MCID: VSC011
MIFTS: 66

Vasculitis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Vasculitis

MalaCards integrated aliases for Vasculitis:

Name: Vasculitis 12 72 49 28 51 40 41 14 59 69
Autoimmune Vasculitis 49 69
Angiitis 12 49
Vasculitis, Autoimmune 49

Classifications:



External Ids:

Disease Ontology 12 DOID:865
MeSH 41 D014657
NCIt 46 C26912

Summaries for Vasculitis

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 52759Disease definitionVasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behçet disease, see this term) to relatively minor skin disease.Visit the Orphanet disease page for more resources. Last updated: 2/10/2014

MalaCards based summary : Vasculitis, also known as autoimmune vasculitis, is related to lymphocytic vasculitis and anca-associated vasculitis, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Heparin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and lung, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A vascular disease that is characterized by inflammation of the blood vessels.

MedlinePlus : 40 Vasculitis is an inflammation of the blood vessels. It happens when the body's immune system attacks the blood vessel by mistake. It can happen because of an infection, a medicine, or another disease. The cause is often unknown. Vasculitis can affect arteries, veins and capillaries. Arteries are vessels that carry blood from the heart to the body's organs. Veins are the vessels that carry blood back to the heart. Capillaries are tiny blood vessels that connect the small arteries and veins. When a blood vessel becomes inflamed, it can Narrow, making it more difficult for blood to get through Close off completely so that blood can't get through Stretch and weaken so much that it bulges. The bulge is called an aneurysm. If it bursts, it can cause dangerous bleeding inside the body. Symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. The main goal of treatment is to stop the inflammation. Steroids and other medicines to stop inflammation are often helpful. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 59
About vasculitis: Vasculitis (vas-kyu-LI-tis) is a condition that involves inflammation in the blood vessels. The condition occurs if your immune system attacks your blood vessels by mistake. This may happen as the result of an infection, a medicine, or another disease or condition.“Inflammation” refers to the body’s response to injury, including injury to the blood vessels. Inflammation may involve pain, redness, warmth, swelling, and loss of function in the affected tissues.In vasculitis, inflammation can lead to serious problems. Complications depend on which blood vessels, organs, or other body systems are affected.

Wikipedia : 72 Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins... more...

Related Diseases for Vasculitis

Diseases related to Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 831)
# Related Disease Score Top Affiliating Genes
1 lymphocytic vasculitis 34.3 ICAM1 SELE VCAM1
2 anca-associated vasculitis 34.3 MPO PRTN3 SERPINA1
3 rheumatoid vasculitis 34.0 CX3CL1 ICAM1 SELE TNF VCAM1
4 central nervous system vasculitis 33.2 CD40LG CRP TNF
5 hypersensitivity vasculitis 32.8 CD40LG CD79A CRP MEFV MPO
6 livedoid vasculopathy 32.6 APOH CD40LG
7 microscopic polyangiitis 32.6 MPO TNF
8 kawasaki disease 32.6 CRP ELANE SELE TNF
9 alpha-1-antitrypsin deficiency 32.4 BPI ELANE SERPINA1
10 temporal arteritis 32.1 APOH CD40LG CRP
11 churg-strauss syndrome 32.0 CD40LG MPO PRTN3 THBD TNF
12 polyarteritis nodosa 31.9 APOH CRP MEFV MPO PRTN3 SELE
13 cryoglobulinemia 31.5 CD40LG CD79A TNFSF13B
14 wegener granulomatosis 30.8 BPI CRP CTSG ELANE MPO PRTN3
15 crescentic glomerulonephritis 30.4 BPI CTSG ICAM1 MPO VCAM1
16 purpura 30.4 APOH CD40LG CD79A CRP THBD TNF
17 immune-complex glomerulonephritis 30.4 ICAM1 MPO VCAM1
18 arthus reaction 30.2 ELANE ICAM1 TNF
19 ulcerative colitis 30.2 BPI CRP MPO PRTN3 TNF
20 endocarditis 30.1 APOH CRP TNF VCAM1
21 pyoderma 30.1 APOH MEFV TNF
22 chorioamnionitis 30.1 CRP ELANE TNF
23 cytomegalovirus infection 30.1 ICAM1 SELE TNF VCAM1
24 erysipelas 30.0 ELANE MEFV TNF
25 familial mediterranean fever 29.9 CRP MEFV TNF
26 infective endocarditis 29.9 APOH CRP TNF
27 rapidly progressive glomerulonephritis 29.9 CD79A CRP ELANE ICAM1 MPO PRTN3
28 mononeuritis multiplex 29.9 CD40LG CRP MPO
29 thrombosis 29.9 APOH THBD VWF
30 pericarditis 29.9 CRP MEFV TNF
31 bronchiectasis 29.8 BPI CTSG ELANE MPO SERPINA1
32 appendicitis 29.8 CRP MPO TNF
33 meningitis 29.8 CD40LG CRP TNF
34 adult-onset still's disease 29.8 CRP MEFV TNF
35 spotted fever 29.8 THBD TNF VWF
36 stroke, ischemic 29.8 APOH CRP THBD VWF
37 glomerulonephritis 29.7 CD40LG CD79A ICAM1 MPO PRTN3 VCAM1
38 connective tissue disease 29.7 APOH CD40LG TNF TNFSF13B
39 reactive arthritis 29.7 BPI CD79A CRP TNF
40 periodontitis 29.6 CRP ELANE TNF
41 spondylitis 29.6 CD40LG CRP TNF
42 pneumonia 29.6 CD40LG CRP ELANE MPO TNF
43 posterior scleritis 29.6 PRTN3 TNF
44 peripheral vascular disease 29.6 CRP SELE THBD VCAM1 VWF
45 erythema multiforme 29.6 CD79A ICAM1 TNF
46 arteriosclerosis 29.5 CRP ICAM1 SELE THBD VCAM1
47 venous insufficiency 29.5 CRP ICAM1 VCAM1 VWF
48 diabetic angiopathy 29.5 SELE THBD VWF
49 behcet syndrome 29.5 APOH CD40LG CD79A CRP MEFV SELE
50 thrombotic thrombocytopenic purpura 29.5 APOH SELE THBD VWF

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to Vasculitis

Symptoms & Phenotypes for Vasculitis

UMLS symptoms related to Vasculitis:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Vasculitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.16 ICAM1 CD40LG MEFV CD79A MPO PRTN3
2 cellular MP:0005384 10.1 SERPINB1 ICAM1 CD40LG MEFV CD79A PRTN3
3 cardiovascular system MP:0005385 10.07 ICAM1 CD40LG MPO CRP SELE CX3CL1
4 homeostasis/metabolism MP:0005376 10.03 SERPINB1 APOH ICAM1 CD40LG MEFV CD79A
5 immune system MP:0005387 9.89 ICAM1 CD40LG MEFV CD79A MPO CRP
6 mortality/aging MP:0010768 9.44 ELANE APOH ICAM1 CD40LG MEFV MPO

Drugs & Therapeutics for Vasculitis

PubMedHealth treatment related to Vasculitis: 59

Treatment for vasculitis will depend on the type of vasculitis you have, which organs are affected, and the severity of the condition.People who have severe vasculitis are treated with prescription medicines. Rarely, surgery may be done. People who have mild vasculitis may find relief with over-the-counter pain medicines, such as acetaminophen, aspirin, ibuprofen, or naproxen.The main goal of treating vasculitis is to reduce inflammation in the affected blood vessels. This usually is done by reducing or stopping the immune response that caused the inflammation.

Drugs for Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 273)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1 9005-49-6 46507594 772
2
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
3
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
4
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
5
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
6
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
7
Azathioprine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 446-86-6 2265
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
10
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 1 216503-57-0
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
12
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
14
Dalteparin Approved Phase 4,Phase 3,Phase 1 9005-49-6
15
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
16
Colchicine Approved Phase 4,Phase 2 64-86-8 2833 6167
17
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
20
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
21
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
22
Glatiramer Acetate Approved, Investigational Phase 4 147245-92-9 3081884
23
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
24
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
25
Anthralin Approved Phase 4 1143-38-0
26
Dapsone Approved, Investigational Phase 4,Phase 2 80-08-0 2955
27
Menthol Approved Phase 4 2216-51-5 16666
28
Pravastatin Approved Phase 4,Phase 2 81093-37-0 54687
29
Ceftazidime Approved Phase 4 72558-82-8, 78439-06-2 5481173
30
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
32 Tocopherol Approved, Investigational, Nutraceutical Phase 4
33
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
34 calcium heparin Phase 4,Phase 3,Phase 1
35 Prednisolone acetate Phase 4,Phase 3,Phase 2
36 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
37 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
38 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
39 Fibrinolytic Agents Phase 4,Phase 3,Phase 1
40 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
41 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
42 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2,Phase 1
43 Micronutrients Phase 4,Phase 3
44 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
45 gamma-Globulins Phase 4,Phase 3,Phase 2,Phase 1
46 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Neuroprotective Agents Phase 4,Phase 2,Phase 3
48 Trace Elements Phase 4,Phase 3
49 Cyclooxygenase Inhibitors Phase 4
50 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 401)

# Name Status NCT ID Phase Drugs
1 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4 azathioprine
2 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4 Alemtuzumab
3 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
5 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4 azathioprine;cyclophosphamide
6 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
7 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
8 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Unknown status NCT01245998 Phase 4 Dalteparin;Dalteparin
9 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
10 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
11 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
12 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
13 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
14 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
15 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
16 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
17 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
18 Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities Completed NCT01456416 Phase 4
19 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
20 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
21 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
22 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
23 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
24 Topical Diclofenac Gel in Patients With Superficial Inflammation of the Veins Completed NCT00377806 Phase 4 Diclofenac gel
25 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
26 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Recruiting NCT02749292 Phase 4 Rituximab
27 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
28 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
29 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
30 A Multi-center, Randomized to Compare the Efficacy of IVIG Alone and IVIG Plus High-dose Aspirin in Kawasaki Disease Recruiting NCT02951234 Phase 4
31 Rituximab for the Otolaryngologic Manifestations of Granulomatosis With Polyangiitis Recruiting NCT02626845 Phase 4 Rituximab
32 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
33 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Active, not recruiting NCT02169219 Phase 4 Glucocorticoids;Rituximab
34 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
35 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Not yet recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
36 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Suspended NCT02115997 Phase 4 Methylprednisolone;Prednisone;Rituximab
37 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4 0,9% NaCl flush;Heparin 50U/ml
38 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
39 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
40 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
41 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
42 Prolonging the Duration of Peripheral Venous Catheters in Cystic Fibrosis People Terminated NCT00418470 Phase 4
43 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3 Azathioprine: 2 mg/kg/day;methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
44 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
45 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
46 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
47 Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change Unknown status NCT00103636 Phase 2, Phase 3
48 Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery Unknown status NCT01297959 Phase 3 E-101 Solution 300 GU/ml;Saline solution
49 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3 infliximab;inactive powder
50 Clinical Trial of Mycophenolate Versus Cyclophosphamide in ANCA Vasculitis Completed NCT00414128 Phase 2, Phase 3 mycophenolate mofetil;cyclophosphamide

Search NIH Clinical Center for Vasculitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: vasculitis

Genetic Tests for Vasculitis

Genetic tests related to Vasculitis:

# Genetic test Affiliating Genes
1 Vasculitis 28

Anatomical Context for Vasculitis

MalaCards organs/tissues related to Vasculitis:

38
Neutrophil, Skin, Lung, Endothelial, T Cells, Heart, B Cells

Publications for Vasculitis

Articles related to Vasculitis:

(show top 50) (show all 2844)
# Title Authors Year
1
Genetics of immunoglobulin-A vasculitis (Henoch-SchAPnlein purpura): An updated review. ( 29353097 )
2018
2
Sweet's Syndrome Mimicking ANCA-Associated Vasculitis. ( 29355513 )
2018
3
Diffuse Alveolar Hemorrhage in IgA Vasculitis with an Atypical Presentation. ( 29033424 )
2018
4
The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. ( 29371340 )
2018
5
Renal Transplantation in Anti-neutrophil Cytoplasmic Antibody Vasculitis. ( 29436872 )
2018
6
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. ( 29447942 )
2018
7
Anti-tubulin-I+-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations. ( 29427009 )
2018
8
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA). ( 29357994 )
2018
9
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
10
EtiologA-a de las vasculitis cutA!neas: utilidad de una aproximaciA^n sistAcmica. ( 29420527 )
2018
11
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis. ( 29447930 )
2018
12
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
13
18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography in Evaluation of Large Vessel Vasculitis. ( 29430115 )
2018
14
Aicardi-GoutiA"res syndrome: cold-induced acral blemish is not always cryoglobulinaemic vasculitis or chilblain lupus. ( 29341198 )
2018
15
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
16
Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study. ( 29419469 )
2018
17
Deficiency of ADA2 mimicking autoimmune lymphoproliferative syndrome in the absence of livedo reticularis and vasculitis. ( 29271561 )
2018
18
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
19
Cutis Laxa Acquisita After Urticarial Vasculitis in SLE Patients. ( 29329127 )
2018
20
Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis. ( 29436199 )
2018
21
Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis. ( 29406049 )
2018
22
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
23
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
24
Ipilimumab induced digital vasculitis. ( 29433584 )
2018
25
Correction: Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial. ( 29358455 )
2018
26
Erythema elevatum diutinum-like vasculitis secondary to cocaine adulterated with levamisole. ( 29423942 )
2018
27
Correction to: Voriconazole-induced periostitis deformans: serial imaging in a patient with ANCA vasculitis. ( 29353405 )
2018
28
MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease. ( 29343815 )
2018
29
Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis. ( 29425799 )
2018
30
Health-related quality of life in ANCA-associated vasculitis and item generation for a disease-specific patient-reported outcome measure. ( 29379322 )
2018
31
Cocaine and ANCA associated vasculitis-like syndromes - A case series. ( 29108823 )
2018
32
Histopathologic Finding of Perieschar Lesions in Tsutsugamushi Disease Shows Lymphocytic Vasculitis Mimicking Angiocentric Lymphoma. ( 29386829 )
2018
33
Histologic Features of Gastrointestinal Tract Biopsies in IgA Vasculitis (Henoch-SchAPnlein Purpura). ( 29438165 )
2018
34
Tubercular retinal vasculitis mimicking frosted branch angiitis: a case report. ( 29356903 )
2018
35
Duodenal Ulcer - IgA Vasculitis. ( 28202872 )
2017
36
Pulmonary Involvement in Antineutrophil Cytoplasmic Antibodies (ANCA)-associated Vasculitis: The Influence of ANCA Subtype. ( 28765242 )
2017
37
Central nervous system vasculitis in a patient with HIV infection: a diagnostic challenge. ( 29236897 )
2017
38
Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review. ( 28733791 )
2017
39
Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls. ( 28870527 )
2017
40
Focal Hemispheric Central Nervous System Vasculitis: An Unusual Form Of Primary Angiitis. ( 28718271 )
2017
41
Long-term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA-associated vasculitis. ( 29247314 )
2017
42
Cutaneous vasculitis: a presentation with endocarditis to keep in mind. ( 28954130 )
2017
43
Persistent Placoid Maculopathy Complicated by Cerebral Vasculitis. ( 28809763 )
2017
44
Characteristics and visual outcome of refractory retinal vasculitis associated with antineutrophil cytoplasm antibody-associated vasculitides. ( 29258731 )
2017
45
Distribution of circulating T follicular helper cell subsets is altered in immunoglobulin A vasculitis in children. ( 29236760 )
2017
46
Adenosine Deaminase 2 Deficiency: More Than Monogenic Vasculitis. ( 28786259 )
2017
47
Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis. ( 28263735 )
2017
48
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. ( 28724375 )
2017
49
Central nervous system vasculitis presenting as an ischaemic stroke in a young woman with systemic sclerosis. ( 28977489 )
2017
50
Stroke Due to Cerebral Vasculitis in a Patient with Relentless Placoid Chorioretinitis. ( 28282738 )
2017

Variations for Vasculitis

Expression for Vasculitis

Search GEO for disease gene expression data for Vasculitis.

Pathways for Vasculitis

Pathways related to Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 BPI CD40LG CD79A CRP CTSG ELANE
2
Show member pathways
13.25 CD40LG ICAM1 PRTN3 TNF TNFSF13B VCAM1
3 12.5 CD40LG CD79A MPO TNF TNFSF13B VCAM1
4
Show member pathways
12.25 BPI CTSG ELANE PRTN3
5
Show member pathways
12.19 CRP ICAM1 MPO TNF
6 12.04 ICAM1 SELE THBD TNF VCAM1
7 11.99 CD40LG ICAM1 SELE VCAM1
8 11.89 CX3CL1 ICAM1 SELE TNF VCAM1
9 11.8 ICAM1 SELE THBD TNF VCAM1
10 11.74 ICAM1 TNF TNFSF13B
11 11.74 CD40LG ICAM1 TNF TNFSF13B VCAM1
12
Show member pathways
11.68 CD40LG TNF TNFSF13B
13 11.64 ELANE MPO PRTN3
14
Show member pathways
11.61 CD40LG TNF TNFSF13B
15 11.54 CD40LG ICAM1 TNF TNFSF13B VCAM1
16 11.46 ELANE ICAM1 MPO TNF
17
Show member pathways
11.45 CD40LG ICAM1 SELE TNF VCAM1
18 11.37 ICAM1 SELE VCAM1
19 11.28 ICAM1 SELE TNF VCAM1
20 11.08 CD40LG CX3CL1 TNF TNFSF13B
21 10.71 CD40LG ICAM1 SELE TNF VCAM1
22 10.66 ICAM1 MPO TNF VCAM1

GO Terms for Vasculitis

Cellular components related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.81 APOH CD40LG CTSG CX3CL1 ELANE ICAM1
2 external side of plasma membrane GO:0009897 9.8 CD40LG CD79A ICAM1 TNF VCAM1
3 extracellular matrix GO:0031012 9.8 APOH CTSG ICAM1 PRTN3 SERPINB1 VWF
4 extracellular region GO:0005576 9.8 APOH BPI CD40LG CRP CTSG CX3CL1
5 membrane raft GO:0045121 9.73 CD79A ICAM1 SELE TNF
6 azurophil granule lumen GO:0035578 9.65 BPI CTSG ELANE MPO PRTN3
7 secretory granule GO:0030141 9.63 CTSG ELANE MPO
8 extracellular space GO:0005615 9.55 APOH BPI CD40LG CRP CTSG CX3CL1
9 extracellular exosome GO:0070062 10.15 APOH BPI CRP CTSG ELANE ICAM1

Biological processes related to Vasculitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.98 CD40LG CRP MEFV SELE TNF
2 immune response GO:0006955 9.97 BPI CD40LG CTSG CX3CL1 TNF TNFSF13B
3 extracellular matrix organization GO:0030198 9.92 ICAM1 TNF VCAM1 VWF
4 regulation of immune response GO:0050776 9.91 CD40LG ICAM1 TNFSF13B VCAM1
5 blood coagulation GO:0007596 9.9 PRTN3 SERPINA1 THBD VWF
6 neutrophil degranulation GO:0043312 9.87 BPI CTSG ELANE MPO PRTN3 SERPINA1
7 leukocyte migration GO:0050900 9.85 ELANE ICAM1 SELE THBD TNF
8 defense response to bacterium GO:0042742 9.83 BPI CTSG ELANE MPO TNF
9 B cell differentiation GO:0030183 9.8 CD40LG CD79A VCAM1
10 positive regulation of T cell proliferation GO:0042102 9.77 CD40LG TNFSF13B VCAM1
11 hemostasis GO:0007599 9.75 SERPINA1 THBD VWF
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.73 ICAM1 SELE VCAM1
13 antimicrobial humoral response GO:0019730 9.67 BPI CTSG ELANE PRTN3
14 defense response to fungus GO:0050832 9.65 CTSG ELANE MPO
15 positive regulation of immune response GO:0050778 9.64 CTSG ELANE
16 negative regulation of fibrinolysis GO:0051918 9.64 APOH THBD
17 negative regulation of lipid storage GO:0010888 9.63 CRP TNF
18 acute inflammatory response to antigenic stimulus GO:0002438 9.62 ELANE ICAM1
19 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 ELANE TNF
20 leukocyte tethering or rolling GO:0050901 9.58 SELE TNF VCAM1
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.57 ICAM1 TNF
22 membrane to membrane docking GO:0022614 9.55 ICAM1 VCAM1
23 regulation of immunoglobulin secretion GO:0051023 9.54 CD40LG TNF
24 response to yeast GO:0001878 9.52 ELANE MPO
25 immunoglobulin secretion GO:0048305 9.51 CD40LG TNFSF13B
26 leukocyte cell-cell adhesion GO:0007159 9.46 CD40LG ICAM1 SELE VCAM1
27 leukocyte migration involved in inflammatory response GO:0002523 9.43 CX3CL1 ELANE SELE
28 negative regulation of growth of symbiont in host GO:0044130 9.26 CTSG ELANE MPO TNF
29 response to lipopolysaccharide GO:0032496 9.17 CTSG ELANE ICAM1 MPO SELE THBD

Molecular functions related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 CD40LG CX3CL1 TNF TNFSF13B
2 heparin binding GO:0008201 9.56 APOH CTSG ELANE MPO
3 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF13B
4 integrin binding GO:0005178 9.26 CX3CL1 ICAM1 VCAM1 VWF
5 protease binding GO:0002020 8.92 ELANE SERPINA1 TNF VWF

Sources for Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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