VKC
MCID: VRN004
MIFTS: 40

Vernal Keratoconjunctivitis (VKC) malady

Eye diseases category

Summaries for Vernal Keratoconjunctivitis

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards: Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. The compounds pge2 and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotype immune system.

Wikipedia:63 Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting... more...

Aliases & Classifications for Vernal Keratoconjunctivitis

About this section
Sources:
42NIH Rare Diseases, 48Orphanet, 44Novoseek, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
vernal keratoconjunctivitis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

vernal keratoconjunctivitis 42 48
keratoconjunctivitis, vernal 60
keratoconjunctivitis vernal 44
spring catarrh 48
vkc 42


External Ids:

ICD10 via Orphanet26 H16.2
SNOMED-CT via Orphanet57 317349009
UMLS via Orphanet61 C0022577

Related Diseases for Vernal Keratoconjunctivitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.0CCL11, RNASE3
2conjunctivitis31.0IGHE, RNASE3
3allergic conjunctivitis30.9IGHE, RNASE3, CCL11
4keratitis30.7CXCL9
5giant papillary conjunctivitis30.4CCL11, RNASE3
6corneal ulcer30.4CCL11, PRG2
7asthma30.4IGHE, RNASE3
8eosinophilia30.4RNASE3, CCL11, CCL17, CCL7, CCL24, IGHE
9allergic rhinitis30.2RNASE3, IGHE, CCL11
10atopic dermatitis30.2CCL22, CCL11, CCL17, RNASE3
11uveitis30.2CXCL11, CCL11, CXCL9
12rhinitis30.2CCL11, CCL7, PRG2, CMA1, RNASE3, IGHE
13dermatitis30.2CCL17, CXCL11, CCL11, CCL22, CXCL9, CMA1
14allergic asthma30.2CCL24, CCL11, CCL17, CCL7, ICAM3, IGHE
15vernal conjunctivitis10.7
16keratoconus10.6
17trachoma10.3
18conjunctival pigmentation10.3
19corneal deposit10.3
20glaucoma10.3
21papillary conjunctivitis10.3
22porphyria10.2
23graft versus host disease10.2
24limbal stem cell deficiency10.2
25corneal disease10.2
26steroid-induced glaucoma - borderline10.2
27corneal ectasia10.2
28ocular hypertension10.2
29mooren's ulcer10.2
30amblyopia10.2
31conjunctival deposit10.2
32eye disease10.2
33hypertension10.2
34retinitis10.2
35steroid-induced glaucoma10.2
36hepatitis10.0CCL11
37eosinophilic esophagitis10.0CCL11
38encephalomyelitis10.0CCL7
39churg-strauss syndrome10.0RNASE3
40onchocerciasis10.0RNASE3
41periodontitis10.0MMP8
42malaria10.0CXCL9
43bronchiolitis obliterans10.0MMP8
44purpura10.0THPO
45myelofibrosis10.0THPO
46eosinophilic gastroenteritis10.0CCL11, IGHE
47intrinsic asthma10.0RNASE3, IGHE
48esophagitis10.0PRG2, CCL11
49sarcoidosis10.0CXCL9, CCL11
50chronic eosinophilic pneumonia10.0RNASE3, CCL11

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to vernal keratoconjunctivitis

Clinical Features for Vernal Keratoconjunctivitis

About this section

Drugs & Therapeutics for Vernal Keratoconjunctivitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vernal Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Vernal Keratoconjunctivitis

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Search CenterWatch for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

About this section

Anatomical Context for Vernal Keratoconjunctivitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

32
Eye

Animal Models for Vernal Keratoconjunctivitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.3THPO, CCL11, CCL1, CCL17, CCL7, PRG2

Publications for Vernal Keratoconjunctivitis

About this section

Genetic Variations for Vernal Keratoconjunctivitis

About this section

Expression for genes affiliated with Vernal Keratoconjunctivitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for genes affiliated with Vernal Keratoconjunctivitis

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MMP13, MMP10, MMP8
2
Hide members
10.2MMP10, MMP8, MMP13
310.2CCL11, CXCL11, CXCL9
410.2CCL11, IGHE, CCL17
5
Hide members
10.1CMA1, MMP8, MMP10, MMP13
6
Immune response CCR3 signaling in eosinophils
Hide members
10.1CCL11, CCL7, CCL8, CCL24
7
Cell adhesion ECM remodeling
Hide members
10.0MMP8, CMA1, HBEGF, MMP13, MMP10
8
Hide members
9.9CXCL11, CXCL9, CCL7, CCL17, CCL11, CCL22
99.9CCL22, CCL17, CCL7, CXCL11, CXCL9, CCL11
10
Hide members
9.7CCL11, THPO, CCL7, CCL17, CCL1, CCL24
11
Hide members
9.7CCL22, CCL11, CCL17, CMA1, CXCL9, CXCL11
12
Hide members
9.6CCL7, CXCL9, CCL11, CCL22, CCL24, CCL1
13
Hide members
9.6CCL1, CCL8, CXCL9, CXCL11, CCL22, CCL24
14
Hide members
9.5CCL22, THPO, CXCL9, CXCL11, CCL7, CCL17
15
Hide members
9.5CCL22, CCL11, CCL24, CCL1, CCL8, CCL17
16
Hide members
9.4THPO, CXCL9, CXCL11, CCL22, CCL24, CCL11
17
Hide members
9.2CCL22, MMP10, CCL24, CCL11, MMP13, CXCL9

Compounds for genes affiliated with Vernal Keratoconjunctivitis

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1pge24410.7CCL11
2indomethacin44 59 28 1113.6PRG2
3unicap4410.6RNASE3, IGHE, CCL11
4anti-histamine4410.6RNASE3, IGHE, CCL11
5sodium cromoglycate4410.6CCL11, IGHE, RNASE3
6cetirizine44 28 11 2413.6CCL11, IGHE, RNASE3
7(4-aminophenyl)mercuric acetate4410.6MMP10, MMP8, MMP13
8larc4410.5CCL17, CCL22, CCL7
9ketotifen44 1111.5RNASE3, IGHE, CCL11
10uk 3833675910.5MMP13, MMP8, MMP10
11gm 60015910.5MMP8, MMP10, MMP13
12batimastat44 59 1112.5MMP13, MMP8, MMP10, HBEGF
13groalpha4410.5CXCL9, CCL7, CCL11, MMP13
14gi 254023x5910.5MMP8, MMP10, MMP13
15pgd24410.5PRG2, CCL11, IGHE, RNASE3
16leukotriene b444 59 2412.5CCL11, RNASE3, CCL7, CCL8, CCL22
17montelukast44 49 28 1113.4CCL11, RNASE3, IGHE
18methacholine44 1111.4CCL11, IGHE, PRG2, CCL22, RNASE3
19oxygen44 2411.4CCL7, PRG2, MMP8, MMP13, CCL11
20allergens4410.4RNASE3, PRG2, IGHE, CMA1, CCL17, CCL11
21matrigel4410.3HBEGF, CCL11, THPO, MMP10, MMP13
22latex4410.3HBEGF, IGHE, THPO, RNASE3
23marimastat44 59 1112.3MMP13, MMP10, MMP8
24p0024410.3MMP8, RNASE3, MMP13, THPO
25barbiturate4410.3MMP13, MMP8
26rantes4410.3CCL8, THPO, CXCL11, RNASE3, ICAM3, CCL7
27ltc44410.3PRG2, RNASE3, CCL11
28sb 20358044 5911.3MMP13, CCL22, THPO, CCL11, HBEGF
29fibrinogen4410.3THPO, CCL22, CCL17, HBEGF, MMP13, RNASE3
30cyclosporin a44 28 5912.3RNASE3, CXCL11, MMP8, IGHE, CCL17, CCL11
31prednisolone44 28 1112.3CCL11, IGHE, MMP13, RNASE3
32fmlp4410.2CCL11, CCL8, THPO, RNASE3, PRG2, ICAM3
33genistein44 28 59 2 11 2415.2PRG2, CCL11, CCL7, HBEGF, MMP13, MMP8
34fluticasone propionate44 49 59 1113.2CCL11, RNASE3, IGHE
35polysaccharide4410.2RNASE3, HBEGF, IGHE, ICAM3, THPO
36heparin44 28 11 2413.2CCL11, CMA1, MMP13, RNASE3, HBEGF, PRG2
37budesonide44 49 1112.1CCL11, IGHE, RNASE3
38actinomycin d4410.1CCL7, MMP13, IGHE, PRG2, HBEGF, THPO
39ccl444 2811.1MMP13, CXCL9, CXCL11, CCL7, CCL17, CCL8
40ccl344 2811.1CCL24, CCL22, CCL11, CCL1, CCL8, CCL17
41retinoic acid44 2411.0RNASE3, HBEGF, IGHE, PRG2, CCL11, THPO
42vegf4410.0MMP8, MMP13, THPO, MMP10, CCL11, IGHE
43histamine44 28 2412.0THPO, CMA1, CXCL9, IGHE, PRG2, CCL7
44tarc449.9CXCL9, CCL17, CCL7, IGHE, CXCL11, CCL8
45nitric oxide44 11 2411.9MMP8, THPO, MMP13, CCL17, HBEGF, CXCL9
46oligonucleotide449.9MMP10, MMP8, THPO, MMP13, CXCL11, CCL1
47salbutamol44 49 28 11 2413.9CCL11, IGHE, RNASE3
48tyrosine449.9MMP13, HBEGF, CCL8, THPO, CCL7, ICAM3
49dexamethasone44 49 28 1112.8RNASE3, CXCL9, CCL22, CXCL11, CCL11, MMP13
50calcium44 49 11 2412.2CMA1, THPO, MMP8, MMP10, MMP13, CCL22

GO Terms for genes affiliated with Vernal Keratoconjunctivitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1MMP8, CRISP3, MMP13, MMP10
2extracellular spaceGO:0056159.1CCL22, THPO, MMP8, MMP10, MMP13, CXCL9
3extracellular regionGO:0055768.8CMA1, IGHE, CXCL11, RNASE3, HBEGF, MMP13

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.4CCL7, CCL11, CCL24
2collagen catabolic processGO:03057410.4MMP10, MMP13, MMP8
3extracellular matrix disassemblyGO:02261710.3MMP8, MMP13, CMA1, MMP10
4positive regulation of angiogenesisGO:04576610.3CCL11, CCL24, CMA1
5cellular calcium ion homeostasisGO:00687410.3CCL8, CCL1, CCL11, CCL7
6positive regulation of Rac GTPase activityGO:03285510.3CCL24, CCL11
7positive regulation of cell migrationGO:03033510.3CCL24, CCL11, CCL7, HBEGF
8cytoskeleton organizationGO:00701010.2CCL7, CCL24, CCL11
9extracellular matrix organizationGO:03019810.2MMP13, MMP10, CMA1, MMP8
10regulation of cell shapeGO:00836010.1CCL24, CCL7, CCL11
11cell-cell signalingGO:00726710.1CXCL9, CXCL11, CCL24, CCL8, CCL17, CCL7
12inflammatory responseGO:00695410.0CXCL9, CCL22, CXCL11, CCL7, CCL17, CCL8
13chemotaxisGO:0069359.9CCL11, CCL24, CCL22, CCL1, CXCL9, CXCL11
14response to virusGO:0096159.9CCL11, CCL22, CCL8
15signal transductionGO:0071659.9CXCL9, CCL1, CCL22, CCL24, CCL11, CCL8
16immune responseGO:0069559.7CCL8, CCL17, CCL7, PRG2, IGHE, CXCL11

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.2MMP8, MMP10, MMP13
2heparin bindingGO:0082019.8CCL8, CCL7, PRG2, HBEGF
3chemokine activityGO:0080099.5CXCL9, CCL22, CCL24, CCL11, CCL1, CCL8

Products for genes affiliated with Vernal Keratoconjunctivitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vernal Keratoconjunctivitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet