MCID: VNT009
MIFTS: 16

Ventricular Tachycardia, Idiopathic malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Ventricular Tachycardia, Idiopathic

Aliases & Descriptions for Ventricular Tachycardia, Idiopathic:

Name: Ventricular Tachycardia, Idiopathic 54 13
Familial Ventricular Tachycardia 50 29 69

Characteristics:

HPO:

32
ventricular tachycardia, idiopathic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 192605

Summaries for Ventricular Tachycardia, Idiopathic

MalaCards based summary : Ventricular Tachycardia, Idiopathic, also known as familial ventricular tachycardia, is related to catecholaminergic polymorphic ventricular tachycardia, and has symptoms including sudden cardiac death, abnormality of metabolism/homeostasis and paroxysmal ventricular tachycardia. An important gene associated with Ventricular Tachycardia, Idiopathic is GNAI2 (G Protein Subunit Alpha I2). The drugs Spironolactone and Eplerenone have been mentioned in the context of this disorder.

Description from OMIM: 192605

Related Diseases for Ventricular Tachycardia, Idiopathic

Diseases related to Ventricular Tachycardia, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 catecholaminergic polymorphic ventricular tachycardia 11.0

Symptoms & Phenotypes for Ventricular Tachycardia, Idiopathic

Symptoms by clinical synopsis from OMIM:

192605

Clinical features from OMIM:

192605

Human phenotypes related to Ventricular Tachycardia, Idiopathic:

32
id Description HPO Frequency HPO Source Accession
1 sudden cardiac death 32 HP:0001645
2 abnormality of metabolism/homeostasis 32 HP:0001939
3 paroxysmal ventricular tachycardia 32 HP:0004751

Drugs & Therapeutics for Ventricular Tachycardia, Idiopathic

Drugs for Ventricular Tachycardia, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
2
Eplerenone Approved Phase 3 107724-20-9 150310 443872
3 diuretics Phase 3
4 Natriuretic Agents Phase 3
5 Hormone Antagonists Phase 3
6 Hormones Phase 3
7 Diuretics, Potassium Sparing Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
9 Mineralocorticoid Receptor Antagonists Phase 3
10 Mineralocorticoids Phase 3
11
Lenograstim Approved Phase 2 135968-09-1
12 Adjuvants, Immunologic Phase 2
13
Remifentanil Approved 132875-61-7 60815
14 Analgesics
15 Narcotics
16 Analgesics, Opioid
17 Anesthetics
18 Anesthetics, General
19 Anesthetics, Intravenous
20 Peripheral Nervous System Agents
21 Hypnotics and Sedatives
22 Central Nervous System Depressants

Interventional clinical trials:


id Name Status NCT ID Phase
1 PHOspholamban RElated CArdiomyopathy STudy - Intervention Recruiting NCT01857856 Phase 3
2 Registry of Unexplained Cardiac Arrest Recruiting NCT00292032 Phase 3
3 Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy Completed NCT01302171 Phase 2
4 Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular Tachycardia Completed NCT01901575
5 EGM Analysis in Idiopathic Outflow Tract Ventricular Arrhythmia Completed NCT02722577
6 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971
7 Zero-fluoroscopic Ablation Versus Conventional Fluoroscopic Ablation for the Treatment of Ventricular Arrhythmias Recruiting NCT03041519
8 Calmodulin Gene Mutations in Patients With Ventricular Arrhythmia of Unknown Origin - A Screening Study Not yet recruiting NCT01947543
9 Stereotaxis Idiopathic Ventricular Tachycardia (VT) Study Terminated NCT01401608

Search NIH Clinical Center for Ventricular Tachycardia, Idiopathic

Genetic Tests for Ventricular Tachycardia, Idiopathic

Genetic tests related to Ventricular Tachycardia, Idiopathic:

id Genetic test Affiliating Genes
1 Familial Ventricular Tachycardia 29

Anatomical Context for Ventricular Tachycardia, Idiopathic

Publications for Ventricular Tachycardia, Idiopathic

Variations for Ventricular Tachycardia, Idiopathic

Expression for Ventricular Tachycardia, Idiopathic

Search GEO for disease gene expression data for Ventricular Tachycardia, Idiopathic.

Pathways for Ventricular Tachycardia, Idiopathic

GO Terms for Ventricular Tachycardia, Idiopathic

Sources for Ventricular Tachycardia, Idiopathic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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