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MCID: VND001
MIFTS: 48

Vein Disease

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vein Disease

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MalaCards integrated aliases for Vein Disease:

Name: Vein Disease 12 14
Disorder of Vein 69

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:866
ICD10 32 I82 I87 I87.8
ICD9CM 34 453
SNOMED-CT 64 195435006
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Summaries for Vein Disease

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Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to varicose veins and portal vein thrombosis, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include a vein, skin and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

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Related Diseases for Vein Disease

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Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 varicose veins 32.0 F2 F5 MTHFR SERPINC1
2 portal vein thrombosis 31.1 AFP F2 F5 MTHFR SERPINC1
3 thrombophlebitis 28.8 F2 F5 F8 MTHFR PLAT SERPINC1
4 pulmonary embolism 28.6 ALB F2 F3 F5 MTHFR PLAT
5 thrombosis 28.1 F2 F3 F5 MTHFR PLAT PROC
6 venous insufficiency 11.0
7 paracetamol poisoning 10.6 F2 F5
8 inferior vena cava interruption 10.6 F5 MTHFR
9 antipyrine metabolism 10.6 ALB F2
10 non-a-e hepatitis 10.6 ALB F2
11 mesenteric vascular occlusion 10.6 F2 MTHFR
12 amaurosis fugax 10.6 F5 MTHFR
13 neonatal stroke 10.5 MTHFR PROC
14 pregnancy loss, recurrent 1 10.5 F5 MTHFR
15 livedoid vasculopathy 10.5 F2 F5 MTHFR
16 hemoglobin e disease 10.5 F2 F5
17 cryptogenic cirrhosis 10.5 F2 F5 MTHFR
18 porencephaly 10.5 F2 F5 MTHFR
19 ischemic neuropathy 10.5 F2 MTHFR
20 sticky platelet syndrome 10.5 F5 SERPINC1
21 abdominal tuberculosis 10.5 ALB F2
22 arteritic anterior ischemic optic neuropathy 10.5 F2 F5 MTHFR
23 prothrombin deficiency, congenital 10.5 F2 F5 SERPINC1
24 ischemic colitis 10.4 F2 F5 SERPINC1
25 sneddon syndrome 10.4 F2 F5 SERPINC1
26 cerebral palsy 10.4 F2 F5 MTHFR
27 osteonecrosis 10.4 F2 MTHFR SERPINC1
28 meningococcemia 10.4 F5 PROC SERPINC1
29 acute liver failure 10.4 ALB F2 F5
30 kwashiorkor 10.4 ALB F2
31 hypersplenism 10.4 ALB F2 SERPINC1
32 hepatic tuberculosis 10.4 ALB F2
33 fibrinolytic defect 10.4 PLAT SERPINC1
34 homocystinuria 10.4 F5 MTHFR SERPINC1
35 intermittent claudication 10.4 ALB F2 SERPINC1
36 qualitative platelet defect 10.4 F2 F3
37 intracranial sinus thrombosis 10.4 F3 SERPINC1
38 burns 10.4 ALB SERPINC1
39 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
40 severe pre-eclampsia 10.3 ALB F5 SERPINC1
41 endocarditis 10.3 ALB F2 SERPINC1
42 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG SERPINC1
43 anterior spinal artery syndrome 10.3 F2 PLG SERPINC1
44 spinal cord infarction 10.3 F2 F5 MTHFR SERPINC1
45 conjugate gaze palsy 10.3 F3 PLG
46 sudden sensorineural hearing loss 10.3 F2 F5 MTHFR SERPINC1
47 antithrombin iii deficiency 10.3 F2 F5 MTHFR SERPINC1
48 argentine hemorrhagic fever 10.3 PLAT SERPINC1
49 central retinal vein occlusion 10.3 F2 F5 MTHFR SERPINC1
50 placental abruption 10.3 F2 F5 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease
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Symptoms & Phenotypes for Vein Disease

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UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 ADAM17 EPAS1 EVL AFP ALB F2
2 cardiovascular system MP:0005385 10.35 ADAM17 EPAS1 EVL F2 BLOC1S2 F3
3 mortality/aging MP:0010768 10.32 ADAM17 EPAS1 EVL AFP ALB F2
4 hematopoietic system MP:0005397 10.27 ADAM17 EPAS1 EVL F2 BLOC1S2 F3
5 growth/size/body region MP:0005378 10.25 ADAM17 EPAS1 F2 MTHFR PARVA F3
6 immune system MP:0005387 10.2 ADAM17 EPAS1 EVL F2 F3 PLAT
7 embryo MP:0005380 10.18 BLOC1S2 ADAM17 EPAS1 F2 F3 PARVA
8 nervous system MP:0003631 10.1 ADAM17 EPAS1 EVL F2 BLOC1S2 MTHFR
9 liver/biliary system MP:0005370 10.06 EPAS1 AFP ALB BLOC1S2 F5 PLG
10 integument MP:0010771 10.03 ADAM17 F2 MTHFR F3 PLAT F5
11 muscle MP:0005369 9.92 ADAM17 EPAS1 ALB F3 PARVA PLAT
12 reproductive system MP:0005389 9.76 ADAM17 AFP F2 MTHFR PLAT F8
13 respiratory system MP:0005388 9.5 ADAM17 EPAS1 F2 F3 PLAT PLG
14 vision/eye MP:0005391 9.23 BLOC1S2 ADAM17 EPAS1 MTHFR F3 PLAT
Sources

Drugs & Therapeutics for Vein Disease

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Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Rivaroxaban Approved Phase 4 366789-02-8
4
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4 139-88-8, 1191-50-0 5248 14492
5 Racepinephrine Approved Phase 4 329-65-7
6
Polidocanol Approved Phase 4 9002-92-0
7 Anticoagulants Phase 4,Phase 3
8 Aminaftone Phase 4
9 Coagulants Phase 4,Phase 3
10 Hemostatics Phase 4,Phase 3
11 Pharmaceutical Solutions Phase 4
12 Anti-Inflammatory Agents Phase 4
13
protease inhibitors Phase 4,Phase 3
14 Respiratory System Agents Phase 4
15 Central Nervous System Depressants Phase 4
16 Adrenergic Agents Phase 4
17 Serine Proteinase Inhibitors Phase 4
18 Adrenergic Agonists Phase 4
19 Adrenergic alpha-Agonists Phase 4
20 Mydriatics Phase 4
21 Sodium Channel Blockers Phase 4
22 Adrenergic beta-Agonists Phase 4
23 Neurotransmitter Agents Phase 4
24 HIV Protease Inhibitors Phase 4,Phase 3
25 Vasoconstrictor Agents Phase 4
26 Anesthetics Phase 4
27 Anesthetics, Local Phase 4
28 Diuretics, Potassium Sparing Phase 4
29 Peripheral Nervous System Agents Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Anti-Asthmatic Agents Phase 4
32 Epinephryl borate Phase 4
33 Factor Xa Inhibitors Phase 4
34 Autonomic Agents Phase 4
35 Bronchodilator Agents Phase 4
36 Antithrombin III Phase 4
37 Antithrombins Phase 4
38 serine Nutraceutical Phase 4
39
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
40 Nadroparin Approved, Investigational Phase 3 9041-08-1
41
Dalteparin Approved Phase 3 9005-49-6
42 calcium heparin Phase 3
43 Fibrinolytic Agents Phase 3
44 Heparin, Low-Molecular-Weight Phase 3
45 Calcium, Dietary Phase 3
46 Mitogens Phase 3
47 Angiogenesis Inducing Agents Phase 3
48 Angiogenesis Modulating Agents Phase 3
49 Anti-HIV Agents Phase 3
50 Anti-Infective Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 53)

# Name Status NCT ID Phase Drugs
1 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
2 Efficacy on Pain Following a Procedure for Injecting Sclerotherapeutic Foam Into the Great Saphenous Vein Completed NCT01368159 Phase 4
3 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
4 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
5 Rivaroxaban With Diosmine in Long-term Treatment of DVT Recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
6 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
7 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
8 Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Withdrawn NCT02988063 Phase 4 Polidocanol Endovenous Microfoam (PEM)
9 Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT) Unknown status NCT00421538 Phase 3 nadroparine calcium;Placebo
10 Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs Completed NCT01532882 Phase 3 Diosmin;Placebo
11 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
12 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
13 Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
14 Calcium Dobesilate for Chronic Venous Wounds Suspended NCT00979836 Phase 3 Calcium Dobesilate
15 Great Saphenous Vein Electrocoagulation Unknown status NCT02139085 Phase 2
16 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
17 Treatment of Claudication With a Peristaltic Pulse Pneumatic Device Unknown status NCT01007604 Phase 2
18 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
19 Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Completed NCT01509599 Phase 1, Phase 2
20 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
21 EXPLORATORY ASSESSMENT OF THE EFFECTS OF CYCLO 3 ® FORT (Ruscus Extract, Hesperidin Methyl Chalcone, Ascorbic Acid) OR MICRONISED PURIFIED FLAVONOID FRACTION ON VASCULAR PARAMETERS AND BIOMARKERS IN WOMEN SUFFERING FROM CHRONIC VENOUS DISEASE (CEAP C2 OR Withdrawn NCT02907320 Phase 2 CYCLO 3 ® FORT;MPFF;placebo CYCLO 3 ® FORT;placebo MPFF
22 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
23 Evaluating the Occurence of New and Progression of Existing Peripheral Venous Disease in Leg Veins Completed NCT00508079
24 Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs Completed NCT02731222
25 Prevalence of MTHFR Polymorphisms in Venous Disease Completed NCT01993914
26 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
27 FOAM-study, Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins Completed NCT01103258
28 Epidemiology of Venous Disease Completed NCT00005392
29 Venous Insufficiency and Neuromuscular Stimulation Completed NCT02137499
30 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568
31 Copper Impact on Venous Insufficiency and Lipodermatosclerosis Completed NCT03283800
32 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985
33 Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome Completed NCT00395265
34 Non-Invasive Management of Chronic Venous Insufficiency Completed NCT00950378
35 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482
36 Ongoing Registry of Treatment of Chronic Venous Diseases Recruiting NCT03035747
37 Elastic Compression in Chronic Venous Disease Recruiting NCT02641600
38 New Genetic Mutations in Thromboembolic Venous Disease Idiopathic. Study "FIT GENETIQUE". Recruiting NCT02841085
39 Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1) Recruiting NCT02662127
40 Haemorrhages and Thromboembolic Venous Disease of the Postpartum Recruiting NCT02443610
41 Treatment of Insufficient Superficial and Perforating Veins of the Lower Limb Using HIFU Recruiting NCT03304834
42 Retinal Thrombosis and Atherosclerosis Recruiting NCT02257333
43 Registry of Patient With Antithrombotic Agents Admitted to an Emergency Department Recruiting NCT02706080
44 Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure Recruiting NCT03206372
45 Bern Venous Stent Registry Recruiting NCT02433054
46 Sinai Vein Stent Registry Recruiting NCT02600936
47 FireFly Vein Finder: Venepuncture Made Easy Active, not recruiting NCT03202238
48 Ecchymosis and Coldness in Patients With Varicose Vein Not yet recruiting NCT03384355
49 Vein Fitness System vs Compressive Therapy for Venous Ulcers: a Bayesian Adaptive Trial Not yet recruiting NCT03127904
50 Effect of VarIthena on Wound Healing in VLU Not yet recruiting NCT03257254 Varithena

Search NIH Clinical Center for Vein Disease

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Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

18
A Vein

MalaCards organs/tissues related to Vein Disease:

38
Skin, Bone
Sources

Publications for Vein Disease

About this section

Articles related to Vein Disease:

(show all 41)
# Title Authors Year
1
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. ( 28431588 )
2017
2
Early clinical experience using telemedicine for the management of patients with varicose vein disease. ( 28969485 )
2017
3
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease - ETAV Consensus Meeting 2012. ( 24534341 )
2014
4
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. ( 25007903 )
2014
5
Cost analysis of endovenous catheter ablation versus surgical stripping for treatment of superficial venous insufficiency and varicose vein disease. ( 26992979 )
2014
6
One-shot scleroembolization: a new technique for the treatment of varicose veins disease of lower extremities. Preliminary results. ( 23934946 )
2013
7
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. ( 24126200 )
2013
8
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. ( 22955688 )
2013
9
A review of familial, genetic, and congenital aspects of primary varicose vein disease. ( 22896013 )
2012
10
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. ( 23997567 )
2012
11
The significance of upper arm cephalic vein disease in vascular access creation. ( 23020965 )
2012
12
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 20881312 )
2011
13
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 21690171 )
2011
14
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. ( 21080204 )
2011
15
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. ( 21262580 )
2011
16
Minimally invasive vein surgery: latest options for vein disease. ( 20506452 )
2010
17
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. ( 20632821 )
2010
18
Chronic venous insufficiency: current management of varicose vein disease. ( 20336886 )
2010
19
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. ( 20227536 )
2010
20
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. ( 18944196 )
2008
21
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. ( 17985316 )
2007
22
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. ( 17294343 )
2007
23
The economics of vein disease. ( 17911565 )
2007
24
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). ( 18004259 )
2007
25
Selection of saphenous vein conduit in varicose vein disease. ( 16564256 )
2006
26
The histopathology of varicose vein disease. ( 17067976 )
2006
27
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). ( 15183051 )
2004
28
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. ( 12388823 )
2002
29
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. ( 11907341 )
2002
30
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. ( 11259188 )
2001
31
A unique virus complex causes Ageratum yellow vein disease. ( 10841581 )
2000
32
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. ( 10544139 )
1999
33
Symptomatology of vein disease. ( 7728483 )
1995
34
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. ( 1728668 )
1992
35
The management of varicose vein disease. ( 287952 )
1979
36
The modern treatment of varicose vein disease. ( 4520459 )
1973
37
Phlebography in varicose vein disease. ( 5014478 )
1972
38
Mesenteric vein disease. ( 13740328 )
1961
39
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. ( 13843232 )
1960
40
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18111784 )
1949
41
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18877800 )
1948
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Variations for Vein Disease

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Expression for Vein Disease

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Search GEO for disease gene expression data for Vein Disease.
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Pathways for Vein Disease

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Pathways related to Vein Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 62
Show member pathways
 12.93 ALB F2 F3 F5 F8 PLAT
2
Collagen chain trimerization 62
Show member pathways
 12.52 F2 F3 F5 F8 PROC PROS1
3
Selenium Micronutrient Network 1
Show member pathways
 12.1 ALB F2 MTHFR PLAT PLG
4
Formation of Fibrin Clot (Clotting Cascade) 62
Show member pathways
 11.81 F2 F3 F5 F8 PLAT PLG
5
Adhesion 4
11.75 F3 PARVA PLG
6
Gamma carboxylation, hypusine formation and arylsulfatase activation 62
Show member pathways
 11.69 F2 PROC PROS1
7
Complement and coagulation cascades 36 1
11.42 F2 F3 F5 F8 PLAT PLG
8
FOXA2 and FOXA3 transcription factor networks 1
11.25 AFP ALB F2
9
A-beta Pathways: Plaque Formation and APP Metabolism 61
10.94 ADAM17 PLAT PLG
10
Warfarin Pathway, Pharmacodynamics 57
10.67 F2 PROC PROS1
11
Dissolution of Fibrin Clot 62
10.57 PLAT PLG
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GO Terms for Vein Disease

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Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.72 ALB F2 PLG PROS1 SERPINC1
2 platelet alpha granule lumen GO:0031093 9.55 ALB F5 F8 PLG PROS1
3 Golgi lumen GO:0005796 9.54 F2 PROC PROS1
4 endoplasmic reticulum lumen GO:0005788 9.5 AFP ALB F2 F5 F8 PROC
5 extracellular space GO:0005615 9.4 AFP ALB F2 F3 F5 F8
6 extracellular region GO:0005576 10.03 AFP ALB F2 F3 F5 F8

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.91 AFP ALB EPAS1 F5 PROC SERPINC1
2 ER to Golgi vesicle-mediated transport GO:0006888 9.8 F2 F5 F8 PROC PROS1
3 response to hypoxia GO:0001666 9.78 ADAM17 EPAS1 MTHFR PLAT
4 platelet degranulation GO:0002576 9.72 ALB F5 F8 PLG PROS1
5 cellular protein metabolic process GO:0044267 9.7 AFP ALB F2 F5 PLG PROC
6 signal peptide processing GO:0006465 9.63 F2 PROC PROS1
7 blood coagulation GO:0007596 9.61 F2 F3 F5 F8 PLAT PLG
8 fibrinolysis GO:0042730 9.56 F2 PLAT PLG PROS1
9 peptidyl-glutamic acid carboxylation GO:0017187 9.54 F2 PROC PROS1
10 blood coagulation, intrinsic pathway GO:0007597 9.52 F2 F8
11 negative regulation of blood coagulation GO:0030195 9.51 PROC PROS1
12 negative regulation of fibrinolysis GO:0051918 9.49 F2 PLG
13 hemostasis GO:0007599 9.23 F2 F3 F5 F8 PLG PROC

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.65 ADAM17 F2 PLAT PLG PROC
2 copper ion binding GO:0005507 9.33 ALB F5 F8
3 serine-type peptidase activity GO:0008236 9.26 F2 PLAT PLG PROC
4 serine-type endopeptidase activity GO:0004252 9.02 F2 F3 PLAT PLG PROC
Sources

Sources for Vein Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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