VGAM
MCID: VNF001
MIFTS: 19

Vein of Galen Aneurysm (VGAM) malady

Neuronal, Cardiovascular, Fetal categories

Summaries for Vein of Galen Aneurysm

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Vein of galen aneurysm is a rare form of arteriovenous malformation in which a particular vein at the base of the brain, the vein of galen, dilates causing too much blood to rush to the heart and leading to congestive heart failure. sometimes the defect will be recognized on an ultrasound before birth, but most often it is seen in infants who experience rapid heart failure. in less severe cases, a child may develop hydrocephalus because the enlarged malformation blocks the normal flow or absorption of cerebrospinal fluid. although the exact cause remains unknown, this condition appears to be a result of a defect in early fetal development. last updated: 9/15/2011

MalaCards: Vein of Galen Aneurysm, also known as vein of galen arteriovenous malformations, is related to heart aneurysm and spastic diplegia, and has symptoms including cerebral vascular anomalies, peripheral arteriovenous fistula and arterial aneurism (excluding aorta). An important gene associated with Vein of Galen Aneurysm is RASA1 (RAS p21 protein activator (GTPase activating protein) 1). Affiliated tissues include brain, heart and fetal brain.

Aliases & Classifications for Vein of Galen Aneurysm

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Neuronal, Cardiovascular


Characteristics (Orphanet epidemiological data):

49
vein of galen aneurysm:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

vein of galen aneurysm 43 49 61
vein of galen arteriovenous malformations 49
ectasia or varix of the vein of galen 43
vein of galen aneurysm malformation 43
galenic arteriovenous malformation 43
galen vein aneurysm 43
vgam 43


External Ids:

MESH via Orphanet36 C536535
ICD10 via Orphanet26 Q28.2
SNOMED-CT via Orphanet58 253194008
UMLS via Orphanet62 C0431420

Related Diseases for Vein of Galen Aneurysm

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1heart aneurysm10.5
2spastic diplegia10.3
3aseptic meningitis10.3
4turner syndrome10.3
5parkes weber syndrome10.3
6hemoglobinemia10.3
7weber syndrome10.3
8arteriovenous malformation10.3

Graphical network of diseases related to Vein of Galen Aneurysm:



Diseases related to vein of galen aneurysm

Clinical Features for Vein of Galen Aneurysm

Sources:
49Orphanet
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Symptoms:

49
  • cerebral vascular anomalies
  • peripheral arteriovenous fistula
  • arterial aneurism (excluding aorta)

Drugs & Therapeutics for Vein of Galen Aneurysm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vein of Galen Aneurysm

Anatomical Context for Vein of Galen Aneurysm

Sources:
33MalaCards
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MalaCards organs/tissues related to Vein of Galen Aneurysm:

33
Brain, Heart, Fetal brain

Animal Models for Vein of Galen Aneurysm or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Vein of Galen Aneurysm

Genetic Variations for Vein of Galen Aneurysm

Expression for genes affiliated with Vein of Galen Aneurysm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vein of Galen Aneurysm

Search GEO for disease gene expression data for Vein of Galen Aneurysm.

Pathways for genes affiliated with Vein of Galen Aneurysm

Compounds for genes affiliated with Vein of Galen Aneurysm

GO Terms for genes affiliated with Vein of Galen Aneurysm

Products for genes affiliated with Vein of Galen Aneurysm

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein of Galen Aneurysm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet