MCID: VNZ002
MIFTS: 52

Venezuelan Equine Encephalitis malady

Summaries for Venezuelan Equine Encephalitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in venezuelan equine encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards: Venezuelan Equine Encephalitis, also known as venezuelan equine encephalomyelitis, is related to encephalitis and eastern equine encephalitis, and has symptoms including myalgia in the legs, severe headache and malaise. An important gene associated with Venezuelan Equine Encephalitis is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are IL-22 Pathway and IL27-mediated signaling events. The compounds mumps and vanadate have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, brain and t cells, and related mouse phenotypes are normal and cellular.

Wikipedia:63 Venezuelan equine encephalitis virus is a mosquito-borne viral pathogen that causes Venezuelan equine... more...

Aliases & Classifications for Venezuelan Equine Encephalitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

venezuelan equine encephalitis 8 42 10
venezuelan equine encephalomyelitis 60
encephalitis venezuelan equine 44


External Ids:

Disease Ontology8 DOID:9584
ICD9CM27 066.2
MeSH34 D004685
NCIt39 C35121

Related Diseases for Venezuelan Equine Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.3CCL2
2eastern equine encephalitis31.0SH2D3C
3vaccinia30.9FURIN
4chikungunya30.6SH2D3C, SH2D3A
5yellow fever30.4PRNT
6mumps30.4STAT2, STAT1
7hepatitis30.4STAT1, IFNB1
8influenza30.4STAT1, IFNB1, FURIN
9western equine encephalitis10.7
10viral encephalitis10.6
11tick-borne encephalitis10.5
12st. louis encephalitis10.4
13neuronitis10.4
14rift valley fever10.3
15cowpox10.3
16venezuelan hemorrhagic fever10.3
17ebola hemorrhagic fever10.3
18cerebritis10.3
19west nile fever10.3
20japanese encephalitis10.3
21lyme disease10.3
22hepatitis a10.3
23encephalomyelitis10.3
24herpes simplex10.3
25mouth disease10.3
26stomatitis10.3
27west nile encephalitis10.3
28severe acute respiratory syndrome10.0SH2D3C, SH2D3A
29myeloid leukemia10.0STAT1, STAT2
30chronic inflammatory demyelinating polyradiculoneuropathy10.0IFNB1
31hepatocellular carcinoma10.0IL32, IFNB1
32glioblastoma multiforme10.0STAT1, LGALS3
33myeloma10.0TYK2, STAT1
34measles10.0STAT1, IFNB1
35hepatitis c10.0TYK2, STAT1, IFNB1
36fibrosarcoma10.0STAT2, IFNB1, TYK2, STAT1
37prostate cancer10.0TYK2, STAT1, LGALS3, IL32
38sarcoidosis10.0CCL2, STAT1
39tuberculosis10.0STAT2, STAT1, IFNB1, RAB5A
40ovarian cancer10.0SAT1, IFNB1, RPSA, FURIN
41leukemia10.0STAT1, SAT1, IFNB1, ERF, TYK2
42colon cancer10.0TYK2, FURIN, IFNB1, LGALS3, STAT1
43allergic asthma10.0CCL2, STAT1, IFNB1
44arthritis10.0CCL2, STAT1, IL32
45malignant glioma10.0IFNB1, STAT1, IL32, LGALS3, FURIN
46systemic lupus erythematosus10.0CCL2, TYK2, STAT1, IFNB1
47multiple sclerosis10.0STAT1, IFNB1, CCL2
48rheumatoid arthritis10.0CCL2, IFNB1, TYK2, IL32, STAT1
49melanoma10.0RPSA, IFNB1, LGALS3, STAT1, STAT2, SAT1
50burkitt's lymphoma10.0FURIN, LGALS3, TYK2, STAT1, RPSA

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Clinical Features for Venezuelan Equine Encephalitis

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8Disease Ontology
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Symptoms:

8
  • myalgia in the legs
  • severe headache
  • malaise
  • chills
  • fever
  • photophobia

Drugs & Therapeutics for Venezuelan Equine Encephalitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Venezuelan Equine Encephalitis

Drug clinical trials:

Search ClinicalTrials for Venezuelan Equine Encephalitis

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Search CenterWatch for Venezuelan Equine Encephalitis

Genetic Tests for Venezuelan Equine Encephalitis

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Anatomical Context for Venezuelan Equine Encephalitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

32
Brain, T cells, Pancreas, Myeloid, Spleen, Kidney, Olfactory bulb, Testes

FMA organs/tissues related to Venezuelan Equine Encephalitis:

14
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4CCL2, IFNB1, SAT1, STAT1, RAB7A, ERF
2MP:00053848.2IFNB1, SAT1, STAT2, STAT1, SH2D3C, TYK2
3MP:00053977.9LGALS3, RPSA, CCL2, IFNB1, STAT2, STAT1

Publications for Venezuelan Equine Encephalitis

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50PubMed
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Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Specific detection of all members of the Venezuelan Equine Encephalitis complex: development of a RT-Nested PCR. (22609888)
2012
2
Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice. (22525795)
2012
3
Safety and protective efficacy of INA-inactivated Venezuelan equine encephalitis virus: implication in vaccine development. (21115048)
2011
4
Differential accumulation of genetic and phenotypic changes in Venezuelan equine encephalitis virus and Japanese encephalitis virus following passage in vitro and in vivo. (21507450)
2011
5
Venezuelan equine Encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function. (20147401)
2010
6
Isolation and phylogenetic analysis of Mucambo virus (Venezuelan equine encephalitis complex subtype IIIA) in Trinidad. (19631956)
2009
7
Genetic variability and heterogeneity of Venezuelan equine encephalitis virus vector Ochlerotatus taeniorhynchus (Diptera: Culicidae) populations of the Colombian Atlantic coast, based on microsatellite loci. (19866436)
2009
8
Development of a novel monoclonal antibody with reactivity to a wide range of Venezuelan equine encephalitis virus strains. (19925641)
2009
9
Structural and functional elements of the promoter encoded by the 5' untranslated region of the Venezuelan equine encephalitis virus genome. (19515761)
2009
10
Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccine. (19406186)
2009
11
Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine. (18675850)
2008
12
Humanization and mammalian expression of a murine monoclonal antibody against Venezuelan equine encephalitis virus. (17289226)
2007
13
Purification, crystallization and X-ray diffraction analysis of the C-terminal protease domain of Venezuelan equine encephalitis virus nsP2. (16754969)
2006
14
Venezuelan equine encephalitis virus transmission and effect on pathogenesis. (16965696)
2006
15
Comparison of immune responses to gonococcal PorB delivered as outer membrane vesicles, recombinant protein, or Venezuelan equine encephalitis virus replicon particles. (16239559)
2005
16
Evaluation of methods to assess transmission potential of Venezuelan equine encephalitis virus by mosquitoes and estimation of mosquito saliva titers. (16014828)
2005
17
Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic. (12915543)
2003
18
Cytotoxic T-cell activity is not detectable in Venezuelan equine encephalitis virus-infected mice. (12573505)
2003
19
Candidate vaccine against botulinum neurotoxin serotype A derived from a Venezuelan equine encephalitis virus vector system. (11500447)
2001
20
Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains. (11504410)
2001
21
Comparison of dissociation-enhanced lanthanide fluorescent immunoassays to enzyme-linked immunosorbent assays for detection of staphylococcal enterotoxin B, Yersinia pestis-specific F1 antigen, and Venezuelan equine encephalitis virus. (11687442)
2001
22
Immunopathogenesis and immune modulation of Venezuelan equine encephalitis virus-induced disease in the mouse. (11384219)
2001
23
Potential sources of the 1995 Venezuelan equine encephalitis subtype IC epidemic. (11390583)
2001
24
Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated region. (11264360)
2001
25
Early expression of IFN-alpha/beta and iNOS in the brains of Venezuelan equine encephalitis virus-infected mice. (10714557)
2000
26
Improved mucosal protection against Venezuelan equine encephalitis virus is induced by the molecularly defined, live-attenuated V3526 vaccine candidate. (10825611)
2000
27
TC-83 vaccine protects against airborne or subcutaneous challenge with heterologous mouse-virulent strains of Venezuelan equine encephalitis virus. (10067707)
1999
28
Expression, processing, and immunogenicity of the structural proteins of Venezuelan equine encephalitis virus from recombinant baculovirus vectors. (10195627)
1999
29
Genetic evidence for the origins of Venezuelan equine encephalitis virus subtype IAB outbreaks. (10466974)
1999
30
Nucleotide sequences of the 26S mRNAs of the viruses defining the Venezuelan equine encephalitis antigenic complex. (9886206)
1998
31
Repeated emergence of epidemic/epizootic Venezuelan equine encephalitis from a single genotype of enzootic subtype ID virus. (9261393)
1997
32
Nonvascular delivery of St. Louis encephalitis and Venezuelan equine encephalitis viruses by infected mosquitoes (Diptera: Culicidae) feeding on a vertebrate host. (7650720)
1995
33
Molecular evidence that epizootic Venezuelan equine encephalitis (VEE) I-AB viruses are not evolutionary derivatives of enzootic VEE subtype I-E or II viruses. (8445371)
1993
34
Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: construction of single and multiple mutants in a full-length cDNA clone. (2053280)
1991
35
Selection for accelerated penetration in cell culture coselects for attenuated mutants of Venezuelan equine encephalitis virus. (3341117)
1988
36
Venezuelan equine encephalitis virus activity in northern Colombia during April and May 1983. (2879583)
1986
37
Congenital cerebral and ocular malformations induced in rhesus monkeys by Venezuelan equine encephalitis virus. (413204)
1977
38
Specific in vitro lymphocyte transformation with Venezuelan equine encephalitis virus. (57835)
1976
39
An evaluation of military sentry dogs as a sentinel system to everglades virus (Venezuelan equine encephalitis Fe3-7C strain). (812018)
1975
40
Epidemic Venezuelan equine encephalitis in North America in 1971: vertebrate field studies. (1119481)
1975
41
Features of cross protection between Sindbis and Venezuelan equine encephalitis viruses in mice--relationship of route of immunization to protection. (4427105)
1974
42
Venezuelan equine encephalitis. (4609399)
1974
43
Ecology of Venezuelan equine encephalitis virus in Panama. (4904962)
1969
44
Structural constituents of Venezuelan equine encephalitis virus. (4981664)
1969
45
Investigations of an outbreak of Venezuelan equine encephalitis in towns of eastern Venezuela. (4387218)
1968
46
Susceptibility of white Carneau pigeons to respiratory infection by Venezuelan equine encephalitis virus. (5910220)
1966
47
Infection of pigeons by airborne Venezuelan equine encephalitis virus. (5917338)
1966
48
Studies of the response of white Carneau pigeons to respiratory and subcutaneous doses of Venezuelan equine encephalitis virus. (5917605)
1966
49
INVESTIGATIONS DURING VENEZUELAN EQUINE ENCEPHALITIS OUTBREAKS IN VENEZUELA--1962-1964. (14292754)
1965
50
VENEZUELAN EQUINE ENCEPHALITIS VIRUS IN VERACRUZ, MEXICO, AND THE USE OF HAMSTERS AS SENTINELS. (14171568)
1964

Genetic Variations for Venezuelan Equine Encephalitis

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Expression for genes affiliated with Venezuelan Equine Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

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51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2, STAT1
2
Hide members
9.9STAT2, STAT1, TYK2
39.9TYK2, STAT1, STAT2
4
Hide members
9.9TYK2, STAT1, STAT2
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.9TYK2, STAT1, STAT2
6
Hide members
9.9STAT1, TYK2, RAB7A
79.9RAB7A, IFNB1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.8CCL2, STAT1, TYK2
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.8TYK2, STAT1, CCL2
109.7IFNB1, STAT2, STAT1
119.5TYK2, STAT1, STAT2, IFNB1
129.5TYK2, STAT1, STAT2, IFNB1
139.5IFNB1, STAT2, STAT1, TYK2
14
Immune response IFN alpha/beta signaling pathway
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
159.5IFNB1, STAT2, STAT1, TYK2
16
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
17
Hide members
9.4STAT1, STAT2, IFNB1, CCL2
189.4RAB5A, SH2D3C, STAT1, STAT2
19
Hide members
9.3CCL2, IFNB1, STAT2, STAT1, TYK2
20
Hide members
9.1CCL2, IFNB1, STAT2, STAT1, TYK2, FURIN

Compounds for genes affiliated with Venezuelan Equine Encephalitis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1mumps4410.4STAT2, STAT1
2vanadate4410.2STAT2, STAT1, TYK2
3mdms4410.0STAT1, CCL2
42,5-oligoadenylate4410.0STAT1, STAT2, IFNB1
5estrogen4410.0BCAR3, FURIN
6serine4410.0CCL2, STAT2, STAT1, FURIN
7ifn-alpha449.9TYK2, STAT1, STAT2, IFNB1
8tetracycline44 1110.8CCL2, IFNB1, SAT1, FURIN
9mannose 6-phosphate44 2410.7FURIN, RAB7A, RAB5A
10sb 20358044 5910.7STAT1, SAT1, IFNB1, CCL2
11wortmannin449.7CCL2, STAT1, TYK2, RAB5A, LGALS3
12matrigel449.6RPSA, STAT1, IL32, LGALS3
13hcec449.5IFNB1, CCL2
14cisplatin44 49 59 1112.5CCL2, IFNB1, SAT1, STAT1, LGALS3
15superoxide44 2410.5CCL2, IFNB1, STAT1, LGALS3, FURIN
16ly294002449.5CCL2, IFNB1, STAT1, TYK2
17etoposide44 49 59 1112.5LGALS3, STAT1, IFNB1, RPSA
18h2o2449.5IFNB1, SAT1, STAT1, TYK2, LGALS3
19phosphatidylinositol449.4CCL2, STAT1, TYK2, RAB5A, RAB7A, LGALS3
20actinomycin d449.3CCL2, IFNB1, SAT1, STAT1
21cholesterol44 28 11 2412.3CCL2, IFNB1, STAT1, RAB7A, FURIN
22progesterone44 59 28 11 2413.2RPSA, IFNB1, STAT1, LGALS3, FURIN
23glucose449.0CCL2, IFNB1, SAT1, STAT1, RAB5A, FURIN
24cysteine448.8RPSA, IFNB1, STAT1, RAB5A, LGALS3, FURIN
25tyrosine448.8IFNB1, STAT2, STAT1, TYK2, IL32, RAB5A
26lipid448.6RPSA, CCL2, IFNB1, STAT1, RAB5A, RAB7A

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

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16Gene Ontology
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Biological processes related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascadeGO:0072599.8STAT2, CCL2, STAT1
2regulation of type I interferon-mediated signaling pathwayGO:0603389.6IFNB1, STAT2, STAT1, TYK2
3type I interferon-mediated signaling pathwayGO:0603379.6TYK2, STAT1, STAT2, IFNB1
4cytokine-mediated signaling pathwayGO:0192219.3CCL2, IFNB1, STAT2, STAT1, TYK2
5defense response to virusGO:0516079.2IFNB1, STAT2, STAT1, DDX60
6small GTPase mediated signal transductionGO:0072648.3SH2D3A, RAB5A, RAB7A, BCAR3, SH2D3C

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanyl-nucleotide exchange factor activityGO:0050859.2BCAR3, SH2D3C, SH2D3A

Products for genes affiliated with Venezuelan Equine Encephalitis

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Sources for Venezuelan Equine Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet