MCID: VSC007
MIFTS: 59

Vascular Disease malady

Mental diseases, Gastrointestinal diseases, Cardiovascular diseases categories

Aliases & Classifications for Vascular Disease

About this section

Summaries for Vascular Disease

About this section


MedlinePlus:32 The vascular system is the body's network of blood vessels. it includes the arteries, veins and capillaries that carry blood to and from the heart. problems of the vascular system are common and can be serious. arteries can become thick and stiff, a problem called atherosclerosis. blood clots can clog vessels and block blood flow to the heart or brain. weakened blood vessels can burst, causing bleeding inside the body. you are more likely to have vascular disease as you get older. other factors that make vascular disease more likely include family history of vascular or heart diseases pregnancy illness or injury long periods of sitting or standing still any condition that affects the heart and blood vessels, such as diabetes or high cholesterol smoking obesity losing weight, eating healthy foods, being active and not smoking can help vascular disease. other treatments include medicines and surgery.

MalaCards based summary: Vascular Disease, also known as vascular diseases, is related to peripheral vascular disease and systemic lupus erythematosus. An important gene associated with Vascular Disease is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are A-beta Plaque Formation and APP Metabolism and Cell adhesion ECM remodeling. The compounds gliclazide and fosinopril have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.

Wikipedia:63 Vascular disease is a form of cardiovascular disease primarily affecting the blood vessels. more...

Related Diseases for Vascular Disease

About this section

Diseases related to Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 419)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease31.9SELE, SELP, MTHFR, VCAM1
2systemic lupus erythematosus31.1CRP
3homocysteinemia31.1MTHFR
4eclampsia30.8MTHFR
5renal artery disease30.7ALB, ACE
6ischemia30.6VEGFA, SELP, SELE, CST3
7atrial fibrillation30.5PPBP, SELP, ACE
8arteriosclerosis30.5VCAM1, SERPINE1, MTHFR
9systemic scleroderma30.5ACE
10dementia30.5AGER, CST3, CETP
11arthritis30.4ALB, CRP, SELE, AGER
12kidney disease30.4CST3, VEGFA, SERPINE1, SELP, VCAM1
13central retinal vein occlusion30.4VEGFA, MTHFR
14retinal vein occlusion30.4MTHFR, VEGFA
15hypertriglyceridemia30.4APOA2, SERPINE1
16connective tissue disease30.4ALB, VCAM1, SELE
17carotid stenosis30.4SELP, CRP
18peritonitis30.3SELP, ALB, CRP
19protein c deficiency30.3MTHFR, SERPINE1
20antiphospholipid syndrome30.3SELE, MTHFR, VCAM1, SELP
21vascular dementia30.3MTHFR, CST3, VEGFA
22collagen disease30.3CRP
23coronary artery disease30.3SELP, CRP, ACE, SERPINE1, CETP
24diabetic angiopathy30.2AGER, SELE
25polycystic ovary syndrome30.1AGER, SERPINE1, CRP
26arteriosclerosis obliterans30.1SELP, VCAM1
27nephritis30.0ACE, VCAM1, ALB
28uremia29.9AGER, CRP, ALB, VCAM1
29essential thrombocythemia29.9SELP, PPBP
30pancreatitis29.8SELP, CRP, ALB
31thrombophilia29.8SERPINE1, SELP, MTHFR, SELE, PPBP
32kawasaki disease29.8SELE, CRP
33cerebrovascular disease29.8MTHFR, CST3, SELP, CETP, ACE
34hyperhomocysteinemia29.8CRP, ALB, CST3, MTHFR, VCAM1, SELP
35congenital heart disease29.8PPBP, CST3, ACE, CETP
36thrombocytopenia29.7ALB, PPBP, SELP
37thrombocytosis29.6PPBP, CRP, SELP
38colorectal cancer29.6SELE, VCAM1, SELP, VEGFA, CST3
39vasculitis29.6PPBP, SELE, CRP, SELP, VCAM1, ALB
40inflammatory bowel disease29.5CRP, VCAM1, SELE, SELP
41obesity29.5SELE, CETP, RARRES2, APOA2, AGER, CRP
42hyperglycemia29.4ALB, CETP, CRP, SERPINE1, ACE, AGER
43proteinuria29.3VEGFA, APOA2, CETP, ACE, CST3, CRP
44breast cancer29.3KLK15, MTHFR, SERPINE1, VEGFA, PPBP, CST3
45melanoma29.2CST3, VEGFA, VCAM1, PPBP, AGER
46asthma29.0CETP, VCAM1, SELE, SFTPD, PPBP
47acute myocardial infarction29.0SERPINE1, SELE, SELP, ACE, CST3, CRP
48rheumatoid arthritis28.7SFTPD, SELE, VCAM1, MTHFR, CST3, CRP
49myocardial infarction28.7SERPINE1, APOA2, PPBP, SELP, PON2, FGB
50atherosclerosis28.7PPBP, APOA2, SERPINE1, SELE, SELP, PON2

Graphical network of the top 20 diseases related to Vascular Disease:



Diseases related to vascular disease

Symptoms for Vascular Disease

About this section

Drugs & Therapeutics for Vascular Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Vascular Disease

Search NIH Clinical Center for Vascular Disease

Genetic Tests for Vascular Disease

About this section

Anatomical Context for Vascular Disease

About this section

MalaCards organs/tissues related to Vascular Disease:

31
Heart, Endothelial, Brain, Kidney, Spinal cord, Bone, Smooth muscle, Skin, Lung, Monocytes, Retina, Pancreas, Testes, Skeletal muscle, Liver, Bone marrow, Eye, Ovary, Pons, Neutrophil, Whole blood, Lymph node, Cortex, Colon, Adipocyte, Breast, Prostate, Myeloid, Nk cells, B cells

Animal Models for Vascular Disease or affiliated genes

About this section

Publications for Vascular Disease

About this section

Articles related to Vascular Disease:

(show top 50)    (show all 1616)
idTitleAuthorsYear
1
Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study. (24430876)
2014
2
Extracellular vesicle-derived CD14 is independently associated with the extent of cardiovascular disease burden in patients with manifest vascular disease. (24398371)
2014
3
Diabetes mellitus and peripheral vascular disease: diagnosis and management. (24296015)
2014
4
Same-day discharge after angioplasty for peripheral vascular disease: is it a safe and feasible option? (25131758)
2014
5
Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (25351520)
2014
6
Bioreactors as engineering support to treat cardiac muscle and vascular disease. (23965594)
2013
7
Impact of Smoking on Long-Term Outcomes in Patients with Atherosclerotic Vascular Disease Treated with Aspirin or Clopidogrel: Insights from the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) Trial. (24239662)
2013
8
Impact of estimated glomerular filtration rate on vascular disease extent and adverse cardiovascular events in patients without chronic kidney disease. (23317678)
2013
9
Relation between aortic valve sclerosis and ankle-brachial index in participants clinically free of atherosclerotic vascular disease. (23267238)
2013
10
Peripheral vascular disease as remote ischemic preconditioning, for acute stroke. (23958050)
2013
11
Mitochondria in vascular disease. (22392270)
2012
12
Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease. (22272893)
2012
13
The risk of general and abdominal adiposity in the occurrence of new vascular events and mortality in patients with various manifestations of vascular disease. (21712810)
2012
14
Initial experience with the 5 A9 300-mm Proteus embolic capture angioplasty balloon in the treatment of peripheral vascular disease. (23210883)
2012
15
Pretreatment of endothelial progenitor cells with osteopontin enhances cell therapy for peripheral vascular disease. (22304991)
2012
16
Polycystic ovary syndrome: a common endocrine disorder and risk factor for vascular disease. (21562798)
2011
17
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. (21069462)
2011
18
An option for intraoperative placement of an intra-aortic balloon pump in patients with occlusive peripheral vascular disease. (20633901)
2011
19
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. (20149485)
2011
20
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
21
The influence of basic ventilation strategies on cerebral oxygenation in anesthetized patients without vascular disease. (21061050)
2010
22
Non-invasive imaging of diabetic vascular disease. (21154315)
2010
23
The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease. (19724159)
2009
24
Versican degradation and vascular disease. (16839865)
2006
25
Percutaneous continuous aortic flow augmentation for cardiac recovery in a chronic heart failure patient with peripheral vascular disease. (17170590)
2006
26
Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped. (15654296)
2005
27
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (15051034)
2004
28
Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. (14998419)
2004
29
RHO SIGNALING in vascular diseases. (15616164)
2004
30
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. (12777673)
2003
31
Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. (12805074)
2003
32
Effects of cilostazol on serum lipid concentrations and plasma fatty acid composition in type 2 diabetic patients with peripheral vascular disease. (12624709)
2003
33
MR angiography for assessment of peripheral vascular disease. (12171187)
2002
34
Ethnic differences in peripheral vascular disease. (12425370)
2002
35
ABC of arterial and vascular disease. Secondary prevention of peripheral vascular disease. (10797042)
2000
36
ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients. (11124487)
2000
37
Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation. (10638832)
1999
38
Is clopidogrel markedly superior to aspirin in patients with peripheral vascular disease? (16793749)
1998
39
Renal vascular disease in the elderly. (9839288)
1998
40
Homocysteinemia: new information about an old risk factor for vascular disease. (10537928)
1998
41
Von Willebrand factor and soluble E-selectin in hyperlipidaemia: relationship to lipids and vascular disease. (9136912)
1997
42
Vascular permeability/vascular endothelial growth factors: a potential role in the pathogenesis and treatment of vascular diseases. (9552580)
1996
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. (8281664)
1994
45
Semiconductor diode laser photocoagulation in retinal vascular disease. (2255529)
1990
46
The tunable dye laser in the management of retinal vascular disease. (3229908)
1988
47
Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease. (3680515)
1987
48
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
49
Photocoagulation of retinal vascular disease. (4507180)
1972
50
Linear scleroderma with hemiatrophy: report of three cases associated with collagen-vascular disease. (5907143)
1966

Variations for Vascular Disease

About this section

Expression for genes affiliated with Vascular Disease

About this section
Search GEO for disease gene expression data for Vascular Disease.

Pathways for genes affiliated with Vascular Disease

About this section

Pathways related to Vascular Disease according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ACE, CST3
2
Show member pathways
Metalloproteases in connective tissue degradation
9.7SERPINE1, CST3, FGB
3
Show member pathways
9.7CETP, APOA2, ALB
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.6VCAM1, SELE, VEGFA
5
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.6APOA2, FGB, SERPINE1
69.5SELE, SELP, VCAM1
79.5VCAM1, SELP, SELE
8
Show member pathways
thioredoxin pathway36
9.3MTHFR, ALB, CRP, SERPINE1
9
Show member pathways
8.3FGB, PPBP, VEGFA, SERPINE1, SELP, ALB
10
Show member pathways
8.0PPBP, VEGFA, SERPINE1, SELE, SELP, ALB

Compounds for genes affiliated with Vascular Disease

About this section

Compounds related to Vascular Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1gliclazide43 49 1211.7VEGFA, SELE, VCAM1, ALB
2fosinopril43 1210.7SERPINE1, ACE, ALB, CRP
3telmisartan43 28 1211.6ACE, ALB, AGER, CRP
4hydrochlorothiazide43 28 49 24 1213.5ALB, SERPINE1, ACE, CRP
5ramipril43 1210.5SERPINE1, CST3, ALB, CRP, ACE
6kininogen439.5ALB, SERPINE1, CST3, SELP, ACE
7carvedilol43 49 28 1212.5ACE, SELE, VEGFA, VCAM1
8amlodipine43 49 24 1212.5VCAM1, SERPINE1, ACE, ALB
9perindopril43 49 1211.5SERPINE1, VEGFA, CRP, ALB, ACE
10metformin43 49 1211.4MTHFR, CRP, AGER, ACE, SERPINE1
11valsartan43 59 28 1212.4ACE, CRP, SELP, SERPINE1, ALB
12candesartan43 49 28 1212.3SERPINE1, SELP, ACE, VEGFA, ALB, AGER
13quinapril43 49 1211.3SERPINE1, SELE, SELP, ACE, CRP
14uric acid43 2410.3AGER, ALB, SERPINE1, CRP, CST3, MTHFR
15sele439.3SELP, VCAM1, ACE, CETP, SELE, MTHFR
16iohexol439.2CST3, SELP, PPBP, ALB
17alpha tocopherol439.2CETP, MTHFR, CRP, ALB, VCAM1
18folate439.2CRP, ALB, CST3, MTHFR, VCAM1, SELE
19methotrexate49 43 1211.1SERPINE1, ALB, CRP, SELE, CST3, MTHFR
208-isoprostane439.1CRP, VCAM1, SERPINE1, SELE
21cyclophosphamide43 49 1211.1SELE, VCAM1, CRP, VEGFA, MTHFR, SERPINE1
22warfarin43 49 24 1212.0SELP, MTHFR, PPBP, ALB, ACE
23n acetylcysteine438.8CRP, CST3, VCAM1, SELP, SELE, VEGFA
24mannitol43 129.8CRP, SERPINE1, VCAM1, SELP, ALB
25losartan43 49 28 1211.8SELP, SERPINE1, VCAM1, ACE, ALB, CRP
26fluvastatin43 49 28 1211.7VCAM1, CRP, ACE, CETP, SERPINE1, SELE
27simvastatin43 49 59 28 24 1213.7VEGFA, SERPINE1, CETP, CRP, SELE, VCAM1
28fenofibrate43 49 1210.6CRP, VCAM1, SELP, SERPINE1, APOA2, SELE
29rosiglitazone28 43 49 24 1212.6CRP, SERPINE1, SELE, VCAM1, ALB
30iloprost59 28 43 1211.6SELE, SELP, VCAM1, PPBP
31polysulfone438.5SELP, CRP, ALB, VCAM1, PPBP, CST3
32pravastatin43 49 28 24 1212.5SELE, SERPINE1, SELP, CETP, MTHFR, ACE
33atorvastatin43 49 28 24 1212.5SELP, VEGFA, CRP, ACE, CETP, VCAM1
34testosterone43 59 24 1211.5KLK15, ALB, SERPINE1, SELE, VCAM1, MTHFR
35aspartate438.3CETP, CST3, MTHFR, ALB, CRP, SELE
36aspirin43 49 28 2411.0PPBP, ACE, SERPINE1, SELE, SELP, CETP
37alanine437.8PPBP, SELE, VCAM1, CRP, ALB, CST3
38homocysteine43 248.8VCAM1, SELP, CETP, BHMT2, CRP, ALB
39lactate437.8CRP, CST3, SELE, SFTPD, PPBP, ALB
40prostacyclin437.7AGER, CRP, VCAM1, SELP, SELE, SERPINE1
41creatinine437.7ACE, MTHFR, SELP, SELE, SERPINE1, ALB
42vegf437.7SELE, VCAM1, AGER, CRP, CST3, SELP
43nitric oxide43 24 129.7SFTPD, SELE, VCAM1, ACE, AGER, SELP
44fibrinogen437.3PPBP, APOA2, SERPINE1, SELE, SELP, VCAM1
45cysteine437.2ALB, CST3, PPBP, SELP, VCAM1, CETP
46heparin43 28 24 1210.1PPBP, VEGFA, APOA2, SERPINE1, SELE, SELP
47lipid436.6ACE, CETP, VCAM1, PON2, SELE, SERPINE1
48glucose436.6VCAM1, PON2, ACE, PPBP, APOA2, SFTPD
49serine436.3SERPINE1, PPBP, VCAM1, CETP, MTHFR, RARRES2
50cholesterol43 28 24 129.1PPBP, SFTPD, APOA2, SERPINE1, AGER, CRP

GO Terms for genes affiliated with Vascular Disease

About this section

Cellular components related to Vascular Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.6APOA2, FGB, ALB
2high-density lipoprotein particleGO:00343649.6APOA2, CETP
3external side of plasma membraneGO:00098979.3SELP, VCAM1, ACE, FGB
4extracellular vesicular exosomeGO:00700628.7APOA2, CETP, ACE, ALB, BHMT2, CST3
5platelet alpha granule lumenGO:00310938.7PPBP, VEGFA, SERPINE1, ALB, FGB
6extracellular spaceGO:00056156.2PPBP, SFTPD, VEGFA, SERPINE1, SELE, SELP
7extracellular regionGO:00055765.7FGB, PPBP, SFTPD, VEGFA, APOA2, SERPINE1

Biological processes related to Vascular Disease according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1induction of positive chemotaxisGO:005093010.1AGER, VEGFA
2low-density lipoprotein particle remodelingGO:003437410.1CETP, APOA2
3surfactant homeostasisGO:004312910.0VEGFA, SFTPD
4methionine biosynthetic processGO:000908610.0BHMT2, MTHFR
5high-density lipoprotein particle remodelingGO:003437510.0CETP, APOA2
6positive regulation of leukocyte migrationGO:000268710.0SELP, SELE, VEGFA
7acute inflammatory responseGO:000252610.0VCAM1, APOA2
8negative regulation of macrophage derived foam cell differentiationGO:00107459.9CETP, CRP
9lipoprotein metabolic processGO:00421579.9APOA2, CETP, ALB
10cellular response to vascular endothelial growth factor stimulusGO:00359249.9VCAM1, VEGFA
11leukocyte tethering or rollingGO:00509019.8SELE, SELP, VCAM1
12leukocyte cell-cell adhesionGO:00071599.8VCAM1, SELP, SELE
13reverse cholesterol transportGO:00436919.8CETP, APOA2
14heterophilic cell-cell adhesionGO:00071579.8SELE, SELP, VCAM1
15positive regulation of receptor internalizationGO:00020929.7SELE, VEGFA
16response to hypoxiaGO:00016669.6CRP, MTHFR, VCAM1, VEGFA
17response to lipopolysaccharideGO:00324969.5SELE, SELP, VCAM1
18inflammatory responseGO:00069548.9SELE, SELP, CRP, RARRES2, AGER
19platelet degranulationGO:00025768.6FGB, ALB, SELP, SERPINE1, VEGFA, PPBP
20platelet activationGO:00301688.6PPBP, VEGFA, SERPINE1, SELP, ALB, FGB
21blood coagulationGO:00075968.4PPBP, VEGFA, SERPINE1, SELE, SELP, ALB

Molecular functions related to Vascular Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oligosaccharide bindingGO:00704929.9SELP, SELE
2lipid transporter activityGO:00053199.9CETP, APOA2
3sialic acid bindingGO:00336919.9SELP, SELE
4cholesterol transporter activityGO:00171279.8APOA2, CETP
5cholesterol bindingGO:00154859.6APOA2, CETP, CRP
6phosphatidylcholine bindingGO:00312109.6CETP, APOA2
7protein bindingGO:00055156.6FGB, SFTPD, VEGFA, APOA2, SERPINE1, SELE

Products for genes affiliated with Vascular Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Vascular Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet