MCID: VSM001
MIFTS: 38

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 14
Rhinitis, Vasomotor 41 69
Rhinitis Vasomotor 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
ICD10 32 J30.0
MeSH 41 D012223
NCIt 46 C34988
UMLS 69 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and irritable bowel syndrome. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are IgA-Producing B Cells in the Intestine and Malaria. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 rhinitis 31.0 RNASE3 TLR9 VIP
2 irritable bowel syndrome 29.8 TAC1 TLR9 VIP
3 asthma 27.7 CALCA CD40LG IL16 RNASE3 TAC1 TLR9
4 anismus 10.4 TAC1 VIP
5 mononeuropathy 10.3 CD40LG TAC1
6 indeterminate leprosy 10.3 CD40LG TAC1
7 allergic rhinitis 10.2
8 constipation 10.2 TAC1 VIP
9 ocular toxoplasmosis 10.2 CD40LG TLR9
10 wdha syndrome 10.2 CALCA VIP
11 leprosy 2 10.2 CALCA VIP
12 central nervous system vasculitis 10.2 CD40LG TLR9
13 inclusion conjunctivitis 10.2 CD40LG IL16
14 cluster headache 10.2 CALCA VIP
15 vipoma 10.2 CALCA VIP
16 pancreatic cholera 10.2 CALCA VIP
17 somatostatinoma 10.2 CALCA VIP
18 coccidiosis 10.2 CD40LG TLR9
19 legionnaires' disease 10.2 CD40LG TLR9
20 autoimmune disease of urogenital tract 10.2 CD40LG TLR9
21 lichen disease 10.2 CD40LG TLR9
22 burn scar 10.2 CALCA TAC1
23 critical illness polyneuropathy 10.2 CD40LG IL16
24 middle ear disease 10.2 CD40LG TLR9
25 islet cell tumor 10.2 CALCA VIP
26 hypersensitivity reaction type iv disease 10.2 CD40LG TLR9
27 extrinsic cardiomyopathy 10.2 CD40LG TLR9
28 exanthem 10.2 CD40LG TLR9
29 opportunistic mycosis 10.2 CD40LG TLR9
30 autonomic nervous system disease 10.1 CALCA TAC1
31 mature b-cell neoplasm 10.1 CD40LG TLR9
32 b cell deficiency 10.1 CD40LG TLR9
33 lymphatic system disease 10.1 CD40LG TLR9
34 brachial plexus lesion 10.1 CALCA TAC1
35 human immunodeficiency virus infectious disease 10.1 CD40LG TLR9
36 complex regional pain syndrome 10.1 CALCA TAC1
37 parasitic protozoa infectious disease 10.1 CD40LG TLR9
38 intestinal disease 10.1 TAC1 TLR9
39 headache 10.1 CALCA TAC1
40 primary bacterial infectious disease 10.1 CD40LG TLR9
41 hemiplegia 10.1 CALCA TAC1
42 bone inflammation disease 10.1 CD40LG TLR9
43 toxoplasmosis 10.1 CD40LG TLR9
44 alternating hemiplegia of childhood 10.1 CALCA TAC1
45 hypersensitivity reaction disease 10.0 CD40LG TLR9
46 cryptosporidiosis 10.0 CD40LG TAC1 VIP
47 prurigo nodularis 10.0 RNASE3 TAC1
48 anxiety 10.0
49 autonomic dysfunction 10.0
50 pfeiffer syndrome 10.0 CD40LG TLR9

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
4 Analgesics Phase 4
5 Respiratory System Agents Phase 4,Phase 3
6 Neurotransmitter Agents Phase 4,Phase 3
7 Analgesics, Non-Narcotic Phase 4
8 Histamine Antagonists Phase 4,Phase 3
9 Histamine H1 Antagonists Phase 4,Phase 3
10 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3
11 Olopatadine Hydrochloride Phase 4
12 Anti-Allergic Agents Phase 4,Phase 3
13 Peripheral Nervous System Agents Phase 4,Phase 3
14 Anti-Asthmatic Agents Phase 4,Phase 3
15 Anti-Inflammatory Agents Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Lipoxygenase Inhibitors Phase 4
18 Autonomic Agents Phase 4,Phase 3
19 Antirheumatic Agents Phase 4
20 Bronchodilator Agents Phase 4,Phase 3
21
Phenylephrine Approved Phase 3 59-42-7 6041
22
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
23
Ephedrine Approved Phase 3 299-42-3 9294
24
Levocetirizine Approved Phase 3 130018-77-8
25
Cetirizine Approved Phase 3 83881-51-0 2678
26
Pseudoephedrine Approved Phase 3 90-82-4 7028
27 Adrenergic Agents Phase 3
28 Central Nervous System Stimulants Phase 3
29 Adrenergic Agonists Phase 3
30 Adrenergic alpha-Agonists Phase 3
31 Mydriatics Phase 3
32 Nasal Decongestants Phase 3
33 Vasoconstrictor Agents Phase 3
34 Protective Agents Phase 3
35
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7 9579578 4594
36 Gastrointestinal Agents
37 Antacids
38 Anti-Ulcer Agents
39 Proton pump inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
3 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
4 Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 Study Of Adults And Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED) Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
7 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
8 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
9 PBASE System Idiopathic Rhinitis Clinical Investigation Completed NCT01844336

