MCID: VNT009
MIFTS: 18

Ventricular Tachycardia, Idiopathic malady

Genetic diseases, Rare diseases categories

Aliases & Classifications for Ventricular Tachycardia, Idiopathic

About this section

Aliases & Descriptions for Ventricular Tachycardia, Idiopathic:

Name: Ventricular Tachycardia, Idiopathic 49 11
 
Familial Ventricular Tachycardia 45 24 65


Classifications:



External Ids:

OMIM49 192605

Summaries for Ventricular Tachycardia, Idiopathic

About this section
MalaCards based summary: Ventricular Tachycardia, Idiopathic, also known as familial ventricular tachycardia, is related to catecholaminergic polymorphic ventricular tachycardia and cardiomyopathy, and has symptoms including autosomal dominant inheritance, sudden cardiac death and abnormality of metabolism/homeostasis. An important gene associated with Ventricular Tachycardia, Idiopathic is GNAI2 (Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2), and among its related pathways are Presynaptic function of Kainate receptors and Insulin secretion. Related mouse phenotype digestive/alimentary.

Description from OMIM:49 192605

Related Diseases for Ventricular Tachycardia, Idiopathic

About this section

Diseases related to Ventricular Tachycardia, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1catecholaminergic polymorphic ventricular tachycardia10.2
2cardiomyopathy10.2
3bile reflux9.8GIP, GNAI2
4ventricular tachycardia, idiopathic9.7GIP, GNAI2

Symptoms for Ventricular Tachycardia, Idiopathic

About this section

Symptoms by clinical synopsis from OMIM:

192605

Clinical features from OMIM:

192605

HPO human phenotypes related to Ventricular Tachycardia, Idiopathic:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 sudden cardiac death HP:0001645
3 abnormality of metabolism/homeostasis HP:0001939
4 paroxysmal ventricular tachycardia HP:0004751

Drugs & Therapeutics for Ventricular Tachycardia, Idiopathic

About this section

Drugs for Ventricular Tachycardia, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EplerenoneapprovedPhase 387107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
2MineralocorticoidsPhase 3294
3lenograstimPhase 21108
4
Remifentanilapproved386132875-61-760815
Synonyms:
1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester
132539-07-2 (mono-hydrochloride)
132875-61-7
3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester
4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester
AC1L1TZ8
AC1Q5ZGR
BIDD:GT0029
C08021
CHEBI:8802
CHEMBL1005
CID60815
D08473
DB00899
 
DEA No. 9739
GI 87084B
GI 87084X
GI87084B
L001266
LS-115982
MolPort-004-286-006
REMIFENTANIL
Remifentanil (INN)
Remifentanil [INN:BAN]
Remifentanyl
UNII-P10582JYYK
Ultiva
Ultiva (TN)
methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Registry of Unexplained Cardiac ArrestRecruitingNCT00292032Phase 3
2PHOspholamban RElated CArdiomyopathy STudy - InterventionRecruitingNCT01857856Phase 3
3Bone Marrow Derived Adult Stem Cells for Dilated CardiomyopathyCompletedNCT01302171Phase 2
4Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular TachycardiaCompletedNCT01901575
5Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-OligosaccharideCompletedNCT00802971
6Calmodulin Gene Mutations in Patients With Ventricular Arrhythmia of Unknown Origin - A Screening StudyNot yet recruitingNCT01947543
7Stereotaxis Idiopathic Ventricular Tachycardia (VT) StudyTerminatedNCT01401608

Search NIH Clinical Center for Ventricular Tachycardia, Idiopathic

Genetic Tests for Ventricular Tachycardia, Idiopathic

About this section

Genetic tests related to Ventricular Tachycardia, Idiopathic:

id Genetic test Affiliating Genes
1 Familial Ventricular Tachycardia24

Anatomical Context for Ventricular Tachycardia, Idiopathic

About this section

Animal Models for Ventricular Tachycardia, Idiopathic or affiliated genes

About this section

MGI Mouse Phenotypes related to Ventricular Tachycardia, Idiopathic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1GIP, GNAI2

Publications for Ventricular Tachycardia, Idiopathic

About this section

Variations for Ventricular Tachycardia, Idiopathic

About this section

Expression for genes affiliated with Ventricular Tachycardia, Idiopathic

About this section
Search GEO for disease gene expression data for Ventricular Tachycardia, Idiopathic.

Pathways for genes affiliated with Ventricular Tachycardia, Idiopathic

About this section

GO Terms for genes affiliated with Ventricular Tachycardia, Idiopathic

About this section

Sources for Ventricular Tachycardia, Idiopathic

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet