MCID: VND001
MIFTS: 48

Vein Disease malady

Cardiovascular diseases category

Summaries for Vein Disease

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32MalaCards
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MalaCards: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and vascular disease. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Cell surface interactions at the vascular wall and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds serine and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and endothelial, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Vein Disease

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

vein disease 8
disorder of vein 60


External Ids:

Disease Ontology8 DOID:866
ICD9CM27 453
SNOMED-CT56 195435006
ICD1025 I87, I87.8

Related Diseases for Vein Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism29.9F5, MTHFR, PROS1, F2, SERPINC1
2vascular disease29.7SERPINC1, MTHFR, F5
3hypertension29.7F2, PROS1, MTHFR, F5
4thrombophlebitis10.0
5hepatic vein thrombosis10.0PROS1
6varicose veins10.0F2
7purpura10.0SERPINC1
8sneddon syndrome10.0SERPINC1
9cholestasis10.0F2
10kidney cancer10.0EPAS1
11hepatitis10.0F2
12acute myocardial infarction10.0SERPINC1
13hepatitis a10.0F2
14respiratory failure10.0SERPINC1
15vitamin k deficiency hemorrhagic disease10.0F2
16cerebrovascular disease10.0MTHFR
17rheumatoid arthritis10.0MTHFR
18viral hepatitis10.0F2
19coronary thrombosis10.0SERPINC1
20prostatitis10.0PROS1
21neural tube defects10.0MTHFR
22acute leukemia10.0MTHFR
23nephrotic syndrome10.0SERPINC1
24patent foramen ovale10.0F5
25ovarian hyperstimulation syndrome10.0F5
26branch retinal artery occlusion10.0F5
27retinal vascular occlusion10.0F5
28leukemia10.0MTHFR
29factor xii deficiency10.0F5
30factor viii deficiency10.0F5
31migraine10.0MTHFR
32vasculitis10.0F2, PROS1
33hepatitis c10.0F2
34thrombocytosis10.0SERPINC1, F2
35deficiency anemia10.0F2, EPAS1
36eclampsia10.0SERPINC1, MTHFR
37coronary heart disease10.0MTHFR, SERPINC1
38atherosclerosis10.0SERPINC1, MTHFR
39colorectal cancer10.0MTHFR, PROS1
40hepatocellular carcinoma10.0EPAS1, F2
41meningococcemia10.0F5, SERPINC1
42stroke, ischemic10.0F5, F2
43postphlebitic syndrome10.0F5, SERPINC1
44legg-calve-perthes disease10.0F5, SERPINC1
45factor x deficiency10.0F5, F2
46central retinal vein occlusion10.0MTHFR, F5
47factor v deficiency10.0F5, F2
48homocysteinemia10.0MTHFR, F5
49liver cirrhosis10.0PROS1, F2, SERPINC1
50factor xi deficiency10.0F5, F2

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Clinical Features for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Vein Disease

Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Search CenterWatch for Vein Disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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32MalaCards
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MalaCards organs/tissues related to Vein Disease:

32
Liver, Heart, Endothelial, Smooth muscle, Bone, Lung, Thyroid, Brain, Bone marrow

Animal Models for Vein Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Vein Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.0F2
2MP:00053978.2SERPINC1, F2, EPAS1, PROC, PROS1
3MP:00053707.8F5, PROS1, PROC, EPAS1, SERPINC1
4MP:00053807.4F5, PROS1, EPAS1, F2, SERPINC1
5MP:00036316.9SERPINC1, F5, MTHFR, PROS1, PROC, EPAS1
6MP:00053766.9F5, MTHFR, PROS1, PROC, EPAS1, F2
7MP:00107686.7F5, MTHFR, PROS1, PROC, EPAS1, F2

Publications for Vein Disease

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Sources:
50PubMed
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Articles related to Vein Disease:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Re. 'Left Renal Vein Division During Open Surgery of Abdominal Aortic Disease: A Propensity Score-matched Case-control Study'. (24215728)
2014
2
Intra-jugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice. (24390280)
2014
3
Simultaneous management of renal carcinoma with caval vein thrombosis and double coronary artery disease. (24399123)
2013
4
Cystic adventitial disease of the common femoral vein: a case report and review of the literature. (23873672)
2013
5
Rheological properties of young and aged erythrocytes in chronic venous disease patients with varicose veins. (23594503)
2013
6
Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. (23071133)
2013
7
Impact of Extracardiac Vascular Disease on Vein Graft Failure and Outcomes After Coronary Artery Bypass Surgery. (24360877)
2013
8
Minimally invasive, endovenous laser treatment of varicose veins in patients with von Willebrand disease. (24364473)
2013
9
Thrombosis in BehAset's disease: a BehAset's disease patient with complete thrombotic obstruction of IVC and both iliac veins and decreased protein S activity. (22200809)
2013
10
Adventitial cystic disease of the common femoral vein presenting as deep vein thrombosis. (23978427)
2013
11
Left renal vein division during open surgery of abdominal aortic disease: a propensity score-matched case-control study. (23743276)
2013
12
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)
2013
13
Mid- and long-term results of the treatment of infrainguinal arterial occlusive disease with precuffed expanded polytetrafluoroethylene grafts compared with vein grafts. (22998787)
2013
14
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. (22944580)
2012
15
Bilateral disease and early age at presentation are associated with shorter survival in patients with congenital heart disease and intraluminal pulmonary vein stenosis. (22469299)
2012
16
Obstruction of the superior vena cava and stenosis of the right brachiocephalic vein in a patient with Adamantiades-Behcet's disease. (24391429)
2011
17
Patient-reported symptoms are independent of disease severity in patients with primary varicose veins. (21821663)
2011
18
Midterm results of autologous saphenous vein and ePTFE pre-cuffed bypass surgery in peripheral arterial occlusive disease. (21757494)
2011
19
Survival among children with portal vein thrombosis and end-stage liver disease. (19413719)
2010
20
Macular ischaemia after intravitreal bevacizumab injection in patients with central retinal vein occlusion and a history of diabetes and vascular disease. (20215378)
2010
21
Pre-existent portal vein thrombosis in liver transplantation: influence of pre-operative disease severity. (19236435)
2010
22
Thrombosis of temporal artery and renal vein in Kimura-disease-related nephrotic syndrome. (18066701)
2009
23
Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with BehAset disease involving superficial vein thrombophlebitis. (19221262)
2009
24
Portal vein thrombosis in adult-onset Still's disease: a case report and literature review. (19306000)
2009
25
Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease. (19047778)
2009
26
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
27
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)
2008
28
Disclosure of a financial relationship relating to "surgery for paroxysmal atrial fibrillation in the setting of mitral valve disease: a role for pulmonary vein isolation. Ann Thorac Surg 2006;81:19-28". (16488760)
2006
29
Reversal of left atrial-pulmonary vein remodeling in hypertensive heart disease. (16903973)
2006
30
Nonischemic central retinal vein occlusion associated with celiac disease. (15704767)
2005
31
Hypertension and hypertensive heart disease are associated with increased ostial pulmonary vein diameter. (15673377)
2005
32
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)
2004
33
Isolation of the pulmonary veins in patients with permanent atrial fibrillation secondary to mitral valve disease. (15320554)
2004
34
Portal vein thrombosis following laparoscopic surgery in a patient with sickle cell disease. (15765550)
2003
35
Thrombophilic genotypes, natural anticoagulants, and plasma homocysteine in myeloproliferative disorders: relationship with splanchnic vein thrombosis and arterial disease. (12555209)
2003
36
Pulmonary vein stenosis mimicking chronic lung disease. (12892169)
2003
37
Gene therapy for all aspects of vein-graft disease. (12643467)
2002
38
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
39
Peyronie's disease: corporoplasty using saphenous vein patch graft. (11834897)
2002
40
Diameter comparison of saphenous vein bypasses for popliteal aneurysm versus peripheral arterial occlusive disease in matched subjects. (16222384)
2001
41
Portal vein and bone involvement in disseminated cat-scratch disease: report of 2 cases. (11017839)
2000
42
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)
1999
43
PD156707: a potent antagonist of endothelin-1 in human diseased coronary arteries and vein grafts. (9595448)
1998
44
The presence of higher levels of thyroglobulin, but not thyroid autoantibodies, in the thyroid vein in Graves' disease. (7911812)
1994
45
Recurrence of cystic adventitial disease in an interposed vein graft. (8079189)
1994
46
Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. (8272217)
1993
47
Cytokeratins 8 and 18 in smooth muscle cells. Detection in human coronary artery, peripheral vascular, and vein graft disease and in transplantation-associated arteriosclerosis. (7692956)
1993
48
The effect of caffeine on renal vein renin concentration in patients with renal arterial disease. (1815652)
1991
49
Veno-occlusive disease and primary hepatic vein thrombosis in Israeli Arabs. (7263190)
1981
50
Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)
1945

Genetic Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Vein Disease

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1serine4410.4PROS1
2Sodium Tetradecyl Sulfate1110.0PROC, PROS1
3warfarin44 49 11 2413.0SERPINC1, PROC
4monoethylglycinexylidide449.9F5
5heparin44 28 11 2412.9MTHFR, PROS1
6certoparin449.8SERPINC1, F2
7polybrene449.7SERPINC1, F2
8fibrinopeptide a449.7F2, SERPINC1
9hepaplastin449.6F2, SERPINC1
10organon449.5F2, SERPINC1
11rivaroxaban44 1110.4F2, SERPINC1
12aprotinin44 1110.4SERPINC1, F5
13batroxobin449.4F5, F2
14vitamin k144 2410.3F2, SERPINC1
15nafamostat mesilate449.3F5, SERPINC1
16kaolin449.3F5, F2
17eltrombopag49 1110.2F5, SERPINC1
18Drotrecogin alfa119.1F5, PROS1, F2
19acenocoumarol44 49 1111.1F2, F5
20inogatran449.1SERPINC1, F2, F5
21hirugen449.1SERPINC1, F2, F5
22ecarin449.1SERPINC1, F2, F5
23spectrozyme449.0F5, F2, SERPINC1
24danaparoid449.0SERPINC1, F2, F5
25ancrod449.0F5, F2, SERPINC1
26ximelagatran44 1110.0F5, F2, SERPINC1
27heparinoids449.0F5, F2, SERPINC1
28fondaparinux449.0SERPINC1, F2, F5
29bivalirudin44 1110.0F5, F2, SERPINC1
30argatroban44 1110.0F5, F2, SERPINC1
31desogestrel44 1110.0F5, F2, SERPINC1
32protamine sulfate449.0F5, F2, SERPINC1
33gestodene44 1110.0SERPINC1, F2, F5
34ristocetin449.0SERPINC1, F2, F5
35levonorgestrel44 59 28 1112.0SERPINC1, F2, F5
36coumarin44 2 49 2412.0F5, F2, SERPINC1
37desmopressin44 59 28 1112.0F5, F2, SERPINC1
38menadione44 11 2411.0F2, PROC, PROS1, MTHFR
39hirudin449.0F5, F2, SERPINC1
40protamine448.9SERPINC1, F2, F5
41dermatan sulfate448.9F5, F2, SERPINC1
42kininogen448.9SERPINC1, F2, F5
43polyethylene glycol448.9F5, F2, SERPINC1
44gamma-carboxyglutamic acid448.8F5, PROS1, PROC, F2
455-methyltetrahydrofolate44 119.7MTHFR, F5
46phospholipid448.7F5, PROS1, PROC, F2
47homocysteine44 249.4F5, MTHFR, F2, SERPINC1
48aspirin44 49 28 2411.3F5, MTHFR, F2, SERPINC1
49fibrinogen448.0F5, MTHFR, PROC, F2, SERPINC1
50creatinine448.0F5, MTHFR, PROS1, F2, SERPINC1

GO Terms for genes affiliated with Vein Disease

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16Gene Ontology
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Cellular components related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2PROS1, F5
2Golgi lumenGO:0057969.1F2, PROC, PROS1
3extracellular regionGO:0055767.5F5, PROS1, PROC, F2, SERPINC1

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.6PROS1, F2
2negative regulation of endopeptidase activityGO:0109519.5SERPINC1, PROS1
3peptidyl-glutamic acid carboxylationGO:0171879.3F2, PROC, PROS1
4leukocyte migrationGO:0509009.3F2, PROC, PROS1
5post-translational protein modificationGO:0436879.2F2, PROC, PROS1
6blood circulationGO:0080158.7MTHFR, F5
7platelet activationGO:0301688.6F5, PROS1, F2
8blood coagulationGO:0075968.0F5, PROS1, PROC, F2, SERPINC1

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet