MCID: VSC011
MIFTS: 65

Vasculitis malady

Skin, Cardiovascular categories

Summaries for Vasculitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Vasculitis is an inflammation of the blood vessels. it happens when the body's immune system attacks the blood vessel by mistake. it can happen because of an infection, a medicine, or another disease. the cause is often unknown. vasculitis can affect arteries, veins and capillaries. arteries are vessels that carry blood from the heart to the body's organs. veins are the vessels that carry blood back to the heart. capillaries are tiny blood vessels that connect the small arteries and veins. when a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through close off completely so that blood can't get through stretch and weaken so much that it bulges. the bulge is called an aneurysm. if it bursts, it can cause dangerous bleeding inside the body. symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. the main goal of treatment is to stop the inflammation. steroids and other medicines to stop inflammation are often helpful. nih: national heart, lung, and blood institute

MalaCards: Vasculitis, also known as autoimmune vasculitis, is related to retinal vasculitis and rheumatoid vasculitis. An important gene associated with Vasculitis is SELE (selectin E), and among its related pathways are Immune response Fc epsilon RI pathway and Integrin Pathway. The drug pentoxifylline and the compounds retinoic acid and fibrinogen have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A vascular disease that is an inflammatory destruction of blood vessels.

NIH Rare Diseases:43 Vasculitis is an inflammation of the vascular system, which includes the veins, arteries, and capillaries. there are many different forms of vasculitis, including temporal arteritis, primary angiitis of the central nervous system, takayasu disease, periarteritis nodosa, kawasaki disease, churg-strauss syndrome, wegener granulomatosis, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, sjogren syndrome, behcet disease and others. signs and symptoms of vasculitis vary depending on the form and on the part of the body affected. in general, the cause of vasculitis is thought to be a faulty immune system response. treatment of vasculitis depends upon the specific diagnosis. most of forms of vasculitis respond well to steroid drugs. some may also require treatment with an immunosuppressive drug, such as cyclophosphamide. last updated: 3/12/2009

Wikipedia:64 Vasculitis (plural: vasculitides) is a group of disorders that destroy blood vessels by inflammation.... more...

Aliases & Classifications for Vasculitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin, Cardiovascular


Aliases & Descriptions:

vasculitis 8 43 10 45 34 61
autoimmune vasculitis 43 61
angiitis 8 43
vasculitis, autoimmune 43


External Ids:

Disease Ontology8 DOID:865
MeSH35 D014657
NCIt40 C26912
ICD1025 L95.9

Related Diseases for Vasculitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 640)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vasculitis31.4APOH, SAG
2rheumatoid vasculitis31.2SELE, VCAM1, SRF, LTF, ICAM1
3urticaria31.0SELE, IL1RAPL2
4cryoglobulinemia31.0CD79A, APOH, IFNA2
5hepatitis c30.9SRF, LTF, TNF, IFNA2, IFN1@
6arthritis30.9SELE, SRF, FCGR3B, IL1RAPL2, LTF, PRTN3
7systemic lupus erythematosus30.9SELE, VCAM1, SRF, FCGR3B, IL1RAPL2, CD79A
8polyarteritis nodosa30.7LTF, PRTN3, MPO, IFNA2
9churg-strauss syndrome30.6LTF, PRTN3, MPO
10uveitis30.6TNF, SAG, ICAM1, IFNA2
11nephritis30.6VCAM1, FCGR3B, IL1RAPL2, CD79A, PRTN3, MPO
12cryoglobulinemic vasculitis30.6IFNA2
13rapidly progressive glomerulonephritis30.5PRTN3, MPO, ICAM1
14tuberculosis30.5SRF, IL1RAPL2, CD79A, ITGAM, CTSG, TNF
15wegener's granulomatosis30.5SELE, PRTN3, MPO, CTSG
16polymyalgia rheumatica30.4IL1RAPL2
17hepatitis d30.4SRF, IFNA2
18immunoglobulin a vasculitis30.4VCAM1, CD79A, MPO, ICAM1
19mixed connective tissue disease30.4PRTN3, APOH
20ulcerative colitis30.3SELE, SRF, IL1RAPL2, CD79A, LTF, PRTN3
21acute leukemia30.3PRTN3, MPO, ITGAX, ITGAM
22lupus nephritis30.2VCAM1, CD79A, CTSG, APOH, ICAM1
23antiphospholipid syndrome30.2SELE, VCAM1, CD79A, APOH
24rheumatic disease30.2SRF, APOH, TNF
25mononeuritis multiplex30.2PRTN3, MPO
26eales disease30.2SAG
27vascular disease30.2SELE, VCAM1, PRTN3, ITGAM, APOH, ICAM1
28ankylosing spondylitis30.2SRF, IL1RAPL2, CD79A, PRTN3, TNF
29hepatitis b30.2CD79A, LTF, SAG, IFNA2, IFN1@
30kawasaki disease30.2SELE
31polymyositis30.1SELE, VCAM1, ICAM1
32crohn's disease30.1LTF, TNF
33familial mediterranean fever30.1TNF
34protein s deficiency30.1APOH
35juvenile rheumatoid arthritis30.0SRF, IL1RAPL2, TNF
36amyloidosis30.0IL1RAPL2, CD79A
37thyroiditis30.0CD79A
38arthropathy30.0IL1RAPL2, TNF
39membranoproliferative glomerulonephritis30.0CD79A, IFNA2
40peripheral vascular disease30.0SELE, VCAM1
41atherosclerosis29.9SELE, VCAM1, SRF, IL1RAPL2, PRTN3, MPO
42systemic scleroderma29.9SELE, VCAM1, SRF, FCGR3B, PRTN3, CTSG
43graves' disease29.9SELE, VCAM1, MPO, ICAM1
44leukopenia29.9CD79A, MPO, ITGAM, IFNA2
45bronchiectasis29.9CD79A, MPO, CTSG
46reactive arthritis29.9CD79A, LTF, PRTN3
47sinusitis29.9CD79A, PRTN3
48adenocarcinoma29.9SRF, IL1RAPL2
49goodpasture syndrome29.9MPO
50behcet's disease29.8SELE, APOH, TNF, SAG, IFNA2

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to vasculitis

Clinical Features for Vasculitis

Drugs & Therapeutics for Vasculitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vasculitis

Drug clinical trials:

Search ClinicalTrials for Vasculitis

Search NIH Clinical Center for Vasculitis

Search CenterWatch for Vasculitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Vasculitis

Anatomical Context for Vasculitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vasculitis:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Uterus, Bone marrow, Whole blood, Retina, Heart, Skeletal muscle, Small intestine, Colon, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, Cervix, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Vasculitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Vasculitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.4SELE, ICAM1, TNF, CTSG, ITGAM, ITGAX
2MP:000537611.4TNF, APOH, ITGAM, MPO, SH2D1A, LTF
3MP:000539711.1ITGAX, ITGAM, CTSG, TNF, ICAM1, MPO

Publications for Vasculitis

Sources:
51PubMed
See all sources

Articles related to Vasculitis:

(show top 50)    (show all 2156)
idTitleAuthorsYear
1
Comparison of early (60 min) and delayed (180 min) acquisition of 18F-FDG PET/CT in large vessel vasculitis. (23688731)
2013
2
Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. (22975753)
2013
3
Childhood central nervous system vasculitis. (23608691)
2013
4
Coil Embolization for Spontaneous Rupture of the Left Internal Mammary Artery Secondary to Lupus Vasculitis. (24239665)
2013
5
DRESS syndrome with cerebral vasculitis. (23774556)
2013
6
Biomarkers in ANCA-associated vasculitis. (23955064)
2013
7
Dexamethasone intravitreal implant for idiopathic retinal vasculitis, aneurysms, and neuroretinitis. (23661543)
2013
8
Could we abandon cyclophosphamide in systemic vasculitis and lupus nephritis? (23253917)
2013
9
L12. Rheumatoid arthritis vasculitis. (23481361)
2013
10
Cocaine induced vasculitis: have we found a culprit? (23346447)
2012
11
Persistent fever, neck swelling, and small vessel vasculitis following tonsillectomy in a patient with BehAset's disease: a case report. (23110825)
2012
12
Henoch-SchAPnlein purpura: a rare vasculitis in older adults. (22693696)
2012
13
Rare association of cutaneous vasculitis, IgA nephropathy and antiphospholipid antibody syndrome with tuberculous lymphadenitis. (23295608)
2012
14
Necrotizing scleritis in a patient positive for both c- and p-ANCA without underlying systemic vasculitis. (21792741)
2011
15
Plasmapheresis in diffuse alveolar hemorrhage as perinuclear antineutrophil cytoplasmic antibody-associated vasculitis relapse on hemodialysis. (20609194)
2010
16
Churg-Strauss syndrome: a rare systemic vasculitis. (21078251)
2010
17
Necrotizing lymphocytic vasculitis limited to the peripheral nerves: report of six cases and review. (20204175)
2009
18
Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. (20062624)
2009
19
Two types of myeloperoxidase-antineutrophil cytoplasmic autoantibodies with a high affinity and a low affinity in small vessel vasculitis. (19646343)
2009
20
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. (19467378)
2009
21
A stinging rash of indeterminate origin. Idiopathic hypersensitivity vasculitis. (19235501)
2009
22
Sustained monocyte activation in clinical remission of systemic vasculitis. (18846416)
2008
23
IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis. (16514436)
2006
24
Generalized B-cell non Hodgkin's lymphoma in association with leukocytoclastic vasculitis and disseminated intravascular coagulation. (16638429)
2006
25
Cutaneous leukocytoclastic vasculitis in a child with interleukin-12 receptor beta-1 deficiency. (16615980)
2006
26
Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis. (14740429)
2003
27
Efficacy of corticosteroids and cyclosporin in the treatment of retinal vasculitis in patients with BehAset's disease. (12918765)
2003
28
Cutaneous sinus histiocytosis (Rosai-Dorfman disease) presenting clinically as vasculitis. (12004323)
2002
29
Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (12415593)
2002
30
Contact-system activation in children with vasculitis. (12241658)
2002
31
Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis. (11528520)
2001
32
Cellular steps in pathogenesis of cutaneous necrotizing vasculitis. (10590856)
1999
33
Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2. (10546946)
1999
34
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
35
Radiographic features of central nervous system vasculitis. (9367964)
1997
36
Unilateral choroidal melanoma with bilateral retinal vasculitis. (8942387)
1996
37
Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia. (7574826)
1995
38
Localized vasculitis of the gastrointestinal tract. (7872432)
1995
39
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
40
Unusual DQA-DR haplotypes in rheumatoid vasculitis. (8428242)
1993
41
Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitis. (8318473)
1993
42
Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study. (8462650)
1993
43
Soluble interleukin-2 receptors in retinal vasculitis. (1424745)
1992
44
Disparate roles for TNF in the pathogenesis of acute immune complex alveolitis and dermal vasculitis. (1833107)
1991
45
Immunotactoid glomerulopathy and cutaneous vasculitis. (1904680)
1991
46
Ephedrine-induced intracerebral hemorrhage and central nervous system vasculitis. (2237962)
1990
47
Severe deficiency of alpha 1-antitrypsin associated with cutaneous vasculitis, rapidly progressive glomerulonephritis, and colitis. (3488682)
1986
48
Retinal vasculitis associated with HLA DR4. Brief definitive report. (3875598)
1985
49
Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. (169295)
1975
50
Retinal vasculitis associated with anterior uveitis. (6027626)
1967

Genetic Variations for Vasculitis

Expression for genes affiliated with Vasculitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vasculitis

Search GEO for disease gene expression data for Vasculitis.

Pathways for genes affiliated with Vasculitis

Sources:
12EMD Millipore, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Vasculitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0SH2D1A, ICAM1, FCGR3B, TNF, CD79A, IFNA2
2
Hide members
10.9ITGAM, ITGAX, SRF, VCAM1, ICAM1
310.9FCGR3B, ITGAX, ITGAM, TNF, IFNA2
410.8SELE, ICAM1, TNF, VCAM1
510.8SELE, VCAM1, TNF, ICAM1
610.8ICAM1, TNF, MPO, VCAM1
710.8ITGAM, ICAM1, SELE, VCAM1
810.8MPO, ITGAM, TNF, ICAM1
910.8SRF, TNF, ICAM1, VCAM1
1010.8CD79A, VCAM1, SH2D1A, MPO
1110.7TNF, ICAM1, VCAM1
1210.7VCAM1, TNF, ICAM1
1310.7MPO, TNF, ICAM1
1410.7VCAM1, ITGAM, ICAM1
15
Hide members
10.7ICAM1, ITGAX, VCAM1
1610.7FCGR3B, ICAM1, ITGAM
1710.7ITGAM, ITGAX, SELE
1810.7ITGAM, ITGAX, FCGR3B
1910.6ARR3

Compounds for genes affiliated with Vasculitis

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2413.0CTSG, TNF, ICAM1, IFNA2, ARR3, ITGAM
2fibrinogen4511.9LTF, CD79A, IL1RAPL2, SRF, VCAM1, SELE
3histamine45 29 2413.9IFNA2, ICAM1, TNF, CTSG, ITGAM, MPO
4vegf4511.9ICAM1, ITGAM, APOH, TNF, IFNA2, MPO
5lactate4511.8VCAM1, SELE, SRF, IL1RAPL2, TNF, ICAM1
6nitric oxide45 11 2413.7SELE, CTSG, ITGAM, ITGAX, MPO, VCAM1
7heparin45 29 11 2414.7CD79A, MPO, ITGAM, CTSG, APOH, IL1RAPL2
8fmlp4511.7ICAM1, CTSG, ITGAM, ITGAX, MPO, PRTN3
9superoxide45 2412.7ITGAX, LTF, IL1RAPL2, FCGR3B, VCAM1, ITGAM
10n-formylmethionyl-leucylphenylalanine4511.6CTSG, TNF, ICAM1, PRTN3, MPO, ITGAX
11lipid4511.6IFNA2, PRTN3, FCGR3B, VCAM1, SELE, ITGAM
12serine4511.6TNF, CTSG, SELE, SRF, FCGR3B, IL1RAPL2
13endotoxin4511.6ICAM1, SELE, VCAM1, SRF, LTF, ITGAM
14creatinine4511.5LTF, CD79A, IL1RAPL2, SRF, SELE, MPO
15leukotriene b445 60 2413.5FCGR3B, TNF, CTSG, ITGAM, ITGAX, LTF
16oxygen45 2412.5PRTN3, MPO, ITGAX, ITGAM, TNF, SAG
17mannose4511.5IL1RAPL2, ITGAX, ITGAM, CD79A, FCGR3B, SRF
18n acetylcysteine4511.5ICAM1, ITGAM, SELE, VCAM1, CD79A, LTF
19polysaccharide4511.5SELE, FCGR3B, VCAM1, CD79A, LTF, ITGAM
20prednisolone45 29 1113.5IFNA2, APOH, ITGAM, MPO, CD79A, IL1RAPL2
21h2o24511.5MPO, IL1RAPL2, FCGR3B, CD79A, LTF, ICAM1
22neopterin4511.4IL1RAPL2, CD79A, LTF, TNF, ICAM1, SRF
23genistein45 29 60 2 11 2416.4VCAM1, SELE, TNF, ITGAM, ICAM1, SRF
24prostacyclin4511.4ICAM1, TNF, APOH, CTSG, LTF, VCAM1
25okt34511.4ICAM1, SELE, CD79A, TNF, SRF, VCAM1
26arachidonic acid45 29 11 2414.4ITGAX, IFNA2, SRF, IL1RAPL2, ITGAM, CTSG
278-isoprostane4511.4ICAM1, VCAM1, SELE, TNF, MPO, APOH
28sulfasalazine45 29 50 1114.4IL1RAPL2, MPO, SELE, TNF, CD79A, ICAM1
29cytochalasin b4511.3LTF, ICAM1, FCGR3B, CTSG, MPO, PRTN3
30cyclosporin a45 29 6013.3LTF, ITGAM, TNF, IL1RAPL2, SAG, CD79A
31infliximab45 50 1113.3IL1RAPL2, PRTN3, APOH, TNF, IFNA2, SELE
32rituximab45 50 1113.3CD79A, TNF, FCGR3B, IFNA2, APOH, PRTN3
33pentoxifylline45 1112.3MPO, ITGAM, VCAM1, IL1RAPL2, LTF
34polyethylene glycol4511.3SELE, IL1RAPL2, MPO, ICAM1, IFNA2, CD79A
35apocynin45 6012.2VCAM1, MPO, TNF, SELE, ICAM1
36polymyxin b4511.2ICAM1, SELE, VCAM1, LTF, TNF
37budesonide45 50 1113.2ICAM1, VCAM1, LTF, MPO, TNF
38cytochalasin d45 6012.1VCAM1, ICAM1, ITGAX, LTF, IL1RAPL2, SELE
39indomethacin45 60 29 1114.1LTF, CTSG, IL1RAPL2
40cycloheximide4511.1ITGAX, ITGAM, CTSG, IL1RAPL2
41etanercept45 50 1113.1FCGR3B, IFNA2, TNF, APOH, IL1RAPL2
42simvastatin45 50 60 29 11 2416.0TNF, ICAM1, SELE, VCAM1, ITGAM, IL1RAPL2
43methacholine45 1112.0CD79A, LTF, CTSG, MPO, ICAM1
44cyclophosphamide45 50 1113.0IFNA2, APOH
45pge24511.0SAG
46dextran sulfate4510.9LTF, MPO, APOH, ICAM1
47alanine4510.9LTF, SELE, CD79A, SRF, VCAM1, PRTN3
48ivig4510.8IL1RAPL2, APOH, SAG, CD79A
49adalimumab45 50 1112.8IL1RAPL2, TNF, CD79A, FCGR3B
50gliclazide45 50 1112.7MPO, SELE, VCAM1, ICAM1

GO Terms for genes affiliated with Vasculitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.3TNF, SELE, VCAM1, FCGR3B, CD79A, PRTN3
2extracellular spaceGO:00561511.0SELE, IFNA2, ICAM1, TNF, APOH, CTSG
3external side of plasma membraneGO:00989711.0VCAM1, CD79A, ITGAX, ITGAM, TNF, ICAM1
4secretory granuleGO:03014110.4LTF, MPO, CTSG

Biological processes related to Vasculitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00715911.0ITGAM, ICAM1, VCAM1, SELE
2leukocyte tethering or rollingGO:05090110.8TNF, SELE, VCAM1
3leukocyte migrationGO:05090010.8ITGAX, SELE, ITGAM, ICAM1
4negative regulation of growth of symbiont in hostGO:04413010.8TNF, CTSG, MPO
5membrane to membrane dockingGO:02261410.6VCAM1, ICAM1
6heterophilic cell-cell adhesionGO:00715710.6SELE, VCAM1, ICAM1
7humoral immune responseGO:00695910.4LTF, TNF, SH2D1A

Molecular functions related to Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1opsin bindingGO:00204610.6ARR3, SAG
2heparin bindingGO:00820110.6LTF, MPO, ITGAM, CTSG, APOH

Products for genes affiliated with Vasculitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vasculitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet