MCID: VNZ002
MIFTS: 45

Venezuelan Equine Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

Aliases & Descriptions for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 12 50 14
Encephalomyelitis, Venezuelan Equine 42
Venezuelan Equine Encephalomyelitis 69
Encephalitis Venezuelan Equine 52
Venezuelan Equine Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9584
ICD10 33 A92.2
ICD9CM 35 066.2
MeSH 42 D004685
NCIt 47 C35121
UMLS 69 C0014078

Summaries for Venezuelan Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary : Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to encephalitis and mucositis, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Vaccines and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are hematopoietic system and neoplasm

Related Diseases for Venezuelan Equine Encephalitis

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to Venezuelan Equine Encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

Symptoms:

12
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 IFNB1 IRF1 IRF7 LGALS3 RPSA STAT1
2 neoplasm MP:0002006 9.02 STAT1 IFNB1 IRF1 LGALS3 SAT1

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Mitogens Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine Enrolling by invitation NCT00582504 Phase 2
2 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine in Healthy Adults Not yet recruiting NCT03051386 Phase 2
3 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83 Suspended NCT00582088 Phase 2
4 Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers Completed NCT01984983 Phase 1
5 A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901 Active, not recruiting NCT01526473 Phase 1
6 Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine Withdrawn NCT00109304 Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

39
Brain, T Cells, Testes, Myeloid, Spleen, Pancreas, Olfactory Bulb

The Foundational Model of Anatomy Ontology organs/tissues related to Venezuelan Equine Encephalitis:

18
Brain Of Horses

Publications for Venezuelan Equine Encephalitis

Articles related to Venezuelan Equine Encephalitis:

(show top 50) (show all 428)
id Title Authors Year
1
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. ( 27852852 )
2017
2
Altered mitochondrial dynamics as a consequence of Venezuelan Equine Encephalitis Virus infection. ( 28075229 )
2017
3
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. ( 27054586 )
2016
4
Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. ( 27101567 )
2016
5
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells. ( 27105836 )
2016
6
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. ( 27318152 )
2016
7
Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure. ( 27334491 )
2016
8
Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood. ( 27870591 )
2016
9
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. ( 27105216 )
2016
10
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease. ( 27261892 )
2016
11
A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA. ( 28042576 )
2016
12
The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. ( 26656680 )
2016
13
Bibliometric assessment of global research on Venezuelan Equine Encephalitis: A latent threat for the Americas. ( 27640115 )
2016
14
Mayaro, Oropouche and Venezuelan Equine Encephalitis viruses: Following in the footsteps of Zika? ( 27826073 )
2016
15
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. ( 27206386 )
2016
16
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. ( 26792742 )
2016
17
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. ( 27129427 )
2016
18
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. ( 27030368 )
2016
19
Role of angiotensin II in experimental Venezuelan equine encephalitis in rats. ( 26156105 )
2015
20
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research. ( 26041283 )
2015
21
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015
22
Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus. ( 27503577 )
2015
23
Genetic diversity of Venezuelan alphaviruses and circulation of a Venezuelan equine encephalitis virus subtype IAB strain during an interepizootic period. ( 25940191 )
2015
24
Demographics of natural oral infection of mosquitos by venezuelan equine encephalitis virus. ( 25589654 )
2015
25
The ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection. ( 25927990 )
2015
26
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain. ( 25725151 )
2015
27
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. ( 26168898 )
2015
28
Correction: IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. ( 26107877 )
2015
29
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. ( 26020513 )
2015
30
NMR study of non-structural proteins-part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). ( 25291978 )
2014
31
Genetic and evolutionary characterization of Venezuelan equine encephalitis virus isolates from Argentina. ( 24833218 )
2014
32
The role of IKKI^ in Venezuelan equine encephalitis virus infection. ( 24586253 )
2014
33
Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. ( 24967809 )
2014
34
Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. ( 25320296 )
2014
35
Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. ( 24125177 )
2014
36
Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication. ( 25448087 )
2014
37
Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus. ( 25244572 )
2014
38
IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice. ( 23351391 )
2013
39
Venezuelan equine encephalitis virus glycoprotein pseudotyping confers neurotropism to lentiviral vectors. ( 23171919 )
2013
40
Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication. ( 24161512 )
2013
41
Venezuelan equine encephalitis replicon particles can induce rapid protection against foot-and-mouth disease virus. ( 23468490 )
2013
42
Pathogenesis of Venezuelan equine encephalitis. ( 23968890 )
2013
43
Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus. ( 23988697 )
2013
44
Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation. ( 23221545 )
2013
45
Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication. ( 23637407 )
2013
46
CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. ( 24210643 )
2013
47
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus. ( 23408633 )
2013
48
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions. ( 23365438 )
2013
49
IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety. ( 23675542 )
2013
50
Venezuelan Equine Encephalitis Viruses (VEEV) in Argentina: Serological Evidence of Human Infection. ( 24349588 )
2013

Variations for Venezuelan Equine Encephalitis

Expression for Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for Venezuelan Equine Encephalitis

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 IFNB1 IL32 IRF1 IRF7 STAT1
2
Show member pathways
12.63 IFNB1 IRF1 IRF7 STAT1
3
Show member pathways
12.38 IFNB1 IRF1 IRF7
4 12.12 IRF1 IRF7 LGALS3 STAT1
5
Show member pathways
12.05 IFNB1 IRF1 IRF7 STAT1
6
Show member pathways
11.83 IFNB1 IRF1 STAT1
7 11.78 IFNB1 IRF1 IRF7
8 11.57 IFNB1 IRF1 IRF7
9
Show member pathways
11.52 IRF1 STAT1
10
Show member pathways
11.51 IRF1 STAT1
11 11.47 IRF1 STAT1
12 11.43 IFNB1 IRF7
13 11.37 IFNB1 IRF1 IRF7 STAT1
14 11.36 IFNB1 STAT1
15 11.34 LGALS3 STAT1
16
Show member pathways
11.13 IFNB1 IRF1 IRF7 STAT1
17 10.9 IFNB1 IRF1 STAT1
18
Show member pathways
10.84 IRF7 STAT1

GO Terms for Venezuelan Equine Encephalitis

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.78 IFNB1 IRF1 IRF7 STAT1
2 viral process GO:0016032 9.69 IRF7 RPSA STAT1
3 defense response to virus GO:0051607 9.56 IFNB1 IRF1 IRF7 STAT1
4 interferon-gamma-mediated signaling pathway GO:0060333 9.5 IRF1 IRF7 STAT1
5 epithelial cell differentiation GO:0030855 9.49 LGALS3 RPSA
6 positive regulation of type I interferon production GO:0032481 9.46 IRF1 IRF7
7 regulation of type I interferon-mediated signaling pathway GO:0060338 9.43 IFNB1 STAT1
8 positive regulation of interferon-beta production GO:0032728 9.4 IRF1 IRF7
9 regulation of adaptive immune response GO:0002819 9.37 IRF1 IRF7
10 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.16 IRF1 IRF7
11 cellular response to interferon-beta GO:0035458 9.13 IFNB1 IRF1 STAT1
12 type I interferon signaling pathway GO:0060337 8.92 IFNB1 IRF1 IRF7 STAT1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 IRF7 STAT1
2 laminin binding GO:0043236 8.96 LGALS3 RPSA
3 regulatory region DNA binding GO:0000975 8.62 IRF1 IRF7

Sources for Venezuelan Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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