Ventricular Fibrillation malady

Wikipedia: Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the...⁴⁴ more...

MalaCards: Ventricular Fibrillation is related to paroxysmal ventricular fibrillation and brugada syndrome. An important gene associated with Ventricular Fibrillation is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Potassium transporters- inward current and Dilated cardiomyopathy. The drugs sotalol and esmolol and the compounds verapamil and nifedipine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and t cells, and related mouse phenotypes are behavior/neurological and muscle.

ventricular fibrillation 7 32 43

Diseases related to ventricular fibrillation by text searches and GeneDecks gene sharing:

(show top 50)    (show all 155)

id	Related Disease	Score	Top Affiliating Genes
1	paroxysmal ventricular fibrillation	34.2	SCN5A, DPP6
2	brugada syndrome	31.6	KCNJ2, KCNJ5, SCN5A, FKBP1B, NPPB, RYR2
3	long qt syndrome	28.2	KCNE1L, KCNE3, KCNJ2, KCNJ5, SCN1B, SCN5A
4	myocardial infarction	26.2	SELP, SELPLG, SERPINE1, ZFHX3, KCNJ5, KCNJ8
5	hypertrophic cardiomyopathy	26.0	SELP, CHKB, ATP2A2, FKBP1B, CACNB2, GLA
6	acute myocardial infarction	25.7	SELP, SELPLG, SERPINE1, ZFHX3, KCNJ5, KCNJ8
7	hypoxia	23.8	SELP, SERPINE1, KCNJ5, KCNJ8, CHKB, ATP2A2
8	brugada syndrome 2	13.6	SCN5A, GPD1L
9	periodic paralyses	13.5	KCNE3, KCNJ2
10	hyperkalemic periodic paralysis	13.5	KCNE3, KCNJ2, SCN1B
11	ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence	13.4	NPPB, RYR2
12	catecholaminergic polymorphic ventricular tachycardia	13.4	SCN5A, NPPB
13	compartment syndrome	13.4	CHKB, MB
14	left ventricular noncompaction	13.4	SCN5A, FKBP1B, RYR2, MYH7
15	familial atrial fibrillation	13.4	KCNE1L, KCNE3, KCNJ2, SCN5A
16	creatine phosphokinase, elevated serum	13.4	CHKB, MB
17	sick sinus syndrome	13.3	SCN5A, HCN4, NPPB
18	familial restrictive cardiomyopathy	13.3	NPPB, MYH7
19	conduction disease	13.2	SCN1B, SCN5A, SCN3B, CACNB2
20	arrhythmogenic right ventricular dysplasia	13.2	SCN5A, FKBP1B, NPPB, RYR2
21	malignant hyperthermia	13.2	CHKB, MB, RYR2
22	neuroleptic malignant syndrome	13.1	CHKB, MB, NPPB
23	congestive heart failure	13.1	CHKB, NPPB, RYR2, MYH7
24	congenital heart defect	13.0	KCNJ2, NPPB, RYR2
25	mitral valve stenosis	13.0	SELP, FGA, NPPB
26	gas gangrene	13.0	CHKB, MB
27	hypokalemia	13.0	KCNE3, KCNJ5, MB
28	gastrinoma	13.0	ENO2, HRH2, CXADR
29	sudden infant death syndrome	12.9	KCNJ2, KCNJ8, SCN1B, SCN5A, SCN3B, GPD1L
30	congenital heart block	12.9	SCN5A, NPPB
31	familial hypertrophic cardiomyopathy	12.8	FKBP1B, NPPB, MYH7
32	alpha 1-antitrypsin deficiency	12.8	SCN5A, CHKB, MB, ENO2, RYR2, MYH7
33	hypokalemic periodic paralysis	12.8	KCNE1L, KCNE3, KCNJ2, CHKB, CACNA1C
34	peripheral arterial occlusive disease	12.7	SELP, SERPINE1, FGA
35	jervell-lange nielsen syndrome	12.7	SCN5A, CACNA1C
36	intermittent claudication	12.7	SELP, SERPINE1, KCNJ5, FGA
37	autonomic dysfunction	12.7	SERPINE1, GLA, NPPB
38	hypertrophy of breast	12.7	KCNJ5, ATP2A2, GLA, NPPB, RYR2, MYH7
39	thromboembolism	12.7	SELP, SERPINE1, FGA
40	cardiac rupture	12.7	CHKB, MMP9, NPPB
41	arterial occlusive disease	12.6	SELP, SERPINE1, FGA
42	orbit rhabdomyosarcoma	12.5	MB, ENO2
43	sudden cardiac death multi-gene panels	12.5	KCNJ2, SCN5A, FKBP1B, MB, NPPB, RYR2
44	primary pulmonary hypertension	12.5	SELP, SERPINE1, FGA, NPPB
45	paralysis	12.4	KCNE3, KCNJ2, KCNJ5, CHKB, MB, CACNA1C
46	septic shock	12.3	SERPINE1, KCNJ5, FGA, TLR4, NPPB
47	cerebral aneurysms	12.3	SELP, CHKB, MMP9, MB
48	venous thrombosis	12.3	SELP, SELPLG, SERPINE1, FGA, MB
49	oculomotor apraxia cogan type	12.2	SERPINE1, CHKB, MB, ENO2, NPPB
50	febrile seizures	12.2	SCN1B, MMP9, ENO2, TLR4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acebutolol, acebutolol hydrochloride, amiodarone, amiodarone hydrochloride, atenolol, bretylium, bretylium tosylate, edetate disodium, epinephrine, epinephrine bitartrate, epinephrine hydrochloride, epinephrine,racemic hydrochloride, epinephryl borate, esmolol, esmolol hydrochloride, isoproterenol, isoproterenol hydrochloride, isoproterenol sulfate, lidocaine, lidocaine hcl pwdr [va product], lidocaine hydrochloride, lidocaine pwdr [va product], magnesium (as sulfate), magnesium sulfate, metoprolol, metoprolol succinate, metoprolol tartrate, mexiletine, mexiletine hydrochloride, moricizine, moricizine hydrochloride, propranolol, propranolol hydrochloride, sotalol, sotalol hydrochloride, vasopressin, vasopressin tannate (in oil)

MalaCards organs/tissues related to ventricular fibrillation:

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MGI Mouse Phenotypes related to ventricular fibrillation:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	INF	, RYR2, CXADR, TLR4, HRH2, GLA
2	muscle phenotype	MP:0005369	INF	ATP2A2, CHKB, SCN5A, KCNJ2, , MMP9
3	renal/urinary system phenotype	MP:0005367	7.3	SELP, SELPLG, SERPINE1, ATP2A2, MMP9, GLA
4	respiratory system phenotype	MP:0005388	INF	KCNJ2, CXADR, TLR4, MB, MMP9, ATP2A2
5	homeostasis/metabolism phenotype	MP:0005376	INF	, HRH2, TLR4, CXADR, SLC22A2, RYR2
6	cardiovascular system phenotype	MP:0005385	INF	SELP, MB, , , TLR4, CXADR
7	nervous system phenotype	MP:0003631	INF	TLR4, HRH2, , FGA, CHKB, SCN5A
8	mortality/aging	MP:0010768	INF	MB, , , TLR4, CXADR, RYR2

Articles related to ventricular fibrillation:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	KCNJ2 variant of unknown significance reclassified as long QT syndrome causing ventricular fibrillation. (21875779)	Obeyesekere M.N.... Krahn A.D.	2011	KCNJ2
2	KCNE5 (KCNE1L) variants are novel modulators of Bruga da syndrome and idiopathic ventricular fibrillation. (21493962)	Ohno S.... Horie M.	2011	KCNE1L
3	Electrocardiographic characteristics and SCN5A mutati ons in idiopathic ventricular fibrillation associated with early repolarization . (22028457)	Watanabe H.... Makita N.	2011	SCN5A
4	The P-selectin gene polymorphism Val168Met: a novel r isk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction. (20586826)	Elmas E.... KAolsch T.	2010	SELP, SCN5A, SELPLG
5	Genome-wide association study identifies a susceptibi lity locus at 21q21 for ventricular fibrillation in acute myocardial infarction . (20622880)	Bezzina C.R.... Wilde A.A.	2010	CXADR
6	Ventricular fibrillation following autologous intramy ocardial cell therapy for inherited cardiomyopathy. (19026577)	Pytel P.... McNally E.M.	2010	MYH7
7	SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome. (21048329)	Nishii N.... Ito H.	2010	SCN5A
8	Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. (18954930)	Oksanen T.... PettilAo V.	2009	ENO2
9	Ventricular fibrillation in MYH7-related hypertrophic cardiomyopathy before onset of ventricular hypertrophy. (19539541)	Christiaans I.... Wilde A.A.	2009	MYH7
10	Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. (19285295)	Alders M.... Wilde A.A.	2009	DPP6
11	Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up. (19075524)	Kawamura M.... Horie M.	2009	SCN5A
12	Plasminogen activator inhibitor-1 (PAI-1), toll-like receptor 4 (TLR4), factor II (FII), FXIII and fibrinogen polymorphisms are not associated with the prevalence of sudden death due to ventricular fibrillation during myocardial infarction. (18785870)	Elmas E.... Borggrefe M.	2008	SERPINE1, TLR4
13	High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction. (17727318)	Elmas E.... Brueckmann M.	2007	MMP9
14	Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017. (17506935)	Na T.... Dai Y.	2007	ATP2A2, FKBP1B
15	Loss of luminal Ca(2+) activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death. (17984046)	Jiang D.... Chen S.R.W.	2007	RYR2
16	Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. (17556186)	Ohgo T.... Shimizu W.	2007	SCN5A
17	Effect of Induced Ventricular Fibrillation and Shock Delivery on Brain Natriuretic Peptide Measured Serially Following a Predischarge ICD Test. (17957267)	Budeus M.... Erbel R.	2007	NPPB, MB
18	Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation. (16649726)	Elmas E.... Borggrefe M.	2006	FGA
19	A novel SCN5A mutation, F1344S, identified in a patient with Brugada syndrome and fever-induced ventricular fibrillation. (16616735)	Keller D.I.... Chahine M.	2006	SCN5A
20	The protective effect of H2-receptor activation against the duration of myocardial hypoxia/reoxygenation-induced ventricular fibrillation in sensitized guinea-pig hearts. (16340155)	Imajo N.... Akagi M.	2005	HRH2
21	Ventricular fibrillation without overt cardiomyopathy as first presentation of organic cation transporter 2-deficiency in adolescenc e. (15125729)	Rijlaarsdam R.S.... Beaufort-Krol G.C.	2004	SLC22A2
22	Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation. (11123251)	Wan X.... Kirsch G.E.	2001	SCN5A
23	Ventricular fibrillation refractory to automatic internal cardiac defibrillator in Fabry's disease. Review of cardiovascular manifestations. (11279328)	Eckart R.E.... Le T.D.	2000	GLA
24	A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. (10940383)	Akai J.... Hiraoka M.	2000	SCN5A
25	HMR 1883, a cardioselective K(ATP) channel blocker, inhibits ischaemia- and reperfusion-induced ventricular fibrillation in rats. (10543431)	Wirth K.J.... Linz W.	1999	KCNJ5
26	Relation between cellular repolarization characterist ics and critical mass for human ventricular fibrillation. (10466488)	Wu T.J.... Chen P.S.	1999	KCNJ5
27	Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. (9521325)	Chen Q.... Wang Q.	1998	SCN5A
28	Usefulness of CKMB and troponin T determinations in patients with acute myocardial infarction complicated by ventricular fibrillation. (8416755)	Zabel M.... Hohnloser S.H.	1993	CHKB

Genes related to ventricular fibrillation according to GeneCards:

(show all 24)

id	Symbol	Description	Score	GeneCards Section Context
1	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.0	Publications
2	DPP6	dipeptidyl-peptidase 6	11.0	Publications
3	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
4	CHKB	choline kinase beta	11.0	Publications
5	RYR2	ryanodine receptor 2 (cardiac)	11.0	Publications
6	KCNE1L	KCNE1-like	11.0	Publications
7	FKBP1B	FK506 binding protein 1B, 12.6 kDa	11.0	Publications
8	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	11.0	Publications
9	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.0	Publications
10	GLA	galactosidase, alpha	11.0	Publications
11	SELPLG	selectin P ligand	11.0	Publications
12	SLC22A2	solute carrier family 22 (organic cation transporter), member 2	11.0	Publications
13	FGA	fibrinogen alpha chain	11.0	Publications
14	HRH2	histamine receptor H2	11.0	Publications
15	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	11.0	Publications
16	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
17	CXADR	coxsackie virus and adenovirus receptor	11.0	Publications
18	TLR4	toll-like receptor 4	11.0	Publications
19	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
20	NPPB	natriuretic peptide B	11.0	Publications
21	MB	myoglobin	11.0	Publications
22	ZFHX3	zinc finger homeobox 3	11.0	Publications
23	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
24	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications

Pathways related to ventricular fibrillation according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	Potassium transporters- inward current10	INF	, , KCNJ5, KCNJ2
2	Dilated cardiomyopathy20	INF	MYH7, , , ATP2A2, RYR2
3	Dopamine-DARPP32 Feedback onto cAMP Pathway36	INF	KCNJ2, , KCNJ5, , , ATP2A2
4	Hypertrophic cardiomyopathy (HCM)20	INF	MYH7, , RYR2, , ATP2A2
5	Cardiac muscle contraction20	INF	RYR2, ATP2A2, , MYH7,
6	GHRH Signaling36	INF	, SCN5A, , ,
7	Celecoxib Pathway, Pharmacodynamics34	INF	ATP2A2, MMP9, ,
8	PKA Signaling36	INF	, SCN5A, , , RYR2,
9	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	INF	ATP2A2, RYR2, ,
10	Synaptic transmission- ion currents10	INF	KCNJ5, ,
11	Activation of cAMP-Dependent PKA36	INF	, SCN5A, , , RYR2,
12	nNOS Signaling in Skeletal Muscle36	INF	RYR2, ,
13	Netrin Signaling36	INF	RYR2, ,
14	cAMP Pathway36	INF	, , , SCN5A, , RYR2
15	Antiarrhythmic Pathway, Pharmacodynamics34	INF	, , RYR2, , FKBP1B, ATP2A2

Compounds related to ventricular fibrillation according to GeneDecks:

(show top 50)    (show all 102)

id	Compound	Score	Top Affiliating Genes
1	verapamil32 34 9 18 9	INF	SCN5A, , SLC22A2, , RYR2
2	nifedipine32 9 9	INF	KCNJ5, MMP9, SERPINE1, SLC22A2, ,
3	potassium32 9 18 9	INF	SCN5A, , KCNJ2, KCNJ5, ,
4	tetrodotoxin citrate42	INF	SCN5A, ,
5	ralfinamide mesylate42	INF	, , SCN5A
6	amlodipine32 9 18 9	INF	, NPPB, SERPINE1,
7	qx 314 chloride42	INF	, SCN5A,
8	flecainide acetate42	INF	SCN5A, ,
9	disopyramide32 9 9	12.1	SLC22A2, SCN5A, KCNJ5
10	isoproterenol32 9 9	11.8	FKBP1B, MYH7, RYR2, HRH2, KCNJ2
11	dantrolene32 9 9	11.7	RYR2, MB, CHKB
12	sodium nitroprusside32	9.6	NPPB, MB, KCNJ5
13	ptca32	9.5	NPPB, FGA, CHKB, SELP
14	ryanodine32	9.5	ATP2A2, FKBP1B, RYR2, MYH7, NPPB
15	batroxobin32	9.3	SERPINE1, FGA, SELP
16	pge232	9.3	SLC22A2, MB, TLR4, NPPB
17	guanidine32 9 18 9	12.2	HRH2, SLC22A2, CHKB, SERPINE1
18	11-dehydrothromboxane b232	9.0	FGA, SELP, SERPINE1
19	fosinopril32 9 9	10.9	SERPINE1, MMP9, NPPB
20	uric acid32 18	9.8	ENO2, NPPB, CHKB, SERPINE1, SLC22A2
21	cocaine32 9 9	10.7	SLC22A2, MB, CHKB, SCN5A, SELP
22	dipyridamole42 32 9 9	11.5	NPPB, SELP, FGA, SERPINE1
23	histamine32 18	9.4	SELP, NPPB, FGA, SELPLG, HRH2, TLR4
24	fluvastatin32 34 9 9	11.4	SELP, SERPINE1, MMP9, MB, CHKB
25	mannitol32 9 9	10.4	SELP, CHKB, MB, ENO2, SERPINE1, GLA
26	tacrolimus32 34 9 9	11.4	NPPB, TLR4, ATP2A2, CHKB, SERPINE1, FKBP1B
27	acetylcholine32 9 18 9	11.2	TLR4, NPPB, HRH2, ENO2, MB, FGA
28	hydrogen32 18	9.2	SELPLG, CHKB, NPPB, GLA, FGA, HRH2
29	atorvastatin32 34 9 18 9	12.1	NPPB, TLR4, MMP9, SERPINE1, CHKB, SELP
30	aspirin32 34 18	10.1	SELP, SERPINE1, CHKB, FGA, HRH2, NPPB
31	fibrinogen32	8.0	TLR4, SERPINE1, CHKB, MMP9, FGA, SELPLG
32	glutamate32	8.0	MB, CXADR, KCNJ5, CHKB, MMP9, RYR2
33	aprotinin32 9 9	9.9	MB, FGA, MMP9, SELP, NPPB, SERPINE1
34	arginine32	7.9	MB, SCN5A, SLC22A2, MYH7, NPPB, CXADR
35	epinephrine32 9 18 9	10.8	RYR2, FGA, CHKB, HRH2, NPPB, SELP
36	norepinephrine32 9 18 9	10.5	NPPB, SLC22A2, ATP2A2, KCNJ5, ENO2, MB
37	heparin32 9 18 9	10.3	SELPLG, SERPINE1, FGA, MB, ENO2, CXADR
38	adenylate32	7.3	MMP9, MB, ENO2, HRH2, CXADR, CHKB
39	cysteine32	7.2	SELP, MMP9, MB, TLR4, CXADR, SLC22A2
40	dexamethasone32 42 34 9 9	11.1	CHKB, SELPLG, MMP9, ENO2, CXADR, SERPINE1
41	aspartate32	7.0	SELP, SERPINE1, SCN5A, CXADR, TLR4, GLA
42	lactate32	6.9	GLA, MB, SELP, KCNJ5, MMP9, FGA
43	nitric oxide32 9 18 9	9.8	RYR2, TLR4, HRH2, CXADR, GLA, ENO2
44	lipid32	6.8	HRH2, KCNJ5, FKBP1B, FGA, ENO2, SERPINE1
45	creatinine32	6.4	MMP9, SERPINE1, SELP, CHKB, FGA, MYH7
46	serine32	6.0	DPP6, SELPLG, ATP2A2, SCN5A, SERPINE1, NPPB
47	calcium32 9 18 9	INF	FGA, FKBP1B, CHKB, SCN5A, , KCNJ2
48	atp32	INF	TLR4, ENO2, FGA, KCNJ5, , CHKB
49	sodium32 18	INF	, SCN5A, ENO2, , , TLR4
50	levosimendan32 9 9	INF	KCNJ5, , NPPB

Cellular components related to ventricular fibrillation according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	RYR2, CXADR, TLR4, , HRH2, ENO2
2	voltage-gated sodium channel complex	GO:001518	INF	, , SCN5A
3	Z disc	GO:030018	INF	MYH7, , RYR2,
4	T-tubule	GO:030315	INF	SCN5A, KCNJ5,
5	integral to plasma membrane	GO:005887	INF	TLR4, SLC22A2, HRH2, , ATP2A2, KCNJ2

Biological processes related to ventricular fibrillation according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium ion transmembrane transport	GO:035725	INF	SCN5A, ,
2	regulation of cardiac muscle cell action potential involved in contraction	GO:086002	INF	, SCN5A,
3	regulation of heart rate by cardiac conduction	GO:086091	INF	, SCN5A,
4	membrane depolarization involved in regulation of cardiac muscle cell action potential	GO:086012	INF	, SCN5A,
5	membrane depolarization	GO:051899	INF	SCN5A, ,
6	cardiac muscle contraction	GO:060048	INF	RYR2, , , SCN5A
7	synaptic transmission	GO:007268	INF	, SLC22A2, , , , KCNJ5
8	regulation of atrial cardiomyocyte membrane depolarization	GO:060371	INF	, SCN5A,
9	regulation of sodium ion transmembrane transporter activity	GO:2000649	INF	,
10	sarcoplasmic reticulum calcium ion transport	GO:070296	10.3	RYR2, ATP2A2
11	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:014808	10.2	FKBP1B, RYR2
12	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	GO:010881	10.1	RYR2, FKBP1B
13	response to redox state	GO:051775	10.1	RYR2, FKBP1B
14	positive regulation of platelet activation	GO:010572	9.9	TLR4, SELP
15	defense response to Gram-negative bacterium	GO:050829	9.2	SELP, SERPINE1, TLR4
16	response to hypoxia	GO:001666	8.7	MMP9, MB, TLR4, NPPB, RYR2
17	blood coagulation	GO:007596	8.2	ATP2A2, SELPLG, SELP, FGA, CXADR, SERPINE1
18	SA node cardiomyocyte to atrial cardiomyocyte communication	GO:086070	INF	, SCN5A
19	regulation of ventricular cardiac muscle cell action potential	GO:086005	INF	SCN5A, , RYR2
20	regulation of ventricular cardiomyocyte membrane depolarization	GO:060373	INF	, SCN5A
21	heart development	GO:007507	INF	, MB, CXADR, NPPB
22	membrane depolarization involved in regulation of action potential	GO:086010	INF	SCN5A,
23	response to lipopolysaccharide	GO:032496	INF	TLR4, SELP, , MMP9
24	regulation of potassium ion transport	GO:043266	INF	, DPP6
25	regulation of ventricular cardiomyocyte membrane repolarization	GO:060307	INF	SCN5A,

Molecular functions related to ventricular fibrillation according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	GO:086006	INF	, SCN5A,
2	ryanodine-sensitive calcium-release channel activity	GO:005219	10.1	RYR2, FKBP1B
3	receptor binding	GO:005102	7.8	SELPLG, NPPB, CXADR, GLA, FGA, FKBP1B
4	inward rectifier potassium channel activity	GO:005242	INF	KCNJ2, KCNJ5,