VKC
MCID: VRN004
MIFTS: 46

Vernal Keratoconjunctivitis (VKC) malady

Eye category

Summaries for Vernal Keratoconjunctivitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

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NIH Rare Diseases:43 Vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards: Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to allergic conjunctivitis and atopy. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. The compounds pge2 and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and b cells, and related mouse phenotype immune system.

Wikipedia:64 Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting... more...

Aliases & Classifications for Vernal Keratoconjunctivitis

Sources:
43NIH Rare Diseases, 49Orphanet, 45Novoseek, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Characteristics (Orphanet epidemiological data):

49
vernal keratoconjunctivitis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

vernal keratoconjunctivitis 43 49
keratoconjunctivitis, vernal 61
keratoconjunctivitis vernal 45
spring catarrh 49
vkc 43


External Ids:

ICD10 via Orphanet26 H16.2
SNOMED-CT via Orphanet58 317349009
UMLS via Orphanet62 C0022577

Related Diseases for Vernal Keratoconjunctivitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis30.9IGHE, RNASE3, CCL11
2atopy30.6PRG2, CCL11, CMA1, IGHE, RNASE3, CCL17
3giant papillary conjunctivitis30.5CCL11, RNASE3
4asthma30.5IGHE, RNASE3
5allergic rhinitis30.3RNASE3, IGHE, CCL11
6atopic dermatitis30.3CCL22, CCL11, CCL17, RNASE3
7uveitis30.3CXCL11, CCL11, CXCL9
8allergic asthma30.3CCL24, CCL11, CCL17, CCL7, ICAM3, IGHE
9vernal conjunctivitis10.7
10atopic keratoconjunctivitis10.7
11vernal keratitis10.6
12trachoma10.4
13conjunctival pigmentation10.4
14congenital porphyria10.2
15graft versus host disease10.2
16limbal stem cell deficiency10.2
17corneal disease10.2
18corneal ectasia10.2
19ocular hypertension10.2
20mooren's ulcer10.2
21amblyopia10.2
22steroid-induced glaucoma10.2
23anterior uveitis10.2
24hepatitis10.0CCL11
25eosinophilic esophagitis10.0CCL11
26encephalomyelitis10.0CCL7
27churg-strauss syndrome10.0RNASE3
28onchocerciasis10.0RNASE3
29keratoconjunctivitis10.0CCL11, RNASE3
30periodontitis10.0MMP8
31malaria10.0CXCL9
32bronchiolitis obliterans10.0MMP8
33keratitis10.0CXCL9
34purpura10.0THPO
35myelofibrosis10.0THPO
36eosinophilic gastroenteritis10.0CCL11, IGHE
37conjunctivitis10.0IGHE, RNASE3
38intrinsic asthma10.0RNASE3, IGHE
39esophagitis10.0PRG2, CCL11
40sarcoidosis10.0CXCL9, CCL11
41chronic eosinophilic pneumonia10.0RNASE3, CCL11
42ovarian cancer10.0HBEGF
43paragonimiasis10.0IGHE, CCL17
44galactosemia10.0THPO
45schistosomiasis10.0IGHE, RNASE3
46chorioamnionitis10.0MMP8
47bronchiolitis10.0CCL11, IGHE, RNASE3
48myocardial infarction10.0CCL11, MMP13
49helminthiasis10.0IGHE, RNASE3
50vasculitis10.0PRG2

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to vernal keratoconjunctivitis

Clinical Features for Vernal Keratoconjunctivitis

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vernal Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Vernal Keratoconjunctivitis

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Search CenterWatch for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

33
Bone marrow, T cells, B cells

Animal Models for Vernal Keratoconjunctivitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.3THPO, CCL11, CCL1, CCL17, CCL7, PRG2

Publications for Vernal Keratoconjunctivitis

Sources:
51PubMed
See all sources

Articles related to Vernal Keratoconjunctivitis:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Vernal keratoconjunctivitis: an update. (23038763)
2013
2
Assessment of Corneal Alterations by Confocal Microscopy in Vernal Keratoconjunctivitis. (24074451)
2013
3
Management, clinical outcomes, and complications of shield ulcers in vernal keratoconjunctivitis. (23218707)
2013
4
Tear cytokine levels in vernal keratoconjunctivitis: the effect of topical 0.05% cyclosporine a therapy. (23676782)
2013
5
Brimonidine Allergy Presenting as Vernal-like Keratoconjunctivitis. (23632412)
2013
6
Measure of keratoconus progression in patients with vernal keratoconjunctivitis using scanning slit topography. (23092830)
2013
7
New insights into childhood Vernal keratoconjunctivitis-associated factors. (22963206)
2012
8
The efficacy of topical interferon alpha 2b treatment in refractory vernal keratoconjunctivitis. (22409566)
2012
9
A double-masked comparison of 0.1% tacrolimus ointment and 2% cyclosporine eye drops in the treatment of vernal keratoconjunctivitis in children. (23156846)
2012
10
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
11
In vivo laser scanning confocal microscopy of vernal keratoconjunctivitis. (20662846)
2011
12
Childhood chronic anterior uveitis associated with vernal keratoconjunctivitis (VKC): successful treatment with topical tacrolimus. Case series. (22047067)
2011
13
Transforming growth factor-I^/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis. (20977504)
2011
14
Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis. (21545429)
2011
15
Nasal inflammation in vernal keratoconjunctivitis. (20159263)
2010
16
Modern approach to managing vernal keratoconjunctivitis. (20425012)
2010
17
Hyposensitization in the treatment of resistant cases of vernal keratoconjunctivitis. (20670088)
2010
18
Vernal keratoconjunctivitis at Guinness Eye Centre, Luth (a five year study). (19062462)
2008
19
Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients. (17585003)
2007
20
Microbial keratitis in keratoglobus-associated vernal keratoconjunctivitis and atopic dermatitis. (17496706)
2007
21
Clinical grading of vernal keratoconjunctivitis. (17873585)
2007
22
Conjunctival Inclusion Cysts in Long-standing Chronic Vernal Keratoconjunctivitis. (18063892)
2007
23
Unilateral vernal keratoconjunctivitis: a case report. (18050126)
2007
24
Isolated large limbal nodule as the presenting feature of vernal keratoconjunctivitis. (17274337)
2007
25
Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma. (17517101)
2007
26
A clinicopathological analysis of the efficacy of lodoxamide 0.1% eye drops on the conjunctiva of patients with vernal keratoconjunctivitis seen at Guinness Eye Centre, Lagos University Teaching Hospital. (16633377)
2006
27
Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis. (17200658)
2006
28
Efficiency of olopatadine hydrochloride 0.1% in the treatment of vernal keratoconjunctivitis and goblet cell density. (16245967)
2005
29
Surgical management of corneal plaques in vernal keratoconjunctivitis: a clinicopathologic study. (15257001)
2004
30
Vernal keratoconjunctivitis in Thailand. (12931748)
2003
31
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
32
Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis. (12194580)
2002
33
Perilimbal conjunctival pigmentation in vernal keratoconjunctivitis: a new sign. (11973399)
2002
34
Atopic and vernal keratoconjunctivitis: a model for studying atopic disease. (10374055)
1999
35
Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: a flow-cytometric study. (9483586)
1998
36
Adhesion molecules in vernal keratoconjunctivitis. (9497473)
1997
37
An immunohistochemical study of topical cyclosporine in vernal keratoconjunctivitis. (8623884)
1996
38
Supratarsal injection of corticosteroid in the treatment of refractory vernal keratoconjunctivitis. (8597266)
1996
39
Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis. (8588697)
1995
40
Vernal keratoconjunctivitis: a model of 5q cytokine gene cluster disease. (7613225)
1995
41
Estrogen and progesterone receptors in vernal keratoconjunctivitis. (9097776)
1995
42
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
43
Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. (8154531)
1994
44
Treatment of vernal keratoconjunctivitis: a retrospective clinical case study. Wallace F. Molinari Ocular Pharmacology Award. (1923330)
1991
45
Immunopathological study of vernal keratoconjunctivitis. (2673945)
1989
46
Vernal keratoconjunctivitis and trachoma. (3220668)
1988
47
Limbal vernal keratoconjunctivitis in the tropics. (3079119)
1988
48
A comparison between 2% and 4% sodium cromoglycate eye drops in the treatment of vernal keratoconjunctivitis. (6821197)
1982-1983
49
Randomized clinical trial of topically administered cromolyn sodium for vernal keratoconjunctivitis. (6775537)
1980
50
Cromolyn effects on vernal keratoconjunctivitis in children. (412489)
1977

Genetic Variations for Vernal Keratoconjunctivitis

Expression for genes affiliated with Vernal Keratoconjunctivitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for genes affiliated with Vernal Keratoconjunctivitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MMP8, MMP10, MMP13
2
Hide members
10.2MMP8, MMP10, MMP13
310.2CCL11, CXCL11, CXCL9
410.2CCL11, CCL17, IGHE
5
Hide members
10.1CMA1, MMP8, MMP10, MMP13
6
Immune response CCR3 signaling in eosinophils
Hide members
10.1CCL7, CCL8, CCL11, CCL24
7
Cell adhesion ECM remodeling
Hide members
10.0HBEGF, MMP13, MMP10, MMP8, CMA1
89.9CCL22, CCL11, CCL17, CCL7, CXCL11, CXCL9
9
Hide members
9.9CCL22, CCL11, CCL17, CCL7, CXCL11, CXCL9
10
Hide members
9.7CCL22, CCL24, CCL11, CCL1, CCL8, CCL17
11
Hide members
9.7CCL22, CCL11, CCL17, CCL7, ICAM3, HBEGF
12
Hide members
9.6CCL22, CCL24, CCL11, CCL1, CCL8, CCL17
13
Hide members
9.6CCL22, CCL24, CCL11, CCL1, CCL8, CCL17
14
Hide members
9.5CCL22, THPO, CXCL9, CXCL11, CCL7, CCL17
15
Hide members
9.5CXCL9, CXCL11, CCL7, CCL17, CCL8, CCL1
16
Hide members
9.4CCL22, CCL24, CCL11, CCL1, CCL8, CCL17
17
Hide members
9.2MMP8, CCL22, CCL24, CCL11, CCL1, CCL8

Compounds for genes affiliated with Vernal Keratoconjunctivitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1pge24510.7CCL11
2indomethacin45 60 29 1113.6PRG2
3unicap4510.6RNASE3, IGHE, CCL11
4anti-histamine4510.6RNASE3, IGHE, CCL11
5sodium cromoglycate4510.6CCL11, IGHE, RNASE3
6cetirizine45 29 11 2413.6CCL11, IGHE, RNASE3
7(4-aminophenyl)mercuric acetate4510.6MMP10, MMP8, MMP13
8larc4510.5CCL17, CCL22, CCL7
9ketotifen45 1111.5RNASE3, IGHE, CCL11
10uk 3833676010.5MMP13, MMP8, MMP10
11gm 60016010.5MMP8, MMP10, MMP13
12batimastat45 60 1112.5MMP13, MMP8, MMP10, HBEGF
13groalpha4510.5CXCL9, CCL7, CCL11, MMP13
14gi 254023x6010.5MMP8, MMP10, MMP13
15pgd24510.5PRG2, CCL11, IGHE, RNASE3
16leukotriene b445 60 2412.5CCL11, RNASE3, CCL7, CCL8, CCL22
17montelukast45 50 29 1113.4CCL11, RNASE3, IGHE
18methacholine45 1111.4CCL11, IGHE, PRG2, CCL22, RNASE3
19oxygen45 2411.4CCL7, PRG2, MMP8, MMP13, CCL11
20allergens4510.4RNASE3, PRG2, IGHE, CMA1, CCL17, CCL11
21matrigel4510.3HBEGF, CCL11, THPO, MMP10, MMP13
22latex4510.3HBEGF, IGHE, THPO, RNASE3
23marimastat45 60 1112.3MMP13, MMP10, MMP8
24p0024510.3MMP8, RNASE3, MMP13, THPO
25barbiturate4510.3MMP13, MMP8
26rantes4510.3CCL8, THPO, CXCL11, RNASE3, ICAM3, CCL7
27ltc44510.3PRG2, RNASE3, CCL11
28sb 20358045 6011.3MMP13, CCL22, THPO, CCL11, HBEGF
29fibrinogen4510.3THPO, CCL22, CCL17, HBEGF, MMP13, RNASE3
30cyclosporin a45 29 6012.3RNASE3, CXCL11, MMP8, IGHE, CCL17, CCL11
31prednisolone45 29 1112.3CCL11, IGHE, MMP13, RNASE3
32fmlp4510.2CCL11, CCL8, THPO, RNASE3, PRG2, ICAM3
33genistein45 29 60 2 11 2415.2PRG2, CCL11, CCL7, HBEGF, MMP13, MMP8
34fluticasone propionate45 50 60 1113.2CCL11, RNASE3, IGHE
35polysaccharide4510.2RNASE3, HBEGF, IGHE, ICAM3, THPO
36heparin45 29 11 2413.2CCL11, CMA1, MMP13, RNASE3, HBEGF, PRG2
37budesonide45 50 1112.1CCL11, IGHE, RNASE3
38actinomycin d4510.1CCL7, MMP13, IGHE, PRG2, HBEGF, THPO
39ccl445 2911.1MMP13, CXCL9, CXCL11, CCL7, CCL17, CCL8
40ccl345 2911.1CCL24, CCL22, CCL11, CCL1, CCL8, CCL17
41retinoic acid45 2411.0RNASE3, HBEGF, IGHE, PRG2, CCL11, THPO
42vegf4510.0MMP8, MMP13, THPO, MMP10, CCL11, IGHE
43histamine45 29 2412.0THPO, CMA1, CXCL9, IGHE, PRG2, CCL7
44tarc459.9CXCL9, CCL17, CCL7, IGHE, CXCL11, CCL8
45nitric oxide45 11 2411.9MMP8, THPO, MMP13, CCL17, HBEGF, CXCL9
46oligonucleotide459.9MMP10, MMP8, THPO, MMP13, CXCL11, CCL1
47salbutamol45 50 29 11 2413.9CCL11, IGHE, RNASE3
48tyrosine459.9MMP13, HBEGF, CCL8, THPO, CCL7, ICAM3
49dexamethasone45 50 29 1112.8RNASE3, CXCL9, CCL22, CXCL11, CCL11, MMP13
50calcium45 50 11 2412.2CMA1, THPO, MMP8, MMP10, MMP13, CCL22

GO Terms for genes affiliated with Vernal Keratoconjunctivitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.1MMP8, MMP10, MMP13, CRISP3
2extracellular spaceGO:0056159.1THPO, CCL22, CCL24, CCL11, CCL1, CCL8
3extracellular regionGO:0055768.8PRG2, CRISP3, CCL7, CCL17, CCL11, CCL22

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.4CCL7, CCL11, CCL24
2collagen catabolic processGO:03057410.4MMP13, MMP10, MMP8
3extracellular matrix disassemblyGO:02261710.3MMP13, MMP10, MMP8, CMA1
4positive regulation of angiogenesisGO:04576610.3CMA1, CCL11, CCL24
5cellular calcium ion homeostasisGO:00687410.3CCL11, CCL1, CCL8, CCL7
6positive regulation of Rac GTPase activityGO:03285510.3CCL11, CCL24
7positive regulation of cell migrationGO:03033510.3HBEGF, CCL7, CCL11, CCL24
8cytoskeleton organizationGO:00701010.2CCL24, CCL11, CCL7
9extracellular matrix organizationGO:03019810.2CMA1, MMP8, MMP10, MMP13
10regulation of cell shapeGO:00836010.1CCL7, CCL11, CCL24
11cell-cell signalingGO:00726710.1CCL22, CCL24, CCL8, CCL17, CCL7, CXCL11
12inflammatory responseGO:00695410.0CCL22, CCL24, CCL11, CCL8, CCL17, CCL7
13chemotaxisGO:0069359.9CXCL11, CCL7, CCL17, CCL8, CCL1, CCL11
14response to virusGO:0096159.9CCL8, CCL11, CCL22
15signal transductionGO:0071659.9CCL22, CCL24, CCL11, CCL1, CCL8, CCL7
16immune responseGO:0069559.7CXCL9, CCL22, CCL24, CXCL11, IGHE, PRG2

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.2MMP8, MMP10, MMP13
2heparin bindingGO:0082019.8CCL8, CCL7, PRG2, HBEGF
3chemokine activityGO:0080099.5CXCL9, CCL22, CCL24, CCL11, CCL1, CCL8

Products for genes affiliated with Vernal Keratoconjunctivitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vernal Keratoconjunctivitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet