MCID: VNS009
MIFTS: 60

Venous Thrombosis malady

Blood diseases category
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Summaries for Venous Thrombosis

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Wikipedia:65 A venous thrombus is a blood clot (thrombus) that forms within a vein. Thrombosis is a term for a blood... more...

MalaCards based summary: Venous Thrombosis is related to thrombophlebitis and post-thrombotic syndrome. An important gene associated with Venous Thrombosis is SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10), and among its related pathways are Selected targets of C EBPalpha and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. The drugs dicumarol and phenprocoumon and the compounds hirugen and ancrod have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related mouse phenotypes are respiratory system and liver/biliary system.

Aliases & Classifications for Venous Thrombosis

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Venous Thrombosis, Aliases & Descriptions:

Name: Venous Thrombosis 46 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Related Diseases for Venous Thrombosis

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Diseases related to Venous Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophlebitis31.6APOH
2post-thrombotic syndrome31.3F5, SERPINC1
3patent foramen ovale31.0F5
4hypertension30.9F2, MTHFR, F5
5antithrombin iii deficiency30.9F2, APOH, SERPINC1, MTHFR, F5
6protein s deficiency30.7F2, APOH, SERPINC1, F3, MTHFR, F5
7behcet's disease30.7THBD, APOH, F5
8hypersplenism30.7F2
9inflammatory bowel disease30.6F5, PROCR, F13A1
10sagittal sinus thrombosis30.6F5, SERPINC1
11homocystinuria30.6SERPINC1, MTHFR, F5
12homocysteinemia30.6MTHFR, F5
13von willebrand's disease30.5F2, F9, F3
14glanzmann's thrombasthenia30.4F3, F9
15retinal vein occlusion30.4APOH, SERPINC1, MTHFR, F5
16factor xii deficiency30.4F13A1, F3, F5
17hyperhomocysteinemia30.4F2, THBD, F9, APOH, SERPINC1, MTHFR
18stroke, ischemic30.3F5, MTHFR, F2
19pulmonary embolism30.3F2, F9, F13A1, APOH, SERPINC1, F3
20liver cirrhosis30.2F2, F9, SERPINC1, F3
21portal vein thrombosis30.2F2, SERPINC1, MTHFR, F5
22vasculitis30.2APOH, THBD, F2
23protein c deficiency30.1F2, THBD, F9, APOH, SERPINC1, PROC
24dysfibrinogenemia30.1F2, THBD, F13A1, SERPINC1, F5
25cerebrovascular disease30.0F13A1, F12, APOH, MTHFR
26peripheral vascular disease29.9THBD, F3, MTHFR
27thrombocytopenia29.9F2, THBD, F9, APOH, SERPINC1, F3
28deficiency anemia29.8F2, F9, F3
29hemophilia b29.8F2, F9, F11, F3
30afibrinogenemia29.8F2, F11, F3, F5
31factor vii deficiency29.7F2, F9, SERPINC1, F3, F5
32systemic lupus erythematosus29.7F2, THBD, APOH, PROCR, F3
33vascular disease29.7THBD, APOH, SERPINC1, F3
34antiphospholipid syndrome29.5F2, THBD, APOH, SERPINC1, PROCR, F3
35pregnancy loss29.5F2, APOH, SERPINC1, F3, MTHFR, F5
36myocardial infarction29.4F9, F13A1, F11, SERPINC1, PROCR, F3
37lupus erythematosus29.4F2, THBD, APOH, SERPINC1, PROCR, F3
38atherosclerosis29.0THBD, F13A1, APOH, SERPINC1, PROCR, F3
39thromboembolism28.6F5, F2, THBD, F9, F11, F12
40thrombophilia28.6F9, F13A1, F11, F12, APOH, SERPINC1
41factor v leiden thrombophilia28.5F5, F3, SERPINC1, F12, F2, THBD
42cerebritis11.2
43purpura10.6SERPINC1
44branch retinal artery occlusion10.5F5
45artery disease10.5
46headache10.5
47retinal artery occlusion10.5APOH
48endotheliitis10.5
49warfarin sensitivity10.5F9
50intracranial hypotension10.5

Graphical network of the top 20 diseases related to Venous Thrombosis:



Diseases related to venous thrombosis

Symptoms for Venous Thrombosis

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Drugs & Therapeutics for Venous Thrombosis

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Drug clinical trials:

Search ClinicalTrials for Venous Thrombosis

Search NIH Clinical Center for Venous Thrombosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Venous Thrombosis

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Anatomical Context for Venous Thrombosis

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MalaCards organs/tissues related to Venous Thrombosis:

32
Lung, Testes, Endothelial, Liver, Monocytes, Brain, Spinal cord, Kidney, Skin, Neutrophil, Colon, Thyroid, Breast, Ovary, Prostate, T cells, Appendix

Animal Models for Venous Thrombosis or affiliated genes

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MGI Mouse Phenotypes related to Venous Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4PROC, F11, F13A1, THBD, F2
2MP:00053708.3THBD, F9, F11, SERPINC1, PROC, F5
3MP:00053807.4F2, THBD, F9, SERPINC1, PROCR, F3
4MP:00053876.7F2, THBD, F9, F11, SERPINC1, PROC
5MP:00053856.7F2, THBD, F9, F13A1, F11, SERPINC1
6MP:00036316.6F12, F11, THBD, F2, SERPINC1, SERPINA10
7MP:00053976.5F2, THBD, F9, F13A1, F11, SERPINC1
8MP:00053786.5F2, THBD, F11, PROC, PROCR, F3
9MP:00107685.4F11, F13A1, F9, THBD, F2, APOH
10MP:00053765.0F5, F2, THBD, F9, F13A1, F11

Publications for Venous Thrombosis

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Articles related to Venous Thrombosis:

(show top 50)    (show all 1313)
idTitleAuthorsYear
1
No association between Annexin A5 genetic variants and deep venous thrombosis. (25382354)
2014
2
Cerebral venous thrombosis after lumbar puncture and treatment with high-dose corticosteroids. (23318159)
2013
3
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
4
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? (23609272)
2013
5
Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. (23925504)
2013
6
Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb. (23761869)
2013
7
Massive mesenteric and portal venous thrombosis secondary to hormone replacement therapy. (24215058)
2013
8
Cerebral Venous Thrombosis: Diagnosis and Management. (24357654)
2013
9
Total preservation of patency and valve function after percutaneous pharmacomechanical thrombolysis using the TrellisAr-8 system for an acute, extensive deep venous thrombosis. (22391378)
2012
10
Correlation of the diameter of the left common iliac vein with the risk of lower-extremity deep venous thrombosis. (23101919)
2012
11
Thrombophilic polymorphisms - factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T - in Tunisian patients with cerebral venous thrombosis. (22721898)
2012
12
Clinical analysis and misdiagnosis of cerebral venous thrombosis. (23226750)
2012
13
Case report: central venous catheterization via internal jugular vein with associated formation of perioperative venous thrombosis during surgery in the prone position. (22318554)
2012
14
Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis. (22533697)
2012
15
Lupus anticoagulant: a marker for stroke and venous thrombosis in primary SjAPgren's syndrome. (22692396)
2012
16
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
17
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
18
Factor XII C46T gene polymorphism and the risk of cerebral venous thrombosis. (18180442)
2008
19
VKORC1 gene variation and venous thrombosis: 'another one bites the dust'? (17666014)
2007
20
Deep venous thrombosis in a patient with BehAset's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills. (16189654)
2006
21
von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. (17059421)
2006
22
Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation. (16607075)
2006
23
Factor V Leiden mutation and deep venous thrombosis in a patient with hypereosinophilic syndrome. (16951787)
2006
24
Factor V Leiden mutation in venous thrombosis in southeast Turkey. (16518527)
2006
25
Vascular endothelial growth factor and monocyte chemoattractant protein-1 in BehAset's patients with venous thrombosis. (16273763)
2005
26
HR2 haplotype in Arab population and patients with venous thrombosis in Kuwait. (15978104)
2005
27
Deep venous thrombosis. (15561697)
2004
28
Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. (15512986)
2004
29
Anti-thrombomodulin antibodies and venous thrombosis. (15389121)
2004
30
Concomitant heterozygous factor V Leiden mutation and homozygous prothrombin gene variant (G20210A) in patient with cerebral venous thrombosis. (12761462)
2003
31
Polymorphisms in the TAFI gene and the risk of venous thrombosis. (14651335)
2003
32
Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women. (12730085)
2003
33
Acquired and inherited hypercoagulability among patients with cerebral venous thrombosis]. (12396970)
2002
34
Superior mesenteric venous thrombosis associated with a familial missense mutation (Pro626Leu) in the SHBG-like domain of the protein S molecule. (11843280)
2002
35
Coagulation, fibrinolysis, and recanalization after acute deep venous thrombosis. (11854725)
2002
36
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis. (12428084)
2002
37
Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. (12069029)
2002
38
Prevalence of factor V Leiden and prothrombin 20210 A variant in Bulgarian patients with pulmonary thromboembolism and deep venous thrombosis. (11734663)
2001
39
Identification of polymorphisms in the 5'-untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis. (11410415)
2001
40
Risk for venous thrombosis in autoimmune diseases with antiphospholipid antibodies and factor V Leiden mutation among Hungarian patients. (11093465)
2000
41
The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease. (10070834)
1999
42
The 536C-->T transition in the human tissue factor pathway inhibitor (TFPI) gene is statistically associated with a higher risk for venous thrombosis. (10456444)
1999
43
A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin. (9864932)
1998
44
Three novel missense mutations in unrelated Japanese patients with type I and type II protein S deficiency and venous thrombosis. (9651142)
1998
45
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. (7847309)
1995
46
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
47
Splice site mutation in the human protein C gene associated with venous thrombosis: demonstration of exon skipping by ectopic transcript analysis. (8400292)
1993
48
Baseline fibrinolytic state and the risk of future venous thrombosis. A prospective study of endogenous tissue-type plasminogen activator and plasminogen activator inhibitor. (1572039)
1992
49
Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. (1443986)
1992
50
Randomized controlled trial of tissue plasminogen activator in proximal deep venous thrombosis. (2106783)
1990

Variations for Venous Thrombosis

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Expression for genes affiliated with Venous Thrombosis

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Expression patterns in normal tissues for genes affiliated with Venous Thrombosis

Search GEO for disease gene expression data for Venous Thrombosis.

Pathways for genes affiliated with Venous Thrombosis

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Pathways related to Venous Thrombosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SERPINC1, F9
2
Show member pathways
9.6F2, F9, PROC
39.4PROC, APOH, F13A1
4
Show member pathways
9.4PROC, THBD, F2
5
Show member pathways
6.3F9, F13A1, F11, F12, SERPINC1, PROC
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
6.3THBD, F9, F13A1, F11, F12, SERPINC1
7
Show member pathways
6.3F2, F5, THBD, F9, F13A1, F11
8
Show member pathways
6.3F2, F5, THBD, F9, F13A1, F11

Compounds for genes affiliated with Venous Thrombosis

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Compounds related to Venous Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1hirugen449.4F2, THBD, SERPINC1, F5
2ancrod449.4SERPINC1, F5, THBD, F2
3benzamidine44 1110.2F5, THBD, SERPINC1, F9
4inogatran449.1F3, F5, SERPINC1, F2
5ecarin449.1F2, F5, F3, SERPINC1
6spectrozyme449.1F3, SERPINC1, F5, F2
7organon449.1SERPINC1, F9, F2, F3
8danaparoid449.1F2, F5, F3, SERPINC1
9acenocoumarol44 50 1111.1F5, F3, F9, F2
10certoparin449.0F3, SERPINC1, F2
11phenprocoumon44 50 1111.0F3, F2, F9, SERPINC1
12polybrene449.0F3, SERPINC1, F2
13protamine sulfate449.0F5, F2, F3, SERPINC1
14tranexamic acid44 1110.0SERPINC1, F3, F2, F9
15phosphatidylethanolamine44 119.9F5, APOH, F9, F2, PROCR
16epsilon aminocaproic acid448.8SERPINC1, F9, F2, F3
17coumarin44 2 50 2411.8F9, F2, SERPINC1, F3, F5
18coumarins448.8F5, F3, APOH, F9, F2
19cacl2448.7THBD, F9, F3, F5
20levonorgestrel44 61 28 1111.6SERPINC1, F3, F5, F2
21ximelagatran44 119.6F2, F5, F3, THBD, SERPINC1
22bivalirudin44 119.6THBD, SERPINC1, F3, F5, F2
23argatroban44 119.6F2, THBD, SERPINC1, F3, F5
24heparin sodium448.5F2, THBD, F3
25cardiolipin44 119.5F2, F5, F3, APOH, THBD
26fondaparinux448.4F9, THBD, F2, SERPINC1, F3, F5
27ristocetin448.4F5, F2, F9, F3, SERPINC1, F11
28kaolin448.4F9, F12, APOH, F3, F2, F5
29dextran sulfate448.3APOH, SERPINC1, F3, F11, F9, F5
30heparinoids448.3F5, F3, SERPINC1, F13A1, THBD, F2
31citrate448.3F3, F5, THBD, F9, SERPINC1, F2
32cyclophosphamide44 50 1110.1APOH, F3, F5, MTHFR, F9, THBD
33phosphatidylserine44 28 1110.1F5, APOH, F9, THBD, F2, F3
34desmopressin44 61 28 1110.9F11, SERPINC1, F3, F5, F9, THBD
35dermatan sulfate447.9F5, F3, SERPINC1, F11, F9, THBD
36aprotinin44 118.8F5, F3, SERPINC1, F11, F9, THBD
37gamma-carboxyglutamic acid447.8F5, F2, THBD, F9, PROC, PROCR
38creatinine447.6F3, F5, MTHFR, SERPINC1, F2, APOH
39alanine447.5F2, THBD, F9, SERPINC1, SERPINA10, F3
40estrogen447.5F5, SERPINC1, F2, MTHFR, APOH, F12
41endotoxin447.4F3, THBD, F5, F11, PROCR, APOH
42warfarin44 50 24 1110.4F5, MTHFR, F3, PROC, APOH, F9
43hirudin447.2F5, F3, PROCR, SERPINC1, F11, F2
44homocysteine44 248.2F2, THBD, F9, F11, APOH, SERPINC1
45aspirin44 50 28 2410.1F5, MTHFR, F3, SERPINC1, APOH, F12
46phospholipid446.7PROCR, F2, THBD, F9, F5, F3
47kininogen446.6THBD, F9, F13A1, F11, F12, APOH
48serine445.9F11, F9, THBD, PROCR, F2, F12
49heparin44 28 24 118.8F2, THBD, F9, F13A1, F11, F12
50fibrinogen445.4F13A1, F11, F12, APOH, SERPINC1, PROC

GO Terms for genes affiliated with Venous Thrombosis

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Cellular components related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6PROC, F9, F2
2Golgi lumenGO:0057969.5F2, F9, PROC
3blood microparticleGO:0725629.1SERPINC1, F13A1, F2
4extracellular regionGO:0055767.7F2, F9, F13A1, F11, F12, SERPINC1
5extracellular spaceGO:0056156.7F5, F2, THBD, F11, F12, APOH
6plasma membraneGO:0058866.7F2, THBD, F9, F11, F12, SERPINC1

Biological processes related to Venous Thrombosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of proteolysisGO:0301629.9SERPINA10, SERPINC1
2peptidyl-glutamic acid carboxylationGO:0171879.9F2, F9, PROC
3fibrinolysisGO:0427309.8F2, F12
4negative regulation of platelet activationGO:0105449.8THBD, F2
5plasminogen activationGO:0316399.8F11, APOH
6positive regulation of fibrinolysisGO:0519199.7F12, F11
7proteolysisGO:0065089.7PROC, F9, F2
8post-translational protein modificationGO:0436879.6PROC, F9, F2
9blood coagulation, extrinsic pathwayGO:0075989.6F3, F9
10positive regulation of blood coagulationGO:0301949.6APOH, F12, F2
11negative regulation of blood coagulationGO:0301959.6THBD, APOH, PROC
12negative regulation of fibrinolysisGO:0519189.6APOH, THBD, F2
13blood circulationGO:0080159.5F5, MTHFR
14leukocyte migrationGO:0509009.5PROC, THBD, F2
15platelet activationGO:0301689.4F2, F13A1, F5
16blood coagulation, intrinsic pathwayGO:0075978.8F2, F9, F11, F12, APOH
17blood coagulationGO:0075965.8F5, F2, THBD, F9, F13A1, F11

Molecular functions related to Venous Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type aminopeptidase activityGO:0700099.4F12, F11
2calcium ion bindingGO:0055099.1PROC, F9, THBD, F2
3heparin bindingGO:0082019.0F11, APOH, SERPINC1, SERPINA10
4serine-type endopeptidase activityGO:0042528.4F5, PROC, F12, F11, F9, F2
5protein bindingGO:0055155.7F2, THBD, F11, F12, APOH, SERPINC1

Products for genes affiliated with Venous Thrombosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Venous Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet