MCID: VNS009
MIFTS: 43

Venous Thrombosis malady

Blood diseases category

Summaries for Venous Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

MalaCards: Venous Thrombosis is related to thrombophilia and protein c deficiency. An important gene associated with Venous Thrombosis is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds fibrinogen and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Venous Thrombosis

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46OMIM, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

venous thrombosis 46 44 60


Related Diseases for Venous Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Venous Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia31.2SERPINC1, SERPINE1, SERPINA10, THBD, F2, F3
2protein c deficiency31.2SERPINC1, SERPINE1, THBD, F2, PROC, PROCR
3pulmonary embolism31.2SERPINC1, F2, F3, FGB, CBS, F10
4protein s deficiency31.2SERPINC1, F5, F9
5intracranial thrombosis30.9SERPINC1, F3, MTHFR, F5, F8, APOH
6antithrombin iii deficiency30.9SERPINC1, F2, F10, MTHFR, F5, APOH
7hyperhomocysteinemia30.9SERPINC1, SERPINE1, THBD, F2, CBS, MTHFR
8thrombophlebitis30.7F8, APOH
9antiphospholipid syndrome30.7SERPINC1, THBD, F2, F3, PROCR, F10
10myocardial infarction30.7SERPINC1, SERPINE1, F3, FGB, CBS, PROCR
11thrombocytopenia30.7SERPINC1, THBD, F2, F3, F10, F5
12hypertension30.6SERPINE1, F2, MTHFR, F5
13factor v deficiency30.5F2, F3, F5, F8
14hepatitis30.5F2, F10, F8, F9
15leukemia30.5CBS, F11, F10, MTHFR, JAK2, F8
16nephrotic syndrome30.5SERPINC1, F9
17sarcoma30.5JAK2, F8
18lupus erythematosus30.4SERPINC1, THBD, F2, F3, PROCR, F5
19systemic lupus erythematosus30.4THBD, F2, F3, PROCR, F10, F8
20factor xii deficiency30.4F3, F5
21acute leukemia30.4MTHFR, JAK2
22behcet's disease30.4THBD, F5, APOH
23von willebrand's disease30.3F2, F3, F11, F5, F8, F9
24coronary artery disease30.3SERPINE1, THBD, F3, CBS, F10, MTHFR
25glanzmann's thrombasthenia30.3F3, F10, F8, TNXA, F9
26prothrombin deficiency30.3SERPINC1, F2, F5, APOH
27liver cirrhosis30.3SERPINC1, F2, F3, F10, F9
28obesity30.3SERPINE1, CBS, JAK2
29coronary thrombosis30.3SERPINC1, SERPINE1, F3
30polycythemia vera30.3THBD, JAK2
31hepatitis a30.3F2, F8
32polycythemia30.3JAK2
33ovarian hyperstimulation syndrome30.3F5
34stroke, ischemic30.3F2, F5
35atherosclerosis30.2SERPINC1, SERPINE1, THBD, F3, CBS, PROCR
36hemophilia b30.2F2, F3, F11, F10, F8, F9
37retinal vein occlusion30.2SERPINC1, MTHFR, F5, APOH
38homocystinuria30.2SERPINC1, CBS, MTHFR, F5
39patent foramen ovale30.2F5
40sagittal sinus thrombosis30.2SERPINC1, F5
41arthritis30.2F10
42ovarian cancer30.2JAK2
43thromboembolism29.9SERPINC1, SERPINE1, THBD, F2, F3, CBS
44factor v leiden thrombophilia29.9SERPINC1, SERPINE1, THBD, F2, F3, F12
45vascular disease29.9SERPINC1, SERPINE1, THBD, F3, CBS, MTHFR
46factor vii deficiency29.9SERPINC1, F2, F3, F10, F5, F8
47breast cancer29.9SERPINE1, CBS, PROCR, F10, MTHFR, JAK2
48portal vein thrombosis29.9SERPINC1, F2, MTHFR, F5, F8
49cerebrovascular disease29.9CBS, F12, MTHFR, APOH
50dysfibrinogenemia29.9SERPINC1, THBD, F2, F5

Graphical network of the top 20 diseases related to Venous Thrombosis:



Diseases related to venous thrombosis

Clinical Features for Venous Thrombosis

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Drugs & Therapeutics for Venous Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Venous Thrombosis

Drug clinical trials:

Search ClinicalTrials for Venous Thrombosis

Search NIH Clinical Center for Venous Thrombosis

Search CenterWatch for Venous Thrombosis

Genetic Tests for Venous Thrombosis

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Anatomical Context for Venous Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Venous Thrombosis:

32
Lung

Animal Models for Venous Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Venous Thrombosis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.5MTHFR, PROC, PROCR, F12, F11, F10
2MP:001076811.4F11, MTHFR, F5, JAK2, F8, APOH
3MP:000539711.2PROC, CBS, F3, F2, THBD, SERPINE1
4MP:000538711.1PROCR, F9, SERPINE1, THBD, F2, F3
5MP:000537811.0JAK2, F5, MTHFR, PROCR, PROC, CBS
6MP:000538511.0F2, F3, CBS, F11, F10, F9
7MP:000537010.9CBS, PROC, F11, F5, SERPINC1, F9
8MP:000538910.8F8, JAK2, MTHFR, F10, CBS, F2
9MP:000538010.7JAK2, THBD, F2, F3, SERPINC1, F5
10MP:000363110.6MTHFR, F12, PROC, F3, THBD, SERPINA10
11MP:001077110.6F2, CBS

Publications for Venous Thrombosis

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Genetic Variations for Venous Thrombosis

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Expression for genes affiliated with Venous Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Venous Thrombosis

Search GEO for disease gene expression data for Venous Thrombosis.

Pathways for genes affiliated with Venous Thrombosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 49PharmGKB, 12EMD Millipore
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Pathways related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0F10, F11, F12, PROC, FGB, F3
2
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11.0F11, F12, PROC, FGB, F3, F2
3
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11.0F9, F8, F5, F10, F11, F12
4
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10.9F5, F10, F12, PROC, FGB, F3
5
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10.8F9, F8, JAK2, F5, F10, F11
6
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10.7F9, F10, PROC, F3, F2
710.6F2, PROC, F10, F9
8
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10.6FGB, F3, F2, THBD
910.6SERPINE1, F2, CBS, MTHFR
10
Hide members
10.6F8, F5, FGB, SERPINE1
1110.6THBD, F2, PROC
1210.6APOH, F8, PROC
1310.6F12, F11, JAK2

Compounds for genes affiliated with Venous Thrombosis

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to Venous Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 191)
idCompoundScoreTop Affiliating Genes
1fibrinogen4411.6PROCR, F11, F12, PROC, CBS, FGB
2phospholipid4411.5F9, TNXA, APOH, F8, JAK2, F5
3hirudin4411.5TNXA, F9, F8, F3, FGB, PROCR
4homocysteine44 2412.4F3, F2, THBD, SERPINE1, SERPINC1, CBS
5aspirin44 49 28 2414.4F5, MTHFR, F10, F12, F3, F2
6endotoxin4411.4F5, F11, PROCR, F3, THBD, SERPINE1
7kininogen4411.4F9, APOH, F5, F11, F12, F3
8gamma-carboxyglutamic acid4411.3THBD, PROCR, F10, F5, TNXA, F9
9desmopressin44 59 28 1114.3F2, THBD, SERPINE1, SERPINC1, F3, F11
10dermatan sulfate4411.3F9, TNXA, F5, F10, F11, F3
11alanine4411.3F5, SERPINA10, THBD, F2, F3, SERPINC1
12creatinine4411.3MTHFR, F9, TNXA, APOH, F8, F5
13serine4411.3F9, F8, JAK2, F10, F11, F12
14aprotinin44 1112.2F9, F5, F10, F11, F3, THBD
15estrogen4411.2F10, SERPINC1, SERPINE1, THBD, F12, F2
16heparin44 28 11 2414.2F9, APOH, F8, MTHFR, F10, F11
17ristocetin4411.2SERPINC1, F2, F3, F11, F5, F8
18argatroban44 1112.2SERPINC1, THBD, F2, F3, F10, F5
19kaolin4411.2F2, F3, F12, F10, F5, F8
20fondaparinux4411.2SERPINC1, THBD, F2, F3, F10, F5
21bivalirudin44 1112.2TNXA, F3, F10, SERPINC1, F5, F2
22heparinoids4411.1SERPINC1, THBD, F2, F3, F10, F5
23dextran sulfate4411.1F9, APOH, JAK2, F5, F10, F11
24ximelagatran44 1112.1SERPINC1, THBD, F2, F3, F10, F5
25danaparoid4411.1TNXA, F5, SERPINC1, F2, F3, F10
26ancrod4411.1F2, F10, F5, THBD, SERPINE1, SERPINC1
27Drotrecogin alfa1111.1THBD, F2, PROCR, F5, SERPINE1, F8
28citrate4411.1F10, THBD, SERPINC1, F5, F8, F9
29protamine4411.1SERPINE1, SERPINC1, F2, F3, F10, F5
30tranexamic acid44 1112.1SERPINC1, SERPINE1, F2, F8, F9, F3
31cyclophosphamide44 49 1113.1APOH, THBD, SERPINE1, MTHFR, F3, F9
32warfarin44 49 11 2414.1F9, APOH, PROC, SERPINC1
33phosphatidylserine44 28 1113.1APOH, F8, F10, F3, F2, TNXA
34cacl24411.0F10, THBD, F3, F5, F9, F8
35ecarin4411.0SERPINC1, F2, F3, F10, F5
36coumarins4411.0F9, APOH, F10, F3
37spectrozyme4411.0F2, F10, F5, SERPINC1, F3
38phosphatidylcholine4411.0THBD, F5, F10, F2, F8, TNXA
39organon4411.0F9, F3, SERPINC1, F10, F2
40coumarin44 2 49 2414.0F10, F3, F2, SERPINC1, F9, F5
4111-dehydrothromboxane b24410.9THBD, SERPINE1, APOH, F2, CBS
42cardiolipin44 1111.9F10
43aspartate4410.9F8, JAK2, F10, F2
44phosphatidylethanolamine44 1111.8F8, F5, PROCR, APOH, F9, F2
45protamine sulfate4410.8F3, F5, F10, F2, SERPINC1
46inogatran4410.7F3, F2, SERPINC1, F5
47benzamidine44 1111.7SERPINC1, F9, F5, F10, THBD
48rfviii4410.6F10, F5, F9, F8
49hirugen4410.6SERPINC1, THBD, F2, F5
50epsilon aminocaproic acid4410.4SERPINC1, SERPINE1, F2, F3, F9

GO Terms for genes affiliated with Venous Thrombosis

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16Gene Ontology
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Cellular components related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1SERPINE1, SERPINA10, F2, F3, FGB, F12
2plasma membraneGO:00588611.1F3, FGB, PROC, F12, F11, F10
3extracellular regionGO:00557611.1F9, SERPINE1, F2, FGB, PROC, F12
4endoplasmic reticulum lumenGO:00578810.6F2, F9, F10, PROC
5platelet alpha granule lumenGO:03109310.6FGB, F5, F8, SERPINE1
6Golgi lumenGO:00579610.5PROC, F10, F9, F2
7intrinsic to external side of plasma membraneGO:03123310.3F3, F10

Biological processes related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.5SERPINC1, JAK2, F8, F9, F5, F10
2blood coagulation, intrinsic pathwayGO:00759711.1F2, F12, F11, F10, F8, APOH
3negative regulation of fibrinolysisGO:05191810.9APOH, F2, THBD, SERPINE1
4positive regulation of blood coagulationGO:03019410.9APOH, F12, F2, SERPINE1
5peptidyl-glutamic acid carboxylationGO:01718710.9F9, F10, PROC, F2
6platelet activationGO:03016810.9F8, F5, FGB, F2, SERPINE1
7negative regulation of blood coagulationGO:03019510.9APOH, PROC, THBD, SERPINE1
8proteolysisGO:00650810.9F9, F10, F11, F12, PROC, F2
9platelet degranulationGO:00257610.8F8, F5, FGB, SERPINE1
10blood coagulation, extrinsic pathwayGO:00759810.8F3, F10, F9
11fibrinolysisGO:04273010.8SERPINE1, F2, F12
12post-translational protein modificationGO:04368710.7F9, F10, PROC, F2
13positive regulation of fibrinolysisGO:05191910.7F12, F11
14negative regulation of platelet activationGO:01054410.6THBD, F2
15homocysteine metabolic processGO:05066710.6MTHFR, CBS
16plasminogen activationGO:03163910.5APOH, F11
17negative regulation of endopeptidase activityGO:01095110.3SERPINC1, SERPINE1, SERPINA10

Molecular functions related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3F11, F10, F5, JAK2, F8, APOH
2serine-type endopeptidase activityGO:00425210.9F2, PROC, F12, F11, F10, F9
3heparin bindingGO:00820110.7APOH, F11, SERPINA10, SERPINC1
4serine-type aminopeptidase activityGO:07000910.7F12, F11
5serine-type endopeptidase inhibitor activityGO:00486710.6SERPINC1, SERPINE1, SERPINA10
6modified amino acid bindingGO:07234110.6CBS, MTHFR
7protease bindingGO:00202010.5SERPINC1, SERPINE1, F3
8receptor bindingGO:00510210.3JAK2, FGB, F2, SERPINE1

Products for genes affiliated with Venous Thrombosis

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Sources for Venous Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet