MCID: VNS010
MIFTS: 55

Venous Thromboembolism malady

Blood diseases category
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Summaries for Venous Thromboembolism

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CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

MalaCards based summary: Venous Thromboembolism is related to thromboembolism and patent foramen ovale. An important gene associated with Venous Thromboembolism is HABP2 (hyaluronan binding protein 2), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Selected targets of HNF1. The compounds inogatran and organon have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related mouse phenotypes are reproductive system and embryogenesis.

Wikipedia:65 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

Description from OMIM:46 188050

Aliases & Classifications for Venous Thromboembolism

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Venous Thromboembolism, Aliases & Descriptions:

Name: Venous Thromboembolism 46 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Related Diseases for Venous Thromboembolism

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Diseases related to Venous Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism31.0FGA, F5, F2, HABP2, F10, APOH
2patent foramen ovale30.9F5
3afibrinogenemia30.7FGA
4eclampsia30.7MTHFR, SERPINC1
5homocysteinemia30.7F5, MTHFR
6thrombophlebitis30.6APOH, F8
7hyperhomocysteinemia30.6F2, APOH, SERPINC1, MTHFR, F8, F5
8vascular disease30.4APOH, SERPINC1, F3, F8
9hypertension30.4F2, MTHFR, F5
10factor xi deficiency30.4F5, F8, F3, F2
11antithrombin iii deficiency30.3F10, APOH, SERPINC1, MTHFR, F5, F2
12protein c deficiency30.3F5, MTHFR, PROCR, F2, APOH, SERPINC1
13thrombocytosis30.3F2, F10, SERPINC1, F3, FGA
14liver cirrhosis30.3FGA, SERPINC1, F2
15portal vein thrombosis30.2F2, SERPINC1, MTHFR, F8, F5
16acute myocardial infarction30.2F10, SERPINC1, F3, FGA
17vasculitis30.2F2, APOH, FGA
18pulmonary embolism30.1F2, F10, APOH, SERPINC1, F3, MTHFR
19proteinuria30.0FGA, APOH, APOA4
20thrombophilia30.0F10, APOH, SERPINC1, SERPINA10, PROC, PROCR
21lupus erythematosus30.0F2, APOH, SERPINC1, PROCR, F3, F5
22thrombocytopenia30.0F3, SERPINC1, APOH, F10, F2, F8
23protein s deficiency29.8F2, APOH, SERPINC1, F3, MTHFR, F8
24antiphospholipid syndrome29.7F5, F8, F2, F10, APOH, SERPINC1
25leukemia29.7F10, MTHFR, F8, LTC4S, FGA
26systemic lupus erythematosus29.6F2, F10, APOH, PROCR, F3, F8
27venous thrombosis29.3F2, F10, APOH, SERPINC1, SERPINA10, PROC
28sepsis29.3FGA, F5, F3, PROCR, PROC, CPB2
29myocardial infarction29.2SERPINC1, PROCR, F3, P2RY12, MTHFR, F8
30pre-eclampsia29.2F2, F10, APOH, SERPINC1, F3, MTHFR
31atherosclerosis28.7HABP2, APOA4, APOH, SERPINC1, PROCR, F3
32cerebrovascular disease28.3MTHFR, F8, VKORC1, F5, FGA, P2RY12
33purpura10.6SERPINC1
34branch retinal artery occlusion10.6F5
35endotheliitis10.6
36obesity10.5
37carotid artery thrombosis10.5F3
38retinal artery occlusion10.5APOH
39sagittal sinus thrombosis10.5SERPINC1, F5
40colorectal cancer10.5
41inflammatory bowel disease10.5
42post-thrombotic syndrome10.4SERPINC1, F5
43coronary thrombosis10.4F3, SERPINC1
44legg-calve-perthes disease10.4SERPINC1, F5
45warfarin resistance10.4VKORC1
46hypersplenism10.4F2
47factor xii deficiency10.4F3, F5
48inherited hypoprothrombinemia10.4F10, F2
49lung cancer10.4
50endocarditis10.4F10

Graphical network of the top 20 diseases related to Venous Thromboembolism:



Diseases related to venous thromboembolism

Symptoms for Venous Thromboembolism

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Clinical features from OMIM:

188050

Drugs & Therapeutics for Venous Thromboembolism

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Drug clinical trials:

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Search NIH Clinical Center for Venous Thromboembolism

Genetic Tests for Venous Thromboembolism

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Anatomical Context for Venous Thromboembolism

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MalaCards organs/tissues related to Venous Thromboembolism:

32
Lung, Testes, Endothelial, Heart, Brain, Liver, Breast, Kidney, Lymph node, Ovary, B cells, Bone, Spinal cord, Skin, Neutrophil

Animal Models for Venous Thromboembolism or affiliated genes

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MGI Mouse Phenotypes related to Venous Thromboembolism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5FGA, F8, MTHFR, SERPINC1, F10, F2
2MP:00053808.4F2, SERPINC1, PROCR, F3, F5, FGA
3MP:00107718.4F2, F3, MTHFR, F5, LTC4S, FGA
4MP:00053857.3F2, F10, APOA4, SERPINC1, SERPINA10, PROC
5MP:00036317.3F2, APOA4, SERPINC1, SERPINA10, PROC, F3
6MP:00053877.0CPB2, SERPINC1, APOA4, F2, PROC, PROCR
7MP:00053976.9F2, APOA4, SERPINC1, PROC, PROCR, F3
8MP:00107685.7SERPINA10, SERPINC1, APOH, APOA4, F10, F2
9MP:00053764.5FGA, F2, F10, APOA4, APOH, SERPINC1

Publications for Venous Thromboembolism

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Articles related to Venous Thromboembolism:

(show top 50)    (show all 1109)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Venous Thromboembolism following Elective Aesthetic Plastic Surgery: A Longitudinal Prospective Study in 1254 Patients. (25374678)
2014
3
Extended Venous Thromboembolism Prophylaxis After Colorectal Cancer Resection: A UK Perspective. (25371122)
2014
4
Role of protein S deficiency in children with venous thromboembolism. An observational international cohort study. (25272994)
2014
5
Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer: 1 Week or 4 Week? (24887974)
2014
6
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
7
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
8
Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement. (23387806)
2013
9
Commentary on "Venous Thromboembolism After Face-Lift Surgery Using Local Anesthesia: Results of a Multicenter Survey" (24149626)
2013
10
Intermittent pneumatic compression is effective in reducing venous thromboembolism risk in hospitalised patients. (24361752)
2013
11
Risk of recurrence of unusual site venous thromboembolism. (23756963)
2013
12
Venous thromboembolism prevention in pediatric trauma-time for national guidelines. (24173133)
2013
13
Risk factors for pregnancy-associated venous thromboembolism: a review. (24334422)
2013
14
Validation of the clinical prediction rule for recurrent venous thromboembolism in cancer patients: the Ottawa score. (23525939)
2013
15
Management of venous thromboembolism--controversies and the future. (23531017)
2013
16
Educational outreach visits to improve nurses' use of mechanical venous thromboembolism prevention in hospitalized medical patients. (24238096)
2013
17
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target. (24038168)
2013
18
Evaluation of pharmacologic prophylaxis for venous thromboembolism in patients with chronic liver disease. (23553808)
2013
19
Comparative study of the prevalence of venous thromboembolism after elective spinal surgery. (23383622)
2013
20
Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study. (24067945)
2013
21
Weight-based enoxaparin dosing for venous thromboembolism prophylaxis in the obese trauma patient. (24070664)
2013
22
Prophylaxis against venous thromboembolism after arthroplasty: establishing value requires more than one perspective. Commentary on an article by John T. Schousboe, MD, PhD, and Gregory A. Brown, MD, PhD: "Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty". (23864185)
2013
23
Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. (23830539)
2013
24
Anticoagulation therapy: Long-term dabigatran therapy reduces the risk of recurrent venous thromboembolism. (23478258)
2013
25
Variations in risk assessment models may contribute to the existing gap between venous thromboembolism prophylaxis guidelines and adherence. (23450705)
2012
26
Dabigatran vs. low molecular weight heparin in preventing venous thromboembolism after elective hip and knee arthroplasty: evaluation of selected clinical parameters. (23306297)
2012
27
Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. (18983482)
2009
28
Should patients with venous thromboembolism be screened for thrombophilia? (18501222)
2008
29
The angiotensin-converting enzyme insertion/deletion polymorphism and serum levels of angiotensin-converting enzyme in venous thromboembolism. Data from a case control study. (17938801)
2007
30
Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement. (17292948)
2007
31
Platelet glycoprotein Ia 807C/T and 873G/A polymorphisms in patients with venous thromboembolism. (17164499)
2007
32
Laboratory assessment of hypercoagulable state. A study in a group of patients with venous thromboembolism born in Chioggia. (17519850)
2007
33
Factor V Leiden as a common genetic risk factor for venous thromboembolism. (16579319)
2006
34
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism. (16266904)
2005
35
Challenges in the prevention of venous thromboembolism in the elderly. (15304033)
2004
36
Risk of venous thromboembolism during pregnancy in homozygous carriers of the factor V Leiden mutation: are there any predictive factors? (14996015)
2004
37
A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. (15297315)
2004
38
Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. (15451770)
2004
39
The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status. (14580166)
2003
40
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. (14531916)
2003
41
Different circumstances of the first venous thromboembolism among younger or older heterozygous carriers of the G20210A polymorphism in the prothrombin gene. (12551828)
2003
42
Clinical study of venous thromboembolism during pregnancy and puerperium. (11372769)
2001
43
Bilateral jugular venous thromboembolism and pulmonary emboli in a patient with severe ovarian hyperstimulation syndrome. (11721733)
2001
44
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. (11071624)
2000
45
Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of factor V Leiden--cost-effectiveness analysis. (11127850)
2000
46
Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. (10449697)
1999
47
Factor V Leiden and the common haemochromatosis mutation HFE C282Y: is there an association in familial venous thromboembolic disease? (10520044)
1999
48
The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. (10531147)
1999
49
Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency. (9391725)
1997
50
Etiology and pathogenesis of spontaneous venous thromboembolism]. (8273075)
1993

Variations for Venous Thromboembolism

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Clinvar genetic disease variations for Venous Thromboembolism:

6
id Gene Name Type Significance SNP ID Assembly Location
1F2NM_000506.3(F2): c.*97G> Asingle nucleotide variantPathogenic, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
2F2NM_000506.3(F2): c.1787G> T (p.Arg596Leu)single nucleotide variantPathogenicrs387907201GRCh37Chr 11, 46760876: 46760876

Expression for genes affiliated with Venous Thromboembolism

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Expression patterns in normal tissues for genes affiliated with Venous Thromboembolism

Search GEO for disease gene expression data for Venous Thromboembolism.

Pathways for genes affiliated with Venous Thromboembolism

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Pathways related to Venous Thromboembolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4FGA, F5, F8
29.4F8, PROC, APOH
3
Show member pathways
9.3F2, F10, PROC, VKORC1
48.9F2, P2RY12, FGA
5
Show member pathways
8.8VKORC1, PROC, CPB2, F10, F2
6
Show member pathways
8.1F2, F10, SERPINC1, PROC, F3, F8
7
Show member pathways
8.1F2, F10, SERPINC1, PROC, F3, F8
8
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.5FGA, F2, F5, F8, F3, PROC
9
Show member pathways
7.2F2, F10, SERPINC1, PROC, F3, P2RY12

Compounds for genes affiliated with Venous Thromboembolism

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Compounds related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1inogatran449.8F2, SERPINC1, F5, F3
2organon449.7F3, F2, F10, SERPINC1
3rivaroxaban44 1110.7F2, F10, SERPINC1, F3
4ecarin449.6F5, SERPINC1, F3, F10, F2
5spectrozyme449.6F10, F2, F3, F5, SERPINC1
6danaparoid449.6F5, F3, F10, SERPINC1, F2
7ximelagatran44 1110.6SERPINC1, F5, F2, F10, F3
8heparinoids449.6F10, SERPINC1, F3, F5, F2
9fondaparinux449.6F2, SERPINC1, F3, F5, F10
10hirugen449.6F5, FGA, SERPINC1, F2
11protamine sulfate449.6F10, F3, F5, SERPINC1, F2
12vitamin k144 2410.5VKORC1, F3, SERPINC1, F2
13acenocoumarol44 50 1111.5VKORC1, F5, F2, F3
14ristocetin449.4F2, F8, SERPINC1, F3, F5
15ancrod449.4FGA, F5, SERPINC1, F10, F2
16phenprocoumon44 50 1111.4SERPINC1, VKORC1, F2, F3
17desmopressin44 61 28 1112.4F2, F3, F8, F5, SERPINC1
18hydroxyethyl starch449.4SERPINC1, F3, F8, F2
19phosphatidylethanolamine44 1110.2F5, APOH, F2, PROCR, F8, HABP2
20cacl2449.1FGA, F5, F8, F3, F10
21kininogen449.1F5, F2, HABP2, F3, APOH, SERPINC1
22bivalirudin44 1110.1FGA, F5, F3, SERPINC1, F10, F2
23argatroban44 1110.1FGA, F5, F3, SERPINC1, F10, F2
24dextran sulfate449.1F3, F5, SERPINC1, APOH, HABP2, F10
25dermatan sulfate449.1SERPINC1, F5, F2, F3, F10
26kaolin449.1F5, F8, F2, F10, APOH, F3
27tranexamic acid44 1110.1F3, F2, SERPINC1, F8
28coumarins449.1F5, VKORC1, F2, F3, F10, APOH
29cardiolipin44 1110.0APOH, F10, F3, F2, F5, F8
30protamine449.0F10, F2, SERPINC1, F3, F5, FGA
31gamma-carboxyglutamic acid449.0F10, PROC, PROCR, F3, VKORC1, F5
32citrate449.0F5, F8, F3, SERPINC1, F10, F2
33aprotinin44 1110.0F3, SERPINC1, F10, F5, FGA, F2
34tirofiban44 1110.0SERPINC1, F10, F2, P2RY12, F3
35abciximab44 119.9P2RY12, SERPINC1, F10, F2, F3
36clopidogrel44 50 24 1111.8F10, F3, F2, SERPINC1, P2RY12
37coumarin44 2 50 2411.7FGA, F5, VKORC1, F3, SERPINC1, F10
38homocysteine44 249.6F5, F8, MTHFR, APOH, F2, F3
39hirudin448.6FGA, F5, F8, F3, PROCR, F10
40ppack448.5F2, FGA, F3, SERPINC1, F10, P2RY12
41ticlopidine44 119.4SERPINC1, F3, FGA, P2RY12, APOH
42endotoxin448.4F5, FGA, F8, PROCR, APOH, F3
43phospholipid447.7SERPINA10, PROC, PROCR, F3, F8, F5
44warfarin44 50 24 1110.3FGA, F5, VKORC1, F8, MTHFR, F3
45aspirin44 50 28 249.8F5, F8, MTHFR, P2RY12, F3, SERPINC1
46serine446.7F3, PROCR, SERPINA10, F8, F5, FGA
47calcium44 50 24 119.3HABP2, F5, F10, APOH, CPB2, FGA
48creatinine446.2F2, FGA, F5, F8, MTHFR, P2RY12
49fibrinogen445.2FGA, F5, F8, MTHFR, P2RY12, F3
50heparin44 28 24 118.2FGA, F5, F8, MTHFR, P2RY12, F3

GO Terms for genes affiliated with Venous Thromboembolism

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Cellular components related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:03123310.0F10, F3
2Golgi lumenGO:0057969.8PROC, F10, F2
3platelet alpha granule lumenGO:0310939.6FGA, F5, F8
4chylomicronGO:0426279.4APOA4, APOH
5high-density lipoprotein particleGO:0343649.4APOH, APOA4
6endoplasmic reticulum lumenGO:0057889.3F2, F10, APOA4, PROC
7blood microparticleGO:0725629.1F2, APOA4, SERPINC1, FGA
8very-low-density lipoprotein particleGO:0343619.1APOH, APOA4
9cell surfaceGO:0099868.4FGA, F3, APOH, APOA4
10extracellular regionGO:0055767.8F2, HABP2, F10, APOA4, SERPINC1, PROC
11plasma membraneGO:0058867.3F2, F10, SERPINC1, PROC, F3, P2RY12
12extracellular spaceGO:0056156.8FGA, F2, HABP2, APOA4, APOH, SERPINC1

Biological processes related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:00759810.0F3, F10
2positive regulation of blood coagulationGO:0301949.8APOH, F2
3negative regulation of blood coagulationGO:0301959.6APOH, PROC
4peptidyl-glutamic acid carboxylationGO:0171879.6F2, F10, PROC, VKORC1
5negative regulation of fibrinolysisGO:0519189.5CPB2, APOH, F2
6platelet degranulationGO:0025769.5F8, F5, FGA
7post-translational protein modificationGO:0436879.5F2, F10, PROC, VKORC1
8blood coagulation, intrinsic pathwayGO:0075979.5F2, F10, APOH, F8
9positive regulation of lipoprotein lipase activityGO:0510069.5APOH, APOA4
10fibrinolysisGO:0427309.4CPB2, F2
11proteolysisGO:0065089.4PROC, CPB2, F10, F2
12cellular protein metabolic processGO:0442679.3VKORC1, PROC, F10, F2
13platelet activationGO:0301688.6F2, P2RY12, F8, F5, FGA
14blood coagulationGO:0075966.5FGA, F2, F10, SERPINC1, SERPINA10, CPB2

Molecular functions related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5SERPINA10, SERPINC1, APOH
2phospholipid bindingGO:0055439.4F3, APOH, F10
3copper ion bindingGO:0055079.4APOA4, F8, F5
4serine-type endopeptidase activityGO:0042529.1F5, F8, PROC, F10, HABP2, F2
5lipid bindingGO:0082898.8APOA4, APOH, LTC4S
6protein bindingGO:0055157.0F2, F10, APOH, SERPINC1, PROC, PROCR

Products for genes affiliated with Venous Thromboembolism

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Sources for Venous Thromboembolism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet