MCID: VNT009
MIFTS: 21

Ventricular Tachycardia, Idiopathic malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Ventricular Tachycardia, Idiopathic

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Aliases & Descriptions for Ventricular Tachycardia, Idiopathic:

Name: Ventricular Tachycardia, Idiopathic 49 11
 
Familial Ventricular Tachycardia 45 24 65

Characteristics:

HPO:

61
ventricular tachycardia, idiopathic:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM49 192605
UMLS65 C0340485

Summaries for Ventricular Tachycardia, Idiopathic

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MalaCards based summary: Ventricular Tachycardia, Idiopathic, also known as familial ventricular tachycardia, is related to catecholaminergic polymorphic ventricular tachycardia and kearns-sayre syndrome, and has symptoms including paroxysmal ventricular tachycardia, abnormality of metabolism/homeostasis and sudden cardiac death. An important gene associated with Ventricular Tachycardia, Idiopathic is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways are Presynaptic function of Kainate receptors and Insulin secretion. Affiliated tissues include bone.

Description from OMIM:49 192605

Related Diseases for Ventricular Tachycardia, Idiopathic

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Diseases related to Ventricular Tachycardia, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1catecholaminergic polymorphic ventricular tachycardia11.5
2kearns-sayre syndrome10.0
3priapism10.0
4ventricular tachycardia, idiopathic9.7GIP, GNAI2

Symptoms for Ventricular Tachycardia, Idiopathic

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Symptoms by clinical synopsis from OMIM:

192605

Clinical features from OMIM:

192605

HPO human phenotypes related to Ventricular Tachycardia, Idiopathic:

id Description Frequency HPO Source Accession
1 paroxysmal ventricular tachycardia HP:0004751
2 abnormality of metabolism/homeostasis HP:0001939
3 sudden cardiac death HP:0001645

Drugs & Therapeutics for Ventricular Tachycardia, Idiopathic

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Drugs for Ventricular Tachycardia, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EplerenoneapprovedPhase 389107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
2Mineralocorticoid Receptor AntagonistsPhase 3284
3MineralocorticoidsPhase 3301
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 39988
5Natriuretic AgentsPhase 31403
6HormonesPhase 311748
7Diuretics, Potassium SparingPhase 31445
8Hormone AntagonistsPhase 310002
9diureticsPhase 31194
10lenograstimPhase 21134
11Immunologic FactorsPhase 218483
12Adjuvants, ImmunologicPhase 21783
13
Remifentanilapproved409132875-61-760815
Synonyms:
1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester
132539-07-2 (mono-hydrochloride)
132875-61-7
3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester
4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester
AC1L1TZ8
AC1Q5ZGR
BIDD:GT0029
C08021
CHEBI:8802
CHEMBL1005
CID60815
D08473
DB00899
 
DEA No. 9739
GI 87084B
GI 87084X
GI87084B
L001266
LS-115982
MolPort-004-286-006
REMIFENTANIL
Remifentanil (INN)
Remifentanil [INN:BAN]
Remifentanyl
UNII-P10582JYYK
Ultiva
Ultiva (TN)
methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate
14Hypnotics and Sedatives2032
15Peripheral Nervous System Agents18510
16Central Nervous System Depressants10016
17Narcotics2709
18Anesthetics, Intravenous1943
19Analgesics9358
20Analgesics, Opioid2304
21Anesthetics7385
22Anesthetics, General2274

Interventional clinical trials:

idNameStatusNCT IDPhase
1Registry of Unexplained Cardiac ArrestRecruitingNCT00292032Phase 3
2PHOspholamban RElated CArdiomyopathy STudy - InterventionRecruitingNCT01857856Phase 3
3Bone Marrow Derived Adult Stem Cells for Dilated CardiomyopathyCompletedNCT01302171Phase 2
4Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular TachycardiaCompletedNCT01901575
5Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-OligosaccharideCompletedNCT00802971
6EGM Analysis in Idiopathic Outflow Tract Ventricular ArrhythmiaEnrolling by invitationNCT02722577
7Calmodulin Gene Mutations in Patients With Ventricular Arrhythmia of Unknown Origin - A Screening StudyNot yet recruitingNCT01947543
8Stereotaxis Idiopathic Ventricular Tachycardia (VT) StudyTerminatedNCT01401608

Search NIH Clinical Center for Ventricular Tachycardia, Idiopathic

Genetic Tests for Ventricular Tachycardia, Idiopathic

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Anatomical Context for Ventricular Tachycardia, Idiopathic

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MalaCards organs/tissues related to Ventricular Tachycardia, Idiopathic:

33
Bone

Animal Models for Ventricular Tachycardia, Idiopathic or affiliated genes

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Publications for Ventricular Tachycardia, Idiopathic

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Variations for Ventricular Tachycardia, Idiopathic

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Expression for genes affiliated with Ventricular Tachycardia, Idiopathic

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Search GEO for disease gene expression data for Ventricular Tachycardia, Idiopathic.

Pathways for genes affiliated with Ventricular Tachycardia, Idiopathic

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GO Terms for genes affiliated with Ventricular Tachycardia, Idiopathic

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Biological processes related to Ventricular Tachycardia, Idiopathic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00071659.1GIP, GNAI2

Sources for Ventricular Tachycardia, Idiopathic

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet