VGAM
MCID: VNF001
MIFTS: 22

Vein of Galen Aneurysm (VGAM) malady

Neuronal diseases, Cardiovascular diseases, Fetal diseases categories

Summaries for Vein of Galen Aneurysm

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Vein of galen aneurysm is a rare form of arteriovenous malformation in which a particular vein at the base of the brain, the vein of galen, dilates causing too much blood to rush to the heart and leading to congestive heart failure. sometimes the defect will be recognized on an ultrasound before birth, but most often it is seen in infants who experience rapid heart failure. in less severe cases, a child may develop hydrocephalus because the enlarged malformation blocks the normal flow or absorption of cerebrospinal fluid. although the exact cause remains unknown, this condition appears to be a result of a defect in early fetal development. last updated: 9/15/2011

MalaCards: Vein of Galen Aneurysm, also known as vein of galen arteriovenous malformations, is related to heart aneurysm and congestive heart failure, and has symptoms including cerebral vascular anomalies, peripheral arteriovenous fistula and arterial aneurism (excluding aorta). An important gene associated with Vein of Galen Aneurysm is RASA1 (RAS p21 protein activator (GTPase activating protein) 1). Affiliated tissues include brain and heart.

Aliases & Classifications for Vein of Galen Aneurysm

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Neuronal diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
vein of galen aneurysm:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

vein of galen aneurysm 42 48 60
vein of galen arteriovenous malformations 48
ectasia or varix of the vein of galen 42
vein of galen aneurysm malformation 42
galenic arteriovenous malformation 42
galen vein aneurysm 42
vgam 42


External Ids:

MESH via Orphanet35 C536535
ICD10 via Orphanet26 Q28.2
SNOMED-CT via Orphanet57 253194008
UMLS via Orphanet61 C0431420

Related Diseases for Vein of Galen Aneurysm

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17GeneCards, 18GeneDecks
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Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1heart aneurysm10.4
2congestive heart failure10.4
3hydrocephalus10.4
4spastic diplegia10.3
5aseptic meningitis10.3
6galactosemia10.3
7hypertension10.3
8meningitis10.3
9arteriovenous malformation10.2

Graphical network of diseases related to Vein of Galen Aneurysm:



Diseases related to vein of galen aneurysm

Clinical Features for Vein of Galen Aneurysm

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48Orphanet
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Symptoms:

48
  • cerebral vascular anomalies
  • peripheral arteriovenous fistula
  • arterial aneurism (excluding aorta)

Drugs & Therapeutics for Vein of Galen Aneurysm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Vein of Galen Aneurysm

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Anatomical Context for Vein of Galen Aneurysm

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32MalaCards
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MalaCards organs/tissues related to Vein of Galen Aneurysm:

32
Brain, Heart

Animal Models for Vein of Galen Aneurysm or affiliated genes

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Publications for Vein of Galen Aneurysm

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Genetic Variations for Vein of Galen Aneurysm

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Expression for genes affiliated with Vein of Galen Aneurysm

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vein of Galen Aneurysm

Search GEO for disease gene expression data for Vein of Galen Aneurysm.

Pathways for genes affiliated with Vein of Galen Aneurysm

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Compounds for genes affiliated with Vein of Galen Aneurysm

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GO Terms for genes affiliated with Vein of Galen Aneurysm

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Products for genes affiliated with Vein of Galen Aneurysm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vein of Galen Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet