MCID: VNZ002
MIFTS: 50

Venezuelan Equine Encephalitis malady

Summaries for Venezuelan Equine Encephalitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in venezuelan equine encephalitis virus, which is transmitted by culex mosquitoes. the infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards: Venezuelan Equine Encephalitis, also known as venezuelan equine encephalomyelitis, is related to eastern equine encephalitis and vaccinia, and has symptoms including photophobia, fever and chills. An important gene associated with Venezuelan Equine Encephalitis is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are IL-22 Pathway and IL27-mediated signaling events. The compounds mumps and vanadate have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, brain and kidney, and related mouse phenotypes are normal and cellular.

Wikipedia:64 Venezuelan equine encephalitis virus is a mosquito-borne viral pathogen that causes Venezuelan equine... more...

Aliases & Classifications for Venezuelan Equine Encephalitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

venezuelan equine encephalitis 8 43 10
venezuelan equine encephalomyelitis 61
encephalitis venezuelan equine 45


External Ids:

Disease Ontology8 DOID:9584
ICD9CM27 066.2
MeSH35 D004685
NCIt40 C35121

Related Diseases for Venezuelan Equine Encephalitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1eastern equine encephalitis31.0SH2D3C
2vaccinia30.9FURIN
3chikungunya30.6SH2D3C, SH2D3A
4yellow fever30.4PRNT
5mumps30.4STAT2, STAT1
6western equine encephalitis10.7
7viral encephalitis10.6
8tick-borne encephalitis10.5
9rift valley fever10.3
10cowpox10.3
11venezuelan hemorrhagic fever10.3
12ebola hemorrhagic fever10.3
13west nile fever10.3
14japanese encephalitis10.3
15lyme disease10.3
16stomatitis10.3
17west nile encephalitis10.3
18nipah virus encephalitis10.3
19hemorrhagic fever10.3
20herpes simplex encephalitis10.3
21west nile virus10.3
22severe acute respiratory syndrome10.0SH2D3C, SH2D3A
23myeloid leukemia10.0STAT1, STAT2
24chronic inflammatory demyelinating polyradiculoneuropathy10.0IFNB1
25encephalitis10.0CCL2
26hepatocellular carcinoma10.0IL32, IFNB1
27glioblastoma multiforme10.0STAT1, LGALS3
28myeloma10.0TYK2, STAT1
29measles10.0STAT1, IFNB1
30hepatitis10.0STAT1, IFNB1
31hepatitis c10.0TYK2, STAT1, IFNB1
32influenza10.0STAT1, IFNB1, FURIN
33fibrosarcoma10.0STAT2, IFNB1, TYK2, STAT1
34prostate cancer10.0TYK2, STAT1, LGALS3, IL32
35sarcoidosis10.0CCL2, STAT1
36tuberculosis10.0STAT2, STAT1, IFNB1, RAB5A
37ovarian cancer10.0SAT1, IFNB1, RPSA, FURIN
38leukemia10.0STAT1, SAT1, IFNB1, ERF, TYK2
39colon cancer10.0TYK2, FURIN, IFNB1, LGALS3, STAT1
40allergic asthma10.0CCL2, STAT1, IFNB1
41arthritis10.0CCL2, STAT1, IL32
42malignant glioma10.0IFNB1, STAT1, IL32, LGALS3, FURIN
43systemic lupus erythematosus10.0CCL2, TYK2, STAT1, IFNB1
44multiple sclerosis10.0STAT1, IFNB1, CCL2
45rheumatoid arthritis10.0CCL2, IFNB1, TYK2, IL32, STAT1
46melanoma10.0RPSA, IFNB1, LGALS3, STAT1, STAT2, SAT1
47burkitt's lymphoma10.0FURIN, LGALS3, TYK2, STAT1, RPSA
48adenocarcinoma10.0RPSA, IFNB1, FURIN, LGALS3
49lung cancer10.0RPSA, STAT1, IFNB1, FURIN, SAT1
50viral infectious disease10.0IFNB1, STAT2, LGALS3, CCL2, STAT1, FURIN

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Clinical Features for Venezuelan Equine Encephalitis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 6)
  • photophobia
  • fever
  • chills
  • malaise
  • severe headache
  • myalgia in the legs

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Venezuelan Equine Encephalitis

Drug clinical trials:

Search ClinicalTrials for Venezuelan Equine Encephalitis

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Search CenterWatch for Venezuelan Equine Encephalitis

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

33
Brain, Kidney, Spleen, Pancreas, Myeloid, T cells, B cells, Fetal brain, Olfactory bulb

FMA organs/tissues related to Venezuelan Equine Encephalitis:

14
Brain of horses

Animal Models for Venezuelan Equine Encephalitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4CCL2, IFNB1, SAT1, STAT1, RAB7A, ERF
2MP:00053848.2IFNB1, SAT1, STAT2, STAT1, SH2D3C, TYK2
3MP:00053977.9LGALS3, RPSA, CCL2, IFNB1, STAT2, STAT1

Publications for Venezuelan Equine Encephalitis

Sources:
51PubMed
See all sources

Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Venezuelan Equine Encephalitis Viruses (VEEV) in Argentina: Serological Evidence of Human Infection. (24349588)
2013
2
Pathogenesis of Venezuelan equine encephalitis. (23968890)
2013
3
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus. (23408633)
2013
4
A humanised murine monoclonal antibody protects mice from Venezuelan equine encephalitis virus, Everglades virus and Mucambo virus when administered up to 48 h after airborne challenge. (22341308)
2012
5
Modulation of GSK-3I^ activity in Venezuelan equine encephalitis virus infection. (22496857)
2012
6
Host responses to live-attenuated Venezuelan equine encephalitis virus (TC-83): comparison of naA^ve, vaccine responder and nonresponder to TC-83 challenge in human peripheral blood mononuclear cells. (22617845)
2012
7
Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. (21715498)
2011
8
A recombinant humanized monoclonal antibody completely protects mice against lethal challenge with Venezuelan equine encephalitis virus. (20600509)
2010
9
Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates. (20851089)
2010
10
Venezuelan equine encephalitis and 2 human deaths, Peru. (20202445)
2010
11
Molecular insight into the specific binding of ADP-ribose to the nsP3 macro domains of chikungunya and Venezuelan equine encephalitis viruses: molecular dynamics simulations and free energy calculations. (21036084)
2010
12
Improved efficacy of a gene optimised adenovirus-based vaccine for venezuelan equine encephalitis virus. (19646224)
2009
13
Venezuelan equine encephalitis in Panama: fatal endemic disease and genetic diversity of etiologic viral strains. (19564908)
2009
14
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. (18501401)
2008
15
Protection of hamsters by Venezuelan equine encephalitis virus candidate vaccine V3526 against lethal challenge by mosquito bite and intraperitoneal injection. (18256440)
2008
16
Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in Mammalian but not in mosquito cells. (18256144)
2008
17
Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies. (18187789)
2008
18
Analysis of Venezuelan equine encephalitis replicon particles packaged in different coats. (18628938)
2008
19
Neurovirulence evaluation of Venezuelan equine encephalitis (VEE) vaccine candidate V3526 in nonhuman primates. (18508163)
2008
20
Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. (17292434)
2007
21
Complete inactivation of Venezuelan equine encephalitis virus by 1,5-iodonaphthylazide. (17493582)
2007
22
Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine. (17913817)
2007
23
Venezuelan equine encephalitis virus entry mechanism requires late endosome formation and resists cell membrane cholesterol depletion. (16427678)
2006
24
Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus. (17038698)
2006
25
Vaccination of macaques with SIV immunogens delivered by Venezuelan equine encephalitis virus replicon particle vectors followed by a mucosal challenge with SIVsmE660. (16005121)
2005
26
Susceptibility of Ochlerotatus taeniorhynchus (Diptera: Culicidae) to infection with epizootic (subtype IC) and enzootic (subtype ID) Venezuelan equine encephalitis viruses: evidence for epizootic strain adaptation. (15535633)
2004
27
Functional enhancement of a partially active single-chain variable fragment antibody to Venezuelan equine encephalitis virus. (12828872)
2003
28
Evaluation of Venezuelan Equine Encephalitis (VEE) replicon-based Outer surface protein A (OspA) vaccines in a tick challenge mouse model of Lyme disease. (12922122)
2003
29
Contrasting sylvatic foci of Venezuelan equine encephalitis virus in northern South America. (12408676)
2002
30
Combined effects of Venezuelan equine encephalitis IIIA virus and gamma irradiation in mice. (11778450)
2001
31
Role of dendritic cell targeting in Venezuelan equine encephalitis virus pathogenesis. (10623754)
2000
32
Identification and genetic analysis of Panama-genotype Venezuelan equine encephalitis virus subtype ID in Peru. (9452290)
1998
33
Venezuelan equine encephalitis virus vaccines induce mucosal IgA responses and protection from airborne infection in BALB/c, but not C3H/HeN mice. (9141206)
1997
34
Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. (7777497)
1995
35
Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. (7676619)
1995
36
Update: Venezuelan equine encephalitis--Colombia, 1995. (7565561)
1995
37
Molecular evidence for the origin of the widespread Venezuelan equine encephalitis epizootic of 1969 to 1972. (1469368)
1992
38
A single amino acid change in the E2 glycoprotein of Venezuelan equine encephalitis virus affects replication and dissemination in Aedes aegypti mosquitoes. (1919525)
1991
39
In vitro synthesis of infectious venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant. (2525837)
1989
40
Entomological studies at an enzootic Venezuelan equine encephalitis virus focus in Guatemala, 1977-1980. (2873752)
1986
41
Effects of ingestion of chlorocholine chloride and cyclophosphamide on Venezuelan equine encephalitis virus infections in deer mice (Peromyscus maniculatus). (6729837)
1984
42
Equine herds as sentinels for Venezuelan Equine encephalitis virus activity, Nicaragua 1977. (6860836)
1983
43
Studies of arboviruses in Southwestern Venezuela: I. Isolations of Venezuelan and Eastern Equine Encephalitis viruses from sentinel hamsters in the Catatumbo region. (1010667)
1976
44
Venezuelan equine encephalitis virus infection in man. (4824504)
1974
45
Incorporation of C 18 polyunsaturated fatty acids into L cell phospholipids under normal conditions and during infection with Venezuelan equine encephalitis virus. (5037925)
1972
46
Immunogenicity of purified venezuelan equine encephalitis virus inactivated by ionizing radiation. (16558020)
1971
47
Serologic evidence of Venezuelan equine encephalitis virus infections in raccoons of south central Florida. (5156482)
1971
48
Alterations in reticuloendothelial function by infection with attenuated Venezuelan equine encephalitis (VEE) virus. (5454416)
1970
49
Purification, concentration, and inactivation of Venezuelan equine encephalitis virus. (4922154)
1970
50
Alterations in immune responses by attenuated Venezuelan equine encephalitis vaccine. II. Pathology and soluble antigen localization in guinea pigs. (4890323)
1969

Genetic Variations for Venezuelan Equine Encephalitis

Expression for genes affiliated with Venezuelan Equine Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

Sources:
52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2, STAT1
2
Hide members
9.9STAT2, STAT1, TYK2
39.9TYK2, STAT1, STAT2
4
Hide members
9.9TYK2, STAT1, STAT2
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.9TYK2, STAT1, STAT2
6
Hide members
9.9STAT1, TYK2, RAB7A
79.9RAB7A, IFNB1
8
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.8CCL2, STAT1, TYK2
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.8TYK2, STAT1, CCL2
109.7IFNB1, STAT2, STAT1
119.5TYK2, STAT1, STAT2, IFNB1
129.5TYK2, STAT1, STAT2, IFNB1
139.5IFNB1, STAT2, STAT1, TYK2
14
Immune response IFN alpha/beta signaling pathway
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
159.5IFNB1, STAT2, STAT1, TYK2
16
Hide members
9.5IFNB1, STAT2, STAT1, TYK2
17
Hide members
9.4STAT1, STAT2, IFNB1, CCL2
189.4RAB5A, SH2D3C, STAT1, STAT2
19
Hide members
9.3CCL2, IFNB1, STAT2, STAT1, TYK2
20
Hide members
9.1CCL2, IFNB1, STAT2, STAT1, TYK2, FURIN

Compounds for genes affiliated with Venezuelan Equine Encephalitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1mumps4510.4STAT2, STAT1
2vanadate4510.2STAT2, STAT1, TYK2
3mdms4510.0STAT1, CCL2
42,5-oligoadenylate4510.0STAT1, STAT2, IFNB1
5estrogen4510.0BCAR3, FURIN
6serine4510.0CCL2, STAT2, STAT1, FURIN
7ifn-alpha459.9TYK2, STAT1, STAT2, IFNB1
8tetracycline45 1110.8CCL2, IFNB1, SAT1, FURIN
9mannose 6-phosphate45 2410.7FURIN, RAB7A, RAB5A
10sb 20358045 6010.7STAT1, SAT1, IFNB1, CCL2
11wortmannin459.7CCL2, STAT1, TYK2, RAB5A, LGALS3
12matrigel459.6RPSA, STAT1, IL32, LGALS3
13hcec459.5IFNB1, CCL2
14cisplatin45 50 60 1112.5CCL2, IFNB1, SAT1, STAT1, LGALS3
15superoxide45 2410.5CCL2, IFNB1, STAT1, LGALS3, FURIN
16ly294002459.5CCL2, IFNB1, STAT1, TYK2
17etoposide45 50 60 1112.5LGALS3, STAT1, IFNB1, RPSA
18h2o2459.5IFNB1, SAT1, STAT1, TYK2, LGALS3
19phosphatidylinositol459.4CCL2, STAT1, TYK2, RAB5A, RAB7A, LGALS3
20actinomycin d459.3CCL2, IFNB1, SAT1, STAT1
21cholesterol45 29 11 2412.3CCL2, IFNB1, STAT1, RAB7A, FURIN
22progesterone45 60 29 11 2413.2RPSA, IFNB1, STAT1, LGALS3, FURIN
23glucose459.0CCL2, IFNB1, SAT1, STAT1, RAB5A, FURIN
24cysteine458.8RPSA, IFNB1, STAT1, RAB5A, LGALS3, FURIN
25tyrosine458.8IFNB1, STAT2, STAT1, TYK2, IL32, RAB5A
26lipid458.6RPSA, CCL2, IFNB1, STAT1, RAB5A, RAB7A

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascadeGO:0072599.8STAT1, STAT2, CCL2
2regulation of type I interferon-mediated signaling pathwayGO:0603389.6TYK2, STAT1, STAT2, IFNB1
3type I interferon-mediated signaling pathwayGO:0603379.6IFNB1, STAT2, STAT1, TYK2
4cytokine-mediated signaling pathwayGO:0192219.3CCL2, IFNB1, STAT2, STAT1, TYK2
5defense response to virusGO:0516079.2DDX60, STAT1, STAT2, IFNB1
6small GTPase mediated signal transductionGO:0072648.3SH2D3A, SH2D3C, RAB5A, RAB7A, BCAR3

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanyl-nucleotide exchange factor activityGO:0050859.2BCAR3, SH2D3C, SH2D3A

Products for genes affiliated with Venezuelan Equine Encephalitis

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Sources for Venezuelan Equine Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet