MCID: VNT002
MIFTS: 60

Ventricular Septal Defect malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Ventricular Septal Defect

About this section

Aliases & Descriptions for Ventricular Septal Defect:

Name: Ventricular Septal Defect 11 13
Ventricular Septal Defects 48 27 50
Heart Septal Defects, Ventricular 48 39
 
Interventricular Septal Defect 11
Ventricular Septal Abnormality 11

Classifications:



External Ids:

Disease Ontology11 DOID:1657
ICD1030 Q21.0
ICD9CM32 745.4
MeSH39 D006345
NCIt45 C84506

Summaries for Ventricular Septal Defect

About this section
Disease Ontology:11 A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles.

MalaCards based summary: Ventricular Septal Defect, also known as ventricular septal defects, is related to ichthyosis and ventricular septal defect 3. An important gene associated with Ventricular Septal Defect is NKX2-5 (NK2 Homeobox 5), and among its related pathways are HOP Signaling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include heart, lung and liver, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and limbs/digits/tail.

Wikipedia:71 A ventricular septal defect (VSD) is a defect in the ventricular septum, the wall dividing the left and... more...

Related Diseases for Ventricular Septal Defect

About this section

Diseases in the Ventricular Septal Defect family:

Ventricular Septal Defect 3 Ventricular Septal Defect 2
Ventricular Septal Defect 1

Diseases related to Ventricular Septal Defect via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis28.3CITED2, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
2ventricular septal defect 312.4
3ventricular septal defect 212.4
4ventricular septal defect 112.4
5pulmonary atresia with ventricular septal defect12.3
6pulmonary valve agenesis-ventricular septal defect-persistent ductus arteriosus syndrome12.0
7double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis12.0
8double outlet right ventricle with non-committed subpulmonary ventricular septal defect12.0
9tetralogy of fallot11.9
10laubry-pezzi syndrome11.5
11tricuspid atresia11.3
12eisenmenger syndrome11.3
13cor triatriatum11.2
14conotruncal heart malformations11.1
15heterotaxy, visceral, 1, x-linked11.0
16hirschsprung disease polydactyly heart disease11.0
17laurence prosser rocker syndrome11.0
18hirschsprung disease, cardiac defects, and autonomic dysfunction10.9
19transposition of the great arteries, dextro-looped 210.9
20adams-oliver syndrome 110.9
21ritscher-schinzel syndrome10.9
22adams-oliver syndrome 510.9
23heterotaxy, visceral, 510.9
24joubert syndrome 1810.9
25warsaw breakage syndrome10.9
26transposition of the great arteries, dextro-looped 110.9
27adams-oliver syndrome 610.9
28congenital heart defects, multiple types, 410.9
29left ventricular noncompaction 1, with or without congenital heart defects10.9
30transposition of great arteries, dextro-looped 310.9
31right atrial isomerism10.9
32microphthalmia, syndromic 210.9
33goldberg-shprintzen megacolon syndrome10.9
34pancreatic agenesis and congenital heart defects10.9
35short stature, developmental delay, and congenital heart defects10.9
36gerbode defect10.6
37transposition of the great arteries10.6
38myocardial infarction10.4
39left ventricular outflow tract obstruction10.4
40aneurysm10.4
41endocarditis10.4
42patent ductus arteriosus10.4
43aortic valve prolapse10.3
44pulmonary hypertension10.3
45pulmonic stenosis10.3
46persistent eustachian valve10.3GATA4, GATA6
47aortic coarctation10.2
48congenital benign spinal muscular atrophy dominant10.2GATA4, GATA6
49dextrocardia10.2
50congenitally corrected transposition of the great arteries10.2

Graphical network of the top 20 diseases related to Ventricular Septal Defect:



Diseases related to ventricular septal defect

Symptoms & Phenotypes for Ventricular Septal Defect

About this section

GenomeRNAi Phenotypes related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1928.9CITED2, GATA6, NODAL, TBX5

MGI Mouse Phenotypes related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5CITED2, GATA4, GATA6, HOMEZ, ISL1, NFATC1
2MP:00053828.1CITED2, GDF1, ISL1, JAG1, NFATC1, NKX2-5
3MP:00053707.9GATA4, GATA6, GDF1, JAG1, NFATC1, NODAL
4MP:00030127.7GATA4, ISL1, JAG1, MYH7, NFATC1, NKX2-5
5MP:00053887.5CITED2, GATA4, GATA6, GDF1, NFATC1, NKX2-5
6MP:00053797.4CITED2, GATA4, GATA5, GDF1, ISL1, JAG1
7MP:00028737.0CITED2, GATA4, GATA6, GDF1, ISL1, JAG1
8MP:00053816.7CITED2, GATA4, GATA5, GDF1, ISL1, JAG1
9MP:00053806.5BCOR, CITED2, GATA4, GATA6, GDF1, ISL1
10MP:00053906.5CITED2, GATA4, GATA5, GDF1, HOMEZ, ISL1
11MP:00053786.4BCOR, CITED2, GATA4, GATA6, GDF1, ISL1
12MP:00053766.3CITED2, GATA4, GATA5, GATA6, ISL1, JAG1
13MP:00053696.2GATA4, GATA5, GATA6, ISL1, JAG1, MYH7
14MP:00053845.8CITED2, GATA4, GATA5, GATA6, GDF1, ISL1
15MP:00107685.0BCOR, CITED2, GATA4, GATA5, GATA6, GDF1
16MP:00053854.6BCOR, CITED2, GATA4, GATA5, GATA6, GDF1

Drugs & Therapeutics for Ventricular Septal Defect

About this section

Drugs for Ventricular Septal Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 80)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 123689
2Adrenergic AgentsPhase 4, Phase 3, Phase 15352
3Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 118340
4Adrenergic AgonistsPhase 4, Phase 3, Phase 13027
5Adrenergic beta-AgonistsPhase 41714
6Tocolytic AgentsPhase 4739
7Adrenergic beta-2 Receptor AgonistsPhase 4957
8Respiratory System AgentsPhase 44997
9Bronchodilator AgentsPhase 42965
10AlbuterolPhase 4429
11Anti-Asthmatic AgentsPhase 43488
12Autonomic AgentsPhase 410150
13
Bosentanapproved, investigationalPhase 3104147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
DB00559
 
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentan
bosentanum
bosentán
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
14
Dexmedetomidineapproved, vet_approvedPhase 3, Phase 159276631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
15
EnalaprilatapprovedPhase 312476420-72-96917719
Synonyms:
(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid dihydrate
1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
76420-72-9
AC1NUWEA
AC1OCEK7
BIDD:GT0752
C11720
C18H24N2O5.2H2O
CHEBI:116759
CHEBI:42302
CHEBI:4786
CHEBI:59877
CHEMBL1200697
CHEMBL577
CID5462501
CID6917719
CPD000466359
D03769
EAL
ENALAPRILAT INHIBITOR
Enalapril acid
Enalapril diacid
Enalaprilat
Enalaprilat (USP)
 
Enalaprilat anhydrous
Enalaprilate
Enalaprilatum
Enalaprilic acid
Enalprilate hydrate
HMS2051H16
HMS2089P04
LS-118903
LS-187219
MK-422
MLS000759476
MLS001424138
MolPort-005-943-792
N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2)
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline—water (1/2)
NCGC00164593-01
S1657_Selleck
SAM001246684
SBB065733
SMR000466359
Vasotec I.V.
enalaprilat dihydrate
enalaprilat hydrate
enalprilat hydrate
enalprilate hydrate
16
Enalaprilapproved, vet_approvedPhase 312475847-73-35362032, 40466924
Synonyms:
(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
(S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
(S)-1-{(S)-2-[1-((S)-ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
75847-73-3
AC1NTUS5
Analapril
BIDD:GT0751
BPBio1_000340
BSPBio_000308
BSPBio_003035
Bonuten
C06977
CAS-76095-16-4
CHEBI:116847
CHEBI:4784
CHEMBL578
CID5388962
D07892
DivK1c_000408
Enalapril
Enalapril (INN)
Enalapril (TN)
Enalapril Bp
Enalapril Maleate
Enalapril Richet
Enalaprila
Enalaprila [INN-Spanish]
Enalaprilat
Enalaprilum
 
Enalaprilum [INN-Latin]
Gadopril
HMS2090E08
IDI1_000408
KBio1_000408
KBio2_001787
KBio2_004355
KBio2_006923
KBio3_002535
KBioGR_000355
KBioSS_001787
Kinfil
LS-190651
MolPort-002-885-877
N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline
NCGC00016932-01
NCGC00021569-04
NCGC00021569-05
NCGC00021569-06
NINDS_000408
Prestwick3_000314
SPBio_001349
Spectrum2_001455
Spectrum3_001478
Spectrum4_000008
Spectrum5_001107
Spectrum_001307
Vaseretic
Vasotec
Vasotec IV
enalapril
17Central Nervous System DepressantsPhase 3, Phase 2, Phase 113403
18Hypnotics and SedativesPhase 3, Phase 12616
19Analgesics, Non-NarcoticPhase 3, Phase 16501
20Endothelin Receptor AntagonistsPhase 3218
21Antihypertensive AgentsPhase 34207
22AnalgesicsPhase 3, Phase 2, Phase 111733
23Adrenergic alpha-2 Receptor AgonistsPhase 3, Phase 1980
24Adrenergic alpha-AgonistsPhase 3, Phase 11734
25
protease inhibitorsPhase 35471
Synonyms:
 
protease inhibitors
26HIV Protease InhibitorsPhase 35470
27Angiotensin-Converting Enzyme InhibitorsPhase 3724
28
Ketamineapproved, vet_approvedPhase 25696740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
 
DEA No. 7285
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
Kétamine
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine
29
MilrinoneapprovedPhase 1, Phase 23578415-72-24197
Synonyms:
-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4&prime
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
111GE027
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
78415-72-2
AB00514027
AC-4730
AC1L1HMP
AC1Q2EBX
BIDD:GT0197
BPBio1_001156
BRN 3546821
BSPBio_001050
C07224
C12H9N3O
CAS-78415-72-2
CCRIS 3795
CHEBI:50693
CHEMBL189
CID4197
CPD000058475
Corotrop
Corotrope
D00417
DB00235
EINECS 278-903-6
EN002063
EU-0100737
HMS1571E12
HMS2051L10
HMS2090J14
I06-0259
LS-44610
Lopac-M-4659
Lopac0_000737
 
M 4659
M1663
M4659_SIGMA
MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER
MLS000028818
MLS001424052
Milrila
Milrila (TN)
Milrinona
Milrinona [Spanish]
Milrinone
Milrinone (JAN/USAN/INN)
Milrinone Lactate
Milrinone [USAN:BAN:INN]
Milrinonum
Milrinonum [Latin]
NCGC00015675-01
NCGC00015675-02
NCGC00015675-04
NCGC00015675-07
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00164390-01
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Primacor
S2484_Selleck
SAM001246611
SBB055743
SMR000058475
SPBio_002965
Tocris-1504
UNII-JU9YAX04C7
WIN 47203-2
Win-47203
Win-47203-2
YM 018
ZINC09224016
milrinone
30Sildenafil CitratePhase 1, Phase 2331171599-83-0
31Protective AgentsPhase 1, Phase 27443
32Platelet Aggregation InhibitorsPhase 1, Phase 22516
33Pharmaceutical SolutionsPhase 28192
34Plasma SubstitutesPhase 2240
35DextransPhase 2104
36Blood SubstitutesPhase 2253
37AnticoagulantsPhase 22623
38Vasodilator AgentsPhase 1, Phase 23543
39Phosphodiesterase InhibitorsPhase 1, Phase 21289
40Anesthetics, IntravenousPhase 22538
41Anesthetics, GeneralPhase 22934
42AnestheticsPhase 29596
43Phosphodiesterase 5 InhibitorsPhase 1, Phase 2589
44Excitatory Amino Acid AntagonistsPhase 21347
45Anesthetics, DissociativePhase 2544
46Phosphodiesterase 3 InhibitorsPhase 1, Phase 2133
47Excitatory Amino AcidsPhase 21362
48
Citric Acidnutraceutical, vet_approvedPhase 1, Phase 2116077-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
49CitrateNutraceuticalPhase 1, Phase 21160
50
Nitric OxideapprovedPhase 161710102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique

Interventional clinical trials:

(show top 50)    (show all 61)
idNameStatusNCT IDPhase
1The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.Not yet recruitingNCT02914652Phase 4
2Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
3Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.CompletedNCT01218607Phase 3
4The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart DiseaseCompletedNCT00480740Phase 3
5Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal DefectRecruitingNCT02644330Phase 2, Phase 3
6Safety and Effectiveness of the Nit-Occlud® Lê VSD Spiral Coil SystemSuspendedNCT00390702Phase 2, Phase 3
7Angiotensin Converting Enzyme Inhibition in Children With Mitral RegurgitationTerminatedNCT00113698Phase 3
8Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised ProtocolCompletedNCT01120964Phase 1, Phase 2
9Use of Ketamine Prior to Cardiopulmonary Bypass in ChildrenCompletedNCT00556361Phase 2
10Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary HypertensionCompletedNCT02595541Phase 1, Phase 2
11Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
12Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular SeptumCompletedNCT01609738Phase 1, Phase 2
13Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left VentricleNot yet recruitingNCT03079401Phase 1, Phase 2
14Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood FlowUnknown statusNCT01825369Phase 1
15Closure of Muscular Ventricular Septal Defects With The AMPLATZER® Muscular VSD OccluderUnknown statusNCT00583791Phase 1
16Closure of Perimembranous Ventricular Septal Defects With The AMPLATZER® Membranous VSD OCCLUDERCompletedNCT00578708Phase 1
17A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
18Radiation-Free Heart Catheterization Using MRIRecruitingNCT02739087Phase 1
19Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic AccessEnrolling by invitationNCT02280824Phase 1
20Study of Energy Expenditure in Infants With Ventricular Septal DefectsUnknown statusNCT00006272
21Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal DefectUnknown statusNCT00173186
22Pivotal Study of a Percutaneous Mitral Valve Repair SystemUnknown statusNCT00209274
23Emergency/Compassionate Use - Muscular VSD OccluderApproved for marketingNCT00590382
24Transcatheter Closure Versus Surgery of Perimembranous Ventricular Septal DefectsCompletedNCT00890799
25Right Bundle Branch Block After Surgical Closure of Ventricular Septal DefectCompletedNCT01480908
26Longterm Outcome After Ventricular Septal Defect ClosureCompletedNCT02138435
27Hybrid Closure of Congenital Heart DiseaseCompletedNCT02794584
28A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
29Evaluation of Dynamic Pulmonary Vascular Resistance in Patients With Closed Ventricular Septal DefectCompletedNCT02648984
30The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary HypertensionCompletedNCT01313832
31Molecular Genetic Epidemiology of Three Cardiac Defects -SCOR in Pediatric Cardiovascular DiseaseCompletedNCT00005546
32Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular DiseaseCompletedNCT00005322
33Evaluation of Latent Pulmonary Arterial Hypertension in Congenital Shunt LesionsCompletedNCT02552485
34Measures to Lower the Stress Response in Pediatric Cardiac SurgeryCompletedNCT00848393
35Bupropion & Cardio Birth Defect (Slone)CompletedNCT01597661
36Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
37Quality of Life in Young Adults With Congenital Heart DiseaseCompletedNCT02463292
38Follow up of Post-repair Tetralogy of FallotCompletedNCT00266188
39Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patients With Shunt or Chronic Obstructive Pulmonary DiseaseCompletedNCT02449083
40Acetaminophen for Oxidative Stress After Cardiopulmonary BypassCompletedNCT01228305
41Genes Causing Ebstein's AnomalyCompletedNCT00497705
42Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle PhysiologyCompletedNCT01563757
43EVEREST II Pivotal Study High Risk Registry (HRR)CompletedNCT01940120
44Cardiac Function After Transcatheter VSD ClosureRecruitingNCT03127748
45Choice of Palliative Procedures for Pulmonary Atresia With Ventricular Septal Defect PatientsRecruitingNCT02861963
46Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder - Post Approval StudyRecruitingNCT00647387
47Extended Criteria For Fetal Myelomeningocele RepairRecruitingNCT02664207
48Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility StudyRecruitingNCT03022708
49MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect ClosureRecruitingNCT03024268
50Stress Echo 2020 - The International Stress Echo StudyRecruitingNCT03049995

Search NIH Clinical Center for Ventricular Septal Defect


Cochrane evidence based reviews: heart septal defects, ventricular

Genetic Tests for Ventricular Septal Defect

About this section

Genetic tests related to Ventricular Septal Defect:

id Genetic test Affiliating Genes
1 Ventricular Septal Defect27

Anatomical Context for Ventricular Septal Defect

About this section

MalaCards organs/tissues related to Ventricular Septal Defect:

36
Heart, Lung, Liver, Brain, Pineal, Colon

Publications for Ventricular Septal Defect

About this section

Articles related to Ventricular Septal Defect:

(show top 50)    (show all 1073)
idTitleAuthorsYear
1
Interventricular septal hematoma following repair of a ventricular septal defect. (28493392)
2017
2
Severe pulmonary arterial hypertension in a patient with small ventricular septal defect. (28077486)
2017
3
Ventricular Septal Defect Complicating ST-Elevation Myocardial Infarctions: A Call for Action. (28065768)
2017
4
Significant survival advantage of high pulmonary vein index and the presence of native pulmonary artery in pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries: results from preoperative computed tomography angiography. (28369397)
2017
5
Bilateral Coronary-Pulmonary Artery Fistulas in Pulmonary Atresia With Ventricular Septal Defect. (28496023)
2017
6
Right-to-left shunting through the unidirectional valved patch after closure of ventricular septal defect. (28393787)
2017
7
Aortic valve prolapse misdiagnosed as aortic sinus aneurysm in patients with ventricular septal defect. Analysis of the echocardiographic findings. (28397952)
2017
8
Percutaneous Perventricular Device Closure of Ventricular Septal Defect: From Incision to Pinhole. (27884409)
2017
9
Simultaneous transcatheter therapy for perimembranous ventricular septal defect combined with patent ductus arteriosus. (28497553)
2017
10
Major Aortopulmonary Collateral Arteries With Anatomy Other Than Pulmonary Atresia/Ventricular Septal Defect. (28527961)
2017
11
A successful cesarean delivery without fetal or maternal morbidity in an Eisenmenger patient with cor triatriatum sinistrum, double-orifice mitral valve, large ventricular septal defect, and single ventricle who was under long-term bosentan treatment. (28424444)
2017
12
Transcatheter closure of a membranous ventricular septal defect in a 1.8-kg infant using Amplatzer Duct Occluder II additional size device. (28506322)
2017
13
Impaired ventilatory efficiency after closure of atrial or ventricular septal defect. (28502187)
2017
14
Gerbode Ventricular Septal Defect -A Rare Cardiac Anomaly Associated with Genetic Variants in Indian Population- A Case Series. (28511407)
2017
15
Transcatheter device closure of postmyocardial infarction ventricular septal defect. (27889458)
2017
16
Perventricular double-device closure of wide-spaced multi-hole perimembranous ventricular septal defect. (28412961)
2017
17
Left Ventricular Noncompaction With Muscular Ventricular Septal Defect in Mother and Son. (28520539)
2017
18
Does morphological vessel analysis address pulmonary vascular physiology in patients with pulmonary atresia, ventricular septal defect and major aortopulmonary collateral arteries? (28472241)
2017
19
Evaluation of Ventricular Septal Defect with Special Reference to the Spontaneous Closure Rate, Subaortic Ridge, and Aortic Valve Prolapse II. (28401252)
2017
20
Postoperative interventricular septal haematoma following tetralogy of Fallot repair and perimembranous ventricular septal defect repair. (28364481)
2017
21
Identification of a novel and functional mutation in the TBX5 gene in a patient by screening from 354 patients with isolated ventricular septal defect. (28434921)
2017
22
Directly ventricular septal defect closure without using arteriovenous wire loop: Our adult case series using transarterial retrograde approach. (28529295)
2017
23
Perventricular device closure of perimembranous ventricular septal defect: effectiveness of symmetric and asymmetric occluders. (28082474)
2017
24
Ventricular septal defect. (27435668)
2016
25
A case of acute myocardial infarction after successful transcatheter closure of ventricular septal defect. (28533728)
2016
26
Altering management decisions with gained anatomical insight from a 3D printed model of a complex ventricular septal defect. (27869052)
2016
27
Aortic Translocation for Repair of Transposition of the Great Arteries (S,D,L) With Ventricular Septal Defect and Pulmonic Stenosis. (26694279)
2016
28
Successful Closure of a Ventricular Septal Defect Using a Novel Non-Prosthesis Touching Technique Following Mechanical Aortic Valve Replacement. (27829962)
2016
29
Closure of a high ventricular septal defect after transcatheter aortic valve implantation with an atrial septal occluder-hybrid treatment for a rare complication. (27655741)
2016
30
Complete Preoperative Evaluation of Pulmonary Atresia with Ventricular Septal Defect with Multi-Detector Computed Tomography. (26741649)
2016
31
Ventricular Septal Defect from Aortic Regurgitation Jet Lesion in Aortic Valve Infective Endocarditis. (27989057)
2016
32
Unidirectional ventricular septal valved patch for repair of late presenting ventricular septal defect with aortopulmonary window. (27011704)
2016
33
Medium to long-term echo follow-up after ventricular septal defect device closure. (27112358)
2016
34
An (In)Significant Ventricular Septal Defect and/or Double-Chambered Right Ventricle: Are There Any Differences in Diagnosis and Prognosis in Adult Patients. (27111550)
2016
35
Severe aortic regurgitation during percutaneous closure of ventricular septal defect. (27131265)
2016
36
Clinical Application and Multidisciplinary Assessment of Three Dimensional Printing in Double Outlet Right Ventricle With Remote Ventricular Septal Defect. (27142402)
2016
37
Long-term outcome after treatment of pulmonary atresia with ventricular septal defect: nationwide study of 109 patients born in 1970-2007. (26620210)
2016
38
Utility of the Gore Septal Occluder in Transcatheter Closure of Post-Myocardial Infarct Ventricular Septal Defect: Initial Experience. (27832852)
2016
39
Right Heart Function of Fetuses and Infants with Large Ventricular Septal Defect: A Longitudinal Case-Control Study. (27562129)
2016
40
Double Aortic Arch Associated with Pulmonary Atresia with Ventricular Septal Defect. (27074277)
2016
41
Pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries: primary repair. (26811506)
2016
42
Absent Pulmonary Valve Syndrome With Tricuspid Atresia, Ventricular Septal Defect, and Aneurysmal Dilated Pulmonary Artery: A Case Report of Successful Fontan Completion. (27549733)
2016
43
Repair of Posterior Infarct Ventricular Septal Defect in a Patient with Dextrocardia and Situs Inversus. (26785697)
2016
44
Prediction of Fluid Responsiveness Using Pulse Pressure Variation in Infants Undergoing Ventricular Septal Defect Repair with Median Sternotomy or Minimally Invasive Right Thoracotomy. (27837303)
2016
45
Post-myocardial infarction ventricular septal defect. Is it better to operate on a fresh infarction or to wait? A case study. (27212977)
2016
46
Sudden infant deaths from undiagnosed ventricular septal defect - Report of two autopsy cases. (27591530)
2016
47
Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence. (27173869)
2016
48
Double Outlet Right Ventricle with Noncommitted Ventricular Septal Defect and Two Adequate Ventricles: is Anatomical Repair Advantageous? (27568140)
2016
49
Achievements and Limitations of a Strategy of Rehabilitation of Native Pulmonary Vessels in Pulmonary Atresia, Ventricular Septal Defect, and Major Aortopulmonary Collateral Arteries. (28010875)
2016
50
Double-Outlet Right Ventricle With Noncommitted Ventricular Septal Defect and 2 Adequate Ventricles: Is Anatomical Repair Advantageous? (27568139)
2016

Variations for Ventricular Septal Defect

About this section

Expression for genes affiliated with Ventricular Septal Defect

About this section
Search GEO for disease gene expression data for Ventricular Septal Defect.

Pathways for genes affiliated with Ventricular Septal Defect

About this section

GO Terms for genes affiliated with Ventricular Septal Defect

About this section

Cellular components related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056547.9CITED2, GATA4, GATA5, GATA6, ISL1, NFATC1
2nucleusGO:00056345.9BCOR, CITED2, GATA4, GATA5, GATA6, HOMEZ

Biological processes related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1cardiac ventricle morphogenesisGO:000320810.9GATA4, NKX2-5
2bundle of His developmentGO:000316610.9NKX2-5, TBX5
3atrial cardiac muscle cell developmentGO:005501410.9NKX2-5, NKX2-6
4endocardial cushion developmentGO:000319710.9GATA4, TBX5
5pericardium developmentGO:006003910.8NKX2-6, TBX5
6adult heart developmentGO:000751210.8MYH7, NKX2-5
7endocardial cushion morphogenesisGO:000320310.7ISL1, TWIST1
8cardiac muscle hypertrophy in response to stressGO:001489810.7GATA6, MYH7
9embryonic heart tube left/right pattern formationGO:006097110.6CITED2, NKX2-5
10pharyngeal system developmentGO:006003710.6ISL1, NKX2-5, NKX2-6
11cardiac neural crest cell development involved in outflow tract morphogenesisGO:006130910.6JAG1, TWIST1
12right ventricular cardiac muscle tissue morphogenesisGO:000322110.5NKX2-5, ZFPM2
13ventricular cardiac muscle cell developmentGO:005501510.5NKX2-5, NKX2-6
14cardiac muscle cell differentiationGO:005500710.4GATA4, GATA6, NKX2-5, TBX5
15cardiac right ventricle morphogenesisGO:000321510.4GATA4, ISL1, JAG1
16atrial septum morphogenesisGO:006041310.4GATA4, ISL1, NKX2-5, TBX5
17positive regulation of cardioblast differentiationGO:005189110.4GATA4, GATA6, NKX2-5, TBX5
18outflow tract morphogenesisGO:000315110.4CITED2, ISL1, NKX2-5
19cardiac muscle tissue developmentGO:004873810.3GATA6, NKX2-5, ZFPM2
20positive regulation of male gonad developmentGO:200002010.3CITED2, ZFPM2
21positive regulation of cardiac muscle cell proliferationGO:006004510.3GATA6, TBX5, ZFPM2
22heart loopingGO:000194710.3GATA4, NKX2-5, NODAL
23ventricular cardiac muscle tissue morphogenesisGO:005501010.3ISL1, MYH7
24embryonic heart tube developmentGO:003505010.3NKX2-5, NKX2-6, NODAL
25nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryGO:190016410.2CITED2, NODAL
26positive regulation of cell-cell adhesionGO:002240910.2CITED2, NODAL
27positive regulation of vascular endothelial growth factor productionGO:001057510.2GATA4, ISL1, NODAL
28BMP signaling pathwayGO:003050910.1GDF1, NKX2-5, NODAL
29outflow tract septum morphogenesisGO:000314810.0GATA6, ISL1, NKX2-5, ZFPM2
30intestinal epithelial cell differentiationGO:006057510.0GATA4, GATA5, GATA6
31liver developmentGO:000188910.0CITED2, GATA6, NODAL
32negative regulation of cell differentiationGO:00455969.9JAG1, NODAL, TWIST1
33lung developmentGO:00303249.9NODAL, TBX5, ZFPM2
34negative regulation of apoptotic processGO:00430669.8CITED2, GATA6, NKX2-5, NKX2-6, TWIST1
35positive regulation of angiogenesisGO:00457669.6GATA4, GATA6, ISL1, NODAL, TWIST1
36in utero embryonic developmentGO:00017019.6GATA6, NODAL, TWIST1, ZFPM2
37blood coagulationGO:00075969.5GATA4, GATA5, GATA6, ZFPM2
38ventricular septum morphogenesisGO:00604129.3CITED2, NKX2-5, ZFPM2
39negative regulation of transcription, DNA-templatedGO:00458929.0BCOR, CITED2, GATA6, NKX2-5, TWIST1, ZFPM2
40multicellular organism developmentGO:00072758.6CITED2, ISL1, JAG1, NKX2-5, NKX2-6, NODAL
41positive regulation of transcription, DNA-templatedGO:00458938.3CITED2, GATA4, GATA5, GATA6, NFATC1, NKX2-5
42heart developmentGO:00075078.3BCOR, CITED2, ISL1, NKX2-5, NKX2-6, NODAL
43transcription from RNA polymerase II promoterGO:00063668.2CITED2, GATA4, GATA5, GATA6, ISL1, NFATC1
44negative regulation of transcription from RNA polymerase II promoterGO:00001227.8BCOR, CITED2, GATA6, HOMEZ, ISL1, NKX2-5
45transcription, DNA-templatedGO:00063516.8BCOR, CITED2, GATA4, GATA5, GATA6, HOMEZ
46positive regulation of transcription from RNA polymerase II promoterGO:00459446.7CITED2, GATA4, GATA5, GATA6, ISL1, JAG1
47regulation of transcription, DNA-templatedGO:00063556.6BCOR, CITED2, GATA4, GATA5, GATA6, HOMEZ

Molecular functions related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:004342510.7ISL1, TWIST1
2RNA polymerase II transcription coactivator activityGO:000110510.0CITED2, ISL1, ZFPM2
3enhancer sequence-specific DNA bindingGO:00011589.9GATA4, GATA5, ISL1
4transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037059.6GATA5, GATA6, NFATC1, NKX2-5
5transcription corepressor activityGO:00037149.4BCOR, CITED2, HOMEZ, ZFPM2
6RNA polymerase II transcription factor bindingGO:00010859.1GATA4, GATA5, GATA6, NFATC1, ZFPM2
7chromatin bindingGO:00036829.1CITED2, GATA4, GATA5, GATA6, ISL1, NKX2-5
8sequence-specific DNA bindingGO:00435659.0GATA4, GATA5, GATA6, ISL1, NKX2-5, NKX2-6
9transcription regulatory region DNA bindingGO:00442129.0BCOR, GATA4, GATA5, GATA6, NKX2-5
10RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009778.9BCOR, GATA4, GATA5, GATA6, NFATC1, TBX5
11transcription factor bindingGO:00081348.9BCOR, GATA4, GATA6, NKX2-5, TBX5, TWIST1
12transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012288.8GATA4, GATA5, GATA6, NKX2-5, TBX5
13transcription factor activity, sequence-specific DNA bindingGO:00037007.8CITED2, GATA4, GATA5, GATA6, HOMEZ, NFATC1
14DNA bindingGO:00036777.8GATA4, GATA5, GATA6, HOMEZ, ISL1, NFATC1

Sources for Ventricular Septal Defect

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet