MCID: VNZ002
MIFTS: 52

Venezuelan Equine Encephalitis malady

Summaries for Venezuelan Equine Encephalitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in venezuelan equine encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards: Venezuelan Equine Encephalitis, also known as venezuelan equine encephalomyelitis, is related to encephalitis and eastern equine encephalitis, and has symptoms including myalgia in the legs, photophobia and severe headache. An important gene associated with Venezuelan Equine Encephalitis is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are IL-22 Pathway and IL27-mediated signaling events. The compounds mumps and vanadate have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, brain and t cells, and related mouse phenotypes are normal and cellular.

Wikipedia:63 Venezuelan equine encephalitis virus is a mosquito-borne viral pathogen that causes Venezuelan equine... more...

Aliases & Classifications for Venezuelan Equine Encephalitis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

venezuelan equine encephalitis 8 42 10
venezuelan equine encephalomyelitis 60
encephalitis venezuelan equine 44


External Ids:

Disease Ontology8 DOID:9584
ICD9CM27 066.2
MeSH34 D004685
NCIt39 C35121

Related Diseases for Venezuelan Equine Encephalitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.3CCL2
2eastern equine encephalitis31.0SH2D3C
3vaccinia30.9FURIN
4chikungunya30.6SH2D3C, SH2D3A
5yellow fever30.4PRNT
6mumps30.4STAT2, STAT1
7hepatitis30.4STAT1, IFNB1
8influenza30.4STAT1, IFNB1, FURIN
9western equine encephalitis10.7
10viral encephalitis10.6
11tick-borne encephalitis10.5
12st. louis encephalitis10.4
13neuronitis10.4
14rift valley fever10.3
15cowpox10.3
16venezuelan hemorrhagic fever10.3
17ebola hemorrhagic fever10.3
18cerebritis10.3
19west nile fever10.3
20japanese encephalitis10.3
21lyme disease10.3
22hepatitis a10.3
23encephalomyelitis10.3
24herpes simplex10.3
25mouth disease10.3
26stomatitis10.3
27west nile encephalitis10.3
28severe acute respiratory syndrome10.0SH2D3C, SH2D3A
29myeloid leukemia10.0STAT1, STAT2
30chronic inflammatory demyelinating polyradiculoneuropathy10.0IFNB1
31hepatocellular carcinoma10.0IL32, IFNB1
32glioblastoma multiforme10.0STAT1, LGALS3
33myeloma10.0TYK2, STAT1
34measles10.0STAT1, IFNB1
35hepatitis c10.0TYK2, STAT1, IFNB1
36fibrosarcoma10.0STAT2, IFNB1, TYK2, STAT1
37prostate cancer10.0TYK2, STAT1, LGALS3, IL32
38sarcoidosis10.0CCL2, STAT1
39tuberculosis10.0STAT2, STAT1, IFNB1, RAB5A
40ovarian cancer10.0SAT1, IFNB1, RPSA, FURIN
41leukemia10.0STAT1, SAT1, IFNB1, ERF, TYK2
42colon cancer10.0TYK2, FURIN, IFNB1, LGALS3, STAT1
43allergic asthma10.0CCL2, STAT1, IFNB1
44arthritis10.0CCL2, STAT1, IL32
45malignant glioma10.0IFNB1, STAT1, IL32, LGALS3, FURIN
46systemic lupus erythematosus10.0CCL2, TYK2, STAT1, IFNB1
47multiple sclerosis10.0STAT1, IFNB1, CCL2
48rheumatoid arthritis10.0CCL2, IFNB1, TYK2, IL32, STAT1
49melanoma10.0RPSA, IFNB1, LGALS3, STAT1, STAT2, SAT1
50burkitt's lymphoma10.0FURIN, LGALS3, TYK2, STAT1, RPSA

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Clinical Features for Venezuelan Equine Encephalitis

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • myalgia in the legs
  • photophobia
  • severe headache
  • malaise
  • chills
  • fever

Drugs & Therapeutics for Venezuelan Equine Encephalitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Venezuelan Equine Encephalitis

Drug clinical trials:

Search ClinicalTrials for Venezuelan Equine Encephalitis

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Search CenterWatch for Venezuelan Equine Encephalitis

Genetic Tests for Venezuelan Equine Encephalitis

About this section

Anatomical Context for Venezuelan Equine Encephalitis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

32
Brain, T cells, Olfactory bulb, Myeloid, Testes, Pancreas, Kidney, Spleen

FMA organs/tissues related to Venezuelan Equine Encephalitis:

14
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4CCL2, IFNB1, SAT1, STAT1, RAB7A, ERF
2MP:00053848.2IFNB1, SAT1, STAT2, STAT1, SH2D3C, TYK2
3MP:00053977.9LGALS3, RPSA, CCL2, IFNB1, STAT2, STAT1

Publications for Venezuelan Equine Encephalitis

About this section
Sources:
50PubMed
See all sources

Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions. (23365438)
2013
2
Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication. (24161512)
2013
3
Venezuelan equine encephalitis in a teenager visiting Central America. (22472656)
2012
4
A DNA vaccine for venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates. (21450977)
2011
5
Microbead electrochemiluminescence immunoassay for detection and identification of Venezuelan equine encephalitis virus. (20678522)
2010
6
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. (19386706)
2009
7
Replicon particles of Venezuelan equine encephalitis virus as a reductionist murine model for encephalitis. (19225006)
2009
8
A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32. (18768856)
2008
9
Venezuelan equine encephalitis virus infection of cotton rats. (17953085)
2007
10
Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques (Macaca fascicularis). (17727720)
2007
11
Vaccination of mice with gonococcal TbpB expressed in vivo from Venezuelan equine encephalitis viral replicon particles. (16495532)
2006
12
Tunicamycin enhances neuroinvasion and encephalitis in mice infected with Venezuelan equine encephalitis virus. (17099147)
2006
13
Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses. (16501087)
2006
14
A novel, rapid assay for detection and differentiation of serotype-specific antibodies to Venezuelan equine encephalitis complex alphaviruses. (15964967)
2005
15
Venezuelan equine encephalitis virus in the guinea pig model: evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene. (15772331)
2005
16
Venezuelan equine encephalitis virus infection of spiny rats. (15890116)
2005
17
Environmental hazard assessment of Venezuelan equine encephalitis virus vaccine candidate strain V3526. (15193393)
2004
18
Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus. (12922144)
2003
19
Influence of venezuelan equine encephalitis, influenza and mumps vaccine viral strains on morphological patterns and viability of human tumor cells in vitro. (17415867)
2003
20
Structure of isolated nucleocapsids from venezuelan equine encephalitis virus and implications for assembly and disassembly of enveloped virus. (12477868)
2003
21
Short report: Isolation and identification of Venezuelan equine encephalitis virus from a human in Panama. (12363053)
2002
22
Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses. (12083816)
2002
23
Comparative neurovirulence of attenuated and non-attenuated strains of Venezuelan equine encephalitis virus in mice. (11792007)
2001
24
Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor. (10196323)
1999
25
Sequencing of prototype viruses in the Venezuelan equine encephalitis antigenic complex. (10500282)
1999
26
Development of a functional monoclonal single-chain variable fragment antibody against Venezuelan equine encephalitis virus. (10600028)
1999
27
Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico. (9684636)
1998
28
Genetic targets for the detection and identification of Venezuelan equine encephalitis viruses. (9638144)
1998
29
Induction of protective immune responses against Venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccine. (9682396)
1998
30
Improved protection against Venezuelan equine encephalitis by genetic engineering of a recombinant vaccinia virus. (9918402)
1998
31
Comparative neurovirulence and tissue tropism of wild-type and attenuated strains of Venezuelan equine encephalitis virus administered by aerosol in C3H/HeN and BALB/c mice. (9754544)
1998
32
Use of telemetry to assess vaccine-induced protection against parenteral and aerosol infections of Venezuelan equine encephalitis virus in non-human primates. (9682359)
1998
33
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
34
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
35
Mucosal immunity induced by parenteral immunization with a live attenuated Venezuelan equine encephalitis virus vaccine candidate. (9123821)
1997
36
Virulent and attenuated mutant Venezuelan equine encephalitis virus show marked differences in replication in infection in murine macrophages. (8844652)
1996
37
A putative receptor for Venezuelan equine encephalitis virus from mosquito cells. (8764073)
1996
38
Arbovirus studies in the Guajira region of Venezuela: activities of eastern equine encephalitis and Venezuelan equine encephalitis viruses during an interepizootic period. (6148023)
1984
39
Identification of a new Venezuelan equine encephalitis virus from Brazil. (7149112)
1982
40
Clinical aspects of human Venezuelan equine encephalitis in Texas. (949558)
1976
41
Evaluation in donkeys on an inactivated Venezuelan equine encephalitis vaccine. (1130149)
1975
42
Epidemic Venezuelan equine encephalitis in North America: a summary of virus-vector-host relationships. (235211)
1975
43
Human Venezuelan equine encephalitis virus infection in Florida. (4823800)
1974
44
Venezuelan equine encephalitis epidemic in Texas, 1971. (4151413)
1974
45
Surveillance of Venezuelan equine encephalitis in the United States--1972. (4149690)
1973
46
Inactivated complement fixing antigen from Venezuelan equine encephalitis virus grown in tissue culture. (5125543)
1971
47
Effect of relative humidity and temperature on airborne Venezuelan equine encephalitis virus. (4999523)
1971
48
Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance. (5773424)
1969
49
Epidemiological aspects of venezuelan equine encephalitis virus infections. (16350203)
1967
50
Electron microscopic and biological studies on the growth of Venezuelan equine encephalitis virus in KB cells. (14477588)
1962

Genetic Variations for Venezuelan Equine Encephalitis

About this section

Expression for genes affiliated with Venezuelan Equine Encephalitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 29KEGG, 53Reactome
See all sources

Pathways related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2, STAT1
2
Hide members
9.9STAT2, STAT1, TYK2
39.9TYK2, STAT1, STAT2
4
Hide members
9.9TYK2, STAT1, STAT2
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.9TYK2, STAT1, STAT2
6
Hide members
9.9STAT1, TYK2, RAB7A
79.9RAB7A, IFNB1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.8CCL2, STAT1, TYK2
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.8TYK2, STAT1, CCL2
109.7IFNB1, STAT2, STAT1
119.5TYK2, STAT1, STAT2, IFNB1
129.5TYK2, STAT1, STAT2, IFNB1
139.5IFNB1, STAT2, STAT1, TYK2
14
Immune response IFN alpha/beta signaling pathway
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
159.5IFNB1, STAT2, STAT1, TYK2
16
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
17
Hide members
9.4STAT1, STAT2, IFNB1, CCL2
189.4RAB5A, SH2D3C, STAT1, STAT2
19
Hide members
9.3CCL2, IFNB1, STAT2, STAT1, TYK2
20
Hide members
9.1CCL2, IFNB1, STAT2, STAT1, TYK2, FURIN

Compounds for genes affiliated with Venezuelan Equine Encephalitis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1mumps4410.4STAT2, STAT1
2vanadate4410.2STAT2, STAT1, TYK2
3mdms4410.0STAT1, CCL2
42,5-oligoadenylate4410.0STAT1, STAT2, IFNB1
5estrogen4410.0BCAR3, FURIN
6serine4410.0CCL2, STAT2, STAT1, FURIN
7ifn-alpha449.9TYK2, STAT1, STAT2, IFNB1
8tetracycline44 1110.8CCL2, IFNB1, SAT1, FURIN
9mannose 6-phosphate44 2410.7FURIN, RAB7A, RAB5A
10sb 20358044 5910.7STAT1, SAT1, IFNB1, CCL2
11wortmannin449.7CCL2, STAT1, TYK2, RAB5A, LGALS3
12matrigel449.6RPSA, STAT1, IL32, LGALS3
13hcec449.5IFNB1, CCL2
14cisplatin44 49 59 1112.5CCL2, IFNB1, SAT1, STAT1, LGALS3
15superoxide44 2410.5CCL2, IFNB1, STAT1, LGALS3, FURIN
16ly294002449.5CCL2, IFNB1, STAT1, TYK2
17etoposide44 49 59 1112.5LGALS3, STAT1, IFNB1, RPSA
18h2o2449.5IFNB1, SAT1, STAT1, TYK2, LGALS3
19phosphatidylinositol449.4CCL2, STAT1, TYK2, RAB5A, RAB7A, LGALS3
20actinomycin d449.3CCL2, IFNB1, SAT1, STAT1
21cholesterol44 28 11 2412.3CCL2, IFNB1, STAT1, RAB7A, FURIN
22progesterone44 59 28 11 2413.2RPSA, IFNB1, STAT1, LGALS3, FURIN
23glucose449.0CCL2, IFNB1, SAT1, STAT1, RAB5A, FURIN
24cysteine448.8RPSA, IFNB1, STAT1, RAB5A, LGALS3, FURIN
25tyrosine448.8IFNB1, STAT2, STAT1, TYK2, IL32, RAB5A
26lipid448.6RPSA, CCL2, IFNB1, STAT1, RAB5A, RAB7A

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascadeGO:0072599.8STAT1, STAT2, CCL2
2regulation of type I interferon-mediated signaling pathwayGO:0603389.6TYK2, STAT1, STAT2, IFNB1
3type I interferon-mediated signaling pathwayGO:0603379.6IFNB1, STAT2, STAT1, TYK2
4cytokine-mediated signaling pathwayGO:0192219.3CCL2, IFNB1, STAT2, STAT1, TYK2
5defense response to virusGO:0516079.2DDX60, STAT1, STAT2, IFNB1
6small GTPase mediated signal transductionGO:0072648.3SH2D3A, SH2D3C, RAB5A, RAB7A, BCAR3

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanyl-nucleotide exchange factor activityGO:0050859.2BCAR3, SH2D3C, SH2D3A

Products for genes affiliated with Venezuelan Equine Encephalitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venezuelan Equine Encephalitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet