MCID: VNZ002
MIFTS: 38

Venezuelan Equine Encephalitis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Venezuelan Equine Encephalitis

About this section

Aliases & Descriptions for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 10 45 12
Encephalomyelitis, Venezuelan Equine 36
 
Venezuelan Equine Encephalomyelitis 65
Encephalitis Venezuelan Equine 47


Classifications:



External Ids:

Disease Ontology10 DOID:9584
NCIt42 C35121
ICD9CM29 066.2
MeSH36 D004685

Summaries for Venezuelan Equine Encephalitis

About this section
Disease Ontology:10 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in venezuelan equine encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary: Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to encephalitis and vaccinia, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways are IL6-mediated signaling events and . Affiliated tissues include brain of horses, brain and t cells.

Related Diseases for Venezuelan Equine Encephalitis

About this section

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis11.6
2vaccinia10.7
3tick-borne encephalitis10.6
4eastern equine encephalitis10.6
5neuronitis10.5
6chikungunya10.5
7st. louis encephalitis10.5
8viral encephalitis10.5
9viral infectious disease10.5
10togaviridae disease10.5
11hiv-110.3
12pick disease10.3
13pharyngitis10.3
14rift valley fever10.3
15mumps10.3
16lyme disease10.3
17yellow fever10.3
18ebola hemorrhagic fever10.3
19cerebritis10.3
20japanese encephalitis10.3
21western equine encephalitis10.3
22cowpox10.3
23herpes simplex10.3
24influenza10.3
25mouth disease10.3
26nose disease10.3
27specific developmental disorder10.3
28stomatitis10.3
29hemorrhagic fever10.3
30encephalopathy10.3
31vulva fibroepithelial polyp8.7IFNB1, IL32, IRF1, IRF7, LGALS3, RAB7A

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Symptoms for Venezuelan Equine Encephalitis

About this section

Symptoms:

 10
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

Drugs & Therapeutics for Venezuelan Equine Encephalitis

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis VaccineEnrolling by invitationNCT00582504Phase 2
2Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83SuspendedNCT00582088Phase 2
3Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy VolunteersCompletedNCT01984983Phase 1
4A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901Active, not recruitingNCT01526473Phase 1
5Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus VaccineWithdrawnNCT00109304Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis


Cochrane evidence based reviews: Encephalomyelitis, Venezuelan Equine

Genetic Tests for Venezuelan Equine Encephalitis

About this section

Anatomical Context for Venezuelan Equine Encephalitis

About this section

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

33
Brain, T cells, Olfactory bulb, Myeloid, Pancreas, Kidney, Spleen

FMA organs/tissues related to Venezuelan Equine Encephalitis:

16
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

About this section

Publications for Venezuelan Equine Encephalitis

About this section

Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 405)
idTitleAuthorsYear
1
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. (26168898)
2015
2
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. (25908124)
2015
3
NMR study of non-structural proteins-part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). (25291978)
2014
4
Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus. (23988697)
2013
5
Specific detection of all members of the Venezuelan Equine Encephalitis complex: development of a RT-Nested PCR. (22609888)
2012
6
Venezuelan equine encephalitis in a teenager visiting Central America. (22472656)
2012
7
Infected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particles. (22531556)
2012
8
First detection of Rio Negro virus (Venezuelan equine encephalitis complex subtype VI) in CA^rdoba, Argentina. (22310545)
2012
9
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
10
4.4 A8 cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. (21829169)
2011
11
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV) (24479198)
2010
12
T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody. (20181704)
2010
13
Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein. (20668087)
2010
14
Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection. (19264673)
2009
15
Isolation and phylogenetic analysis of Mucambo virus (Venezuelan equine encephalitis complex subtype IIIA) in Trinidad. (19631956)
2009
16
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
17
Vector competence of eastern and western forms of Psorophora columbiae (Diptera: Culicidae) mosquitoes for enzootic and epizootic Venezuelan equine encephalitis virus. (18337337)
2008
18
Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells. (17292936)
2007
19
Venezuelan equine encephalitis virus vaccine candidate (V3526) safety, immunogenicity and efficacy in horses. (17240002)
2007
20
Purification, crystallization and X-ray diffraction analysis of the C-terminal protease domain of Venezuelan equine encephalitis virus nsP2. (16754969)
2006
21
Determining functionally important amino acid residues of the E1 protein of Venezuelan equine encephalitis virus. (16607494)
2006
22
Venezuelan equine encephalitis virus entry mechanism requires late endosome formation and resists cell membrane cholesterol depletion. (16427678)
2006
23
Postepizootic persistence of Venezuelan equine encephalitis virus, Venezuela. (16485478)
2005
24
Ecological characterization of the aquatic habitats of mosquitoes (Diptera: Culicidae) in enzootic foci of Venezuelan equine encephalitis virus in western Venezuela. (15962775)
2005
25
Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus. (15251409)
2004
26
Susceptibility of Ochlerotatus taeniorhynchus (Diptera: Culicidae) to infection with epizootic (subtype IC) and enzootic (subtype ID) Venezuelan equine encephalitis viruses: evidence for epizootic strain adaptation. (15535633)
2004
27
Immune protection against staphylococcal enterotoxin-induced toxic shock by vaccination with a Venezuelan equine encephalitis virus replicon. (11930333)
2002
28
Vector infection determinants of Venezuelan equine encephalitis virus reside within the E2 envelope glycoprotein. (12021373)
2002
29
Short report: Isolation and identification of Venezuelan equine encephalitis virus from a human in Panama. (12363053)
2002
30
Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection. (10208925)
1999
31
Limited potential for mosquito transmission of genetically engineered, live-attenuated Venezuelan equine encephalitis virus vaccine candidates. (10403340)
1999
32
Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan Equine Encephalitis virus. (10547416)
1999
33
Effect of salt concentration in larval rearing water on susceptibility of Aedes Mosquitoes (Diptera: Culicidae) to eastern equine and Venezuelan equine encephalitis viruses. (9775590)
1998
34
Nucleotide sequences of the 26S mRNAs of the viruses defining the Venezuelan equine encephalitis antigenic complex. (9886206)
1998
35
Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. (9060663)
1997
36
Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo. (9434729)
1997
37
Apoptotic cell death is an important cause of neuronal injury in experimental Venezuelan equine encephalitis virus infection of mice. (9113200)
1997
38
Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. (7777497)
1995
39
Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus. (8085379)
1994
40
Molecular evidence that epizootic Venezuelan equine encephalitis (VEE) I-AB viruses are not evolutionary derivatives of enzootic VEE subtype I-E or II viruses. (8445371)
1993
41
Protection against lethal Venezuelan equine encephalitis (VEE) virus infection by cell-free supernatant obtained from immune spleen cells. (1698216)
1990
42
Genetic variation of Venezuelan equine encephalitis virus strains of the ID variety in Colombia. (3341520)
1988
43
Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. (3184276)
1988
44
Central nervous system alterations as sequelae of Venezuelan equine encephalitis virus infection in the rat. (469656)
1979
45
Production of Venezuelan equine encephalitis virus in cells grown on artificial capillaries. (637540)
1978
46
Human Venezuelan equine encephalitis virus infection in Florida. (4823800)
1974
47
Experimental infection and intracage transmission of Venezuelan equine encephalitis virus (subtype IB) among cotton rats, Sigmodon hispidus (Say and Ord). (4429187)
1974
48
Alterations in immune responses by attenuated Venezuelan equine encephalitis vaccine. II. Pathology and soluble antigen localization in guinea pigs. (4890323)
1969
49
Ecology of Venezuelan equine encephalitis virus in Panama. (4904962)
1969
50
Epidemiological aspects of venezuelan equine encephalitis virus infections. (16350203)
1967

Variations for Venezuelan Equine Encephalitis

About this section

Expression for genes affiliated with Venezuelan Equine Encephalitis

About this section
Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

About this section

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IRF1, RPSA
2
Salmonella infection (KEGG)
Show member pathways
9.6IRF1, RPSA
39.2IFNB1, IRF7
49.1IFNB1, IRF1
58.9IRF1, IRF7, LGALS3
6
Show member pathways
8.8IFNB1, IRF1, RPSA
78.8IFNB1, RAB7A, RPSA
8
Show member pathways
8.7IFNB1, IRF1, IRF7
9
Show member pathways
8.7IFNB1, IRF1, IRF7
108.7IFNB1, IRF1, IRF7
118.7IFNB1, IRF1, IRF7
12
Show member pathways
8.7IFNB1, IRF1, IRF7
138.7IFNB1, IRF1, IRF7
14
Show member pathways
7.2IFNB1, IRF1, IRF7, LGALS3, RAB7A, RPSA

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

About this section

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of adaptive immune responseGO:000281910.1IRF1, IRF7
2regulation of MyD88-dependent toll-like receptor signaling pathwayGO:003412410.1IRF1, IRF7
3positive regulation of interferon-beta productionGO:003272810.0IRF1, IRF7
4interferon-gamma-mediated signaling pathwayGO:00603339.9IRF1, IRF7
5cellular response to interferon-betaGO:00354589.6IFNB1, IRF1
6positive regulation of type I interferon productionGO:00324819.5IRF1, IRF7
7epithelial cell differentiationGO:00308559.5LGALS3, RPSA
8defense responseGO:00069529.3IFNB1, IL32
9type I interferon signaling pathwayGO:00603379.2IFNB1, IRF1, IRF7
10cytokine-mediated signaling pathwayGO:00192218.4IFNB1, IRF1, IRF7

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1laminin bindingGO:00432369.5LGALS3, RPSA
2regulatory region DNA bindingGO:00009759.4IRF1, IRF7

Sources for Venezuelan Equine Encephalitis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet