAM1
20vitamin b124511.8CST3, APOA1, APOB, LPA, CRP, MTHFR
21metformin45 50 1113.8APOB, APOA1, MTHFR, CRP, SERPINE1, ACE
22losartan45 50 29 1114.8SELP, ALB, SELE, VCAM1, SERPINE1, ACE
23polysulfone4511.7CST3, ALB, SELP, VCAM1, VWF, CRP
24bezafibrate45 29 1113.7CETP, SERPINE1, HMGCR, LPA, APOA1, APOB
25sele4511.6ACE, SELP, VCAM1, MTHFR, SELE, CETP
26ramipril45 1112.5ACE, CST3, ALB, SERPINE1, HMGCR, CRP
27aspartate4511.5ALB, CST3, CETP, SELE, VCAM1, APOA1
28perindopril45 50 1113.5CRP, VWF, ACE, ALB, SERPINE1, VEGFA
29probucol45 1112.5SELE, CETP, APOB, HMGCR, VCAM1, APOA1
30candesartan45 29 1113.5SELP, AGER, VEGFA, ACE, SERPINE1, ALB
31warfarin45 50 11 2414.5SELP, VWF, LPA, PPBP, HMGCR
32kininogen4511.5APOB, SERPINE1, ACE, CST3, VWF
33rosuvastatin45 50 29 1114.5APOB, ALB, CETP, HMGCR, CRP, APOA1
34clopidogrel50 45 11 2414.5SELP, ACE, HMGCR, CRP, PPBP, VWF
35quinapril45 1112.5SELP, SELE, ACE, SERPINE1, CRP
36thyroxine45 2412.4APOA1, VWF, HMGCR, ALB, CETP, LPA
37vitamin a45 11 2413.4CETP, CST3, APOA1, APOB, LPA
38iohexol4511.4CST3, APOA1, PPBP, ALB, SELP
39gemfibrozil45 29 1113.4LPA, APOB, APOA1, SERPINE1, CETP
40glucose4511.3PPBP, APOA1, CST3, LPA, PON2
41valsartan45 60 29 1114.2SERPINE1, SELP, ALB, CRP, ACE
42pioglitazone45 50 29 1114.2VCAM1, SERPINE1, APOA1, APOB, CRP, VEGFA
43tibolone4511.2SELE, CRP, APOA1, SERPINE1, APOB
44dextran sulfate4511.2SELP, CETP, APOB, APOA1
45uric acid45 2412.1CST3, SERPINE1
46amlodipine45 50 11 2414.1ACE, VCAM1, SERPINE1, HMGCR, ALB
47hydrochlorothiazide45 50 29 11 2415.0CRP, ACE, SERPINE1, ALB, APOA1
48rosiglitazone45 50 29 11 2414.8VCAM1
49dexamethasone45 50 29 1113.8VEGFA, PPBP
50ezetimibe45 1111.8APOA1, CETP, HMGCR, CRP, APOB

GO Terms for genes affiliated with Vascular Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1PON2, CST3, ALB, CETP, SERPINE1, ACE
2extracellular spaceGO:00561512.1CST3, CETP, SELP, SERPINE1, SELE, VCAM1
3plasma membraneGO:00588611.7APOA1, CRP, AGER, PON2, ACE, VCAM1
4platelet alpha granule lumenGO:03109311.0ALB, SERPINE1, VWF, VEGFA, PPBP
5external side of plasma membraneGO:00989710.6VWF, ACE, VCAM1, SELP

Biological processes related to Vascular Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.9APOB, PPBP, VEGFA, VWF, SELE, ALB
2platelet degranulationGO:00257611.6ALB, APOA1, PPBP, VEGFA, VWF, SERPINE1
3platelet activationGO:03016811.6PPBP, VWF, APOA1, ALB, SELP, SERPINE1
4lipoprotein metabolic processGO:04215711.4ALB, APOA1, APOB, LPA, CETP
5response to nutrientGO:00758411.2APOA1, HMGCR, ALB, VCAM1
6small molecule metabolic processGO:04428111.2CETP, APOA1, APOB, MTHFR, HMGCR, ALB
7positive regulation of leukocyte migrationGO:00268711.1VEGFA, SELE, SELP
8leukocyte tethering or rollingGO:05090111.1SELP, SELE, VCAM1
9cholesterol transportGO:03030111.1CETP, APOA1, APOB
10leukocyte cell-cell adhesionGO:00715911.1VCAM1, SELE, SELP
11heterophilic cell-cell adhesionGO:00715711.1SELE, SELP, VCAM1
12receptor-mediated endocytosisGO:00689811.1CETP, LPA, APOB
13cholesterol homeostasisGO:04263211.0CETP, APOA1, APOB
14lipoprotein biosynthetic processGO:04215811.0APOA1, APOB
15negative regulation of endopeptidase activityGO:01095110.9LPA, CST3, SERPINE1
16cholesterol metabolic processGO:00820310.9APOB, APOA1, CETP
17negative regulation of wound healingGO:06104510.9HMGCR, SERPINE1
18methionine biosynthetic processGO:00908610.9BHMT2, MTHFR
19agingGO:00756810.8HMGCR, VCAM1, CRP
20phospholipid homeostasisGO:05509110.7APOA1, CETP
21low-density lipoprotein particle remodelingGO:03437410.4CETP, APOB

Molecular functions related to Vascular Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.9APOA1, ALB, SELP, SERPINE1, SELE, ACE
2heparin bindingGO:00820111.1SELP, VEGFA, APOB, LPA
3cholesterol transporter activityGO:01712711.0APOA1, APOB, CETP
4cholesterol bindingGO:01548511.0CETP, CRP, APOA1
5oligosaccharide bindingGO:07049210.8SELE, SELP
6phospholipid transporter activityGO:00554810.7APOA1, CETP
7sialic acid bindingGO:03369110.7SELP, SELE
8protease bindingGO:00202010.5CST3, VWF, SERPINE1

Products for genes affiliated with Vascular Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vascular Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet