MCID: VSC008
MIFTS: 30

Vascular Hemostatic Disease malady

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Vascular Hemostatic Disease

Aliases & Descriptions for Vascular Hemostatic Disease:

Name: Vascular Hemostatic Disease 12 14
Vascular Hemostatic Disorders 69
Hemostatic Disorders 42

Classifications:



External Ids:

Disease Ontology 12 DOID:484
MeSH 42 D020141
SNOMED-CT 64 21112004
UMLS 69 C0600502

Summaries for Vascular Hemostatic Disease

MalaCards based summary : Vascular Hemostatic Disease, also known as vascular hemostatic disorders, is related to thrombophilia due to activated protein c resistance and thrombophilia due to protein c deficiency, autosomal dominant. An important gene associated with Vascular Hemostatic Disease is KRIT1 (KRIT1, Ankyrin Repeat Containing), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Tranexamic Acid and Dalteparin have been mentioned in the context of this disorder. Related phenotype is embryo.

Related Diseases for Vascular Hemostatic Disease

Diseases related to Vascular Hemostatic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 thrombophilia due to activated protein c resistance 10.8
2 thrombophilia due to protein c deficiency, autosomal dominant 10.7
3 thrombophilia due to protein c deficiency, autosomal recessive 10.7
4 thrombophilia due to protein s deficiency, autosomal dominant 10.7
5 thrombophilia due to hrg deficiency 10.7
6 thrombophilia due to thrombomodulin defect 10.7
7 thrombophilia, x-linked, due to factor ix defect 10.7
8 thrombophilia due to antithrombin iii deficiency 10.7
9 thrombophilia due to heparin cofactor ii deficiency 10.7
10 alcoholic psychosis 10.3 KRIT1 SNRPB
11 paget's disease of bone 10.3 KRIT1 SNRPB
12 adult pineoblastoma 10.3 KRIT1 SNRPB
13 oxyphilic adenoma 10.2 F2 HBA1
14 tactile epilepsy 10.2 HBA1 KRIT1
15 subependymal glioma 10.2 F2 KRIT1
16 vascular erectile tumor 10.1 F2 SERPINC1
17 miller-dieker lissencephaly syndrome 10.1 F2 SERPINC1
18 influenza 10.1 F2 SERPINC1
19 freiberg's disease 10.1 F2 SERPINC1
20 pancreatic ductal carcinoma 10.1 F2 SERPINC1
21 mixed epithelial tumor of ovary 10.1 F2 SERPINC1
22 chorioretinal scar 10.1 F2 SERPINC1
23 mixed hepatoblastoma 10.1 F2 SERPINC1
24 peanut allergy 10.1 F2 SERPINC1
25 may-hegglin anomaly 10.1 F2 SERPINC1
26 left-right axis malformations 10.1 F2 SERPINC1
27 lymphocytic colitis 10.1 F2 SERPINC1
28 dmd-related dilated cardiomyopathy 10.1 F2 SERPINC1
29 spinal cord lipoma 10.1 F2 SERPINC1
30 midline cystocele 10.1 F2 SERPINC1
31 schwannoma of jugular foramen 10.1 F2 SERPINC1
32 bullous skin disease 10.1 F2 SERPINC1
33 neuroaxonal dystrophy 10.1 F2 SERPINC1
34 periosteal chondrosarcoma 10.1 F2 SERPINC1
35 angelucci's syndrome 10.1 F2 SERPINC1
36 hemopneumothorax 10.1 F2 HBA1 KRIT1
37 lynch syndrome 10.1 F2 SERPINC1
38 ductal carcinoma in situ 10.1 F2 SERPINC1
39 cryptosporidiosis 10.1 F2 SERPINC1
40 essential thrombocythemia 10.1 F2 SERPINC1
41 angular blepharoconjunctivitis 10.1 F2 SERPINC1
42 ovarian papillary cystadenoma 10.1 F2 SERPINC1
43 epstein-barr virus hepatitis 10.1 F2 SERPINC1
44 malignant hyperthermia susceptibility 1 10.1 CD2AP SERPINC1
45 eagle syndrome 10.1 F2 SERPINC1
46 blepharoconjunctivitis 10.1 F2 SERPINC1
47 intestinal disaccharidase deficiency 10.1 F2 SERPINC1
48 dysgammaglobulinemia 10.0 F2 SERPINC1
49 ophthalmia neonatorum 10.0 F2 SERPINC1
50 chondrodysplasia punctata 1, x-linked 10.0 CCM2 KRIT1 PDCD10

Graphical network of the top 20 diseases related to Vascular Hemostatic Disease:



Diseases related to Vascular Hemostatic Disease

Symptoms & Phenotypes for Vascular Hemostatic Disease

MGI Mouse Phenotypes related to Vascular Hemostatic Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.1 CCM2 CR1L F2 KRIT1 PDCD10 SERPINC1

Drugs & Therapeutics for Vascular Hemostatic Disease

Drugs for Vascular Hemostatic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1126)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1197-18-8 5526
2
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9041-08-1
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
4 Nadroparin Approved Phase 4,Phase 3 9041-08-1
5
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 179324-69-7 387447 93860
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
7
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
9
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
10
Zoledronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 118072-93-8 68740
11
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
12
Rivaroxaban Approved Phase 4,Phase 3,Phase 2,Phase 1 366789-02-8
13
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
14
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
15
Bivalirudin Approved, Investigational Phase 4,Phase 1 128270-60-0 16129704
16
Eptifibatide Approved, Investigational Phase 4 188627-80-7 123610
17
Octreotide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 83150-76-9 383414 6400441
18
Somatostatin Approved Phase 4,Phase 3,Phase 2 38916-34-6, 51110-01-1 53481605
19
Terlipressin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 14636-12-5 72081
20
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
21
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 73590-58-6 4594
22
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
23
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
24
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
25
Ethiodized oil Approved Phase 4,Phase 3,Phase 2 8008-53-5
26
Sorafenib Approved, Investigational Phase 4,Phase 2,Phase 1 284461-73-0 216239 406563
27
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2 103577-45-3 3883
28
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
29
Aminocaproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 60-32-2 564
30
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
31
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 137-58-6 3676
32
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
33
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2 59467-70-8 4192
34
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
35
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
36
Drospirenone Approved Phase 4 67392-87-4 68873
37
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
38
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
39
Tranylcypromine Approved Phase 4,Phase 3 155-09-9 441233
40
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741 24759
41
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
42
Warfarin Approved Phase 4,Phase 2,Phase 3,Phase 1 81-81-2 6691 54678486
43
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
44
Remifentanil Approved Phase 4 132875-61-7 60815
45
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
46
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
47
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
48
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
49
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
50
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189

Interventional clinical trials:

(show top 50) (show all 4685)
id Name Status NCT ID Phase
1 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4
2 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4
3 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4
4 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4
5 Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery Unknown status NCT01418521 Phase 4
6 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4
7 A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma Unknown status NCT01868828 Phase 4
8 Pseudohyponatremia of Multiple Myeloma is True Hyponatremia Unknown status NCT01425606 Phase 4
9 Stage I Multiple Myeloma Treatment Unknown status NCT00733538 Phase 4
10 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4
11 Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery Unknown status NCT01648712 Phase 4
12 Levonorgestrel-releasing Intrauterine Device on Obese Women: Effects on Hemostatic and Arterial Function Unknown status NCT01320917 Phase 4
13 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
14 Reversal of the Antithrombotic Action of New Oral Anticoagulants Unknown status NCT01478282 Phase 4
15 Radiofrequency Ablation Versus Hepatic Resection for the Treatment of Hepatocellular Carcinomas Smaller Than 2 cm Unknown status NCT01351194 Phase 4
16 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4
17 Percutaneous Radiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma Unknown status NCT01570166 Phase 4
18 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4
19 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
20 Effect of Doxium on High Sensitivity CRP and Endothelin-1 Serum Levels in Patients With Diabetic Retinopathy Unknown status NCT01382498 Phase 4
21 Peri-Procedural Myocardial Infarction, Platelet Reactivity, Thrombin Generation, and Clot Strength: Differential Effects of Eptifibatide + Bivalirudin Versus Bivalirudin Unknown status NCT00370045 Phase 4
22 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Unknown status NCT00966355 Phase 4
23 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4
24 Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT00861640 Phase 4
25 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4
26 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4
27 Transcatheter Arterial Chemoembolization Combined With Sorafenib for Unresectable Hepatocellular Carcinoma Unknown status NCT01833299 Phase 4
28 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
29 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
30 Transfusion Requirements in Gastrointestinal (GI) Bleeding Unknown status NCT00414713 Phase 4
31 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4
32 Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients Unknown status NCT02238288 Phase 4
33 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4
34 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
35 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4
36 Drainage Versus Sealant in Double Blinded Monocentric Open Incisional Hernia Repair Unknown status NCT00775034 Phase 4
37 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
38 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4
39 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Unknown status NCT00958581 Phase 4
40 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4
41 Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study Unknown status NCT01439997 Phase 4
42 Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction Unknown status NCT01582542 Phase 4
43 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4
44 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4
45 Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients Unknown status NCT02106962 Phase 4
46 Hemodilution and Coagulopathy With 3 Colloids Completed NCT01727830 Phase 4
47 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4
48 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4
49 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
50 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4

Search NIH Clinical Center for Vascular Hemostatic Disease

Cochrane evidence based reviews: hemostatic disorders

Genetic Tests for Vascular Hemostatic Disease

Anatomical Context for Vascular Hemostatic Disease

Publications for Vascular Hemostatic Disease

Variations for Vascular Hemostatic Disease

Expression for Vascular Hemostatic Disease

Search GEO for disease gene expression data for Vascular Hemostatic Disease.

Pathways for Vascular Hemostatic Disease

Pathways related to Vascular Hemostatic Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.94 C1QC F2 SERPINC1

GO Terms for Vascular Hemostatic Disease

Cellular components related to Vascular Hemostatic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 C1QC CD2AP F2 HBA1 PDCD10 SERPINC1
2 blood microparticle GO:0072562 8.92 C1QC F2 HBA1 SERPINC1

Biological processes related to Vascular Hemostatic Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein localization to nucleus GO:1900182 8.96 CD2AP F2
2 regulation of blood coagulation GO:0030193 8.62 F2 SERPINC1

Sources for Vascular Hemostatic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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