MCID: VNS003
MIFTS: 52

Venous Insufficiency malady

Cardiovascular category

Summaries for Venous Insufficiency

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Venous insufficiency can refer to: more...

MalaCards: Venous Insufficiency, also known as peripheral venous insufficiency, is related to arteriosclerosis and arteriosclerosis obliterans. An important gene associated with Venous Insufficiency is ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)), and among its related pathways are Malaria and Rheumatoid arthritis. The drugs gotu kola extract and gotu kola liquid and the compounds indomethacin and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Venous Insufficiency

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

venous insufficiency 8 10 61
peripheral venous insufficiency 8


External Ids:

Disease Ontology8 DOID:10128
MeSH35 D014689
SNOMED-CT57 20696009
ICD9CM27 459.81
ICD1025 I87.2

Related Diseases for Venous Insufficiency

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis29.9VCAM1
2arteriosclerosis obliterans29.9VCAM1
3vascular disease29.9ITGAM, SELL, PLAU
4tuberculosis29.9SELL, ITGAL, ITGB2, ITGAM
5systemic lupus erythematosus29.9ITGAM, VCAM1, ITGA4, ITGAL, ITGB2
6vasculitis29.9ITGAM, SELL, VCAM1, ITGAX, ITGA4, ITGB2
7varicose veins10.5
8venous thrombosis10.4
9necrobiosis lipoidica10.3
10chronic pain10.3
11lipodermatosclerosis10.2
12norrie disease10.2
13klippel-trenaunay syndrome10.1
14type i ehlers-danlos syndrome10.1
15crohn's disease10.0ITGA4
16peritonitis10.0ITGB2
17sarcoidosis10.0ITGAM
18rhinitis10.0VCAM1
19barrett's esophagus10.0GLTP
20lung cancer10.0PLAU
21multiple myeloma10.0ITGA4
22leukopenia10.0ITGAM
23hepatitis10.0SELL
24encephalomyelitis10.0ITGA4, VCAM1
25ischemia10.0ITGAL, ITGB2
26dermatitis10.0ITGB2, VCAM1
27diabetic retinopathy10.0SELL, VCAM1
28sjogren's syndrome10.0ITGAL
29proteinuria10.0ITGB2
30gastrointestinal system disease10.0CLDN1
31peripheral vascular disease10.0
32pulmonary tuberculosis10.0
33acrodermatitis10.0
34menkes disease10.0
35klinefelter's syndrome10.0
36porphyria cutanea tarda10.0
37digeorge syndrome10.0
38arachnoiditis10.0
39cadasil10.0
40thromboangiitis obliterans10.0
41hyperhomocysteinemia10.0
42localized scleroderma10.0
43kaposi's sarcoma10.0
44vitiligo10.0
45thoracic outlet syndrome10.0
46blood platelet disease10.0
47thrombophilia10.0
48thrombophlebitis10.0
49vein disease10.0
50ehlers-danlos syndrome, classic type10.0

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to venous insufficiency

Clinical Features for Venous Insufficiency

Drugs & Therapeutics for Venous Insufficiency

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Venous Insufficiency

Drug clinical trials:

Search ClinicalTrials for Venous Insufficiency

Search NIH Clinical Center for Venous Insufficiency

Search CenterWatch for Venous Insufficiency

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Venous Insufficiency

Anatomical Context for Venous Insufficiency

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Venous Insufficiency:

33
Skin, Brain, Heart, Breast, Monocytes, T cells, Endothelial, Fetal brain

Animal Models for Venous Insufficiency or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Venous Insufficiency

Sources:
51PubMed
See all sources

Articles related to Venous Insufficiency:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Elephantiasis nostras verrucosa in a patient with obesity and chronic venous insufficiency. (23432135)
2013
2
Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study. (24014572)
2013
3
PycnogenolAr in Chronic Venous Insufficiency and Related Venous Disorders. (23775628)
2013
4
Percutaneous angioplasty of internal jugular and azygous veins in patients with chronic cerebrospinal venous insufficiency and multiple sclerosis: early and mid-term results. (23563645)
2013
5
Assessment of jugular endovascular malformations in chronic cerebrospinal venous insufficiency: colour-Doppler scanning and catheter venography compared with intravascular ultrasound. (23155132)
2013
6
Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis. (23866161)
2013
7
Mystery of chronic cerebrospinal venous insufficiency: identical venographic and ultrasound findings in patients with MS and controls. (23370468)
2013
8
Autonomic dysfunction: a unifying multiple sclerosis theory, linking chronic cerebrospinal venous insufficiency, vitamin D(3), and Epstein-Barr virus. (22564548)
2012
9
Chronic cerebrospinal venous insufficiency in multiple sclerosis: fact or fiction!? Comment on Dr. Jim Reeker's reply. (22006027)
2012
10
No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis. (22513520)
2012
11
Possible pathomechanisms responsible for injury to the central nervous system in the settings of chronic cerebrospinal venous insufficiency. (22356241)
2012
12
Brain hemodynamic changes associated with chronic cerebrospinal venous insufficiency are not specific to multiple sclerosis and do not increase its severity. (22915599)
2012
13
Saphenous pulsation on duplex may be a marker of severe chronic superficial venous insufficiency. (22796335)
2012
14
Does venous insufficiency impair the exercise-induced rise in arterial leg blood flow? (21937517)
2011
15
Chronic cerebrospinal venous insufficiency: have we found the cause and cure of MS? (21490321)
2011
16
Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers. (22140507)
2011
17
Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. (22105958)
2011
18
Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis. (22021635)
2011
19
Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis. (22364941)
2011
20
Chronic cerebrospinal venous insufficiency and multiple sclerosis. (20373339)
2010
21
The incidence of raised procoagulant factors and hyperhomocysteinaemia in Chinese patients with chronic venous insufficiency. (20456987)
2010
22
Innovative treatments in chronic venous insufficiency: endovenous laser ablation of perforating veins: a prospective short-term analysis of 58 cases. (20547462)
2010
23
Clinical presentation and patterns of venous reflux in Thai patients with chronic venous insufficiency (CVI). (20561800)
2010
24
Acroangiodermatitis secondary to chronic venous insufficiency. (21214123)
2010
25
Leg ulceration in chronic venous insufficiency caused by an absent inferior vena cava. (19734977)
2009
26
Is total abolishment of great saphenous reflux in the invasive treatment of superficial chronic venous insufficiency always necessary? (19190549)
2009
27
Endothelial function impairment in chronic venous insufficiency: effect of some cardiovascular protectant agents. (19240105)
2009
28
Recommended reporting standards for endovenous ablation for the treatment of venous insufficiency: joint statement of the American Venous Forum and the Society of Interventional Radiology. (19560029)
2009
29
Cutaneous vasomotion in patients with chronic venous insufficiency and the influence of compression therapy. (19136743)
2009
30
Venous insufficiency and foot dysmorphism: effectiveness of visco-elastic rehabilitation systems on veno-muscle system of the foot and of the calf. (19887035)
2009
31
Impact of lower extremity venous ulcers due to chronic venous insufficiency on quality of life. (19430523)
2008
32
Initial experience of subfascial endoscopic perforator vein surgery in patients with severe chronic venous insufficiency. (17966938)
2007
33
Testing of a HIFU probe for the treatment of superficial venous insufficiency by using MRI. (17945783)
2006
34
Comparison of manual compression release with distal pneumatic cuff maneuver in the ultrasonic evaluation of superficial venous insufficiency. (16750921)
2006
35
Radionuclide assessment of the treatment by compression of patients with chronic venous insufficiency. (16474294)
2005
36
Imaging of venous insufficiency. (21326691)
2005
37
Endovenous laser treatment combined with a surgical strategy for treatment of venous insufficiency in lower extremity: a report of 208 cases. (16171594)
2005
38
Quality of life in chronic venous insufficiency. An Italian pilot study of the Triveneto Region. (16158038)
2005
39
Treatment of lower extremity venous insufficiency due to pelvic leak points in women. (15770361)
2005
40
Efficacy of topical treatment with aescin + essential phospholipids gel in a microcirculatory model of venous insufficiency. (15156252)
2004
41
Endovenous laser ablation of the saphenous vein for treatment of venous insufficiency and varicose veins: early results from a large single-center experience. (15056020)
2004
42
Chronic venous insufficiency of the lower limbs: suitability of transcutaneous blood gas monitoring as an endpoint to evaluate the outcome of pharmacological treatment with calcium dobesilate. (15672120)
2004
43
Efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension. (15156253)
2004
44
Non-invasive monitoring of compression therapy: a report of three cases with venous insufficiency. (12575856)
2002
45
Venous stasis ulcers due to primary, isolated deep venous insufficiency in a patient with systemic lupus erythematosus: report of a case. (12376799)
2002
46
Lower limb venous insufficiency and tobacco smoking: a case-control study. (12034579)
2002
47
Platelet-monocyte aggregates in patients with chronic venous insufficiency remain elevated following correction of reflux. (12379404)
2002
48
Role of ultrasound in the assessment of chronic venous insufficiency. (12973085)
2001
49
Increased expression of platelet-derived growth factor receptor alpha and beta and vascular endothelial growth factor in the skin of patients with chronic venous insufficiency. (9705159)
1998
50
Scintigraphic demonstration of lower extremity periostitis secondary to venous insufficiency. (3164753)
1988

Genetic Variations for Venous Insufficiency

Expression for genes affiliated with Venous Insufficiency

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for genes affiliated with Venous Insufficiency

Sources:
30KEGG, 4Cell Signaling Technology, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Venous Insufficiency according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3ITGAL
210.2ITGB2, ITGAL
310.2ITGA4, CLDN1, VCAM1
4
Hide members
10.1ITGAL, ITGB2, ITGA4
510.1TGFB3, ITGB2, ITGAM
610.0ITGB2, PLAU, ITGAM
7
Immune response Lectin induced complement pathway
Hide members
10.0ITGAM, ITGB2, ITGAX
810.0CLDN1, CLDN3, CLDN5
910.0ITGAL, ITGAX, ITGAM
10
Hide members
10.0ITGB2, ITGAL, ITGA4, VCAM1
11
Hide members
10.0ITGAM, ITGA4, TGFB3, ITGB2
129.9ITGAL, KRT10, ITGB2, ITGAM
13
Hide members
9.9P2RY1, PLAU, SELL, TGFB3
149.9ITGAM, ITGB2, ITGAX, TGFB3
15
Hide members
9.9CLDN3, KRT14, CLDN1, CLDN5
169.8ITGA4, ITGB2, VCAM1, ITGAL, ITGAM
179.8ITGB2, VCAM1, ITGAL, TGFB3, PDGFRB
18
Hide members
9.7ITGA4, ITGAM, ITGAL, ITGAX, ITGB2
19
Hide members
9.7ITGAM, ITGA4, ITGAL, ITGB2, ITGAX
20
Hide members
9.7ITGA4, ITGAM, ITGAL, ITGAX, ITGB2
219.7ITGAX, ITGAM, ITGA4, ITGB2, ITGAL
22
Hide members
9.7ITGAL, ITGAX, ITGB2, ITGAM, ITGA4
239.7ITGAL, ITGAX, ITGB2, ITGA4, ITGAM
249.6ITGAX, SELL, ITGB2, ITGAM, ITGA4, ITGAL
25
Hide members
9.6PDGFRB, ITGA4, ITGAM, ITGB2, ITGAX, ITGAL
26
Hide members
9.6PDGFRB, ITGAM, ITGB2, ITGAL, ITGAX, ITGA4
27
Hide members
9.6ITGAX, ITGAL, ITGB2, ITGAM, ITGA4, PDGFRB
28
Hide members
9.6ITGAX, ITGAL, ITGA4, PDGFRB, ITGAM, ITGB2
29
Hide members
9.5ITGA4, ITGAM, ITGB2, ITGAX, TGFB3, VCAM1
30
Hide members
9.5ITGB2, ITGAL, ITGAX, ITGAM, ITGA4, TGFB3
31
Hide members
9.5ITGA4, PDGFRB, ITGB2, ITGAM, ITGAL, ITGAX
32
Hide members
9.5ITGAL, ITGAM, ITGAX, TGFB3, PDGFRB, ITGB2
339.4ITGB2, ITGAL, CLDN5, CLDN3, CLDN1, ITGAM
34
Hide members
9.3ITGAX, ITGAL, VCAM1, ITGB2, ITGAM, ITGA4
35
Hide members
9.3ITGB2, PLAU, PDGFRB, ITGA4, ITGAM, ITGAL
36
Hide members
9.3PDGFRB, TGFB3, P2RY1, ITGAL, ITGB2, ITGAX
37
Hide members
9.3CLDN1, CLDN5, CLDN3, ITGB2, ITGA4, ITGAM
389.2ITGB2, ITGAL, CLDN5, ITGAM, ITGA4, CLDN3
39
Hide members
9.0ITGA4, ITGAM, ITGB2, ITGAL, CLDN5, ITGAX

Compounds for genes affiliated with Venous Insufficiency

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Venous Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1indomethacin45 60 29 1113.5PLAU
2butyrate4510.5ITGAX, ITGAL
3slea4510.4SELL, ITGAL, ITGA4
4polyacrylonitrile4510.4ITGAL, ITGB2, ITGAM
5polysulfone4510.3ITGAM, ITGB2, SELL, VCAM1
6cycloheximide4510.3ITGAX, ITGAM, SELL
7serine4510.3ITGA4, KRT14, ITGB2, ITGAM
8pentoxifylline45 1111.3ITGA4, VCAM1, SELL, ITGB2, ITGAM
9cuprophan4510.2VCAM1, ITGAL, ITGB2, ITGAM, SELL
10rantes4510.2ITGA4, SELL, ITGAL, ITGB2, ITGAM
11prednisolone45 29 1112.2SELL, VCAM1, ITGAL, ITGB2, ITGAM
12slex4510.1ITGAM, SELL, ITGB2, ITGAL, ITGA4, VCAM1
13n-formylmethionyl-leucylphenylalanine4510.1ITGAM, ITGAL, ITGAX, SELL, ITGB2
14leukotriene b445 60 2412.1ITGB2, ITGAX, SELL, ITGAL, ITGAM
15simvastatin45 50 60 29 11 2415.1ITGB2, SELL, VCAM1, ITGAL, ITGAM
16endotoxin4510.1ITGB2, ITGAL, ITGAM, VCAM1, SELL
17isoproterenol45 1111.1ITGAM, SELL, VCAM1, ITGB2, ITGAL
18cytochalasin d45 6011.1VCAM1, SELL, ITGAX, ITGAL, ITGB2, ITGA4
19sphingosine45 11 2412.1VCAM1, PDGFRB, ITGAL, GLTP, PLAU
20retinoid4510.0ITGB2, PLAU, ITGAM, KRT14, KRT10, SELL
21lovastatin45 50 60 29 1114.0PDGFRB, ITGAL, ITGAM, ITGB2
22oxygen45 2411.0ITGA4, ITGAL, ITGAX, ITGAM, SELL, TGFB3
23phorbol-12-myristate4510.0SELL, ITGAM, ITGAX, ITGB2, PLAU, ITGAL
24calcitriol45 60 11 2413.0KRT10, PLAU, ITGAM, ITGAL, PDGFRB
25phorbol4510.0ITGB2, SELL, ITGAL, ITGAM, PLAU, ITGAX
26heparin45 29 11 2413.0SELL, VCAM1, ITGAL, ITGB2, ITGAM, ITGA4
27paraffin4510.0SELL, KRT10, KRT14, PLAU, PDGFRB, TGFB3
28aspirin45 50 29 2413.0PLAU, P2RY1, ITGAM, SELL, ITGAL
29genistein45 29 60 2 11 2414.9SELL, VCAM1, PLAU, PDGFRB, ITGB2, ITGA4
30fmlp459.9VCAM1, ITGAL, ITGA4, ITGAM, ITGAX, ITGB2
31sb 20358045 6010.9ITGB2, PLAU, ITGAM, VCAM1, SELL
32polysaccharide459.9ITGAM, ITGB2, SELL, VCAM1, PLAU
33atorvastatin45 50 29 11 2413.8PLAU, SELL, VCAM1, ITGAM
34superoxide45 2410.8ITGAX, ITGB2, SELL, ITGAM, ITGAL, VCAM1
35dexamethasone45 50 29 1112.8ITGAM, ITGB2, KRT10, SELL, ITGAL, VCAM1
36wortmannin459.8ITGAL, PLAU, VCAM1, ITGAM, P2RY1, ITGA4
37vitamin d459.8ITGAM, PDGFRB, ITGB2, KRT14, KRT10
38fibrinogen459.8PLAU, ITGB2, P2RY1, ITGA4, ITGAX, ITGAM
39phosphatidylinositol459.7VCAM1, PDGFRB, P2RY1, ITGAL, ITGB2, ITGAM
40vegf459.7PLAU, ITGAM, VCAM1, CLDN3, ITGB2, PDGFRB
41nitric oxide45 11 2411.7P2RY1, VCAM1, ITGAX, ITGB2, ITGAM, ITGA4
42alanine459.7SELL, ITGB2, VCAM1, KRT14, PDGFRB, PLAU
43cholesterol45 29 11 2412.7PDGFRB, ITGAL, VCAM1, KRT14, CLDN3, GLTP
44cysteine459.7NDP, PLAU, PDGFRB, ITGAM, ITGB2, ITGAL
45h2o2459.6ITGAM, ITGB2, ITGAL, SELL, PLAU, PDGFRB
46histamine45 29 2411.5PLAU, ITGAM, SELL, ITGB2, VCAM1
47lipid459.5P2RY1, KRT14, VCAM1, ITGAL, ITGB2, ITGAM
48tyrosine459.3SELL, ITGAM, VCAM1, KRT10, TGFB3, KRT14
49retinoic acid45 2410.3ITGAM, PDGFRB, ITGA4, ITGB2, ITGAL, VCAM1
50calcium45 50 11 2412.2P2RY1, ITGAL, PDGFRB, ITGA4, ITGAM, ITGB2

GO Terms for genes affiliated with Venous Insufficiency

Sources:
16Gene Ontology
See all sources

Cellular components related to Venous Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.0CLDN1, CLDN3, CLDN5
2integrin complexGO:0083059.8ITGAX, ITGAL, ITGB2, ITGAM, ITGA4
3external side of plasma membraneGO:0098979.6ITGA4, ITGAM, ITGAL, ITGAX, VCAM1, SELL
4cell surfaceGO:0099869.6NDP, ITGA4, PLAU, VCAM1, TGFB3
5plasma membraneGO:0058868.6PDGFRB, ITGA4, ITGAM, ITGB2, ITGAL, ITGAX

Biological processes related to Venous Insufficiency according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1chorio-allantoic fusionGO:06071010.3VCAM1, ITGA4
2heterophilic cell-cell adhesionGO:00715710.3VCAM1, ITGAL, ITGA4
3calcium-independent cell-cell adhesionGO:01633810.2CLDN5, CLDN3, CLDN1
4activated T cell proliferationGO:05079810.2ITGAL, ITGAM
5leukocyte cell-cell adhesionGO:00715910.1ITGA4, ITGAM, ITGB2, ITGAL, VCAM1
6agingGO:00756810.1TGFB3, VCAM1, P2RY1
7regulation of receptor activityGO:01046910.1P2RY1, PLAU
8regulation of immune responseGO:05077610.1ITGA4, ITGB2, ITGAL, VCAM1, SELL
9response to hypoxiaGO:00166610.0CLDN3, PLAU, VCAM1, TGFB3
10integrin-mediated signaling pathwayGO:00722910.0ITGA4, ITGAM, ITGB2, ITGAL, ITGAX
11regulation of peptidyl-tyrosine phosphorylationGO:0507309.9ITGB2, PDGFRB
12leukocyte migrationGO:0509009.9ITGA4, ITGAM, ITGB2, ITGAL, ITGAX, SELL
13cell adhesionGO:0071559.7ITGAM, ITGB2, ITGAL, ITGAX, CLDN1, VCAM1
14blood coagulationGO:0075969.4TGFB3, ITGA4, ITGAM, ITGB2, ITGAL, ITGAX

Molecular functions related to Venous Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.1SELL, VCAM1, ITGAL

Products for genes affiliated with Venous Insufficiency

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venous Insufficiency

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet