MCID: VNS003
MIFTS: 53

Venous Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 28 41 14 69
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 34 459.81
MeSH 41 D014689
SNOMED-CT 64 20696009
ICD10 32 I87.2
UMLS 69 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Lidocaine and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Venous insufficiency can refer... more...

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.2 MMP1 PLAT
2 post-thrombotic syndrome 32.2 F2 ICAM1 SERPINE1
3 chronic venous insufficiency 30.8 ICAM1 ITGA4 ITGAM MMP1 PLAT SELL
4 multiple sclerosis 30.0 ICAM1 ITGA4 TIMP1 VCAM1
5 thrombophlebitis 29.8 F2 PLAT SERPINE1
6 buerger disease 29.8 F2 SERPINE1
7 chronic venous leg ulcers 29.7 ITGA4 TIMP1
8 thrombophilia due to thrombin defect 29.7 F2 PLAT SERPINE1 VWF
9 thrombosis 29.5 F2 PLAT SELP SERPINE1 VWF
10 arteriosclerosis obliterans 29.4 ICAM1 SELP VCAM1
11 peripheral artery disease 29.4 CRP SELP VCAM1
12 varicose veins 29.3 F2 MMP1 TIMP1 VWF
13 thrombophilia 29.2 F2 PLAT SERPINE1 VWF
14 arteriosclerosis 28.4 CRP ICAM1 SELP SERPINE1 VCAM1
15 vasculitis 28.2 CRP ICAM1 SELL VCAM1 VWF
16 vascular disease 28.0 CRP PLAT SELP SERPINE1 VCAM1 VWF
17 systemic lupus erythematosus 27.8 CRP F2 ICAM1 ITGAM VCAM1 VWF
18 peripheral vascular disease 27.6 CRP F2 PLAT SELP SERPINE1 VCAM1
19 arteries, anomalies of 27.4 CRP F2 ICAM1 PLAT SELP SERPINE1
20 fibrinolytic defect 10.5 PLAT SERPINE1
21 plasminogen activator inhibitor-1 deficiency 10.5 PLAT SERPINE1
22 argentine hemorrhagic fever 10.5 PLAT SERPINE1
23 central serous chorioretinopathy 10.5 PLAT SERPINE1
24 livedoid vasculopathy 10.5 F2 SERPINE1
25 intracranial embolism 10.4 F2 PLAT
26 ischemic colitis 10.4 F2 SERPINE1
27 cryptogenic cirrhosis 10.4 F2 SERPINE1
28 marantic endocarditis 10.4 F2 PLAT
29 toxicodendron dermatitis 10.4 ICAM1 SELL
30 chronic monocytic leukemia 10.4 F2 ITGAM
31 cohen syndrome 10.4 ITGAM SELL
32 retinal artery occlusion 10.4 F2 SERPINE1
33 acute cor pulmonale 10.4 PLAT SERPINE1
34 basilar artery occlusion 10.4 F2 PLAT
35 plummer's disease 10.4 ICAM1 SELL
36 peliosis hepatis 10.3 F2 ITGA4 SELL
37 carotid artery thrombosis 10.3 PLAT SELP SERPINE1
38 disseminated intravascular coagulation 10.3 F2 PLAT SERPINE1
39 eisenmenger syndrome 10.3 PLAT VWF
40 arthus reaction 10.3 ICAM1 SELL
41 hydrocele 10.3 ICAM1 ITGA4
42 cortical thymoma 10.3 ICAM1 VCAM1
43 retinal vascular occlusion 10.3 F2 SELP
44 von willebrand disease, type 1 10.3 F2 VWF
45 active peptic ulcer disease 10.3 F2 VWF
46 multiple symmetrical lipomatosis 10.3 SELP VCAM1
47 cardiogenic shock 10.2 CRP PLAT
48 malignant otitis externa 10.2 CRP F2
49 factor viii deficiency 10.2 F2 VWF
50 portal vein thrombosis 10.2 F2 SELP SERPINE1

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 VCAM1 PLAT VWF SELL CRP SELP
2 hematopoietic system MP:0005397 10 ITGAM VCAM1 PLAT VWF SELL SELP
3 homeostasis/metabolism MP:0005376 9.93 ITGAM MMP1 VCAM1 PLAT VWF SELL
4 immune system MP:0005387 9.77 VCAM1 MMP1 PLAT VWF SELL CRP
5 respiratory system MP:0005388 9.1 TIMP1 PLAT SELL SELP F2 SERPINE1

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Polidocanol Approved Phase 4,Phase 3 9002-92-0
3
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Phase 2 139-88-8, 1191-50-0 5248 14492
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5 Racepinephrine Approved Phase 4 329-65-7
6
Rivaroxaban Approved Phase 4 366789-02-8
7
Glucosamine Approved, Investigational, Nutraceutical Phase 4,Early Phase 1 3416-24-8 439213
8
Troxerutin Investigational Phase 4 7085-55-4 5486699
9 Anesthetics Phase 4
10 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
11 Anesthetics, Local Phase 4
12 Anti-Arrhythmia Agents Phase 4
13 Central Nervous System Depressants Phase 4
14 Diuretics, Potassium Sparing Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Sodium Channel Blockers Phase 4
17 Anticoagulants Phase 4,Phase 3
18 Heparinoids Phase 4
19 Salicylates Phase 4,Phase 1,Phase 2
20 Aminaftone Phase 4
21 Coagulants Phase 4,Phase 3
22 Hemostatics Phase 4,Phase 3
23 Anti-Inflammatory Agents Phase 4
24 Fibrinolytic Agents Phase 4,Phase 3
25 Adrenergic Agents Phase 4
26 Adrenergic Agonists Phase 4
27 Adrenergic alpha-Agonists Phase 4
28 Adrenergic beta-Agonists Phase 4
29 Anti-Asthmatic Agents Phase 4,Phase 2
30 Autonomic Agents Phase 4,Phase 2
31 Bronchodilator Agents Phase 4,Phase 2
32 Epinephryl borate Phase 4
33 Mydriatics Phase 4
34 Neurotransmitter Agents Phase 4,Phase 2
35 Respiratory System Agents Phase 4,Phase 2
36 Vasoconstrictor Agents Phase 4
37 Antithrombin III Phase 4
38 Antithrombins Phase 4
39 Factor Xa Inhibitors Phase 4
40 HIV Protease Inhibitors Phase 4
41
protease inhibitors Phase 4
42 Serine Proteinase Inhibitors Phase 4
43 Antimetabolites Phase 4
44 Glucuronyl glucosamine glycan sulfate Phase 4
45 Hypoglycemic Agents Phase 4
46 Hypolipidemic Agents Phase 4
47 Lipid Regulating Agents Phase 4
48 Calamus Nutraceutical Phase 4
49
Coumarin Experimental, Nutraceutical Phase 4 91-64-5 323
50 serine Nutraceutical Phase 4

Interventional clinical trials:

(show top 50) (show all 232)

# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
3 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
4 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
5 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
6 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
7 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
9 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
10 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
11 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
12 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
13 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
14 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
15 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
16 Lake Washington Vascular VenaSeal™ Post-Market Evaluation (WAVES) Completed NCT02585726 Phase 4
17 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
18 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
19 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
20 Rivaroxaban With Diosmine in Long-term Treatment of DVT Recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
21 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
22 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Terminated NCT02512601 Phase 4 Sulodexide
23 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
24 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
25 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
26 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
27 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
28 Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers Unknown status NCT00232973 Phase 3 ICXP007
29 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
30 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
31 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
32 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
33 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
34 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
35 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
36 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
37 Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux Completed NCT02211898 Phase 3 BNS003
38 ESGVS: Sclerotherapy With Lauromacrogol Completed NCT00348764 Phase 3 lauromacrogol
39 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
40 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
41 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
42 Biomarker Sub Study of the Compression Stockings to Prevent the Post-Thrombotic Syndrome (SOX) Trial Completed NCT01615705 Phase 3
43 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
44 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
45 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
46 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3 Platelet-Rich Plasma
47 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Not yet recruiting NCT02927483 Phase 3
48 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Not yet recruiting NCT02767232 Phase 3 Recombinant tissue plasminogen activator (rt-PA);Standard Anticoagulation Therapy
49 EVENT: Hydrotherapy and Deep Venous Thrombosis Terminated NCT00348907 Phase 3 thermal cure;late thermal cure
50 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 28

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

38
Skin, Bone, Testes, Endothelial, Brain, Heart, Neutrophil

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 660)
# Title Authors Year
1
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
2
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
3
Iliac vein stenosis is an underdiagnosed cause of pelvic venous insufficiency. ( 29292119 )
2018
4
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
5
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
6
TGF-I^1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology. ( 29186866 )
2017
7
Mechanochemical Ablation for Treatment of Truncal Venous Insufficiency: A Review of the Current Literature. ( 28811080 )
2017
8
Chronic Venous Insufficiency: Transforming Growth Factor-I^ Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing. ( 29065449 )
2017
9
Evaluation of inflammatory cell biomarkers in chronic venous insufficiency. ( 28379059 )
2017
10
Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis. ( 28721810 )
2017
11
Effects of isokinetic calf muscle exercise program on muscle strength and venous function in patients with chronic venous insufficiency. ( 28954574 )
2017
12
Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency. ( 29019582 )
2017
13
Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency. ( 29123633 )
2017
14
Chronic Venous Insufficiency: a Frequently Underdiagnosed and Undertreated Pathology. ( 28878840 )
2017
15
Venous Insufficiency ( 28613694 )
2017
16
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency. ( 28873064 )
2017
17
Case of chronic venous insufficiency-associated Kaposi's sarcoma in a Japanese patient. ( 28771851 )
2017
18
Venous ultrasonography findings and clinical correlations in 104 Thai patients with chronic venous insufficiency of the legs. ( 28503700 )
2017
19
Changing Medicare Utilization of Minimally Invasive Procedures for the Treatment of Chronic Venous Insufficiency. ( 28396193 )
2017
20
A failure of preoperative duplex imaging to diagnose a lower extremity venous aneurysm in a patient with severe chronic venous insufficiency. ( 28255445 )
2017
21
Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. ( 28662285 )
2017
22
The calendar of cytokines: Seasonal variation of circulating cytokines in chronic venous insufficiency. ( 28959442 )
2017
23
Increased inflammatory status in chronic venous insufficiency patients. ( 28592220 )
2017
24
Chronic Venous Insufficiency: Novel Management Strategies for an Under-diagnosed Disease Process. ( 28459920 )
2017
25
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
26
Contact Sensitization in Patients With Lower Leg Dermatitis, Chronic Venous Insufficiency, and/or Chronic Leg Ulcer: Assessment of the Clinical Relevance of Contact Allergens. ( 29199962 )
2017
27
Endovenous laser ablation in patients with severe primary chronic venous insufficiency. ( 28139903 )
2017
28
Primary pulmonary arterial hypertension with preserved right ventricular function leads to lower extremity venous insufficiency. ( 28835185 )
2017
29
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
30
Update on Current Care Guideline: Venous insufficiency of the lower limb. ( 29243470 )
2017
31
Cultural adaptation and validation of the Swedish VEINES-QOL/Sym in patients with venous insufficiency. ( 28954585 )
2017
32
Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings. ( 28804235 )
2017
33
Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. ( 29171654 )
2017
34
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment. ( 28485865 )
2017
35
Nocturnal leg symptoms are not associated with specific patterns of superficial venous insufficiency. ( 28854778 )
2017
36
Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency. ( 28430292 )
2017
37
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations. ( 28403688 )
2017
38
Echocolor Doppler morpho-functional study of the jugulo-subclavian confluence in chronic cerebro-spinal venous insufficiency and multiple sclerosis patients. ( 29339583 )
2017
39
Treatment of incompetent perforators in recurrent venous insufficiency with adhesive embolization and sclerotherapy. ( 28956508 )
2017
40
The relationship between chronic venous insufficiency and diabetes mellitus. ( 28124879 )
2017
41
Preliminary results of severe venous insufficiency treatment with thermal ablation of the great saphenous vein by endovascular technique with laser diode 980nm developed in Brazil, associated with sclerotherapy with polidocanol. ( 28767808 )
2017
42
N-butyl cyanoacrylate in the treatment of venous insufficiency - the effect of embolisation with ablative polymerisation. ( 27129070 )
2016
43
Phlebotonics for venous insufficiency. ( 27048768 )
2016
44
Venous compression syndrome of internal jugular veins prevalence in patients with multiple sclerosis and chronic cerebro-spinal venous insufficiency. ( 27842009 )
2016
45
Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don't tell, they won't know. ( 27982166 )
2016
46
The Impact of Race on Advanced Chronic Venous Insufficiency. ( 27179983 )
2016
47
The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction. ( 26924360 )
2016
48
Response to letter regarding Embolization is not essential in the treatment of leg varices due to pelvic venous insufficiency. ( 27380947 )
2016
49
Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. ( 27914110 )
2016
50
Compression in the treatment of chronic venous insufficiency: Efficacy depending on the length of the stocking. ( 27886005 )
2016

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CRP ICAM1 ITGA4 ITGAM MMP1 SELL
2
Show member pathways
13.2 ICAM1 ITGAM MMP1 TIMP1 VCAM1 VWF
3
Show member pathways
12.51 ICAM1 ITGA4 ITGAM VCAM1
4
Show member pathways
12.46 ICAM1 ITGA4 ITGAM MMP1 SERPINE1 TIMP1
5
Show member pathways
12.4 F2 ITGA4 ITGAM MMP1 PLAT SELL
6
Show member pathways
12.23 CRP F2 ICAM1 PLAT SERPINE1
7
Show member pathways
12.09 F2 ICAM1 ITGA4 ITGAM MMP1 VCAM1
8
Show member pathways
12.06 F2 PLAT SERPINE1 VWF
9
Show member pathways
12.03 ICAM1 ITGA4 ITGAM VCAM1 VWF
10 11.98 ICAM1 ITGA4 SELL VCAM1
11 11.96 ICAM1 PLAT VCAM1
12 11.94 F2 ITGAM PLAT SERPINE1 VWF
13 11.92 ICAM1 ITGA4 SERPINE1 VCAM1
14
Show member pathways
11.89 F2 ITGA4 ITGAM MMP1 SELL SELP
15 11.78 ICAM1 ITGAM MMP1 TIMP1 VCAM1
16 11.77 ICAM1 SERPINE1 VCAM1
17 11.59 ICAM1 ITGA4 VCAM1
18 11.59 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
19
Show member pathways
11.56 ICAM1 MMP1 VCAM1
20 11.56 MMP1 PLAT SERPINE1 TIMP1
21 11.5 ICAM1 ITGAM SELP
22 11.43 ICAM1 SELP VCAM1
23 11.42 ICAM1 ITGAM PLAT SELP
24 11.31 ICAM1 ITGA4 ITGAM VCAM1
25 11.1 F2 ICAM1 TIMP1
26 10.96 F2 MMP1
27 10.91 MMP1 TIMP1
28 10.83 ICAM1 VCAM1
29 10.72 PLAT SERPINE1

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 CRP F2 ICAM1 ITGA4 ITGAM PLAT
2 extracellular region GO:0005576 9.95 CRP F2 MMP1 PLAT SERPINE1 TIMP1
3 extracellular space GO:0005615 9.81 CRP F2 ICAM1 ITGAM PLAT SELP
4 cell surface GO:0009986 9.8 ICAM1 ITGA4 ITGAM PLAT SELL VCAM1
5 platelet alpha granule lumen GO:0031093 9.54 SERPINE1 TIMP1 VWF
6 extracellular matrix GO:0031012 9.43 ICAM1 MMP1 PLAT SERPINE1 TIMP1 VWF
7 external side of plasma membrane GO:0009897 9.1 F2 ICAM1 ITGAM SELL SELP VCAM1

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.87 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
2 regulation of immune response GO:0050776 9.76 ICAM1 ITGA4 SELL VCAM1
3 response to hypoxia GO:0001666 9.75 ICAM1 PLAT VCAM1
4 platelet degranulation GO:0002576 9.71 SELP SERPINE1 TIMP1 VWF
5 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 ITGAM SERPINE1 VCAM1 VWF
6 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.61 ICAM1 SELP VCAM1
7 negative regulation of proteolysis GO:0045861 9.57 F2 PLAT
8 calcium-mediated signaling using intracellular calcium source GO:0035584 9.56 SELP VCAM1
9 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
10 blood coagulation, intrinsic pathway GO:0007597 9.55 F2 VWF
11 positive regulation of leukocyte migration GO:0002687 9.54 ITGA4 SELP
12 fibrinolysis GO:0042730 9.54 F2 PLAT SERPINE1
13 positive regulation of superoxide anion generation GO:0032930 9.52 CRP ITGAM
14 positive regulation of blood coagulation GO:0030194 9.51 F2 SERPINE1
15 negative regulation of fibrinolysis GO:0051918 9.49 F2 SERPINE1
16 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
17 leukocyte tethering or rolling GO:0050901 9.26 ITGA4 SELL SELP VCAM1
18 leukocyte migration GO:0050900 9.17 F2 ICAM1 ITGA4 ITGAM MMP1 SELL

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.54 F2 SELL SELP
2 integrin binding GO:0005178 9.5 ICAM1 VCAM1 VWF
3 cell adhesion molecule binding GO:0050839 9.33 ITGA4 SELL VCAM1
4 oligosaccharide binding GO:0070492 9.26 SELL SELP
5 glycosphingolipid binding GO:0043208 8.96 SELL SELP
6 protease binding GO:0002020 8.92 SELL SERPINE1 TIMP1 VWF

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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