Vein Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Vein Disease

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³²MalaCards
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MalaCards: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and vascular disease. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Cell surface interactions at the vascular wall and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds serine and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and endothelial, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Vein Disease

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ²⁷ICD9CM, ⁵⁶SNOMED-CT, ²⁵ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases

ICD10: ²⁵

Diseases of the circulatory system

Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified

Other disorders of veins

Other specified disorders of veins

Aliases & Descriptions:

vein disease ⁸

disorder of vein ⁶⁰

External Ids:

Disease Ontology⁸ DOID:866

ICD9CM²⁷ 453

SNOMED-CT⁵⁶ 195435006

ICD10²⁵ I87, I87.8

UMLS⁶⁰ C0155774

Related Diseases for Vein Disease

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 88)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary embolism	29.9	F5, MTHFR, PROS1, F2, SERPINC1
2	vascular disease	29.7	SERPINC1, MTHFR, F5
3	hypertension	29.7	F2, PROS1, MTHFR, F5
4	thrombophlebitis	10.0
5	hepatic vein thrombosis	10.0	PROS1
6	varicose veins	10.0	F2
7	purpura	10.0	SERPINC1
8	sneddon syndrome	10.0	SERPINC1
9	cholestasis	10.0	F2
10	kidney cancer	10.0	EPAS1
11	hepatitis	10.0	F2
12	acute myocardial infarction	10.0	SERPINC1
13	hepatitis a	10.0	F2
14	respiratory failure	10.0	SERPINC1
15	vitamin k deficiency hemorrhagic disease	10.0	F2
16	cerebrovascular disease	10.0	MTHFR
17	rheumatoid arthritis	10.0	MTHFR
18	viral hepatitis	10.0	F2
19	coronary thrombosis	10.0	SERPINC1
20	prostatitis	10.0	PROS1
21	neural tube defects	10.0	MTHFR
22	acute leukemia	10.0	MTHFR
23	nephrotic syndrome	10.0	SERPINC1
24	patent foramen ovale	10.0	F5
25	ovarian hyperstimulation syndrome	10.0	F5
26	branch retinal artery occlusion	10.0	F5
27	retinal vascular occlusion	10.0	F5
28	leukemia	10.0	MTHFR
29	factor xii deficiency	10.0	F5
30	factor viii deficiency	10.0	F5
31	migraine	10.0	MTHFR
32	vasculitis	10.0	F2, PROS1
33	hepatitis c	10.0	F2
34	thrombocytosis	10.0	SERPINC1, F2
35	deficiency anemia	10.0	F2, EPAS1
36	eclampsia	10.0	SERPINC1, MTHFR
37	coronary heart disease	10.0	MTHFR, SERPINC1
38	atherosclerosis	10.0	SERPINC1, MTHFR
39	colorectal cancer	10.0	MTHFR, PROS1
40	hepatocellular carcinoma	10.0	EPAS1, F2
41	meningococcemia	10.0	F5, SERPINC1
42	stroke, ischemic	10.0	F5, F2
43	postphlebitic syndrome	10.0	F5, SERPINC1
44	legg-calve-perthes disease	10.0	F5, SERPINC1
45	factor x deficiency	10.0	F5, F2
46	central retinal vein occlusion	10.0	MTHFR, F5
47	factor v deficiency	10.0	F5, F2
48	homocysteinemia	10.0	MTHFR, F5
49	liver cirrhosis	10.0	PROS1, F2, SERPINC1
50	factor xi deficiency	10.0	F5, F2

Graphical network of the top 20 diseases related to Vein Disease:

Clinical Features for Vein Disease

Drugs & Therapeutics for Vein Disease

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Vein Disease

Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Search CenterWatch for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Vein Disease:

³²

Liver, Heart, Endothelial, Smooth muscle, Bone, Lung, Thyroid, Brain, Bone marrow

Animal Models for Vein Disease or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Vein Disease:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	10.0	F2
2	hematopoietic system phenotype	MP:0005397	8.2	SERPINC1, F2, EPAS1, PROC, PROS1
3	liver/biliary system phenotype	MP:0005370	7.8	F5, PROS1, PROC, EPAS1, SERPINC1
4	embryogenesis phenotype	MP:0005380	7.4	F5, PROS1, EPAS1, F2, SERPINC1
5	nervous system phenotype	MP:0003631	6.9	SERPINC1, F5, MTHFR, PROS1, PROC, EPAS1
6	homeostasis/metabolism phenotype	MP:0005376	6.9	F5, MTHFR, PROS1, PROC, EPAS1, F2
7	mortality/aging	MP:0010768	6.7	F5, MTHFR, PROS1, PROC, EPAS1, F2

Publications for Vein Disease

Sources:
⁵⁰PubMed
See all sources

Articles related to Vein Disease:

(show top 50) (show all 207)

id	Title	Authors	Year
1	Re. 'Left Renal Vein Division During Open Surgery of Abdominal Aortic Disease: A Propensity Score-matched Case-control Study'. (24215728)	Davidovic L.... Banzic I.	2014
2	Intra-jugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice. (24390280)	Dufour B.D.... McBride J.L.	2014
3	Simultaneous management of renal carcinoma with caval vein thrombosis and double coronary artery disease. (24399123)	Grasso M.... Grasso A.A.	2013
4	Cystic adventitial disease of the common femoral vein: a case report and review of the literature. (23873672)	Mousa A.Y.... AbuRahma A.F.	2013
5	Rheological properties of young and aged erythrocytes in chronic venous disease patients with varicose veins. (23594503)	SA8oczyA8ska K.... Marona H.	2013
6	Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. (23071133)	de Vries M.R.... Quax P.H.	2013
7	Impact of Extracardiac Vascular Disease on Vein Graft Failure and Outcomes After Coronary Artery Bypass Surgery. (24360877)	Harskamp R.E.... Lopes R.D.	2013
8	Minimally invasive, endovenous laser treatment of varicose veins in patients with von Willebrand disease. (24364473)	Terlecki P.... KuczyA8ski M.	2013
9	Thrombosis in BehAset's disease: a BehAset's disease patient with complete thrombotic obstruction of IVC and both iliac veins and decreased protein S activity. (22200809)	Jeong H.... Jo W.M.	2013
10	Adventitial cystic disease of the common femoral vein presenting as deep vein thrombosis. (23978427)	Kim Y.K.... Moon I.S.	2013
11	Left renal vein division during open surgery of abdominal aortic disease: a propensity score-matched case-control study. (23743276)	Wang L.... Zhang J.	2013
12	Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)	Thekke-Veetil T.... Tzanetakis I.E.	2013
13	Mid- and long-term results of the treatment of infrainguinal arterial occlusive disease with precuffed expanded polytetrafluoroethylene grafts compared with vein grafts. (22998787)	Loh S.A.... Maldonado T.S.	2013
14	Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. (22944580)	Komai H.... Nagao T.	2012
15	Bilateral disease and early age at presentation are associated with shorter survival in patients with congenital heart disease and intraluminal pulmonary vein stenosis. (22469299)	Balasubramanian S.... Jenkins K.J.	2012
16	Obstruction of the superior vena cava and stenosis of the right brachiocephalic vein in a patient with Adamantiades-Behcet's disease. (24391429)	Zacharias G.... Avgerinos P.C.	2011
17	Patient-reported symptoms are independent of disease severity in patients with primary varicose veins. (21821663)	Conway A.M.... Loftus I.M.	2011
18	Midterm results of autologous saphenous vein and ePTFE pre-cuffed bypass surgery in peripheral arterial occlusive disease. (21757494)	Donker J.M.... van der Laan L.	2011
19	Survival among children with portal vein thrombosis and end-stage liver disease. (19413719)	Al-Holou S.... Englesbe M.J.	2010
20	Macular ischaemia after intravitreal bevacizumab injection in patients with central retinal vein occlusion and a history of diabetes and vascular disease. (20215378)	Shimura M.... Yasuda K.	2010
21	Pre-existent portal vein thrombosis in liver transplantation: influence of pre-operative disease severity. (19236435)	Doenecke A.... Obed A.	2010
22	Thrombosis of temporal artery and renal vein in Kimura-disease-related nephrotic syndrome. (18066701)	Danis R.... Kilinc I.	2009
23	Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with BehAset disease involving superficial vein thrombophlebitis. (19221262)	Kawakami T.... Soma Y.	2009
24	Portal vein thrombosis in adult-onset Still's disease: a case report and literature review. (19306000)	Morita H.... Yoshimura A.	2009
25	Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease. (19047778)	Wakisaka Y.... Kitamura S.	2009
26	Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)	Unal A.... Utas C.	2008
27	Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)	Sasaya T.... Koganezawa H.	2008
28	Disclosure of a financial relationship relating to "surgery for paroxysmal atrial fibrillation in the setting of mitral valve disease: a role for pulmonary vein isolation. Ann Thorac Surg 2006;81:19-28". (16488760)	Gillinov A.M.... McCarthy P.M.	2006
29	Reversal of left atrial-pulmonary vein remodeling in hypertensive heart disease. (16903973)	Bozkaya Y.T.... Hasdemir C.	2006
30	Nonischemic central retinal vein occlusion associated with celiac disease. (15704767)	Lee E.S.... Pulido J.S.	2005
31	Hypertension and hypertensive heart disease are associated with increased ostial pulmonary vein diameter. (15673377)	Herweg B.... Steinberg J.S.	2005
32	The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)	Saunders K.... Stanley J.	2004
33	Isolation of the pulmonary veins in patients with permanent atrial fibrillation secondary to mitral valve disease. (15320554)	Lima G.G.... Nesralla I.A.	2004
34	Portal vein thrombosis following laparoscopic surgery in a patient with sickle cell disease. (15765550)	Ng P.C.... Ashari L.	2003
35	Thrombophilic genotypes, natural anticoagulants, and plasma homocysteine in myeloproliferative disorders: relationship with splanchnic vein thrombosis and arterial disease. (12555209)	Amitrano L.... Balzano A.	2003
36	Pulmonary vein stenosis mimicking chronic lung disease. (12892169)	Chakrabarti S.... Gnanapragasam J.P.	2003
37	Gene therapy for all aspects of vein-graft disease. (12643467)	White S.J.... Newby A.C.	2002
38	Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)	Saunders K.... Stanley J.	2002
39	Peyronie's disease: corporoplasty using saphenous vein patch graft. (11834897)	Porena M.... Zucchi A.	2002
40	Diameter comparison of saphenous vein bypasses for popliteal aneurysm versus peripheral arterial occlusive disease in matched subjects. (16222384)	Moore J.... Beebe H.G.	2001
41	Portal vein and bone involvement in disseminated cat-scratch disease: report of 2 cases. (11017839)	Ruess M.... Berner R.	2000
42	A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)	Saunders K.... Stanley J.	1999
43	PD156707: a potent antagonist of endothelin-1 in human diseased coronary arteries and vein grafts. (9595448)	Maguire J.J.... Davenport A.P.	1998
44	The presence of higher levels of thyroglobulin, but not thyroid autoantibodies, in the thyroid vein in Graves' disease. (7911812)	Chou F.F.... Sheen-Chen S.M.	1994
45	Recurrence of cystic adventitial disease in an interposed vein graft. (8079189)	Ohta T.... Tsuchioka H.	1994
46	Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. (8272217)	Pedersen E.B.... Nielsen C.B.	1993
47	Cytokeratins 8 and 18 in smooth muscle cells. Detection in human coronary artery, peripheral vascular, and vein graft disease and in transplantation-associated arteriosclerosis. (7692956)	Jahn L.... Izumo S.	1993
48	The effect of caffeine on renal vein renin concentration in patients with renal arterial disease. (1815652)	Postma C.T.... Thien T.	1991
49	Veno-occlusive disease and primary hepatic vein thrombosis in Israeli Arabs. (7263190)	Ghanem J.... Hershko C.	1981
50	Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)	SCHEINKER I.M.	1945

Genes related to Vein Disease

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Vein Disease:

id	Symbol	Description	Score	Implication
1	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	21.30	GeneCards inferred : Publications, Disorders (show sections)
2	PROS1	protein S (alpha)	18.45	GeneCards inferred : Publications, Disorders (show sections)
3	EPAS1	endothelial PAS domain protein 1	15.59	GeneCards inferred : Publications, Disorders (show sections)
4	F2	coagulation factor II (thrombin)	12.73	GeneCards inferred : Publications, Disorders (show sections)
5	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	9.87	GeneCards inferred : Publications, Disorders (show sections)
6	F5	coagulation factor V (proaccelerin, labile factor)	7.02	GeneCards inferred : Publications, Disorders (show sections)
7	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	4.16	GeneCards inferred : Disorders (show sections)

Products for genes related to Vein Disease disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	7	7	7
2	LSBio	-	-	7

Genetic Variations for Vein Disease

Expression for genes affiliated with Vein Disease

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

Sources:
⁵³Reactome, ⁴⁹PharmGKB, ⁵¹QIAGEN, ⁵²R&D Systems, ³⁷NCBI BioSystems Database, ²⁹KEGG
See all sources

Pathways related to Vein Disease according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Cell surface interactions at the vascular wall⁵³	9.2	F2, PROC, PROS1
2	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins⁵³ Hide members Removal of aminoterminal propeptides from gamma-carboxylated proteins⁵³ Warfarin Pathway, Pharmacodynamics⁴⁹ Gamma-carboxylation of protein precursors⁵³ Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus⁵³	9.2	F2, PROC, PROS1
3	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation⁵³	9.2	PROS1, PROC, F2
4	Platelet activation, signaling and aggregation⁵³ Hide members Hemostasis⁵³	8.9	PROC, PROS1, F5
5	Collagen biosynthesis and modifying enzymes⁵³ Hide members Blood Coagulation Cascade⁵¹ Intrinsic Prothrombin Activation Pathway⁵¹	7.8	F5, PROS1, PROC, F2, SERPINC1
6	Formation of Fibrin Clot (Clotting Cascade)⁵³ Hide members Blood Coagulation Signaling Pathways⁵² Intrinsic Pathway⁵³ Blood Clotting Cascade³⁷	7.8	F5, PROS1, PROC, F2, SERPINC1
7	Complement and coagulation cascades²⁹ Hide members Complement and Coagulation Cascades³⁷	7.8	SERPINC1, F2, PROC, PROS1, F5
8	Common Pathway⁵³ Hide members Extrinsic Prothrombin Activation Pathway⁵¹	7.8	SERPINC1, F2, PROC, PROS1, F5

Compounds for genes affiliated with Vein Disease

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁴⁹PharmGKB, ²⁴HMDB, ²⁸IUPHAR, ⁵⁹Tocris Bioscience, ²BitterDB
See all sources

Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50) (show all 81)

id	Compound	Score	Top Affiliating Genes
1	serine⁴⁴	10.4	PROS1
2	Sodium Tetradecyl Sulfate¹¹	10.0	PROC, PROS1
3	warfarin⁴⁴ ⁴⁹ ¹¹ ²⁴	13.0	SERPINC1, PROC
4	monoethylglycinexylidide⁴⁴	9.9	F5
5	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.9	MTHFR, PROS1
6	certoparin⁴⁴	9.8	SERPINC1, F2
7	polybrene⁴⁴	9.7	SERPINC1, F2
8	fibrinopeptide a⁴⁴	9.7	F2, SERPINC1
9	hepaplastin⁴⁴	9.6	F2, SERPINC1
10	organon⁴⁴	9.5	F2, SERPINC1
11	rivaroxaban⁴⁴ ¹¹	10.4	F2, SERPINC1
12	aprotinin⁴⁴ ¹¹	10.4	SERPINC1, F5
13	batroxobin⁴⁴	9.4	F5, F2
14	vitamin k1⁴⁴ ²⁴	10.3	F2, SERPINC1
15	nafamostat mesilate⁴⁴	9.3	F5, SERPINC1
16	kaolin⁴⁴	9.3	F5, F2
17	eltrombopag⁴⁹ ¹¹	10.2	F5, SERPINC1
18	Drotrecogin alfa¹¹	9.1	F5, PROS1, F2
19	acenocoumarol⁴⁴ ⁴⁹ ¹¹	11.1	F2, F5
20	inogatran⁴⁴	9.1	SERPINC1, F2, F5
21	hirugen⁴⁴	9.1	SERPINC1, F2, F5
22	ecarin⁴⁴	9.1	SERPINC1, F2, F5
23	spectrozyme⁴⁴	9.0	F5, F2, SERPINC1
24	danaparoid⁴⁴	9.0	SERPINC1, F2, F5
25	ancrod⁴⁴	9.0	F5, F2, SERPINC1
26	ximelagatran⁴⁴ ¹¹	10.0	F5, F2, SERPINC1
27	heparinoids⁴⁴	9.0	F5, F2, SERPINC1
28	fondaparinux⁴⁴	9.0	SERPINC1, F2, F5
29	bivalirudin⁴⁴ ¹¹	10.0	F5, F2, SERPINC1
30	argatroban⁴⁴ ¹¹	10.0	F5, F2, SERPINC1
31	desogestrel⁴⁴ ¹¹	10.0	F5, F2, SERPINC1
32	protamine sulfate⁴⁴	9.0	F5, F2, SERPINC1
33	gestodene⁴⁴ ¹¹	10.0	SERPINC1, F2, F5
34	ristocetin⁴⁴	9.0	SERPINC1, F2, F5
35	levonorgestrel⁴⁴ ⁵⁹ ²⁸ ¹¹	12.0	SERPINC1, F2, F5
36	coumarin⁴⁴ ² ⁴⁹ ²⁴	12.0	F5, F2, SERPINC1
37	desmopressin⁴⁴ ⁵⁹ ²⁸ ¹¹	12.0	F5, F2, SERPINC1
38	menadione⁴⁴ ¹¹ ²⁴	11.0	F2, PROC, PROS1, MTHFR
39	hirudin⁴⁴	9.0	F5, F2, SERPINC1
40	protamine⁴⁴	8.9	SERPINC1, F2, F5
41	dermatan sulfate⁴⁴	8.9	F5, F2, SERPINC1
42	kininogen⁴⁴	8.9	SERPINC1, F2, F5
43	polyethylene glycol⁴⁴	8.9	F5, F2, SERPINC1
44	gamma-carboxyglutamic acid⁴⁴	8.8	F5, PROS1, PROC, F2
45	5-methyltetrahydrofolate⁴⁴ ¹¹	9.7	MTHFR, F5
46	phospholipid⁴⁴	8.7	F5, PROS1, PROC, F2
47	homocysteine⁴⁴ ²⁴	9.4	F5, MTHFR, F2, SERPINC1
48	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	11.3	F5, MTHFR, F2, SERPINC1
49	fibrinogen⁴⁴	8.0	F5, MTHFR, PROC, F2, SERPINC1
50	creatinine⁴⁴	8.0	F5, MTHFR, PROS1, F2, SERPINC1

GO Terms for genes affiliated with Vein Disease

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Vein Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.2	PROS1, F5
2	Golgi lumen	GO:005796	9.1	F2, PROC, PROS1
3	extracellular region	GO:005576	7.5	F5, PROS1, PROC, F2, SERPINC1

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibrinolysis	GO:042730	9.6	PROS1, F2
2	negative regulation of endopeptidase activity	GO:010951	9.5	SERPINC1, PROS1
3	peptidyl-glutamic acid carboxylation	GO:017187	9.3	F2, PROC, PROS1
4	leukocyte migration	GO:050900	9.3	F2, PROC, PROS1
5	post-translational protein modification	GO:043687	9.2	F2, PROC, PROS1
6	blood circulation	GO:008015	8.7	MTHFR, F5
7	platelet activation	GO:030168	8.6	F5, PROS1, F2
8	blood coagulation	GO:007596	8.0	F5, PROS1, PROC, F2, SERPINC1