Venous Thromboembolism malady

Blood diseases category

Summaries for Venous Thromboembolism

About this section
3CDC, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.

MalaCards: Venous Thromboembolism is related to thrombophilia and protein c deficiency. An important gene associated with Venous Thromboembolism is HABP2 (hyaluronan binding protein 2), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The compounds fibrinogen and aspirin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Wikipedia:63 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

Description from OMIM:46 188050

Aliases & Classifications for Venous Thromboembolism

About this section
See all sources


Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases

Aliases & Descriptions:

venous thromboembolism 46 60

Related Diseases for Venous Thromboembolism

About this section
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venous Thromboembolism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia31.4SERPINC1, TNXA, APOH, F8, SERPINA10, THBD
2protein c deficiency30.8APOH, F5, MTHFR, PROCR, PROC, F2
3hyperhomocysteinemia30.8SERPINC1, THBD, F2, MTHFR, F5, F8
4myocardial infarction30.7F3, SERPINC1, FGA, F7, F8, F5
6pulmonary embolism30.6F10, FGA, F3, F2, SERPINC1, MTHFR
7protein s deficiency30.6F8, F5, MTHFR, FGA, F3, F2
8thrombocytopenia30.5SERPINC1, THBD, F2, F3, FGA, F7
9colorectal cancer30.5MTHFR
10antiphospholipid syndrome30.5F5, F8, APOH, TNXA, MTHFR, F10
11antithrombin iii deficiency30.5APOH, F5, MTHFR, F10, SERPINC1, F2
12nephrotic syndrome30.5SERPINC1, FGA
13atherosclerosis30.4SERPINC1, APOH, HABP2, VKORC1, MTHFR, PROCR
14factor v deficiency30.4F2, F3, F8, F5
15rheumatoid arthritis30.4MTHFR, APOH, F10
17ovarian cancer30.4FGA
18factor v leiden thrombophilia30.2F10, VKORC1, F5, F8, TNXA, F7
19vascular disease30.2SERPINC1, APOH, F5, F7, FGA, F3
20thrombocytosis30.2F10, FGA, F3, F2, THBD, SERPINC1
21leukemia30.2MTHFR, F10, F8, LTC4S, FGA
22hypertension30.2F2, F5, MTHFR
23sickle cell disease30.2FGA
24breast cancer30.2PROCR, F10, MTHFR
25polycythemia vera30.2THBD
26proteinuria30.2APOH, FGA
27acute leukemia30.2FGA, MTHFR
28stroke, ischemic30.2F2, F5
29thromboembolism30.0MTHFR, F5, F8, HABP2, APOH, TNXA
30pre-eclampsia30.0APOH, F8, F5, MTHFR, SERPINC1, THBD
31systemic lupus erythematosus30.0F8, THBD, F2, F3, FGA, APOH
32acute myocardial infarction30.0SERPINC1, THBD, F3, FGA, F7, F10
33lupus erythematosus30.0SERPINC1, F2, APOH, F5, PROCR, F3
34portal vein thrombosis30.0F8, F5, MTHFR, F2, SERPINC1
35factor xi deficiency30.0F3, F7, F5, F8, F2
36coronary artery disease30.0THBD, MTHFR, F10, F7, FGA, F3
37eclampsia30.0SERPINC1, THBD, MTHFR
38thrombophlebitis30.0F8, APOH
39cerebrovascular disease30.0MTHFR, APOH
40patent foramen ovale30.0F5
41ovarian hyperstimulation syndrome30.0F5
45liver cirrhosis30.0SERPINC1, F2, F3, F10
47inflammatory bowel disease10.4
48lung cancer10.4
50cushing's syndrome10.3

Graphical network of the top 20 diseases related to Venous Thromboembolism:

Diseases related to venous thromboembolism

Clinical Features for Venous Thromboembolism

About this section
See all sources

Clinical features from OMIM:


Drugs & Therapeutics for Venous Thromboembolism

About this section
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Venous Thromboembolism

Drug clinical trials:

Search ClinicalTrials for Venous Thromboembolism

Search NIH Clinical Center for Venous Thromboembolism

Search CenterWatch for Venous Thromboembolism

Genetic Tests for Venous Thromboembolism

About this section

Anatomical Context for Venous Thromboembolism

About this section
See all sources

MalaCards organs/tissues related to Venous Thromboembolism:


Animal Models for Venous Thromboembolism or affiliated genes

About this section
See all sources

MGI Mouse Phenotypes related to Venous Thromboembolism:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.1FGA, F7, APOH, F8, F5, VKORC1
2MP:001076811.1SERPINC1, APOH, F8, MTHFR, F7, PROZ
3MP:000538710.9ZP1, F2, LTC4S, SERPINC1, THBD, F3
4MP:000538510.9F10, PROZ, LTC4S, FGA, F3, F7
5MP:000539710.8SERPINC1, ZP1, THBD, F2, F3, FGA
6MP:000538910.7MTHFR, F10, FGA, F8, F2, THBD
7MP:000538010.7PROCR, F2, FGA, F3, SERPINC1, THBD
8MP:001077110.5F2, LTC4S, FGA
9MP:000363110.4PROC, F3, F2, THBD, SERPINC1, MTHFR

Publications for Venous Thromboembolism

About this section

Genetic Variations for Venous Thromboembolism

About this section

Expression for genes affiliated with Venous Thromboembolism

About this section
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venous Thromboembolism

Search GEO for disease gene expression data for Venous Thromboembolism.

Pathways for genes affiliated with Venous Thromboembolism

About this section
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 49PharmGKB, 12EMD Millipore
See all sources

Pathways related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Hide members
10.8F8, F5, F10, PROC, F7, FGA
Hide members
10.8SERPINC1, THBD, F2, F3, FGA, F7
Hide members
10.8F8, F5, F10, PROC, F7, FGA
Hide members
10.7SERPINC1, THBD, F2, F3, FGA, F7
Hide members
10.7VKORC1, F2, F3, F7, PROC, PROZ
610.6VKORC1, F10, PROZ, PROC, F7, F2
Hide members
10.6F8, F5, F10, PROC, F7
Hide members
Hide members
10.6VKORC1, F10, PROZ, PROC, F7
Hide members
10.6FGA, F5, F8
1110.6MTHFR, F7, F2
1210.6PROC, F8, APOH
1310.6THBD, F2, PROC

Compounds for genes affiliated with Venous Thromboembolism

About this section
44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1fibrinogen4411.3SERPINC1, THBD, F2, FGA, PROC, PROCR
2aspirin44 49 28 2414.3F2, SERPINC1, F10, THBD, F3, FGA
3phospholipid4411.3SERPINA10, THBD, F2, F3, PROC, PROCR
4hirudin4411.2F2, F3, FGA, PROCR, F10, F5
5gamma-carboxyglutamic acid4411.2TNXA, F5, VKORC1, F10, PROCR, PROC
6creatinine4411.2SERPINC1, F2, F3, F7, MTHFR, F5
7bivalirudin44 1112.2F5, F10, FGA, F3, F2, THBD
8argatroban44 1112.2SERPINC1, TNXA, F5, F10, FGA, F3
9kininogen4411.1HABP2, F2, APOH, F5, F7, F3
10fondaparinux4411.1TNXA, F5, F10, F3, F2, THBD
11heparinoids4411.1F5, F10, F3, F2, THBD, SERPINC1
12ximelagatran44 1112.1SERPINC1, F10, F5, F3, F2, THBD
13danaparoid4411.1TNXA, F5, F10, F3, F2, SERPINC1
14coumarin44 2 49 2414.1F3, F10, FGA, SERPINC1, F2, F5
15homocysteine44 2412.1APOH, F8, F5, MTHFR, F3, F2
16ancrod4411.1SERPINC1, THBD, F10, FGA, F2, F5
17heparin44 28 11 2414.1F8, MTHFR, F10, FGA, SERPINA10, APOH
18kaolin4411.1F5, F3, F10, F2, APOH, F8
19protamine4411.1F10, F2, F3, SERPINC1, TNXA, F5
20endotoxin4411.1APOH, F5, THBD, F3, FGA, TNXA
21serine4411.1SERPINA10, F10, FGA, F8, F7, PROCR
22warfarin44 49 11 2414.0SERPINC1, FGA, PROC, VKORC1, APOH
23dermatan sulfate4411.0THBD, TNXA, F5, F10, F3, F2
24cacl24411.0F3, FGA, F5, F8, THBD, F10
25menadione44 11 2413.0F2, F7, PROC, PROZ, VKORC1, F10
26phosphatidylserine44 28 1113.0THBD, F8, F2, F3, F10, F5
27ecarin4411.0SERPINC1, F3, F10, F5, F2
28hirugen4411.0THBD, F5, FGA, F2, SERPINC1
29spectrozyme4411.0F3, F5, F10, F2, SERPINC1
30coumarins4411.0F3, APOH, F10, VKORC1
31aprotinin44 1112.0F10, F3, THBD, FGA, SERPINC1, F5
32desmopressin44 59 28 1114.0F2, SERPINC1, F3, F8, THBD, F5
33Drotrecogin alfa1111.0F5, THBD, F2, PROCR, F8
34phosphatidylethanolamine44 1112.0HABP2, PROCR, F2, F5, F8, APOH
35citrate4410.9THBD, F2, F3, F10, F5, SERPINC1
36ppack4410.9F10, FGA, SERPINC1, F3, F2
37protamine sulfate4410.9F5, F10, F2, F3, SERPINC1
38cardiolipin44 1111.9F10
39inogatran4410.9SERPINC1, F2, F5, F3
40dextran sulfate4410.9F5, APOH, HABP2, F10
41ristocetin4410.9F5, F3, F2, SERPINC1, F8
42levonorgestrel44 59 28 1113.8F2, F7, F5, F3, SERPINC1
43nadroparin44 1111.8F10, F3, SERPINC1, TNXA
44alanine4410.8SERPINC1, MTHFR, SERPINA10, THBD, F2, F3
45prostacyclin4410.7F5, THBD, F3, SERPINC1, FGA, F8
46fibrinopeptide a4410.7SERPINC1, THBD, FGA, F2
47Coagulation Factor IX1110.7F10, F2, F7, F8
48rivaroxaban44 1111.6F10, SERPINC1, F3, F2
49organon4410.5F2, SERPINC1, F3, F10
50tinzaparin44 1111.3SERPINC1, F3, F10, TNXA

GO Terms for genes affiliated with Venous Thromboembolism

About this section
16Gene Ontology
See all sources

Cellular components related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9SERPINA10, F2, F3, FGA, F7, F5
2extracellular regionGO:00557610.9SERPINC1, ZP1, F2, FGA, F7, PROC
3Golgi lumenGO:00579610.7F10, PROZ, F7, F2, PROC
4endoplasmic reticulum lumenGO:00578810.6F10, PROZ, PROC, F7, F2
5platelet alpha granule lumenGO:03109310.6FGA, F5, F8
6plasma membraneGO:00588610.5F2, SERPINC1, ZP1, F8, F5, F10
7intrinsic to external side of plasma membraneGO:03123310.4F3, F10

Biological processes related to Venous Thromboembolism according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.2PROCR, F2, F3, FGA, F7, PROC
2peptidyl-glutamic acid carboxylationGO:01718710.9F7, PROZ, PROC, F2, F10, VKORC1
3post-translational protein modificationGO:04368710.9F2, PROC, VKORC1, F7, PROZ, F10
4blood coagulation, intrinsic pathwayGO:00759710.9F10, APOH, F2, F8
5proteolysisGO:00650810.9PROZ, F10, HABP2, F2, F7, PROC
6blood coagulation, extrinsic pathwayGO:00759810.8F7, F3, F10
7cellular protein metabolic processGO:04426710.8PROC, F7, PROZ, F10, VKORC1, F2
8negative regulation of fibrinolysisGO:05191810.8APOH, THBD, F2
9positive regulation of blood coagulationGO:03019410.8APOH, F7, F2
10negative regulation of blood coagulationGO:03019510.8PROC, THBD, APOH
11platelet activationGO:03016810.7F2, FGA, F8, F5
12positive regulation of platelet-derived growth factor receptor signaling pathwayGO:01064110.7F7, F3
13positive regulation of protein kinase B signaling cascadeGO:05189710.6F7, F10, F3
14leukocyte migrationGO:05090010.6THBD, PROC, F2
15negative regulation of platelet activationGO:01054410.5F2, THBD
16positive regulation of positive chemotaxisGO:05092710.4F3, F7
17platelet degranulationGO:00257610.3FGA, F8, F5

Molecular functions related to Venous Thromboembolism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00550910.6PROZ, PROC, F7, F2, THBD, F10
2serine-type endopeptidase activityGO:00425210.4F2, F7, PROC, PROZ, F10, HABP2

Products for genes affiliated with Venous Thromboembolism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venous Thromboembolism

About this section
26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet