MCID: VNS003
MIFTS: 54

Venous Insufficiency malady

Categories: Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

Aliases & Descriptions for Venous Insufficiency:

Name: Venous Insufficiency 12 29 42 14 69
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 35 459.81
MeSH 42 D014689
SNOMED-CT 64 20696009
ICD10 33 I87.2
UMLS 69 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lupus erythematosus and chronic venous insufficiency. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Nitric Oxide and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Venous insufficiency can refer... more...

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 28.9 CRP PLAT SELP VWF
2 chronic venous insufficiency 12.4
3 post-thrombotic syndrome 11.2
4 lipodermatosclerosis 11.2
5 inflammatory bowel disease 11 10.3 PLAT SERPINE1
6 cerebral calcifications opalescent teeth phosphaturia 10.3 PLAT SERPINE1
7 chromophobe adenoma 10.3 ICAM1 SELL
8 brazilian hemorrhagic fever 10.3 PLAT SERPINE1
9 hypopyon ulcer 10.2 ICAM1 VCAM1
10 tick paralysis 10.2 ICAM1 SELL
11 vcl-related dilated cardiomyopathy 10.2 SELP VWF
12 benign secondary hypertension 10.2 ICAM1 SERPINE1 VCAM1
13 phlegmonous dacryocystitis 10.2 ICAM1 SELL VCAM1
14 chronic fatigue syndrome 10.1 PLAT SERPINE1
15 ependymoblastoma 10.1 ICAM1 SELP VCAM1
16 vaginal endometrial stromal tumor 10.1 ICAM1 SELP VCAM1
17 citrullinemia, type ii, neonatal-onset 10.1 ICAM1 SERPINE1 VCAM1
18 lubinsky syndrome 10.1 F2 SERPINE1
19 monocular exotropia 10.1 PLAT SERPINE1 VWF
20 peanut allergy 10.1 F2 PLAT
21 septic myocarditis 10.1 PLAT SELP VWF
22 nablus mask-like facial syndrome 10.1 ITGAM SELL
23 thyroid cancer, anaplastic 10.1 SELP SERPINE1 VWF
24 orofacial granulomatosis 10.1 ICAM1 MMP1 VCAM1
25 lynch syndrome 10.1 F2 PLAT SERPINE1
26 lymphocytic colitis 10.1 F2 SERPINE1
27 macrodactyly of the foot 10.1 ICAM1 ITGAM VCAM1
28 brill-zinsser disease 10.1 F2 PLAT SERPINE1
29 neuroaxonal dystrophy 10.1 F2 ICAM1 SERPINE1
30 calpainopathy 10.1 ITGAM SELL TIMP1
31 dysgammaglobulinemia 10.1 F2 SELP SERPINE1
32 unilateral multicystic dysplastic kidney 10.1 CRP PLAT
33 pediatric osteosarcoma 10.1 MMP1 SERPINE1 TIMP1
34 sertoli-leydig cell tumor 10.0 F2 PLAT SELP
35 alpha-2-macroglobulin deficiency 10.0 F2 VWF
36 small intestinal l-cell glucagon-like peptide producing tumor 10.0 F2 VWF
37 nodular cutaneous amyloidosis 10.0 MMP1 TIMP1 VWF
38 hennekam lymphangiectasia-lymphedema syndrome 2 10.0 F2 PLAT VWF
39 diffuse large b-cell lymphoma 10.0 CRP MMP1
40 aids dementia complex 10.0 F2 PLAT VWF
41 gait apraxia 10.0 CRP ICAM1 SERPINE1
42 strawberry gallbladder 10.0 CRP ICAM1 SELL
43 hypertension, essential 10.0 PLAT SELP SERPINE1 VWF
44 prostatic hypertrophy 10.0 F2 SELP VWF
45 cardiomyopathy diabetes deafness 10.0 CRP PLAT
46 acute infection of pinna 10.0 CRP F2
47 giant papillary conjunctivitis 10.0 F2 SERPINE1 VWF
48 hodgkin's lymphoma, lymphocytic depletion 10.0 F2 ITGAM
49 atrophic nonflaccid tympanic membrane 10.0 F2 SELP VWF
50 thrombosis 10.0

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Bronchitis
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Femoral Vein Thrombophlebitis Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Iron Deficiency Anemia
Ischemic Heart Disease Left Ventricular Outflow Tract Obstruction
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 CRP F2 ICAM1 PLAT SELL SELP
2 homeostasis/metabolism MP:0005376 10.03 CRP F2 ICAM1 ITGAM MMP1 PLAT
3 hematopoietic system MP:0005397 10.02 SERPINE1 TIMP1 VCAM1 VWF F2 ICAM1
4 immune system MP:0005387 9.93 CRP F2 ICAM1 ITGAM MMP1 PLAT
5 neoplasm MP:0002006 9.35 ICAM1 MMP1 SELL SERPINE1 TIMP1
6 respiratory system MP:0005388 9.1 F2 PLAT SELL SELP SERPINE1 TIMP1

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 390)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
2
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
3
Propranolol Approved, Investigational Phase 4,Phase 3 525-66-6 4946
4
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
7
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Polidocanol Approved Phase 4,Phase 3 9002-92-0
10
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
11
Dalteparin Approved Phase 4,Phase 3,Phase 2 9041-08-1
12
Tinzaparin Approved Phase 4,Phase 3 9005-49-6, 9041-08-1 25244225
13
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
14
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
15
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
17
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
18
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
19
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 1 104987-11-3 445643 439492
20
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
21
Darbepoetin alfa Approved, Investigational Phase 4,Phase 3 11096-26-7, 209810-58-2
22
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
23
Sodium Tetradecyl Sulfate Approved Phase 4 1191-50-0, 139-88-8 14492 5248
24
Furosemide Approved, Vet_approved Phase 4,Early Phase 1 54-31-9 3440
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
26
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
27
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
28
Abatacept Approved Phase 4 332348-12-6 10237
29
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 1,Phase 2 128794-94-5 5281078
30
Mycophenolic acid Approved Phase 4,Phase 1,Phase 2 24280-93-1 446541
31
Chlorothiazide Approved, Vet_approved Phase 4 58-94-6 2720
32
Metolazone Approved Phase 4 17560-51-9 4170
33 tannic acid Approved, Nutraceutical Phase 4,Phase 3
34
Glucosamine Approved, Nutraceutical Phase 4,Early Phase 1 3416-24-8 439213
35
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
36 Adrenergic Agents Phase 4
37 Adrenergic alpha-1 Receptor Antagonists Phase 4
38 Adrenergic alpha-Antagonists Phase 4
39 Adrenergic Antagonists Phase 4
40 Adrenergic beta-Antagonists Phase 4
41 Anti-Arrhythmia Agents Phase 4
42 Antihypertensive Agents Phase 4
43 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Early Phase 1
44 Vasodilator Agents Phase 4,Phase 2
45 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
46 Coagulants Phase 4,Phase 3
47 Hemostatics Phase 4,Phase 3
48 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
50 calcium heparin Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 542)
id Name Status NCT ID Phase
1 Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings Unknown status NCT01793194 Phase 4
2 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
3 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
4 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Unknown status NCT01059396 Phase 4
5 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4
6 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4
7 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4
8 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4
9 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4
10 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
11 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
12 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
13 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
14 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
15 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4
16 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4
17 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
18 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
19 Comparison of Effectiveness and Safety of Three Lock Solutions for Long-Term Central Venous Catheter for Hemodialysis Completed NCT02618317 Phase 4
20 Pharmacokinetics of Dalteparin in Patients With Impaired Renal Function Completed NCT00264693 Phase 4
21 Innohep® in Elderly Patients With Impaired Renal Function Treated for Acute Deep Vein Thrombosis Completed NCT00277394 Phase 4
22 Prospective, Multicentre, Open-label Study Evaluating 1.5 mg/Day of Fondaparinux. Completed NCT00555438 Phase 4
23 Skin Ulcers Treatment With an Handicraft Topical Device Completed NCT02512159 Phase 4
24 Dose-finding of Rivaroxaban in Hemodialysis Completed NCT02047006 Phase 4
25 A Study of Routine Versus Selective Use of Ultrasound Scanning Prior to Haemodialysis Fistula Surgery Completed NCT01004627 Phase 4
26 Pharmacokinetics of Ertapenem in Patients Aged Over 75 Completed NCT02505386 Phase 4
27 Fondaparinux in Critically Ill Patients With Renal Failure Completed NCT01467583 Phase 4
28 Product Evaluation for the Effectiveness of the ClearGuard™ HD End Cap Completed NCT02604264 Phase 4
29 Antifungal Locks to Treat Fungal-related Central Line Infections Completed NCT00936910 Phase 4
30 Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF). Completed NCT00221013 Phase 4
31 Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate Completed NCT01184989 Phase 4
32 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4
33 Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation Completed NCT00629122 Phase 4
34 Hannover Dialysis Outcome Study Completed NCT00529139 Phase 4
35 The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas Completed NCT01685710 Phase 4
36 An Observational Study of Case Managed Versus Non-case Managed Initiation of Hemodialysis Completed NCT01613404 Phase 4
37 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4
38 Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. Completed NCT01041755 Phase 4
39 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Recruiting NCT02236338 Phase 4
40 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Recruiting NCT02248740 Phase 4
41 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4
42 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Recruiting NCT02512601 Phase 4
43 Safety Study of Enoxaparin Prophylaxis in Critically Ill Adults With Severe Renal Insufficiency Recruiting NCT02690090 Phase 4
44 Heterotopic Implantation Of the Edwards-Sapien XT Transcatheter Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
45 Enoxaparin 20mg Versus 30mg Subcutaneously Once Daily in Elderly Patients With Impaired Renal Function Recruiting NCT03158792 Phase 4
46 Loop Diuretic Dosage in Patients With Acute Heart Failure and Renal Failure: Conventional Versus Carbohydrate Antigen 125-guided Therapy (IMPROVE-HF) Recruiting NCT02643147 Phase 4
47 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
48 Phosphate Lowering to Treat Vascular Dysfunction in Chronic Kidney Disease Recruiting NCT02209636 Phase 4
49 Belatacept in Kidney Transplantation of Moderately Sensitized Patients Recruiting NCT02130817 Phase 4
50 Lake Washington Vascular VenaSeal™ Post-Market Evaluation (WAVES) Active, not recruiting NCT02585726 Phase 4

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

id Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

39
Skin, Endothelial, Brain, Heart, Testes, Neutrophil, Breast

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 619)
id Title Authors Year
1
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
2
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
3
Erratum: Chronic cerebrospinal venous insufficiency: the end of "The Big Idea"? ( 27110450 )
2016
4
Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression. ( 26946890 )
2016
5
Dehydrated Human Amnion/Chorion Grafts May Accelerate the Healing of Ulcers on Free Flaps in Patients With Venous Insufficiency and/or Lymphedema. ( 27648116 )
2016
6
Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don't tell, they won't know. ( 27982166 )
2016
7
Venous compression syndrome of internal jugular veins prevalence in patients with multiple sclerosis and chronic cerebro-spinal venous insufficiency. ( 27842009 )
2016
8
Compression in the treatment of chronic venous insufficiency: Efficacy depending on the length of the stocking. ( 27886005 )
2016
9
The effects of short-term use of compression stockings on health related quality of life in patients with chronic venous insufficiency. ( 27512248 )
2016
10
Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. ( 27914110 )
2016
11
Primary venous insufficiency increases risk of deep vein thrombosis. ( 26993861 )
2016
12
Distally based subcutaneous veins for venous insufficiency of the reverse posterior interosseous artery flap. ( 27002589 )
2016
13
Response to letter regarding Embolization is not essential in the treatment of leg varices due to pelvic venous insufficiency. ( 27380947 )
2016
14
Popliteal vein external banding at the valve-free segment to treat severe chronic venous insufficiency. ( 27131925 )
2016
15
Frequency of Peripheral Arterial Disease in Patients With Chronic Venous Insufficiency. ( 26889387 )
2016
16
Venous flow during manual lymphatic drainage applied to different regions of the lower extremity in people with and without chronic venous insufficiency: a cross-sectional study. ( 27083323 )
2016
17
Technique, Efficiency and Safety of Different Nerve Blocks for Analgesia in Laser Ablation and Sclerotherapy for Lower Limb Superficial Venous Insufficiency - A Multicentre Experience. ( 28050474 )
2016
18
Endovenous laser ablation versus mechanochemical ablation with ClariVein(Ar) in the management of superficial venous insufficiency (LAMA trial): study protocol for a randomised controlled trial. ( 27552990 )
2016
19
Phlebotonics for venous insufficiency. ( 27048768 )
2016
20
Letter regarding embolization is not essential in the treatment of leg varices due to pelvic venous insufficiency. ( 27151535 )
2016
21
A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency. ( 26916777 )
2016
22
The Impact of Race on Advanced Chronic Venous Insufficiency. ( 27179983 )
2016
23
TCT-772 High prevalence of pelvic venous compression syndrome among patients with chronic venous insufficiency and effective treatment with venous stenting. ( 27970159 )
2016
24
N-butyl cyanoacrylate in the treatment of venous insufficiency - the effect of embolisation with ablative polymerisation. ( 27129070 )
2016
25
Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases. ( 27846752 )
2016
26
Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency. ( 27329669 )
2016
27
Advantages and disadvantages of graduated and inverse graduated compression hosiery in patients with chronic venous insufficiency and healthy volunteers: A prospective, mono-centric, blinded, open randomised, controlled and cross-over trial. ( 27932625 )
2016
28
Percutaneous Iliocaval Construction to Treat Symptomatic Chronic Lower Extremity Venous Insufficiency. ( 27449977 )
2016
29
Progressive compression versus graduated compression for the management of venous insufficiency. ( 27594309 )
2016
30
Lipomembranous Panniculitis Associated With Venous Insufficiency, Morphea, and Psoriasis. ( 27319959 )
2016
31
The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction. ( 26924360 )
2016
32
The Prevalence of Chronic Cerebrospinal Venous Insufficiency in Meniere Disease: 24-Month Follow-up after Angioplasty. ( 28034701 )
2016
33
Social Media Representation of Chronic Cerebrospinal Venous Insufficiency Intervention for Multiple Sclerosis. ( 27134577 )
2016
34
Doppler ultrasound study and venous mapping in chronic venous insufficiency. ( 26655801 )
2016
35
Effect of socio-demographic characteristics and clinical findings on the quality of life of patients with chronic venous insufficiency. ( 28007012 )
2016
36
Extracranial Venous Drainage Pattern in Multiple Sclerosis and Healthy Controls: Application of the 2011 Diagnostic Criteria for Chronic Cerebrospinal Venous Insufficiency. ( 27384420 )
2016
37
Sulodexide suppresses inflammation in patients with chronic venous insufficiency. ( 26044841 )
2015
38
Clinical features of venous insufficiency and the risk of venous thrombosis in older people. ( 26221838 )
2015
39
No Association of Chronic Cerebrospinal Venous Insufficiency with Multiple Sclerosis. ( 26194114 )
2015
40
A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. ( 25991692 )
2015
41
Pregnancy-dependent blood flow velocity changes in lower extremities veins in venous insufficiency. ( 26665566 )
2015
42
Postoperative Venous Insufficiency in Microsurgical Lower Extremity Reconstruction and Deep Vein Thrombosis Potential as Assessed by a Caprini Risk Assessment Model. ( 26182176 )
2015
43
Embolization is essential in the treatment of leg varicosities due to pelvic venous insufficiency. ( 25729072 )
2015
44
A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. ( 25630350 )
2015
45
Adherence to and efficacy of different compression methods for treating chronic venous insufficiency in the elderly. ( 26518327 )
2015
46
New acoustic wave therapy improves quality of life in patients with multiple sclerosis and chronic cerebrospinal venous insufficiency. ( 26343352 )
2015
47
In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency. ( 26316151 )
2015
48
Embolization is not essential in the treatment of leg varices due to pelvic venous insufficiency. ( 25729073 )
2015
49
A new option for endovascular treatment of leg ulcers caused by venous insufficiency with fluoroscopically guided sclerotherapy. ( 26649090 )
2015
50
Quality of life in patients with venous stasis ulcers and others with advanced venous insufficiency. ( 25658932 )
2015

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 F2 ICAM1 ITGAM MMP1 SERPINE1 VCAM1
2
Show member pathways
13.16 ICAM1 ITGAM MMP1 TIMP1 VCAM1 VWF
3
Show member pathways
12.56 ICAM1 ITGAM MMP1 SERPINE1 TIMP1 VCAM1
4
Show member pathways
12.35 F2 ITGAM MMP1 PLAT SELL SELP
5
Show member pathways
12.19 CRP F2 ICAM1 PLAT SERPINE1
6
Show member pathways
12.02 F2 PLAT SERPINE1 VWF
7
Show member pathways
12.02 F2 ITGAM MMP1 SELL SELP
8
Show member pathways
11.97 ICAM1 ITGAM VCAM1 VWF
9 11.94 ICAM1 PLAT VCAM1
10 11.92 ICAM1 SELL VCAM1
11 11.82 ICAM1 ITGAM SELL SELP VCAM1
12 11.81 ICAM1 SERPINE1 VCAM1
13 11.74 ICAM1 SERPINE1 VCAM1
14 11.7 F2 ITGAM PLAT SERPINE1 VWF
15
Show member pathways
11.53 ICAM1 MMP1 VCAM1
16 11.49 MMP1 PLAT SERPINE1 TIMP1
17 11.47 ICAM1 ITGAM SELP
18 11.41 ICAM1 ITGAM MMP1 TIMP1 VCAM1
19 11.4 ICAM1 SELP VCAM1
20 11.34 ICAM1 ITGAM VCAM1
21 11.3 ICAM1 ITGAM PLAT SELP
22
Show member pathways
11.11 CRP TIMP1
23 11.05 F2 ICAM1 TIMP1
24 10.95 F2 MMP1
25 10.9 MMP1 TIMP1
26 10.8 ICAM1 VCAM1
27 10.7 PLAT SERPINE1

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.95 CRP F2 MMP1 PLAT SERPINE1 TIMP1
2 extracellular exosome GO:0070062 9.91 CRP F2 ICAM1 ITGAM PLAT SERPINE1
3 cell surface GO:0009986 9.72 ICAM1 ITGAM PLAT SELL VCAM1
4 extracellular matrix GO:0031012 9.55 MMP1 PLAT SERPINE1 TIMP1 VWF
5 platelet alpha granule lumen GO:0031093 9.54 SERPINE1 TIMP1 VWF
6 external side of plasma membrane GO:0009897 9.35 F2 ICAM1 SELL SELP VCAM1
7 extracellular space GO:0005615 9.28 CRP F2 ICAM1 ITGAM PLAT SELP

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.8 ICAM1 ITGAM SELL SELP VCAM1 VWF
2 response to hypoxia GO:0001666 9.72 ICAM1 PLAT VCAM1
3 platelet degranulation GO:0002576 9.67 SELP SERPINE1 TIMP1 VWF
4 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELP VCAM1
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 ICAM1 SERPINE1
6 negative regulation of proteolysis GO:0045861 9.54 F2 PLAT
7 blood coagulation, intrinsic pathway GO:0007597 9.52 F2 VWF
8 calcium-mediated signaling using intracellular calcium source GO:0035584 9.51 SELP VCAM1
9 leukocyte tethering or rolling GO:0050901 9.49 SELP VCAM1
10 positive regulation of blood coagulation GO:0030194 9.48 F2 SERPINE1
11 negative regulation of fibrinolysis GO:0051918 9.46 F2 SERPINE1
12 membrane to membrane docking GO:0022614 9.43 ICAM1 VCAM1
13 leukocyte cell-cell adhesion GO:0007159 9.43 ICAM1 SELP VCAM1
14 extracellular matrix organization GO:0030198 9.35 ICAM1 ITGAM SERPINE1 VCAM1 VWF
15 fibrinolysis GO:0042730 9.33 F2 PLAT SERPINE1
16 leukocyte migration GO:0050900 9.1 F2 ICAM1 ITGAM MMP1 SELL SELP

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.5 F2 SELL SELP
2 integrin binding GO:0005178 9.43 ICAM1 VCAM1 VWF
3 lipopolysaccharide binding GO:0001530 9.37 F2 SELP
4 protease binding GO:0002020 9.26 SELL SERPINE1 TIMP1 VWF
5 glycosphingolipid binding GO:0043208 9.16 SELL SELP
6 glycoprotein binding GO:0001948 8.92 ITGAM PLAT SELP VWF

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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