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

38
Heart

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 198)
# Title Authors Year
1
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. ( 28787742 )
2017
2
Association between vasomotor rhinitis and irritable bowel syndrome. ( 28683253 )
2016
3
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. ( 27277070 )
2016
4
Vitamin D serum levels in children with allergic and vasomotor rhinitis. ( 26512257 )
2015
5
Surgical management of vasomotor rhinitis: A systematic review. ( 25785754 )
2015
6
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. ( 24941668 )
2014
7
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. ( 24433056 )
2014
8
Sphenopalatine artery ligation with nerve resection in patients with vasomotor rhinitis and polyposis: a prospective, randomized, double-blind investigation. ( 22339556 )
2012
9
Traumatic unilateral vasomotor rhinitis. ( 23288805 )
2012
10
Cytologic alterations in nasal mucosa after sphenopalatine artery ligation in patients with vasomotor rhinitis. ( 22391083 )
2012
11
Severe unilateral vasomotor rhinitis: an antecedent sign of vascular compromise? ( 22672492 )
2012
12
Nonallergic rhinopathy (formerlyA known as vasomotor rhinitis). ( 21737036 )
2011
13
Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. ( 21819751 )
2011
14
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. ( 21352639 )
2011
15
Vasomotor rhinitis. ( 20425499 )
2010
16
Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. ( 19388861 )
2009
17
Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. ( 19463202 )
2009
18
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to Be Known henceforth as Nonallergic Rhinopathy: Introduction to Part 2. ( 24228749 )
2009
19
Classification of Nonallergic Rhinitis Syndromes With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy. ( 24229372 )
2009
20
Consensus Definition of Nonallergic Rhinopathy, Previously Referred to as Vasomotor Rhinitis, Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24229320 )
2009
21
The role of antihistamines in the treatment of vasomotor rhinitis. ( 24228781 )
2009
22
Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24228856 )
2009
23
Characteristics of nonallergic vasomotor rhinitis. ( 24228982 )
2009
24
Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. ( 23282951 )
2009
25
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy Part 1. Introduction. ( 24229340 )
2009
26
Epidemiology of vasomotor rhinitis. ( 24229078 )
2009
27
The treatment of vasomotor rhinitis with intranasal corticosteroids. ( 24228841 )
2009
28
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. ( 18446592 )
2008
29
[The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis]. ( 18254318 )
2007
30
The effect of intranasal injection of botulinum toxin A on the symptoms of vasomotor rhinitis. ( 16935174 )
2006
31
CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis. ( 16308253 )
2006
32
Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. ( 17049152 )
2006
33
Nasal wall compliance in vasomotor rhinitis. ( 16141379 )
2006
34
Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. ( 16680922 )
2006
35
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. ( 17087112 )
2006
36
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis. ( 15799577 )
2005
37
Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. ( 15899111 )
2005
38
Vasomotor rhinitis. ( 16190503 )
2005
39
Radiofrequency for the treatment of vasomotor rhinitis. ( 16340279 )
2005
40
Bioavailability and pharmacokinetics of intranasal hydromorphone in patients experiencing vasomotor rhinitis. ( 17523726 )
2004
41
Vasomotor rhinitis update. ( 15167037 )
2004
42
Mechanisms of vasomotor rhinitis. ( 14984550 )
2004
43
Vasomotor rhinitis remains a true clinical problem. ( 12759276 )
2003
44
Vasomotor rhinitis is not a wastebasket diagnosis. ( 12759275 )
2003
45
Vasomotor rhinitis should not be a wastebasket diagnosis. ( 12759277 )
2003
46
Ultrastructural and ultracytochemical study of the human nasal respiratory epithelium in vasomotor rhinitis. ( 14606598 )
2003
47
Autonomic dysfunction, vasomotor rhinitis, and extraesophageal manifestations of gastroesophageal reflux. ( 11997777 )
2002
48
Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. ( 12141770 )
2002
49
Therapy choices beyond antihistamines. Vasomotor rhinitis. ( 12420500 )
2001
50
Vasomotor rhinitis: clinical efficacy of azelastine nasal spray in comparison with placebo. ( 11244365 )
2001

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 CD40LG TLR9
2 10.31 CD40LG TLR9

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CALCA CD40LG IL16 RNASE3 TAC1 TLR9
2 extracellular region GO:0005576 9.17 CALCA CD40LG IL16 RNASE3 TAC1 TLR9

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.51 RNASE3 TLR9
2 regulation of blood pressure GO:0008217 9.49 CALCA TAC1
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.48 CALCA VIP
4 cellular response to nerve growth factor stimulus GO:1990090 9.46 CALCA TAC1
5 leukocyte cell-cell adhesion GO:0007159 9.43 CALCA CD40LG
6 positive regulation of interleukin-8 production GO:0032757 9.4 CALCA TLR9
7 positive regulation of interleukin-12 production GO:0032735 9.37 CD40LG TLR9
8 positive regulation of interleukin-10 production GO:0032733 9.32 CD40LG TLR9
9 response to pain GO:0048265 9.26 CALCA TAC1
10 regulation of receptor activity GO:0010469 9.26 CALCA CD40LG IL16 VIP
11 positive regulation of ossification GO:0045778 9.16 CALCA TAC1
12 inflammatory response GO:0006954 8.92 CALCA CD40LG TAC1 TLR9

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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