MCID: VND001
MIFTS: 44

Vein Disease malady

Cardiovascular diseases category
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Summaries for Vein Disease

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A vascular disease that is located in a vein.

MalaCards: Vein Disease, also known as disorder of vein, is related to pulmonary embolism and portal vein thrombosis. An important gene associated with Vein Disease is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Immune response IL 23 signaling pathway and Selenium Pathway. The compounds 5-methyltetrahydrofolate and inogatran have been mentioned in the context of this disorder. Affiliated tissues include a vein, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Vein Disease

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Sources:
8Disease Ontology, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

vein disease 8
disorder of vein 62


External Ids:

Disease Ontology8 DOID:866
ICD9CM27 453
SNOMED-CT58 195435006
ICD1025 I87, I87.8

Related Diseases for Vein Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vein Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism29.8F2, MTHFR, F5, PROS1
2portal vein thrombosis29.6F5, MTHFR, F2, PROS1
3hypertension29.6MTHFR, F5, PROS1, F2
4varicose veins10.4
5hepatic vein thrombosis10.1PROS1
6eclampsia10.1MTHFR
7hemophilia b10.1F2
8branch retinal artery occlusion10.1F5
9factor xii deficiency10.1F5
10meningococcemia10.1F5
11purpura fulminans10.0F5, PROC
12sagittal sinus thrombosis10.0F5, PROS1
13homocysteinemia10.0F5, MTHFR
14central retinal vein occlusion10.0F5, MTHFR
15placental abruption10.0MTHFR, F5
16retinal vein occlusion10.0F5, MTHFR
17intracranial thrombosis10.0F5, MTHFR
18vasculitis10.0F2, PROS1
19hellp syndrome10.0F5, MTHFR
20prothrombin deficiency10.0F2, F5
21factor x deficiency10.0F2, F5
22factor v deficiency10.0F2, F5
23factor xi deficiency10.0F2, F5
24liver cirrhosis10.0PROS1, F2
25dysfibrinogenemia10.0F5, F2
26hemorrhagic disease10.0F2, F5
27scott syndrome10.0F2, F5
28von willebrand's disease10.0F2, F5
29factor vii deficiency10.0F5, F2
30factor viii deficiency10.0F2, F5
31homocystinuria10.0F5, MTHFR
32afibrinogenemia10.0F5, F2
33stroke, ischemic10.0MTHFR, F5
34congenital heart disease10.0F2, MTHFR
35disseminated intravascular coagulation10.0F5, PROC, F2
36galactosemia10.0F2, F5
37lupus erythematosus10.0F2, F5, PROS1
38thrombophlebitis10.0
39venous insufficiency10.0
40pregnancy loss9.9F2, F5, MTHFR
41sepsis9.9F5, PROC, F2
42pre-eclampsia9.9MTHFR, F2, F5
43thrombocytopenia9.9F2, F5
44cerebrovascular disease9.9F5, MTHFR, F2
45thromboembolism9.9MTHFR, F5, PROC, F2
46blood protein disease9.9PROS1, F2, MTHFR, F5
47antithrombin iii deficiency9.9F2, PROS1, MTHFR, F5
48protein s deficiency9.9F2, PROS1, F5, MTHFR
49antiphospholipid syndrome9.9F2, PROS1, MTHFR, F5
50hyperhomocysteinemia9.9MTHFR, F5, PROS1, F2

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to vein disease

Symptoms for Vein Disease

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Drugs & Therapeutics for Vein Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Vein Disease

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

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Anatomical Context for Vein Disease

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Sources:
14FMA
See all sources

FMA organs/tissues related to Vein Disease:

14
A vein

Animal Models for Vein Disease or affiliated genes

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Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Vein Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PROS1, PROC, EPAS1, F2
2MP:00053708.3F5, PROS1, PROC, EPAS1
3MP:00107718.0F2, PROS1, MTHFR, F5
4MP:00053857.8F2, EPAS1, PROC, PROS1, F5
5MP:00053807.8F2, EPAS1, PROS1, F5
6MP:00053787.6F2, EPAS1, PROC, MTHFR, F5
7MP:00036317.3F5, MTHFR, PROS1, PROC, EPAS1, F2
8MP:00053767.3F2, EPAS1, PROC, PROS1, MTHFR, F5
9MP:00107687.3F2, EPAS1, PROC, PROS1, MTHFR, F5

Publications for Vein Disease

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Sources:
52PubMed
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Articles related to Vein Disease:

(show all 36)
idTitleAuthorsYear
1
One-shot scleroembolization: a new technique for the treatment of varicose veins disease of lower extremities. Preliminary results. (23934946)
2013
2
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. (24126200)
2013
3
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. (22955688)
2013
4
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. (23997567)
2012
5
The significance of upper arm cephalic vein disease in vascular access creation. (23020965)
2012
6
A review of familial, genetic, and congenital aspects of primary varicose vein disease. (22896013)
2012
7
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (20881312)
2011
8
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. (21262580)
2011
9
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. (21690171)
2011
10
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. (21080204)
2011
11
Chronic venous insufficiency: current management of varicose vein disease. (20336886)
2010
12
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. (20227536)
2010
13
Minimally invasive vein surgery: latest options for vein disease. (20506452)
2010
14
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. (20632821)
2010
15
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. (18944196)
2008
16
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. (17294343)
2007
17
The economics of vein disease. (17911565)
2007
18
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). (18004259)
2007
19
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. (17985316)
2007
20
The histopathology of varicose vein disease. (17067976)
2006
21
Selection of saphenous vein conduit in varicose vein disease. (16564256)
2006
22
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). (15183051)
2004
23
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. (11907341)
2002
24
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. (12388823)
2002
25
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. (11259188)
2001
26
A unique virus complex causes Ageratum yellow vein disease. (10841581)
2000
27
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. (10544139)
1999
28
Symptomatology of vein disease. (7728483)
1995
29
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. (1728668)
1992
30
The management of varicose vein disease. (287952)
1979
31
The modern treatment of varicose vein disease. (4520459)
1973
32
Phlebography in varicose vein disease. (5014478)
1972
33
Mesenteric vein disease. (13740328)
1961
34
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. (13843232)
1960
35
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18111784)
1949
36
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. (18877800)
1948

Variations for Vein Disease

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Expression for genes affiliated with Vein Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for genes affiliated with Vein Disease

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 51PharmGKB, 54R&D Systems
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Pathways related to Vein Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3EPAS1, F2
2
Show member pathways
thioredoxin pathway38
9.3MTHFR, F2
3
Show member pathways
9.2PROS1, F5
4
Show member pathways
9.0PROS1, PROC, F2
5
Show member pathways
9.0F2, PROC, PROS1
6
Show member pathways
9.0PROS1, PROC, F2
7
Show member pathways
8.2F5, PROS1, PROC, F2
8
Show member pathways
8.2F5, PROS1, PROC, F2
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.2F2, PROC, PROS1, F5
10
Show member pathways
8.2F2, PROC, PROS1, F5

Compounds for genes affiliated with Vein Disease

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 3BitterDB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Vein Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
15-methyltetrahydrofolate45 1110.5MTHFR, F5
2inogatran459.5F5, F2
3cystathionine459.5F5, MTHFR
4ecarin459.5F2, F5
5hirugen459.5F2, F5
6spectrozyme459.5F2, F5
7danaparoid459.5F2, F5
8monoethylglycinexylidide459.4F2, F5
9batroxobin459.4F2, F5
10kaolin459.4F2, F5
11ximelagatran45 1110.4F2, F5
12ancrod459.4F2, F5
13heparinoids459.4F5, F2
14fondaparinux459.4F2, F5
15acenocoumarol45 51 1111.4F2, F5
16bivalirudin45 1110.4F2, F5
17coumarins459.4F2, F5
18desogestrel45 1110.4F2, F5
19argatroban45 1110.4F2, F5
20protamine sulfate459.4F5, F2
21gestodene45 1110.4F2, F5
22vitamin b6459.4MTHFR, F5
23ofloxacin45 3 1111.4F2, F5
24penicillin459.4F5, F2
25antipyrine45 1110.3F5, F2
26ristocetin459.3F5, F2
27cyproteroneacetate459.3F2, F5
28levonorgestrel45 61 29 1112.3F5, F2
29coumarin45 3 51 2412.3F5, F2
30desmopressin45 61 29 1112.3F5, F2
31cardiolipin45 1110.3F2, F5
32hirudin459.2F5, F2
33phosphatidylethanolamine45 1110.2F5, F2
34protamine459.2F2, F5
35dermatan sulfate459.1F5, F2
36kininogen459.0F2, F5
37acetaminophen45 3 51 24 1113.0F5, F2
38metformin45 51 1111.0F5, MTHFR
39homocysteine45 249.9F5, MTHFR, F2
40menadione45 24 1110.9F2, PROC, PROS1, MTHFR
41aspirin45 51 29 2411.9F5, MTHFR, F2
42vitamin b12458.8F5, MTHFR
43gamma-carboxyglutamic acid458.6F5, PROS1, PROC, F2
44phospholipid458.6F2, PROC, PROS1, F5
45aspartate458.6F5, MTHFR, F2
46warfarin45 51 24 1111.5F2, PROC, MTHFR, F5
47fibrinogen458.5F5, MTHFR, PROC, F2
48creatinine458.5F5, MTHFR, PROS1, F2
49heparin45 29 24 1111.1F2, PROC, PROS1, MTHFR, F5
50serine458.1F2, PROC, PROS1, MTHFR, F5

GO Terms for genes affiliated with Vein Disease

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Sources:
16Gene Ontology
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Cellular components related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.4PROS1, F2
2platelet alpha granule lumenGO:0310939.1F5, PROS1
3Golgi lumenGO:0057969.0PROS1, PROC, F2
4extracellular regionGO:0055767.9F2, PROC, PROS1, F5

Biological processes related to Vein Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.4PROS1, F2
2peptidyl-glutamic acid carboxylationGO:0171879.2PROS1, PROC, F2
3platelet degranulationGO:0025769.2F5, PROS1
4leukocyte migrationGO:0509009.2F2, PROC, PROS1
5proteolysisGO:0065089.1PROS1, PROC, F2
6post-translational protein modificationGO:0436879.1F2, PROC, PROS1
7blood circulationGO:0080159.0MTHFR, F5
8cellular protein metabolic processGO:0442678.7PROS1, PROC, F2
9platelet activationGO:0301688.6F5, PROS1, F2
10blood coagulationGO:0075968.4F5, PROS1, PROC, F2

Molecular functions related to Vein Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055099.0PROS1, PROC, F2
2serine-type endopeptidase activityGO:0042528.3F5, PROC, F2

Products for genes affiliated with Vein Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet