Vasculitis malady

MedlinePlus: Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges and may burst and cause dangerous bleeding inside the body symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute²³

MalaCards: Vasculitis, also known as angiitis, is related to retinal vasculitis and lymphocytic vasculitis. An important gene associated with Vasculitis is VCAM1 (vascular cell adhesion molecule 1), and among its related pathways are Cell adhesion molecules (CAMs) and Staphylococcus aureus infection. The drug pentoxifylline and the compounds n-formylmethionyl-leucylphenylalanine and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: A vascular disease that is an inflammatory destruction of blood vessels.⁶

Wikipedia: Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation....⁴⁴ more...

Aliases & Descriptions:

vasculitis 6 17 8 32 23 43 angiitis 6

Diseases related to vasculitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 999)

id	Related Disease	Score	Top Affiliating Genes
1	retinal vasculitis	35.2	SAG, ARR3, APOH, CCL4, IFN1@, IFNA2
2	lymphocytic vasculitis	34.0	SH2D1A, SH2D4B, SELE, VCAM1, ITGAM, ITGAX
3	rheumatoid vasculitis	34.0	REN, SELE, VCAM1, IL1RAPL2, ICAM1, HLA-DRB1
4	systemic lupus erythematosus	33.0	PDCD1, VWF, SELE, SERPINB1, VCAM1, BLZF1
5	rheumatoid arthritis	32.2	CD226, CD40, MIF, IL10, IL1B, IL1RN
6	arthritis	32.0	SELL, SERPINA1, IL17A, IL1B, IL6, IL8
7	hepatitis	31.4	SELP, SERPINA1, FAS, IFNA1, IFNA2, IFNB1
8	connective tissue disease	31.1	BMP6, CD36, APOH, ENO1, HSPG2, HSPD1
9	microscopic polyangiitis	30.9	SELE, MPO, FCGR2A, FCGR2B, FCGR3A, FCGR3B
10	hepatitis c	30.9	SERPINA1, CD40LG, MMP1, IL10, IL18, IL2
11	behcet's disease	30.5	SELE, SELL, SAG, MEFV, IL18, IL2RA
12	churg-strauss syndrome	30.4	MPO, IL10, IL2, IL2RA, IL4, IL5
13	polyarteritis nodosa	30.0	REN, MPO, CD40LG, FGF2, MEFV, IL6
14	cryoglobulinemia	29.8	VWF, SELE, VCAM1, BMP6, MT1H, CD79A
15	wegener's granulomatosis	29.7	VWF, SELE, SERPINA1, SERPINA3, SERPINB1, VCAM1
16	sneddon syndrome	28.7	SERPINC1, CD79A, APOH, F5, F2, PF4
17	reactive arthritis	28.6	BPI, CD79A, IFNB1, HSPD1, HP, CRP
18	ankylosing spondylitis	28.6	SERPINA1, CD79A, CD40LG, IL17A, IL1R1, IL1RAPL2
19	henoch-schoenlein purpura	28.3	VCAM1, MPO, CD79A, MEFV, ICAM1
20	lupus nephritis	28.1	PDCD1, VWF, SELE, VEGFA, VCAM1, BMP6
21	immune-complex glomerulonephritis	27.8	SELP, VCAM1, CFI, MPO, CD40LG, ITGAL
22	panniculitis	27.6	SERPINA1, IL2RA, APOH, FAS, IGHE, IFNB1
23	thromboangiitis obliterans	27.6	SELE, SERPINB1, VCAM1, ICAM1, PLAT, NOS3
24	hodgkin's lymphoma	27.6	SH2D1A, SELP, BLZF1, CD80, CD40, ITGA4
25	venous thrombosis	27.4	LRP1, VWF, SELP, SELPLG, SERPINC1, ITGAM
26	hemangioendothelioma	27.4	VWF, VEGFA, KDR, FGF2, IL2, CCL2
27	autoimmune thyroiditis	27.4	CD80, CD40, ITGAL, ITGB2, IL2RA, IL4
28	respiratory failure	27.2	CMA1, SCGB1A1, IGES, IGHE, CAT, PPARA
29	lymphoproliferative syndrome	27.0	SH2D1A, CD40LG, IL10, IL2, IL2RA, FAS
30	nephritis	27.0	PDCD1, REN, VWF, SELE, SELP, SERPINA1
31	diffuse panbronchiolitis	27.0	MPO, CD79A, IL1B, IL1RAPL2, IL1RN, IL5
32	panbronchiolitis	27.0	MPO, CD79A, IL1B, IL1RAPL2, IL1RN, IL5
33	eales disease	27.0	VEGFA, SAG, IL4, IL6, F5, TNF
34	bronchiectasis	26.8	SERPINA1, SERPINA3, SERPINB1, BPI, MPO, CD79A
35	psoriatic arthritis	26.7	IL10, IL1B, IL1RAPL2, IL1RN, IL6, TNF
36	myelodysplastic syndrome	26.6	SELL, BOK, MPO, CD177, GYPA, IL3
37	central retinal vein occlusion	26.6	VWF, SERPINC1, VEGFA, IL6, APOH, F5
38	non-hodgkin lymphoma	26.5	SH2D1A, SELL, CD86, CD14, CD80, CD40
39	retinal detachment	26.3	VEGFA, FN1, FGF2, IL6, CCL2, HMGB1
40	ulcerative colitis	26.2	SELE, SELL, SELP, SERPINA1, BPI, LCN2
41	alpha 1-antitrypsin deficiency	26.1	SERPINC1, SERPINA1, SERPINA3, SERPINB1, VEGFA, BPI
42	funisitis	25.8	IL10, IL1B, IL6, IL8, CRP
43	angioedema	25.7	SERPINC1, SERPINA1, SERPING1, SERPINB1, IL2, IL5
44	leukopenia	25.6	SELL, SERPINC1, BPI, MPO, CD79A, ITGAL
45	sepsis	25.3	SELE, SELL, SELP, SERPINC1, SERPING1, BPI
46	cytomegalovirus infection	25.2	PDCD1, VWF, SELE, SELL, SELP, SERPINA1
47	retinal vein occlusion	24.9	VWF, SERPINC1, VEGFA, CD79A, CD40LG, IL10
48	crohn's disease	24.8	BPI, LCN2, MPO, CD80, MIF, IL10
49	hepatitis a	24.6	SERPINC1, CD79A, CD40LG, GYPA, MEFV, IL10
50	familial mediterranean fever	24.5	SELL, SELP, SERPINC1, VEGFA, SAA4, CD14

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pentoxifylline

MalaCards organs/tissues related to vasculitis:

²²

MGI Mouse Phenotypes related to vasculitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.9	SELL, SELP, SERPINB1, SCGB1A1, CD14, FCGR2B
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	SELL, CD40LG, IL2, GNAQ, GNRH1, CTLA4
3	renal/urinary system phenotype	MP:0005367	9.4	PDCD1, REN, SELP, SELPLG, SCGB1A1, CFI
4	integument phenotype	MP:0010771	9.0	SELP, SELPLG, LAMP2, ITGB2, FGA, MEFV
5	reproductive system phenotype	MP:0005389	8.8	REN, VEGFA, LAMP2, CGA, MMP9, FN1
6	other phenotype	MP:0005395	8.5	SH2B3, KDR, CD40LG, FN1, IL2, APP
7	digestive/alimentary phenotype	MP:0005381	8.4	VWF, VEGFA, CD36, MMP7, MMP9, INS
8	nervous system phenotype	MP:0003631	8.1	LRP1, PDCD1, REN, VWF, SELP, SERPINC1
9	growth/size phenotype	MP:0005378	8.0	LRP1, REN, SELE, SELP, VCAM1, BMP6
10	liver/biliary system phenotype	MP:0005370	7.8	SERPINC1, VEGFA, LECT2, CD36, INS, FGA
11	skeleton phenotype	MP:0005390	7.6	LRP1, VEGFA, BMP6, KDR, LAMP2, CFP
12	mortality/aging	MP:0010768	7.5	LRP1, PDCD1, REN, VWF, SELE, SELP
13	adipose tissue phenotype	MP:0005375	7.4	LRP1, CD36, CD14, INS, IL18, IL1R1
14	muscle phenotype	MP:0005369	7.0	LRP1, PDCD1, REN, VEGFA, KDR, LAMP2
15	tumorigenesis	MP:0002006	6.5	SELL, SCGB1A1, LECT2, CD226, ITGAL, MMP2
16	behavior/neurological phenotype	MP:0005386	6.5	LRP1, REN, SELE, SELP, KDR, S100A1
17	vision/eye phenotype	MP:0005391	6.5	PDCD1, SELE, SELP, SERPINC1, VEGFA, KDR
18	homeostasis/metabolism phenotype	MP:0005376	4.3	LRP1, REN, VWF, SELE, SELL, SELP
19	cardiovascular system phenotype	MP:0005385	4.1	LRP1, PDCD1, REN, VWF, SELE, SELL
20	normal phenotype	MP:0002873	INF	LRP1, REN, SELE, SERPING1, VEGFA, KDR
21	cellular phenotype	MP:0005384	INF	SH2B3, SH2D1A, PDCD1, VWF, SELE, SELL
22	immune system phenotype	MP:0005387	INF	LRP1, SH2D1A, REN, VWF, SELL, SELP
23	hematopoietic system phenotype	MP:0005397	INF	SH2B3, SH2D1A, PDCD1, SERPINB1, LECT2, LCN2

Articles related to vasculitis:

(show top 50)    (show all 464)

id	Title	Authors	Year	Affiliating Genes
1	SERPING1 polymorphisms in polypoidal choroidal vascul opathy. (20161815)	Li M.... Luo G.	2010	SERPING1
2	Local tissue distribution and cellular fate of vascul ar endothelial growth factor (VEGF) following intramuscular injection. (19624285)	Daugherty A.L.... Mrsny R.J.	2010	VEGFA
3	Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update. (19815703)	GA^mez-Puerta J.A.... Bosch X.	2009	MPO, PRTN3
4	Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement. (19164323)	KA1mpers P.... Haubitz M.	2009	ANGPT2
5	CT60 and +49 polymorphisms of CTLA 4 are associated w ith ANCA-positive small vessel vasculitis. (19815671)	Kamesh L.... Harper L.	2009	CTLA4
6	Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. (19264905)	Little M.A.... Pusey C.D.	2009	MPO
7	Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. (18550853)	Sansonno D.... Dammacco F.	2008	CXCL13
8	ANCA-associated renal vasculitis following anti-tumor necrosis factor alpha therapy. (18295046)	Simms R.... Rodger R.S.	2008	TNF
9	Hepatitis C-associated leukocytoclastic vasculitis wi th anticardiolipin antibodies causing penile necrosis and deep venous thrombosi s in the absence of cryoglobulinemia. (18438797)	Daniels A.H.... Harrison R.A.	2008	APOH
10	Comparison of the clinical characteristics of vasculitis occurring during anti-tumor necrosis factor treatment or not in rheumatoid arthritis patients. A systematic review of 2707 patients, 18 vasculitis. (18799049)	Guignard S.... Dougados M.	2008	TNF
11	Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients. (18562305)	Kobayashi S.... Nojima H.	2008	INPP4A, RSL24D1
12	Current state of biologicals in the management of systemic vasculitis. (17911441)	Lamprecht P.... Gross W.L.	2007	TNF
13	Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative stress-derived molecules in hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. (17393409)	Saadoun D.... Cacoub P.	2007	MMP7, HSP90AA1, HSPA4
14	A CX3CR1 genotype associated with retinal vasculitis in patients in the United Kingdom. (16799040)	Wallace G.R.... Stanford M.R.	2006	CX3CR1
15	Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies. (17108314)	Schreiber A.... Jennette J.C.	2006	MPO
16	Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitis. (16361277)	Raza K.... Bacon P.A.	2006	TNF
17	Endothelial dysfunction and vasculitis: a close relationship (16750094)	LA^pez RodrA-guez M.... Barbado HernA!ndez F.J.	2006	TNF, CRP
18	TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations. (17699331)	Huugen D.... Heeringa P.	2006	TNF, MPO, PRTN3
19	Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement. (16107582)	HolmAcn C.... Sumitran-Holgersson S.	2005	CCL3
20	B cell epitope specificity in ANCA-associated vasculitis: does it matter? (15320893)	van der Geld Y.M.... Kallenberg C.G.	2004	PRTN3
21	Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. (15529352)	Gorman J.D.... Criswell L.A.	2004	HLA-DRB1
22	P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition. (15123773)	Yanaba K.... Sato S.	2004	SELL, SELPLG
23	Antibodies to proteinase-3 and myeloperoxidase in systemic vasculitis (15230127)	Baranov A.A.... AbaA-tova N.E.	2004	MPO, PRTN3
24	Proinflammatory genotype of interleukin-1 and interleukin-1 receptor antagonist is associated with ESRD in proteinase 3-ANCA vasculitis patients. (12722027)	Borgmann S.... Fricke H.	2003	IL1B, IL1RN, IL1RAPL2
25	Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)	Pacora P.... Romero R.	2002	IL6
26	Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (12415593)	Amoli M.M.... Gonzalez-Gay M.A.	2002	IL8, CXCL5
27	Antioxidants inhibit mercuric chloride-induced early vasculitis. (11867563)	Wu Z.... Oliveira D.B.	2002	IGHE
28	Soluble cytokine receptors in renal vasculitis and lupus nephritis. (11782670)	Tesar V.... Zabka J.	2002	IL18R1
29	Antineutrophil cytoplasmic antibodies (ANCA) and systemic vasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation. (10805352)	Schultz D.R.... Diego J.M.	2000	MPO, PRTN3
30	No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis. (10729297)	McKibbin M.... Morrell A.J.	2000	TNF, IL1R1
31	Birmingham vasculitis activity score, disease extent index and complement factor C3c reflect disease activity best in hepatitis C virus-associated cryoglobulinemic vasculitis. (10895368)	Lamprecht P.... Gross W.L.	2000	CRP, IFNA2
32	Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. (10194473)	Rittner H.L.... Weyand C.M.	1999	AKR1B1
33	Influence of plasma exchange on serum levels of cytokines and adhesion molecules in ANCA-positive renal vasculitis. (9572400)	Tesar V.... Zima T.	1998	ICAM1, VCAM1, IL1RN
34	Cutaneous allergic vasculitis: clinicopathological characterization and identification of apoptosis. (9778109)	Shi Y.... Koizumi F.	1998	BOK
35	Induction of endothelial cell adhesion molecules by serum and immunoglobulins G from a patient with vasculitis and monoclonal gammapathy: potential relevance to vasculitis. (9759630)	Dupuy E.... Tobelem G.	1998	ICAM1, SELE, VCAM1
36	Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) by autoantibodies in autoimmune vasculitis. (9158091)	Johnson P.A.... Maxwell A.P.	1997	ICAM1
37	Usefulness of procalcitonin for differentiation betwe en activity of systemic autoimmune disease (systemic lupus erythematosus/system ic antineutrophil cytoplasmic antibody-associated vasculitis) and invasive bact erial infection. (9214425)	Eberhard O.K.... Brunkhorst R.	1997	IL6, CRP
38	Antibody reactivity against thyroid peroxidase and myeloperoxidase in autoimmune thyroiditis and systemic vasculitis. (9246211)	Haapala A.M.... Soppi E.	1997	MPO, TPO
39	ANCA-associated forms of vasculitis (9065053)	Helmchen U.... Prall F.	1996	MPO, PRTN3
40	Respiratory failure in ANCA-associated vasculitis. (8697833)	er Maaten J.C.... Hoorntje S.J.	1996	PRTN3
41	Antineutrophil cytoplasmic autoantibodies, autoantigens, and systemic vasculitis. (7748541)	Gross W.L.... Helmchen U.	1995	PRTN3
42	Antigen specificity in hydralazine associated ANCA positive systemic vasculitis. (8542262)	Short A.K.... Lockwood C.M.	1995	MPO, LTF
43	Gout masquerading as rheumatoid vasculitis. (8182655)	Sharma A.... Lisse J.R.	1994	SRF
44	Fc gamma receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis. (8318044)	Hundt M.... Schmidt R.E.	1993	FCGR3B
45	Chronic lymphoid leukemia, leiomyoblastoma, thrombos ing vasculitis and anticardiolipin antibodies: apropos of a case (8378638)	Fautrel B.... Delfraissy J.F.	1993	APOH
46	Circulating intercellular adhesion molecules-1 and autoantibodies including anti-endothelial cell, anti-cardiolipin, and anti-neutrophil cytoplasma antibodies in patients with vasculitis. (8258240)	Wang C.R.... Chen C.Y.	1993	ICAM1
47	State of hemostasis in hemorrhagic vasculitis in chi ldren (1513626)	Iakunina L.N.... Tsymbal I.N.	1992	F2
48	Livedo vasculitis: vasculitis or thrombotic vasculopa thy? (1424259)	McCalmont C.S.... Rothberger H.	1992	FGA
49	Endothelium myeloperoxidase-antimyeloperoxidase interaction in vasculitis. (1336132)	Vargunam M.... Thompson R.A.	1992	MPO
50	Enhanced expression of the tumour necrosis factor/cachectin gene in peripheral blood mononuclear cells from patients with systemic vasculitis. (1696867)	Deguchi Y.... Kishimoto S.	1990	TNF

Genes related to vasculitis according to GeneCards:

(show top 50)    (show all 207)

id	Symbol	Description	Score	GeneCards Section Context
1	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
2	ICAM1	intercellular adhesion molecule 1	11.0	Publications
3	SELE	selectin E	11.0	Publications
4	TNF	tumor necrosis factor	11.0	Publications
5	MPO	myeloperoxidase	11.0	Publications
6	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
7	SAG	S-antigen; retina and pineal gland (arrestin)	11.0	Publications
8	LTF	lactotransferrin	11.0	Publications
9	PRTN3	proteinase 3	11.0	Publications
10	SH2D1A	SH2 domain containing 1A	11.0	Publications
11	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0	Publications
12	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
13	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
14	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
15	IFNA2	interferon, alpha 2	11.0	Publications
16	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
17	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
18	IFN1@	interferon, type 1, cluster	11.0	Publications
19	ARR3	arrestin 3, retinal (X-arrestin)	11.0	Publications
20	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	11.0	Publications
21	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
22	PTX3	pentraxin 3, long	11.0	Publications
23	C1S	complement component 1, s subcomponent	11.0	Publications
24	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
25	BPI	bactericidal/permeability-increasing protein	11.0	Publications
26	MEFV	Mediterranean fever	11.0	Publications
27	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0	Publications
28	CTSG	cathepsin G	11.0	Publications
29	SH2D4B	SH2 domain containing 4B	11.0	Publications
30	ENO1	enolase 1, (alpha)	11.0	Publications
31	LCN2	lipocalin 2	11.0	Publications
32	SELL	selectin L	11.0	Publications
33	ELANE	elastase, neutrophil expressed	11.0	Publications
34	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
35	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
36	TPMT	thiopurine S-methyltransferase	11.0	Publications
37	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
38	BLZF1	basic leucine zipper nuclear factor 1	11.0	Publications
39	CFI	complement factor I	11.0	Publications
40	FGA	fibrinogen alpha chain	11.0	Publications
41	RXRB	retinoid X receptor, beta	11.0	Publications
42	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0	Publications
43	IL17A	interleukin 17A	11.0	Publications
44	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
45	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
46	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
47	THBD	thrombomodulin	11.0	Publications
48	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
49	CD80	CD80 molecule	11.0	Publications
50	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications

Pathways related to vasculitis according to GeneDecks:

(show top 50)    (show all 122)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	11.2	SELL, SELP, SELPLG, CD86, CD80, CD226
2	Staphylococcus aureus infection20	11.1	SELP, SELPLG, CFI, ITGAL, ITGAM, ITGB2
3	Immune System38	10.6	PDCD1, VCAM1, CD79A, CD226, CD40, MEFV
4	RAR-Gamma-RXR-Alpha Degradation36	10.5	CD80, IL2, IL3, CCL4, CCL3, TNFSF13B
5	Akt Signaling36	10.2	VEGFC, CD80, ITGAL, ITGAM, ITGAX, ITGB2
6	Glioma Invasiveness36	10.2	VEGFC, BMP6, ITGA4, ITGAL, ITGAM, ITGAX
7	THC Differentiation Pathway36	10.0	CD86, IL10, IL12RB1, IL18, IL18R1, IL2
8	Tuberculosis20	10.0	LAMP2, CD14, ITGAM, ITGAX, ITGB2, FCGR2A
9	Regulation of eIF4 and p70S6K36	10.0	VEGFC, CD80, ITGA4, ITGAL, ITGAM, ITGAX
10	Transendothelial Migration of Leukocytes36	10.0	VCAM1, ITGA4, ITGAL, ITGAM, ITGAX, ITGB2
11	NFAT Signaling and Lymphocyte Interactions36	10.0	BMP6, CD80, FCER1A, IL2, IL3, IL4
12	PPAR Pathway36	9.9	VEGFC, ITGA4, ITGAL, ITGAM, ITGAX, ITGB2
13	IL-6 Pathway36	9.8	BMP6, CD80, IL10, IL18, IL3, IL4
14	Complement and coagulation cascades20	9.7	VWF, SERPINC1, SERPINA1, SERPING1, CFI, FGA
15	Toll-like receptor signaling pathway20	9.6	CD86, CD14, CD80, CD40, IL1B, IL6
16	Intestinal immune network for IgA production20	9.6	CD86, CD40LG, CD80, CD40, ITGA4, IL10
17	Molecular Mechanisms of Cancer36	9.6	VEGFC, BMP6, KDR, CD80, ITGA4, ITGAL
18	Rheumatoid arthritis20	9.6	VEGFA, CD86, CD80, ITGAL, ITGB2, MMP1
19	Allograft rejection20	9.5	CD86, CD40LG, CD80, CD40, IL10, IL2
20	Amoebiasis20	9.5	SERPINB1, CD14, ITGAM, ITGB2, FN1, IL1B
21	Malaria20	9.5	LRP1, SELE, SELP, VCAM1, CD36, CD40LG
22	Autoimmune thyroid disease20	9.5	CGA, CD86, CD40LG, CD80, CD40, IL10
23	Leishmaniasis20	9.4	ITGA4, ITGAM, ITGB2, FCGR2A, FCGR3A, FCGR3B
24	JNK Pathway36	9.4	BMP6, KDR, CD80, FGF2, IL18R1, IL1R1
25	Immune response MIF-mediated glucocorticoid regulation10	9.4	VCAM1, MMP1, MIF, IL2, IL6, IL8
26	Immune response_MIF-mediated glucocorticoid regulation41	9.3	VCAM1, MMP1, MIF, IL2, IL6, IL8
27	MAPK Signaling36	9.0	VEGFC, BMP6, KDR, ITGA4, ITGAL, ITGAM
28	Endothelin-1 Signaling Pathway36	9.0	BMP6, CD80, IL10, IL18, IL1B, IL2
29	Hematopoietic cell lineage20	8.9	CD36, CD14, ITGA4, ITGAM, GYPA, IL1B
30	ERK Signaling36	8.9	VEGFC, BMP6, CD80, ITGA4, ITGAL, ITGAM
31	NF-KappaB Family Pathway36	8.9	VEGFC, BMP6, KDR, FGF2, IL1B, IL1R1
32	PEDF Induced Signaling36	8.9	BMP6, CD80, IL10, IL18, IL1B, IL2
33	PGC1Alpha Pathway36	8.9	BMP6, CD80, IL18, IL1B, IL1R1, IL2
34	STAT3 Pathway36	8.9	BMP6, CD80, IL10, IL12RB1, IL18, IL18R1
35	Cytokine Network36	8.8	IL10, IL18, IL1B, IL2, IL3, IL4
36	Rho Family GTPases36	8.7	VEGFC, BMP6, KDR, CD80, ITGA4, ITGAL
37	Tec Kinases Signaling36	8.5	VEGFC, BMP6, CD80, ITGA4, ITGAL, ITGAM
38	all-trans-Retinoic Acid Signaling in Brain36	8.4	BMP6, CD80, IL10, IL18, IL1B, IL2
39	Glucocorticoid Receptor Signaling36	8.4	BMP6, CD80, IL10, IL18, IL18R1, IL1B
40	MIF Mediated Glucocorticoid Regulation36	8.4	BMP6, CD14, CD80, MIF, IL10, IL18
41	MIF Regulation of Innate Immune Cells36	8.4	BMP6, CD14, CD80, MIF, IL10, IL18
42	Antioxidant Action of Vitamin-C36	8.3	VEGFC, BMP6, KDR, CD80, FGF2, IL10
43	PAK Pathway36	8.2	VEGFC, BMP6, KDR, CD80, FGF2, IL10
44	p38 Signaling36	8.2	VEGFC, BMP6, KDR, CD80, FGF2, IL10
45	MAPK Family Pathway36	8.2	VEGFC, BMP6, KDR, CD80, FGF2, IL10
46	NF-KappaB (p50-p65) Pathway36	8.2	VEGFC, BMP6, KDR, FGF2, IL1B, IL1R1
47	SOCS Pathway36	8.2	VEGFC, BMP6, CD80, INS, FGF2, IL10
48	TGF-Beta Pathway36	8.1	VEGFC, BMP6, KDR, CD80, FGF2, IL10
49	Cytokine-cytokine receptor interaction20	7.7	VEGFA, VEGFC, KDR, CD40LG, CD40, IL10
50	JAK-STAT Pathway36	7.4	VEGFC, BMP6, KDR, CD80, FGF2, IL10

Compounds related to vasculitis according to GeneDecks:

(show top 50)    (show all 502)

id	Compound	Score	Top Affiliating Genes
1	n-formylmethionyl-leucylphenylalanine32	11.3	SELL, SELP, SELPLG, LCN2, MPO, ITGAL
2	endotoxin32	11.0	SELL, BPI, SCGB1A1, SAA4, AZU1, CD86
3	lysine32	10.9	SERPINA1, SAG, AZU1, GYPA, FCGR2A, CCL3
4	ivig32	10.8	VWF, SAG, FCGR2B, FCGR3A, IL18R1, IL1RAPL2
5	hocl32	10.8	SERPINA1, MPO, MMP7, CAT, CYBA, CTSG
6	txb232	10.7	REN, VWF, SELP, FGA, IL1RAPL2, IL1RN
7	apocynin32	10.7	SELE, VCAM1, MPO, ICAM1, CAT, DYT10
8	nacl32	10.6	REN, SERPINA3, BLZF1, S100A1, CFI, MMP7
9	phosphatidylserine32 9 9	12.6	VWF, SELE, SELPLG, CD79A, CD14, MIF
10	fmlp32	10.5	SELL, SELP, SELPLG, SERPINA3, VCAM1, BPI
11	natalizumab32 9 9	12.5	ITGA4, FCGR2A, FCGR2B, FCGR3A, FCGR3B, IL10
12	heparan sulfate32 18	11.4	LRP1, SERPINC1, BMP6, KDR, AZU1, ITGB2
13	oxygen32 18	11.3	SELPLG, SERPINA1, SERPINA3, BOK, BLZF1, SCGB1A1
14	estradiol32 9 18 9	13.3	REN, SERPINA3, VEGFC, BOK, CGA, CFI
15	cuprophan32	10.3	SELL, SELP, VCAM1, CD14, ITGAL, ITGAM
16	tirofiban32 9 9	12.3	VWF, SELP, SERPINC1, CD40LG, ANXA5, F2
17	citrate32	10.2	SELP, BLZF1, CD79A, FGF2, HSP90AA1, CAT
18	atp32	10.1	BLZF1, SAG, CD14, ITGAM, ITGB2, FGA
19	malondialdehyde32	10.0	MPO, FGA, IL2RA, APOH, F5, HSPA4
20	phorbol32	10.0	SELL, CD40, ITGAL, ITGAM, ITGAX, ITGB2
21	pge132	9.9	VWF, SELL, CD40, MMP1, FGA, IL18
22	formaldehyde32 18	10.8	VWF, SELE, SELL, SELP, BLZF1, MPO
23	aprotinin32 9 9	11.7	LRP1, VWF, SELP, SERPINC1, MMP2, MMP9
24	gp 13032	9.7	BMP6, SCGB1A1, IL12RB1, IL18R1, IL1R1, IL2RA
25	polymyxin b32	9.5	SELE, VCAM1, BPI, CD14, ITGB2, IL10
26	polysulfone32	9.4	VWF, SELL, SELP, VCAM1, BPI, CD14
27	ang ii32	9.4	REN, VEGFA, SAG, CD36, ANPEP, CCL2
28	fenofibrate32 9 9	11.3	SELE, SELP, VCAM1, CD40LG, CD40, MMP9
29	erythromycin32 9 9	11.2	VCAM1, MPO, CD40LG, ITGB2, MMP2, MMP9
30	chloroquine32 34 9 9	12.1	SERPINC1, BMP6, CD79A, ITGAL, ITGAM, IL10
31	diphenyleneiodonium32	9.0	VEGFA, VCAM1, MPO, IL1B, IL1R1, IL8
32	histamine32 18	9.9	VWF, SELE, SELL, SELP, SELPLG, VCAM1
33	cysteine32	8.9	LRP1, SELP, SELPLG, SERPINA1, SERPINA3, BPI
34	matrigel32	8.8	LRP1, VWF, SELE, VEGFA, VEGFC, VCAM1
35	n acetylcysteine32	8.8	VWF, SELE, SELP, SERPINC1, VCAM1, KDR
36	calcitriol32 42 9 18 9	12.7	REN, BMP6, CFI, CD36, CD14, ITGAL
37	pioglitazone32 9 9	10.6	VEGFA, VCAM1, CD40, MMP1, MMP2, MMP7
38	perindopril32 34 9 9	11.5	REN, VWF, VEGFA, ALB, CRP, PLAT
39	doxorubicin32 34 9 9	11.5	SELE, BMP6, KDR, CGA, CD40LG, CD40
40	alpha tocopherol32	8.2	VCAM1, SAA4, CD36, ITGAL, ITGAM, MMP1
41	5fluorouracil32	8.1	SELE, VEGFA, KDR, MPO, CD36, MMP2
42	prednisolone32 9 9	10.0	VWF, SELL, VCAM1, BMP6, LCN2, MPO
43	mycophenolate mofetil32 9 9	10.0	SELE, SELP, CD79A, CD36, CD40LG, CD40
44	cholesterol32 9 18 9	10.8	LRP1, REN, VWF, SELE, SELP, SELPLG
45	ciglitazone32	7.6	MMP2, MMP9, IL1B, IL6, IL8, CCL2
46	candesartan32 9 9	9.6	REN, SELP, VEGFA, MMP1, MMP2, CCL2
47	tacrolimus32 34 9 9	10.2	REN, BMP6, CD79A, CD36, CD86, CD40
48	cisplatin32 34 9 9	10.0	VEGFA, BMP6, BLZF1, KDR, CGA, CFI
49	herbimycin a32 42	7.8	SELE, SELL, VCAM1, BMP6, CD36, CD14
50	dexamethasone32 42 34 9 9	8.5	LRP1, REN, VWF, SELL, SELP, SELPLG

Cellular components related to vasculitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	10.2	ICAM1, ANPEP, ANXA5, FAS, IL4, IL17A
2	membrane raft	GO:045121	10.0	EDNRA, TNFRSF1B, TNFRSF1A, TNF, TRAF2, FAS
3	integral to plasma membrane	GO:005887	9.9	TPO, HLA-DRB1, HLA-C, ERBB3, CASR, F2R
4	cell surface	GO:009986	9.6	TNF, TNFRSF1A, CTSG, PLAT, ABCB1, ELANE
5	secretory granule	GO:030141	9.3	CTSG, PLAT, LTF, ELANE, CYBA, HSPD1
6	platelet alpha granule lumen	GO:031093	9.1	KNG1, TGFB1, TIMP1, PF4, PPBP, ALB
7	plasma membrane	GO:005886	8.5	GNAQ, FCGR3A, FCGR2B, FCGR2A, FCER1A, FGA
8	extracellular space	GO:005615	5.6	CXCL5, CXCL13, CX3CL1, TGFB1, THBD, AGT
9	extracellular region	GO:005576	4.9	PF4, F5, IFNB1, IFNA2, CCL3, CCL2

Biological processes related to vasculitis according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte cell-cell adhesion	GO:007159	11.2	ICAM1, ITGB2, ITGAL, ITGA4, CD40LG, VCAM1
2	leukocyte migration	GO:050900	11.0	MMP1, FN1, ANGPT2, ICAM1, F2, ELANE
3	regulation of immune response	GO:050776	10.9	FCGR3A, IL4, ICAM1, ICAM2, ICAM3, HLA-C
4	innate immune response	GO:045087	10.9	TXN, HMGB1, IFNB1, IFNA2, TRAF2, CYBA
5	defense response to bacterium	GO:042742	10.8	LTF, TLR4, PRG2, CXCL13, NOS2, PPBP
6	B cell proliferation	GO:042100	10.8	HSPD1, IFNB1, IL10, CD40, CD40LG, CD79A
7	cell adhesion	GO:007155	10.7	IL2, APP, CCL4, CCL2, F5, ICAM1
8	negative regulation of growth of symbiont in host	GO:044130	10.6	IL10, MBL2, TNF, CTSG, ELANE, CD36
9	defense response to Gram-negative bacterium	GO:050829	10.6	TLR4, NOS2, IL6R, IL6, MMP7, AZU1
10	cellular response to lipopolysaccharide	GO:071222	10.5	CX3CR1, TLR4, NOS2, TNFRSF1B, ICAM1, CCL2
11	positive regulation of MHC class II biosynthetic process	GO:045348	10.2	TLR4, IL4, IL10, CD40LG, AZU1
12	positive regulation of chemokine production	GO:032722	10.2	TLR4, HIF1A, TNF, IL6R, IL6, IL18
13	extracellular matrix disassembly	GO:022617	10.2	TIMP1, ELANE, CTSG, MMP9, MMP7, MMP2
14	positive regulation of tumor necrosis factor production	GO:032760	10.2	CD14, IL18, CCL3, TNFRSF1A, PF4, TLR4
15	positive regulation of inflammatory response	GO:050729	10.2	CX3CL1, TLR4, AGT, EDNRA, TNFRSF1A, CCL3
16	cellular response to interleukin-1	GO:071347	10.1	HIF1A, ICAM1, CCL3, CCL2, IL8, IL17A
17	extracellular matrix organization	GO:030198	10.1	NFKB2, ELANE, ELN, AGT, GFAP, TIMP1
18	cytokine-mediated signaling pathway	GO:019221	10.1	HLA-C, HLA-DRB1, TNFRSF1A, PTPN2, PF4, CX3CL1
19	neutrophil chemotaxis	GO:030593	10.1	CXCR2, CX3CL1, SPP1, CCL3, CCL2, IL8
20	acute-phase response	GO:006953	10.0	CRP, F2, MBL2, IL6R, IL6, IL1RN
21	positive regulation of interferon-gamma production	GO:032729	10.0	TLR4, TNF, HSPD1, IL2, IL1B, IL18
22	lipopolysaccharide-mediated signaling pathway	GO:031663	9.8	IL1B, CCL2, CCL3, TNF, NOS3, TLR4
23	immune response	GO:006955	9.8	TNFSF13B, HLA-DRB1, HLA-C, IGHE, CCL4, MBP
24	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.6	AGT, PPARD, ERBB3, CAT, F2R, F2
25	response to lipopolysaccharide	GO:032496	9.6	CTSG, EDNRA, ELANE, TLR4, THBD, EPO
26	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	IL5, IL6, IL6R, AGT, TLR4, IL3
27	positive regulation of angiogenesis	GO:045766	9.5	CX3CR1, CX3CL1, HIF1A, NOS3, TNFRSF1A, ANGPT2
28	cellular response to mechanical stimulus	GO:071260	9.5	TLR5, TLR4, AGT, EDNRA, TNFRSF1A, FAS
29	positive regulation of interleukin-6 production	GO:032755	9.4	TLR4, CD36, TNF, HSPD1, IL6R, IL6
30	cellular response to organic cyclic compound	GO:071407	9.4	IL18, IL1B, CCL2, CCL3, TNF, PPARG
31	angiogenesis	GO:001525	9.4	ANPEP, CCL2, HSPG2, NOS3, HIF1A, ANGPT2
32	positive regulation of B cell proliferation	GO:030890	9.4	CD40LG, CD40, MIF, IL2, IL4, IL5
33	cell-cell signaling	GO:007267	9.3	IL3, CCL4, CCL3, IFNA2, GNRH1, TXN
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TLR4, PTX3, PTGS2, TNF, HSP90AA1, ICAM1
35	embryo implantation	GO:007566	9.2	EPO, SCGB1A1, MMP9, IL1B, PTGS2, SPP1
36	anti-apoptosis	GO:006916	9.2	GNRH1, TNF, NOS3, COMP, PRDX2, SOD1
37	platelet degranulation	GO:002576	9.2	KNG1, LAMP2, VEGFC, VEGFA, SERPING1, SERPINA1
38	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	TGFB1, TLR4, AGT, NFKB2, TNF, TRAF2
39	inflammatory response	GO:006954	9.1	BMP6, SERPINA3, SELP, SELE, KNG1, CXCR2
40	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	SRF, TNF, TRAF2, IL6, IL5, IL4
41	response to glucocorticoid stimulus	GO:051384	8.9	PLAT, PTGS2, TNF, HMGB1, CCL2, FAS
42	aging	GO:007568	8.9	EPO, TGFB1, TIMP1, AGT, EDNRA, NOS3
43	response to hypoxia	GO:001666	8.8	CX3CL1, PRKAA1, TGFB1, TLR4, ANGPT2, FAS
44	positive regulation of apoptotic process	GO:043065	8.8	CTLA4, NOS3, AGT, TLR4, SOD1, KNG1
45	signal transduction	GO:007165	8.8	TRAF2, TXN, ERBB3, HSP90AA1, GNRH1, CCL2
46	blood coagulation	GO:007596	8.7	PPBP, GNAQ, ALB, F2R, F2, F5
47	platelet activation	GO:030168	8.6	CX3CL1, IL6, FGA, FN1, CD40, CD40LG
48	negative regulation of apoptotic process	GO:043066	8.4	PF4, EDNRA, TIMP1, PRKAA1, CX3CL1, CX3CR1
49	positive regulation of cell proliferation	GO:008284	8.2	TNFSF13B, PPARD, EDNRA, TIMP1, TGFB1, PRKAA1
50	response to drug	GO:042493	8.0	TNF, PTGS2, CYP19A1, PPARG, NOS3, ABCB1

Molecular functions related to vasculitis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	10.8	SERPINC1, VEGFA, AZU1, MPO, FN1, FGF2
2	chemokine activity	GO:008009	10.5	CXCL5, CXCL13, CX3CL1, PF4, PPBP, CCL3
3	chemoattractant activity	GO:042056	10.2	CCL3, FGF2, MIF, VEGFC, VEGFA, HMGB1
4	receptor binding	GO:005102	10.1	F2, F2R, CAT, TNFSF13B, NOS2, CX3CL1
5	protease binding	GO:002020	10.1	CST3, ELANE, TNFRSF1A, TNF, MBP, IL1R1
6	eukaryotic cell surface binding	GO:043499	10.0	EPO, TGFB1, ANXA5, MBL2, APOH, FGA
7	serine-type endopeptidase activity	GO:004252	9.8	PRTN3, ELANE, C1S, LTF, PLAT, CTSG
8	cytokine activity	GO:005125	8.7	VEGFA, BMP6, CD40LG, MIF, FGF2, IL10
9	growth factor activity	GO:008083	7.8	IL5, IL6, F2, PPBP, AGT, TGFB1
10	protein binding	GO:005515	5.2	PTPN2, TIMP1, THBD, TGFB1, PRKAA1, PRTN3