VGAM
MCID: VNF001
MIFTS: 30

Vein of Galen Aneurysm (VGAM) malady

Rare diseases, Neuronal diseases, Cardiovascular diseases, Fetal diseases categories
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Summaries for Vein of Galen Aneurysm

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NIH Rare Diseases:42 Vein of galen aneurysm is a rare form of arteriovenous malformation in which a particular vein at the base of the brain, the vein of galen, dilates causing too much blood to rush to the heart and leading to congestive heart failure. sometimes the defect will be recognized on an ultrasound before birth, but most often it is seen in infants who experience rapid heart failure. in less severe cases, a child may develop hydrocephalus because the enlarged malformation blocks the normal flow or absorption of cerebrospinal fluid. although the exact cause remains unknown, this condition appears to be a result of a defect in early fetal development. last updated: 9/15/2011

MalaCards based summary: Vein of Galen Aneurysm, also known as vein of galen aneurysm malformation, is related to aneurysm and congestive heart failure, and has symptoms including cerebral vascular anomalies, peripheral arteriovenous fistula and arterial aneurism (excluding aorta). An important gene associated with Vein of Galen Aneurysm is RASA1 (RAS p21 protein activator (GTPase activating protein) 1). Affiliated tissues include heart, brain and pineal.

Aliases & Classifications for Vein of Galen Aneurysm

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Vein of Galen Aneurysm, Aliases & Descriptions:

Name: Vein of Galen Aneurysm 42 48 62
Vein of Galen Aneurysm Malformation 42 62
Galenic Arteriovenous Malformation 42 62
Vein of Galen Arteriovenous Malformations 48
 
Ectasia or Varix of the Vein of Galen 42
Galen Vein Aneurysm 42
Vgam 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
vein of galen aneurysm:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


External Ids:

MESH via Orphanet35 C536535
ICD10 via Orphanet26 Q28.2
UMLS via Orphanet63 C0431420

Related Diseases for Vein of Galen Aneurysm

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Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm11.2
2congestive heart failure10.5
3hydrocephalus10.5
4hypertension10.3
5pulmonary hypertension10.3
6aseptic meningitis10.3
7spastic diplegia10.3
8arteriovenous malformation10.3
9galactosemia10.3
10meningitis10.3
11hemoglobinemia10.3
12parkes weber syndrome10.3
13weber syndrome10.3
14spasticity10.3

Graphical network of diseases related to Vein of Galen Aneurysm:



Diseases related to vein of galen aneurysm

Symptoms for Vein of Galen Aneurysm

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Symptoms:

48
  • cerebral vascular anomalies
  • peripheral arteriovenous fistula
  • arterial aneurism (excluding aorta)

HPO human phenotypes related to Vein of Galen Aneurysm:

id Description Frequency HPO Source Accession
1 abnormality of the cerebral vasculature hallmark (90%) HP:0100659
2 aneurysm typical (50%) HP:0002617
3 peripheral arteriovenous fistula typical (50%) HP:0100784

Drugs & Therapeutics for Vein of Galen Aneurysm

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Drug clinical trials:

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Genetic Tests for Vein of Galen Aneurysm

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Anatomical Context for Vein of Galen Aneurysm

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MalaCards organs/tissues related to Vein of Galen Aneurysm:

32
Heart, Brain, Pineal

Animal Models for Vein of Galen Aneurysm or affiliated genes

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Publications for Vein of Galen Aneurysm

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Articles related to Vein of Galen Aneurysm:

(show all 50)
idTitleAuthorsYear
1
Pure word deafness after resection of a Vein of Galen aneurysm and arteriovenous malformation: report of a case. (24956543)
2014
2
Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult. (23713094)
2013
3
Endovascular management of vein of galen aneurysm malformation: A series of two case reports. (21977085)
2011
4
MR and Diffusion Tensor Imaging of Vein of Galen Aneurysmal Malformation in an Infant Presenting with Spastic Diplegia and Seizures. A Case Report. (24148343)
2010
5
Confirmation of T1-bright vein of Galen aneurysm spontaneous thrombosis by subtraction magnetic resonance venography: a case report. (19626473)
2009
6
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. (18446851)
2008
7
Prenatal magnetic resonance imaging of vein of Galen aneurysm associated with congestive heart failure. (19067899)
2008
8
Vein of Galen aneurysmal malformation and galactosemia in a neonate: a previously unreported association. (17986048)
2007
9
Vein of Galen aneurysm in an adult: case report. (17057899)
2006
10
Vein of Galen aneurysm complicated with pulmonary hypertension: report of one newborn case. (17016967)
2006
11
Vein of Galen aneurysm: antenatal diagnosis: a case report. (16304858)
2005
12
Spectrum of clinical presentations of vein of galen aneurysm. (15163883)
2004
13
Vein of Galen aneurysm malformation (VGAM): closing the management loop. (15055912)
2004
14
Vein of Galen aneurysm: anatomical study of an adult autopsy case. (15300864)
2004
15
Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics. (12812929)
2003
16
Prenatal diagnosis of a vein of galen aneurysm. (12566774)
2003
17
Surgical treatment of the thrombosed vein of galen aneurysm. (12376772)
2002
18
Disseminated coagulopathy associated with transtorcular embolization of vein of Galen aneurysm in a neonate. (10685204)
1999
19
Prenatal diagnosis and prognosis of a vein of Galen aneurysm assessed by pulsed and color Doppler sonography. (8705421)
1996
20
Special imaging casebook. Vein of Galen aneurysm. (8817440)
1996
21
A vein of Galen aneurysm with an abnormal drain system: MRI findings. (7491195)
1995
22
Prenatal sonographic diagnosis of a vein of Galen aneurysm: relevance of associated malformations for timing and mode of delivery. (8590193)
1995
23
Pathologic findings in a patient with a vein of Galen aneurysm treated by staged endovascular embolization. (8481943)
1993
24
The increase in plethysmographic amplitude due to the clipping of the vein of Galen aneurysm. (8346849)
1993
25
Prenatal magnetic resonance imaging detection of a vein of Galen aneurysm. (8306350)
1993
26
Color Doppler sonography as a primary diagnostic tool in the diagnosis of vein of Galen aneurysm in a critically ill neonate. (7904055)
1993
27
Vein of Galen aneurysm: MRI with a fast gradient refocusing pulse sequence. (8332410)
1993
28
Early diagnosis of a vein of Galen aneurysm: report of a case. (1363216)
1992
29
Case report: in utero diagnosis of a vein of Galen aneurysm using colour flow Doppler. (1959310)
1991
30
Vein of Galen aneurysm and hydrocephalus. (1794114)
1991
31
Vein of Galen aneurysm presenting with recurrent aseptic meningitis and subsequent spontaneous thrombosis. (2330533)
1990
32
Vein of Galen aneurysm. (2228099)
1990
33
Vein of Galen aneurysm associated with dural AVM and straight sinus thrombosis. Case report. (3339446)
1988
34
Successful surgical and anesthetic management of vein of Galen aneurysm in a neonate in congestive heart failure. (3380281)
1988
35
Anesthetic management of hemodynamic changes during vein of Galen aneurysm clipping. (3195776)
1988
36
Spontaneous thrombosis of a vein of Galen aneurysm. (3120540)
1987
37
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. (3614590)
1987
38
In utero diagnosis of a vein of Galen aneurysm by ultrasound. (6399929)
1984
39
Vascular steal associated with vein of Galen aneurysm. (6544380)
1984
40
Vein of Galen aneurysm. (6619087)
1983
41
Thrombosed vein of Galen aneurysm. (7070623)
1982
42
Unusual manifestation of vein of Galen aneurysm. (6810676)
1982
43
Diagnosis of a vein of Galen aneurysm by ultrasound. (6811625)
1982
44
Vein of Galen aneurysm - diagnosis by real-time ultrasound. (7328101)
1981
45
Turner's syndrome and vein of Galen aneurysm--a previously unreported association. (7349577)
1981
46
Hydrocephalus associated with arterio-venous malformation - the vein of Galen aneurysm. (551620)
1979
47
Vein of Galen aneurysm: successful excision of a completely thrombosed aneurysm in an infant. (4810450)
1974
48
Vein of Galen aneurysm. (4722476)
1973
49
Pneumoencephalographic findings in a case of vein of Galen aneurysm. (5117054)
1971
50
Excision of thrombosed vein of Galen aneurysm in an infant. Case report. (5304310)
1968

Variations for Vein of Galen Aneurysm

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Expression for genes affiliated with Vein of Galen Aneurysm

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Expression patterns in normal tissues for genes affiliated with Vein of Galen Aneurysm

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Pathways for genes affiliated with Vein of Galen Aneurysm

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Compounds for genes affiliated with Vein of Galen Aneurysm

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GO Terms for genes affiliated with Vein of Galen Aneurysm

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Products for genes affiliated with Vein of Galen Aneurysm

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Sources for Vein of Galen Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet