MCID: VNS009
MIFTS: 56

Venous Thrombosis malady

Blood category

Summaries for Venous Thrombosis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 A venous thrombosis (or phlebothrombosis) is a blood clot (thrombus) that forms within a vein.... more...

MalaCards: Venous Thrombosis is related to thrombophilia and protein c deficiency. An important gene associated with Venous Thrombosis is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Collagen biosynthesis and modifying enzymes and Formation of Fibrin Clot (Clotting Cascade). The compounds fibrinogen and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Venous Thrombosis

Sources:
47OMIM, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

venous thrombosis 47 45 61


Related Diseases for Venous Thrombosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Venous Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia31.2SERPINC1, SERPINE1, SERPINA10, THBD, F2, F3
2protein c deficiency31.2SERPINC1, SERPINE1, THBD, F2, PROC, PROCR
3protein s deficiency31.0SERPINC1, F5, F9
4hyperhomocysteinemia30.9SERPINC1, SERPINE1, THBD, F2, CBS, MTHFR
5factor v deficiency30.8F2, F3, F5, F8
6thromboembolism30.8SERPINC1, SERPINE1, THBD, F2, F3, CBS
7thrombophlebitis30.7F8, APOH
8antiphospholipid syndrome30.7SERPINC1, THBD, F2, F3, PROCR, F10
9thrombocytopenia30.7SERPINC1, THBD, F2, F3, F10, F5
10systemic lupus erythematosus30.4THBD, F2, F3, PROCR, F10, F8
11acute leukemia30.4MTHFR, JAK2
12factor v leiden thrombophilia30.3SERPINC1, SERPINE1, THBD, F2, F3, F12
13coronary artery disease,30.3SERPINE1, THBD, F3, CBS, F10, MTHFR
14prothrombin deficiency30.3SERPINC1, F2, F5, APOH
15coronary thrombosis30.3SERPINC1, SERPINE1, F3
16polycythemia vera30.3THBD, JAK2
17hepatitis c30.3F2, F8, F9
18ovarian hyperstimulation syndrome30.3F5
19atherosclerosis30.2SERPINC1, SERPINE1, THBD, F3, CBS, PROCR
20glanzmann's thrombasthenia30.2F3, F10, F8, TNXA, F9
21homocystinuria30.2SERPINC1, CBS, MTHFR, F5
22hepatitis a30.2F2, F8
23patent foramen ovale30.2F5
24varicose veins30.2F2
25sagittal sinus thrombosis30.2SERPINC1, F5
26arthritis30.2F10
27stroke, ischemic30.2F2, F5
28behcet's disease30.2THBD, F5, APOH
29pregnancy loss30.0SERPINC1, F2, F3, F10, MTHFR, F5
30vascular disease30.0SERPINC1, SERPINE1, THBD, F3, CBS, MTHFR
31factor vii deficiency30.0SERPINC1, F2, F3, F10, F5, F8
32hypercholesterolemia30.0SERPINE1, THBD, CBS, F10, F8, F9
33portal vein thrombosis30.0SERPINC1, F2, MTHFR, F5, F8
34dysfibrinogenemia30.0SERPINC1, THBD, F2, F5
35factor viii deficiency30.0F3, F5, F8, F9
36peripheral vascular disease30.0THBD, F3, CBS, MTHFR
37deficiency anemia30.0F2, F3, JAK2, F9
38vasculitis30.0THBD, F2, APOH
39polycystic ovary syndrome30.0SERPINE1
40colorectal cancer30.0MTHFR
41afibrinogenemia30.0FGB
42angioedema30.0F12
43postphlebitic syndrome30.0SERPINC1, F5
44cystic fibrosis30.0F8, F9
45protein r deficiency10.7
46venous thromboembolism10.6
47n syndrome10.5
48headache10.5
49intracranial hypotension10.5
50ulcerative colitis10.5

Graphical network of the top 20 diseases related to Venous Thrombosis:



Diseases related to venous thrombosis

Clinical Features for Venous Thrombosis

Drugs & Therapeutics for Venous Thrombosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Venous Thrombosis

Drug clinical trials:

Search ClinicalTrials for Venous Thrombosis

Search NIH Clinical Center for Venous Thrombosis

Search CenterWatch for Venous Thrombosis

Genetic Tests for Venous Thrombosis

Anatomical Context for Venous Thrombosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Venous Thrombosis:

33
Bone marrow, Lymph node, Brain, Spinal cord, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Appendix

Animal Models for Venous Thrombosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Venous Thrombosis

Sources:
51PubMed
See all sources

Articles related to Venous Thrombosis:

(show top 50)    (show all 1514)
idTitleAuthorsYear
1
Unusual venous thrombosis in a 35-year-old man. (24167216)
2014
2
High prevalence of cerebral venous sinus thrombosis (CVST) as presentation of cystathionine beta-synthase deficiency in childhood: Molecular and clinical findings of Turkish probands. (24211323)
2014
3
Incidence of late deep venous thrombosis among renal transplant patients. (24034019)
2013
4
A population-based study of venous thrombosis in pregnancy in Scotland 1980-2005. (23684606)
2013
5
Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients. (23798713)
2013
6
Residual thrombosis after a first episode of proximal deep venous thrombosis. (23314382)
2013
7
Bilateral deep venous thrombosis associated with bladder compression of the iliac veins. (23841766)
2013
8
Deep venous thrombosis and pulmonary embolism. Part 2--Prevention of recurrences: warfarin or low-molecular-weight heparin for at least 3 months. (23819181)
2013
9
Discrepant ratios of arterial versus venous thrombosis in hemophilia A as compared with hemophilia B. (23681676)
2013
10
Venous thrombosis - Who should be screened for thrombophilia in 2014? (24423604)
2013
11
Case report: central venous catheterization via internal jugular vein with associated formation of perioperative venous thrombosis during surgery in the prone position. (22318554)
2012
12
Critical review of mouse models of venous thrombosis. (22345593)
2012
13
Venous thrombosis following femoral venous access for electrophysiology studies: an on-going challenge. (22298160)
2012
14
Diagnosis and treatment of cerebral venous thrombosis. (23253278)
2012
15
Communicating hydrocephalus due to cerebral venous sinus thrombosis treated with ventriculoperitoneal shunt. (23349607)
2012
16
Bloodstream infection, venous thrombosis, and peripherally inserted central catheters: reappraising the evidence. (22840660)
2012
17
Atypical cerebral venous thrombosis: magnetic resonance imaging and spectroscopy features. (22431835)
2012
18
Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis. (22516069)
2012
19
JAK2 mutation-negative essential thrombocythemia in a child presenting with cerebral venous thrombosis. (22446615)
2012
20
Non conventional mutations associated with myeloproliferative disorders are absent in splanchnic venous thrombosis cases. (22816981)
2012
21
Evaluation of molecular genetic variation associated with deep venous thrombosis in lower limb fractures in traumatic patients. (23897567)
2012
22
Primary iliac venous leiomyosarcoma: a rare cause of deep vein thrombosis in a young patient. (21738532)
2011
23
Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis. (21497883)
2011
24
A homozygous protein C deficiency (Lys 192 del) who developed venous thrombosis for the first time at adulthood. (19822351)
2010
25
Prothrombin gene G20210A mutation in acute deep venous thrombosis patients with poor response to warfarin therapy. (19920886)
2009
26
Assessing the coagulation factor levels, inherited thrombophilia, and ABO blood group on the risk for venous thrombosis among Brazilians. (19398413)
2009
27
Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. (18248600)
2008
28
Mastoiditis, subdural empyema and cortical venous thrombosis. (18517125)
2008
29
Relation between the antithrombin Cambridge II mutation, the risk of venous thrombosis, and the endogenous thrombin generation. (18761717)
2008
30
Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis. A meta-analysis. (17549286)
2007
31
Ischemic brain damage triggers overt disseminated intravascular coagulation in a young woman with cerebral venous sinus thrombosis. (18064339)
2007
32
Use of an interpositional venous graft posterior to the pancreas for LDLT patients with portal vein thrombosis. (17523318)
2007
33
Deep venous thrombosis in a patient with BehAset's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills. (16189654)
2006
34
A prospective study of anticardiolipin antibodies as a risk factor for venous thrombosis in a general population (the HUNT study). (16409447)
2006
35
Comparison of three activated protein C resistance tests in the risk assessment of venous thrombosis in non-carriers of the factor V Leiden mutation. (16601846)
2006
36
Deep venous thrombosis, protein S deficiency and homozygous Factor XII 46T mutation. (15912386)
2005
37
Activated protein C levels in BehAset's disease and risk of venous thrombosis. (15287949)
2004
38
Concomitant heterozygous factor V Leiden mutation and homozygous prothrombin gene variant (G20210A) in patient with cerebral venous thrombosis. (12761462)
2003
39
Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women. (12730085)
2003
40
Genetic polymorphisms associated with acute pulmonary embolism and deep venous thrombosis. (12570104)
2003
41
Spinal cord infarction and recurrent venous thrombosis in association with estrogens and the 20210A allele of the prothrombin gene]. (11742625)
2001
42
Low incidence of venous thrombosis in homozygous patients with NT 20210 G to a prothrombin polymorphism. (10726011)
1999
43
Free-floating thrombus and embolic risk in patients with angiographically confirmed proximal deep venous thrombosis. A prospective study. (9040297)
1997
44
Factor V Leiden mutation in cerebral venous thrombosis. (8841317)
1996
45
Warfarin and reduced central venous thrombosis in home total parenteral nutrition patients. (7647477)
1995
46
Plasma resistance to activated protein C in venous and arterial thrombosis. (7878648)
1994
47
The prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects. (8180338)
1994
48
Homozygous antithrombin deficiency: report of two new cases (99 Leu to Phe) associated with arterial and venous thrombosis. (7831651)
1994
49
Ischemic venous thrombosis caused by a distinct disturbance of the extrinsic clotting system. (8491874)
1993
50
Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases. (2527005)
1989

Genetic Variations for Venous Thrombosis

Expression for genes affiliated with Venous Thrombosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Venous Thrombosis

Search GEO for disease gene expression data for Venous Thrombosis.

Pathways for genes affiliated with Venous Thrombosis

Sources:
54Reactome, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0F8, F5, F10, F11, F12, PROC
2
Hide members
11.0FGB, F3, F2, THBD, SERPINE1, F12
3
Hide members
11.0F2, F11, SERPINE1, SERPINC1, THBD, F3
4
Hide members
10.9THBD, SERPINC1, F2, F3, F12, F5
5
Hide members
10.8F12, F11, F5, JAK2, F8, PROC
6
Hide members
10.7F9, F10, F3, F2, PROC
710.6F9, F10, PROC, F2
8
Hide members
10.6FGB, F2, THBD, F3
910.6SERPINE1, CBS, F2, MTHFR
10
Hide members
10.6SERPINE1, F5, F8, FGB
1110.6THBD, F2, PROC
1210.6APOH, PROC, F8
1310.6JAK2, F11, F12

Compounds for genes affiliated with Venous Thrombosis

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 2BitterDB
See all sources

Compounds related to Venous Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 191)
idCompoundScoreTop Affiliating Genes
1fibrinogen4511.6PROCR, F11, F12, PROC, CBS, FGB
2phospholipid4511.5F9, TNXA, APOH, F8, JAK2, F5
3hirudin4511.5TNXA, F9, F8, F3, FGB, PROCR
4homocysteine45 2412.4F3, F2, THBD, SERPINE1, SERPINC1, CBS
5aspirin45 50 29 2414.4F5, MTHFR, F10, F12, F3, F2
6endotoxin4511.4F5, F11, PROCR, F3, THBD, SERPINE1
7kininogen4511.4F9, APOH, F5, F11, F12, F3
8gamma-carboxyglutamic acid4511.3THBD, PROCR, F10, F5, TNXA, F9
9desmopressin45 60 29 1114.3F2, THBD, SERPINE1, SERPINC1, F3, F11
10dermatan sulfate4511.3F9, TNXA, F5, F10, F11, F3
11alanine4511.3F5, SERPINA10, THBD, F2, F3, SERPINC1
12creatinine4511.3MTHFR, F9, TNXA, APOH, F8, F5
13serine4511.3F9, F8, JAK2, F10, F11, F12
14aprotinin45 1112.2F9, F5, F10, F11, F3, THBD
15estrogen4511.2F10, SERPINC1, SERPINE1, THBD, F12, F2
16heparin45 29 11 2414.2F9, APOH, F8, MTHFR, F10, F11
17ristocetin4511.2SERPINC1, F2, F3, F11, F5, F8
18argatroban45 1112.2SERPINC1, THBD, F2, F3, F10, F5
19kaolin4511.2F2, F3, F12, F10, F5, F8
20fondaparinux4511.2SERPINC1, THBD, F2, F3, F10, F5
21bivalirudin45 1112.2TNXA, F3, F10, SERPINC1, F5, F2
22heparinoids4511.1SERPINC1, THBD, F2, F3, F10, F5
23dextran sulfate4511.1F9, APOH, JAK2, F5, F10, F11
24ximelagatran45 1112.1SERPINC1, THBD, F2, F3, F10, F5
25danaparoid4511.1TNXA, F5, SERPINC1, F2, F3, F10
26ancrod4511.1F2, F10, F5, THBD, SERPINE1, SERPINC1
27Drotrecogin alfa1111.1THBD, F2, PROCR, F5, SERPINE1, F8
28citrate4511.1F10, THBD, SERPINC1, F5, F8, F9
29protamine4511.1SERPINE1, SERPINC1, F2, F3, F10, F5
30tranexamic acid45 1112.1SERPINC1, SERPINE1, F2, F8, F9, F3
31cyclophosphamide45 50 1113.1APOH, THBD, SERPINE1, MTHFR, F3, F9
32warfarin45 50 11 2414.1F9, APOH, PROC, SERPINC1
33phosphatidylserine45 29 1113.1APOH, F8, F10, F3, F2, TNXA
34cacl24511.0F10, THBD, F3, F5, F9, F8
35ecarin4511.0SERPINC1, F2, F3, F10, F5
36coumarins4511.0F9, APOH, F10, F3
37spectrozyme4511.0F2, F10, F5, SERPINC1, F3
38phosphatidylcholine4511.0THBD, F5, F10, F2, F8, TNXA
39organon4511.0F9, F3, SERPINC1, F10, F2
40coumarin45 2 50 2414.0F10, F3, F2, SERPINC1, F9, F5
4111-dehydrothromboxane b24510.9THBD, SERPINE1, APOH, F2, CBS
42cardiolipin45 1111.9F10
43aspartate4510.9F8, JAK2, F10, F2
44phosphatidylethanolamine45 1111.8F8, F5, PROCR, APOH, F9, F2
45protamine sulfate4510.8F3, F5, F10, F2, SERPINC1
46inogatran4510.7F3, F2, SERPINC1, F5
47benzamidine45 1111.7SERPINC1, F9, F5, F10, THBD
48rfviii4510.6F10, F5, F9, F8
49hirugen4510.6SERPINC1, THBD, F2, F5
50epsilon aminocaproic acid4510.4SERPINC1, SERPINE1, F2, F3, F9

GO Terms for genes affiliated with Venous Thrombosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1SERPINE1, SERPINA10, F2, F3, FGB, F12
2plasma membraneGO:00588611.1F3, FGB, PROC, F12, F11, F10
3extracellular regionGO:00557611.1F9, SERPINE1, F2, FGB, PROC, F12
4endoplasmic reticulum lumenGO:00578810.6F2, F9, F10, PROC
5platelet alpha granule lumenGO:03109310.6FGB, F5, F8, SERPINE1
6Golgi lumenGO:00579610.5PROC, F10, F9, F2
7intrinsic to external side of plasma membraneGO:03123310.3F3, F10

Biological processes related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.5SERPINC1, JAK2, F8, F9, F5, F10
2blood coagulation, intrinsic pathwayGO:00759711.1F2, F12, F11, F10, F8, APOH
3negative regulation of fibrinolysisGO:05191810.9APOH, F2, THBD, SERPINE1
4positive regulation of blood coagulationGO:03019410.9APOH, F12, F2, SERPINE1
5peptidyl-glutamic acid carboxylationGO:01718710.9F9, F10, PROC, F2
6platelet activationGO:03016810.9F8, F5, FGB, F2, SERPINE1
7negative regulation of blood coagulationGO:03019510.9APOH, PROC, THBD, SERPINE1
8proteolysisGO:00650810.9F9, F10, F11, F12, PROC, F2
9platelet degranulationGO:00257610.8F8, F5, FGB, SERPINE1
10blood coagulation, extrinsic pathwayGO:00759810.8F3, F10, F9
11fibrinolysisGO:04273010.8SERPINE1, F2, F12
12post-translational protein modificationGO:04368710.7F9, F10, PROC, F2
13positive regulation of fibrinolysisGO:05191910.7F12, F11
14negative regulation of platelet activationGO:01054410.6THBD, F2
15homocysteine metabolic processGO:05066710.6MTHFR, CBS
16plasminogen activationGO:03163910.5APOH, F11
17negative regulation of endopeptidase activityGO:01095110.3SERPINC1, SERPINE1, SERPINA10

Molecular functions related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3F11, F10, F5, JAK2, F8, APOH
2serine-type endopeptidase activityGO:00425210.9F2, PROC, F12, F11, F10, F9
3heparin bindingGO:00820110.7APOH, F11, SERPINA10, SERPINC1
4serine-type aminopeptidase activityGO:07000910.7F12, F11
5serine-type endopeptidase inhibitor activityGO:00486710.6SERPINC1, SERPINE1, SERPINA10
6modified amino acid bindingGO:07234110.6CBS, MTHFR
7protease bindingGO:00202010.5SERPINC1, SERPINE1, F3
8receptor bindingGO:00510210.3JAK2, FGB, F2, SERPINE1

Products for genes affiliated with Venous Thrombosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Venous Thrombosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet