MCID: VND001
MIFTS: 42

Vein Disease malady

Cardiovascular category

Summaries for Vein Disease

Sources:
33MalaCards
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MalaCards: Vein Disease, also known as disorder of vein, is related to varicose veins and vascular disease. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Cell surface interactions at the vascular wall and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds serine and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Vein Disease

Sources:
8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

vein disease 8
disorder of vein 61


External Ids:

Disease Ontology8 DOID:866
ICD9CM27 453
SNOMED-CT57 195435006
ICD1025 I87, I87.8

Related Diseases for Vein Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1varicose veins29.8F2
2vascular disease29.8F5, MTHFR, SERPINC1
3thrombophlebitis10.0
4hepatic vein thrombosis10.0PROS1
5purpura10.0SERPINC1
6sneddon syndrome10.0SERPINC1
7cholestasis10.0F2
8kidney cancer10.0EPAS1
9hepatitis10.0F2
10acute myocardial infarction10.0SERPINC1
11hepatitis a10.0F2
12respiratory failure10.0SERPINC1
13vitamin k deficiency hemorrhagic disease10.0F2
14cerebrovascular disease10.0MTHFR
15rheumatoid arthritis10.0MTHFR
16viral hepatitis10.0F2
17coronary thrombosis10.0SERPINC1
18prostatitis10.0PROS1
19neural tube defects10.0MTHFR
20acute leukemia10.0MTHFR
21nephrotic syndrome10.0SERPINC1
22patent foramen ovale10.0F5
23ovarian hyperstimulation syndrome10.0F5
24branch retinal artery occlusion10.0F5
25retinal vascular occlusion10.0F5
26leukemia10.0MTHFR
27factor xii deficiency10.0F5
28factor viii deficiency10.0F5
29migraine10.0MTHFR
30vasculitis10.0PROS1, F2
31hepatitis c10.0F2
32thrombocytosis10.0F2, SERPINC1
33deficiency anemia10.0F2, EPAS1
34eclampsia10.0SERPINC1, MTHFR
35coronary heart disease10.0SERPINC1, MTHFR
36atherosclerosis10.0SERPINC1, MTHFR
37colorectal cancer10.0PROS1, MTHFR
38hepatocellular carcinoma10.0F2, EPAS1
39meningococcemia10.0F5, SERPINC1
40stroke, ischemic10.0F2, F5
41postphlebitic syndrome10.0F5, SERPINC1
42legg-calve-perthes disease10.0SERPINC1, F5
43factor x deficiency10.0F5, F2
44central retinal vein occlusion10.0F5, MTHFR
45factor v deficiency10.0F2, F5
46homocysteinemia10.0F5, MTHFR
47liver cirrhosis10.0F2, PROS1, SERPINC1
48factor xi deficiency10.0F5, F2
49von willebrand's disease10.0F5, F2
50afibrinogenemia10.0F2, F5

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Clinical Features for Vein Disease

Drugs & Therapeutics for Vein Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Vein Disease

Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Search CenterWatch for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vein Disease:

33
Liver, Brain, Lung, Bone marrow, Heart, Smooth muscle, Thyroid, T cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Vein Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Vein Disease

Sources:
51PubMed
See all sources

Articles related to Vein Disease:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
Simultaneous management of renal carcinoma with caval vein thrombosis and double coronary artery disease. (24399123)
2013
2
Crohn's Disease Initially Accompanied by Deep Vein Thrombosis and Ulnar Neuropathy without Metronidazole Exposure. (23560164)
2013
3
A Behcet's Disease Patient with Right Ventricular Thrombus, Pulmonary Artery Aneurysms, and Deep Vein Thrombosis Complicating Recurrent Pulmonary Thromboembolism. (23853733)
2013
4
Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. (23071133)
2013
5
Thrombosis in BehAset's disease: a BehAset's disease patient with complete thrombotic obstruction of IVC and both iliac veins and decreased protein S activity. (22200809)
2013
6
One-shot scleroembolization: a new technique for the treatment of varicose veins disease of lower extremities. Preliminary results. (23934946)
2013
7
Left renal vein division during open surgery of abdominal aortic disease: a propensity score-matched case-control study. (23743276)
2013
8
Risk factors of portal vein thrombosis in Crohn's disease patients. (22456981)
2012
9
Correlation between the hemodynamic gain obtained after operation of primary varicose veins and chronic venous disease classification. (22030826)
2011
10
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
11
Cystic adventitial disease of the common femoral vein. (21549936)
2011
12
A study to compare disease-specific quality of life with clinical anatomical and hemodynamic assessments in patients with varicose veins. (21129895)
2011
13
Patient-reported symptoms are independent of disease severity in patients with primary varicose veins. (21821663)
2011
14
Cystic adventitial disease of the popliteal artery: resection and repair with autologous vein patch. (22263166)
2011
15
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (21690171)
2011
16
The combination of vein grafting and two different types of corporeal plication in complex curvature due to Peyronie's disease. (20389155)
2010
17
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. (20632821)
2010
18
Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease. (19474808)
2009
19
Hansen's disease in an HIV patient complicated by deep vein thrombosis: a rare complication of thalidomide therapy. (19251574)
2009
20
Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thrombophilia. (18388507)
2008
21
The economics of vein disease. (17911565)
2007
22
Septic thrombophlebitis of the superior mesenteric vein and multiple liver abscesses in a patient with Crohn's disease at onset. (17565671)
2007
23
Hodgkin's disease presenting with chylous ascites and cavernous transformation of the portal vein. (17404877)
2007
24
Subcutaneous tissue graft including a scalp artery and a relevant vein for the treatment of cerebral ischemia in childhood moyamoya disease. (17586020)
2007
25
Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein. Implications for bypass graft disease. (16733369)
2006
26
Portal vein thrombosis after splenectomy in pediatric hematologic disease: risk factors, clinical features, and outcome. (17101367)
2006
27
Cystic adventitial disease of the femoral vein presenting as deep vein thrombosis: a case report and review of the literature. (17012010)
2006
28
Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein. (14752408)
2004
29
SIR 2004 Film Panel Case: hepatic actinomycosis from pelvic inflammatory disease causing portal vein thrombosis. (15590787)
2004
30
Ablation of atrial fibrillation in mitral valve disease patients: five year follow-up after percutaneous pulmonary vein isolation and mitral balloon valvuloplasty. (14655306)
2003
31
Pulmonary vein stenosis mimicking chronic lung disease. (12892169)
2003
32
Superior mesenteric vein thrombosis after colectomy for inflammatory bowel disease: a not uncommon cause of postoperative acute abdominal pain. (12792441)
2003
33
Pulmonary vein isolation and left atrial reduction for chronic atrial fibrillation secondary to mitral valve disease. (12735613)
2003
34
Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease. (12504936)
2003
35
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
36
Simple surgical isolation of pulmonary veins for treating secondary atrial fibrillation in mitral valve disease. (11996258)
2002
37
Peyronie's disease: corporoplasty using saphenous vein patch graft. (11834897)
2002
38
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. (11259188)
2001
39
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
40
Peyronie's disease--incision and dorsal vein grafting combined with contralateral plication in straightening the penis. (10452294)
1999
41
PD156707: a potent antagonist of endothelin-1 in human diseased coronary arteries and vein grafts. (9595448)
1998
42
Cystic adventitial disease of the popliteal vein: report of a case. (9161592)
1997
43
Superior mesenteric vein thrombosis associated with anticardiolipin antibody without autoimmune disease. (7847337)
1995
44
Isolated pulmonary vein stenosis in complex congenital heart disease, simulating cor triatriatum by cardiac catheterization and transoesophageal echocardiography. (7744105)
1995
45
Adult Coats' disease in branch retinal vein occlusion. (7818879)
1994
46
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. (1728668)
1992
47
Hepatic vein thrombosis in BehAset's disease. (2194924)
1990
48
Thromboangiitis obliterans (Buerger's disease) in a saphenous vein arterial graft. (3493970)
1987
49
The management of varicose vein disease. (287952)
1979
50
Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)
1945

Genetic Variations for Vein Disease

Expression for genes affiliated with Vein Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Vein Disease

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1serine4510.4PROS1
2Sodium Tetradecyl Sulfate1110.0PROS1, PROC
3warfarin45 50 11 2413.0SERPINC1, PROC
4heparin45 29 11 2412.9MTHFR, PROS1
5monoethylglycinexylidide459.9F5
6certoparin459.8SERPINC1, F2
7polybrene459.7SERPINC1, F2
8hepaplastin459.7SERPINC1, F2
9fibrinopeptide a459.6SERPINC1, F2
10rivaroxaban45 1110.5F2, SERPINC1
11organon459.5SERPINC1, F2
12aprotinin45 1110.4F5, SERPINC1
13batroxobin459.4F2, F5
14vitamin k145 2410.3F2, SERPINC1
15nafamostat mesilate459.3SERPINC1, F5
16kaolin459.3F5, F2
17Drotrecogin alfa119.1F2, F5, PROS1
18eltrombopag50 1110.1F5, SERPINC1
19inogatran459.1SERPINC1, F2, F5
20ecarin459.1F5, SERPINC1, F2
21hirugen459.1F5, SERPINC1, F2
22spectrozyme459.0SERPINC1, F5, F2
23danaparoid459.0SERPINC1, F2, F5
24ancrod459.0SERPINC1, F2, F5
25ximelagatran45 1110.0SERPINC1, F2, F5
26heparinoids459.0F5, F2, SERPINC1
275-methyltetrahydrofolate45 1110.0F5, MTHFR
28fondaparinux459.0F2, F5, SERPINC1
29bivalirudin45 1110.0F5, F2, SERPINC1
30argatroban45 1110.0F2, F5, SERPINC1
31desogestrel45 1110.0F5, SERPINC1, F2
32protamine sulfate459.0F5, SERPINC1, F2
33gestodene45 1110.0F5, F2, SERPINC1
34ristocetin459.0F5, F2, SERPINC1
35levonorgestrel45 60 29 1112.0SERPINC1, F2, F5
36coumarin45 2 50 2412.0F5, F2, SERPINC1
37desmopressin45 60 29 1112.0F5, SERPINC1, F2
38menadione45 11 2411.0MTHFR, PROS1, F2, PROC
39hirudin459.0SERPINC1, F2, F5
40protamine458.9SERPINC1, F2, F5
41dermatan sulfate458.9SERPINC1, F2, F5
42kininogen458.9F5, F2, SERPINC1
43polyethylene glycol458.9F2, F5, SERPINC1
44acenocoumarol45 50 1110.8F5, F2
45gamma-carboxyglutamic acid458.8PROS1, F5, F2, PROC
46phospholipid458.7F2, PROS1, F5, PROC
47homocysteine45 249.4F5, MTHFR, SERPINC1, F2
48aspirin45 50 29 2411.3F5, MTHFR, F2, SERPINC1
49fibrinogen458.0PROC, F5, F2, MTHFR, SERPINC1
50creatinine458.0MTHFR, SERPINC1, F2, F5, PROS1

GO Terms for genes affiliated with Vein Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2PROS1, F5
2Golgi lumenGO:0057969.1F2, PROC, PROS1
3extracellular regionGO:0055767.5F5, PROS1, PROC, F2, SERPINC1

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.6PROS1, F2
2negative regulation of endopeptidase activityGO:0109519.5SERPINC1, PROS1
3peptidyl-glutamic acid carboxylationGO:0171879.3F2, PROC, PROS1
4leukocyte migrationGO:0509009.3F2, PROC, PROS1
5post-translational protein modificationGO:0436879.2F2, PROC, PROS1
6blood circulationGO:0080158.7MTHFR, F5
7platelet activationGO:0301688.6F5, PROS1, F2
8blood coagulationGO:0075968.0F5, PROS1, PROC, F2, SERPINC1

Products for genes affiliated with Vein Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet