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MCID: VND001

Vein Disease malady
7 genes, 93 related diseases, clinical trials.

Summaries for Vein Disease

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29MalaCards
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MalaCards: Vein Disease, also known as disorder of vein, is related to familial atrial fibrillation and purpura. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are PTM: gamma carboxylation, hypusine formation and arylsulfatase activation and Cell surface interactions at the vascular wall. The compounds spectrozyme and argatroban have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and nervous system.

Aliases & Classifications for Vein Disease

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Sources:
8Disease Ontology, 56UMLS, 25ICD9CM, 52SNOMED-CT, 23ICD10
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Aliases & Descriptions:

vein disease 8
disorder of vein 56

Classifications:


ICD10: 23


External Ids:

Disease Ontology8 DOID:866
ICD9CM25 453
SNOMED-CT52 195435006
ICD1023 I87, I87.8

Related Diseases for Vein Disease

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16GeneCards, 17GeneDecks
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Diseases related to vein disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1familial atrial fibrillation13.5F2
2purpura13.4SERPINC1
3sneddon syndrome13.4SERPINC1
4kidney cancer13.4EPAS1
5cholestasis13.4F2
6hepatitis13.4F2
7acute myocardial infarction13.4SERPINC1
8patent foramen ovale13.4F5
9hepatitis a13.4F2
10retinal artery occlusion13.4F5
11respiratory failure13.3SERPINC1
12ovarian hyperstimulation syndrome13.3F5
13retinal vascular occlusion13.3F5
14coronary thrombosis13.3SERPINC1
15viral hepatitis13.3F2
16factor xii deficiency13.3F5
17factor viii deficiency13.2F5
18vasculitis13.2F2
19nephrotic syndrome13.2SERPINC1
20cerebrovascular disease13.1MTHFR
21rheumatoid arthritis13.1MTHFR
22prostatitis13.1PROS1
23acute leukemia13.0MTHFR
24vitamin k deficiency hemorrhagic disease12.9F2, PROS1
25anemia12.9F2, EPAS1
26thrombocytosis12.9F2, SERPINC1
27leukemia12.9MTHFR
28migraine without aura12.8MTHFR
29meningococcemia12.8SERPINC1, F5
30stroke, ischemic12.8F5, F2
31postphlebitic syndrome12.8SERPINC1, F5
32legg-calve-perthes disease12.8SERPINC1, F5
33sagittal sinus thrombosis12.8SERPINC1, F5
34hypofibrinogenemia, familial12.8F2, SERPINC1
35factor x deficiency12.8F5, F2
36factor v deficiency12.7F5, F2
37factor xi deficiency12.7F2, F5
38von willebrand's disease12.7F5, F2
39afibrinogenemia12.7F2, F5
40venous tributary occlusion of retina12.6F5, SERPINC1
41scott syndrome12.6F2, F5
42eclampsia12.6SERPINC1, MTHFR
43coronary heart disease12.6MTHFR, SERPINC1
44protein s deficiency12.6F5, SERPINC1
45central retinal vein occlusion12.5F5, MTHFR
46atherosclerosis12.5MTHFR, SERPINC1
47liver cirrhosis12.5PROS1, SERPINC1, F2
48purpura fulminans12.5F5, SERPINC1, PROC
49severe pre-eclampsia12.4F5, SERPINC1
50galactosemia12.4F2, SERPINC1

Graphical network of the top 20 diseases related to vein disease:



Diseases related to vein disease

Symptoms for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for vein disease

Drug clinical trials:

Search ClinicalTrials for vein disease

Search NIH Clinical Center for vein disease

Search CenterWatch for vein disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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Animal Models for Vein Disease or affiliated genes

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Sources:
33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to vein disease:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
liver/biliary system phenotype
MP:00053709.5EPAS1, PROS1
2
nervous system phenotype
MP:00036319.4MTHFR, PROS1
3
hematopoietic system phenotype
MP:00053978.7F2, EPAS1, PROS1, PROC
4
cardiovascular system phenotype
MP:00053857.6PROC, PROS1, SERPINC1, EPAS1, F5, F2
5
homeostasis/metabolism phenotype
MP:00053766.8PROC, PROS1, SERPINC1, EPAS1, MTHFR, F5
6
mortality/aging
MP:00107686.4PROC, PROS1, SERPINC1, EPAS1, MTHFR, F5

Publications for Vein Disease

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Sources:
47PubMed
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Articles related to vein disease:

idTitleAuthorsYearAffiliating Genes
1Superficial thrombophlebitis in varicose vein disease : the particular role of methylenetetrahydrofolate reductase. (20881312)Wilmanns C.... Walter P.K.2010F2, PROC, PROS1
2Pathogenic mechanisms in varicose vein disease: the r ole of hypoxia and inflammation. (20632821)Ghaderian S.M.... Akbarzadeh Najar R.2010EPAS1

Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Vein Disease

Pathways for genes affiliated with Vein Disease

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50Reactome, 46PharmGKB, 27KEGG, 34NCBI BioSystems Database, 48QIAGEN, 49R&D Systems
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Pathways related to vein disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation50
9.2F2, PROS1, PROC
2
Cell surface interactions at the vascular wall50
9.2F2, PROS1, PROC
3
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins50
Hide members
9.2F2, PROS1, PROC
4
Complement and coagulation cascades27
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8.0F2, F5, SERPINC1, PROS1, PROC
5
Common Pathway50
Hide members
8.0F2, F5, SERPINC1, PROS1, PROC
6
Blood Coagulation Cascade48
Hide members
8.0PROC, PROS1, SERPINC1, F5, F2
7
Formation of Fibrin Clot (Clotting Cascade)50
Hide members
8.0PROC, PROS1, SERPINC1, F5, F2
8
Platelet activation, signaling and aggregation50
Hide members
8.0PROC, PROS1, SERPINC1, F5, F2

Compounds for genes affiliated with Vein Disease

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Sources:
41Novoseek, 11DrugBank, 22HMDB, 46PharmGKB, 55Tocris Bioscience
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Compounds related to vein disease according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1spectrozyme4110.4SERPINC1
2argatroban41 1111.4SERPINC1
3Sodium Tetradecyl Sulfate1110.1PROC, PROS1
4vitamin k141 2211.0F2
5certoparin419.8F2, SERPINC1
6polybrene419.7F2, SERPINC1
7hepaplastin419.7SERPINC1, F2
8aspirin41 46 2211.7F5, SERPINC1
9eltrombopag469.7F5, SERPINC1
10rivaroxaban41 1110.7F2, SERPINC1
11fibrinopeptide a419.6F2, SERPINC1
12nafamostat mesilate419.6SERPINC1, F5
13batroxobin419.6F5, F2
14Antihemophilic Factor119.6PROC, F2
15organon419.6SERPINC1, F2
16monoethylglycinexylidide419.6F2, F5
17kaolin419.4F5, F2
18phenprocoumon41 46 1111.4SERPINC1, F2
19Drotrecogin alfa119.3F2, F5, PROS1
20inogatran419.3F2, SERPINC1, F5
21hirugen419.3SERPINC1, F2, F5
22ecarin419.3F2, F5, SERPINC1
23danaparoid419.2F5, F2, SERPINC1
24ancrod419.2F2, F5, SERPINC1
25ximelagatran41 1110.2F5, F2, SERPINC1
26heparinoids419.2F2, SERPINC1, F5
27fondaparinux419.2SERPINC1, F5, F2
28bivalirudin41 1110.2F5, SERPINC1, F2
29desogestrel41 1110.2F2, SERPINC1, F5
30protamine sulfate419.2F2, SERPINC1, F5
31gestodene41 1110.2F2, F5, SERPINC1
32ristocetin419.2F2, SERPINC1, F5
33levonorgestrel41 1110.2F2, F5, SERPINC1
34desmopressin41 55 1111.2SERPINC1, F5, F2
35hirudin419.2SERPINC1, F5, F2
36protamine419.2F2, F5, SERPINC1
37dermatan sulfate419.1SERPINC1, F5, F2
38kininogen419.1F2, F5, SERPINC1
39aprotinin41 1110.1F2, F5, SERPINC1
40acenocoumarol41 46 1111.0F2, F5
41gamma-carboxyglutamic acid419.0F2, PROS1, PROC, F5
42polyethylene glycol419.0F5, F2, SERPINC1
435-methyltetrahydrofolate41 119.9MTHFR, F5
44phospholipid418.9PROS1, F5, F2, PROC
45menadione41 11 2210.8F2, PROC, PROS1, MTHFR
46homocysteine41 229.4MTHFR, F2, SERPINC1, F5
47warfarin41 46 11 2211.1SERPINC1, PROC, F2, F5, MTHFR
48fibrinogen418.0F5, MTHFR, SERPINC1, F2, PROC
49creatinine418.0PROS1, SERPINC1, F2, MTHFR, F5
50serine417.5F5, SERPINC1, MTHFR, PROS1, F2, PROC

GO Terms for genes affiliated with Vein Disease

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15Gene Ontology
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Cellular components related to vein disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4F5, PROS1
2Golgi lumenGO:0057969.1F2, PROS1, PROC
3extracellular regionGO:0055767.7PROC, PROS1, SERPINC1, F5, F2

Biological processes related to vein disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.5F2, PROS1
2peptidyl-glutamic acid carboxylationGO:0171879.3F2, PROS1, PROC
3leukocyte migrationGO:0509009.2PROC, PROS1, F2
4post-translational protein modificationGO:0436879.1PROC, PROS1, F2
5blood circulationGO:0080159.0F5, MTHFR
6platelet activationGO:0301688.6F2, F5, PROS1
7blood coagulationGO:0075968.1F2, F5, SERPINC1, PROS1, PROC

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Vein Disease

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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