MCID: VNS010
MIFTS: 54

Venous Thromboembolism malady

Blood category

Summaries for Venous Thromboembolism

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A venous thrombosis (or phlebothrombosis) is a blood clot (thrombus) that forms within a vein.... more...

MalaCards: Venous Thromboembolism is related to thromboembolism and thrombophilia. An important gene associated with Venous Thromboembolism is HABP2 (hyaluronan binding protein 2), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The compounds fibrinogen and aspirin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and spinal cord, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Description from OMIM:47 188050

Aliases & Classifications for Venous Thromboembolism

Sources:
47OMIM, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

venous thromboembolism 47 61


Related Diseases for Venous Thromboembolism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venous Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism32.3F8, HABP2, APOH, TNXA, F5, MTHFR
2thrombophilia31.4F5, F8, APOH, TNXA, MTHFR, F10
3venous thrombosis31.1SERPINC1, F8, APOH, TNXA, F5, MTHFR
4hyperhomocysteinemia30.8SERPINC1, THBD, F2, MTHFR, F5, F8
5protein c deficiency30.6MTHFR, F5, APOH, PROCR, SERPINC1, THBD
6thrombocytopenia30.6SERPINC1, THBD, F2, F3, FGA, F7
7colorectal cancer30.6MTHFR
8antiphospholipid syndrome30.5F5, F8, APOH, TNXA, MTHFR, F10
9protein s deficiency30.5APOH, F8, F5, MTHFR, FGA, F3
10atherosclerosis30.4HABP2, VKORC1, MTHFR, PROCR, F7, FGA
11factor v deficiency30.4F2, F3, F5, F8
12arthritis30.4F10
13factor v leiden thrombophilia30.3SERPINC1, TNXA, F8, THBD, F2, F3
14vascular disease30.3APOH, F5, MTHFR, F7, FGA, F3
15thrombocytosis30.3THBD, F2, F3, FGA, F10, SERPINC1
16sickle cell disease30.3FGA
17varicose veins30.3F2
18polycythemia vera30.3THBD
19stroke, ischemic30.3F5, F2
20acute leukemia30.3MTHFR, FGA
21sepsis30.0F5, F10, PROCR, PROC, F7, FGA
22pregnancy loss30.0APOH, SERPINC1, F2, F3, F10, MTHFR
23systemic lupus erythematosus30.0APOH, F8, F10, PROCR, FGA, F3
24portal vein thrombosis30.0SERPINC1, F2, MTHFR, F5, F8
25acute myocardial infarction30.0SERPINC1, THBD, F3, FGA, F7, F10
26coronary artery disease,30.0MTHFR, F10, F7, FGA, F3, THBD
27eclampsia30.0SERPINC1, THBD, MTHFR
28thrombophlebitis30.0F8, APOH
29patent foramen ovale30.0F5
30ovarian hyperstimulation syndrome30.0F5
31homocysteinemia30.0MTHFR, F5
32amyloidosis30.0F10
33insulin resistance30.0F8, F7
34angioedema30.0LTC4S
35n syndrome10.4
36essential thrombocythemia10.3
37heparin-induced thrombocytopenia10.3
38homocysteine plasma level10.3
39klinefelter's syndrome10.3
40cushing's syndrome10.3
41vascular cancer10.3
42protein r deficiency10.3
43breast reconstruction10.2
44klippel-trenaunay syndrome10.2
45hyperprolactinemia10.2
46polycystic ovary syndrome10.2
47morbid obesity10.2
48churg-strauss syndrome10.2
49venous insufficiency10.2
50congenital antithrombin deficiency10.2

Graphical network of the top 20 diseases related to Venous Thromboembolism:



Diseases related to venous thromboembolism

Clinical Features for Venous Thromboembolism

Sources:
47OMIM
See all sources

Clinical features from OMIM:

188050

Drugs & Therapeutics for Venous Thromboembolism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Venous Thromboembolism

Drug clinical trials:

Search ClinicalTrials for Venous Thromboembolism

Search NIH Clinical Center for Venous Thromboembolism

Search CenterWatch for Venous Thromboembolism

Genetic Tests for Venous Thromboembolism

Anatomical Context for Venous Thromboembolism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Venous Thromboembolism:

33
Lymph node, Brain, Spinal cord, Heart, Kidney, Liver, Lung, Breast, Skin, Ovary, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung

Animal Models for Venous Thromboembolism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Venous Thromboembolism

Sources:
51PubMed
See all sources

Articles related to Venous Thromboembolism:

(show top 50)    (show all 1046)
idTitleAuthorsYear
1
Practices to prevent venous thromboembolism: a brief review. (23708438)
2014
2
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
3
Venous thromboembolism prevention in pediatric trauma-time for national guidelines. (24173133)
2013
4
A worldwide survey to assess the current approach to the treatment of patients with cancer and venous thromboembolism. (23945725)
2013
5
Preoperative plasma D-dimer levels predict survival in patients with operable non-small cell lung cancer independently of venous thromboembolism. (23810331)
2013
6
Routine pharmacological venous thromboembolism prophylaxis in frail older hospitalised patients: where is the evidence? (23557678)
2013
7
Treatment of Acute Venous Thromboembolism with Dabigatran or Warfarin and Pooled Analysis. (24344086)
2013
8
An update on venous thromboembolism in cancer. (24225964)
2013
9
Readmission following total knee arthroplasty: venous thromboembolism as a "never event" is a counterproductive misnomer. (23489726)
2013
10
Venous thromboembolism and cancer. (24344060)
2013
11
Antipsychotic drug use and the risk of venous thromboembolism in elderly patients with dementia. (24052055)
2013
12
Awareness of patients who undergo cesarean section about venous thromboembolism prophylaxis. (23481877)
2013
13
Venous thromboembolism in neonates and children--update 2013. (23452739)
2013
14
Predicting short term mortality after investigation for venous thromboembolism. (23415412)
2013
15
The efficacy and safety of rivaroxaban for venous thromboembolism prophylaxis after total hip and total knee arthroplasty. (23533746)
2013
16
Knowledge of thromboprophylaxis guidelines pre- and post-didactic lectures during a venous thromboembolism awareness day at a tertiary-care hospital. (23922612)
2013
17
Prevention of venous thromboembolism in hospitalized patients with inflammatory bowel disease. (23385239)
2013
18
Venous thromboembolism prophylaxis in the nursing home: to do or not to do? (23769428)
2013
19
Hospitalizations of Adults >=60 Years of Age With Venous Thromboembolism. (23814170)
2013
20
Prevention and treatment of venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency. (23662090)
2013
21
Venous thromboembolism in major lower limb orthopedic surgery. (23682171)
2013
22
Risk factors for post-operative venous thromboembolism in patients with a malignancy of the lower limb. (23539711)
2013
23
ASMBS updated position statement on prophylactic measures to reduce the risk of venous thromboembolism in bariatric surgery patients. (23769113)
2013
24
Adjudication-related processes are underreported and lack standardization in clinical trials of venous thromboembolism: a systematic review. (24290147)
2013
25
Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic review. (23760616)
2013
26
Evaluation of recurrent venous thromboembolism in patients with Factor V Leiden mutation in heterozygous form. (22512897)
2012
27
Evaluating proteinuria and nephrotic syndrome in patients with venous thromboembolism. (21760471)
2012
28
Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study. (20352152)
2010
29
Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement. (19407299)
2009
30
New anticoagulants: focus on venous thromboembolism. (19601856)
2009
31
Sex-related type of venous thromboembolism in patients with and without thrombophilia. (19572085)
2009
32
Platelet glycoprotein Ia 807C/T and 873G/A polymorphisms in patients with venous thromboembolism. (17164499)
2007
33
Update on factor V Leiden association with venous thromboembolism in the LITE Study. (17244690)
2007
34
The prevalence of thrombophilia and venous thromboembolism in total knee arthroplasty. (17710975)
2007
35
The Marburg I polymorphism of factor VII-activating protease and the risk of venous thromboembolism. (17479202)
2007
36
Effect of hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C --> T mutation in venous thromboembolism risk of young adults]. (15847749)
2005
37
49, XXXXY syndrome with unilateral renal aplasia, proteinuria, and venous thromboembolism. (15645656)
2004
38
Dyslipidemia, statins, and venous thromboembolism: a potential risk factor and a potential treatment. (12904707)
2003
39
Is recurrent venous thromboembolism more frequent in homozygous patients for the factor V Leiden mutation than in heterozygous patients? (12960604)
2003
40
Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). (12605391)
2003
41
Laboratory thrombophilias and venous thromboembolism. (12402989)
2002
42
Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use. (12069454)
2002
43
Natural history of venous thromboembolism. (15199511)
2001
44
Elevated plasma factor VIII levels--a novel risk factor for venous thromboembolism. (11214218)
2001
45
Hemostatic effects of third- and second-generation oral contraceptives: absence of a causal mechanism for a difference in risk of venous thromboembolism. (11102598)
2000
46
Lengthened activated thromboplastin time in the course of tinzaparin therapy of accidental venous thromboembolism. Pilot study]. (9767923)
1998
47
Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: relationships with plasma homocysteine levels. (9743224)
1998
48
Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation. (9092318)
1997
49
Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. (9107163)
1997
50
Congenital protein C deficiency and venous thromboembolism. A study of three Dutch families. (6688122)
1983

Genetic Variations for Venous Thromboembolism

Expression for genes affiliated with Venous Thromboembolism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venous Thromboembolism

Search GEO for disease gene expression data for Venous Thromboembolism.

Pathways for genes affiliated with Venous Thromboembolism

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8THBD, F8, F5, SERPINC1, F2, F3
2
Hide members
10.8F2, FGA, F7, PROC, F10, F5
3
Hide members
10.8F2, THBD, SERPINC1, F3, FGA, F7
4
Hide members
10.7F5, F10, PROC, F7, F3, F2
5
Hide members
10.7F10, VKORC1, PROZ, PROC, F7, F3
610.6VKORC1, F10, PROZ, PROC, F7, F2
7
Hide members
10.6F8, F5, F7, PROC, F10
8
Hide members
10.6F2, THBD, SERPINC1, FGA, F3
9
Hide members
10.6F7, PROC, VKORC1, F10, PROZ
10
Hide members
10.6FGA, F5, F8
1110.6F2, F7, MTHFR
1210.6F8, APOH, PROC
1310.6PROC, F2, THBD

Compounds for genes affiliated with Venous Thromboembolism

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1fibrinogen4511.3SERPINC1, THBD, F2, FGA, PROC, PROCR
2aspirin45 50 29 2414.3F2, SERPINC1, F10, THBD, F3, FGA
3phospholipid4511.3SERPINA10, THBD, F2, F3, PROC, PROCR
4hirudin4511.2F2, F3, FGA, PROCR, F10, F5
5gamma-carboxyglutamic acid4511.2TNXA, F5, VKORC1, F10, PROCR, PROC
6creatinine4511.2SERPINC1, F2, F3, F7, MTHFR, F5
7bivalirudin45 1112.2F5, F10, FGA, F3, F2, THBD
8argatroban45 1112.2SERPINC1, TNXA, F5, F10, FGA, F3
9kininogen4511.1HABP2, F2, APOH, F5, F7, F3
10fondaparinux4511.1TNXA, F5, F10, F3, F2, THBD
11heparinoids4511.1F5, F10, F3, F2, THBD, SERPINC1
12ximelagatran45 1112.1SERPINC1, F10, F5, F3, F2, THBD
13danaparoid4511.1TNXA, F5, F10, F3, F2, SERPINC1
14coumarin45 2 50 2414.1F3, F10, FGA, SERPINC1, F2, F5
15homocysteine45 2412.1APOH, F8, F5, MTHFR, F3, F2
16ancrod4511.1SERPINC1, THBD, F10, FGA, F2, F5
17heparin45 29 11 2414.1F8, MTHFR, F10, FGA, SERPINA10, APOH
18kaolin4511.1F5, F3, F10, F2, APOH, F8
19protamine4511.1F10, F2, F3, SERPINC1, TNXA, F5
20endotoxin4511.1APOH, F5, THBD, F3, FGA, TNXA
21serine4511.1SERPINA10, F10, FGA, F8, F7, PROCR
22warfarin45 50 11 2414.0SERPINC1, FGA, PROC, VKORC1, APOH
23dermatan sulfate4511.0THBD, TNXA, F5, F10, F3, F2
24cacl24511.0F3, FGA, F5, F8, THBD, F10
25menadione45 11 2413.0F2, F7, PROC, PROZ, VKORC1, F10
26phosphatidylserine45 29 1113.0THBD, F8, F2, F3, F10, F5
27ecarin4511.0SERPINC1, F3, F10, F5, F2
28hirugen4511.0THBD, F5, FGA, F2, SERPINC1
29spectrozyme4511.0F3, F5, F10, F2, SERPINC1
30coumarins4511.0F3, APOH, F10, VKORC1
31aprotinin45 1112.0F10, F3, THBD, FGA, SERPINC1, F5
32desmopressin45 60 29 1114.0F2, SERPINC1, F3, F8, THBD, F5
33Drotrecogin alfa1111.0F5, THBD, F2, PROCR, F8
34phosphatidylethanolamine45 1112.0HABP2, PROCR, F2, F5, F8, APOH
35citrate4510.9THBD, F2, F3, F10, F5, SERPINC1
36ppack4510.9F10, FGA, SERPINC1, F3, F2
37protamine sulfate4510.9F5, F10, F2, F3, SERPINC1
38cardiolipin45 1111.9F10
39inogatran4510.9SERPINC1, F2, F5, F3
40dextran sulfate4510.9F5, APOH, HABP2, F10
41ristocetin4510.9F5, F3, F2, SERPINC1, F8
42levonorgestrel45 60 29 1113.8F2, F7, F5, F3, SERPINC1
43nadroparin45 1111.8F10, F3, SERPINC1, TNXA
44alanine4510.8SERPINC1, MTHFR, SERPINA10, THBD, F2, F3
45prostacyclin4510.7F5, THBD, F3, SERPINC1, FGA, F8
46fibrinopeptide a4510.7SERPINC1, THBD, FGA, F2
47Coagulation Factor IX1110.7F10, F2, F7, F8
48rivaroxaban45 1111.6F10, SERPINC1, F3, F2
49organon4510.5F2, SERPINC1, F3, F10
50tinzaparin45 1111.3SERPINC1, F3, F10, TNXA

GO Terms for genes affiliated with Venous Thromboembolism

Sources:
16Gene Ontology
See all sources

Cellular components related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9SERPINA10, F2, F3, FGA, F7, F5
2extracellular regionGO:00557610.9SERPINC1, ZP1, F2, FGA, F7, PROC
3Golgi lumenGO:00579610.7F10, PROZ, F7, F2, PROC
4endoplasmic reticulum lumenGO:00578810.6F10, PROZ, PROC, F7, F2
5platelet alpha granule lumenGO:03109310.6FGA, F5, F8
6plasma membraneGO:00588610.5F2, SERPINC1, ZP1, F8, F5, F10
7intrinsic to external side of plasma membraneGO:03123310.4F3, F10

Biological processes related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.2SERPINC1, F8, F5, F10, PROCR, PROZ
2peptidyl-glutamic acid carboxylationGO:01718710.9VKORC1, F10, PROZ, PROC, F7, F2
3post-translational protein modificationGO:04368710.9VKORC1, F10, PROZ, PROC, F7, F2
4blood coagulation, intrinsic pathwayGO:00759710.9APOH, F8, F10, F2
5proteolysisGO:00650810.9HABP2, F10, PROZ, PROC, F7, F2
6blood coagulation, extrinsic pathwayGO:00759810.8F10, F7, F3
7cellular protein metabolic processGO:04426710.8VKORC1, F10, PROZ, PROC, F7, F2
8negative regulation of fibrinolysisGO:05191810.8THBD, F2, APOH
9positive regulation of blood coagulationGO:03019410.8APOH, F7, F2
10negative regulation of blood coagulationGO:03019510.8THBD, PROC, APOH
11platelet activationGO:03016810.7F2, FGA, F5, F8
12positive regulation of platelet-derived growth factor receptor signaling pathwayGO:01064110.7F7, F3
13positive regulation of protein kinase B signaling cascadeGO:05189710.6F10, F7, F3
14leukocyte migrationGO:05090010.6THBD, F2, PROC
15positive regulation of positive chemotaxisGO:05092710.5F7, F3
16negative regulation of platelet activationGO:01054410.4F2, THBD
17platelet degranulationGO:00257610.3FGA, F5, F8

Molecular functions related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00550910.6PROZ, PROC, F7, F2, THBD, F10
2serine-type endopeptidase activityGO:00425210.4F2, F7, PROC, PROZ, F10, HABP2

Products for genes affiliated with Venous Thromboembolism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venous Thromboembolism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet