MCID: VSC047
MIFTS: 45

Vascular Malformation malady

Categories: Genetic diseases, Cardiovascular diseases

Aliases & Classifications for Vascular Malformation

Aliases & Descriptions for Vascular Malformation:

Name: Vascular Malformation 24

Classifications:



Summaries for Vascular Malformation

MalaCards based summary : Vascular Malformation is related to vascular malformation, primary intraosseous and clove syndrome, somatic. An important gene associated with Vascular Malformation is ELMO2 (Engulfment And Cell Motility 2), and among its related pathways/superpathways are Pathways in cancer and Androgen receptor signaling pathway. The drugs Heparin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and brain, and related phenotypes are behavior/neurological and embryo

Wikipedia : 71 Vascular malformation is a blood vessel abnormality. There are many types, but the most common is... more...

Related Diseases for Vascular Malformation

Diseases related to Vascular Malformation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
id Related Disease Score Top Affiliating Genes
1 vascular malformation, primary intraosseous 12.1
2 clove syndrome, somatic 11.8
3 phacomatosis pigmentovascularis 11.2
4 angiodysplasia 11.1
5 cerebral cavernous malformations-1 10.9
6 dieulafoy lesion 10.8
7 capillary malformation-arteriovenous malformation 10.8
8 sturge-weber syndrome, somatic, mosaic 10.8
9 capillary malformations, congenital, 1, somatic, mosaic 10.8
10 proteus syndrome, somatic 10.8
11 megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 10.8
12 extracranial arteriovenous malformation 10.7
13 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 10.7
14 hypertrophic olivary degeneration 10.7
15 hemangioma, capillary infantile 10.7
16 regional odontodysplasia 10.7
17 athabaskan brainstem dysgenesis syndrome 10.7
18 pulmonary surfactant protein b, deficiency of 10.2 ACVRL1 ENG
19 pulmonary venoocclusive disease 1 10.2 ACVRL1 ENG
20 tooth erosion 10.1 ACVRL1 ENG
21 joubert syndrome and related disorders 10.1 ACVRL1 ENG
22 weyers ulnar ray/oligodactyly syndrome 10.1 ACVRL1 ENG
23 intraneural perineurioma 10.1 ESR1 SLC2A1
24 mucoepidermoid esophageal carcinoma 10.1 ESR1 SLC2A1
25 hereditary hemorrhagic telangiectasia 10.1
26 perlman syndrome 10.1 ESR1 RAC1
27 nervous system hibernoma 10.1 AR ESR1
28 ulceroglandular tularemia 10.1 AR ESR1
29 anal neuroendocrine tumor 10.0 AR ESR1
30 hemangioma 10.0
31 osteogenesis imperfecta 10.0 AR ESR1
32 poliomyelitis 10.0 AR ESR1
33 middle ear adenocarcinoma 10.0 AR ESR1
34 carbuncle 10.0 AR ESR1
35 esophagus sarcoma 10.0 AR ESR1
36 vulva adenocarcinoma 10.0 AR ESR1
37 her2-receptor positive breast cancer 10.0 AR ESR1
38 glycerol kinase deficiency, adult form 10.0 ENG ESR1
39 capillary disease 10.0 AR ESR1
40 hepatitis 10.0
41 glomerulosclerosis, focal segmental, 7 10.0 ENG SMAD4
42 cerebritis 9.9
43 pituitary infarct 9.9 ACVRL1 ENG
44 acromesomelic dysplasia, maroteaux type 9.9 ACVRL1 SMAD4
45 congenital bile acid synthesis defect 9.9 AR ESR1
46 respiratory syncytial virus infectious disease 9.9 ACVRL1 ENG SMAD4
47 human venous malformation 9.8 ACVRL1 ENG SMAD4
48 endotheliitis 9.8
49 sydenham chorea 9.8 ACVRL1 ENG SMAD4
50 rhinitis 9.8 ESR1 SMAD4

Graphical network of the top 20 diseases related to Vascular Malformation:



Diseases related to Vascular Malformation

Symptoms & Phenotypes for Vascular Malformation

MGI Mouse Phenotypes related to Vascular Malformation:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 ENG ACVRL1 ESR1 AR SLC2A1 SMAD4
2 embryo MP:0005380 10 ESR1 AR RAC1 ENG ACVRL1 SLC2A1
3 cardiovascular system MP:0005385 9.99 ACVRL1 ESR1 AR RAC1 ENG SMAD4
4 growth/size/body region MP:0005378 9.98 ESR1 AR RAC1 ENG ACVRL1 SLC2A1
5 homeostasis/metabolism MP:0005376 9.91 ACVRL1 ESR1 AR ENG RAC1 SLC2A1
6 craniofacial MP:0005382 9.89 AR RAC1 ENG ACVRL1 SMAD4
7 digestive/alimentary MP:0005381 9.88 ESR1 AR ENG ACVRL1 SMAD4
8 hematopoietic system MP:0005397 9.88 ENG ACVRL1 ESR1 AR RAC1 SMAD4
9 mortality/aging MP:0010768 9.8 ACVRL1 ESR1 AR ENG RAC1 SLC2A1
10 integument MP:0010771 9.72 ESR1 AR ENG RAC1 SMAD4
11 muscle MP:0005369 9.63 ESR1 AR RAC1 ENG ACVRL1 SMAD4
12 nervous system MP:0003631 9.5 ESR1 AR RAC1 ENG ACVRL1 SLC2A1
13 normal MP:0002873 9.02 ENG ACVRL1 ESR1 AR SMAD4

Drugs & Therapeutics for Vascular Malformation

Drugs for Vascular Malformation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 767)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
2
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
4
Dipyridamole Approved Phase 4,Phase 3 58-32-2 3108
5
Ramipril Approved Phase 4,Phase 3 87333-19-5 5362129
6
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
7
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 78919-13-8 6443959
8
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147536-97-8 104865
9
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 58-61-7 60961
10
Regadenoson Approved Phase 4,Phase 2 313348-27-5 219024
11
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
12
Sevelamer Approved Phase 4 52757-95-6, 152751-57-0 3085017
13
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
14
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
15
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
16
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 2078-54-8 4943
17
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
18
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
19
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
20
Ethanol Approved Phase 4,Phase 2,Phase 1 64-17-5 702
21
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
22
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
23
Verapamil Approved Phase 4 52-53-9 2520
24
Celiprolol Approved, Investigational Phase 4 56980-93-9
25
Nicardipine Approved Phase 4 55985-32-5 4474
26
Nifedipine Approved Phase 4 21829-25-4 4485
27
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
28
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
29
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
30
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3 58-93-5 3639
31
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
32
Eplerenone Approved Phase 4 107724-20-9 150310 443872
33
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
34
Nitroglycerin Approved, Investigational Phase 4,Phase 3 55-63-0 4510
35
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-84-3 187
36
Cilostazol Approved Phase 4 73963-72-1 2754
37
Adalimumab Approved Phase 4 331731-18-1 16219006
38
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
39
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
40
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
41
Mechlorethamine Approved Phase 4,Phase 2 51-75-2 4033
42
Remifentanil Approved Phase 4,Phase 1 132875-61-7 60815
43
Cilnidipine Approved Phase 4 132203-70-4 5282138
44
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 564-25-0 54671203
45
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2 171596-29-5 110635
46
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
47
Ticagrelor Approved Phase 4,Phase 1,Phase 2 274693-27-5 9871419
48
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
49
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
50
Calcium carbonate Approved Phase 4 471-34-1

Interventional clinical trials:

(show top 50) (show all 1344)
id Name Status NCT ID Phase
1 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4
2 Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients Unknown status NCT02106962 Phase 4
3 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4
4 Curcumin for Type 2 Diabetic Patients Unknown status NCT01052597 Phase 4
5 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4
6 Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD Unknown status NCT02008786 Phase 4
7 Lovaza Mechanisms of Action Unknown status NCT01301794 Phase 4
8 Improved Diagnosis of Congenital Heart Disease by Magnetic Resonance Imaging Using Vasovist Unknown status NCT00668824 Phase 4
9 Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Unknown status NCT01550588 Phase 4
10 Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart Disease Unknown status NCT01383083 Phase 4
11 Diagnostic Benefits of HyperQTM vs. Conventional ECG Stress Test. Comparison of HyperQ vs. Stress ECG in Women Before Angiography Unknown status NCT00850486 Phase 4
12 Lexiscan(TM) Rb-82 Myocardial Perfusion PET: A Comparison With Dipyridamole Stress Unknown status NCT00808314 Phase 4
13 Microvascular Reperfusion Utilizing Sonothrombolysis in Acute Myocardial Infarction (MRUSMI TRIAL) Unknown status NCT02170103 Phase 4
14 PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Unknown status NCT00166257 Phase 4
15 Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia Completed NCT00230659 Phase 4
16 Effects of Heparin on Arteriovenous Fistula Patency Completed NCT02493504 Phase 4
17 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4
18 The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas Completed NCT01685710 Phase 4
19 The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study. Completed NCT01270087 Phase 4
20 Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis Completed NCT01133054 Phase 4
21 Molecular Mechanisms of Type 2 Diabetes Mellitus Completed NCT00816218 Phase 4
22 Evaluation of Cilostazol in Combination With L-Carnitine Completed NCT00822172 Phase 4
23 Celiprolol in Patients With Ehlers-Danlos Syndrome, Vascular Type Completed NCT00190411 Phase 4
24 CARDIOLITE-413: A Study for Patients Who Had a PCI for an Acute MI Completed NCT00162331 Phase 4
25 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
26 Low Dose One-Day Tc99m Protocol With a High-Efficiency Cardiac Dedicated Gamma Camera For Detection of Coronary Disease Completed NCT01135095 Phase 4
27 A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Completed NCT02596048 Phase 4
28 Effect of 5 Years of GH Replacement on Atherosclerosis Completed NCT00462475 Phase 4
29 Intravitreal Macugen for Ischaemic Diabetic Macular Oedema Completed NCT01175070 Phase 4
30 Effect of Magnesium Administration in Subjects With Family History of Diabetes or Metabolic Syndrome Completed NCT01181830 Phase 4
31 The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil Completed NCT03144596 Phase 4
32 Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes Completed NCT02019186 Phase 4
33 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
34 Eplerenone in Systemic Right Ventricle Completed NCT00703352 Phase 4
35 Comparison of Medical Therapies in Marfan Syndrome. Completed NCT01295047 Phase 4
36 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4
37 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
38 Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology Completed NCT00317486 Phase 4
39 Bosentan in Treatment of Pulmonary Arterial Hypertension Completed NCT00266162 Phase 4
40 Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS) Completed NCT00371891 Phase 4
41 Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM) Completed NCT01588470 Phase 4
42 The Effects of Cilnidipine on Metabolic Syndrome Improvement Completed NCT00325936 Phase 4
43 Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Patients With Slight Hypertension and Target Organ Damage Completed NCT00687206 Phase 4
44 Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction Completed NCT00222573 Phase 4
45 High-sensitivity Troponin in Cardiac Surgery Completed NCT01913873 Phase 4
46 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
47 Ticagrelor China Pharmacokinetic/Pharmacodynamic Study Completed NCT02064985 Phase 4
48 BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Physiology Completed NCT00367770 Phase 4
49 FREE Study - Fracture Reduction Evaluation Completed NCT00211211 Phase 4
50 The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability Completed NCT01634594 Phase 4

Search NIH Clinical Center for Vascular Malformation

Genetic Tests for Vascular Malformation

Genetic tests related to Vascular Malformation:

id Genetic test Affiliating Genes
1 Vascular Malformation 24

Anatomical Context for Vascular Malformation

MalaCards organs/tissues related to Vascular Malformation:

39
Liver, Endothelial, Brain, Heart, Lung, Monocytes, Hypothalamus

Publications for Vascular Malformation

Articles related to Vascular Malformation:

(show top 50) (show all 191)
id Title Authors Year
1
Awake Surgery for Brain Vascular Malformations and Moyamoya Disease. ( 28377246 )
2017
2
Balloon-Occluded Retrograde Transvenous Obliteration of a Gastric Vascular Malformation: An Innovative Approach to Treatment of a Rare Condition. ( 27671152 )
2017
3
Oral encapsulated vascular malformation: An undescribed presentation in the mouth. ( 26855712 )
2016
4
Ex Vivo Resection and Renal Autotransplantation for the Treatment of a Large Renal Vein Aneurysm Causing Recurrent Pulmonary Embolism and a Coexisting Vascular Malformation: A Case Report. ( 27334478 )
2016
5
HIF-1I+ and HIF-2I+ induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide. ( 27249651 )
2016
6
Vasa Nervorum Feeders of Vascular Malformation. ( 27338499 )
2016
7
Thermographic Assessment of a Vascular Malformation of the Hand: A New Imaging Modality. ( 27195175 )
2016
8
Net-like Superficial Vascular Malformation: Clinical Description and Evidence for Lymphatic Origin. ( 26800314 )
2016
9
A Vascular Malformation Invading the Medial Plantar Nerve. ( 26802056 )
2016
10
Effects of physiotherapy combined with sirolimus in a patient with vascular malformation: A case report. ( 27976563 )
2016
11
A Vascular Malformation Presenting as a Peripheral Nerve Sheath Tumor. ( 28077959 )
2016
12
Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling. ( 27476657 )
2016
13
Spontaneous Cystic Penile Vascular Malformation in an Adolescent and Review of the Literature. ( 27112512 )
2016
14
High-Flow Vascular Malformation in the Sigmoid Mesentery Successfully Treated with a Combination of Transarterial and Transvenous Embolization. ( 27456690 )
2016
15
Bleeding recurrence in patients with gastrointestinal vascular malformation after thalidomide. ( 27537596 )
2016
16
Letter to the Editor: Vascular tumor versus vascular malformation of the internal auditory canal. ( 27419829 )
2016
17
Optic chiasmal cavernous angioma: A rare suprasellar vascular malformation. ( 27583178 )
2016
18
Low-Flow Vascular Malformation Pitfalls: From Clinical Examination to Practical Imaging Evaluation--Part 1, Lymphatic Malformation Mimickers. ( 26999565 )
2016
19
Natural history of brain capillary vascular malformations in hereditary hemorrhagic telangiectasia patients. ( 26919971 )
2016
20
Intravascular Myopericytoma of the Plantar Region: Case Report and Discussion of the Probable Origin From a Cutaneous Vascular Malformation. ( 26959697 )
2016
21
Coexistence of splenic hemangioma and vascular malformation of the vertebrae. ( 26860733 )
2016
22
A digital vascular malformation masquerading as synovitis. ( 26815764 )
2016
23
A rare atypical rapidly involuting congenital hemangioma combined with vascular malformation in the upper limb. ( 27565546 )
2016
24
Successful Treatment of a Complex Vascular Malformation With Sirolimus and Surgical Resection. ( 27820120 )
2016
25
Vascular Steal Syndrome, Optic Neuropathy, and Foreign Body Granuloma Reaction to Onyx-18 Embolization for Congenital Orbito-Facial Vascular Malformation. ( 27239463 )
2016
26
Venolymphatic vascular malformation of the parotid gland extending into the parapharyngeal space: A rare presentation. ( 27601828 )
2016
27
Angiolymphoid Hyperplasia With Eosinophilia Within a Vascular Malformation: Case Report and Review of the Literature. ( 27141028 )
2016
28
Resection and Advancement Flap Closure of a Combined Vascular Malformation of the Mons Pubis. ( 26942353 )
2016
29
Low-Flow Vascular Malformation Pitfalls: From Clinical Examination to Practical Imaging Evaluation--Part 2, Venous Malformation Mimickers. ( 26999647 )
2016
30
Orbital infarction syndrome after multiple percutaneous sclerotherapy sessions for facial low-flow vascular malformation: A case report and literature review. ( 27688283 )
2016
31
A congenital localised reticular vascular malformation. ( 27044260 )
2016
32
Benign Vascular Malformation at the Ischial Tuberosity. ( 27363574 )
2016
33
Proptosis Reduction Using Sirolimus in a Child With an Orbital Vascular Malformation and Blue Rubber Bleb Nevus Syndrome. ( 27065430 )
2016
34
Linear Multiple Epithelioid Hemangioma Associated With a Quiescent Vascular Malformation. ( 27491872 )
2016
35
A long-Segmental Vascular Malformation in the Small Bowel Presenting With Gastrointestinal Bleeding in a Preschool-Aged Child. ( 27110342 )
2016
36
Assessment of PTEN-associated vascular malformations in a patient with Bannayan-Riley-Ruvalcaba syndrome. ( 27358095 )
2016
37
Role of endovascular embolization for trigeminal neuralgia related to cerebral vascular malformation. ( 27402800 )
2016
38
A rare newly described overgrowth syndrome with vascular malformations-Cloves syndrome. ( 25709171 )
2015
39
The Dural AV-Fistula (DAVF), the Most Frequent Acquired Vascular Malformation of the Central Nervous System (CNS). ( 26308245 )
2015
40
Vascular malformation with phleboliths involving the parotid gland: A case report with a review of the literature. ( 26535823 )
2015
41
Glossectomy in the severe maxillofacial vascular malformation with jaw deformity: a rare case report. ( 26609517 )
2015
42
The V Sign: Tenting of the Globe From a Vascular Malformation. ( 25839838 )
2015
43
Angiographically occult vascular malformation of the intracranial accessory nerve: case report. ( 26566204 )
2015
44
High-flow vascular malformation treatment using ultrasound-guided laser combined with polidocanol sclerotherapy. ( 26576799 )
2015
45
The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. ( 25847705 )
2015
46
Sclerotherapy using 1% sodium tetradecyl sulfate to treat a vascular malformation: a report of two cases. ( 26734559 )
2015
47
Topical rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial. ( 25455610 )
2015
48
Nonsurgical management of vascular malformation of masseter. ( 25961625 )
2015
49
Venous vascular malformation of the floor of mouth masquerading as a dermoid tumor. ( 26851131 )
2015
50
Intraoperative Angiography Using Portable Fluoroscopy Unit in the Treatment of Vascular Malformation. ( 26041625 )
2015

Variations for Vascular Malformation

Expression for Vascular Malformation

Search GEO for disease gene expression data for Vascular Malformation.

Pathways for Vascular Malformation

GO Terms for Vascular Malformation

Cellular components related to Vascular Malformation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.8 AR ESR1 SMAD4

Biological processes related to Vascular Malformation according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 ACVRL1 AR ESR1 SMAD4
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.85 ACVRL1 AR ENG ESR1 SMAD4
3 protein deubiquitination GO:0016579 9.77 AR ESR1 SMAD4
4 in utero embryonic development GO:0001701 9.76 ACVRL1 AR SMAD4
5 negative regulation of gene expression GO:0010629 9.73 ACVRL1 ENG ESR1
6 steroid hormone mediated signaling pathway GO:0043401 9.61 AR ESR1
7 intracellular receptor signaling pathway GO:0030522 9.61 AR ESR1
8 cellular response to BMP stimulus GO:0071773 9.59 ACVRL1 SMAD4
9 male gonad development GO:0008584 9.58 AR ESR1 SMAD4
10 outflow tract septum morphogenesis GO:0003148 9.57 ENG SMAD4
11 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.55 ENG SMAD4
12 mammary gland alveolus development GO:0060749 9.54 AR ESR1
13 epithelial cell morphogenesis GO:0003382 9.52 AR RAC1
14 endocardial cushion morphogenesis GO:0003203 9.51 ACVRL1 ENG
15 BMP signaling pathway GO:0030509 9.5 ACVRL1 ENG SMAD4
16 uterus development GO:0060065 9.49 ESR1 SMAD4
17 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.48 ENG SMAD4
18 seminiferous tubule development GO:0072520 9.43 AR SMAD4
19 dorsal aorta morphogenesis GO:0035912 9.37 ACVRL1 ENG
20 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.33 ACVRL1 ENG SMAD4
21 response to transforming growth factor beta GO:0071559 9.26 ENG SMAD4
22 endocardial cushion to mesenchymal transition GO:0090500 8.96 ACVRL1 ENG
23 positive regulation of BMP signaling pathway GO:0030513 8.8 ACVRL1 ENG SMAD4

Molecular functions related to Vascular Malformation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.65 AR ESR1 RAC1
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.61 AR ESR1 SMAD4
3 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.5 AR ESR1 SMAD4
4 steroid hormone receptor activity GO:0003707 9.46 AR ESR1
5 RNA polymerase II transcription factor binding GO:0001085 9.4 AR SMAD4
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.37 AR ESR1
7 steroid binding GO:0005496 9.26 AR ESR1
8 transforming growth factor beta binding GO:0050431 9.16 ACVRL1 ENG
9 activin binding GO:0048185 8.96 ACVRL1 ENG
10 ATPase binding GO:0051117 8.8 AR ESR1 RAC1

Sources for Vascular Malformation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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