VKC
MCID: VRN004
MIFTS: 51

Vernal Keratoconjunctivitis (VKC) malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

Aliases & Descriptions for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 50 56
Keratoconjunctivitis, Vernal 69
Keratoconjunctivitis Vernal 52
Spring Catarrh 56
Vkc 50

Characteristics:

Orphanet epidemiological data:

56
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA70476
UMLS via Orphanet 70 C0022577
ICD10 via Orphanet 34 H16.2

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 50 vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and conjunctivitis, and has symptoms including abnormality of the conjunctiva, abnormality of the sclera and photophobia. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and neutrophil, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 71 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 11.1
2 conjunctivitis 10.4
3 keratoconus 10.3
4 allergic conjunctivitis 10.3
5 restrictive cardiomyopathy 10.3 IL5 RNASE3
6 brown shrimp allergy 10.2 IL5 RNASE3
7 peptidic growth factors deficiency 10.2 CCL11 IL5
8 benign meningioma 10.2 IL5 RNASE3
9 papillary squamous carcinoma 10.2 IL4 IL5
10 psychotic disorder 10.2 CCL11 IL4
11 hypersensitivity vasculitis 10.2 IL4 IL5
12 retinal vascular disease 10.2 CCL11 IL4
13 allescheriosis 10.2 IL4 IL5
14 keratitis 10.2
15 ileocolitis 10.2 ICAM1 IL4
16 vulvar disease 10.2 CCL5 RNASE3
17 breast intracanalicular fibroadenoma 10.2 IL4 IL5
18 histoplasmosis retinitis 10.2 IL4 IL5
19 hidradenitis suppurativa 10.2 CCL11 CCL5
20 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2 ICAM1 IL4
21 appendix carcinoid tumor 10.2 MMP9 RNASE3
22 necrotizing gastritis 10.1 CCL11 IL5 RNASE3
23 hypotrichosis 4 10.1 ICAM1 IL4
24 sparganosis 10.1 ICAM1 IL4
25 marasmus 10.1 IL4 IL5 RNASE3
26 lens-induced iridocyclitis 10.1 IL4 IL5 RNASE3
27 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 IL4 IL5 RNASE3
28 familial renal papillary carcinoma 10.1 CCL11 IL5 RNASE3
29 monocytic leukemia 10.1 CCL11 IL5 RNASE3
30 orbit alveolar rhabdomyosarcoma 10.1 IL4 IL5 RNASE3
31 anterior dislocation of lens 10.1 CCL11 IL4 RNASE3
32 retinal artery occlusion 10.1 CCL11 MMP9
33 dislocation of ear ossicle 10.1 ICAM1 RNASE3
34 mycobacterium xenopi 10.1 CCL5 MMP9
35 isolated klippel-feil syndrome 10.1 IL4 IL5
36 neurotic disorder 10.1 ICAM1 IL4
37 infectious anterior uveitis 10.1 CCL5 IL5 RNASE3
38 dahlberg borer newcomer syndrome 10.1 IL13 IL5
39 atopic keratoconjunctivitis 10.1
40 atopy 10.1
41 chlamydia 10.1
42 spastic hemiplegia 10.1 ICAM1 MMP9
43 natural killer cell leukemia 10.1 CCL11 IL5 MMP9
44 aortic atherosclerosis 10.1 IL13 IL5
45 dissociated nystagmus 10.1 IL4 IL5
46 leukoplakia of penis 10.1 CCL5 IL4
47 bile duct signet ring cell carcinoma 10.1 IL5 RNASE3
48 urethral intrinsic sphincter deficiency 10.1 IL4 IL5 MMP9
49 hydrops of gallbladder 10.0 CCL5 IL4 IL5
50 isthmus cancer 10.0 CCL11 IL4 MMP9

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

56 32 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the conjunctiva 56 32 Very frequent (99-80%) HP:0000502
2 abnormality of the sclera 56 32 Very frequent (99-80%) HP:0000591
3 photophobia 56 32 Very frequent (99-80%) HP:0000613
4 lacrimation abnormality 56 32 Very frequent (99-80%) HP:0000632
5 pruritus 56 32 Very frequent (99-80%) HP:0000989
6 corneal neovascularization 56 32 Very frequent (99-80%) HP:0011496
7 punctate keratitis 56 32 Very frequent (99-80%) HP:0011859
8 allergy 56 32 Very frequent (99-80%) HP:0012393
9 scarring 56 32 Frequent (79-30%) HP:0100699
10 abnormality of the cornea 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 IL4 IL5 MMP9 CCL11 CCL5 CXCR3
2 digestive/alimentary MP:0005381 9.65 IL13 IL4 IL5 MMP9 ICAM1
3 immune system MP:0005387 9.56 IL4 IL5 MMP9 CCL11 CCL5 CXCR3
4 respiratory system MP:0005388 9.1 IL4 IL5 MMP9 CCL11 CXCR3 IL13

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
3
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
4
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
5
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
7
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
8
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
9 Dexamethasone acetate Phase 4 1177-87-3
10 glucocorticoids Phase 4
11
protease inhibitors Phase 4
12 N-acetyl-1-aspartylglutamic acid Phase 4
13 Nasal Decongestants Phase 4,Phase 3,Phase 2
14 Gastrointestinal Agents Phase 4
15 Neuroprotective Agents Phase 4
16 Neurotransmitter Agents Phase 4,Phase 3
17 HIV Protease Inhibitors Phase 4
18 Tetrahydrozoline Phase 4,Phase 3,Phase 2
19 Histamine Antagonists Phase 4,Phase 3
20 Histamine H1 Antagonists Phase 4,Phase 3
21 Dermatologic Agents Phase 4,Phase 3,Phase 2
22 Hormone Antagonists Phase 4
23 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
24 Dexamethasone 21-phosphate Phase 4
25 Hormones Phase 4
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
28 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
29 Anti-Allergic Agents Phase 4,Phase 3
30 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
31 Anti-Asthmatic Agents Phase 4
32 Anti-Infective Agents Phase 4,Phase 3,Phase 2
33 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
34 Protective Agents Phase 4
35 Antiemetics Phase 4
36 Anti-Inflammatory Agents Phase 4
37 Antifungal Agents Phase 4,Phase 3,Phase 2
38 Respiratory System Agents Phase 4,Phase 3,Phase 2
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2
40 BB 1101 Phase 4
41 Autonomic Agents Phase 4,Phase 3,Phase 2
42 Antineoplastic Agents, Hormonal Phase 4
43 Bronchodilator Agents Phase 4
44 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
45 Glutamic Acid Nutraceutical Phase 4
46
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
47 Antipruritics Phase 3
48 Acidophilus Nutraceutical Phase 2, Phase 3

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4
2 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4
3 Topical Tacrolimus in Vernal Keratoconjunctivitis Recruiting NCT02456025 Phase 4
4 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3
5 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3
6 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3
7 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3
8 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3
9 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3
10 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Active, not recruiting NCT01751126 Phase 3
11 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

39
Eye, Testes, Neutrophil, T Cells, Thyroid

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 317)
id Title Authors Year
1
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
2
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
3
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
4
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
5
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
6
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016
7
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
8
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
9
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
10
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
11
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
12
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
13
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
14
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
15
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
16
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
17
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
18
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
19
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
20
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
21
Intracellular IL-4, IL-5, and IFN-I^ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis. ( 25999672 )
2015
22
Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis. ( 26235361 )
2015
23
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? ( 25692810 )
2015
24
Topographic corneal changes in children with vernal keratoconjunctivitis: A report from Kathmandu, Nepal. ( 26070227 )
2015
25
Corneal complications of vernal keratoconjunctivitis. ( 26258926 )
2015
26
Dry Eye in Vernal Keratoconjunctivitis: A Cross-Sectional Comparative Study. ( 26496269 )
2015
27
Deep Anterior Lamellar Keratoplasty in Keratoconic Patients with versus without Vernal Keratoconjunctivitis. ( 26425311 )
2015
28
Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. ( 25712437 )
2015
29
[Vernal keratoconjunctivitis]. ( 26464371 )
2015
30
Is there is an association between the presence of Staphylococcus species and occurrence of vernal keratoconjunctivitis? ( 26586974 )
2015
31
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. ( 26768065 )
2015
32
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis. ( 25756057 )
2015
33
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics. ( 25744396 )
2015
34
In vivo confocal microscopy of meibomian glands and palpebral conjunctiva in vernal keratoconjunctivitis. ( 26044472 )
2015
35
Topical Tacrolimus 0.03% as Sole Therapy in Vernal Keratoconjunctivitis: A Randomized Double-Masked Study. ( 24418865 )
2014
36
Effect of Vernal Keratoconjunctivitis on Vitreous Depth in Patients with Keratoconus. ( 24409941 )
2014
37
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. ( 25140177 )
2014
38
CCL20/MIP-3 alpha mRNA expression in the conjunctival epithelium of normal individuals and patients with vernal keratoconjunctivitis. ( 25172034 )
2014
39
Alpha-1 antitrypsin, a diagnostic and prognostic marker of vernal keratoconjunctivitis. ( 24995171 )
2014
40
A double blind clinical trial on the efficacy of honey drop in vernal keratoconjunctivitis. ( 24707307 )
2014
41
Pathogenesis of Vernal Keratoconjunctivitis and Associated Factors. ( 24571721 )
2014
42
Vernal keratoconjunctivitis: a severe allergic eye disease with remodeling changes. ( 24438133 )
2014
43
Efficacy of topical 0.05% cyclosporine treatment in children with severe vernal keratoconjunctivitis. ( 25818961 )
2014
44
Images in clinical medicine. Giant papillae in vernal keratoconjunctivitis. ( 24758619 )
2014
45
Immunogenetic investigation in vernal keratoconjunctivitis. ( 24899226 )
2014
46
Topical cyclosporine a 0.05% eyedrops in the treatment of vernal keratoconjunctivitis - randomized placebo-controlled trial. ( 24979519 )
2014
47
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. ( 25410033 )
2014
48
Vernal keratoconjunctivitis with giant papillae on the inferior tarsal conjunctiva. ( 24240487 )
2014
49
Limbal pseudoepitheliomatous hyperplasia mimicking ocular surface squamous neoplasia in palpebral vernal keratoconjunctivitis. ( 23840996 )
2013
50
Evaluation of retinal nerve fiber layer thickness in vernal keratoconjunctivitis patients under long-term topical corticosteroid therapy. ( 24021018 )
2013

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.45 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.33 CCL11 CCL5 ICAM1 IL13 IL4 IL5
4
Show member pathways
13.2 CCL11 CCL5 CXCR3 ICAM1 MMP9
5
Show member pathways
13.2 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.15 CCL11 CCL5 ICAM1 IL13 IL4 IL5
7
Show member pathways
13.09 CCL11 CCL5 CXCR3 IL13 IL4 IL5
8
Show member pathways
12.62 CCL5 ICAM1 IL13 IL4
9
Show member pathways
12.62 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10
Show member pathways
12.17 CCL11 CCL5 ICAM1
11
Show member pathways
12.16 CCL5 ICAM1 IL4
12
Show member pathways
12.1 CCL11 IL13 IL4 IL5 MMP9
13
Show member pathways
12.05 IL13 IL4 IL5
14
Show member pathways
12 IL13 IL4 IL5
15
Show member pathways
11.87 CCL11 CCL5 CXCR3
16 11.85 ICAM1 IL4 MMP9
17 11.8 CCL5 ICAM1 MMP9
18 11.67 ICAM1 IL13 IL4 IL5
19 11.64 CXCR3 IL13 IL4 IL5
20 11.59 ICAM1 IL4 IL5
21 11.53 CCL11 IL4 IL5
22 11.41 CCL11 ICAM1 IL13 IL4 MMP9
23 11.26 CCL5 MMP9
24 11.25 CCL5 ICAM1 IL13 IL4
25 11.22 IL13 IL4 IL5
26 11.19 CCL11 CXCR3
27 11.18 IL4 IL5
28 11.18 IL13 IL4 IL5
29 11.14 CCL5 MMP9
30 11.13 CCL11 IL13 IL4 IL5
31 11.1 IL13 IL4 IL5
32 11.04 ICAM1 MMP9
33 10.95 CCL11 CCL5 IL13 IL4 IL5
34 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
35 10.85 CCL5 MMP9
36 10.83 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 external side of plasma membrane GO:0009897 9.26 CXCR3 ICAM1 IL13 IL4
3 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.91 CCL11 CCL5 ICAM1 IL5
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 CCL11 CCL5 ICAM1
3 positive regulation of cell migration GO:0030335 9.77 CCL11 CCL5 MMP9
4 response to ethanol GO:0045471 9.73 ICAM1 IL13 IL4
5 cellular response to tumor necrosis factor GO:0071356 9.72 CCL11 CCL5 ICAM1
6 immune response GO:0006955 9.72 CCL11 CCL5 IL13 IL4 IL5
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 ICAM1 IL4 IL5
8 cellular response to interleukin-1 GO:0071347 9.65 CCL11 CCL5 ICAM1
9 chemokine-mediated signaling pathway GO:0070098 9.63 CCL11 CCL5 CXCR3
10 monocyte chemotaxis GO:0002548 9.62 CCL11 CCL5
11 leukocyte cell-cell adhesion GO:0007159 9.61 CCL5 ICAM1
12 cellular response to interferon-gamma GO:0071346 9.61 CCL11 CCL5 ICAM1
13 innate immune response in mucosa GO:0002227 9.58 IL4 RNASE3
14 positive regulation of JAK-STAT cascade GO:0046427 9.58 CCL5 IL5
15 microglial cell activation GO:0001774 9.57 IL13 IL4
16 positive regulation of mast cell degranulation GO:0043306 9.54 IL13 IL4
17 eosinophil chemotaxis GO:0048245 9.52 CCL11 CCL5
18 positive regulation of immunoglobulin production GO:0002639 9.49 IL13 IL4
19 chemotaxis GO:0006935 9.46 CCL11 CCL5 CXCR3 IL4
20 positive regulation of B cell proliferation GO:0030890 9.43 IL13 IL4 IL5
21 regulation of proton transport GO:0010155 9.4 IL13 IL4
22 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
23 inflammatory response GO:0006954 9.35 CCL11 CCL5 CXCR3 IL13 IL5
24 negative regulation of endothelial cell apoptotic process GO:2000352 8.8 ICAM1 IL13 IL4

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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