MCID: VNZ002
MIFTS: 43

Venezuelan Equine Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

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Aliases & Descriptions for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 10 45 12
Encephalomyelitis, Venezuelan Equine 36
Venezuelan Equine Encephalomyelitis 65
 
Encephalitis Venezuelan Equine 47
Venezuelan Equine Fever 10

Classifications:



External Ids:

Disease Ontology10 DOID:9584
ICD1027 A92.2
ICD9CM29 066.2
MeSH36 D004685
NCIt42 C35121
UMLS65 C0014078

Summaries for Venezuelan Equine Encephalitis

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Disease Ontology:10 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary: Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to encephalitis and vaccinia, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways are IL6-mediated signaling events and Interferon Pathway. Affiliated tissues include brain of horses, brain and t cells, and related mouse phenotype hematopoietic system.

Related Diseases for Venezuelan Equine Encephalitis

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Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis27.9ERF, IL32, LGALS3, RPSA, SAT1, STAT1
2vaccinia10.3
3chikungunya10.2
4tick-borne encephalitis10.2
5eastern equine encephalitis10.2
6st. louis encephalitis10.1
7neuronitis10.1
8hiv-110.0
9hepatitis10.0
10mumps10.0
11western equine encephalitis10.0
12japanese encephalitis10.0
13lyme disease10.0
14rift valley fever10.0
15cerebritis10.0
16mouth disease10.0
17ebola hemorrhagic fever10.0
18influenza10.0
19herpes simplex10.0
20cowpox10.0
21stomatitis10.0
22yellow fever10.0
23hemorrhagic fever10.0
24hairy cell leukemia of spleen9.7STAT1, STAT2
25hodgkin's lymphoma, lymphocytic depletion9.7STAT1, STAT2
26ornithosis9.6STAT1, STAT2
27dentin dysplasia9.4STAT1, STAT2

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Symptoms for Venezuelan Equine Encephalitis

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Symptoms:

 10
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

Drugs & Therapeutics for Venezuelan Equine Encephalitis

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Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 2, Phase 16085
2Immunologic FactorsPhase 118483
3MitogensPhase 11386

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis VaccineEnrolling by invitationNCT00582504Phase 2
2Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83SuspendedNCT00582088Phase 2
3Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy VolunteersCompletedNCT01984983Phase 1
4A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901Active, not recruitingNCT01526473Phase 1
5Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus VaccineWithdrawnNCT00109304Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis


Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

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Anatomical Context for Venezuelan Equine Encephalitis

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MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

33
Brain, T cells, Thyroid, Breast, Endothelial, Prostate, Skin

FMA organs/tissues related to Venezuelan Equine Encephalitis:

16
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6ERF, LGALS3, RPSA, STAT1, STAT2

Publications for Venezuelan Equine Encephalitis

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Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. (27129427)
2016
2
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. (26792742)
2016
3
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. (27030368)
2016
4
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. (27105216)
2016
5
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. (26168898)
2015
6
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. (25908124)
2015
7
NMR study of non-structural proteins-part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). (25291978)
2014
8
Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus. (23988697)
2013
9
Specific detection of all members of the Venezuelan Equine Encephalitis complex: development of a RT-Nested PCR. (22609888)
2012
10
Venezuelan equine encephalitis in a teenager visiting Central America. (22472656)
2012
11
Infected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particles. (22531556)
2012
12
First detection of Rio Negro virus (Venezuelan equine encephalitis complex subtype VI) in CA^rdoba, Argentina. (22310545)
2012
13
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
14
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV) (24479198)
2010
15
T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody. (20181704)
2010
16
Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection. (19264673)
2009
17
Isolation and phylogenetic analysis of Mucambo virus (Venezuelan equine encephalitis complex subtype IIIA) in Trinidad. (19631956)
2009
18
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
19
Vector competence of eastern and western forms of Psorophora columbiae (Diptera: Culicidae) mosquitoes for enzootic and epizootic Venezuelan equine encephalitis virus. (18337337)
2008
20
Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells. (17292936)
2007
21
Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity and efficacy in horses. (17240002)
2007
22
Purification, crystallization and X-ray diffraction analysis of the C-terminal protease domain of Venezuelan equine encephalitis virus nsP2. (16754969)
2006
23
Determining functionally important amino acid residues of the E1 protein of Venezuelan equine encephalitis virus. (16607494)
2006
24
Venezuelan equine encephalitis virus entry mechanism requires late endosome formation and resists cell membrane cholesterol depletion. (16427678)
2006
25
Postepizootic persistence of Venezuelan equine encephalitis virus, Venezuela. (16485478)
2005
26
Ecological characterization of the aquatic habitats of mosquitoes (Diptera: Culicidae) in enzootic foci of Venezuelan equine encephalitis virus in western Venezuela. (15962775)
2005
27
Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus. (15251409)
2004
28
Susceptibility of Ochlerotatus taeniorhynchus (Diptera: Culicidae) to infection with epizootic (subtype IC) and enzootic (subtype ID) Venezuelan equine encephalitis viruses: evidence for epizootic strain adaptation. (15535633)
2004
29
Immune protection against staphylococcal enterotoxin-induced toxic shock by vaccination with a Venezuelan equine encephalitis virus replicon. (11930333)
2002
30
Vector infection determinants of Venezuelan equine encephalitis virus reside within the E2 envelope glycoprotein. (12021373)
2002
31
Short report: Isolation and identification of Venezuelan equine encephalitis virus from a human in Panama. (12363053)
2002
32
Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection. (10208925)
1999
33
Limited potential for mosquito transmission of genetically engineered, live-attenuated Venezuelan equine encephalitis virus vaccine candidates. (10403340)
1999
34
Effect of salt concentration in larval rearing water on susceptibility of Aedes Mosquitoes (Diptera: Culicidae) to eastern equine and Venezuelan equine encephalitis viruses. (9775590)
1998
35
Nucleotide sequences of the 26S mRNAs of the viruses defining the Venezuelan equine encephalitis antigenic complex. (9886206)
1998
36
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
37
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
38
Apoptotic cell death is an important cause of neuronal injury in experimental Venezuelan equine encephalitis virus infection of mice. (9113200)
1997
39
Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. (7777497)
1995
40
Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus. (8085379)
1994
41
Molecular evidence that epizootic Venezuelan equine encephalitis (VEE) I-AB viruses are not evolutionary derivatives of enzootic VEE subtype I-E or II viruses. (8445371)
1993
42
Genetic variation of Venezuelan equine encephalitis virus strains of the ID variety in Colombia. (3341520)
1988
43
Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. (3184276)
1988
44
Central nervous system alterations as sequelae of Venezuelan equine encephalitis virus infection in the rat. (469656)
1979
45
Production of Venezuelan equine encephalitis virus in cells grown on artificial capillaries. (637540)
1978
46
Human Venezuelan equine encephalitis virus infection in Florida. (4823800)
1974
47
Experimental infection and intracage transmission of Venezuelan equine encephalitis virus (subtype IB) among cotton rats, Sigmodon hispidus (Say and Ord). (4429187)
1974
48
Alterations in immune responses by attenuated Venezuelan equine encephalitis vaccine. II. Pathology and soluble antigen localization in guinea pigs. (4890323)
1969
49
Ecology of Venezuelan equine encephalitis virus in Panama. (4904962)
1969
50
Epidemiological aspects of venezuelan equine encephalitis virus infections. (16350203)
1967

Variations for Venezuelan Equine Encephalitis

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Expression for genes affiliated with Venezuelan Equine Encephalitis

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Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

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GO Terms for genes affiliated with Venezuelan Equine Encephalitis

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Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:00603389.8STAT1, STAT2
2defense response to virusGO:00516079.4STAT1, STAT2

Sources for Venezuelan Equine Encephalitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet