MCID: VSM001
MIFTS: 35

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 14
Rhinitis, Vasomotor 42 69
Rhinitis Vasomotor 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
ICD10 33 J30.0
MeSH 42 D012223
NCIt 47 C34988
UMLS 69 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to asthma and rhinitis. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are IgA-Producing B Cells in the Intestine and Malaria. The drugs Azelastine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 asthma 28.4 CD40LG RNASE3 TAC1 TLR9 VIP
2 rhinitis 10.9
3 focal hand dystonia 10.6 TAC1 VIP
4 female breast nipple and areola cancer 10.5 CD40LG TAC1
5 chronic erythremia 10.4 CD40LG TAC1
6 sweat gland cancer 10.4 TAC1 VIP
7 oculo-cerebral dysplasia 10.4 CD40LG TLR9
8 wegmann jones smith syndrome 10.3 CALCA VIP
9 central nervous system leiomyosarcoma 10.3 CD40LG TLR9
10 chronic subinvolution of uterus 10.3 CD40LG IL16
11 coarse face hypotonia constipation 10.3 CALCA VIP
12 common cold 10.3 CD40LG TLR9
13 spinal muscular atrophy 10.3 CALCA VIP
14 gastric gastrinoma 10.3 CALCA VIP
15 tularemia 10.3 CD40LG TLR9
16 iris mixed cell melanoma 10.3 CALCA VIP
17 autoimmune disease of cardiovascular system 10.3 CD40LG TLR9
18 dracunculiasis 10.3 CD40LG IL16
19 acute vascular insufficiency of intestine 10.3 CD40LG TLR9
20 cartilage disease 10.3 CALCA TAC1
21 testicular infarct 10.3 CD40LG TLR9
22 kartagener syndrome 10.3 CALCA VIP
23 ostertagiasis 10.3 CD40LG TLR9
24 membranoproliferative glomerulonephritis 10.3 CD40LG TLR9
25 early congenital syphilis 10.3 CD40LG TLR9
26 motor peripheral neuropathy 10.3 CD40LG TLR9
27 hemopericardium 10.3 CALCA TAC1
28 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.3 CD40LG TLR9
29 brain germinoma 10.3 CD40LG TLR9
30 myositis fibrosa 10.3 TAC1 TLR9
31 pediatric supratentorial ependymoma 10.3 CD40LG TLR9
32 intestinal impaction 10.2 CALCA TAC1
33 high pressure neurological syndrome 10.2 CALCA TAC1
34 heart sarcoma 10.2 CD40LG TLR9
35 acute interstitial pneumonia 10.2 CD40LG TLR9
36 endometrial clear cell adenocarcinoma 10.2 TAC1 TLR9
37 hypersomnia 10.2 CALCA TAC1
38 opportunistic bacterial infectious disease 10.2 CD40LG TLR9
39 acute salpingo-oophoritis 10.2 CALCA TAC1
40 hypervitaminosis d 10.2 CD40LG TLR9
41 allergic rhinitis 10.2
42 mesenchymal cell neoplasm 10.2 CD40LG TLR9
43 alternating hemiplegia of childhood 10.1 CALCA TAC1
44 lymphoma 10.1 CD40LG TLR9
45 drug psychosis 10.1 CD40LG TAC1 VIP
46 jackson-weiss syndrome 10.1 CD40LG TLR9
47 pseudoainhum 10.1 RNASE3 TAC1
48 heart septal defect 10.1 CD40LG RNASE3
49 choroidal sclerosis 10.0 CD40LG RNASE3
50 benign shuddering attacks 10.0 CALCA VIP

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azelastine Approved Phase 4 58581-89-8 2267
2
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
3 Analgesics Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Anti-Allergic Agents Phase 4,Phase 3
6 Anti-Asthmatic Agents Phase 4,Phase 3
7 Anti-Inflammatory Agents Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Antirheumatic Agents Phase 4
10 Autonomic Agents Phase 4,Phase 3
11 Bronchodilator Agents Phase 4,Phase 3
12 Histamine Antagonists Phase 4,Phase 3
13 Histamine H1 Antagonists Phase 4,Phase 3
14 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3
15
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
16 Lipoxygenase Inhibitors Phase 4
17 Neurotransmitter Agents Phase 4,Phase 3
18 Olopatadine Hydrochloride Phase 4
19 Peripheral Nervous System Agents Phase 4,Phase 3
20 Respiratory System Agents Phase 4,Phase 3
21
Cetirizine Approved Phase 3 83881-51-0 2678
22
Ephedrine Approved Phase 3 299-42-3 9294
23
Levocetirizine Approved Phase 3 130018-77-8
24
Pseudoephedrine Approved Phase 3 90-82-4 7028
25
Oxymetazoline Approved Phase 3 1491-59-4 4636
26
Phenylephrine Approved Phase 3 59-42-7 6041
27 Adrenergic Agents Phase 3
28 Central Nervous System Stimulants Phase 3
29 Nasal Decongestants Phase 3
30 Vasoconstrictor Agents Phase 3
31 Adrenergic Agonists Phase 3
32 Adrenergic alpha-Agonists Phase 3
33 Mydriatics Phase 3
34 Protective Agents Phase 3
35
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7 4594 9579578
36 Antacids
37 Anti-Ulcer Agents
38 Gastrointestinal Agents
39
Proton pump inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
3 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
4 Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 Study Of Adults And Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED) Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
7 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
8 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
9 PBASE System Idiopathic Rhinitis Clinical Investigation Completed NCT01844336

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

39
Heart

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 198)
id Title Authors Year
1
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. ( 28787742 )
2017
2
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. ( 27277070 )
2016
3
Association between vasomotor rhinitis and irritable bowel syndrome. ( 28683253 )
2016
4
Surgical management of vasomotor rhinitis: A systematic review. ( 25785754 )
2015
5
Vitamin D serum levels in children with allergic and vasomotor rhinitis. ( 26512257 )
2015
6
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. ( 24941668 )
2014
7
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. ( 24433056 )
2014
8
Severe unilateral vasomotor rhinitis: an antecedent sign of vascular compromise? ( 22672492 )
2012
9
Cytologic alterations in nasal mucosa after sphenopalatine artery ligation in patients with vasomotor rhinitis. ( 22391083 )
2012
10
Sphenopalatine artery ligation with nerve resection in patients with vasomotor rhinitis and polyposis: a prospective, randomized, double-blind investigation. ( 22339556 )
2012
11
Traumatic unilateral vasomotor rhinitis. ( 23288805 )
2012
12
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. ( 21352639 )
2011
13
Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. ( 21819751 )
2011
14
Nonallergic rhinopathy (formerlyA known as vasomotor rhinitis). ( 21737036 )
2011
15
Vasomotor rhinitis. ( 20425499 )
2010
16
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to Be Known henceforth as Nonallergic Rhinopathy: Introduction to Part 2. ( 24228749 )
2009
17
Consensus Definition of Nonallergic Rhinopathy, Previously Referred to as Vasomotor Rhinitis, Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24229320 )
2009
18
Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24228856 )
2009
19
Classification of Nonallergic Rhinitis Syndromes With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy. ( 24229372 )
2009
20
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy Part 1. Introduction. ( 24229340 )
2009
21
Characteristics of nonallergic vasomotor rhinitis. ( 24228982 )
2009
22
Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. ( 23282951 )
2009
23
The role of antihistamines in the treatment of vasomotor rhinitis. ( 24228781 )
2009
24
Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. ( 19463202 )
2009
25
Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. ( 19388861 )
2009
26
The treatment of vasomotor rhinitis with intranasal corticosteroids. ( 24228841 )
2009
27
Epidemiology of vasomotor rhinitis. ( 24229078 )
2009
28
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. ( 18446592 )
2008
29
[The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis]. ( 18254318 )
2007
30
Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. ( 17049152 )
2006
31
Nasal wall compliance in vasomotor rhinitis. ( 16141379 )
2006
32
Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. ( 16680922 )
2006
33
The effect of intranasal injection of botulinum toxin A on the symptoms of vasomotor rhinitis. ( 16935174 )
2006
34
CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis. ( 16308253 )
2006
35
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. ( 17087112 )
2006
36
Vasomotor rhinitis. ( 16190503 )
2005
37
Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. ( 15899111 )
2005
38
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis. ( 15799577 )
2005
39
Radiofrequency for the treatment of vasomotor rhinitis. ( 16340279 )
2005
40
Vasomotor rhinitis update. ( 15167037 )
2004
41
Bioavailability and pharmacokinetics of intranasal hydromorphone in patients experiencing vasomotor rhinitis. ( 17523726 )
2004
42
Mechanisms of vasomotor rhinitis. ( 14984550 )
2004
43
Ultrastructural and ultracytochemical study of the human nasal respiratory epithelium in vasomotor rhinitis. ( 14606598 )
2003
44
Vasomotor rhinitis should not be a wastebasket diagnosis. ( 12759277 )
2003
45
Vasomotor rhinitis is not a wastebasket diagnosis. ( 12759275 )
2003
46
Vasomotor rhinitis remains a true clinical problem. ( 12759276 )
2003
47
Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. ( 12141770 )
2002
48
Autonomic dysfunction, vasomotor rhinitis, and extraesophageal manifestations of gastroesophageal reflux. ( 11997777 )
2002
49
Vasomotor rhinitis: clinical efficacy of azelastine nasal spray in comparison with placebo. ( 11244365 )
2001
50
Therapy choices beyond antihistamines. Vasomotor rhinitis. ( 12420500 )
2001

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.8 CD40LG TLR9
2 10.31 CD40LG TLR9

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CALCA CD40LG IL16 RNASE3 TAC1 TLR9
2 extracellular region GO:0005576 9.17 CALCA CD40LG IL16 RNASE3 TAC1 TLR9

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.46 CALCA TAC1
2 cellular response to nerve growth factor stimulus GO:1990090 9.43 CALCA TAC1
3 positive regulation of interleukin-8 production GO:0032757 9.4 CALCA TLR9
4 leukocyte cell-cell adhesion GO:0007159 9.37 CALCA CD40LG
5 positive regulation of interleukin-12 production GO:0032735 9.32 CD40LG TLR9
6 positive regulation of interleukin-10 production GO:0032733 9.26 CD40LG TLR9
7 defense response to Gram-negative bacterium GO:0050829 9.18 TLR9
8 response to pain GO:0048265 9.16 CALCA TAC1
9 positive regulation of ossification GO:0045778 8.96 CALCA TAC1
10 inflammatory response GO:0006954 8.92 CALCA CD40LG TAC1 TLR9

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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