MCID: VNZ002
MIFTS: 44

Venezuelan Equine Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

About this section

Aliases & Descriptions for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 11 47 13
Encephalomyelitis, Venezuelan Equine 38
Venezuelan Equine Encephalomyelitis 67
 
Encephalitis Venezuelan Equine 49
Venezuelan Equine Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:9584
ICD1029 A92.2
ICD9CM31 066.2
MeSH38 D004685
NCIt44 C35121

Summaries for Venezuelan Equine Encephalitis

About this section
Disease Ontology:11 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary: Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to encephalitis and vaccinia, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways are Regulation of nuclear SMAD2/3 signaling and Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics. Affiliated tissues include brain of horses, brain and t cells, and related mouse phenotypes are hematopoietic system and neoplasm.

Related Diseases for Venezuelan Equine Encephalitis

About this section

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis11.2
2vaccinia10.2
3chikungunya10.1
4tick-borne encephalitis10.1
5eastern equine encephalitis10.1
6st. louis encephalitis10.0
7neuronitis10.0
8hiv-19.9
9hepatitis9.9
10mumps9.9
11western equine encephalitis9.9
12japanese encephalitis9.9
13lyme disease9.9
14rift valley fever9.9
15cerebritis9.9
16mouth disease9.9
17ebola hemorrhagic fever9.9
18influenza9.9
19herpes simplex9.9
20cowpox9.9
21stomatitis9.9
22yellow fever9.9
23hemorrhagic fever9.9
24holoprosencephaly-79.5IRF1, STAT1
25optic nerve disease9.1IFNB1, IRF7, STAT1
26urethral calculus7.6IFNB1, IL32, IRF1, IRF7, RPSA, SAT1

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Symptoms for Venezuelan Equine Encephalitis

About this section

Symptoms:

 11 (show all 6)
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

Drugs & Therapeutics for Venezuelan Equine Encephalitis

About this section

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 2, Phase 16428
2MitogensPhase 11526

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis VaccineEnrolling by invitationNCT00582504Phase 2
2Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83SuspendedNCT00582088Phase 2
3Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy VolunteersCompletedNCT01984983Phase 1
4A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901Active, not recruitingNCT01526473Phase 1
5Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus VaccineWithdrawnNCT00109304Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis


Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

About this section

Anatomical Context for Venezuelan Equine Encephalitis

About this section

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

35
Brain, T cells, Myeloid, Testes, Olfactory bulb, Pancreas, Spleen

FMA organs/tissues related to Venezuelan Equine Encephalitis:

17
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IFNB1, IRF1, IRF7, LGALS3, RPSA, STAT1
2MP:00020067.6IFNB1, IRF1, LGALS3, SAT1, STAT1

Publications for Venezuelan Equine Encephalitis

About this section

Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 428)
idTitleAuthorsYear
1
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. (27030368)
2016
2
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. (27105216)
2016
3
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. (27318152)
2016
4
The role of IKKI^ in Venezuelan equine encephalitis virus infection. (24586253)
2014
5
Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. (24125177)
2014
6
Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus. (23988697)
2013
7
Venezuelan equine encephalitis in a teenager visiting Central America. (22472656)
2012
8
Infected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particles. (22531556)
2012
9
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
10
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV) (24479198)
2010
11
T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody. (20181704)
2010
12
Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein. (20668087)
2010
13
Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system. (21050901)
2010
14
Vector competence of Culex (Melanoconion) taeniopus for equine-virulent subtype IE strains of Venezuelan equine encephalitis virus. (20519599)
2010
15
Genetic variability and heterogeneity of Venezuelan equine encephalitis virus vector Ochlerotatus taeniorhynchus (Diptera: Culicidae) populations of the Colombian Atlantic coast, based on microsatellite loci. (19866436)
2009
16
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
17
Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity and efficacy in horses. (17240002)
2007
18
Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription. (17913819)
2007
19
Humanization and mammalian expression of a murine monoclonal antibody against Venezuelan equine encephalitis virus. (17289226)
2007
20
Vaccination of mice with gonococcal TbpB expressed in vivo from Venezuelan equine encephalitis viral replicon particles. (16495532)
2006
21
Postepizootic persistence of Venezuelan equine encephalitis virus, Venezuela. (16485478)
2005
22
Ecological characterization of the aquatic habitats of mosquitoes (Diptera: Culicidae) in enzootic foci of Venezuelan equine encephalitis virus in western Venezuela. (15962775)
2005
23
A novel, rapid assay for detection and differentiation of serotype-specific antibodies to Venezuelan equine encephalitis complex alphaviruses. (15964967)
2005
24
Venezuelan equine encephalitis. (14651460)
2004
25
Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes. (14670335)
2004
26
An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector. (12970424)
2003
27
Immune protection against staphylococcal enterotoxin-induced toxic shock by vaccination with a Venezuelan equine encephalitis virus replicon. (11930333)
2002
28
Candidate vaccine against botulinum neurotoxin serotype A derived from a Venezuelan equine encephalitis virus vector system. (11500447)
2001
29
Comparative neurovirulence of attenuated and non-attenuated strains of Venezuelan equine encephalitis virus in mice. (11425162)
2001
30
Ecological studies of enzootic Venezuelan equine encephalitis in north-central Venezuela, 1997-1998. (11425168)
2001
31
Role of dendritic cell targeting in Venezuelan equine encephalitis virus pathogenesis. (10623754)
2000
32
Limited potential for mosquito transmission of genetically engineered, live-attenuated Venezuelan equine encephalitis virus vaccine candidates. (10403340)
1999
33
Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan Equine Encephalitis virus. (10547416)
1999
34
Nucleotide sequences of the 26S mRNAs of the viruses defining the Venezuelan equine encephalitis antigenic complex. (9886206)
1998
35
Venezuelan equine encephalitis febrile cases among humans in the Peruvian Amazon River region. (9452289)
1998
36
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
37
Apoptotic cell death is an important cause of neuronal injury in experimental Venezuelan equine encephalitis virus infection of mice. (9113200)
1997
38
Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. (7777497)
1995
39
Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. (7676619)
1995
40
Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus. (8085379)
1994
41
Molecular evidence that epizootic Venezuelan equine encephalitis (VEE) I-AB viruses are not evolutionary derivatives of enzootic VEE subtype I-E or II viruses. (8445371)
1993
42
Venezuelan equine encephalitis virus propagation in the olfactory tract of normal and immunized mice. (1841630)
1991
43
Protection against lethal Venezuelan equine encephalitis (VEE) virus infection by cell-free supernatant obtained from immune spleen cells. (1698216)
1990
44
Entomological studies at an enzootic Venezuelan equine encephalitis virus focus in Guatemala, 1977-1980. (2873752)
1986
45
Production of Venezuelan equine encephalitis virus in cells grown on artificial capillaries. (637540)
1978
46
An evaluation of military sentry dogs as a sentinel system to everglades virus (Venezuelan equine encephalitis Fe3-7C strain). (812018)
1975
47
Laboratory studies of Venezuelan equine encephalitis virus in equines, Texas, 1971. (1176627)
1975
48
Surveillance of Venezuelan equine encephalitis in the United States--1972. (4149690)
1973
49
Possible evidence for interference with Venezuelan equine encephalitis virus vaccination of equines by pre-existing antibody to Eastern or Western Equine encephalitis virus, or both. (4751797)
1973
50
Alterations in immune responses by attenuated Venezuelan equine encephalitis vaccine. II. Pathology and soluble antigen localization in guinea pigs. (4890323)
1969

Variations for Venezuelan Equine Encephalitis

About this section

Expression for genes affiliated with Venezuelan Equine Encephalitis

About this section
Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

About this section

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNB1, IRF7
2
Show member pathways
9.3IRF7, STAT1
39.1IFNB1, STAT1
49.1LGALS3, STAT1
59.0IRF1, STAT1
6
Show member pathways
9.0IRF1, STAT1
7
Show member pathways
9.0IFNB1, IRF1, IRF7
89.0IFNB1, IRF1, IRF7
99.0IFNB1, IRF1, IRF7
10
Show member pathways
8.5IFNB1, IRF1, STAT1
118.5IFNB1, IRF1, STAT1
12
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
13
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
148.1IFNB1, IRF1, IRF7, STAT1
15
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
168.1IRF1, IRF7, LGALS3, STAT1
17
Show member pathways
7.2IFNB1, IL32, IRF1, IRF7, LGALS3, STAT1

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

About this section

Cellular components related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058297.4IL32, IRF1, IRF7, RPSA, SAT1, STAT1

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of MyD88-dependent toll-like receptor signaling pathwayGO:003412410.2IRF1, IRF7
2regulation of adaptive immune responseGO:000281910.0IRF1, IRF7
3positive regulation of interferon-beta productionGO:00327289.8IRF1, IRF7
4regulation of type I interferon-mediated signaling pathwayGO:00603389.7IFNB1, STAT1
5positive regulation of type I interferon productionGO:00324819.7IRF1, IRF7
6epithelial cell differentiationGO:00308559.5LGALS3, RPSA
7interferon-gamma-mediated signaling pathwayGO:00603339.2IRF1, IRF7, STAT1
8cellular response to interferon-betaGO:00354588.9IFNB1, IRF1, STAT1
9type I interferon signaling pathwayGO:00603378.7IFNB1, IRF1, IRF7, STAT1
10defense response to virusGO:00516078.6IFNB1, IRF1, STAT1
11positive regulation of transcription from RNA polymerase II promoterGO:00459448.1IFNB1, IRF1, IRF7, STAT1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1laminin bindingGO:00432369.6LGALS3, RPSA
2RNA polymerase II core promoter sequence-specific DNA bindingGO:00009799.0IRF7, STAT1

Sources for Venezuelan Equine Encephalitis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet