MCID: VSC011
MIFTS: 66

Vasculitis malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Vasculitis

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MedlinePlus:33 Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. it can happen because of an infection, a medicine, or another disease. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges. the bulge is called an aneurysm. if it bursts, it can cause dangerous bleeding inside the body. symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute

MalaCards based summary: Vasculitis, also known as autoimmune vasculitis, is related to retinal vasculitis and lupus erythematosus. An important gene associated with Vasculitis is SELE (selectin E), and among its related pathways are Cellular roles of Anthrax toxin and Thromboxane A2 receptor signaling. The drug pentoxifylline and the compounds apocynin and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, endothelial and lung, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A vascular disease that is characterized by inflammation of the blood vessels.

NIH Rare Diseases:42 Vasculitis is an inflammation of the vascular system, which includes the veins, arteries, and capillaries. there are many different forms of vasculitis, including temporal arteritis, primary angiitis of the central nervous system, takayasu disease, periarteritis nodosa, kawasaki disease, churg-strauss syndrome, wegener granulomatosis, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, sjogren syndrome, behcet disease and others. signs and symptoms of vasculitis vary depending on the form and on the part of the body affected. in general, the cause of vasculitis is thought to be a faulty immune system response. treatment of vasculitis depends upon the specific diagnosis. most of forms of vasculitis respond well to steroid drugs. some may also require treatment with an immunosuppressive drug, such as cyclophosphamide. last updated: 3/12/2009

Wikipedia:65 Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation.... more...

Aliases & Classifications for Vasculitis

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Vasculitis, Aliases & Descriptions:

Name: Vasculitis 8 42 10 44 33 62
Autoimmune Vasculitis 42 62
 
Angiitis 8 42
Vasculitis, Autoimmune 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:865
NCIt39 C26912
MeSH34 D014657

Related Diseases for Vasculitis

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Diseases related to Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 669)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis32.2SAG, APOH
2lupus erythematosus31.6APOH, IFNA2
3rheumatoid vasculitis31.6LTF, VCAM1, SELE, ICAM1
4systemic lupus erythematosus31.5FCGR3B, CRP
5purpura31.4CD79A
6hepatitis c31.3TNF, IFNA2, LTF
7cryoglobulinemia31.3CD79A, APOH, IFNA2
8wegener's granulomatosis31.1PRTN3, MPO, SELE
9churg-strauss syndrome31.1MPO, LTF, PRTN3
10retinal artery occlusion31.0APOH
11hypersensitivity vasculitis31.0MPO, FCGR3B, CD79A, PRTN3
12rapidly progressive glomerulonephritis31.0ICAM1, MPO, PRTN3
13uveitis31.0TNF, SAG, ICAM1, IFNA2
14polyarteritis nodosa31.0LTF, IFNA2, PRTN3, MPO
15glomerulonephritis30.9VCAM1, MPO, CD79A, PRTN3, ICAM1
16scleritis30.9PRTN3
17mononeuritis multiplex30.9PRTN3, MPO
18mixed connective tissue disease30.9APOH, PRTN3
19colitis30.8TNF, MPO, LTF
20mononeuropathy30.8MPO, PRTN3
21endophthalmitis30.8SAG
22panuveitis30.8IFNA2
23crohn's disease30.8CRP, TNF, LTF
24peripheral vascular disease30.8SELE, VCAM1
25familial mediterranean fever30.7CRP, TNF
26polymyositis30.7VCAM1, SELE, ICAM1
27kawasaki disease30.7CRP, SELE
28endocarditis30.7PRTN3
29chickenpox30.7CD79A
30sarcoidosis30.7TNF, ICAM1, ITGAM
31degos disease30.7APOH
32rheumatic disease30.7TNF, CRP, APOH
33multiple sclerosis30.6ICAM1, VCAM1, TNF, SAG
34syphilis30.5CD79A, APOH
35thyroiditis30.5CD79A
36membranoproliferative glomerulonephritis30.5IFNA2, CD79A
37lupus nephritis30.5APOH, VCAM1, ICAM1, CD79A
38ulcerative colitis30.5PRTN3, LTF, CRP, TNF
39ankylosing spondylitis30.5CRP, CD79A, TNF
40vascular disease30.5TNF, APOH, ITGAM
41pustulosis palmaris et plantaris30.4SELE
42dermatitis30.4CD79A, ICAM1, SELE, VCAM1
43graves' disease30.4MPO, ICAM1, VCAM1, SELE
44rheumatic fever30.4CRP
45psoriatic arthritis30.4TNF, CRP, SELE
46leukocyte adhesion deficiency30.3ITGAM
47pancreatitis30.3ICAM1, MPO, CRP, LTF
48chorioamnionitis30.3LTF, CRP, TNF
49psoriasis30.3SELE, TNF, ICAM1, VCAM1, LTF
50immunoglobulin a vasculitis30.3VCAM1, CD79A, ICAM1, MPO

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to vasculitis

Symptoms for Vasculitis

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Drugs & Therapeutics for Vasculitis

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Drug clinical trials:

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Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Vasculitis

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Anatomical Context for Vasculitis

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MalaCards organs/tissues related to Vasculitis:

32
Neutrophil, Endothelial, Lung, T cells, Heart, Skin, B cells, Kidney, Liver, Brain, Thyroid, Monocytes, Eye, Testes, Bone, Breast, Spinal cord, Bone marrow, Salivary gland, Myeloid, Retina, Prostate, Lymph node, Skeletal muscle, Small intestine, Colon, Uterus, Cervix, Pituitary

Animal Models for Vasculitis or affiliated genes

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MGI Mouse Phenotypes related to Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.7SELE, MPO, APOH, SH2D1A, VCAM1, ICAM1
2MP:00053975.6SELE, MPO, SH2D1A, TNF, VCAM1, PRTN3
3MP:00053875.5LTF, TNF, SH2D1A, MPO, SELE, VCAM1

Publications for Vasculitis

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Articles related to Vasculitis:

(show top 50)    (show all 2265)
idTitleAuthorsYear
1
Cutaneous vasculitis overlap with acute generalised exanthematous pustulosis (AGEP). (25404248)
2014
2
The case for cost-effectively treating cryoglobulinemic vasculitis with interferon-free anti-hepatitis C virus therapy. (25380535)
2014
3
Failure of Recombinant Activated Factor VII in Treatment of Diffuse Alveolar Hemorrhage due to Cryoglobulinemic Vasculitis. (25114814)
2014
4
Perfusion and spectroscopy magnetic resonance imaging in a case of lymphocytic vasculitis mimicking brain tumor. (24115963)
2013
5
The clinical characteristics of retinal vasculitis in HLA-B27-positive patients. (24102118)
2013
6
Headache and vasculitis. (23338772)
2013
7
Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis. (22962314)
2013
8
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
9
Cocaine induced vasculitis: have we found a culprit? (23346447)
2012
10
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
11
Cutaneous vasculitis induced by TNF inhibitors: a report of three cases. (19812889)
2010
12
Hypersensitivity vasculitis associated with leuprolide (Lupron). (20470239)
2010
13
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (19714622)
2009
14
Necrotizing lymphocytic vasculitis limited to the peripheral nerves: report of six cases and review. (20204175)
2009
15
Rickettsia sibirica subsp. mongolitimonae infection and retinal vasculitis. (18394301)
2008
16
Is carotidynia syndrome a subset of vasculitis? (18785305)
2008
17
ANCA-associated vasculitis: diagnostic and therapeutic strategy. (17460438)
2007
18
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
19
The role of biologic therapies in the management of systemic vasculitis. (16697969)
2006
20
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
21
SIR 2004 film panel case: Primary hyperoxaluria type I mimicking arterial vasculitis--a lethal disease. (15361574)
2004
22
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. (15160961)
2004
23
Degos' disease mimicking vasculitis. (15188339)
2004
24
Diagnostic, prognostic and pathogenic value of the direct immunofluorescence test in cutaneous leukocytoclastic vasculitis. (14693016)
2004
25
Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. (14740443)
2003
26
Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis. (12685871)
2002
27
Cerebrospinal fluid neurofilament and glial fibrillary acidic protein in patients with cerebral vasculitis. (11891800)
2002
28
Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. (12380603)
2002
29
Tissue targeting and disease patterns in systemic vasculitis. (11469821)
2001
30
Limited cutaneous systemic sclerosis associated with MPO-ANCA positive renal small vessel vasculitis of the microscopic polyangiitis type. (10977809)
2000
31
Leukocytoclastic vasculitis in a child with epidermolysis bullosa simplex. (10770671)
1999
32
New concepts in treatment protocols for severe systemic vasculitis. (9894629)
1999
33
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
34
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
35
Myeloperoxidase antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in a very elderly patient with generalized vasculitis at autopsy. (9353970)
1997
36
Alpha-1-antitrypsin phenotyping in ANCA-associated diseases: one of several arguments for protease/antiprotease imbalance in systemic vasculitis. (9493789)
1997
37
Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (8697616)
1996
38
ANCA-associated forms of vasculitis]. (9065053)
1996
39
Mycobacterium chelonae infection mimicking cutaneous vasculitis: case report. (8922834)
1996
40
Reduced red blood cell deformability in patients with rheumatoid vasculitis. Improvement after in vitro treatment with dipyridamole. (7848316)
1995
41
ANCA and predicting relapse in systemic vasculitis. (7704563)
1995
42
Pro- and anti-inflammatory cytokines in primary systemic vasculitis. (8296631)
1993
43
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
44
Elimination diet in the treatment of selected patients with hypersensitivity vasculitis. (1505105)
1992
45
Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. (1791222)
1991
46
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986
47
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
48
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
49
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982
50
Cutaneous leukocytoclastic vasculitis in the rose spot of paratyphoid fever. (6807856)
1982

Variations for Vasculitis

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Expression for genes affiliated with Vasculitis

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Expression patterns in normal tissues for genes affiliated with Vasculitis

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Pathways for genes affiliated with Vasculitis

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Pathways related to Vasculitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0VCAM1, TNF
29.8ICAM1, VCAM1, SELE
3
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.8SELE, VCAM1, ICAM1
49.8ICAM1, VCAM1, TNF
59.8TNF, VCAM1, ICAM1
69.5ICAM1, VCAM1, SELE, TNF
79.5TNF, SELE, VCAM1, ICAM1
89.5TNF, SELE, VCAM1, ICAM1
99.5ICAM1, VCAM1, MPO, TNF
109.4VCAM1, ICAM1, ITGAM
119.4VCAM1, ICAM1, ITGAM
12
Show member pathways
thioredoxin pathway37
9.4TNF, MPO, ICAM1, CRP
13
Show member pathways
9.2IFNA2, ICAM1, SH2D1A, TNF
149.2ITGAM, ICAM1, FCGR3B
15
Show member pathways
9.2TNF, FCGR3B, ITGAM
169.2ITGAM, FCGR3B, MPO
179.2SELE, VCAM1, ICAM1, ITGAM
18
Show member pathways
9.1ITGAM, ITGAX, SELE
199.1TNF, MPO, ICAM1, ITGAM
209.0CD79A, VCAM1, MPO, SH2D1A
21
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.0ITGAX, ITGAM, CRP
228.9FCGR3B, ITGAX, ITGAM
23
Show member pathways
8.9ITGAM, ITGAX, ICAM1, VCAM1
248.9ITGAM, ITGAX, ICAM1, VCAM1
25
Show member pathways
8.9ITGAM, ITGAX, ICAM1, VCAM1
26
Show member pathways
Immune response CD16 signaling in NK cells60
8.8TNF, SH2D1A, FCGR3B, ICAM1, IFNA2
27
Show member pathways
8.8SELE, IFNA2, ITGAX, ITGAM
288.3TNF, FCGR3B, IFNA2, ITGAX, ITGAM

Compounds for genes affiliated with Vasculitis

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Compounds related to Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1apocynin44 6110.6ICAM1, TNF, MPO, VCAM1, SELE
2polymyxin b449.5SELE, VCAM1, TNF, LTF, ICAM1
3gliclazide44 50 1111.5VCAM1, ICAM1, SELE, MPO
4hydroxychloroquine44 1110.5IFNA2, CRP, APOH, TNF
5budesonide44 50 1111.5LTF, ICAM1, MPO, TNF, VCAM1
6fenofibrate44 50 1111.4CRP, SELE, VCAM1, ICAM1, TNF
7dextran sulfate449.3APOH, MPO, SELE, ICAM1, LTF
8etanercept44 50 1111.2CRP, APOH, TNF, FCGR3B, IFNA2
9okt3449.1TNF, SELE, CD79A, VCAM1, ICAM1, CRP
108-isoprostane449.1ICAM1, TNF, APOH, MPO, SELE, VCAM1
11sulfasalazine28 44 50 1112.0CD79A, ICAM1, MPO, TNF, CRP, SELE
12methacholine44 50 1111.0MPO, ICAM1, CRP, LTF, CD79A
13ivig448.9TNF, APOH, SAG, CRP, CD79A
14polyethylene glycol448.9ICAM1, MPO, CD79A, SELE, IFNA2, CRP
15prostacyclin448.9SELE, ICAM1, LTF, CRP, VCAM1, APOH
16pdtc448.9VCAM1, SELE, ITGAX, TNF, ICAM1
17pentoxifylline44 119.9ICAM1, TNF, ITGAM, VCAM1, MPO, LTF
18atorvastatin44 50 28 24 1112.9SELE, ICAM1, CRP, TNF, ITGAM, VCAM1
19simvastatin44 50 61 28 24 1113.8SELE, ITGAM, TNF, CRP, ICAM1, VCAM1
20cyclophosphamide44 50 1110.8VCAM1, MPO, IFNA2, LTF, CRP, APOH
21neopterin448.8CRP, LTF, CD79A, IFNA2, ICAM1, TNF
22vitamin b12448.8LTF, APOH, MPO, CRP, CD79A
23cytochalasin b448.7FCGR3B, ICAM1, PRTN3, MPO, LTF
24infliximab44 50 1110.6PRTN3, SELE, APOH, TNF, CRP, IFNA2
25leukotriene b444 61 2410.4TNF, MPO, ITGAX, ITGAM, LTF, FCGR3B
26endotoxin448.3LTF, CRP, ITGAM, ICAM1, VCAM1, SELE
27polysaccharide448.2ITGAM, CD79A, LTF, VCAM1, SELE, FCGR3B
28azathioprine44 2 50 1111.2LTF, CD79A, APOH, PRTN3, IFNA2, CRP
29ascorbic acid44 249.1CD79A, CRP, MPO, ICAM1, IFNA2, LTF
30mannose448.0CD79A, APOH, FCGR3B, ITGAX, ITGAM, LTF
31rituximab44 50 1110.0CD79A, CRP, IFNA2, TNF, APOH, FCGR3B
32indomethacin44 28 61 1110.9ITGAM, LTF, TNF, MPO, IFNA2, ITGAX
33phosphatidylserine44 28 119.9FCGR3B, PRTN3, CD79A, LTF, APOH, SELE
34lactate447.9VCAM1, ICAM1, ITGAM, CRP, MPO, CD79A
35pge2447.9ICAM1, MPO, TNF, ITGAM, CD79A, VCAM1
36histamine44 28 249.9ITGAM, LTF, CD79A, IFNA2, ICAM1, VCAM1
37n acetylcysteine447.8VCAM1, TNF, MPO, SELE, LTF, CD79A
38genistein44 28 61 2 24 1112.8ITGAM, ICAM1, PRTN3, VCAM1, SELE, FCGR3B
39prednisolone44 28 119.7MPO, APOH, CRP, CD79A, TNF, FCGR3B
40heparin44 28 24 1110.5LTF, VCAM1, APOH, MPO, SELE, SAG
41nitric oxide44 24 119.5MPO, ITGAM, ITGAX, ICAM1, TNF, APOH
42n-formylmethionyl-leucylphenylalanine447.4ITGAM, PRTN3, ITGAX, ICAM1, FCGR3B, MPO
43alanine447.3IFNA2, CRP, CD79A, VCAM1, PRTN3, LTF
44fibrinogen447.3SELE, ICAM1, ITGAX, ITGAM, CD79A, LTF
45vegf447.2APOH, MPO, VCAM1, ICAM1, IFNA2, ITGAM
46fmlp447.2ITGAX, TNF, MPO, ITGAM, LTF, ICAM1
47lipid447.0CRP, APOH, SELE, SAG, TNF, FCGR3B
48oxygen44 248.0PRTN3, SAG, VCAM1, IFNA2, APOH, TNF
49superoxide44 247.8FCGR3B, PRTN3, TNF, APOH, LTF, ITGAM
50retinoic acid44 247.7LTF, ITGAM, MPO, VCAM1, PRTN3, ITGAX

GO Terms for genes affiliated with Vasculitis

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Cellular components related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:0083059.3ITGAM, ITGAX
2membrane raftGO:0451219.2CD79A, SELE, TNF
3external side of plasma membraneGO:0098978.1TNF, VCAM1, ICAM1, ITGAX, ITGAM, CD79A
4extracellular spaceGO:0056158.0LTF, TNF, APOH, MPO, SELE, VCAM1
5plasma membraneGO:0058866.5TNF, FCGR3B, SELE, VCAM1, PRTN3, ICAM1

Biological processes related to Vasculitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.2ICAM1, VCAM1
2negative regulation of lipid storageGO:01088810.1CRP, TNF
3leukocyte tethering or rollingGO:05090110.1VCAM1, SELE, TNF
4heterophilic cell-cell adhesionGO:00715710.1ICAM1, VCAM1, SELE
5negative regulation of growth of symbiont in hostGO:04413010.0MPO, TNF
6response to lipopolysaccharideGO:0324969.9VCAM1, SELE, MPO
7response to ethanolGO:0454719.8CRP, ICAM1, VCAM1
8agingGO:0075689.8MPO, VCAM1, CRP
9positive regulation of NF-kappaB transcription factor activityGO:0510929.7TNF, ICAM1, LTF
10humoral immune responseGO:0069599.6TNF, SH2D1A, LTF
11response to hypoxiaGO:0016669.6CRP, VCAM1, TNF
12inflammatory responseGO:0069549.5TNF, SELE, IFNA2, CRP
13leukocyte cell-cell adhesionGO:0071599.5ITGAM, ICAM1, VCAM1, SELE
14leukocyte migrationGO:0509009.2SELE, ICAM1, ITGAX, ITGAM
15extracellular matrix organizationGO:0301988.9TNF, VCAM1, ICAM1, ITGAX, ITGAM
16cell adhesionGO:0071558.8ITGAM, ITGAX, ICAM1, VCAM1
17blood coagulationGO:0075968.5SELE, IFNA2, ITGAX, ITGAM

Molecular functions related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.2CD79A, ICAM1, SELE
2heparin bindingGO:0082018.8APOH, MPO, ITGAM, LTF
3protein bindingGO:0055156.8ITGAM, LTF, TNF, SH2D1A, APOH, SELE

Products for genes affiliated with Vasculitis

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Sources for Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet