MCID: VNS003
MIFTS: 39

Venous Insufficiency malady

Cardiovascular diseases category

Aliases & Classifications for Venous Insufficiency

About this section

Venous Insufficiency, Aliases & Descriptions:

Name: Venous Insufficiency 9 11 60
 
Peripheral Venous Insufficiency 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:10128
ICD9CM27 459.81
SNOMED-CT55 20696009
MeSH33 D014689
ICD1025 I87.2

Summaries for Venous Insufficiency

About this section


Wikipedia:63 Venous insufficiency can refer to: more...

MalaCards based summary: Venous Insufficiency, also known as peripheral venous insufficiency, is related to chronic venous insufficiency and vasculitis. An important gene associated with Venous Insufficiency is ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)), and among its related pathways are Paxillin-dependent events mediated by a4b1 and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs gotu kola extract and gotu kola liquid and the compounds slex and proadifen have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and brain.

Disease Ontology:9 A vein disease that is characterized by impaired flow of blood through the veins.

Related Diseases for Venous Insufficiency

About this section

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1chronic venous insufficiency31.9ITGA4, VCAM1, PPIG
2vasculitis30.2ITGA4, VCAM1
3varicose veins10.6
4blindness10.5
5endotheliitis10.4
6ehlers-danlos syndrome classical type10.4
7norrie disease10.3
8obesity10.3
9necrobiosis lipoidica10.3
10cerebritis10.3
11post-thrombotic syndrome10.2
12lipodermatosclerosis10.2
13nephritis10.2VCAM1, ITGA4
14hypertriglyceridemia10.1VCAM1, PPIG
15eosinophilia10.1VCAM1, ITGA4
16ehlers-danlos syndrome, type iii10.1
17parkes weber syndrome10.1
18klippel-trenaunay-weber syndrome10.1
19microphthalmia with limb anomalies10.1
20hypotrichosis-lymphedema-telangiectasia syndrome10.1
21velocardiofacial syndrome10.1
22menkes disease10.1
23occipital horn syndrome10.1
24ehlers-danlos syndrome, type iv10.1
25capillary malformations, congenital, 1, somatic, mosaic10.1
26arteriovenous fistula10.1
27chronic venous leg ulcers10.1
28skin disease10.1
29thoracic outlet syndrome10.1
30von willebrand's disease10.1
31cadasil10.1
32protein c deficiency10.1
33cervicitis10.1
34elephantiasis10.1
35torticollis keloids cryptorchidism renal dysplasia10.1
36proteus-like syndrome10.1
37angioosteohypertrophic syndrome10.1
38segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.1
39hereditary thrombophilia due to congenital protein s deficiency10.1
40encephalitis10.1ITGA4, VCAM1
41glomerulonephritis10.1ITGA4, VCAM1
42allergic asthma10.1ITGA4, VCAM1
43primary hyperoxaluria10.0ITGA4, VCAM1, PPIG
44hypersensitivity reaction type ii disease10.0ITGA4, VCAM1, PPIG
45psoriasis10.0VCAM1, ITGA4, KRT10
46atherosclerosis10.0ITGA4, VCAM1, PPIG
47porphyria cutanea tarda10.0
48systemic lupus erythematosus10.0
49breast cancer10.0
50kaposi sarcoma10.0

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to venous insufficiency

Symptoms for Venous Insufficiency

About this section

Drugs & Therapeutics for Venous Insufficiency

About this section

Drug clinical trials:

Search ClinicalTrials for Venous Insufficiency

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Venous Insufficiency

About this section

Anatomical Context for Venous Insufficiency

About this section

MalaCards organs/tissues related to Venous Insufficiency:

31
Skin, Endothelial, Brain, Heart, Breast, Testes, Monocytes, Neutrophil

Animal Models for Venous Insufficiency or affiliated genes

About this section

Publications for Venous Insufficiency

About this section

Articles related to Venous Insufficiency:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. (25630350)
2015
2
Influence of manual lymphatic drainage on health-related quality of life and symptoms of chronic venous insufficiency: a randomized controlled trial. (25308883)
2014
3
Superficial venous insufficiency from the infernal to the endothermal. (24417822)
2014
4
Recommendations for Multimodal Noninvasive and Invasive Screening for Detection of Extracranial Venous Abnormalities Indicative of Chronic Cerebrospinal Venous Insufficiency: A Position Statement of the International Society for Neurovascular Disease. (25255703)
2014
5
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency in people with multiple sclerosis: a summary of a Cochrane systematic review. (23781006)
2013
6
Analysis of the association between an insertion/deletion polymorphism within the 3' untranslated region of COL1A2 and chronic venous insufficiency. (23849651)
2013
7
A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. (23533507)
2013
8
Ultrasound-guided foam sclerotherapy within a rolling treatment programme is an effective low-cost treatment for superficial venous insufficiency. (22357459)
2013
9
Combination Therapy of Hyaluronic Acid Mesotherapic Injections and Sclerotherapy for Treatment of Lower Leg Telangiectasia Without Major Venous Insufficiency: A Preliminary Clinical Study. (23076772)
2013
10
CHIVA method for the treatment of chronic venous insufficiency. (23821413)
2013
11
Effects of kinesio taping on venous symptoms, bioelectrical activity of the gastrocnemius muscle, range of ankle motion, and quality of life in postmenopausal women with chronic venous insufficiency: a randomized controlled trial. (23769763)
2013
12
Non-pharmacological interventions for preventing venous insufficiency in a standing worker population. (24127117)
2013
13
Cost and effectiveness of laser with phlebectomies compared with foam sclerotherapy in superficial venous insufficiency. Early results of a randomised controlled trial. (22386383)
2012
14
Early clinical improvement in chronic venous insufficiency symptoms after laser ablation of saphenous veins. (22767250)
2012
15
Chronic venous insufficiency stage v ceap secondary to hereditary thrombophilia at a young man. (23700886)
2012
16
Multiple sclerosis, an unlikely cause of chronic cerebrospinal venous insufficiency: retrospective analysis of catheter venography. (23301144)
2012
17
MicroRNA profiling in great saphenous vein tissues of patients with chronic venous insufficiency. (23132275)
2012
18
Longevity and outcomes of axillary valve transplantation for severe lower extremity chronic venous insufficiency. (21549918)
2011
19
Review of venous anatomy for venographic interpretation in chronic cerebrospinal venous insufficiency. (21975259)
2011
20
Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity. (21786298)
2011
21
Ask the doctor. I have been diagnosed with venous insufficiency. What does that mean? (21560791)
2011
22
Postoperative leucocytoclastic vasculitis in free flap mimicking venous insufficiency. (21530432)
2011
23
Multiple sclerosis and chronic cerebrospinal venous insufficiency: the neuroimaging perspective. (21292801)
2011
24
Validation of the chronic venous insufficiency quality of life questionnaire in Dutch patients treated for varicose veins. (21531589)
2011
25
Chronic cerebrospinal venous insufficiency and multiple sclerosis. (20373339)
2010
26
Avenues to prevent venous insufficiency. (20671645)
2010
27
Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study. (20351673)
2010
28
To what extent might deep venous thrombosis and chronic venous insufficiency share a common etiology? (19648868)
2009
29
Effect of chronic venous insufficiency on activities of daily living and quality of life: correlation of demographic factors with duplex ultrasonography findings. (17875957)
2007
30
Initial experience of subfascial endoscopic perforator vein surgery in patients with severe chronic venous insufficiency. (17966938)
2007
31
Immune function of erythrocytes in patients with chronic venous insufficiency of the lower extremities. (18167207)
2007
32
Subfascial endoscopic perforator vein surgery using balloon dissector and saphenous vein surgery in chronic venous insufficiency. (18268864)
2007
33
Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. (18091707)
2007
34
Dermacase. Chronic venous insufficiency. (17279179)
2006
35
Ankle mobility in relation to chronic venous insufficiency in HIV-positive persons with and without a history of injection drug use. (16849087)
2006
36
Chronic venous insufficiency. Preventing leg ulcers is primary goal. (16035549)
2005
37
Radionuclide assessment of the treatment by compression of patients with chronic venous insufficiency. (16474294)
2005
38
HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study. (15793606)
2005
39
Efficacy of topical treatment with aescin + essential phospholipids gel in a microcirculatory model of venous insufficiency. (15156252)
2004
40
Endovenous laser ablation of the saphenous vein for treatment of venous insufficiency and varicose veins: early results from a large single-center experience. (15056020)
2004
41
Treating venous insufficiency with soft silicone dressing. (15509877)
2004
42
Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency. (14612852)
2003
43
The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study. (12236023)
2002
44
Chronic venous insufficiency--epidemiology. (12413204)
2002
45
Pharmaco-epidemiology of the treatment of chronic venous insufficiency in general medicine. (12515975)
2002
46
Preoperative duplex-derived parameters and angioscopic evidence of valvular incompetence associated with superficial venous insufficiency. (12010107)
2002
47
Methods of evaluation and quantification of microangiopathy in high perfusion microangiopathy (chronic venous insufficiency and diabetic microangiopathy). (12011965)
2002
48
Quality of life (Spain and France): validation of the chronic venous insufficiency questionnaire (CIVIQ). (12428431)
2002
49
Role of ultrasound in the assessment of chronic venous insufficiency. (12973085)
2001
50
Changes of cytokeratin expression in the epidermis with chronic venous insufficiency. (9174381)
1997

Variations for Venous Insufficiency

About this section

Expression for genes affiliated with Venous Insufficiency

About this section
Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for genes affiliated with Venous Insufficiency

About this section

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b736
a4b1 and a4b7 Integrin signaling36
9.7VCAM1, ITGA4
29.7ITGA4, VCAM1
39.7ITGA4, VCAM1
49.7ITGA4, VCAM1
5
Show member pathways
8.9CLDN1, VCAM1, ITGA4
68.9CLDN1, VCAM1, ITGA4
78.9ITGA4, VCAM1, CLDN1
88.9ITGA4, VCAM1, CLDN1

Compounds for genes affiliated with Venous Insufficiency

About this section

Compounds related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1slex439.9VCAM1, ITGA4
2proadifen439.9VCAM1, PPIG
3pentoxifylline43 1210.8VCAM1, ITGA4
4erythromycin43 2 49 1212.8VCAM1, PPIG
5fluvastatin43 49 28 1212.7VCAM1, PPIG
6tcdd439.7KRT10, PPIG
7hydroxyurea43 49 1211.7ITGA4, VCAM1
8cytochalasin d43 5910.7ITGA4, VCAM1
9pravastatin43 49 28 24 1213.7VCAM1, PPIG
10atorvastatin43 49 28 24 1213.5PPIG, VCAM1
11dexamethasone43 49 28 1212.0KRT10, ITGA4, VCAM1, PPIG
12arginine438.6NDP, KRT10, VCAM1

GO Terms for genes affiliated with Venous Insufficiency

About this section

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.1NDP, ITGA4, VCAM1

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chorio-allantoic fusionGO:00607109.8ITGA4, VCAM1
2leukocyte cell-cell adhesionGO:00071599.7ITGA4, VCAM1
3regulation of immune responseGO:00507769.7ITGA4, VCAM1
4heterophilic cell-cell adhesionGO:00071579.6VCAM1, ITGA4
5B cell differentiationGO:00301839.4ITGA4, VCAM1

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:00508399.7ITGA4, VCAM1

Products for genes affiliated with Venous Insufficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Venous Insufficiency

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet