MCID: VSC011
MIFTS: 57

Vasculitis malady

Rare diseases, Cardiovascular diseases categories

Aliases & Classifications for Vasculitis

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Vasculitis, Aliases & Descriptions:

Name: Vasculitis 9 41 11 43 32 60
Autoimmune Vasculitis 41 60
Angiitis 9 41
 
Vasculitis, Autoimmune 41
Systemic Vasculitis 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:865
NCIt38 C26912
MeSH33 D014657

Summaries for Vasculitis

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MedlinePlus:32 Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. it can happen because of an infection, a medicine, or another disease. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges. the bulge is called an aneurysm. if it bursts, it can cause dangerous bleeding inside the body. symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute

MalaCards based summary: Vasculitis, also known as autoimmune vasculitis, is related to retinal vasculitis and lupus erythematosus. An important gene associated with Vasculitis is SELE (selectin E), and among its related pathways are Cellular roles of Anthrax toxin and Thromboxane A2 receptor signaling. The drug pentoxifylline and the compounds apocynin and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, endothelial and lung, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A vascular disease that is characterized by inflammation of the blood vessels.

NIH Rare Diseases:41 Vasculitis is an inflammation of the vascular system, which includes the veins, arteries, and capillaries. there are many different forms of vasculitis, including temporal arteritis, primary angiitis of the central nervous system, takayasu disease, periarteritis nodosa, kawasaki disease, churg-strauss syndrome, wegener granulomatosis, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, sjogren syndrome, behcet disease and others. signs and symptoms of vasculitis vary depending on the form and on the part of the body affected. in general, the cause of vasculitis is thought to be a faulty immune system response. treatment of vasculitis depends upon the specific diagnosis. most of forms of vasculitis respond well to steroid drugs. some may also require treatment with an immunosuppressive drug, such as cyclophosphamide. last updated: 3/12/2009

Wikipedia:63 Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation.... more...

Related Diseases for Vasculitis

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Diseases related to Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 665)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis32.2SAG, APOH
2lupus erythematosus31.6APOH, IFNA2
3rheumatoid vasculitis31.6LTF, VCAM1, SELE, ICAM1
4systemic lupus erythematosus31.5FCGR3B, CRP
5purpura31.4CD79A
6hepatitis c31.3TNF, IFNA2, LTF
7cryoglobulinemia31.3CD79A, APOH, IFNA2
8churg-strauss syndrome31.1MPO, LTF, PRTN3
9retinal artery occlusion31.1APOH
10hypersensitivity vasculitis31.0MPO, FCGR3B, CD79A, PRTN3
11polyarteritis nodosa31.0LTF, IFNA2, PRTN3, MPO
12rapidly progressive glomerulonephritis31.0ICAM1, MPO, PRTN3
13uveitis31.0TNF, SAG, ICAM1, IFNA2
14glomerulonephritis30.9VCAM1, MPO, CD79A, PRTN3, ICAM1
15scleritis30.9PRTN3
16mononeuritis multiplex30.9PRTN3, MPO
17mixed connective tissue disease30.8APOH, PRTN3
18colitis30.8TNF, MPO, LTF
19mononeuropathy30.8MPO, PRTN3
20wegener granulomatosis30.8PRTN3, MPO, SELE
21endophthalmitis30.8SAG
22degos disease30.8APOH
23crohn's disease30.8CRP, TNF, LTF
24panuveitis30.8IFNA2
25endocarditis30.8PRTN3
26peripheral vascular disease30.8SELE, VCAM1
27kawasaki disease30.7CRP, SELE
28polymyositis30.7VCAM1, SELE, ICAM1
29chickenpox30.7CD79A
30rheumatic disease30.7TNF, CRP, APOH
31syphilis30.5CD79A, APOH
32thyroiditis30.5CD79A
33membranoproliferative glomerulonephritis30.5IFNA2, CD79A
34henoch-schoenlein purpura30.5VCAM1, CD79A, ICAM1, MPO
35lupus nephritis30.5APOH, VCAM1, ICAM1, CD79A
36ulcerative colitis30.5PRTN3, LTF, CRP, TNF
37vascular disease30.4TNF, APOH, ITGAM
38pustulosis palmaris et plantaris30.4SELE
39dermatitis30.4CD79A, ICAM1, SELE, VCAM1
40graves' disease30.4MPO, ICAM1, VCAM1, SELE
41rheumatic fever30.4CRP
42psoriatic arthritis30.4TNF, CRP, SELE
43goodpasture syndrome30.3VCAM1, MPO
44granulocytopenia30.3ITGAM, MPO
45leukocyte adhesion deficiency30.3ITGAM
46antiphospholipid syndrome30.3APOH, SELE, VCAM1, CD79A
47pancreatitis30.3ICAM1, MPO, CRP, LTF
48chorioamnionitis30.3LTF, CRP, TNF
49psoriasis30.3SELE, TNF, ICAM1, VCAM1, LTF
50acute respiratory distress syndrome30.2TNF, SELE

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to vasculitis

Symptoms for Vasculitis

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Drugs & Therapeutics for Vasculitis

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Drug clinical trials:

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Search NIH Clinical Center for Vasculitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Vasculitis

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Anatomical Context for Vasculitis

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MalaCards organs/tissues related to Vasculitis:

31
Neutrophil, Endothelial, Lung, T cells, Heart, Skin, B cells, Kidney, Brain, Liver, Thyroid, Monocytes, Eye, Bone, Testes, Spinal cord, Breast, Bone marrow, Salivary gland, Myeloid, Retina, Prostate, Lymph node, Skeletal muscle, Small intestine, Colon, Uterus, Cervix, Pituitary

Animal Models for Vasculitis or affiliated genes

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MGI Mouse Phenotypes related to Vasculitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.7CD79A, CRP, ITGAM, ICAM1, VCAM1, SELE
2MP:00053975.6SH2D1A, MPO, SELE, VCAM1, PRTN3, ICAM1
3MP:00053875.5PRTN3, CD79A, CRP, ITGAM, ITGAX, ICAM1

Publications for Vasculitis

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Articles related to Vasculitis:

(show top 50)    (show all 2319)
idTitleAuthorsYear
1
Finger necrosis due to cryoglobulinemic vasculitis in association with membranous nephropathy. (25552807)
2015
2
Biological drugs in ANCA-associated vasculitis. (25907243)
2015
3
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. (25425493)
2015
4
Cutaneous vasculitis overlap with acute generalised exanthematous pustulosis (AGEP). (25404248)
2014
5
The case for cost-effectively treating cryoglobulinemic vasculitis with interferon-free anti-hepatitis C virus therapy. (25380535)
2014
6
Failure of Recombinant Activated Factor VII in Treatment of Diffuse Alveolar Hemorrhage due to Cryoglobulinemic Vasculitis. (25114814)
2014
7
Perfusion and spectroscopy magnetic resonance imaging in a case of lymphocytic vasculitis mimicking brain tumor. (24115963)
2013
8
The outcomes of patients with ESRD and ANCA-associated vasculitis in Australia and New Zealand. (23349331)
2013
9
Headache and vasculitis. (23338772)
2013
10
Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis. (22962314)
2013
11
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
12
Cocaine induced vasculitis: have we found a culprit? (23346447)
2012
13
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
14
Cutaneous vasculitis induced by TNF inhibitors: a report of three cases. (19812889)
2010
15
Hypersensitivity vasculitis associated with leuprolide (Lupron). (20470239)
2010
16
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (19714622)
2009
17
Necrotizing lymphocytic vasculitis limited to the peripheral nerves: report of six cases and review. (20204175)
2009
18
Rickettsia sibirica subsp. mongolitimonae infection and retinal vasculitis. (18394301)
2008
19
Antigen-specific ANCA ELISAs have different sensitivities for active and treated vasculitis and for nonvasculitic disease. (18089488)
2008
20
Is carotidynia syndrome a subset of vasculitis? (18785305)
2008
21
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
22
The role of biologic therapies in the management of systemic vasculitis. (16697969)
2006
23
SIR 2004 film panel case: Primary hyperoxaluria type I mimicking arterial vasculitis--a lethal disease. (15361574)
2004
24
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. (15160961)
2004
25
Degos' disease mimicking vasculitis. (15188339)
2004
26
Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis. (14693016)
2004
27
Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. (14740443)
2003
28
Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis. (12685871)
2002
29
Cerebrospinal fluid neurofilament and glial fibrillary acidic protein in patients with cerebral vasculitis. (11891800)
2002
30
Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)
2002
31
Tissue targeting and disease patterns in systemic vasculitis. (11469821)
2001
32
Limited cutaneous systemic sclerosis associated with MPO-ANCA positive renal small vessel vasculitis of the microscopic polyangiitis type. (10977809)
2000
33
Leukocytoclastic vasculitis in a child with epidermolysis bullosa simplex. (10770671)
1999
34
New concepts in treatment protocols for severe systemic vasculitis. (9894629)
1999
35
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
36
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
37
Myeloperoxidase antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in a very elderly patient with generalized vasculitis at autopsy. (9353970)
1997
38
Alpha-1-antitrypsin phenotyping in ANCA-associated diseases: one of several arguments for protease/antiprotease imbalance in systemic vasculitis. (9493789)
1997
39
Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (8697616)
1996
40
ANCA-associated forms of vasculitis]. (9065053)
1996
41
Reduced red blood cell deformability in patients with rheumatoid vasculitis. Improvement after in vitro treatment with dipyridamole. (7848316)
1995
42
ANCA and predicting relapse in systemic vasculitis. (7704563)
1995
43
Pro- and anti-inflammatory cytokines in primary systemic vasculitis. (8296631)
1993
44
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
45
Elimination diet in the treatment of selected patients with hypersensitivity vasculitis. (1505105)
1992
46
Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. (1791222)
1991
47
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986
48
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
49
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
50
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982

Variations for Vasculitis

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Expression for genes affiliated with Vasculitis

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Search GEO for disease gene expression data for Vasculitis.

Pathways for genes affiliated with Vasculitis

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Pathways related to Vasculitis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0VCAM1, TNF
29.8ICAM1, VCAM1, SELE
3
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.8SELE, VCAM1, ICAM1
49.8ICAM1, VCAM1, TNF
59.8TNF, VCAM1, ICAM1
69.5ICAM1, VCAM1, SELE, TNF
79.5TNF, SELE, VCAM1, ICAM1
89.5TNF, SELE, VCAM1, ICAM1
99.5ICAM1, VCAM1, MPO, TNF
109.4VCAM1, ICAM1, ITGAM
119.4VCAM1, ICAM1, ITGAM
12
Show member pathways
thioredoxin pathway36
9.4TNF, MPO, ICAM1, CRP
13
Show member pathways
9.2IFNA2, ICAM1, SH2D1A, TNF
149.2ITGAM, ICAM1, FCGR3B
15
Show member pathways
9.2TNF, FCGR3B, ITGAM
169.2ITGAM, FCGR3B, MPO
179.2SELE, VCAM1, ICAM1, ITGAM
18
Show member pathways
9.1ITGAM, ITGAX, SELE
199.1TNF, MPO, ICAM1, ITGAM
209.0CD79A, VCAM1, MPO, SH2D1A
21
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.0ITGAX, ITGAM, CRP
228.9FCGR3B, ITGAX, ITGAM
23
Show member pathways
8.9ITGAM, ITGAX, ICAM1, VCAM1
248.9ITGAM, ITGAX, ICAM1, VCAM1
25
Show member pathways
8.9ITGAM, ITGAX, ICAM1, VCAM1
26
Show member pathways
Immune response CD16 signaling in NK cells58
8.8TNF, SH2D1A, FCGR3B, ICAM1, IFNA2
27
Show member pathways
8.8SELE, IFNA2, ITGAX, ITGAM
288.3TNF, FCGR3B, IFNA2, ITGAX, ITGAM

Compounds for genes affiliated with Vasculitis

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Compounds related to Vasculitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1apocynin43 5910.6ICAM1, TNF, MPO, VCAM1, SELE
2polymyxin b439.5SELE, VCAM1, TNF, LTF, ICAM1
3gliclazide43 49 1211.5VCAM1, ICAM1, SELE, MPO
4hydroxychloroquine43 1210.5IFNA2, CRP, APOH, TNF
5budesonide43 49 1211.5LTF, ICAM1, MPO, TNF, VCAM1
6fenofibrate43 49 1211.4CRP, SELE, VCAM1, ICAM1, TNF
7dextran sulfate439.3APOH, MPO, SELE, ICAM1, LTF
8etanercept43 49 1211.2CRP, APOH, TNF, FCGR3B, IFNA2
9okt3439.1TNF, SELE, CD79A, VCAM1, ICAM1, CRP
108-isoprostane439.1ICAM1, TNF, APOH, MPO, SELE, VCAM1
11sulfasalazine28 43 49 1212.0CD79A, ICAM1, MPO, TNF, CRP, SELE
12methacholine43 49 1211.0MPO, ICAM1, CRP, LTF, CD79A
13ivig438.9TNF, APOH, SAG, CRP, CD79A
14polyethylene glycol438.9ICAM1, MPO, CD79A, SELE, IFNA2, CRP
15prostacyclin438.9SELE, ICAM1, LTF, CRP, VCAM1, APOH
16pdtc438.9VCAM1, SELE, ITGAX, TNF, ICAM1
17pentoxifylline43 129.9ICAM1, TNF, ITGAM, VCAM1, MPO, LTF
18atorvastatin43 49 28 24 1212.9SELE, ICAM1, CRP, TNF, ITGAM, VCAM1
19simvastatin43 49 59 28 24 1213.8SELE, ITGAM, TNF, CRP, ICAM1, VCAM1
20cyclophosphamide43 49 1210.8VCAM1, MPO, IFNA2, LTF, CRP, APOH
21neopterin438.8CRP, LTF, CD79A, IFNA2, ICAM1, TNF
22vitamin b12438.8LTF, APOH, MPO, CRP, CD79A
23cytochalasin b438.7FCGR3B, ICAM1, PRTN3, MPO, LTF
24infliximab43 49 1210.6PRTN3, SELE, APOH, TNF, CRP, IFNA2
25leukotriene b443 59 2410.4TNF, MPO, ITGAX, ITGAM, LTF, FCGR3B
26endotoxin438.3LTF, CRP, ITGAM, ICAM1, VCAM1, SELE
27polysaccharide438.2ITGAM, CD79A, LTF, VCAM1, SELE, FCGR3B
28azathioprine43 2 49 1211.2LTF, CD79A, APOH, PRTN3, IFNA2, CRP
29ascorbic acid43 249.1CD79A, CRP, MPO, ICAM1, IFNA2, LTF
30mannose438.0CD79A, APOH, FCGR3B, ITGAX, ITGAM, LTF
31rituximab43 49 1210.0CD79A, CRP, IFNA2, TNF, APOH, FCGR3B
32indomethacin43 28 59 1210.9ITGAM, LTF, TNF, MPO, IFNA2, ITGAX
33phosphatidylserine43 28 129.9FCGR3B, PRTN3, CD79A, LTF, APOH, SELE
34lactate437.9VCAM1, ICAM1, ITGAM, CRP, MPO, CD79A
35pge2437.9ICAM1, MPO, TNF, ITGAM, CD79A, VCAM1
36histamine43 28 249.9ITGAM, LTF, CD79A, IFNA2, ICAM1, VCAM1
37n acetylcysteine437.8VCAM1, TNF, MPO, SELE, LTF, CD79A
38genistein43 28 59 2 24 1212.8ITGAM, ICAM1, PRTN3, VCAM1, SELE, FCGR3B
39prednisolone43 28 129.7MPO, APOH, CRP, CD79A, TNF, FCGR3B
40heparin43 28 24 1210.5LTF, VCAM1, APOH, MPO, SELE, SAG
41nitric oxide43 24 129.5MPO, ITGAM, ITGAX, ICAM1, TNF, APOH
42n-formylmethionyl-leucylphenylalanine437.4ITGAM, PRTN3, ITGAX, ICAM1, FCGR3B, MPO
43alanine437.3IFNA2, CRP, CD79A, VCAM1, PRTN3, LTF
44fibrinogen437.3SELE, ICAM1, ITGAX, ITGAM, CD79A, LTF
45vegf437.2APOH, MPO, VCAM1, ICAM1, IFNA2, ITGAM
46fmlp437.2ITGAX, TNF, MPO, ITGAM, LTF, ICAM1
47lipid437.0CRP, APOH, SELE, SAG, TNF, FCGR3B
48oxygen43 248.0PRTN3, SAG, VCAM1, IFNA2, APOH, TNF
49superoxide43 247.8FCGR3B, PRTN3, TNF, APOH, LTF, ITGAM
50retinoic acid43 247.7LTF, ITGAM, MPO, VCAM1, PRTN3, ITGAX

GO Terms for genes affiliated with Vasculitis

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Cellular components related to Vasculitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:00083059.3ITGAM, ITGAX
2membrane raftGO:00451219.2CD79A, SELE, TNF
3external side of plasma membraneGO:00098978.1TNF, VCAM1, ICAM1, ITGAX, ITGAM, CD79A
4extracellular spaceGO:00056158.0LTF, TNF, APOH, MPO, SELE, VCAM1
5plasma membraneGO:00058866.5TNF, FCGR3B, SELE, VCAM1, PRTN3, ICAM1

Biological processes related to Vasculitis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.2ICAM1, VCAM1
2negative regulation of lipid storageGO:001088810.1CRP, TNF
3leukocyte tethering or rollingGO:005090110.1VCAM1, SELE, TNF
4heterophilic cell-cell adhesionGO:000715710.1ICAM1, VCAM1, SELE
5negative regulation of growth of symbiont in hostGO:004413010.0MPO, TNF
6response to lipopolysaccharideGO:00324969.9VCAM1, SELE, MPO
7response to ethanolGO:00454719.8CRP, ICAM1, VCAM1
8agingGO:00075689.8MPO, VCAM1, CRP
9positive regulation of NF-kappaB transcription factor activityGO:00510929.7TNF, ICAM1, LTF
10humoral immune responseGO:00069599.6TNF, SH2D1A, LTF
11response to hypoxiaGO:00016669.6CRP, VCAM1, TNF
12inflammatory responseGO:00069549.5TNF, SELE, IFNA2, CRP
13leukocyte cell-cell adhesionGO:00071599.5ITGAM, ICAM1, VCAM1, SELE
14leukocyte migrationGO:00509009.2SELE, ICAM1, ITGAX, ITGAM
15extracellular matrix organizationGO:00301988.9TNF, VCAM1, ICAM1, ITGAX, ITGAM
16cell adhesionGO:00071558.8ITGAM, ITGAX, ICAM1, VCAM1
17blood coagulationGO:00075968.5SELE, IFNA2, ITGAX, ITGAM

Molecular functions related to Vasculitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.2SELE, ICAM1, CD79A
2heparin bindingGO:00082018.8LTF, ITGAM, MPO, APOH
3protein bindingGO:00055156.8SH2D1A, APOH, SELE, ICAM1, IFNA2, ITGAX

Products for genes affiliated with Vasculitis

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Sources for Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet