MCID: VNS002
MIFTS: 36

Venous Hemangioma

Categories: Cancer diseases

Aliases & Classifications for Venous Hemangioma

MalaCards integrated aliases for Venous Hemangioma:

Name: Venous Hemangioma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:467
NCIt 47 C4296
SNOMED-CT 64 403968005 56468002
UMLS 69 C0334532

Summaries for Venous Hemangioma

MalaCards based summary : Venous Hemangioma is related to hemopneumothorax and macular retinal edema. An important gene associated with Venous Hemangioma is KLF4 (Kruppel Like Factor 4), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and endothelial, and related phenotypes are cellular and normal

Related Diseases for Venous Hemangioma

Diseases related to Venous Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
id Related Disease Score Top Affiliating Genes
1 hemopneumothorax 30.1 CD34 HBA1
2 macular retinal edema 10.7 POU5F1 SOX2
3 adult pineoblastoma 10.6 HBA1 WT1
4 pneumothorax 10.6 POU5F1 SYP
5 atypical depressive disorder 10.6 POU5F1 WT1
6 factitious disorder 10.6 HBA1 SYP
7 superior mesenteric artery syndrome 10.6 SOX2 SYP
8 basophilic carcinoma 10.6 SYP WT1
9 anal canal squamous cell carcinoma 10.6 HBA1 SOX2
10 transitional cell cancer of the renal pelvis and ureter 10.5 SOX2 SYP
11 pleomorphic xanthoastrocytoma 10.5 SYP WT1
12 epithelioid sarcoma 10.5 SYP WT1
13 neurofibroma 10.5 CD34 HBA1
14 conventional angiosarcoma 10.5 CD34 HBA1
15 pleomorphic adenoma 10.5 CD34 HBA1
16 vulvar dystrophy 10.5 CD34 HBA1
17 dermoid cyst 10.5 CD34 HBA1
18 cervical adenoma malignum 10.5 CD34 HBA1
19 cervical endometrial stromal sarcoma 10.5 CD34 HBA1
20 coronary aneurysm 10.5 CD34 HBA1
21 salivary gland adenoid cystic carcinoma 10.5 CD34 HBA1
22 fibrillary astrocytoma 10.5 CD34 HBA1
23 thyroid angiosarcoma 10.5 CD34 HBA1
24 adult medulloblastoma 10.5 MYC SYP
25 gingival fibromatosis 10.5 MYC SOX2
26 median neuropathy 10.5 CD34 HBA1
27 hyperlucent lung 10.5 CD34 HBA1
28 rectosigmoid junction neoplasm 10.5 CD34 HBA1
29 childhood ovarian endodermal sinus tumor 10.5 SYP WT1
30 fibrosarcoma of bone 10.5 CD34 HBA1
31 mucinous intrahepatic cholangiocarcinoma 10.5 CD34 HBA1
32 connective tissue benign neoplasm 10.4 CD34 HBA1
33 tactile epilepsy 10.4 CD34 HBA1
34 mucin-rich endometrial endometrioid adenocarcinoma 10.4 CD34 HBA1
35 mannosidosis, beta 10.4 KLF4 POU5F1 SOX2
36 ossifying fibromyxoid tumor 10.4 CD34 HBA1
37 vulvar keratoacanthoma-like carcinoma 10.4 MYC SYP
38 juxtacortical osteosarcoma 10.4 MYC WT1
39 bone benign neoplasm 10.4 CD34 HBA1
40 c-p angle neurinoma 10.3 CD34 SOX2
41 hemangioma 10.3
42 perianal skin paget's disease 10.3 POU5F1 SOX2 SYP
43 leydig cell tumor 10.3 CD34 SYP
44 hilar cholangiocellular carcinoma 10.3 CD34 HBA1
45 central nervous system disease 10.3 POU5F1 SOX2 SYP
46 seminoma 10.3 SYP WT1
47 melanotic medulloblastoma 10.3 MYC SYP
48 peritoneal benign neoplasm 10.3 CD34 SYP
49 endometrioid ovary carcinoma 10.3 CD34 KLF4
50 ischemia 10.2 SOX2 SYP WT1

Graphical network of the top 20 diseases related to Venous Hemangioma:



Diseases related to Venous Hemangioma

Symptoms & Phenotypes for Venous Hemangioma

MGI Mouse Phenotypes related to Venous Hemangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CD34 EHD1 KLF4 MYC NANOG POU5F1
2 normal MP:0002873 9.56 CALB2 EHD1 KLF4 MYC POU5F1 SOX2
3 neoplasm MP:0002006 9.55 SOX2 WT1 CD34 KLF4 MYC
4 reproductive system MP:0005389 9.1 EHD1 KLF4 MYC POU5F1 SOX2 WT1

Drugs & Therapeutics for Venous Hemangioma

Drugs for Venous Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
8 Anti-Bacterial Agents Phase 2
9 Antibiotics, Antitubercular Phase 2
10 Antifungal Agents Phase 2
11 Anti-Infective Agents Phase 2
12 Immunosuppressive Agents Phase 2
13 Antiemetics Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Antimitotic Agents Phase 2
16 Antineoplastic Agents, Hormonal Phase 2
17 Antineoplastic Agents, Phytogenic Phase 2
18 Autonomic Agents Phase 2
19 Gastrointestinal Agents Phase 2
20 glucocorticoids Phase 2
21 Hormone Antagonists Phase 2
22 Hormones Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
24 Methylprednisolone acetate Phase 2
25 Methylprednisolone Hemisuccinate Phase 2
26 Neuroprotective Agents Phase 2
27 Peripheral Nervous System Agents Phase 2
28 Pharmaceutical Solutions Phase 2
29 Prednisolone acetate Phase 2
30 Prednisolone hemisuccinate Phase 2
31 Prednisolone phosphate Phase 2
32 Protective Agents Phase 2
33
Bevacizumab Approved, Investigational Phase 1 216974-75-3
34
Ranibizumab Approved Phase 1 347396-82-1 459903
35 Angiogenesis Inhibitors Phase 1
36 Angiogenesis Modulating Agents Phase 1
37 Antibodies Phase 1
38 Antibodies, Monoclonal Phase 1
39 Immunoglobulins Phase 1
40 Hematinics
41 Liver Extracts
42 GTPase-Activating Proteins

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
2 Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas Terminated NCT00555464 Phase 2 Vincristine;Prednisone
3 Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00089765 Phase 1 Ranibizumab
4 EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00056199 Phase 1 EYE001
5 Gadofosveset Trisodium (Ablavar, Gdfos) in Distinguishing Hemangiomas and Metastases: A Prospective Trial Unknown status NCT02036008
6 Evaluation and Optimization of the Technical and Clinical Performance of the Lumenis ONE Platform Unknown status NCT00247299
7 Identification of Genetic and Cellular Markers Associated With Vascular Endothelial Modifications in Cutaneous Arteriovenous Malformations Unknown status NCT01774916
8 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
9 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
10 Pilot Study of PDL to Treat BCC and SCCIS Completed NCT01245972
11 Safety of Apollo Micro Catheter in Pediatric Patients Completed NCT02085278
12 Classical Procedure Versus Intrahepatic Glisson's Approach Recruiting NCT01567631
13 Airway Vascular Lesions Active, not recruiting NCT00866827
14 French National Cohort of Children With Port Wine Stain Active, not recruiting NCT01364857
15 Multicenter Validation of the AVICH Score Enrolling by invitation NCT02920645
16 Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations Not yet recruiting NCT03031873
17 Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm Terminated NCT01801488

Search NIH Clinical Center for Venous Hemangioma

Genetic Tests for Venous Hemangioma

Anatomical Context for Venous Hemangioma

MalaCards organs/tissues related to Venous Hemangioma:

39
Liver, Brain, Endothelial, Skeletal Muscle

Publications for Venous Hemangioma

Articles related to Venous Hemangioma:

(show all 38)
id Title Authors Year
1
Debulking surgery for venous hemangioma arising from the epicardium: report of a case. ( 28403869 )
2017
2
Spontaneous Hemothorax Caused by Pulmonary Micro-Venous Hemangioma. ( 26140771 )
2015
3
Venous hemangioma of the anterior mediastinum. ( 25370300 )
2014
4
Submandibular venous hemangioma: Case report and review of the literature. ( 25502778 )
2014
5
A tentorial venous hemangioma presenting as an extra-axial mass in the ambient cistern: a case report. ( 23946924 )
2012
6
Venous hemangioma of the posterior mediastinum. ( 22790999 )
2012
7
Orbital venous hemangioma. ( 21234590 )
2012
8
Thoracoscopic resection of a mediastinal venous hemangioma: Report of a case. ( 21922378 )
2011
9
Venous hemangioma of parapharyngeal space with calcification. ( 22232718 )
2011
10
Retroperitoneal venous hemangioma. ( 20438591 )
2010
11
Venous hemangioma presenting as a superior sulcus tumor. ( 21095359 )
2010
12
Venous hemangioma of the anterior mediastinum. ( 20453425 )
2010
13
Intercostal venous hemangioma presenting as a chest wall tumor. ( 19367460 )
2009
14
Snapping hip caused by a venous hemangioma of the gluteus maximus muscle: a case report. ( 19087261 )
2008
15
Venous hemangioma in the right atrium possibly related to radiofrequency catheter ablation. ( 18728339 )
2008
16
Subcutaneous venous hemangioma of the breast. ( 17646373 )
2007
17
Venous hemangioma of the azygos arch. ( 17681805 )
2007
18
Spontaneous hemopneumothorax as a result of venous hemangioma: a unique case? ( 16572882 )
2006
19
Venous hemangioma arising from the diaphragm: a case report of computed tomography and magnetic resonance imaging findings. ( 16915071 )
2006
20
Endoscopic resection of a venous hemangioma of the optic nerve sheath. ( 16261759 )
2005
21
Retroperitoneal venous hemangioma. ( 16276446 )
2005
22
Laparoscopic resection of retroperitoneal venous hemangioma. ( 14665912 )
2004
23
Venous hemangioma of the mediastinum. ( 11194921 )
2001
24
Venous hemangioma of the scrotum: a case report. ( 11215201 )
2000
25
Retroperitoneal venous hemangioma. ( 9820421 )
1998
26
Venous hemangioma of the mesocolon. ( 9242791 )
1997
27
Venous hemangioma. An immunohistochemical and ultrastructural study. ( 9298133 )
1997
28
Vanishing tumor of the temporalis muscle: repeated hemorrhage in an intramuscular venous hemangioma. ( 9159382 )
1997
29
Venous hemangioma of the temporalis muscle. ( 8786831 )
1996
30
Venous hemangioma of the mesoappendix: report of a case and a brief review of the Japanese literature. ( 8640022 )
1995
31
Venous hemangioma of the internal auditory canal. ( 7675497 )
1995
32
Synovial venous hemangioma of the knee joint. ( 2774881 )
1989
33
An immunohistochemical and electron microscopic study of a central venous hemangioma of the mandible. ( 3113407 )
1987
34
Venous hemangioma with phleboliths--a case study using immunohistochemistry, scanning electron microscopy and x-ray microdiffraction. ( 3323426 )
1987
35
Venous hemangioma of the gallbladder. ( 3305129 )
1987
36
Bleeding of a venous hemangioma inside the filum terminale. ( 3028240 )
1986
37
Vascular tumors of the breast. IV. The venous hemangioma. ( 4051098 )
1985
38
VENOUS HEMANGIOMA OF SKELETAL MUSCLE: CASE REPORT. ( 17858282 )
1943

Variations for Venous Hemangioma

Expression for Venous Hemangioma

Search GEO for disease gene expression data for Venous Hemangioma.

Pathways for Venous Hemangioma

GO Terms for Venous Hemangioma

Cellular components related to Venous Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.62 KLF4 POU5F1

Biological processes related to Venous Hemangioma according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.81 KLF4 MYC SOX2 WT1
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.8 KLF4 MYC NANOG POU5F1 SOX2 WT1
3 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.77 KLF4 MYC POU5F1 SOX2 WT1
4 positive regulation of gene expression GO:0010628 9.71 CD34 KLF4 MYC POU5F1
5 negative regulation of gene expression GO:0010629 9.65 CD34 KLF4 POU5F1
6 regulation of gene expression GO:0010468 9.56 MYC NANOG POU5F1 SOX2
7 transcription from RNA polymerase II promoter GO:0006366 9.55 KLF4 MYC POU5F1 SOX2 WT1
8 branching involved in ureteric bud morphogenesis GO:0001658 9.54 MYC WT1
9 regulation of cell differentiation GO:0045595 9.52 KLF4 NANOG
10 positive regulation of telomerase activity GO:0051973 9.49 KLF4 MYC
11 response to growth factor GO:0070848 9.46 MYC SOX2
12 oxygen transport GO:0015671 9.43 HBA1 MYC
13 somatic stem cell population maintenance GO:0035019 9.26 KLF4 NANOG POU5F1 SOX2
14 endodermal cell fate specification GO:0001714 8.8 NANOG POU5F1 SOX2

Molecular functions related to Venous Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.56 KLF4 MYC SOX2 WT1
2 sequence-specific DNA binding GO:0043565 9.55 KLF4 NANOG POU5F1 SOX2 WT1
3 miRNA binding GO:0035198 9.32 POU5F1 SOX2
4 transcription regulatory region DNA binding GO:0044212 9.13 KLF4 SOX2 WT1
5 transcription factor activity, sequence-specific DNA binding GO:0003700 9.1 KLF4 MYC NANOG POU5F1 SOX2 WT1

Sources for Venous Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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