MCID: VND001
MIFTS: 38

Vein Disease malady

Cardiovascular diseases category

Aliases & Classifications for Vein Disease

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Vein Disease, Aliases & Descriptions:

Name: Vein Disease 9
 
Disorder of Vein 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:866
ICD9CM27 453
SNOMED-CT55 195435006
ICD1025 I87, I87.8

Summaries for Vein Disease

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Disease Ontology:9 A vascular disease that is located in a vein.

MalaCards based summary: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and portal vein thrombosis. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Immune response IL 23 signaling pathway and Selenium Pathway. The compounds 5-methyltetrahydrofolate and inogatran have been mentioned in the context of this disorder. Affiliated tissues include a vein, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Related Diseases for Vein Disease

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Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism29.4F2, PROS1, MTHFR, F5
2portal vein thrombosis29.1F2, PROS1, MTHFR, F5
3varicose veins10.4
4hepatic vein thrombosis10.4PROS1
5eclampsia10.3MTHFR
6hemophilia b10.3F2
7branch retinal artery occlusion10.3F5
8factor xiii deficiency10.3F5
9factor xii deficiency10.3F5
10factor viii deficiency10.3F5
11meningococcemia10.2F5
12sagittal sinus thrombosis10.1PROS1, F5
13homocysteinemia10.1F5, MTHFR
14central retinal vein occlusion10.1MTHFR, F5
15placental abruption10.1F5, MTHFR
16nonarteritic anterior ischemic optic neuropathy10.1F5, MTHFR
17budd-chiari syndrome10.0MTHFR, F5
18retinal vein occlusion10.0MTHFR, F5
19intracranial thrombosis10.0F5, MTHFR
20vasculitis10.0PROS1, F2
21hellp syndrome10.0MTHFR, F5
22hypoprothrombinemia10.0F5, F2
23factor x deficiency10.0F5, F2
24factor v deficiency10.0F2, F5
25factor xi deficiency, autosomal recessive10.0F2, F5
26liver cirrhosis10.0PROS1, F2
27dysfibrinogenemia10.0F2, F5
28hemorrhagic disease10.0F5, F2
29thrombophlebitis10.0
30venous insufficiency10.0
31von willebrand's disease10.0F2, F5
32factor vii deficiency10.0F2, F5
33scott syndrome10.0F2, F5
34hemophilia a10.0F2, F5
35homocystinuria9.9F5, MTHFR
36afibrinogenemia9.9F2, F5
37stroke, ischemic9.9MTHFR, F5
38factor v leiden thrombophilia9.9F5, F2
39congenital heart disease9.9F2, MTHFR
40galactosemia9.9F5, F2
41disseminated intravascular coagulation9.8F2, PROC, F5
42liver disease9.8F5, F2
43chronic venous insufficiency9.8
44hypoxia9.8
45lupus erythematosus9.8F2, PROS1, F5
46thrombophilia due to activated protein c resistance9.8F5, MTHFR, F2
47pregnancy loss, recurrent 19.8F5, MTHFR, F2
48preeclampsia/eclampsia 19.7F2, MTHFR, F5
49thrombocytopenia9.7F5, F2
50thrombophilia due to thrombin defect9.6F2, PROC, MTHFR, F5

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Symptoms for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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FMA organs/tissues related to Vein Disease:

14
A vein

Animal Models for Vein Disease or affiliated genes

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MGI Mouse Phenotypes related to Vein Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PROS1, PROC, EPAS1, F2
2MP:00053708.3F5, PROS1, PROC, EPAS1
3MP:00107718.0F2, PROS1, MTHFR, F5
4MP:00053857.8F2, EPAS1, PROC, PROS1, F5
5MP:00053807.8F2, EPAS1, PROS1, F5
6MP:00053787.6F2, EPAS1, PROC, MTHFR, F5
7MP:00036317.3F5, MTHFR, PROS1, PROC, EPAS1, F2
8MP:00053767.3F2, EPAS1, PROC, PROS1, MTHFR, F5
9MP:00107687.3F2, EPAS1, PROC, PROS1, MTHFR, F5

Publications for Vein Disease

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Articles related to Vein Disease:

(show all 38)
idTitleAuthorsYear
1
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease - ETAV Consensus Meeting 2012. (24534341)
2014
2
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. (25007903)
2014
3
One-shot scleroembolization: a new technique for the treatment of varicose veins disease of lower extremities. Preliminary results. (23934946)
2013
4
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)
2013
5
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. (22955688)
2013
6
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. (23997567)
2012
7
The significance of upper arm cephalic vein disease in vascular access creation. (23020965)
2012
8
A review of familial, genetic, and congenital aspects of primary varicose vein disease. (22896013)
2012
9
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
10
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. (21262580)
2011
11
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (21690171)
2011
12
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. (21080204)
2011
13
Chronic venous insufficiency: current management of varicose vein disease. (20336886)
2010
14
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. (20227536)
2010
15
Minimally invasive vein surgery: latest options for vein disease. (20506452)
2010
16
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. (20632821)
2010
17
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)
2008
18
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. (17294343)
2007
19
The economics of vein disease. (17911565)
2007
20
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). (18004259)
2007
21
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. (17985316)
2007
22
The histopathology of varicose vein disease. (17067976)
2006
23
Selection of saphenous vein conduit in varicose vein disease. (16564256)
2006
24
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)
2004
25
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
26
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. (12388823)
2002
27
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. (11259188)
2001
28
A unique virus complex causes Ageratum yellow vein disease. (10841581)
2000
29
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)
1999
30
Symptomatology of vein disease. (7728483)
1995
31
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. (1728668)
1992
32
The management of varicose vein disease. (287952)
1979
33
The modern treatment of varicose vein disease. (4520459)
1973
34
Phlebography in varicose vein disease. (5014478)
1972
35
Mesenteric vein disease. (13740328)
1961
36
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. (13843232)
1960
37
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18111784)
1949
38
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18877800)
1948

Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

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Pathways related to Vein Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.3EPAS1, F2
2
Show member pathways
thioredoxin pathway36
9.3MTHFR, F2
3
Show member pathways
9.2PROS1, F5
4
Show member pathways
9.0PROS1, PROC, F2
5
Show member pathways
9.0F2, PROC, PROS1
6
Show member pathways
9.0PROS1, PROC, F2
7
Show member pathways
8.2F5, PROS1, PROC, F2
8
Show member pathways
8.2F5, PROS1, PROC, F2
9
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.2F2, PROC, PROS1, F5
10
Show member pathways
8.2F2, PROC, PROS1, F5

Compounds for genes affiliated with Vein Disease

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Compounds related to Vein Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
15-methyltetrahydrofolate43 1210.5MTHFR, F5
2inogatran439.5F5, F2
3cystathionine439.5F5, MTHFR
4ecarin439.5F2, F5
5hirugen439.5F2, F5
6spectrozyme439.5F2, F5
7danaparoid439.5F2, F5
8monoethylglycinexylidide439.4F2, F5
9batroxobin439.4F2, F5
10kaolin439.4F2, F5
11ximelagatran43 1210.4F2, F5
12ancrod439.4F2, F5
13heparinoids439.4F5, F2
14fondaparinux439.4F2, F5
15acenocoumarol43 49 1211.4F2, F5
16bivalirudin43 1210.4F2, F5
17coumarins439.4F2, F5
18desogestrel43 1210.4F2, F5
19argatroban43 1210.4F2, F5
20protamine sulfate439.4F5, F2
21gestodene43 1210.4F2, F5
22vitamin b6439.4MTHFR, F5
23ofloxacin43 2 1211.4F2, F5
24penicillin439.4F5, F2
25antipyrine43 1210.3F5, F2
26ristocetin439.3F5, F2
27cyproteroneacetate439.3F2, F5
28levonorgestrel43 59 28 1212.3F5, F2
29coumarin43 2 49 2412.3F5, F2
30desmopressin43 59 28 1212.3F5, F2
31cardiolipin43 1210.3F2, F5
32hirudin439.2F5, F2
33phosphatidylethanolamine43 1210.2F5, F2
34protamine439.2F2, F5
35dermatan sulfate439.1F5, F2
36kininogen439.0F2, F5
37acetaminophen43 2 49 24 1213.0F5, F2
38metformin43 49 1211.0F5, MTHFR
39homocysteine43 249.9F5, MTHFR, F2
40menadione43 24 1210.9F2, PROC, PROS1, MTHFR
41aspirin43 49 28 2411.9F5, MTHFR, F2
42vitamin b12438.8F5, MTHFR
43gamma-carboxyglutamic acid438.6F5, PROS1, PROC, F2
44phospholipid438.6F2, PROC, PROS1, F5
45aspartate438.6F5, MTHFR, F2
46warfarin43 49 24 1211.5F2, PROC, MTHFR, F5
47fibrinogen438.5F5, MTHFR, PROC, F2
48creatinine438.5F5, MTHFR, PROS1, F2
49heparin43 28 24 1211.1F2, PROC, PROS1, MTHFR, F5
50serine438.1F2, PROC, PROS1, MTHFR, F5

GO Terms for genes affiliated with Vein Disease

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Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.4PROS1, F2
2platelet alpha granule lumenGO:00310939.1F5, PROS1
3Golgi lumenGO:00057969.0PROS1, PROC, F2
4extracellular regionGO:00055767.9F2, PROC, PROS1, F5

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:00427309.4PROS1, F2
2peptidyl-glutamic acid carboxylationGO:00171879.2PROS1, PROC, F2
3platelet degranulationGO:00025769.2F5, PROS1
4leukocyte migrationGO:00509009.2F2, PROC, PROS1
5proteolysisGO:00065089.1PROS1, PROC, F2
6post-translational protein modificationGO:00436879.1F2, PROC, PROS1
7blood circulationGO:00080159.0MTHFR, F5
8cellular protein metabolic processGO:00442678.7PROS1, PROC, F2
9platelet activationGO:00301688.6F5, PROS1, F2
10blood coagulationGO:00075968.4F5, PROS1, PROC, F2

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00055099.0PROS1, PROC, F2
2serine-type endopeptidase activityGO:00042528.3F5, PROC, F2

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Vein Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet