MCID: VNZ002
MIFTS: 45

Venezuelan Equine Encephalitis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

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Aliases & Descriptions for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 11 48 13
Encephalomyelitis, Venezuelan Equine 39
Venezuelan Equine Encephalomyelitis 68
 
Encephalitis Venezuelan Equine 50
Venezuelan Equine Fever 11

Classifications:



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Disease Ontology11 DOID:9584
ICD1030 A92.2
ICD9CM32 066.2
MeSH39 D004685
NCIt45 C35121

Summaries for Venezuelan Equine Encephalitis

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Disease Ontology:11 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary: Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to encephalitis and mucositis, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways are Regulation of nuclear SMAD2/3 signaling and Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics. Affiliated tissues include brain of horses, brain and t cells, and related mouse phenotypes are hematopoietic system and neoplasm.

Related Diseases for Venezuelan Equine Encephalitis

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Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to venezuelan equine encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

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Symptoms:

 11 (show all 6)
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0IFNB1, IRF1, IRF7, LGALS3, RPSA, STAT1
2MP:00020067.6IFNB1, IRF1, LGALS3, SAT1, STAT1

Drugs & Therapeutics for Venezuelan Equine Encephalitis

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Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 2, Phase 16611
2MitogensPhase 11617

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis VaccineEnrolling by invitationNCT00582504Phase 2
2Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine in Healthy AdultsNot yet recruitingNCT03051386Phase 2
3Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83SuspendedNCT00582088Phase 2
4Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy VolunteersCompletedNCT01984983Phase 1
5A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901Active, not recruitingNCT01526473Phase 1
6Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus VaccineWithdrawnNCT00109304Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis


Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

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Anatomical Context for Venezuelan Equine Encephalitis

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MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

36
Brain, T cells, Myeloid, Testes, Olfactory bulb, Pancreas, Spleen

FMA organs/tissues related to Venezuelan Equine Encephalitis:

17
Brain of horses

Publications for Venezuelan Equine Encephalitis

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Articles related to Venezuelan Equine Encephalitis:

(show top 50)    (show all 428)
idTitleAuthorsYear
1
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. (27852852)
2017
2
Altered mitochondrial dynamics as a consequence of Venezuelan Equine Encephalitis Virus infection. (28075229)
2017
3
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. (27054586)
2016
4
Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. (27101567)
2016
5
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells. (27105836)
2016
6
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. (27318152)
2016
7
Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure. (27334491)
2016
8
Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood. (27870591)
2016
9
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. (27105216)
2016
10
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease. (27261892)
2016
11
A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA. (28042576)
2016
12
The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. (26656680)
2016
13
Bibliometric assessment of global research on Venezuelan Equine Encephalitis: A latent threat for the Americas. (27640115)
2016
14
Mayaro, Oropouche and Venezuelan Equine Encephalitis viruses: Following in the footsteps of Zika? (27826073)
2016
15
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. (27206386)
2016
16
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. (26792742)
2016
17
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. (27129427)
2016
18
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. (27030368)
2016
19
Role of angiotensin II in experimental Venezuelan equine encephalitis in rats. (26156105)
2015
20
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research. (26041283)
2015
21
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. (25908124)
2015
22
Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus. (27503577)
2015
23
Genetic diversity of Venezuelan alphaviruses and circulation of a Venezuelan equine encephalitis virus subtype IAB strain during an interepizootic period. (25940191)
2015
24
Demographics of natural oral infection of mosquitos by venezuelan equine encephalitis virus. (25589654)
2015
25
The ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection. (25927990)
2015
26
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain. (25725151)
2015
27
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. (26168898)
2015
28
Correction: IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. (26107877)
2015
29
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. (26020513)
2015
30
NMR study of non-structural proteins-part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). (25291978)
2014
31
Genetic and evolutionary characterization of Venezuelan equine encephalitis virus isolates from Argentina. (24833218)
2014
32
The role of IKKI^ in Venezuelan equine encephalitis virus infection. (24586253)
2014
33
Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. (24967809)
2014
34
Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. (25320296)
2014
35
Vesicular stomatitis virus glycoprotein- and venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors. (24125177)
2014
36
Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication. (25448087)
2014
37
Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus. (25244572)
2014
38
IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice. (23351391)
2013
39
Venezuelan equine encephalitis virus glycoprotein pseudotyping confers neurotropism to lentiviral vectors. (23171919)
2013
40
Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication. (24161512)
2013
41
Venezuelan equine encephalitis replicon particles can induce rapid protection against foot-and-mouth disease virus. (23468490)
2013
42
Pathogenesis of Venezuelan equine encephalitis. (23968890)
2013
43
Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus. (23988697)
2013
44
Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation. (23221545)
2013
45
Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication. (23637407)
2013
46
CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. (24210643)
2013
47
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus. (23408633)
2013
48
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions. (23365438)
2013
49
IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety. (23675542)
2013
50
Venezuelan Equine Encephalitis Viruses (VEEV) in Argentina: Serological Evidence of Human Infection. (24349588)
2013

Variations for Venezuelan Equine Encephalitis

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Expression for genes affiliated with Venezuelan Equine Encephalitis

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Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for genes affiliated with Venezuelan Equine Encephalitis

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Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.5IFNB1, IRF7
2
Show member pathways
9.3IRF7, STAT1
3
Show member pathways
9.1IRF1, STAT1
49.1IRF1, STAT1
5
Show member pathways
9.1IRF1, STAT1
69.1LGALS3, STAT1
79.0IFNB1, STAT1
89.0IFNB1, IRF1, IRF7
9
Show member pathways
9.0IFNB1, IRF1, IRF7
109.0IFNB1, IRF1, IRF7
118.5IFNB1, IRF1, STAT1
12
Show member pathways
8.5IFNB1, IRF1, STAT1
138.2IRF1, IRF7, LGALS3, STAT1
14
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
158.1IFNB1, IRF1, IRF7, STAT1
16
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
17
Show member pathways
8.1IFNB1, IRF1, IRF7, STAT1
18
Show member pathways
7.7IFNB1, IL32, IRF1, IRF7, STAT1

GO Terms for genes affiliated with Venezuelan Equine Encephalitis

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Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:003085510.3LGALS3, RPSA
2positive regulation of interferon-beta productionGO:003272810.3IRF1, IRF7
3positive regulation of type I interferon productionGO:003248110.2IRF1, IRF7
4regulation of adaptive immune responseGO:000281910.2IRF1, IRF7
5regulation of MyD88-dependent toll-like receptor signaling pathwayGO:003412410.2IRF1, IRF7
6regulation of type I interferon-mediated signaling pathwayGO:00603389.7IFNB1, STAT1
7interferon-gamma-mediated signaling pathwayGO:00603339.5IRF1, IRF7, STAT1
8cellular response to interferon-betaGO:00354589.2IFNB1, IRF1, STAT1
9viral processGO:00160328.9IRF7, RPSA, STAT1
10defense response to virusGO:00516078.9IFNB1, IRF1, IRF7, STAT1
11positive regulation of transcription from RNA polymerase II promoterGO:00459448.8IFNB1, IRF1, IRF7, STAT1
12type I interferon signaling pathwayGO:00603378.8IFNB1, IRF1, IRF7, STAT1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1laminin bindingGO:004323610.1LGALS3, RPSA
2regulatory region DNA bindingGO:000097510.1IRF1, IRF7
3RNA polymerase II core promoter sequence-specific DNA bindingGO:00009799.3IRF7, STAT1

Sources for Venezuelan Equine Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet