MCID: VNS009
MIFTS: 55

Venous Thrombosis malady

Blood diseases category

Summaries for Venous Thrombosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

MalaCards: Venous Thrombosis is related to protein s deficiency and pulmonary embolism. An important gene associated with Venous Thrombosis is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Selected targets of C EBPalpha and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. The compounds hirugen and ancrod have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related mouse phenotypes are respiratory system and liver/biliary system.

Aliases & Classifications for Venous Thrombosis

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48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

venous thrombosis 48 46 63


Related Diseases for Venous Thrombosis

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18GeneCards, 19GeneDecks
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Diseases related to Venous Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1protein s deficiency31.3F9, SERPINC1, F5
2pulmonary embolism31.0APOH, SERPINC1, F3, F13A1, F2, MTHFR
3thrombophlebitis31.0APOH
4protein c deficiency30.9F5, F2, THBD, F9, APOH, SERPINC1
5antithrombin iii deficiency30.9APOH, F5, SERPINC1, F2, MTHFR
6post-thrombotic syndrome30.9SERPINC1, F5
7hyperhomocysteinemia30.8F2, THBD, F9, APOH, SERPINC1, MTHFR
8hypertension30.7MTHFR, F2, F5
9inflammatory bowel disease30.7F13A1, F5, PROCR
10thrombophilia30.6MTHFR, F5, F3, PROCR, F2, THBD
11thrombocytopenia30.5APOH, SERPINC1, F9, THBD, F3, F2
12behcet's disease30.5APOH, F5, THBD
13antiphospholipid syndrome30.4F2, THBD, APOH, SERPINC1, PROCR, F3
14patent foramen ovale30.4F5
15myocardial infarction30.4F5, F3, PROCR, SERPINC1, MTHFR, F11
16von willebrand's disease30.4F3, F9, F2
17glanzmann's thrombasthenia30.4F3, F9
18factor xii deficiency30.4F13A1, F3, F5
19thromboembolism30.3F2, THBD, F9, F11, F12, APOH
20liver cirrhosis30.3SERPINC1, F9, F2, F3
21homocystinuria30.3SERPINC1, MTHFR, F5
22coronary artery disease30.3F9, F3, MTHFR, THBD
23systemic lupus erythematosus30.3PROCR, F3, THBD, APOH, F2
24retinal vein occlusion30.3MTHFR, APOH, F5, SERPINC1
25lupus erythematosus30.2F3, F2, APOH, THBD, SERPINC1, F5
26hypersplenism30.2F2
27sagittal sinus thrombosis30.1F5, SERPINC1
28stroke, ischemic30.1MTHFR, F2, F5
29portal vein thrombosis30.0MTHFR, F5, F2, SERPINC1
30vasculitis30.0THBD, APOH, F2
31cerebrovascular disease30.0F13A1, F12, APOH, MTHFR
32peripheral vascular disease30.0MTHFR, THBD, F3
33deficiency anemia30.0F9, F3, F2
34dysfibrinogenemia30.0F2, THBD, F13A1, SERPINC1, F5
35hemophilia b29.9F9, F11, F3, F2
36atherosclerosis29.9THBD, PROCR, SERPINC1, F3, F13A1, MTHFR
37afibrinogenemia29.9F11, F3, F5, F2
38factor vii deficiency29.9F3, F5, SERPINC1, F9, F2
39vascular disease29.9F3, SERPINC1, APOH, THBD
40pregnancy loss29.9MTHFR, SERPINC1, F3, F5, APOH, F2
41factor v leiden thrombophilia29.6F2, THBD, F9, F11, F12, SERPINC1
42cerebritis11.2
43artery disease10.5
44headache10.5
45endotheliitis10.5
46ulcerative colitis10.5
47intracranial hypotension10.5
48myeloproliferative disorder10.5
49venous thromboembolism10.5
50heparin-induced thrombocytopenia10.4

Graphical network of the top 20 diseases related to Venous Thrombosis:



Diseases related to venous thrombosis

Symptoms for Venous Thrombosis

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Drugs & Therapeutics for Venous Thrombosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Venous Thrombosis

Drug clinical trials:

Search ClinicalTrials for Venous Thrombosis

Search NIH Clinical Center for Venous Thrombosis

Search CenterWatch for Venous Thrombosis

Genetic Tests for Venous Thrombosis

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Anatomical Context for Venous Thrombosis

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34MalaCards
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MalaCards organs/tissues related to Venous Thrombosis:

34
Lung, Testes, Endothelial, Liver, Monocytes, Brain, Spinal cord, Kidney, Skin, Ovary, Prostate, Breast, Thyroid, T cells, Colon, Appendix

Animal Models for Venous Thrombosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Venous Thrombosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4PROC, F11, F13A1, THBD, F2
2MP:00053708.3THBD, F9, F11, SERPINC1, PROC, F5
3MP:00053807.4F2, THBD, F9, SERPINC1, PROCR, F3
4MP:00053876.7F2, THBD, F9, F11, SERPINC1, PROC
5MP:00053856.7F2, THBD, F9, F13A1, F11, SERPINC1
6MP:00036316.6F12, F11, THBD, F2, SERPINC1, SERPINA10
7MP:00053976.5F2, THBD, F9, F13A1, F11, SERPINC1
8MP:00053786.5F2, THBD, F11, PROC, PROCR, F3
9MP:00107685.4F11, F13A1, F9, THBD, F2, APOH
10MP:00053765.0F5, F2, THBD, F9, F13A1, F11

Publications for Venous Thrombosis

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53PubMed
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Articles related to Venous Thrombosis:

(show top 50)    (show all 1301)
idTitleAuthorsYear
1
Cerebral venous thrombosis after lumbar puncture and treatment with high-dose corticosteroids. (23318159)
2013
2
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
3
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
4
Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. (23925504)
2013
5
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
6
Massive mesenteric and portal venous thrombosis secondary to hormone replacement therapy. (24215058)
2013
7
Cerebral Venous Thrombosis: Diagnosis and Management. (24357654)
2013
8
Total preservation of patency and valve function after percutaneous pharmacomechanical thrombolysis using the TrellisAr-8 system for an acute, extensive deep venous thrombosis. (22391378)
2012
9
Correlation of the diameter of the left common iliac vein with the risk of lower-extremity deep venous thrombosis. (23101919)
2012
10
Thrombophilic polymorphisms - factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T - in Tunisian patients with cerebral venous thrombosis. (22721898)
2012
11
Clinical analysis and misdiagnosis of cerebral venous thrombosis. (23226750)
2012
12
Case report: central venous catheterization via internal jugular vein with associated formation of perioperative venous thrombosis during surgery in the prone position. (22318554)
2012
13
Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis. (22533697)
2012
14
Lupus anticoagulant: a marker for stroke and venous thrombosis in primary SjAPgren's syndrome. (22692396)
2012
15
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
16
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
17
Factor XII C46T gene polymorphism and the risk of cerebral venous thrombosis. (18180442)
2008
18
VKORC1 gene variation and venous thrombosis: 'another one bites the dust'? (17666014)
2007
19
Deep venous thrombosis in a patient with BehAset's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills. (16189654)
2006
20
von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. (17059421)
2006
21
Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation. (16607075)
2006
22
Factor V Leiden mutation and deep venous thrombosis in a patient with hypereosinophilic syndrome. (16951787)
2006
23
Factor V Leiden mutation in venous thrombosis in southeast Turkey. (16518527)
2006
24
Vascular endothelial growth factor and monocyte chemoattractant protein-1 in BehAset's patients with venous thrombosis. (16273763)
2005
25
HR2 haplotype in Arab population and patients with venous thrombosis in Kuwait. (15978104)
2005
26
Deep venous thrombosis. (15561697)
2004
27
Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. (15512986)
2004
28
Anti-thrombomodulin antibodies and venous thrombosis. (15389121)
2004
29
Concomitant heterozygous factor V Leiden mutation and homozygous prothrombin gene variant (G20210A) in patient with cerebral venous thrombosis. (12761462)
2003
30
Polymorphisms in the TAFI gene and the risk of venous thrombosis. (14651335)
2003
31
Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women. (12730085)
2003
32
Acquired and inherited hypercoagulability among patients with cerebral venous thrombosis]. (12396970)
2002
33
Superior mesenteric venous thrombosis associated with a familial missense mutation (Pro626Leu) in the SHBG-like domain of the protein S molecule. (11843280)
2002
34
Coagulation, fibrinolysis, and recanalization after acute deep venous thrombosis. (11854725)
2002
35
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis. (12428084)
2002
36
Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. (12069029)
2002
37
Prevalence of factor V Leiden and prothrombin 20210 A variant in Bulgarian patients with pulmonary thromboembolism and deep venous thrombosis. (11734663)
2001
38
Identification of polymorphisms in the 5'-untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis. (11410415)
2001
39
Risk for venous thrombosis in autoimmune diseases with antiphospholipid antibodies and factor V Leiden mutation among Hungarian patients. (11093465)
2000
40
The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease. (10070834)
1999
41
The 536C-->T transition in the human tissue factor pathway inhibitor (TFPI) gene is statistically associated with a higher risk for venous thrombosis. (10456444)
1999
42
A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin. (9864932)
1998
43
Three novel missense mutations in unrelated Japanese patients with type I and type II protein S deficiency and venous thrombosis. (9651142)
1998
44
Bilateral internal jugular venous thrombosis complicating severe ovarian hyperstimulation syndrome after prophylactic albumin administration. (9207607)
1997
45
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. (7847309)
1995
46
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
47
Splice site mutation in the human protein C gene associated with venous thrombosis: demonstration of exon skipping by ectopic transcript analysis. (8400292)
1993
48
Baseline fibrinolytic state and the risk of future venous thrombosis. A prospective study of endogenous tissue-type plasminogen activator and plasminogen activator inhibitor. (1572039)
1992
49
Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. (1443986)
1992
50
Randomized controlled trial of tissue plasminogen activator in proximal deep venous thrombosis. (2106783)
1990

Variations for Venous Thrombosis

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Expression for genes affiliated with Venous Thrombosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Venous Thrombosis

Search GEO for disease gene expression data for Venous Thrombosis.

Pathways for genes affiliated with Venous Thrombosis

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Sources:
51PathCards, 13EMD Millipore, 56Reactome, 52PharmGKB, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 31KEGG
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Pathways related to Venous Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SERPINC1, F9
2
Show member pathways
9.6F2, F9, PROC
39.4PROC, APOH, F13A1
4
Show member pathways
9.4PROC, THBD, F2
5
Show member pathways
6.3F9, F13A1, F11, F12, SERPINC1, PROC
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
6.3THBD, F9, F13A1, F11, F12, SERPINC1
7
Show member pathways
6.3F2, F5, THBD, F9, F13A1, F11
8
Show member pathways
6.3F2, F5, THBD, F9, F13A1, F11

Compounds for genes affiliated with Venous Thrombosis

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46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Venous Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1hirugen469.4F2, THBD, SERPINC1, F5
2ancrod469.4SERPINC1, F5, THBD, F2
3benzamidine46 1210.2F5, THBD, SERPINC1, F9
4inogatran469.1F3, F5, SERPINC1, F2
5ecarin469.1F2, F5, F3, SERPINC1
6spectrozyme469.1F3, SERPINC1, F5, F2
7organon469.1SERPINC1, F9, F2, F3
8danaparoid469.1F2, F5, F3, SERPINC1
9acenocoumarol46 52 1211.1F5, F3, F9, F2
10certoparin469.0F3, SERPINC1, F2
11phenprocoumon46 52 1211.0F3, F2, F9, SERPINC1
12polybrene469.0F3, SERPINC1, F2
13protamine sulfate469.0F5, F2, F3, SERPINC1
14tranexamic acid46 1210.0SERPINC1, F3, F2, F9
15phosphatidylethanolamine46 129.9F5, APOH, F9, F2, PROCR
16epsilon aminocaproic acid468.8SERPINC1, F9, F2, F3
17coumarin46 3 52 2511.8F9, F2, SERPINC1, F3, F5
18coumarins468.8F5, F3, APOH, F9, F2
19cacl2468.7THBD, F9, F3, F5
20levonorgestrel46 62 30 1211.6SERPINC1, F3, F5, F2
21ximelagatran46 129.6F2, F5, F3, THBD, SERPINC1
22bivalirudin46 129.6THBD, SERPINC1, F3, F5, F2
23argatroban46 129.6F2, THBD, SERPINC1, F3, F5
24heparin sodium468.5F2, THBD, F3
25cardiolipin46 129.5F2, F5, F3, APOH, THBD
26fondaparinux468.4F9, THBD, F2, SERPINC1, F3, F5
27ristocetin468.4F5, F2, F9, F3, SERPINC1, F11
28kaolin468.4F9, F12, APOH, F3, F2, F5
29dextran sulfate468.3APOH, SERPINC1, F3, F11, F9, F5
30heparinoids468.3F5, F3, SERPINC1, F13A1, THBD, F2
31citrate468.3F3, F5, THBD, F9, SERPINC1, F2
32cyclophosphamide46 52 1210.1APOH, F3, F5, MTHFR, F9, THBD
33phosphatidylserine46 30 1210.1F5, APOH, F9, THBD, F2, F3
34desmopressin46 62 30 1210.9F11, SERPINC1, F3, F5, F9, THBD
35dermatan sulfate467.9F5, F3, SERPINC1, F11, F9, THBD
36aprotinin46 128.8F5, F3, SERPINC1, F11, F9, THBD
37gamma-carboxyglutamic acid467.8F5, F2, THBD, F9, PROC, PROCR
38creatinine467.6F3, F5, MTHFR, SERPINC1, F2, APOH
39alanine467.5F2, THBD, F9, SERPINC1, SERPINA10, F3
40estrogen467.5F5, SERPINC1, F2, MTHFR, APOH, F12
41endotoxin467.4F3, THBD, F5, F11, PROCR, APOH
42warfarin46 52 25 1210.4F5, MTHFR, F3, PROC, APOH, F9
43hirudin467.2F5, F3, PROCR, SERPINC1, F11, F2
44homocysteine46 258.2F2, THBD, F9, F11, APOH, SERPINC1
45aspirin46 52 30 2510.1F5, MTHFR, F3, SERPINC1, APOH, F12
46phospholipid466.7PROCR, F2, THBD, F9, F5, F3
47kininogen466.6THBD, F9, F13A1, F11, F12, APOH
48serine465.9F11, F9, THBD, PROCR, F2, F12
49heparin46 30 25 128.8F2, THBD, F9, F13A1, F11, F12
50fibrinogen465.4F13A1, F11, F12, APOH, SERPINC1, PROC

GO Terms for genes affiliated with Venous Thrombosis

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17Gene Ontology
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Cellular components related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6PROC, F9, F2
2Golgi lumenGO:0057969.5F2, F9, PROC
3blood microparticleGO:0725629.1SERPINC1, F13A1, F2
4extracellular regionGO:0055767.7F2, F9, F13A1, F11, F12, SERPINC1
5extracellular spaceGO:0056156.7F5, F2, THBD, F11, F12, APOH
6plasma membraneGO:0058866.7F2, THBD, F9, F11, F12, SERPINC1

Biological processes related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of proteolysisGO:0301629.9SERPINA10, SERPINC1
2peptidyl-glutamic acid carboxylationGO:0171879.9F2, F9, PROC
3fibrinolysisGO:0427309.8F2, F12
4negative regulation of platelet activationGO:0105449.8THBD, F2
5plasminogen activationGO:0316399.8F11, APOH
6positive regulation of fibrinolysisGO:0519199.7F12, F11
7proteolysisGO:0065089.7PROC, F9, F2
8post-translational protein modificationGO:0436879.6PROC, F9, F2
9blood coagulation, extrinsic pathwayGO:0075989.6F3, F9
10positive regulation of blood coagulationGO:0301949.6APOH, F12, F2
11negative regulation of blood coagulationGO:0301959.6THBD, APOH, PROC
12negative regulation of fibrinolysisGO:0519189.6APOH, THBD, F2
13blood circulationGO:0080159.5F5, MTHFR
14leukocyte migrationGO:0509009.5PROC, THBD, F2
15platelet activationGO:0301689.4F2, F13A1, F5
16blood coagulation, intrinsic pathwayGO:0075978.8F2, F9, F11, F12, APOH
17blood coagulationGO:0075965.8F5, F2, THBD, F9, F13A1, F11

Molecular functions related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type aminopeptidase activityGO:0700099.4F12, F11
2calcium ion bindingGO:0055099.1PROC, F9, THBD, F2
3heparin bindingGO:0082019.0F11, APOH, SERPINC1, SERPINA10
4serine-type endopeptidase activityGO:0042528.4F5, PROC, F12, F11, F9, F2
5protein bindingGO:0055155.7F2, THBD, F11, F12, APOH, SERPINC1

Products for genes affiliated with Venous Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venous Thrombosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet