MCID: VNF001
MIFTS: 27

Vein of Galen Aneurysm

Categories: Rare diseases, Cardiovascular diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Vein of Galen Aneurysm

MalaCards integrated aliases for Vein of Galen Aneurysm:

Name: Vein of Galen Aneurysm 49 55 69
Vein of Galen Arteriovenous Malformations 55
Ectasia or Varix of the Vein of Galen 49
Vein of Galen Aneurysm Malformation 49
Galenic Arteriovenous Malformation 49
Galen Vein Aneurysm 49
Vgam 49

Characteristics:

Orphanet epidemiological data:

55
vein of galen aneurysm
Inheritance: Not applicable; Age of onset: Antenatal,Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 55 ORPHA1053
MESH via Orphanet 42 C536535
UMLS via Orphanet 70 C0431420
ICD10 via Orphanet 33 Q28.2
SNOMED-CT via HPO 65 432119003 85659009
UMLS 69 C0431420

Summaries for Vein of Galen Aneurysm

NIH Rare Diseases : 49 Vein of Galen aneurysm is a rare form of arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings.  Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization. Last updated: 9/11/2016

MalaCards based summary : Vein of Galen Aneurysm, also known as vein of galen arteriovenous malformations, is related to aneurysm and complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy, and has symptoms including abnormality of the cerebral vasculature, peripheral arteriovenous fistula and aneurysm. Affiliated tissues include heart, brain and pineal.

Related Diseases for Vein of Galen Aneurysm

Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 aneurysm 10.8
2 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.2
3 thrombosis 10.2
4 congestive heart failure 10.1
5 hydrocephalus 10.1
6 arteriovenous malformation 9.9
7 aseptic meningitis 9.9
8 meningitis 9.9
9 hemoglobinemia 9.9
10 weber syndrome 9.9
11 spasticity 9.9
12 galactosemia 9.9
13 aging 9.9
14 branchiootic syndrome 1 9.9
15 parkes weber syndrome 9.9
16 pulmonary hypertension 9.9
17 spastic diplegia 9.9

Graphical network of the top 20 diseases related to Vein of Galen Aneurysm:



Diseases related to Vein of Galen Aneurysm

Symptoms & Phenotypes for Vein of Galen Aneurysm

Human phenotypes related to Vein of Galen Aneurysm:

55 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the cerebral vasculature 55 31 hallmark (90%) Very frequent (99-80%) HP:0100659
2 peripheral arteriovenous fistula 55 31 frequent (33%) Frequent (79-30%) HP:0100784
3 aneurysm 55 Frequent (79-30%)
4 dilatation 31 frequent (33%) HP:0002617

Drugs & Therapeutics for Vein of Galen Aneurysm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety of Apollo Micro Catheter in Pediatric Patients Completed NCT02085278

Search NIH Clinical Center for Vein of Galen Aneurysm

Genetic Tests for Vein of Galen Aneurysm

Anatomical Context for Vein of Galen Aneurysm

MalaCards organs/tissues related to Vein of Galen Aneurysm:

38
Heart, Brain, Pineal

Publications for Vein of Galen Aneurysm

Articles related to Vein of Galen Aneurysm:

(show top 50) (show all 52)
# Title Authors Year
1
EP02.09: Early and uncommon prenatal diagnosis of vein of Galen aneurysm. ( 27645455 )
2016
2
Pure word deafness after resection of a Vein of Galen aneurysm and arteriovenous malformation: report of a case. ( 24956543 )
2014
3
Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult. ( 23713094 )
2013
4
Endovascular management of vein of galen aneurysm malformation: A series of two case reports. ( 21977085 )
2011
5
MR and Diffusion Tensor Imaging of Vein of Galen Aneurysmal Malformation in an Infant Presenting with Spastic Diplegia and Seizures. A Case Report. ( 24148343 )
2010
6
Confirmation of T1-bright vein of Galen aneurysm spontaneous thrombosis by subtraction magnetic resonance venography: a case report. ( 19626473 )
2009
7
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. ( 18446851 )
2008
8
Prenatal magnetic resonance imaging of vein of Galen aneurysm associated with congestive heart failure. ( 19067899 )
2008
9
Vein of Galen aneurysmal malformation and galactosemia in a neonate: a previously unreported association. ( 17986048 )
2007
10
Vein of Galen aneurysm complicated with pulmonary hypertension: report of one newborn case. ( 17016967 )
2006
11
Vein of Galen aneurysm in an adult: case report. ( 17057899 )
2006
12
Vein of Galen aneurysm: antenatal diagnosis: a case report. ( 16304858 )
2005
13
Vein of Galen aneurysm malformation (VGAM): closing the management loop. ( 15055912 )
2004
14
Spectrum of clinical presentations of vein of galen aneurysm. ( 15163883 )
2004
15
Vein of Galen aneurysm: anatomical study of an adult autopsy case. ( 15300864 )
2004
16
Prenatal diagnosis of a vein of galen aneurysm. ( 12566774 )
2003
17
Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics. ( 12812929 )
2003
18
Surgical treatment of the thrombosed vein of galen aneurysm. ( 12376772 )
2002
19
Disseminated coagulopathy associated with transtorcular embolization of vein of Galen aneurysm in a neonate. ( 10685204 )
1999
20
Prenatal diagnosis and prognosis of a vein of Galen aneurysm assessed by pulsed and color Doppler sonography. ( 8705421 )
1996
21
Special imaging casebook. Vein of Galen aneurysm. ( 8817440 )
1996
22
Prenatal sonographic diagnosis of a vein of Galen aneurysm: relevance of associated malformations for timing and mode of delivery. ( 8590193 )
1995
23
A vein of Galen aneurysm with an abnormal drain system: MRI findings. ( 7491195 )
1995
24
Pathologic findings in a patient with a vein of Galen aneurysm treated by staged endovascular embolization. ( 8481943 )
1993
25
The increase in plethysmographic amplitude due to the clipping of the vein of Galen aneurysm. ( 8346849 )
1993
26
Prenatal magnetic resonance imaging detection of a vein of Galen aneurysm. ( 8306350 )
1993
27
Color Doppler sonography as a primary diagnostic tool in the diagnosis of vein of Galen aneurysm in a critically ill neonate. ( 7904055 )
1993
28
Vein of Galen aneurysm: MRI with a fast gradient refocusing pulse sequence. ( 8332410 )
1993
29
Early diagnosis of a vein of Galen aneurysm: report of a case. ( 1363216 )
1992
30
Vein of Galen aneurysm presenting in middle age. ( 1449674 )
1992
31
Vein of Galen aneurysm and hydrocephalus. ( 1794114 )
1991
32
Case report: in utero diagnosis of a vein of Galen aneurysm using colour flow Doppler. ( 1959310 )
1991
33
Vein of Galen aneurysm presenting with recurrent aseptic meningitis and subsequent spontaneous thrombosis. ( 2330533 )
1990
34
Vein of Galen aneurysm. ( 2228099 )
1990
35
Vein of Galen aneurysm associated with dural AVM and straight sinus thrombosis. Case report. ( 3339446 )
1988
36
Anesthetic management of hemodynamic changes during vein of Galen aneurysm clipping. ( 3195776 )
1988
37
Successful surgical and anesthetic management of vein of Galen aneurysm in a neonate in congestive heart failure. ( 3380281 )
1988
38
Spontaneous thrombosis of a vein of Galen aneurysm. ( 3120540 )
1987
39
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. ( 3614590 )
1987
40
In utero diagnosis of a vein of Galen aneurysm by ultrasound. ( 6399929 )
1984
41
Vascular steal associated with vein of Galen aneurysm. ( 6544380 )
1984
42
Vein of Galen aneurysm. ( 6619087 )
1983
43
Diagnosis of a vein of Galen aneurysm by ultrasound. ( 6811625 )
1982
44
Unusual manifestation of vein of Galen aneurysm. ( 6810676 )
1982
45
Thrombosed vein of Galen aneurysm. ( 7070623 )
1982
46
Vein of Galen aneurysm - diagnosis by real-time ultrasound. ( 7328101 )
1981
47
Turner's syndrome and vein of Galen aneurysm--a previously unreported association. ( 7349577 )
1981
48
Hydrocephalus associated with arterio-venous malformation - the vein of Galen aneurysm. ( 551620 )
1979
49
Vein of Galen aneurysm: successful excision of a completely thrombosed aneurysm in an infant. ( 4810450 )
1974
50
Vein of Galen aneurysm. ( 4722476 )
1973

Variations for Vein of Galen Aneurysm

Expression for Vein of Galen Aneurysm

Search GEO for disease gene expression data for Vein of Galen Aneurysm.

Pathways for Vein of Galen Aneurysm

GO Terms for Vein of Galen Aneurysm

Sources for Vein of Galen Aneurysm

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10 dbSNP
11 DGIdb
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33 ICD10 via Orphanet
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50 NINDS
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53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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