MCID: VNT009
MIFTS: 23

Ventricular Tachycardia, Idiopathic malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Ventricular Tachycardia, Idiopathic

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Aliases & Descriptions for Ventricular Tachycardia, Idiopathic:

Name: Ventricular Tachycardia, Idiopathic 50 12
 
Familial Ventricular Tachycardia 46 25 66

Characteristics:

HPO:

62
ventricular tachycardia, idiopathic:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM50 192605

Summaries for Ventricular Tachycardia, Idiopathic

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MalaCards based summary: Ventricular Tachycardia, Idiopathic, also known as familial ventricular tachycardia, is related to catecholaminergic polymorphic ventricular tachycardia and cardiomyopathy, and has symptoms including sudden cardiac death, abnormality of metabolism/homeostasis and paroxysmal ventricular tachycardia. An important gene associated with Ventricular Tachycardia, Idiopathic is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways are Oxytocin signaling pathway and cGMP-PKG signaling pathway. Affiliated tissues include bone, and related mouse phenotype normal.

Description from OMIM:50 192605

Related Diseases for Ventricular Tachycardia, Idiopathic

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Diseases related to Ventricular Tachycardia, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1catecholaminergic polymorphic ventricular tachycardia11.1
2cardiomyopathy9.8
3ventricular tachycardia, idiopathic8.9GIP, GNAI2, RYR2

Symptoms for Ventricular Tachycardia, Idiopathic

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Symptoms by clinical synopsis from OMIM:

192605

Clinical features from OMIM:

192605

HPO human phenotypes related to Ventricular Tachycardia, Idiopathic:

id Description Frequency HPO Source Accession
1 sudden cardiac death HP:0001645
2 abnormality of metabolism/homeostasis HP:0001939
3 paroxysmal ventricular tachycardia HP:0004751

Drugs & Therapeutics for Ventricular Tachycardia, Idiopathic

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Drugs for Ventricular Tachycardia, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1diureticsPhase 31338
2
SpironolactonePhase 32171952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
3
EplerenonePhase 392107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
4lenograstimPhase 21178
5
Remifentanil430132875-61-760815
Synonyms:
1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester
132539-07-2 (mono-hydrochloride)
132875-61-7
3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester
4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester
AC1L1TZ8
AC1Q5ZGR
BIDD:GT0029
C08021
CHEBI:8802
CHEMBL1005
CID60815
D08473
DB00899
 
DEA No. 9739
GI 87084B
GI 87084X
GI87084B
L001266
LS-115982
MolPort-004-286-006
REMIFENTANIL
Remifentanil (INN)
Remifentanil [INN:BAN]
Remifentanyl
UNII-P10582JYYK
Ultiva
Ultiva (TN)
methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate

Interventional clinical trials:

idNameStatusNCT IDPhase
1Registry of Unexplained Cardiac ArrestRecruitingNCT00292032Phase 3
2PHOspholamban RElated CArdiomyopathy STudy - InterventionRecruitingNCT01857856Phase 3
3Bone Marrow Derived Adult Stem Cells for Dilated CardiomyopathyCompletedNCT01302171Phase 2
4Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular TachycardiaCompletedNCT01901575
5Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-OligosaccharideCompletedNCT00802971
6EGM Analysis in Idiopathic Outflow Tract Ventricular ArrhythmiaEnrolling by invitationNCT02722577
7Calmodulin Gene Mutations in Patients With Ventricular Arrhythmia of Unknown Origin - A Screening StudyNot yet recruitingNCT01947543
8Stereotaxis Idiopathic Ventricular Tachycardia (VT) StudyTerminatedNCT01401608

Search NIH Clinical Center for Ventricular Tachycardia, Idiopathic

Genetic Tests for Ventricular Tachycardia, Idiopathic

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Genetic tests related to Ventricular Tachycardia, Idiopathic:

id Genetic test Affiliating Genes
1 Familial Ventricular Tachycardia25

Anatomical Context for Ventricular Tachycardia, Idiopathic

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MalaCards organs/tissues related to Ventricular Tachycardia, Idiopathic:

34
Bone

Animal Models for Ventricular Tachycardia, Idiopathic or affiliated genes

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MGI Mouse Phenotypes related to Ventricular Tachycardia, Idiopathic:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.7GIP, GNAI2, RYR2

Publications for Ventricular Tachycardia, Idiopathic

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Variations for Ventricular Tachycardia, Idiopathic

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Expression for genes affiliated with Ventricular Tachycardia, Idiopathic

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Search GEO for disease gene expression data for Ventricular Tachycardia, Idiopathic.

Pathways for genes affiliated with Ventricular Tachycardia, Idiopathic

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GO Terms for genes affiliated with Ventricular Tachycardia, Idiopathic

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Sources for Ventricular Tachycardia, Idiopathic

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet