MCID: VND001
MIFTS: 44

Vein Disease malady

Cardiovascular diseases category

Summaries for Vein Disease

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Sources:
9Disease Ontology, 34MalaCards
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Disease Ontology:9 A vascular disease that is located in a vein.

MalaCards: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and portal vein thrombosis. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Immune response IL 23 signaling pathway and Selenium Pathway. The compounds 5-methyltetrahydrofolate and inogatran have been mentioned in the context of this disorder. Affiliated tissues include a vein, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Vein Disease

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Sources:
9Disease Ontology, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

vein disease 9
disorder of vein 63


External Ids:

Disease Ontology9 DOID:866
ICD9CM28 453
SNOMED-CT59 195435006
ICD1026 I87, I87.8

Related Diseases for Vein Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism29.8F2, MTHFR, F5, PROS1
2portal vein thrombosis29.6F5, MTHFR, F2, PROS1
3hypertension29.6MTHFR, F5, PROS1, F2
4varicose veins10.4
5hepatic vein thrombosis10.1PROS1
6eclampsia10.1MTHFR
7hemophilia b10.1F2
8branch retinal artery occlusion10.1F5
9factor xii deficiency10.1F5
10meningococcemia10.1F5
11purpura fulminans10.0F5, PROC
12sagittal sinus thrombosis10.0F5, PROS1
13homocysteinemia10.0F5, MTHFR
14central retinal vein occlusion10.0F5, MTHFR
15placental abruption10.0MTHFR, F5
16retinal vein occlusion10.0F5, MTHFR
17intracranial thrombosis10.0F5, MTHFR
18vasculitis10.0F2, PROS1
19hellp syndrome10.0F5, MTHFR
20prothrombin deficiency10.0F2, F5
21factor x deficiency10.0F2, F5
22factor v deficiency10.0F2, F5
23factor xi deficiency10.0F2, F5
24liver cirrhosis10.0PROS1, F2
25dysfibrinogenemia10.0F5, F2
26hemorrhagic disease10.0F2, F5
27scott syndrome10.0F2, F5
28von willebrand's disease10.0F2, F5
29factor vii deficiency10.0F5, F2
30factor viii deficiency10.0F2, F5
31homocystinuria10.0F5, MTHFR
32afibrinogenemia10.0F5, F2
33stroke, ischemic10.0MTHFR, F5
34congenital heart disease10.0F2, MTHFR
35disseminated intravascular coagulation10.0F5, PROC, F2
36galactosemia10.0F2, F5
37lupus erythematosus10.0F2, F5, PROS1
38thrombophlebitis10.0
39venous insufficiency10.0
40pregnancy loss9.9F2, F5, MTHFR
41sepsis9.9F5, PROC, F2
42pre-eclampsia9.9MTHFR, F2, F5
43thrombocytopenia9.9F2, F5
44cerebrovascular disease9.9F5, MTHFR, F2
45thromboembolism9.9MTHFR, F5, PROC, F2
46blood protein disease9.9PROS1, F2, MTHFR, F5
47antithrombin iii deficiency9.9F2, PROS1, MTHFR, F5
48protein s deficiency9.9F2, PROS1, F5, MTHFR
49antiphospholipid syndrome9.9F2, PROS1, MTHFR, F5
50hyperhomocysteinemia9.9MTHFR, F5, PROS1, F2

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Symptoms for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Vein Disease

Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Search CenterWatch for Vein Disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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Sources:
15FMA
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FMA organs/tissues related to Vein Disease:

15
A vein

Animal Models for Vein Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Vein Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PROS1, PROC, EPAS1, F2
2MP:00053708.3F5, PROS1, PROC, EPAS1
3MP:00107718.0F2, PROS1, MTHFR, F5
4MP:00053857.8F2, EPAS1, PROC, PROS1, F5
5MP:00053807.8F2, EPAS1, PROS1, F5
6MP:00053787.6F2, EPAS1, PROC, MTHFR, F5
7MP:00036317.3F5, MTHFR, PROS1, PROC, EPAS1, F2
8MP:00053767.3F2, EPAS1, PROC, PROS1, MTHFR, F5
9MP:00107687.3F2, EPAS1, PROC, PROS1, MTHFR, F5

Publications for Vein Disease

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Sources:
53PubMed
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Articles related to Vein Disease:

(show all 36)
idTitleAuthorsYear
1
One-shot scleroembolization: a new technique for the treatment of varicose veins disease of lower extremities. Preliminary results. (23934946)
2013
2
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)
2013
3
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. (22955688)
2013
4
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. (23997567)
2012
5
The significance of upper arm cephalic vein disease in vascular access creation. (23020965)
2012
6
A review of familial, genetic, and congenital aspects of primary varicose vein disease. (22896013)
2012
7
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
8
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. (21262580)
2011
9
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (21690171)
2011
10
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. (21080204)
2011
11
Chronic venous insufficiency: current management of varicose vein disease. (20336886)
2010
12
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. (20227536)
2010
13
Minimally invasive vein surgery: latest options for vein disease. (20506452)
2010
14
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. (20632821)
2010
15
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)
2008
16
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. (17294343)
2007
17
The economics of vein disease. (17911565)
2007
18
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). (18004259)
2007
19
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. (17985316)
2007
20
The histopathology of varicose vein disease. (17067976)
2006
21
Selection of saphenous vein conduit in varicose vein disease. (16564256)
2006
22
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)
2004
23
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
24
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. (12388823)
2002
25
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. (11259188)
2001
26
A unique virus complex causes Ageratum yellow vein disease. (10841581)
2000
27
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)
1999
28
Symptomatology of vein disease. (7728483)
1995
29
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. (1728668)
1992
30
The management of varicose vein disease. (287952)
1979
31
The modern treatment of varicose vein disease. (4520459)
1973
32
Phlebography in varicose vein disease. (5014478)
1972
33
Mesenteric vein disease. (13740328)
1961
34
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. (13843232)
1960
35
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18111784)
1949
36
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18877800)
1948

Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 31KEGG, 52PharmGKB, 55R&D Systems
See all sources

Pathways related to Vein Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.3EPAS1, F2
2
Show member pathways
thioredoxin pathway39
9.3MTHFR, F2
3
Show member pathways
9.2PROS1, F5
4
Show member pathways
9.0PROS1, PROC, F2
5
Show member pathways
9.0F2, PROC, PROS1
6
Show member pathways
9.0PROS1, PROC, F2
7
Show member pathways
8.2F5, PROS1, PROC, F2
8
Show member pathways
8.2F5, PROS1, PROC, F2
9
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.2F2, PROC, PROS1, F5
10
Show member pathways
8.2F2, PROC, PROS1, F5

Compounds for genes affiliated with Vein Disease

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
15-methyltetrahydrofolate46 1210.5MTHFR, F5
2inogatran469.5F5, F2
3cystathionine469.5F5, MTHFR
4ecarin469.5F2, F5
5hirugen469.5F2, F5
6spectrozyme469.5F2, F5
7danaparoid469.5F2, F5
8monoethylglycinexylidide469.4F2, F5
9batroxobin469.4F2, F5
10kaolin469.4F2, F5
11ximelagatran46 1210.4F2, F5
12ancrod469.4F2, F5
13heparinoids469.4F5, F2
14fondaparinux469.4F2, F5
15acenocoumarol46 52 1211.4F2, F5
16bivalirudin46 1210.4F2, F5
17coumarins469.4F2, F5
18desogestrel46 1210.4F2, F5
19argatroban46 1210.4F2, F5
20protamine sulfate469.4F5, F2
21gestodene46 1210.4F2, F5
22vitamin b6469.4MTHFR, F5
23ofloxacin46 3 1211.4F2, F5
24penicillin469.4F5, F2
25antipyrine46 1210.3F5, F2
26ristocetin469.3F5, F2
27cyproteroneacetate469.3F2, F5
28levonorgestrel46 62 30 1212.3F5, F2
29coumarin46 3 52 2512.3F5, F2
30desmopressin46 62 30 1212.3F5, F2
31cardiolipin46 1210.3F2, F5
32hirudin469.2F5, F2
33phosphatidylethanolamine46 1210.2F5, F2
34protamine469.2F2, F5
35dermatan sulfate469.1F5, F2
36kininogen469.0F2, F5
37acetaminophen46 3 52 25 1213.0F5, F2
38metformin46 52 1211.0F5, MTHFR
39homocysteine46 259.9F5, MTHFR, F2
40menadione46 25 1210.9F2, PROC, PROS1, MTHFR
41aspirin46 52 30 2511.9F5, MTHFR, F2
42vitamin b12468.8F5, MTHFR
43gamma-carboxyglutamic acid468.6F5, PROS1, PROC, F2
44phospholipid468.6F2, PROC, PROS1, F5
45aspartate468.6F5, MTHFR, F2
46warfarin46 52 25 1211.5F2, PROC, MTHFR, F5
47fibrinogen468.5F5, MTHFR, PROC, F2
48creatinine468.5F5, MTHFR, PROS1, F2
49heparin46 30 25 1211.1F2, PROC, PROS1, MTHFR, F5
50serine468.1F2, PROC, PROS1, MTHFR, F5

GO Terms for genes affiliated with Vein Disease

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Sources:
17Gene Ontology
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Cellular components related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4PROS1, F2
2platelet alpha granule lumenGO:0310939.1F5, PROS1
3Golgi lumenGO:0057969.0PROS1, PROC, F2
4extracellular regionGO:0055767.9F2, PROC, PROS1, F5

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.4PROS1, F2
2peptidyl-glutamic acid carboxylationGO:0171879.2PROS1, PROC, F2
3platelet degranulationGO:0025769.2F5, PROS1
4leukocyte migrationGO:0509009.2F2, PROC, PROS1
5proteolysisGO:0065089.1PROS1, PROC, F2
6post-translational protein modificationGO:0436879.1F2, PROC, PROS1
7blood circulationGO:0080159.0MTHFR, F5
8cellular protein metabolic processGO:0442678.7PROS1, PROC, F2
9platelet activationGO:0301688.6F5, PROS1, F2
10blood coagulationGO:0075968.4F5, PROS1, PROC, F2

Molecular functions related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055099.0PROS1, PROC, F2
2serine-type endopeptidase activityGO:0042528.3F5, PROC, F2

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet