Ventricular Tachycardia malady

MalaCards: Ventricular Tachycardia, also known as tachycardia, ventricular, is related to catecholaminergic polymorphic ventricular tachycardia and brugada syndrome. An important gene associated with Ventricular Tachycardia is CASQ2 (calsequestrin 2 (cardiac muscle)), and among its related pathways are Beta-Adrenergic Signaling and Potassium transporters- outward current. The drugs epinephrine hydrochloride and metoprolol and the compounds glucose and 4-chloro-m-cresol have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

ventricular tachycardia 7 tachycardia, ventricular 43

Diseases related to ventricular tachycardia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 193)

id	Related Disease	Score	Top Affiliating Genes
1	catecholaminergic polymorphic ventricular tachycardia	37.5	KCNH2, SCN5A, NPPB
2	brugada syndrome	31.4	KCNH2, KCNJ2, KCNE2, SCN5A, ANK2, RYR2
3	sick sinus syndrome	30.4	SCN5A, ANK2, NPPA, NPPB
4	long qt syndrome	28.8	KCNH2, KCNJ2, KCNE2, SCN5A, FKBP1B, ANK2
5	heart block	28.7	LMNA, KCNE2, SCN5A, CALR, ACE2, NPPA
6	sudden cardiac death multi-gene panels	27.7	LMNA, KCNH2, KCNJ2, KCNE2, SCN5A, FKBP1B
7	sinusitis	26.7	KCNH2, SCN5A, ANK2, CAMP, GJA1, ACE
8	acute myocardial infarction	26.5	SCN5A, CHKB, HTR3A, ABCC9, ACE, TIMP1
9	syncope	26.0	KCNH2, KCNJ2, KCNE2, SCN5A, CHKB, ANK2
10	twinning	25.9	LMNA, KCNH2, KCNE2, SCN5A, CASQ2, ACE
11	myocardial infarction	25.1	KCNE2, SCN5A, CHKB, INTS8, ANK2, HTR3A
12	familial atrial fibrillation	13.5	KCNE2, SCN5A
13	sinus bradycardia syndrome	13.5	KCNH2, ANK2
14	long qt syndrome 2	13.5	KCNH2, SCN5A
15	gas gangrene	13.5	CHKB, CASQ1, CASQ2
16	malignant hyperthermia susceptibility	13.5	ASPH, CALR, RYR1, RYR2
17	hypokalemic periodic paralysis	13.5	KCNJ2, CHKB, RYR1
18	muscle disorders	13.5	CHKB, RYR1, RYR2
19	short qt syndrome	13.4	KCNH2, KCNJ2
20	ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence	13.4	NPPB, RYR2
21	long qt syndrome 1	13.4	KCNH2, KCNE2, SCN5A
22	rhabdomyolysis, cerivastatin-induced	13.4	CHKB, ACADVL, RYR1
23	jervell-lange nielsen syndrome	13.4	KCNH2, KCNE2, SCN5A
24	left ventricular noncompaction	13.3	LMNA, SCN5A, FKBP1B, RYR2
25	resting heart rate	13.2	SCN5A, CASQ1, GJA1, ADRB1
26	central core myopathy	13.2	RYR1, RYR2, RYR3
27	congenital heart block	13.2	LMNA, KCNE2, SCN5A, CALR
28	myopathy congenital	13.2	LMNA, CHKB, RYR1
29	nephrosclerosis	13.2	ACE, ACE2, ADRB1
30	central sleep apnea	13.1	NPPA, NPPB
31	posterior urethral valves	13.1	ACE, ACE2
32	alpha 1-antitrypsin deficiency	13.1	KCNH2, SCN5A, CHKB, SLC25A20, RYR2
33	sexual disorder	13.0	OXT, PRL
34	cardiac rupture	13.0	CHKB, NPPB
35	fainting	13.0	KCNH2, SCN5A, CHKB, GNAI2, ADRB1
36	high blood pressure	13.0	GNAI2, ACE, NPPB
37	heart valve disease	12.9	HTR3A, NPPA, NPPB
38	familial hypertrophic cardiomyopathy	12.9	FKBP1B, CALR, CASQ2, ACE, NPPB
39	familial dilated cardiomyopathy	12.9	LMNA, GJA1, TRDN
40	phobia	12.9	HTR3A, OXT, PRL
41	mitral valve insufficiency	12.9	ACE, NPPA, NPPB
42	abcb11-related intrahepatic cholestasis	12.9	OXT, NPPA, NPPB
43	oligohydramnios	12.9	ACE, OXT, NPPB
44	petrositis	12.9	OXT, PRL, NPPA
45	diastolic heart failure	12.9	ACE, NPPA, NPPB
46	cocaine abuse	12.8	CHKB, INTS8, HTR3A, PRL
47	conduction disease	12.8	LMNA, SCN5A, TIMP1
48	systolic heart failure	12.8	ACE, NPPA, NPPB
49	renovascular hypertension	12.8	ACE, NPPA, NPPB
50	cor pulmonale	12.8	ACE, NPPA, NPPB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acebutolol, acebutolol hydrochloride, atenolol, bretylium, bretylium tosylate, edta, edta tetrasodium, epinephrine, epinephrine bitartrate, epinephrine hydrochloride, epinephrine,racemic hydrochloride, epinephryl borate, esmolol, esmolol hydrochloride, flecainide, flecainide acetate, lidocaine, lidocaine hcl pwdr [va product], lidocaine hydrochloride, lidocaine pwdr [va product], metoprolol, metoprolol succinate, metoprolol tartrate, moricizine, moricizine hydrochloride, procainamide, procainamide hydrochloride, propranolol, propranolol hydrochloride, sotalol, sotalol hydrochloride, vasopressin, vasopressin tannate (in oil)

MalaCards organs/tissues related to ventricular tachycardia:

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MGI Mouse Phenotypes related to ventricular tachycardia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	FKBP1B, GJA1, GNAI2
2	mortality/aging	MP:0010768	5.3	ACE, ACADVL, ACE2, TIMP1, OXT, RYR1
3	cardiovascular system phenotype	MP:0005385	4.0	ADRB1, ADCY10, RYR2, RYR1, OXT, AKAP10
4	homeostasis/metabolism phenotype	MP:0005376	3.6	ACADVL, ACE2, TIMP1, OXT, PRL, NPPA
5	muscle phenotype	MP:0005369	INF	RYR3, FKBP1B, ASPH, SCN5A, KCNJ2, KCNH2
6	growth/size phenotype	MP:0005378	INF	CALR, CASQ1, GNAI2, HTR3A, ANK2, SCN5A
7	behavior/neurological phenotype	MP:0005386	INF	OXT, PRL, RYR1, RYR2, RYR3, ACADVL

Articles related to ventricular tachycardia:

(show top 50)    (show all 87)

id	Title	Authors	Year	Affiliating Genes
1	Postpacing abnormal repolarization in catecholaminerg ic polymorphic ventricular tachycardia associated with a mutation in the cardia c ryanodine receptor gene. (21699856)	Nof E.... Glikson M.	2011	RYR1
2	Biophysical and molecular characterization of a novel de novo KCNJ2 mutation associated with Andersen-Tawil syndrome and catecholami nergic polymorphic ventricular tachycardia mimicry. (21148745)	Barajas-Martinez H.... Antzelevitch C.	2011	KCNJ2
3	Inhibition of cardiac Ca2+ release channels (RyR2) de termines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorp hic ventricular tachycardia. (21270101)	Hwang H.S.... Knollmann B.C.	2011	RYR2
4	Arrhythmia characterization and long-term outcomes in catecholaminergic polymorphic ventricular tachycardia. (21315846)	Sy R.W.... Krahn A.D.	2011	RYR2
5	Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanod ine receptor. (20224043)	Uchinoumi H.... Matsuzaki M.	2010	RYR2
6	Sick sinus syndrome, progressive cardiac conduction d isease, atrial flutter and ventricular tachycardia caused by a novel SCN5A muta tion. (20395683)	Holst A.G.... Tfelt-Hansen J.	2010	SCN5A
7	High prevalence of exercise-induced arrhythmias in ca techolaminergic polymorphic ventricular tachycardia mutation-positive family me mbers diagnosed by cascade genetic screening. (20106799)	Haugaa K.H.... Amlie J.P.	2010	RYR2
8	Molecular basis of catecholaminergic polymorphic ventricular tachycardia. (19121813)	GyAPrke S.	2009	RYR2, CASQ2
9	Incidence and risk factors of arrhythmic events in ca techolaminergic polymorphic ventricular tachycardia. (19398665)	Hayashi M.... Leenhardt A.	2009	RYR2, CASQ2
10	Genetic of catecholaminergic polymorphic ventricular tachycardia: basic concepts (20361477)	Medeiros-Domingo A.	2009	CASQ2
11	Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A. (19279983)	Tfelt-Hansen J.... Haunso S.	2009	SCN5A
12	The RYR2-encoded ryanodine receptor/calcium release c hannel in patients diagnosed previously with either catecholaminergic polymorph ic ventricular tachycardia or genotype negative, exercise-induced long QT syndr ome: a comprehensive open reading frame mutational analysis. (19926015)	Medeiros-Domingo A.... Ackerman M.J.	2009	RYR2
13	A Novel mutation of F189L in CASQ2 in families with catecholaminergic polymorphic ventricular tachycardia. (18543230)	Liu Q.... Wang Q.K.	2008	CASQ2
14	Catecholaminergic polymorphic ventricular tachycardia in a child: a case report. (18052993)	Garabedian L.... De Wolf D.	2008	RYR2, CASQ2
15	Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (17987279)	Geiger S.K.... Weichenhan D.	2008	LMNA
16	Catecholaminergic polymorphic ventricular tachycardia-related mutations R33Q and L167H alter calcium sensitivity of human cardiac calsequestrin. (18399795)	Valle G.... Volpe P.	2008	CASQ2
17	U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers. (18929323)	Viitasalo M.... Swan H.	2008	RYR2
18	A novel early onset lethal form of catecholaminergic polymorphic ventricular tachycardia maps to chromosome 7p14-p22. (17666061)	Bhuiyan Z.A.... Al-Gazali L.	2007	RYR2, FKBP1B
19	Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction. (17526509)	Blangy H.... Zannad F.	2007	TIMP1, NPPB
20	A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia. (17897635)	Tan B.H.... Makielski J.C.	2007	SCN5A
21	Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia. (17234962)	Iyer V.... Armoundas A.A.	2007	RYR2
22	Calsequestrin mutation and catecholaminergic polymorphic ventricular tachycardia: a simulation study of cellular mechanism. (17531962)	Faber G.M.... Rudy Y.	2007	CASQ2
23	Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. (17607358)	Song L.... Seidman J.G.	2007	CALR, RYR2, CASQ2
24	A novel SCN5A deletion mutation in a child with ventricular tachycardia, recurrent aborted sudden death, and Brugada electrocardiographic pattern. (18361072)	MA!rquez M.F.... Vargas-AlarcA^n G.	2007	SCN5A
25	Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. (17209005)	Werdich A.A.... Exil V.J.	2007	ACADVL
26	Unraveling the mechanisms of catecholaminergic polymorphic ventricular tachycardia. (17959506)	Iyer V.... Armoundas A.A.	2006	RYR2
27	Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. (16825580)	Liu N.... Priori S.G.	2006	RYR2
28	Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. (16239587)	Jiang D.... Chen S.R.	2005	RYR2
29	Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia. (15911700)	Nam G.B.... Antzelevitch C.	2005	RYR2
30	Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations. (15720454)	Swan H.... Toivonen L.	2005	RYR2
31	A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia. (15749201)	Aizawa Y.... Aizawa Y.	2005	RYR2, FKBP1B
32	RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). (15322274)	Jiang D.... Chen S.R.	2004	RYR2
33	A missense mutation in CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. (15176429)	Lahat H.... Eldar M.	2004	CASQ2
34	Polymorphic ventricular tachycardia and KCNJ2 mutations. (15851159)	Chun T.U.... Benson D.W.	2004	KCNJ2
35	A missense mutation in the CASQ2 gene is associated with autosomal-recessive catecholamine-induced polymorphic ventricular tachycardia. (12732448)	Eldar M.... Lahat H.	2003	CASQ2
36	Diagnosis of adrenergic ventricular tachycardia in two homozygotic twins (12838845)	Dulac Y.... Delay M.	2003	CASQ2
37	Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. (12967627)	Donoghue M.... Breitbart R.E.	2003	ACE2
38	Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. (12919952)	George C.H.... Lai F.A.	2003	RYR1, RYR2, ADCY10
39	Autosomal recessive catecholamine-induced polymorphic ventricular tachycardia. (19649236)	Lahat H.... Eldar M.	2002	CASQ2
40	Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy. (12197595)	Iwai C.... Yokoyama M.	2002	ADRB1
41	A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. (12858557)	Eldar M.... Lahat H.	2002	CASQ2
42	Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia. (12386154)	Postma A.V.... Guicheney P.	2002	CASQ2
43	Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism. (12507404)	Scaglia F.... Wong L.J.	2002	SLC25A20
44	Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia. (11807805)	Marks A.R.... Laitinen P.J.	2002	RYR2
45	Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. (11972032)	Papadatos G.A.... Grace A.A.	2002	SCN5A
46	A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. (11704930)	Lahat H.... Eldar M.	2001	CASQ2
47	A case report of myolysis during high-dose amiodarone therapy for uncontrolled ventricular tachycardia. (9583467)	Itoh K.... Hotta N.	1998	CHKB
48	Hemodynamic recovery, atrial natriuretic peptide, and catecholamines during simulated ventricular tachycardia: effects of ventriculoatrial conduction. (7700835)	Peuhkurinen K.J.... Huikuri H.	1995	NPPA
49	Determinants of induction of ventricular tachycardia in nonsustained ventricular tachycardia after myocardial infarction and the use fulness of the signal-averaged electrocardiogram. (8256704)	Winters S.L.... Gomes J.A.	1993	INTS8
50	Comparative electrophysiological effects of captopril or hydralazine combined with nitrate in patients with left ventricular dysfunc tion and inducible ventricular tachycardia. (1389714)	Bashir Y.... Camm A.J.	1992	ACE

Genes related to ventricular tachycardia according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	CASQ2	calsequestrin 2 (cardiac muscle)	11.1	Publications, Summaries, Orthologs
2	RYR2	ryanodine receptor 2 (cardiac)	11.1	Publications, Orthologs, Summaries
3	CPVT3	Ventricular tachycardia, catecholaminergic polymorphic, 3	11.1	Aliases & Descriptions
4	TMEM43	transmembrane protein 43	11.0	Summaries
5	FKBP1B	FK506 binding protein 1B, 12.6 kDa	11.0	Publications
6	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	11.0	Publications
7	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	11.0
8	ANK2	ankyrin 2, neuronal	11.0	Publications
9	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
10	CALR	calreticulin	11.0	Publications
11	ASPH	aspartate beta-hydroxylase	11.0	Publications
12	RYR1	ryanodine receptor 1 (skeletal)	11.0	Publications, Orthologs
13	CASQ1	calsequestrin 1 (fast-twitch, skeletal muscle)	11.0	Orthologs
14	KCNIP2	Kv channel interacting protein 2	11.0	Publications
15	SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	11.0	Publications
16	KCNE2	potassium voltage-gated channel, Isk-related family, member 2	11.0	Publications
17	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
18	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.0	Publications
19	AKAP10	A kinase (PRKA) anchor protein 10	11.0
20	ADRB1	adrenoceptor beta 1	11.0	Publications
21	INTS8	integrator complex subunit 8	11.0	Publications
22	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	11.0
23	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications
24	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
25	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	11.0	Publications
26	CHKB	choline kinase beta	11.0	Publications
27	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
28	OXT	oxytocin, prepropeptide	11.0	Publications
29	LMNA	lamin A/C	11.0	Publications
30	RYR3	ryanodine receptor 3	11.0	Orthologs
31	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
32	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
33	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
34	NPPA	natriuretic peptide A	11.0	Publications
35	NPPB	natriuretic peptide B	11.0	Publications
36	PRL	prolactin	11.0	Publications
37	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications

Pathways related to ventricular tachycardia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Beta-Adrenergic Signaling36	9.7	RYR1, ADRB1, RYR3, RYR2, GNAI2
2	Potassium transporters- outward current10	9.6	KCNH2, KCNJ2, GJA1, ABCC9
3	PKA Signaling36	9.1	RYR2, RYR1, AKAP10, GNAI2, SCN5A, RYR3
4	Intracellular Calcium Signaling36	9.0	HTR3A, RYR3, RYR2, RYR1, TIMP1, GNAI2
5	Activation of cAMP-Dependent PKA36	8.9	ADRB1, RYR3, SCN5A, GNAI2, AKAP10, TIMP1
6	Activation of PKA through GPCR36	8.8	AKAP10, GNAI2, ADRB1, TIMP1, RYR1, RYR2
7	cAMP Pathway36	8.8	ADRB1, SCN5A, RYR3, RYR2, RYR1, TIMP1
8	Antiarrhythmic Pathway, Pharmacodynamics34	8.1	FKBP1B, SCN5A, KCNE2, KCNJ2, KCNIP2, KCNH2

Compounds related to ventricular tachycardia according to GeneDecks:

(show top 50)    (show all 154)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.0	GJA1, RYR1, SLC25A20, CALR
2	4-chloro-m-cresol32	9.9	RYR2, RYR1, RYR3
3	halothane32 9 9	11.6	CHKB, KCNH2, CALR, GJA1, RYR1
4	xamoterol32	9.6	ADRB1, ADCY10, CHKB
5	salbutamol32 34 9 18 9	13.3	ADCY10, ADRB1, NPPA, CAMP, CHKB
6	inositol 1,4,5 trisphosphate32	9.3	ANK2, CALR, OXT, RYR1, RYR2, ADCY10
7	dobutamine32 9 9	11.2	NPPB, ADRB1, NPPA, CHKB
8	pindolol32 9 9	11.2	ADRB1, ADCY10, HTR3A, PRL
9	bisoprolol32 9 9	11.1	ADRB1, NPPB, NPPA, ACE
10	ipsapirone32	9.1	PRL, OXT, HTR3A, ADCY10
11	enalaprilat32	9.0	NPPB, ACE2, NPPA, ACE
12	phenytoin32 34 9 9	12.0	CHKB, KCNH2, SCN5A, TIMP1, ABCB1
13	verapamil32 34 9 18 9	12.9	ACE, ABCB1, GJA1, SCN5A, RYR2, KCNH2
14	celiprolol32	8.9	NPPB, ACE, ABCB1
15	atenolol32 9 18 9	11.9	NPPB, ACE, ADRB1, ABCB1, KCNH2
16	ramipril32 9 9	10.8	NPPB, NPPA, ACE2, ACE
17	alacepril32	8.8	NPPB, ACE, NPPA
18	buspirone32 9 9	10.8	ABCB1, HTR3A, ADCY10, PRL
19	risperidone32 34 9 18 9	12.7	PRL, CHKB, ADRB1, HTR3A, ABCB1
20	propranolol32 34 9 18 9	12.7	NPPA, ABCB1, ADRB1, ADCY10, HTR3A, KCNH2
21	isoproterenol32 9 9	10.7	KCNH2, KCNJ2, FKBP1B, CAMP, GJA1, RYR1
22	chlorpromazine32 9 9	10.7	ABCB1, HTR3A, CHKB, KCNH2, PRL
23	amiodarone32 9 9	10.6	ABCB1, KCNH2, CHKB, ACE, NPPB, ADRB1
24	candoxatril32 9 9	10.6	NPPB, NPPA, ACE
25	thapsigargin32 42	9.6	ADCY10, CALR, TIMP1, OXT, NPPB, RYR1
26	lisinopril32 9 18 9	11.6	ACE2, NPPB, ACE, ABCB1, NPPA
27	fluoxetine32 34 9 9	11.6	ABCB1, KCNH2, PRL, OXT, HTR3A
28	digoxin32 42 34 9 18 9	13.5	NPPB, ABCB1, NPPA, ACE, RYR1
29	spironolactone32 42 34 9 9	12.5	ABCB1, ACE, NPPA, NPPB, KCNH2
30	creatinine32	8.5	LMNA, RYR1, SLC25A20, ACE, ACADVL, OXT
31	olanzapine32 34 9 18 9	12.4	KCNH2, PRL, ABCB1, HTR3A, CHKB
32	captopril32 42 9 9	11.4	ACE2, NPPB, NPPA, ACE, ABCB1
33	metoprolol32 34 9 18 9	12.4	ADRB1, NPPB, NPPA, ABCB1, KCNH2, ACE
34	tacrolimus32 34 9 9	11.3	NPPB, RYR1, RYR3, RYR2, CHKB, TIMP1
35	nifedipine32 9 9	10.3	NPPA, RYR1, ABCB1, ACE, TIMP1, OXT
36	sodium32 18	8.9	KCNE2, KCNH2, SCN5A, ADRB1, RYR2, NPPB
37	carvedilol32 34 9 9	10.8	ACE, RYR2, RYR1, NPPB, ABCB1, GJA1
38	potassium32 9 18 9	10.8	RYR2, ADRB1, RYR1, KCNIP2, KCNJ2, KCNE2
39	haloperidol32 34 9 9	10.8	NPPA, KCNH2, HTR3A, PRL, ABCB1, NPPB
40	forskolin32 42 9 9	10.7	CAMP, NPPB, ADRB1, ADCY10, OXT, KCNH2
41	lipid32	7.5	RYR1, SLC25A20, NPPB, ACE, RYR3, ACADVL
42	epinephrine32 9 18 9	10.2	CHKB, ADRB1, ADCY10, RYR2, NPPB, NPPA
43	nitric oxide32 9 18 9	10.1	NPPA, CHKB, CAMP, RYR2, RYR1, ADRB1
44	dexamethasone32 42 34 9 9	10.7	ADCY10, ADRB1, ABCB1, NPPB, PRL, GJA1
45	norepinephrine32 9 18 9	9.5	NPPA, CHKB, HTR3A, ACE, ADCY10, TIMP1
46	arginine32	6.0	PRL, NPPA, NPPB, SLC25A20, RYR1, ADCY10
47	caffeine32 34 9 18 9	INF	RYR3, ABCB1, RYR2, FKBP1B, NPPA, RYR1
48	calcium32 9 18 9	INF	, LMNA, KCNIP2, NPPB, SCN5A, CHKB
49	dihydropyridine32	INF	CALR, , ACE, RYR1, ASPH
50	ryanodine32	INF	CALR, ANK2, FKBP1B, ASPH, CASQ2, GJA1

Cellular components related to ventricular tachycardia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	T-tubule	GO:030315	10.0	RYR1, ANK2, CASQ1, SCN5A
2	junctional membrane complex	GO:030314	10.0	RYR1, RYR3
3	intercalated disc	GO:014704	9.8	GJA1, ANK2, SCN5A
4	voltage-gated potassium channel complex	GO:008076	9.7	ABCC9, KCNE2, KCNIP2, KCNH2
5	sarcoplasmic reticulum membrane	GO:033017	9.6	RYR1, RYR2, RYR3
6	plasma membrane	GO:005886	INF	ACE, ACE2, RYR1, RYR2, ADCY10, ADRB1
7	junctional sarcoplasmic reticulum membrane	GO:014701	INF	RYR2, RYR1, , CASQ2, ASPH
8	sarcoplasmic reticulum	GO:016529	INF	RYR2, RYR1, CASQ2,
9	sarcoplasmic reticulum lumen	GO:033018	INF	, CALR, CASQ2

Biological processes related to ventricular tachycardia according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	Purkinje myocyte to ventricular cardiac muscle cell signaling	GO:086029	10.5	RYR2, CASQ2
2	sarcoplasmic reticulum calcium ion transport	GO:070296	10.5	RYR2, ANK2
3	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:014808	10.4	RYR1, FKBP1B, RYR2
4	regulation of ventricular cardiac muscle cell action potential	GO:086005	10.4	ANK2, SCN5A, RYR2
5	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	GO:010881	10.4	RYR2, ANK2, CASQ2, FKBP1B
6	SA node cardiomyocyte to atrial cardiomyocyte communication	GO:086070	10.4	SCN5A, ANK2
7	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:010880	10.3	CASQ2, ASPH
8	sequestering of calcium ion	GO:051208	10.2	CALR, CASQ2
9	protein maturation by protein folding	GO:022417	10.2	CALR, FKBP1B
10	regulation of heart rate by cardiac conduction	GO:086091	10.2	ANK2, SCN5A, KCNH2
11	cellular response to caffeine	GO:071313	10.1	RYR1, RYR2, CASQ2, RYR3
12	regulation of heart rate	GO:002027	10.1	ANK2, CASQ2, SCN5A, OXT
13	angiotensin catabolic process in blood	GO:002005	10.0	ACE, ACE2
14	cellular calcium ion homeostasis	GO:006874	10.0	RYR2, CALR, RYR3, ANK2
15	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	9.9	ACE2, ACE
16	cellular response to calcium ion	GO:071277	9.9	SCN5A, RYR3, ASPH
17	regulation of heart contraction	GO:008016	9.9	KCNH2, GJA1, KCNE2, KCNIP2
18	regulation of ventricular cardiomyocyte membrane repolarization	GO:060307	9.9	SCN5A, ANK2
19	potassium ion transport	GO:006813	9.9	ABCC9, KCNE2, KCNJ2, KCNIP2, KCNH2
20	regulation of vasodilation	GO:042312	9.5	NPPB, ACE, ACE2
21	synaptic transmission	GO:007268	9.2	GNAI2, HTR3A, KCNJ2, ABCC9, KCNIP2, KCNH2
22	response to peptide hormone stimulus	GO:043434	9.1	TIMP1, OXT, NPPB, GJA1
23	muscle contraction	GO:006936	INF	KCNIP2, KCNH2, KCNE2, ASPH, FKBP1B, GJA1
24	negative regulation of ryanodine-sensitive calcium-release channel activity	GO:060315	INF	ASPH, , CASQ2

Molecular functions related to ventricular tachycardia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium-release channel activity	GO:015278	9.9	RYR2, RYR3, RYR1
2	peptidyl-dipeptidase activity	GO:008241	9.8	ACE2, ACE
3	ryanodine-sensitive calcium-release channel activity	GO:005219	9.8	FKBP1B, RYR1, RYR2, RYR3
4	calcium ion binding	GO:005509	8.9	RYR3, KCNIP2, ASPH, CASQ1, CALR, CASQ2
5	ion channel binding	GO:044325	INF	SCN5A, , ANK2, ABCC9