MCID: VND001
MIFTS: 44

Vein Disease malady

Cardiovascular diseases category
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Summaries for Vein Disease

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Disease Ontology:8 A vascular disease that is located in a vein.

MalaCards based summary: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and portal vein thrombosis. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Immune response IL 23 signaling pathway and Selenium Pathway. The compounds 5-methyltetrahydrofolate and inogatran have been mentioned in the context of this disorder. Affiliated tissues include a vein, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Vein Disease

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Vein Disease, Aliases & Descriptions:

Name: Vein Disease 8
 
Disorder of Vein 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:866
ICD9CM27 453
SNOMED-CT57 195435006
ICD1025 I87, I87.8

Related Diseases for Vein Disease

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Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism29.4F2, MTHFR, F5, PROS1
2portal vein thrombosis29.1F5, MTHFR, F2, PROS1
3hypertension29.1MTHFR, F5, PROS1, F2
4hepatic vein thrombosis10.4PROS1
5varicose veins10.4
6eclampsia10.3MTHFR
7hemophilia b10.3F2
8branch retinal artery occlusion10.3F5
9factor xii deficiency10.3F5
10meningococcemia10.3F5
11sagittal sinus thrombosis10.1F5, PROS1
12homocysteinemia10.1F5, MTHFR
13central retinal vein occlusion10.1F5, MTHFR
14placental abruption10.1MTHFR, F5
15retinal vein occlusion10.0F5, MTHFR
16intracranial thrombosis10.0F5, MTHFR
17vasculitis10.0F2, PROS1
18hellp syndrome10.0F5, MTHFR
19prothrombin deficiency10.0F2, F5
20factor x deficiency10.0F2, F5
21factor v deficiency10.0F2, F5
22factor xi deficiency10.0F2, F5
23liver cirrhosis10.0PROS1, F2
24dysfibrinogenemia10.0F5, F2
25hemorrhagic disease10.0F2, F5
26scott syndrome10.0F2, F5
27von willebrand's disease10.0F2, F5
28factor vii deficiency10.0F5, F2
29venous insufficiency10.0
30factor viii deficiency10.0F2, F5
31homocystinuria10.0F5, MTHFR
32afibrinogenemia10.0F5, F2
33stroke, ischemic9.9MTHFR, F5
34congenital heart disease9.9F2, MTHFR
35disseminated intravascular coagulation9.8F5, PROC, F2
36galactosemia9.8F2, F5
37lupus erythematosus9.8F2, F5, PROS1
38chronic venous insufficiency9.8
39thrombophlebitis9.8
40hypoxia9.8
41pregnancy loss9.8F2, F5, MTHFR
42sepsis9.8F5, PROC, F2
43pre-eclampsia9.8MTHFR, F2, F5
44thrombocytopenia9.7F2, F5
45cerebrovascular disease9.7F5, MTHFR, F2
46thromboembolism9.6MTHFR, F5, PROC, F2
47blood protein disease9.6PROS1, F2, MTHFR, F5
48antithrombin iii deficiency9.6F2, PROS1, MTHFR, F5
49protein s deficiency9.6F2, PROS1, F5, MTHFR
50antiphospholipid syndrome9.6F2, PROS1, MTHFR, F5

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Symptoms for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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FMA organs/tissues related to Vein Disease:

14
A vein

Animal Models for Vein Disease or affiliated genes

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MGI Mouse Phenotypes related to Vein Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PROS1, PROC, EPAS1, F2
2MP:00053708.3F5, PROS1, PROC, EPAS1
3MP:00107718.0F2, PROS1, MTHFR, F5
4MP:00053857.8F2, EPAS1, PROC, PROS1, F5
5MP:00053807.8F2, EPAS1, PROS1, F5
6MP:00053787.6F2, EPAS1, PROC, MTHFR, F5
7MP:00036317.3F5, MTHFR, PROS1, PROC, EPAS1, F2
8MP:00053767.3F2, EPAS1, PROC, PROS1, MTHFR, F5
9MP:00107687.3F2, EPAS1, PROC, PROS1, MTHFR, F5

Publications for Vein Disease

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Articles related to Vein Disease:

(show all 36)
idTitleAuthorsYear
1
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease - ETAV Consensus Meeting 2012. (24534341)
2014
2
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. (25007903)
2014
3
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)
2013
4
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. (22955688)
2013
5
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. (23997567)
2012
6
The significance of upper arm cephalic vein disease in vascular access creation. (23020965)
2012
7
A review of familial, genetic, and congenital aspects of primary varicose vein disease. (22896013)
2012
8
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
9
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. (21262580)
2011
10
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. (21080204)
2011
11
Chronic venous insufficiency: current management of varicose vein disease. (20336886)
2010
12
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. (20227536)
2010
13
Minimally invasive vein surgery: latest options for vein disease. (20506452)
2010
14
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. (20632821)
2010
15
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)
2008
16
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. (17294343)
2007
17
The economics of vein disease. (17911565)
2007
18
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). (18004259)
2007
19
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. (17985316)
2007
20
The histopathology of varicose vein disease. (17067976)
2006
21
Selection of saphenous vein conduit in varicose vein disease. (16564256)
2006
22
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)
2004
23
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
24
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. (12388823)
2002
25
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. (11259188)
2001
26
A unique virus complex causes Ageratum yellow vein disease. (10841581)
2000
27
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)
1999
28
Symptomatology of vein disease. (7728483)
1995
29
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. (1728668)
1992
30
The management of varicose vein disease. (287952)
1979
31
The modern treatment of varicose vein disease. (4520459)
1973
32
Phlebography in varicose vein disease. (5014478)
1972
33
Mesenteric vein disease. (13740328)
1961
34
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. (13843232)
1960
35
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18111784)
1949
36
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18877800)
1948

Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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Expression patterns in normal tissues for genes affiliated with Vein Disease

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Pathways for genes affiliated with Vein Disease

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Pathways related to Vein Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3EPAS1, F2
2
Show member pathways
thioredoxin pathway37
9.3MTHFR, F2
3
Show member pathways
9.2PROS1, F5
4
Show member pathways
9.0PROS1, PROC, F2
5
Show member pathways
9.0F2, PROC, PROS1
6
Show member pathways
9.0PROS1, PROC, F2
7
Show member pathways
8.2F5, PROS1, PROC, F2
8
Show member pathways
8.2F5, PROS1, PROC, F2
9
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.2F2, PROC, PROS1, F5
10
Show member pathways
8.2F2, PROC, PROS1, F5

Compounds for genes affiliated with Vein Disease

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Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
15-methyltetrahydrofolate44 1110.5MTHFR, F5
2inogatran449.5F5, F2
3cystathionine449.5F5, MTHFR
4ecarin449.5F2, F5
5hirugen449.5F2, F5
6spectrozyme449.5F2, F5
7danaparoid449.5F2, F5
8monoethylglycinexylidide449.4F2, F5
9batroxobin449.4F2, F5
10kaolin449.4F2, F5
11ximelagatran44 1110.4F2, F5
12ancrod449.4F2, F5
13heparinoids449.4F5, F2
14fondaparinux449.4F2, F5
15acenocoumarol44 50 1111.4F2, F5
16bivalirudin44 1110.4F2, F5
17coumarins449.4F2, F5
18desogestrel44 1110.4F2, F5
19argatroban44 1110.4F2, F5
20protamine sulfate449.4F5, F2
21gestodene44 1110.4F2, F5
22vitamin b6449.4MTHFR, F5
23ofloxacin44 2 1111.4F2, F5
24penicillin449.4F5, F2
25antipyrine44 1110.3F5, F2
26ristocetin449.3F5, F2
27cyproteroneacetate449.3F2, F5
28levonorgestrel44 61 28 1112.3F5, F2
29coumarin44 2 50 2412.3F5, F2
30desmopressin44 61 28 1112.3F5, F2
31cardiolipin44 1110.3F2, F5
32hirudin449.2F5, F2
33phosphatidylethanolamine44 1110.2F5, F2
34protamine449.2F2, F5
35dermatan sulfate449.1F5, F2
36kininogen449.0F2, F5
37acetaminophen44 2 50 24 1113.0F5, F2
38metformin44 50 1111.0F5, MTHFR
39homocysteine44 249.9F5, MTHFR, F2
40menadione44 24 1110.9F2, PROC, PROS1, MTHFR
41aspirin44 50 28 2411.9F5, MTHFR, F2
42vitamin b12448.8F5, MTHFR
43gamma-carboxyglutamic acid448.6F5, PROS1, PROC, F2
44phospholipid448.6F2, PROC, PROS1, F5
45aspartate448.6F5, MTHFR, F2
46warfarin44 50 24 1111.5F2, PROC, MTHFR, F5
47fibrinogen448.5F5, MTHFR, PROC, F2
48creatinine448.5F5, MTHFR, PROS1, F2
49heparin44 28 24 1111.1F2, PROC, PROS1, MTHFR, F5
50serine448.1F2, PROC, PROS1, MTHFR, F5

GO Terms for genes affiliated with Vein Disease

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Cellular components related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4PROS1, F2
2platelet alpha granule lumenGO:0310939.1PROS1, F5
3Golgi lumenGO:0057969.0PROC, F2, PROS1
4extracellular regionGO:0055767.9F5, F2, PROC, PROS1

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.4PROS1, F2
2peptidyl-glutamic acid carboxylationGO:0171879.2PROS1, PROC, F2
3platelet degranulationGO:0025769.2F5, PROS1
4leukocyte migrationGO:0509009.2F2, PROC, PROS1
5proteolysisGO:0065089.1PROS1, PROC, F2
6post-translational protein modificationGO:0436879.1F2, PROC, PROS1
7blood circulationGO:0080159.0MTHFR, F5
8cellular protein metabolic processGO:0442678.7PROS1, PROC, F2
9platelet activationGO:0301688.6F5, PROS1, F2
10blood coagulationGO:0075968.4F5, PROS1, PROC, F2

Molecular functions related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055099.0PROS1, PROC, F2
2serine-type endopeptidase activityGO:0042528.3F5, PROC, F2

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Vein Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet