MCID: VNS010
MIFTS: 53

Venous Thromboembolism malady

Blood diseases category
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Summaries for Venous Thromboembolism

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4CDC, 65Wikipedia, 47OMIM, 33MalaCards
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CDC:4 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

MalaCards: Venous Thromboembolism is related to thromboembolism and thrombophilia. An important gene associated with Venous Thromboembolism is HABP2 (hyaluronan binding protein 2), and among its related pathways are Selected targets of HNF1 and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. The compounds ancrod and inogatran have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related mouse phenotypes are embryogenesis and integument.

Wikipedia:65 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

Description from OMIM:47 188050

Aliases & Classifications for Venous Thromboembolism

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47OMIM, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

venous thromboembolism 47 62


Related Diseases for Venous Thromboembolism

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17GeneCards, 18GeneDecks
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Diseases related to Venous Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism32.0F5, F8, MTHFR, F3, PROCR, PROC
2thrombophilia31.0F8, MTHFR, F3, PROCR, PROC, SERPINA10
3hyperhomocysteinemia30.8F2, SERPINC1, MTHFR, F8, F5
4myocardial infarction30.6F10, SERPINC1, PROCR, F3, MTHFR, F8
5pulmonary embolism30.6F5, MTHFR, F3, SERPINC1, F10, F2
6protein s deficiency30.5SERPINC1, F5
7thrombocytopenia30.5F2, F10, SERPINC1, F3, F8, F5
8protein c deficiency30.4F5, MTHFR, PROCR, PROC, SERPINC1, F2
9antithrombin iii deficiency30.4F2, F10, SERPINC1, MTHFR, F5
10venous thrombosis30.3F5, F8, MTHFR, F3, PROCR, PROC
11hypertension30.3F5, MTHFR, F2
12vascular disease30.3F5, MTHFR, F3, SERPINC1
13thrombophlebitis30.2F8
14atherosclerosis30.2HABP2, SERPINC1, PROCR, F3, MTHFR, VKORC1
15antiphospholipid syndrome30.2SERPINC1, F10, F2, PROCR, F3, F5
16homocysteinemia30.2F5, MTHFR
17eclampsia30.2MTHFR, SERPINC1
18acute myocardial infarction30.1F3, SERPINC1, F10
19thrombocytosis30.1F3, SERPINC1, F10, F2
20liver cirrhosis30.1F3, SERPINC1, F10, F2
21factor xi deficiency30.0F2, F3, F8, F5
22lupus erythematosus30.0F2, SERPINC1, PROCR, F3, F5
23coronary artery disease30.0MTHFR, F3, F10
24portal vein thrombosis30.0F5, F8, MTHFR, SERPINC1, F2
25systemic lupus erythematosus30.0F2, F10, PROCR, F3, F8
26sepsis29.9F2, F10, SERPINC1, PROC, PROCR, F3
27pre-eclampsia29.9F2, F10, SERPINC1, F3, MTHFR, F8
28cerebrovascular disease29.7SERPINC1, PROCR, F3, MTHFR, F8, VKORC1
29endotheliitis10.6
30obesity10.5
31inflammatory bowel disease10.4
32lung cancer10.4
33myeloma10.4
34nephrotic syndrome10.4
35essential thrombocythemia10.4
36heparin-induced thrombocytopenia10.4
37cushing's syndrome10.3
38arthritis10.3
39cervical cancer10.3
40cervicitis10.3
41colorectal cancer10.3
42liver disease10.3
43multiple myeloma10.3
44rheumatoid arthritis10.3
45varicose veins10.3
46burns10.2
47breast reconstruction10.2
48klinefelter's syndrome10.2
49polycythemia vera10.2
50klippel-trenaunay syndrome10.2

Graphical network of the top 20 diseases related to Venous Thromboembolism:



Diseases related to venous thromboembolism

Symptoms for Venous Thromboembolism

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47OMIM
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Clinical features from OMIM:

188050

Drugs & Therapeutics for Venous Thromboembolism

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Venous Thromboembolism

Search NIH Clinical Center for Venous Thromboembolism

Genetic Tests for Venous Thromboembolism

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Anatomical Context for Venous Thromboembolism

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33MalaCards
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MalaCards organs/tissues related to Venous Thromboembolism:

33
Lung, Testes, Endothelial, Breast, Heart, Brain, Liver, Kidney, Lymph node, B cells, Ovary, Spinal cord, Bone, Skin

Animal Models for Venous Thromboembolism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Venous Thromboembolism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.7F5, F3, PROCR, SERPINC1, F2
2MP:00107718.0F2, F3, MTHFR, F5, LTC4S
3MP:00053977.9F2, SERPINC1, PROC, PROCR, F3, F8
4MP:00053877.7F2, SERPINC1, PROC, PROCR, F3, F8
5MP:00036317.5F2, SERPINC1, SERPINA10, PROC, F3, MTHFR
6MP:00053857.5F2, F10, SERPINC1, SERPINA10, PROC, F3
7MP:00107686.6SERPINA10, SERPINC1, F10, F2, PROC, PROCR
8MP:00053765.8F5, F2, F10, SERPINC1, SERPINA10, PROC

Publications for Venous Thromboembolism

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52PubMed
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Articles related to Venous Thromboembolism:

(show top 50)    (show all 1074)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Adherence With Postdischarge Venous Thromboembolism Chemoprophylaxis Recommendations After Colorectal Cancer Surgery Among Elderly Medicare Beneficiaries. (24169191)
2013
3
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
4
Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement. (23387806)
2013
5
Commentary on "Venous Thromboembolism After Face-Lift Surgery Using Local Anesthesia: Results of a Multicenter Survey" (24149626)
2013
6
Intermittent pneumatic compression is effective in reducing venous thromboembolism risk in hospitalised patients. (24361752)
2013
7
Risk of recurrence of unusual site venous thromboembolism. (23756963)
2013
8
Venous thromboembolism prevention in pediatric trauma-time for national guidelines. (24173133)
2013
9
Risk factors for pregnancy-associated venous thromboembolism: a review. (24334422)
2013
10
Validation of the clinical prediction rule for recurrent venous thromboembolism in cancer patients: the Ottawa score. (23525939)
2013
11
Management of venous thromboembolism--controversies and the future. (23531017)
2013
12
Educational outreach visits to improve nurses' use of mechanical venous thromboembolism prevention in hospitalized medical patients. (24238096)
2013
13
Fatal venous thromboembolism associated with hospital admission: a cohort study to assess the impact of a national risk assessment target. (24038168)
2013
14
Evaluation of pharmacologic prophylaxis for venous thromboembolism in patients with chronic liver disease. (23553808)
2013
15
Comparative study of the prevalence of venous thromboembolism after elective spinal surgery. (23383622)
2013
16
Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study. (24067945)
2013
17
Weight-based enoxaparin dosing for venous thromboembolism prophylaxis in the obese trauma patient. (24070664)
2013
18
Prophylaxis against venous thromboembolism after arthroplasty: establishing value requires more than one perspective. Commentary on an article by John T. Schousboe, MD, PhD, and Gregory A. Brown, MD, PhD: "Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty". (23864185)
2013
19
Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. (23830539)
2013
20
Anticoagulation therapy: Long-term dabigatran therapy reduces the risk of recurrent venous thromboembolism. (23478258)
2013
21
Association between periodontal disease and venous thromboembolic disease. (23757458)
2013
22
Variations in risk assessment models may contribute to the existing gap between venous thromboembolism prophylaxis guidelines and adherence. (23450705)
2012
23
Dabigatran vs. low molecular weight heparin in preventing venous thromboembolism after elective hip and knee arthroplasty: evaluation of selected clinical parameters. (23306297)
2012
24
The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism. (21743331)
2011
25
Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. (18983482)
2009
26
Should patients with venous thromboembolism be screened for thrombophilia? (18501222)
2008
27
Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement. (17292948)
2007
28
Platelet glycoprotein Ia 807C/T and 873G/A polymorphisms in patients with venous thromboembolism. (17164499)
2007
29
Laboratory assessment of hypercoagulable state. A study in a group of patients with venous thromboembolism born in Chioggia. (17519850)
2007
30
Factor V Leiden as a common genetic risk factor for venous thromboembolism. (16579319)
2006
31
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism. (16266904)
2005
32
Challenges in the prevention of venous thromboembolism in the elderly. (15304033)
2004
33
Risk of venous thromboembolism during pregnancy in homozygous carriers of the factor V Leiden mutation: are there any predictive factors? (14996015)
2004
34
A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. (15297315)
2004
35
Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. (15451770)
2004
36
C-reactive protein gene polymorphisms and the risk of venous thromboembolism: a haplotype-based analysis. (15304023)
2004
37
The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status. (14580166)
2003
38
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. (14531916)
2003
39
Different circumstances of the first venous thromboembolism among younger or older heterozygous carriers of the G20210A polymorphism in the prothrombin gene. (12551828)
2003
40
The risk of recurrent venous thromboembolism among patients with high factor IX levels. (12871536)
2003
41
Clinical study of venous thromboembolism during pregnancy and puerperium. (11372769)
2001
42
Bilateral jugular venous thromboembolism and pulmonary emboli in a patient with severe ovarian hyperstimulation syndrome. (11721733)
2001
43
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. (11071624)
2000
44
Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of factor V Leiden--cost-effectiveness analysis. (11127850)
2000
45
Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. (10449697)
1999
46
Factor V Leiden and the common haemochromatosis mutation HFE C282Y: is there an association in familial venous thromboembolic disease? (10520044)
1999
47
The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. (10531147)
1999
48
Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency. (9391725)
1997
49
Factor V Leiden and risks of recurrent idiopathic venous thromboembolism. (7586244)
1995
50
Etiology and pathogenesis of spontaneous venous thromboembolism]. (8273075)
1993

Variations for Venous Thromboembolism

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Venous Thromboembolism:

1
id Gene Name Type Significance SNP ID Assembly Location
1F2NM_000506.3(F2): c.*97G> Asingle nucleotide variantPathogenic, association, risk factorrs1799963GRCh37Chr 11, 46761055: 46761055
2F2NM_000506.3(F2): c.1787G> T (p.Arg596Leu)single nucleotide variantPathogenic, Uncertain significancers387907201GRCh37Chr 11, 46760876: 46760876

Expression for genes affiliated with Venous Thromboembolism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Venous Thromboembolism

Search GEO for disease gene expression data for Venous Thromboembolism.

Pathways for genes affiliated with Venous Thromboembolism

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50PathCards, 12EMD Millipore, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 53QIAGEN, 54R&D Systems
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Pathways related to Venous Thromboembolism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5F8, PROC
2
Show member pathways
8.5VKORC1, PROC, F10, F2
3
Show member pathways
8.5VKORC1, F2, F10, PROC
4
Show member pathways
7.6F8, F5, F3, PROC, SERPINC1, F10
5
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
7.6F2, F10, SERPINC1, PROC, F3, F8
6
Show member pathways
7.6F8, F3, PROC, SERPINC1, F10, F2
7
Show member pathways
7.6F5, F3, F10, F2, PROC, F8

Compounds for genes affiliated with Venous Thromboembolism

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ancrod459.6F5, SERPINC1, F10, F2
2inogatran459.3F2, SERPINC1, F5, F3
3rivaroxaban45 1110.3F2, F10, SERPINC1, F3
4organon459.3F2, SERPINC1, F3, F10
5dabigatran51 4510.2F10, SERPINC1, F3
6certoparin459.2F2, SERPINC1, F3
7ppack459.2F3, SERPINC1, F10, F2
8phosphatidylethanolamine45 1110.1F5, F2, HABP2, PROCR, F8
9tirofiban45 1110.1SERPINC1, F10, F3, F2
10ecarin459.1F2, F5, F10, SERPINC1, F3
11danaparoid459.0F2, F10, SERPINC1, F3, F5
12spectrozyme459.0F2, F10, SERPINC1, F3, F5
13ximelagatran45 1110.0F10, F5, F3, SERPINC1, F2
14heparinoids459.0F2, F3, SERPINC1, F5, F10
15fondaparinux459.0F2, F10, SERPINC1, F5, F3
16bivalirudin45 1110.0F10, SERPINC1, F3, F5, F2
17argatroban45 1110.0F5, F3, SERPINC1, F2, F10
18protamine sulfate459.0F2, F5, F3, F10, SERPINC1
19hydroxyethyl starch459.0F3, F2, SERPINC1, F8
20dextran sulfate459.0F5, HABP2, F10, SERPINC1, F3
21protamine458.9F3, F10, F2, F5, SERPINC1
22tranexamic acid45 119.9SERPINC1, F8, F3, F2
23dermatan sulfate458.9F5, F3, SERPINC1, F10, F2
24kininogen458.9SERPINC1, F2, F3, HABP2, F5
25cacl2458.9F8, F10, F5, F3
26levonorgestrel45 61 29 1111.8F3, F5, F2, SERPINC1
27kaolin458.8F10, F3, F8, F5, F2
28ristocetin458.8SERPINC1, F5, F8, F2, F3
29desmopressin45 61 29 1111.8F2, F8, F3, F5, SERPINC1
30polyethylene glycol458.8F2, F10, SERPINC1, F8, F5
31cardiolipin45 119.7F8, F5, F2, F10, F3
32vitamin k145 249.7F2, SERPINC1, VKORC1, F3
33acenocoumarol45 51 1110.7F2, VKORC1, F5, F3
34aprotinin45 119.7F5, F10, SERPINC1, F3, F2
35phenprocoumon45 51 1110.7VKORC1, F2, SERPINC1, F3
36abciximab45 119.6F2, F10, SERPINC1, F3
37coumarins458.5F3, F5, VKORC1, F2, F10
38citrate458.4F5, F8, F3, SERPINC1, F10, F2
39menadione45 24 1110.3PROC, MTHFR, VKORC1, F2, F10
40homocysteine45 249.3MTHFR, F5, F3, F8, F2, SERPINC1
41hirudin458.3F2, F10, SERPINC1, PROCR, F3, F8
42coumarin45 3 51 2411.2F3, F2, F10, SERPINC1, VKORC1, F5
43gamma-carboxyglutamic acid457.8VKORC1, F3, PROCR, PROC, F10, F5
44phospholipid457.6SERPINA10, PROC, F3, F8, F10, F2
45aspirin45 51 29 2410.6F3, F8, SERPINC1, F10, F2, LTC4S
46alanine457.4F2, F10, F5, SERPINA10, F3, MTHFR
47fibrinogen457.0F10, SERPINC1, PROC, PROCR, F5, F8
48heparin45 29 24 119.9PROC, F8, SERPINA10, SERPINC1, F10, HABP2
49warfarin45 51 24 119.7F10, SERPINC1, PROC, F3, MTHFR, F8
50serine456.6F10, F3, HABP2, SERPINA10, F2, SERPINC1

GO Terms for genes affiliated with Venous Thromboembolism

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16Gene Ontology
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Cellular components related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.5F10, F3
2Golgi lumenGO:0057969.3PROC, F10, F2
3endoplasmic reticulum lumenGO:0057889.1F2, F10, PROC
4extracellular regionGO:0055768.1F2, HABP2, F10, SERPINC1, PROC, F8
5extracellular spaceGO:0056157.9F5, F2, HABP2, SERPINC1, SERPINA10, F3
6plasma membraneGO:0058867.6F10, SERPINC1, PROC, F3, F8, F5

Biological processes related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of proteolysisGO:0301629.8SERPINA10, SERPINC1
2blood coagulation, extrinsic pathwayGO:0075989.7F3, F10
3acute-phase responseGO:0069539.5F2, F8
4blood coagulation, intrinsic pathwayGO:0075979.5F8, F10, F2
5proteolysisGO:0065089.4F2, F10, PROC
6blood circulationGO:0080159.4F5, MTHFR
7platelet activationGO:0301689.3F5, F8, F2
8peptidyl-glutamic acid carboxylationGO:0171878.8F2, F10, PROC, VKORC1
9post-translational protein modificationGO:0436878.7F2, F10, PROC, VKORC1
10cellular protein metabolic processGO:0442678.6VKORC1, PROC, F10, F2
11blood coagulationGO:0075967.2F5, F2, F10, SERPINC1, SERPINA10, PROC

Molecular functions related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042528.0F5, F2, HABP2, F10, PROC, F8
2protein bindingGO:0055157.0F10, SERPINC1, PROC, PROCR, F3, F8

Products for genes affiliated with Venous Thromboembolism

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  • Antibodies
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Sources for Venous Thromboembolism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet