MCID: VSC011
MIFTS: 67

Vasculitis malady

Skin diseases, Cardiovascular diseases categories

Summaries for Vasculitis

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. it can happen because of an infection, a medicine, or another disease. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges. the bulge is called an aneurysm. if it bursts, it can cause dangerous bleeding inside the body. symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute

MalaCards: Vasculitis, also known as autoimmune vasculitis, is related to retinal vasculitis and retinitis. An important gene associated with Vasculitis is SELE (selectin E), and among its related pathways are Immune response Fc epsilon RI pathway and Integrin Pathway. The drug pentoxifylline and the compounds retinoic acid and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lung and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A vascular disease that is an inflammatory destruction of blood vessels.

NIH Rare Diseases:42 Vasculitis is an inflammation of the vascular system, which includes the veins, arteries, and capillaries. there are many different forms of vasculitis, including temporal arteritis, primary angiitis of the central nervous system, takayasu disease, periarteritis nodosa, kawasaki disease, churg-strauss syndrome, wegener granulomatosis, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, sjogren syndrome, behcet disease and others. signs and symptoms of vasculitis vary depending on the form and on the part of the body affected. in general, the cause of vasculitis is thought to be a faulty immune system response. treatment of vasculitis depends upon the specific diagnosis. most of forms of vasculitis respond well to steroid drugs. some may also require treatment with an immunosuppressive drug, such as cyclophosphamide. last updated: 3/12/2009

Wikipedia:63 Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation.... more...

Aliases & Classifications for Vasculitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Cardiovascular diseases


Aliases & Descriptions:

vasculitis 8 42 10 44 33 60
autoimmune vasculitis 42 60
angiitis 8 42
vasculitis, autoimmune 42


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Disease Ontology8 DOID:865
MeSH34 D014657
NCIt39 C26912
ICD1025 L95.9

Related Diseases for Vasculitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 611)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.4APOH, SAG
2retinitis31.4SAG
3hypersensitivity vasculitis31.0FCGR3B, CD79A, PRTN3, MPO
4cryoglobulinemia30.9CD79A, APOH, IFNA2
5hepatitis30.9IL1RAPL2, IFNA2
6glomerulonephritis30.9VCAM1, CD79A, PRTN3, MPO, CTSG, ICAM1
7lupus erythematosus30.8APOH, IFNA2
8arthritis30.8SELE, SRF, FCGR3B, IL1RAPL2, LTF, PRTN3
9systemic lupus erythematosus30.8SELE, VCAM1, SRF, FCGR3B, IL1RAPL2, CD79A
10hepatitis c30.8SRF, LTF, TNF, IFNA2, IFN1@
11rheumatoid arthritis30.8SELE, VCAM1, SRF, FCGR3B, IL1RAPL2, CD79A
12polyarteritis nodosa30.7LTF, PRTN3, MPO, IFNA2
13retinal disease30.7VCAM1, SRF, LTF, SAG
14purpura30.6CD79A
15wegener's granulomatosis30.6SELE, PRTN3, MPO, CTSG
16churg-strauss syndrome30.6LTF, PRTN3, MPO
17leukemia30.6SRF, FCGR3B, IL1RAPL2, CD79A, SH2D1A, PRTN3
18uveitis30.6TNF, SAG, ICAM1, IFNA2
19neuropathy30.5CD79A
20connective tissue disease30.5SELE, VCAM1, CD79A, PRTN3, MPO, APOH
21rapidly progressive glomerulonephritis30.4PRTN3, MPO, ICAM1
22tuberculosis30.4SRF, IL1RAPL2, CD79A, ITGAM, CTSG, TNF
23polymyalgia rheumatica30.4IL1RAPL2
24meningitis30.4CD79A
25mixed connective tissue disease30.3PRTN3, APOH
26sarcoidosis30.3IL1RAPL2, ITGAM, TNF, ICAM1
27crohn's disease30.3LTF, TNF
28ulcerative colitis30.2SELE, SRF, IL1RAPL2, CD79A, LTF, PRTN3
29acute leukemia30.2PRTN3, MPO, ITGAX, ITGAM
30thyroiditis30.2CD79A
31pneumonia30.2IL1RAPL2, CD79A, MPO, ITGAM, CTSG, TNF
32multiple sclerosis30.2VCAM1, SRF, IL1RAPL2, TNF, SAG, ICAM1
33rheumatoid vasculitis30.2SELE, VCAM1, SRF, LTF, ICAM1
34antiphospholipid syndrome30.2SELE, VCAM1, CD79A, APOH
35myocardial infarction30.2IL1RAPL2, ITGAM
36mononeuritis multiplex30.2PRTN3, MPO
37alpha 1-antitrypsin deficiency30.2PRTN3
38systemic scleroderma30.1SELE, VCAM1, SRF, FCGR3B, PRTN3, CTSG
39eosinophilia30.1VCAM1, SRF, CD79A, PRTN3, MPO, ITGAM
40vascular disease30.1SELE, VCAM1, PRTN3, ITGAM, APOH, ICAM1
41ankylosing spondylitis30.1SRF, IL1RAPL2, CD79A, PRTN3, TNF
42dermatitis30.1SELE, VCAM1, CD79A, ICAM1
43mononeuropathy30.1PRTN3, MPO
44kawasaki disease30.1SELE
45myositis30.1VCAM1, IL1RAPL2, ICAM1
46myeloma30.1VCAM1, IL1RAPL2, CD79A, ITGAM, ICAM1, IFNA2
47hepatitis b30.1CD79A, LTF, SAG, IFNA2, IFN1@
48hypertension30.1SELE, VCAM1, CD79A, ICAM1
49dermatomyositis30.1VCAM1, IL1RAPL2, ICAM1
50influenza30.1CD79A, LTF

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to vasculitis

Clinical Features for Vasculitis

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Drugs & Therapeutics for Vasculitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Vasculitis

Drug clinical trials:

Search ClinicalTrials for Vasculitis

Search NIH Clinical Center for Vasculitis

Search CenterWatch for Vasculitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Vasculitis

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Anatomical Context for Vasculitis

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32MalaCards
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MalaCards organs/tissues related to Vasculitis:

32
Endothelial, Lung, T cells, Skin, Heart, B cells, Kidney, Liver, Brain, Thyroid, Monocytes, Testes, Bone, Eye, Spinal cord, Breast, Myeloid, Salivary gland, Bone marrow, Prostate, Retina, Uterus, Lymph node, Skeletal muscle, Small intestine, Colon, Cervix, Pituitary

Animal Models for Vasculitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.4SELE, ICAM1, TNF, CTSG, ITGAM, ITGAX
2MP:000537611.4TNF, APOH, ITGAM, MPO, SH2D1A, LTF
3MP:000539711.1ITGAX, ITGAM, CTSG, TNF, ICAM1, MPO

Publications for Vasculitis

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Sources:
50PubMed
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Articles related to Vasculitis:

(show top 50)    (show all 2155)
idTitleAuthorsYear
1
Tocilizumab in glucocorticoid-naA^ve large-vessel vasculitis. (23306184)
2013
2
Recurrence of abdominal large-vessel vasculitis and development of severe Sweet syndrome after a single cycle of 5-azacytidine in a patient with myelodysplastic syndrome. (24341928)
2013
3
Transient monocular vision loss due to churg-strauss syndrome vasculitis. (23307226)
2013
4
Clinical features and etiology of retinal vasculitis in Northern Thailand. (24178403)
2013
5
Retinal vasculitis in two pediatric patients with systemic lupus erythematosus: a case report. (23734963)
2013
6
Therapy for hepatitis C virus-related cryoglobulinemic vasculitis. (24024840)
2013
7
Panniculitis with vasculitis. (23900160)
2013
8
L21. Kidneys in ANCA-associated vasculitis: what to learn from biopsies? (23481364)
2013
9
Marfan syndrome with antineutrophil cytoplasmic antibody-associated systemic vasculitis presenting as severe anaemia and haematuria after the Bentall procedure. (23435525)
2013
10
S2. Rituximab for ANCA-associated vasculitis: the UK experience. (23490639)
2013
11
Anti-neutrophil cytoplasmic antibody-associated systemic vasculitis: nature or nurture? (24020350)
2012
12
Pulmonary disease in small-vessel vasculitis. (23203641)
2012
13
Defining disease activity and damage in patients with small-vessel vasculitis. (23203638)
2012
14
Possible central nervous system vasculitis as an early presentation of Crohn's disease. A challenge in diagnosis and management. (22964818)
2012
15
Crescentic glomerulonephritis and leucocytoclastic vasculitis associated with acute EBV infection. (21793991)
2011
16
Cutaneous vasculitis induced by TNF inhibitors: a report of three cases. (19812889)
2010
17
A case of polymyositis and vasculitis induced by ovulation induction therapy with gonadotropin-releasing hormone. (20437250)
2010
18
Differential diagnosis of retinal vasculitis. (20404987)
2009
19
CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. (19815671)
2009
20
Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis. (19690440)
2009
21
Small-vessel vasculitis surrounding an uninflamed temporal artery: a new diagnostic criterion for polymyalgia rheumatica? (18668584)
2008
22
Retinal vasculitis. (16321886)
2005
23
Rifabutin-associated panuveitis with retinal vasculitis in pulmonary tuberculosis. (16321897)
2005
24
Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. (15801034)
2005
25
Factors influencing patient survival and renal function outcome in pulmonary-renal syndrome associated with ANCA (+) vasculitis: a single-center experience. (15772921)
2005
26
Decrease over time in the incidence of systemic rheumatoid vasculitis: Comment on the article by Turesson et al. (15880813)
2005
27
Small fiber neuropathy due to isolated vasculitis of the peripheral nervous system. (15055280)
2004
28
Polyarteritis nodosa reports to the vaccine adverse event reporting system (VAERS): implications for assessment of suspected vaccine-provoked vasculitis. (15517631)
2004
29
Pyothorax caused by Nocardia otitidiscaviarum in a patient with rheumatoid vasculitis. (15335193)
2004
30
Successful treatment of severe rheumatoid vasculitis by infliximab. (12759302)
2003
31
Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis. (12945480)
2003
32
Myocardial infarction caused by rheumatoid vasculitis: histological evidence of the involvement of T lymphocytes. (14634788)
2003
33
Monocyte activation and relationship to anti-proteinase 3 in acute vasculitis. (12937226)
2003
34
Effector T cells and macrophages in urine as a hallmark of systemic vasculitis accompanied by crescentic glomerulonephritis. (12584287)
2003
35
Acute posterior multifocal placoid pigment epitheliopathy with retinal vasculitis and papillitis. (12194084)
2002
36
Successful treatment of leucocytoclastic vasculitis and pancytopenia secondary to systemic lupus erythematosus with intravenous immunoglobulin. (12100207)
2002
37
Wiskott-Aldrich syndrome, vasculitis and critical aortic dilatation. (11808912)
2001
38
Takayasu arteritis and cutaneous necrotizing vasculitis. (10773704)
2000
39
Systemic vasculitis associated with seronegative spondylarthropathy (Reiter's syndrome). (9456014)
1997
40
Gallbladder vasculitis and mixed cryoglobulinemia. (7835849)
1994
41
Von Willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases. (8187441)
1994
42
Is vasculitis in subacute bacterial endocarditis associated with ANCA? (1672428)
1991
43
Vasculitis and Cogan's syndrome. (2189159)
1990
44
Vasculitis and renal disease in nail-patella syndrome: case report and literature review. (3662646)
1987
45
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986
46
Cutaneous leukocytoclastic vasculitis with hyperglobulinemia and splenomegaly. A variant of hyperglobulinemic purpura of WaldenstrAPm. (6206803)
1984
47
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982
48
Hypersensitivity vasculitis group (HVG). A case-oriented review of a continuing clinical spectrum. (6212166)
1982
49
Circulating immune complexes in retinal vasculitis. (891035)
1977
50
Placoid pigment epitheliopathy with retinal vasculitis and papillitis. (4651979)
1972

Genetic Variations for Vasculitis

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Expression for genes affiliated with Vasculitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vasculitis

Search GEO for disease gene expression data for Vasculitis.

Pathways for genes affiliated with Vasculitis

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12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Pathways related to Vasculitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0IFNA2, ICAM1, TNF, SH2D1A, CD79A, FCGR3B
2
Hide members
10.9ICAM1, ITGAM, ITGAX, SRF, VCAM1
310.9IFNA2, TNF, ITGAM, ITGAX, FCGR3B
410.8ICAM1, TNF, VCAM1, SELE
510.8SELE, VCAM1, TNF, ICAM1
610.8VCAM1, MPO, TNF, ICAM1
710.8ICAM1, ITGAM, VCAM1, SELE
810.8MPO, ITGAM, TNF, ICAM1
910.8VCAM1, SRF, TNF, ICAM1
1010.8MPO, SH2D1A, CD79A, VCAM1
1110.7VCAM1, TNF, ICAM1
1210.7VCAM1, TNF, ICAM1
1310.7ICAM1, TNF, MPO
1410.7ICAM1, ITGAM, VCAM1
15
Hide members
10.7VCAM1, ITGAX, ICAM1
1610.7FCGR3B, ITGAM, ICAM1
1710.7SELE, ITGAX, ITGAM
1810.7ITGAM, ITGAX, FCGR3B
1910.6ARR3

Compounds for genes affiliated with Vasculitis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.0CTSG, TNF, ICAM1, IFNA2, ARR3, ITGAM
2fibrinogen4411.9LTF, CD79A, IL1RAPL2, SRF, VCAM1, SELE
3histamine44 28 2413.9IFNA2, ICAM1, TNF, CTSG, ITGAM, MPO
4vegf4411.9ICAM1, ITGAM, APOH, TNF, IFNA2, MPO
5lactate4411.8VCAM1, SELE, SRF, IL1RAPL2, TNF, ICAM1
6nitric oxide44 11 2413.7SELE, CTSG, ITGAM, ITGAX, MPO, VCAM1
7heparin44 28 11 2414.7CD79A, MPO, ITGAM, CTSG, APOH, IL1RAPL2
8fmlp4411.7ICAM1, CTSG, ITGAM, ITGAX, MPO, PRTN3
9superoxide44 2412.7ITGAX, LTF, IL1RAPL2, FCGR3B, VCAM1, ITGAM
10n-formylmethionyl-leucylphenylalanine4411.6CTSG, TNF, ICAM1, PRTN3, MPO, ITGAX
11lipid4411.6IFNA2, PRTN3, FCGR3B, VCAM1, SELE, ITGAM
12serine4411.6TNF, CTSG, SELE, SRF, FCGR3B, IL1RAPL2
13endotoxin4411.6ICAM1, SELE, VCAM1, SRF, LTF, ITGAM
14creatinine4411.5LTF, CD79A, IL1RAPL2, SRF, SELE, MPO
15leukotriene b444 59 2413.5FCGR3B, TNF, CTSG, ITGAM, ITGAX, LTF
16oxygen44 2412.5PRTN3, MPO, ITGAX, ITGAM, TNF, SAG
17mannose4411.5IL1RAPL2, ITGAX, ITGAM, CD79A, FCGR3B, SRF
18n acetylcysteine4411.5ICAM1, ITGAM, SELE, VCAM1, CD79A, LTF
19polysaccharide4411.5SELE, FCGR3B, VCAM1, CD79A, LTF, ITGAM
20prednisolone44 28 1113.5IFNA2, APOH, ITGAM, MPO, CD79A, IL1RAPL2
21h2o24411.5MPO, IL1RAPL2, FCGR3B, CD79A, LTF, ICAM1
22neopterin4411.4IL1RAPL2, CD79A, LTF, TNF, ICAM1, SRF
23genistein44 28 59 2 11 2416.4VCAM1, SELE, TNF, ITGAM, ICAM1, SRF
24prostacyclin4411.4ICAM1, TNF, APOH, CTSG, LTF, VCAM1
25okt34411.4ICAM1, SELE, CD79A, TNF, SRF, VCAM1
26arachidonic acid44 28 11 2414.4ITGAX, IFNA2, SRF, IL1RAPL2, ITGAM, CTSG
278-isoprostane4411.4ICAM1, VCAM1, SELE, TNF, MPO, APOH
28sulfasalazine44 28 49 1114.4IL1RAPL2, MPO, SELE, TNF, CD79A, ICAM1
29cytochalasin b4411.3LTF, ICAM1, FCGR3B, CTSG, MPO, PRTN3
30cyclosporin a44 28 5913.3LTF, ITGAM, TNF, IL1RAPL2, SAG, CD79A
31infliximab44 49 1113.3IL1RAPL2, PRTN3, APOH, TNF, IFNA2, SELE
32rituximab44 49 1113.3CD79A, TNF, FCGR3B, IFNA2, APOH, PRTN3
33pentoxifylline44 1112.3MPO, ITGAM, VCAM1, IL1RAPL2, LTF
34polyethylene glycol4411.3SELE, IL1RAPL2, MPO, ICAM1, IFNA2, CD79A
35apocynin44 5912.2VCAM1, MPO, TNF, SELE, ICAM1
36polymyxin b4411.2ICAM1, SELE, VCAM1, LTF, TNF
37budesonide44 49 1113.2ICAM1, VCAM1, LTF, MPO, TNF
38cytochalasin d44 5912.1VCAM1, ICAM1, ITGAX, LTF, IL1RAPL2, SELE
39indomethacin44 59 28 1114.1LTF, CTSG, IL1RAPL2
40cycloheximide4411.1ITGAX, ITGAM, CTSG, IL1RAPL2
41etanercept44 49 1113.1FCGR3B, IFNA2, TNF, APOH, IL1RAPL2
42simvastatin44 49 59 28 11 2416.0TNF, ICAM1, SELE, VCAM1, ITGAM, IL1RAPL2
43methacholine44 1112.0CD79A, LTF, CTSG, MPO, ICAM1
44cyclophosphamide44 49 1113.0IFNA2, APOH
45pge24411.0SAG
46dextran sulfate4410.9LTF, MPO, APOH, ICAM1
47alanine4410.9LTF, SELE, CD79A, SRF, VCAM1, PRTN3
48ivig4410.8IL1RAPL2, APOH, SAG, CD79A
49adalimumab44 49 1112.8IL1RAPL2, TNF, CD79A, FCGR3B
50gliclazide44 49 1112.7MPO, SELE, VCAM1, ICAM1

GO Terms for genes affiliated with Vasculitis

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16Gene Ontology
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Cellular components related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.3TNF, CTSG, ITGAM, ITGAX, PRTN3, CD79A
2extracellular spaceGO:00561511.0IFNA2, ICAM1, TNF, APOH, CTSG, MPO
3external side of plasma membraneGO:00989711.0VCAM1, ICAM1, TNF, ITGAM, ITGAX, CD79A
4secretory granuleGO:03014110.4CTSG, MPO, LTF

Biological processes related to Vasculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00715911.0SELE, VCAM1, ITGAM, ICAM1
2leukocyte tethering or rollingGO:05090110.8TNF, VCAM1, SELE
3leukocyte migrationGO:05090010.8ICAM1, ITGAM, ITGAX, SELE
4negative regulation of growth of symbiont in hostGO:04413010.8MPO, CTSG, TNF
5membrane to membrane dockingGO:02261410.6VCAM1, ICAM1
6heterophilic cell-cell adhesionGO:00715710.6SELE, VCAM1, ICAM1
7humoral immune responseGO:00695910.4TNF, SH2D1A, LTF

Molecular functions related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1opsin bindingGO:00204610.6ARR3, SAG
2heparin bindingGO:00820110.6LTF, MPO, ITGAM, CTSG, APOH

Products for genes affiliated with Vasculitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet