MCID: VNT002
MIFTS: 59

Ventricular Septal Defect malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Ventricular Septal Defect

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Aliases & Descriptions for Ventricular Septal Defect:

Name: Ventricular Septal Defect 11 13
Ventricular Septal Defects 47 26 49
Heart Septal Defects, Ventricular 47 38
 
Interventricular Septal Defect 11
Ventricular Septal Abnormality 11

Classifications:



External Ids:

Disease Ontology11 DOID:1657
ICD1029 Q21.0
ICD9CM31 745.4
MeSH38 D006345
NCIt44 C84506

Summaries for Ventricular Septal Defect

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Disease Ontology:11 A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles.

MalaCards based summary: Ventricular Septal Defect, also known as ventricular septal defects, is related to adams-oliver syndrome 5 and ventricular septal defect 3. An important gene associated with Ventricular Septal Defect is NKX2-5 (NK2 Homeobox 5), and among its related pathways are HOP Signaling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include heart, lung and liver, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Wikipedia:70 A ventricular septal defect (VSD) is a defect in the ventricular septum, the wall dividing the left and... more...

Related Diseases for Ventricular Septal Defect

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Diseases in the Ventricular Septal Defect family:

Ventricular Septal Defect 3 Ventricular Septal Defect 2
Ventricular Septal Defect 1

Diseases related to Ventricular Septal Defect via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1adams-oliver syndrome 530.9NKX2-6, NPPB, TWIST1
2ventricular septal defect 312.4
3ventricular septal defect 212.4
4ventricular septal defect 112.4
5pulmonary atresia with ventricular septal defect12.3
6pulmonary valve agenesis-ventricular septal defect-persistent ductus arteriosus syndrome12.0
7double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis12.0
8double outlet right ventricle with non-committed subpulmonary ventricular septal defect12.0
9tetralogy of fallot11.9
10laubry-pezzi syndrome11.5
11tricuspid atresia11.3
12cor triatriatum11.3
13conotruncal heart malformations11.1
14heterotaxy, visceral, 1, x-linked11.1
15hirschsprung disease polydactyly heart disease11.0
16laurence prosser rocker syndrome11.0
17hirschsprung disease, cardiac defects, and autonomic dysfunction10.9
18transposition of the great arteries, dextro-looped 210.9
19adams-oliver syndrome 110.9
20ritscher-schinzel syndrome10.9
21heterotaxy, visceral, 510.9
22joubert syndrome 1810.9
23warsaw breakage syndrome10.9
24transposition of the great arteries, dextro-looped 110.9
25adams-oliver syndrome 610.9
26congenital heart defects, multiple types, 410.9
27left ventricular noncompaction 1, with or without congenital heart defects10.9
28transposition of great arteries, dextro-looped 310.9
29right atrial isomerism10.9
30microphthalmia, syndromic 210.9
31goldberg-shprintzen megacolon syndrome10.9
32pancreatic agenesis and congenital heart defects10.9
33short stature, developmental delay, and congenital heart defects10.9
34gerbode defect10.6
35transposition of the great arteries10.6
36straddling and/or overriding mitral valve10.6GATA4, GATA6
37partial duplication of the short arm of chromosome x10.5GATA4, GATA6
38left ventricular outflow tract obstruction10.4
39myocardial infarction10.4
40aneurysm10.4
41endocarditis10.4
42patent ductus arteriosus10.3
43d-glycericacidemia10.3CITED2, NODAL
44pulmonary hypertension10.3
45pulmonic stenosis10.3
46aortic valve prolapse10.3
47drug-induced vasculitis10.3GATA4, ZFPM2
48aortic coarctation10.2
49eisenmenger syndrome10.2
50dextrocardia10.2

Graphical network of the top 20 diseases related to Ventricular Septal Defect:



Diseases related to ventricular septal defect

Symptoms for Ventricular Septal Defect

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Drugs & Therapeutics for Ventricular Septal Defect

About this section

Drugs for Ventricular Septal Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 78)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 122776
2Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 117734
3Adrenergic AgentsPhase 4, Phase 3, Phase 15140
4Adrenergic AgonistsPhase 4, Phase 3, Phase 12877
5Tocolytic AgentsPhase 4708
6Bronchodilator AgentsPhase 42856
7Respiratory System AgentsPhase 44818
8Autonomic AgentsPhase 49774
9Adrenergic beta-2 Receptor AgonistsPhase 4925
10Adrenergic beta-AgonistsPhase 41640
11AlbuterolPhase 4408
12Anti-Asthmatic AgentsPhase 43369
13
Bosentanapproved, investigationalPhase 3103147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
DB00559
 
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentan
bosentanum
bosentán
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
14
Dexmedetomidineapproved, vet_approvedPhase 3, Phase 154076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
15
EnalaprilatapprovedPhase 312076420-72-96917719
Synonyms:
(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid dihydrate
1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
76420-72-9
AC1NUWEA
AC1OCEK7
BIDD:GT0752
C11720
C18H24N2O5.2H2O
CHEBI:116759
CHEBI:42302
CHEBI:4786
CHEBI:59877
CHEMBL1200697
CHEMBL577
CID5462501
CID6917719
CPD000466359
D03769
EAL
ENALAPRILAT INHIBITOR
Enalapril acid
Enalapril diacid
Enalaprilat
Enalaprilat (USP)
 
Enalaprilat anhydrous
Enalaprilate
Enalaprilatum
Enalaprilic acid
Enalprilate hydrate
HMS2051H16
HMS2089P04
LS-118903
LS-187219
MK-422
MLS000759476
MLS001424138
MolPort-005-943-792
N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2)
N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline—water (1/2)
NCGC00164593-01
S1657_Selleck
SAM001246684
SBB065733
SMR000466359
Vasotec I.V.
enalaprilat dihydrate
enalaprilat hydrate
enalprilat hydrate
enalprilate hydrate
16
Enalaprilapproved, vet_approvedPhase 312075847-73-35362032, 40466924
Synonyms:
(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
(S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
(S)-1-{(S)-2-[1-((S)-ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
75847-73-3
AC1NTUS5
Analapril
BIDD:GT0751
BPBio1_000340
BSPBio_000308
BSPBio_003035
Bonuten
C06977
CAS-76095-16-4
CHEBI:116847
CHEBI:4784
CHEMBL578
CID5388962
D07892
DivK1c_000408
Enalapril
Enalapril (INN)
Enalapril (TN)
Enalapril Bp
Enalapril Maleate
Enalapril Richet
Enalaprila
Enalaprila [INN-Spanish]
Enalaprilat
Enalaprilum
 
Enalaprilum [INN-Latin]
Gadopril
HMS2090E08
IDI1_000408
KBio1_000408
KBio2_001787
KBio2_004355
KBio2_006923
KBio3_002535
KBioGR_000355
KBioSS_001787
Kinfil
LS-190651
MolPort-002-885-877
N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline
NCGC00016932-01
NCGC00021569-04
NCGC00021569-05
NCGC00021569-06
NINDS_000408
Prestwick3_000314
SPBio_001349
Spectrum2_001455
Spectrum3_001478
Spectrum4_000008
Spectrum5_001107
Spectrum_001307
Vaseretic
Vasotec
Vasotec IV
enalapril
17AnalgesicsPhase 3, Phase 2, Phase 111287
18Analgesics, Non-NarcoticPhase 3, Phase 16260
19Hypnotics and SedativesPhase 3, Phase 12485
20Central Nervous System DepressantsPhase 3, Phase 2, Phase 112806
21Endothelin Receptor AntagonistsPhase 3215
22Adrenergic alpha-2 Receptor AgonistsPhase 3, Phase 1911
23Antihypertensive AgentsPhase 34095
24Adrenergic alpha-AgonistsPhase 3, Phase 11625
25
protease inhibitorsPhase 35320
Synonyms:
 
protease inhibitors
26HIV Protease InhibitorsPhase 35319
27Angiotensin-Converting Enzyme InhibitorsPhase 3711
28
MilrinoneapprovedPhase 1, Phase 23478415-72-24197
Synonyms:
-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4&prime
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
111GE027
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
78415-72-2
AB00514027
AC-4730
AC1L1HMP
AC1Q2EBX
BIDD:GT0197
BPBio1_001156
BRN 3546821
BSPBio_001050
C07224
C12H9N3O
CAS-78415-72-2
CCRIS 3795
CHEBI:50693
CHEMBL189
CID4197
CPD000058475
Corotrop
Corotrope
D00417
DB00235
EINECS 278-903-6
EN002063
EU-0100737
HMS1571E12
HMS2051L10
HMS2090J14
I06-0259
LS-44610
Lopac-M-4659
Lopac0_000737
 
M 4659
M1663
M4659_SIGMA
MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER
MLS000028818
MLS001424052
Milrila
Milrila (TN)
Milrinona
Milrinona [Spanish]
Milrinone
Milrinone (JAN/USAN/INN)
Milrinone Lactate
Milrinone [USAN:BAN:INN]
Milrinonum
Milrinonum [Latin]
NCGC00015675-01
NCGC00015675-02
NCGC00015675-04
NCGC00015675-07
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00164390-01
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Primacor
S2484_Selleck
SAM001246611
SBB055743
SMR000058475
SPBio_002965
Tocris-1504
UNII-JU9YAX04C7
WIN 47203-2
Win-47203
Win-47203-2
YM 018
ZINC09224016
milrinone
29
Ketamineapproved, vet_approvedPhase 25286740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
DEA No. 7285
 
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
Special k
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine
30Sildenafil CitratePhase 1, Phase 2323171599-83-0
31Platelet Aggregation InhibitorsPhase 1, Phase 22419
32Protective AgentsPhase 1, Phase 27190
33DextransPhase 299
34Pharmaceutical SolutionsPhase 27793
35Plasma SubstitutesPhase 2233
36Phosphodiesterase InhibitorsPhase 1, Phase 21254
37Blood SubstitutesPhase 2246
38AnticoagulantsPhase 22516
39Vasodilator AgentsPhase 1, Phase 23438
40Phosphodiesterase 5 InhibitorsPhase 1, Phase 2571
41Anesthetics, GeneralPhase 22787
42AnestheticsPhase 29001
43Phosphodiesterase 3 InhibitorsPhase 1, Phase 2131
44Anesthetics, IntravenousPhase 22406
45Anesthetics, DissociativePhase 2507
46Excitatory Amino Acid AntagonistsPhase 21282
47Excitatory Amino AcidsPhase 21297
48CitrateNutraceuticalPhase 1, Phase 21106
49
Citric Acidnutraceutical, vet_approvedPhase 1, Phase 2110677-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
50
Nitric OxideapprovedPhase 159910102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique

Interventional clinical trials:

(show top 50)    (show all 54)
idNameStatusNCT IDPhase
1The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.Not yet recruitingNCT02914652Phase 4
2Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
3Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.CompletedNCT01218607Phase 3
4The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart DiseaseCompletedNCT00480740Phase 3
5Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal DefectRecruitingNCT02644330Phase 2, Phase 3
6Safety and Effectiveness of the Nit-Occlud® Lê VSD Spiral Coil SystemSuspendedNCT00390702Phase 2, Phase 3
7Angiotensin Converting Enzyme Inhibition in Children With Mitral RegurgitationTerminatedNCT00113698Phase 3
8Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised ProtocolCompletedNCT01120964Phase 1, Phase 2
9Use of Ketamine Prior to Cardiopulmonary Bypass in ChildrenCompletedNCT00556361Phase 2
10Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary HypertensionCompletedNCT02595541Phase 1, Phase 2
11Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
12Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular SeptumCompletedNCT01609738Phase 1, Phase 2
13Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood FlowUnknown statusNCT01825369Phase 1
14Closure of Muscular Ventricular Septal Defects With The AMPLATZER® Muscular VSD OccluderUnknown statusNCT00583791Phase 1
15Closure of Perimembranous Ventricular Septal Defects With The AMPLATZER® Membranous VSD OCCLUDERCompletedNCT00578708Phase 1
16A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
17Radiation-Free Heart Catheterization Using MRIRecruitingNCT02739087Phase 1
18Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic AccessEnrolling by invitationNCT02280824Phase 1
19Study of Energy Expenditure in Infants With Ventricular Septal DefectsUnknown statusNCT00006272
20Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal DefectUnknown statusNCT00173186
21Acetaminophen for Oxidative Stress After Cardiopulmonary BypassUnknown statusNCT01228305
22Pivotal Study of a Percutaneous Mitral Valve Repair SystemUnknown statusNCT00209274
23Emergency/Compassionate Use - Muscular VSD OccluderApproved for marketingNCT00590382
24Transcatheter Closure Versus Surgery of Perimembranous Ventricular Septal DefectsCompletedNCT00890799
25Right Bundle Branch Block After Surgical Closure of Ventricular Septal DefectCompletedNCT01480908
26Longterm Outcome After Ventricular Septal Defect ClosureCompletedNCT02138435
27Hybrid Closure of Congenital Heart DiseaseCompletedNCT02794584
28A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
29The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary HypertensionCompletedNCT01313832
30Molecular Genetic Epidemiology of Three Cardiac Defects -SCOR in Pediatric Cardiovascular DiseaseCompletedNCT00005546
31Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular DiseaseCompletedNCT00005322
32Evaluation of Latent Pulmonary Arterial Hypertension in Congenital Shunt LesionsCompletedNCT02552485
33Measures to Lower the Stress Response in Pediatric Cardiac SurgeryCompletedNCT00848393
34Bupropion & Cardio Birth Defect (Slone)CompletedNCT01597661
35Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
36Quality of Life in Young Adults With Congenital Heart DiseaseCompletedNCT02463292
37Follow up of Post-repair Tetralogy of FallotCompletedNCT00266188
38Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patients With Shunt or Chronic Obstructive Pulmonary DiseaseCompletedNCT02449083
39Genes Causing Ebstein's AnomalyCompletedNCT00497705
40Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle PhysiologyCompletedNCT01563757
41EVEREST II Pivotal Study High Risk Registry (HRR)CompletedNCT01940120
42Evaluation of Dynamic Pulmonary Vascular Resistance in Patients With Closed Ventricular Septal DefectRecruitingNCT02648984
43Choice of Palliative Procedures for Pulmonary Atresia With Ventricular Septal Defect PatientsRecruitingNCT02861963
44Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder - Post Approval StudyRecruitingNCT00647387
45MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect ClosureRecruitingNCT03024268
46ADVANCE ASO AMPLATZER™ Atrial Septal Occluder Post Market Surveillance StudyRecruitingNCT02353351
47Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract ReconstructionActive, not recruitingNCT02700100
48AVJ-514 Japan TrialActive, not recruitingNCT02520310
49Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility StudyNot yet recruitingNCT03022708
50Emergency/Compassionate Use - Membranous VSD OccluderNo longer availableNCT00583505

Search NIH Clinical Center for Ventricular Septal Defect


Cochrane evidence based reviews: heart septal defects, ventricular

Genetic Tests for Ventricular Septal Defect

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Genetic tests related to Ventricular Septal Defect:

id Genetic test Affiliating Genes
1 Ventricular Septal Defect26

Anatomical Context for Ventricular Septal Defect

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MalaCards organs/tissues related to Ventricular Septal Defect:

35
Heart, Lung, Liver, Brain, Pineal, Colon

Animal Models for Ventricular Septal Defect or affiliated genes

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MGI Mouse Phenotypes related to Ventricular Septal Defect:

40 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7GATA4, GATA6, GDF1, JAG1, NFATC1, NODAL
2MP:00053798.6CITED2, GATA4, GATA5, GDF1, ISL1, JAG1
3MP:00107718.4GATA4, GATA5, ISL1, JAG1, NFATC1, NKX2-5
4MP:00053718.4CITED2, GATA4, GATA6, ISL1, NFATC1, TBX5
5MP:00053888.2CITED2, GATA4, GATA6, GDF1, NFATC1, NKX2-5
6MP:00030128.0GATA4, ISL1, JAG1, MYH7, NFATC1, NKX2-5
7MP:00053827.9CITED2, GDF1, ISL1, JAG1, NFATC1, NKX2-5
8MP:00028737.8CITED2, GATA4, GATA6, GDF1, ISL1, JAG1
9MP:00053817.4CITED2, GATA4, GATA5, GDF1, ISL1, JAG1
10MP:00053907.4CITED2, GATA4, GATA5, GDF1, ISL1, JAG1
11MP:00053767.0CITED2, GATA4, GATA5, GATA6, ISL1, JAG1
12MP:00053806.7BCOR, CITED2, GATA4, GATA6, GDF1, ISL1
13MP:00053696.7GATA4, GATA5, GATA6, ISL1, JAG1, MYH7
14MP:00053846.6CITED2, GATA4, GATA5, GATA6, GDF1, ISL1
15MP:00053786.4BCOR, CITED2, GATA4, GATA6, GDF1, ISL1
16MP:00107685.8BCOR, CITED2, GATA4, GATA5, GATA6, GDF1
17MP:00053855.2BCOR, CITED2, GATA4, GATA5, GATA6, GDF1

Publications for Ventricular Septal Defect

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Articles related to Ventricular Septal Defect:

(show top 49)    (show all 1054)
idTitleAuthorsYear
1
Transcatheter device closure of postmyocardial infarction ventricular septal defect. (27889458)
2017
2
Perventricular device closure of perimembranous ventricular septal defect: effectiveness of symmetric and asymmetric occluders. (28082474)
2017
3
Incidental Ventricular Septal Defect (VSD) in the Donor of a Live Donor Liver Transplant: Tackle and Proceed. (27790513)
2016
4
Predictors for the Outcome of Aortic Regurgitation After Cardiac Surgery in Patients with Ventricular Septal Defect and Aortic Cusp Prolapse in Saudi Patients. (27867454)
2016
5
Systolic murmur in a young man who had previous ventricular septal defect repair: The double-chambered right ventricle. (26432742)
2015
6
A case of Gerbode-type ventricular septal defect and mitral anterior valve cleft with severe regurgitation. (26363755)
2015
7
Single Cusp Replacement in Patients with Ventricular Septal Defect and Aortic Insufficiency. (25872409)
2015
8
Hybrid Stage I Palliation in a 1.1 kg, 28-Week Preterm Neonate With Posterior Malalignment Ventricular Septal Defect, Left Ventricular Outflow Tract Obstruction, and Coarctation of the Aorta. (25324263)
2014
9
Demonstration of doubly committed juxta-arterial ventricular septal defect with aortic valve prolapse by cardiac computed tomography. (24582047)
2014
10
Concomitant surgical repair of a perimembranous ventricular septal defect and mitral regurgitation in an adult. (25231419)
2014
11
Muscular ventricular septal defect in a newborn with truncus arteriosus communis: perventricular transcatheter closure under echocardiographic guidance only, a case report. (25324260)
2014
12
Unusual association of aortic valve stenosis with ventricular septal defect and pulmonary atresia: Differentiation from truncus arteriosus with truncal valve stenosis. (23626446)
2013
13
Outcome and requirement for surgical repair following prenatal diagnosis of ventricular septal defect. (24357326)
2013
14
Double-Patch Repair by a Bilateral Ventriculotomy for Postinfarction Ventricular Septal Defect. (24298992)
2013
15
Constrictive pericarditis developed after childhood repair of ventricular septal defect. (23910801)
2013
16
Prevalence of anomalous coronary arteries in pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals. (23871887)
2013
17
Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects. (22465533)
2012
18
Early migration of an Amplatzer muscular ventricular septal defect occluder device causing severe tricuspid valve obstruction. (22089813)
2012
19
Stroke complicating traumatic ventricular septal defect. (21620609)
2012
20
Double orifice mitral valve associated with Ventricular Septal Defect in an infant: Case Report. (22368568)
2011
21
Ventricular septal defect with aortic valve insufficiency in a New Zealand White rabbit. (21730092)
2011
22
Inferior vena cava and renal vein thrombosis in a patient with ventricular septal defect. (21533861)
2011
23
Hepatic and renal failure after anterior myocardial infarction induced apical ventricular septal defect. (21274286)
2010
24
Right ventricular remodeling in restrictive ventricular septal defect. (20637777)
2010
25
Subcutaneous fat necrosis of the newborn associated with ventricular septal defect and patent ductus arteriosus. (19702998)
2009
26
Ventricular septal diverticule and ventricular septal defect after penetrating cardiac trauma. (19196578)
2009
27
Gerbode ventricular septal defect diagnosed at cardiac MR imaging: case report. (19561249)
2009
28
A left ventricular-to-right atrial shunt in a patient with a perimembranous ventricular septal defect: role of intraoperative transesophageal echocardiography. (19217800)
2009
29
Survival into sixth decade of untreated pulmonary atresia with ventricular septal defect and major aorto-pulmonary collaterals: a magnetic resonance imaging study. (19359994)
2009
30
Gasless laparoscopic surgery for ovarian cyst in a second trimester pregnant patient with a ventricular septal defect. (18097327)
2007
31
Right aortic coarctation and ventricular septal defect: an unusual cause of tracheal compression in infancy. (18377543)
2006
32
Construction of a pulmonary artery pump for unifocalization and repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals. (15918448)
2005
33
Arterial switch operation for transposition of the great arteries combined with closure of paramembranous ventricular septal defect using the Amplatzer membranous ventricular septal occluder. (16098318)
2005
34
Vertebral malformation, syringomyelia, and ventricular septal defect in a dromedary camel (Camelius dromedarius). (15305748)
2004
35
Clinical implication of plasma natriuretic peptides in children with ventricular septal defect. (12828576)
2003
36
Apico-pulmonary artery conduit repair of congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary outflow tract obstruction: a 10-year follow-up. (14602256)
2003
37
A case with dextrocardia, ventricular septal defect, persistent left superior vena cava and drainage of the great cardiac vein into the left internal thoracic vein. (11490934)
2001
38
Pulmonary atresia with ventricular septal defect and persistent airway hyperresponsiveness. (11436051)
2001
39
Classification of pulmonary atresia with ventricular septal defect. (11465219)
2001
40
Ruptured aneurysm of sinus of valsalva with ventricular septal defect: the role of transesophageal echocardiography in diagnosis. (10912442)
2000
41
Transposition of the great arteries, pulmonary atresia, and multiple ventricular septal defects associated with multiple cardiac rhabdomyomas in a case of tuberous sclerosis. (10754091)
2000
42
Branch pulmonary artery growth after blalock-taussig shunts in tetralogy of fallot and pulmonary atresia with ventricular septal defect: a retrospective, echocardiographic study. (10441692)
1999
43
Aortic coarctation, multiple ventricular septal defects, and anomalous coronary artery arising from the right pulmonary artery. (9451072)
1998
44
Pulmonary atresia with ventricular septal defect: a case for central venous pressure and oxygen saturation monitoring. (9713951)
1998
45
Total repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals: an integrated approach. (9832681)
1998
46
Images in cardiovascular medicine. Huge dilatation of pulmonary arteries due To ventricular septal defect with the Eisenmenger syndrome. (8941151)
1996
47
Left ventricular outflow tract obstruction with aortic arch anomalies and ventricular septal defect. (2241361)
1990
48
Double outlet right ventricle with severe left ventricular outflow tract obstruction due to small ventricular septal defect and anomalous adherence of the mitral valve to the ventricular septum. (3437510)
1987
49
Surgical treatment of congenital pulmonary atresia with ventricular septal defect. (5540464)
1971

Variations for Ventricular Septal Defect

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Clinvar genetic disease variations for Ventricular Septal Defect:

5
id Gene Variation Type Significance SNP ID Assembly Location
146;XY;t(5;7)(q35;q33)dnTranslocationPathogenicChr na, -1: -1

Expression for genes affiliated with Ventricular Septal Defect

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Search GEO for disease gene expression data for Ventricular Septal Defect.

Pathways for genes affiliated with Ventricular Septal Defect

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GO Terms for genes affiliated with Ventricular Septal Defect

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Cellular components related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056345.5BCOR, CITED2, GATA4, GATA5, GATA6, HOMEZ

Biological processes related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:005501410.8NKX2-5, NKX2-6
2bundle of His developmentGO:000316610.8NKX2-5, TBX5
3transdifferentiationGO:006029010.7GATA4, TBX5
4ventricular cardiac muscle cell developmentGO:005501510.7NKX2-5, NKX2-6
5pericardium developmentGO:006003910.6NKX2-6, TBX5
6right ventricular cardiac muscle tissue morphogenesisGO:000322110.6NKX2-5, ZFPM2
7embryonic heart tube left/right pattern formationGO:006097110.6CITED2, NKX2-5
8pulmonary artery morphogenesisGO:006115610.5CITED2, JAG1
9embryonic process involved in female pregnancyGO:006013610.4CITED2, NODAL
10nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryGO:190016410.4CITED2, NODAL
11positive regulation of cell-cell adhesionGO:002240910.4CITED2, NODAL
12cardiac ventricle morphogenesisGO:000320810.4GATA4, NKX2-5
13trophectodermal cell differentiationGO:000182910.4CITED2, NODAL
14cardiac muscle hypertrophy in response to stressGO:001489810.4GATA6, MYH7
15cardiac neural crest cell development involved in outflow tract morphogenesisGO:006130910.4JAG1, TWIST1
16adult heart developmentGO:000751210.4MYH7, NKX2-5
17cardiac septum morphogenesisGO:006041110.4CITED2, JAG1
18positive regulation of cardiac muscle cell proliferationGO:006004510.3GATA6, TBX5, ZFPM2
19positive regulation of cardioblast differentiationGO:005189110.3GATA4, GATA6, NKX2-5, TBX5
20endocardial cushion developmentGO:000319710.3CITED2, GATA4, TBX5
21cardiac muscle tissue developmentGO:004873810.3GATA6, NKX2-5, ZFPM2
22intestinal epithelial cell differentiationGO:006057510.3GATA4, GATA5, GATA6
23positive regulation of male gonad developmentGO:200002010.3CITED2, ZFPM2
24pharyngeal system developmentGO:006003710.3ISL1, NKX2-5, NKX2-6
25ventricular septum morphogenesisGO:006041210.3CITED2, NKX2-5, ZFPM2
26cardiac muscle cell differentiationGO:005500710.3GATA4, GATA6, NKX2-5, TBX5
27cardiac right ventricle morphogenesisGO:000321510.2GATA4, ISL1, JAG1
28embryonic heart tube developmentGO:003505010.2NKX2-5, NKX2-6, NODAL
29vasculogenesisGO:000157010.2CITED2, NKX2-5, ZFPM2
30BMP signaling pathwayGO:003050910.1GDF1, NKX2-5, NODAL
31ventricular septum developmentGO:000328110.1CITED2, GATA4, TBX5
32outflow tract morphogenesisGO:000315110.0CITED2, ISL1, NKX2-5
33outflow tract septum morphogenesisGO:000314810.0GATA6, ISL1, NKX2-5, ZFPM2
34anatomical structure formation involved in morphogenesisGO:004864610.0GATA4, GATA5, NODAL
35positive regulation of vascular endothelial growth factor productionGO:001057510.0GATA4, ISL1, NODAL
36cell fate commitmentGO:004516510.0GATA4, GATA5, GATA6, NODAL
37atrial septum morphogenesisGO:006041310.0GATA4, ISL1, NKX2-5, TBX5
38cell developmentGO:00484689.9GATA4, GATA5, GATA6, GDF1
39heart loopingGO:00019479.8CITED2, GATA4, NKX2-5, NODAL
40negative regulation of cell differentiationGO:00455969.7JAG1, NODAL, TWIST1
41blood coagulationGO:00075969.7GATA4, GATA5, GATA6, ZFPM2
42in utero embryonic developmentGO:00017019.3CITED2, GATA6, NODAL, TWIST1, ZFPM2
43negative regulation of apoptotic processGO:00430669.3CITED2, GATA6, NKX2-5, NKX2-6, TWIST1
44positive regulation of angiogenesisGO:00457669.2GATA4, GATA6, ISL1, NODAL, TWIST1
45transcription from RNA polymerase II promoterGO:00063668.9GATA4, GATA5, GATA6, ISL1, NFATC1, NKX2-5
46negative regulation of transcription, DNA-templatedGO:00458928.5BCOR, CITED2, GATA6, NKX2-5, TWIST1, ZFPM2
47positive regulation of transcription, DNA-templatedGO:00458938.4CITED2, GATA4, GATA5, GATA6, NFATC1, NKX2-5
48heart developmentGO:00075077.8BCOR, CITED2, GATA5, ISL1, NKX2-5, NKX2-6
49negative regulation of transcription from RNA polymerase II promoterGO:00001226.6BCOR, CITED2, GATA6, HOMEZ, ISL1, NKX2-5
50positive regulation of transcription from RNA polymerase II promoterGO:00459446.4CITED2, GATA4, GATA5, GATA6, ISL1, JAG1

Molecular functions related to Ventricular Septal Defect according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:004342510.2ISL1, TWIST1
2enhancer sequence-specific DNA bindingGO:000115810.2GATA4, GATA5, ISL1
3RNA polymerase II transcription coactivator activityGO:000110510.0CITED2, ISL1, ZFPM2
4transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.7GATA4, GATA5, GATA6, NKX2-5, TBX5
5transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037059.7GATA5, GATA6, NFATC1, NKX2-5
6transcription regulatory region DNA bindingGO:00442129.4BCOR, GATA4, GATA5, GATA6, NKX2-5
7RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009779.2GATA4, GATA5, GATA6, NFATC1, TBX5
8RNA polymerase II transcription factor bindingGO:00010859.2GATA4, GATA5, GATA6, NFATC1, ZFPM2
9sequence-specific DNA bindingGO:00435659.0GATA4, GATA6, ISL1, NKX2-5, NKX2-6, TBX5
10chromatin bindingGO:00036828.7CITED2, GATA4, GATA5, GATA6, ISL1, NKX2-5
11transcription factor bindingGO:00081348.5BCOR, GATA4, GATA6, NKX2-5, TBX5, TWIST1
12transcription corepressor activityGO:00037148.3BCOR, CITED2, HOMEZ, ZFPM2
13DNA bindingGO:00036777.7GATA4, GATA5, GATA6, HOMEZ, ISL1, NKX2-5
14transcription factor activity, sequence-specific DNA bindingGO:00037007.0CITED2, GATA4, GATA5, GATA6, HOMEZ, NFATC1

Sources for Ventricular Septal Defect

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet