MCID: VSC011
MIFTS: 67

Vasculitis malady

Skin diseases, Cardiovascular diseases categories

Summaries for Vasculitis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. it can happen because of an infection, a medicine, or another disease. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges. the bulge is called an aneurysm. if it bursts, it can cause dangerous bleeding inside the body. symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute

MalaCards: Vasculitis, also known as autoimmune vasculitis, is related to retinal vasculitis and retinitis. An important gene associated with Vasculitis is SELE (selectin E), and among its related pathways are Immune response Fc epsilon RI pathway and Integrin Pathway. The drug pentoxifylline and the compounds retinoic acid and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lung and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A vascular disease that is an inflammatory destruction of blood vessels.

NIH Rare Diseases:42 Vasculitis is an inflammation of the vascular system, which includes the veins, arteries, and capillaries. there are many different forms of vasculitis, including temporal arteritis, primary angiitis of the central nervous system, takayasu disease, periarteritis nodosa, kawasaki disease, churg-strauss syndrome, wegener granulomatosis, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, sjogren syndrome, behcet disease and others. signs and symptoms of vasculitis vary depending on the form and on the part of the body affected. in general, the cause of vasculitis is thought to be a faulty immune system response. treatment of vasculitis depends upon the specific diagnosis. most of forms of vasculitis respond well to steroid drugs. some may also require treatment with an immunosuppressive drug, such as cyclophosphamide. last updated: 3/12/2009

Wikipedia:63 Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation.... more...

Aliases & Classifications for Vasculitis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Cardiovascular diseases


Aliases & Descriptions:

vasculitis 8 42 10 44 33 60
autoimmune vasculitis 42 60
angiitis 8 42
vasculitis, autoimmune 42


External Ids:

Disease Ontology8 DOID:865
MeSH34 D014657
NCIt39 C26912
ICD1025 L95.9

Related Diseases for Vasculitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 611)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.4APOH, SAG
2retinitis31.4SAG
3hypersensitivity vasculitis31.0FCGR3B, CD79A, PRTN3, MPO
4cryoglobulinemia30.9CD79A, APOH, IFNA2
5hepatitis30.9IL1RAPL2, IFNA2
6glomerulonephritis30.9VCAM1, CD79A, PRTN3, MPO, CTSG, ICAM1
7lupus erythematosus30.8APOH, IFNA2
8arthritis30.8SELE, SRF, FCGR3B, IL1RAPL2, LTF, PRTN3
9systemic lupus erythematosus30.8SELE, VCAM1, SRF, FCGR3B, IL1RAPL2, CD79A
10hepatitis c30.8SRF, LTF, TNF, IFNA2, IFN1@
11rheumatoid arthritis30.8SELE, VCAM1, SRF, FCGR3B, IL1RAPL2, CD79A
12polyarteritis nodosa30.7LTF, PRTN3, MPO, IFNA2
13retinal disease30.7VCAM1, SRF, LTF, SAG
14purpura30.6CD79A
15wegener's granulomatosis30.6SELE, PRTN3, MPO, CTSG
16churg-strauss syndrome30.6LTF, PRTN3, MPO
17leukemia30.6SRF, FCGR3B, IL1RAPL2, CD79A, SH2D1A, PRTN3
18uveitis30.6TNF, SAG, ICAM1, IFNA2
19neuropathy30.5CD79A
20connective tissue disease30.5SELE, VCAM1, CD79A, PRTN3, MPO, APOH
21rapidly progressive glomerulonephritis30.4PRTN3, MPO, ICAM1
22tuberculosis30.4SRF, IL1RAPL2, CD79A, ITGAM, CTSG, TNF
23polymyalgia rheumatica30.4IL1RAPL2
24meningitis30.4CD79A
25mixed connective tissue disease30.3PRTN3, APOH
26sarcoidosis30.3IL1RAPL2, ITGAM, TNF, ICAM1
27crohn's disease30.3LTF, TNF
28ulcerative colitis30.2SELE, SRF, IL1RAPL2, CD79A, LTF, PRTN3
29acute leukemia30.2PRTN3, MPO, ITGAX, ITGAM
30thyroiditis30.2CD79A
31pneumonia30.2IL1RAPL2, CD79A, MPO, ITGAM, CTSG, TNF
32multiple sclerosis30.2VCAM1, SRF, IL1RAPL2, TNF, SAG, ICAM1
33rheumatoid vasculitis30.2SELE, VCAM1, SRF, LTF, ICAM1
34antiphospholipid syndrome30.2SELE, VCAM1, CD79A, APOH
35myocardial infarction30.2IL1RAPL2, ITGAM
36mononeuritis multiplex30.2PRTN3, MPO
37alpha 1-antitrypsin deficiency30.2PRTN3
38systemic scleroderma30.1SELE, VCAM1, SRF, FCGR3B, PRTN3, CTSG
39eosinophilia30.1VCAM1, SRF, CD79A, PRTN3, MPO, ITGAM
40vascular disease30.1SELE, VCAM1, PRTN3, ITGAM, APOH, ICAM1
41ankylosing spondylitis30.1SRF, IL1RAPL2, CD79A, PRTN3, TNF
42dermatitis30.1SELE, VCAM1, CD79A, ICAM1
43mononeuropathy30.1PRTN3, MPO
44kawasaki disease30.1SELE
45myositis30.1VCAM1, IL1RAPL2, ICAM1
46myeloma30.1VCAM1, IL1RAPL2, CD79A, ITGAM, ICAM1, IFNA2
47hepatitis b30.1CD79A, LTF, SAG, IFNA2, IFN1@
48hypertension30.1SELE, VCAM1, CD79A, ICAM1
49dermatomyositis30.1VCAM1, IL1RAPL2, ICAM1
50influenza30.1CD79A, LTF

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to vasculitis

Clinical Features for Vasculitis

About this section

Drugs & Therapeutics for Vasculitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vasculitis

Drug clinical trials:

Search ClinicalTrials for Vasculitis

Search NIH Clinical Center for Vasculitis

Search CenterWatch for Vasculitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Vasculitis

About this section

Anatomical Context for Vasculitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vasculitis:

32
Endothelial, Lung, T cells, Skin, Heart, B cells, Kidney, Liver, Brain, Thyroid, Monocytes, Testes, Bone, Eye, Breast, Spinal cord, Salivary gland, Myeloid, Bone marrow, Retina, Prostate, Lymph node, Uterus, Pituitary, Small intestine, Colon, Skeletal muscle, Cervix

Animal Models for Vasculitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.4SELE, ICAM1, TNF, CTSG, ITGAM, ITGAX
2MP:000537611.4TNF, APOH, ITGAM, MPO, SH2D1A, LTF
3MP:000539711.1ITGAX, ITGAM, CTSG, TNF, ICAM1, MPO

Publications for Vasculitis

About this section
Sources:
50PubMed
See all sources

Articles related to Vasculitis:

(show top 50)    (show all 2155)
idTitleAuthorsYear
1
Perfusion and spectroscopy magnetic resonance imaging in a case of lymphocytic vasculitis mimicking brain tumor. (24115963)
2013
2
Intravenous cyclophosphamide and plasmapheresis in dialysis-dependent ANCA-associated vasculitis. (23160261)
2013
3
Flare of essential mixed cryoglobulinemic vasculitis with hemorrhagic bullous purpura after rituximab infusion. (23773652)
2013
4
A primer on vasculitis. (23833834)
2013
5
Progressive cicatrizing endotheliitis associated with leucocytoclastic vasculitis and Crohn disease. (23514527)
2013
6
Digital Vasculitis with Eosinophilia Possibly Associated with Etanercept Therapy. (23824408)
2013
7
CNS vasculitis in a patient with MS on daclizumab monotherapy. (23303850)
2013
8
Macular Lymphocytic Arteritis: Three Cases Questioning Its Classification as Primary Lymphocytic Vasculitis. (24334907)
2013
9
Vasculitis in New Zealand. (23180039)
2013
10
Our experience with anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. (24020349)
2012
11
Leukocytoclastic vasculitis associated with influenza A virus infection. (23255867)
2012
12
A case of systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma associated with hypereosinophilia, granulomatous myositis and vasculitis. (22519739)
2012
13
Isolated bladder vasculitis: a rare presentation of Wegener's granulomatosis. (21322469)
2011
14
Central nervous system vasculitis: still more questions than answers. (22379458)
2011
15
Late onset of pANCA renal and pulmonary vasculitis in a girl affected by undifferentiated connective tissue disease. (20133348)
2010
16
Serum HMGB1 levels are increased in active Wegener's granulomatosis and differentiate between active forms of ANCA-associated vasculitis. (20542962)
2010
17
Primary central nervous system vasculitis: Is it a single disease? (21031572)
2010
18
Influence of clinical and demographic variables on mycophenolic acid pharmacokinetics in antineutrophil cytoplasmic antibody-associated vasculitis. (19491317)
2009
19
Mimics of vasculitis: vascular Ehlers-Danlos syndrome masquerading as polyarteritis nodosa. (19671829)
2009
20
Successful reversal of threatening carotid artery occlusion in HIV-associated non-aneurysmal vasculitis. (18334077)
2008
21
Rhinologic symptoms and quality-of-life in patients with Churg-Strauss syndrome vasculitis. (18702907)
2008
22
Microscopic polyangiitis or septic vasculitis? (18578983)
2008
23
Lymphocytic vasculitis associated with icodextrin. (17984440)
2007
24
Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. (17070108)
2007
25
Treatment of total exudative retinal detachment due to central retinal vein occlusion by intravitreal bevacizumab in a patient with p-ANCA vasculitis. (19668494)
2007
26
A case of arthritis and vasculitis associated with the refractory anemia with excess of blasts syndrome resistant to glucocorticoid treatment that responded favorably to TNF-alpha blockade. (16859593)
2006
27
Vasculitis of the aortic arch and cardiac valves as the cause of relapsing fever of unknown origin in an elderly, white man. (16267601)
2006
28
Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis. (15902516)
2006
29
Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated vasculitis. (15758841)
2005
30
Disseminated epitheloid hemangioendothelioma mimicking symptoms of systemic vasculitis. (16160406)
2005
31
Pharmacological therapy of vasculitis: an update. (15063363)
2004
32
Gastrointestinal small vessel vasculitis in a patient with crescentic glomerulonephritis and longstanding idiopathic neutropaenia treated with G-CSF. (12745472)
2003
33
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
34
Role of computed chest tomography (CT scan) in tuberculous retinal vasculitis. (12778352)
2002
35
-463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis. (12027420)
2002
36
Acute leucocytoclastic vasculitis and aquagenic pruritus long preceding polycythemia rubra vera. (11978570)
2002
37
Ehrlichiosis associated vasculitis. (10886489)
2000
38
Myeloperoxidase antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in a very elderly patient with generalized vasculitis at autopsy. (9353970)
1997
39
Vasculitis and bronchiectasis in a patient with antibodies to bactericidal/permeability-increasing protein and alpha1-antitrypsin deficiency. (9404779)
1997
40
A case of eosinophilic pneumonia and vasculitis induced by diflunisal. (9187209)
1997
41
Vasculitis. (8557852)
1995
42
Hypocomplementemic urticarial vasculitis syndrome. Clinical and serologic findings in 18 patients. (7837968)
1995
43
Identification of apparent dual ANCA specificities in a subset of patients with systemic vasculitis and crescentic glomerulonephritis. (8296656)
1993
44
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy. (1556686)
1992
45
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
46
Acute bilateral brachial plexus neuritis associated with hypersensitivity vasculitis. A case report and review of literature. (4032989)
1985
47
Anti-retinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. (6181359)
1982
48
Plasma exchange in rheumatoid vasculitis. (6976658)
1981
49
Immunological investigations in retinal vasculitis. (6964217)
1981
50
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965

Genetic Variations for Vasculitis

About this section

Expression for genes affiliated with Vasculitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vasculitis

Search GEO for disease gene expression data for Vasculitis.

Pathways for genes affiliated with Vasculitis

About this section
Sources:
12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
See all sources

Pathways related to Vasculitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0IFNA2, ICAM1, TNF, SH2D1A, CD79A, FCGR3B
2
Hide members
10.9ICAM1, ITGAM, ITGAX, SRF, VCAM1
310.9IFNA2, TNF, ITGAM, ITGAX, FCGR3B
410.8ICAM1, TNF, VCAM1, SELE
510.8SELE, VCAM1, TNF, ICAM1
610.8VCAM1, MPO, TNF, ICAM1
710.8ICAM1, ITGAM, VCAM1, SELE
810.8MPO, ITGAM, TNF, ICAM1
910.8VCAM1, SRF, TNF, ICAM1
1010.8MPO, SH2D1A, CD79A, VCAM1
1110.7VCAM1, TNF, ICAM1
1210.7VCAM1, TNF, ICAM1
1310.7ICAM1, TNF, MPO
1410.7ICAM1, ITGAM, VCAM1
15
Hide members
10.7VCAM1, ITGAX, ICAM1
1610.7FCGR3B, ITGAM, ICAM1
1710.7SELE, ITGAX, ITGAM
1810.7ITGAM, ITGAX, FCGR3B
1910.6ARR3

Compounds for genes affiliated with Vasculitis

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.0CTSG, TNF, ICAM1, IFNA2, ARR3, ITGAM
2fibrinogen4411.9LTF, CD79A, IL1RAPL2, SRF, VCAM1, SELE
3histamine44 28 2413.9IFNA2, ICAM1, TNF, CTSG, ITGAM, MPO
4vegf4411.9ICAM1, ITGAM, APOH, TNF, IFNA2, MPO
5lactate4411.8VCAM1, SELE, SRF, IL1RAPL2, TNF, ICAM1
6nitric oxide44 11 2413.7SELE, CTSG, ITGAM, ITGAX, MPO, VCAM1
7heparin44 28 11 2414.7CD79A, MPO, ITGAM, CTSG, APOH, IL1RAPL2
8fmlp4411.7ICAM1, CTSG, ITGAM, ITGAX, MPO, PRTN3
9superoxide44 2412.7ITGAX, LTF, IL1RAPL2, FCGR3B, VCAM1, ITGAM
10n-formylmethionyl-leucylphenylalanine4411.6CTSG, TNF, ICAM1, PRTN3, MPO, ITGAX
11lipid4411.6IFNA2, PRTN3, FCGR3B, VCAM1, SELE, ITGAM
12serine4411.6TNF, CTSG, SELE, SRF, FCGR3B, IL1RAPL2
13endotoxin4411.6ICAM1, SELE, VCAM1, SRF, LTF, ITGAM
14creatinine4411.5LTF, CD79A, IL1RAPL2, SRF, SELE, MPO
15leukotriene b444 59 2413.5FCGR3B, TNF, CTSG, ITGAM, ITGAX, LTF
16oxygen44 2412.5PRTN3, MPO, ITGAX, ITGAM, TNF, SAG
17mannose4411.5IL1RAPL2, ITGAX, ITGAM, CD79A, FCGR3B, SRF
18n acetylcysteine4411.5ICAM1, ITGAM, SELE, VCAM1, CD79A, LTF
19polysaccharide4411.5SELE, FCGR3B, VCAM1, CD79A, LTF, ITGAM
20prednisolone44 28 1113.5IFNA2, APOH, ITGAM, MPO, CD79A, IL1RAPL2
21h2o24411.5MPO, IL1RAPL2, FCGR3B, CD79A, LTF, ICAM1
22neopterin4411.4IL1RAPL2, CD79A, LTF, TNF, ICAM1, SRF
23genistein44 28 59 2 11 2416.4VCAM1, SELE, TNF, ITGAM, ICAM1, SRF
24prostacyclin4411.4ICAM1, TNF, APOH, CTSG, LTF, VCAM1
25okt34411.4ICAM1, SELE, CD79A, TNF, SRF, VCAM1
26arachidonic acid44 28 11 2414.4ITGAX, IFNA2, SRF, IL1RAPL2, ITGAM, CTSG
278-isoprostane4411.4ICAM1, VCAM1, SELE, TNF, MPO, APOH
28sulfasalazine44 28 49 1114.4IL1RAPL2, MPO, SELE, TNF, CD79A, ICAM1
29cytochalasin b4411.3LTF, ICAM1, FCGR3B, CTSG, MPO, PRTN3
30cyclosporin a44 28 5913.3LTF, ITGAM, TNF, IL1RAPL2, SAG, CD79A
31infliximab44 49 1113.3IL1RAPL2, PRTN3, APOH, TNF, IFNA2, SELE
32rituximab44 49 1113.3CD79A, TNF, FCGR3B, IFNA2, APOH, PRTN3
33pentoxifylline44 1112.3MPO, ITGAM, VCAM1, IL1RAPL2, LTF
34polyethylene glycol4411.3SELE, IL1RAPL2, MPO, ICAM1, IFNA2, CD79A
35apocynin44 5912.2VCAM1, MPO, TNF, SELE, ICAM1
36polymyxin b4411.2ICAM1, SELE, VCAM1, LTF, TNF
37budesonide44 49 1113.2ICAM1, VCAM1, LTF, MPO, TNF
38cytochalasin d44 5912.1VCAM1, ICAM1, ITGAX, LTF, IL1RAPL2, SELE
39indomethacin44 59 28 1114.1LTF, CTSG, IL1RAPL2
40cycloheximide4411.1ITGAX, ITGAM, CTSG, IL1RAPL2
41etanercept44 49 1113.1FCGR3B, IFNA2, TNF, APOH, IL1RAPL2
42simvastatin44 49 59 28 11 2416.0TNF, ICAM1, SELE, VCAM1, ITGAM, IL1RAPL2
43methacholine44 1112.0CD79A, LTF, CTSG, MPO, ICAM1
44cyclophosphamide44 49 1113.0IFNA2, APOH
45pge24411.0SAG
46dextran sulfate4410.9LTF, MPO, APOH, ICAM1
47alanine4410.9LTF, SELE, CD79A, SRF, VCAM1, PRTN3
48ivig4410.8IL1RAPL2, APOH, SAG, CD79A
49adalimumab44 49 1112.8IL1RAPL2, TNF, CD79A, FCGR3B
50gliclazide44 49 1112.7MPO, SELE, VCAM1, ICAM1

GO Terms for genes affiliated with Vasculitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.3TNF, CTSG, ITGAM, ITGAX, PRTN3, CD79A
2extracellular spaceGO:00561511.0IFNA2, ICAM1, TNF, APOH, CTSG, MPO
3external side of plasma membraneGO:00989711.0VCAM1, ICAM1, TNF, ITGAM, ITGAX, CD79A
4secretory granuleGO:03014110.4CTSG, MPO, LTF

Biological processes related to Vasculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00715911.0SELE, VCAM1, ITGAM, ICAM1
2leukocyte tethering or rollingGO:05090110.8TNF, VCAM1, SELE
3leukocyte migrationGO:05090010.8ICAM1, ITGAM, ITGAX, SELE
4negative regulation of growth of symbiont in hostGO:04413010.8MPO, CTSG, TNF
5membrane to membrane dockingGO:02261410.6VCAM1, ICAM1
6heterophilic cell-cell adhesionGO:00715710.6SELE, VCAM1, ICAM1
7humoral immune responseGO:00695910.4TNF, SH2D1A, LTF

Molecular functions related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1opsin bindingGO:00204610.6ARR3, SAG
2heparin bindingGO:00820110.6LTF, MPO, ITGAM, CTSG, APOH

Products for genes affiliated with Vasculitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vasculitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet