VKC
MCID: VRN004
MIFTS: 47

Vernal Keratoconjunctivitis (VKC) malady

Rare diseases, Eye diseases categories

Summaries for Vernal Keratoconjunctivitis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards: Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is CMA1 (chymase 1, mast cell), and among its related pathways are CXCR3-mediated signaling events and Immune response Bacterial infections in normal airways. The compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related mouse phenotype immune system.

Wikipedia:66 Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting... more...

Aliases & Classifications for Vernal Keratoconjunctivitis

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44NIH Rare Diseases, 50Orphanet, 46Novoseek, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 50 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

50
vernal keratoconjunctivitis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

vernal keratoconjunctivitis 44 50
keratoconjunctivitis, vernal 63
keratoconjunctivitis vernal 46
spring catarrh 50
vkc 44


External Ids:

ICD10 via Orphanet27 H16.2
SNOMED-CT via Orphanet60 317349009
UMLS via Orphanet64 C0022577

Related Diseases for Vernal Keratoconjunctivitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.2RNASE3, CCL11
2conjunctivitis31.2RNASE3
3allergic conjunctivitis31.0CCL11, RNASE3
4giant papillary conjunctivitis30.6RNASE3, CCL11
5atopy30.6RNASE3, CMA1, CCL17, CCL22, CCL11
6eosinophilia30.5RNASE3, CCL17, CCL7, CCL11
7allergic rhinitis30.4CCL11, RNASE3
8uveitis30.4CCL11, CXCL11
9asthma30.3RNASE3, CMA1, CCL17, CCL7, CCL22, CCL11
10rhinitis30.2RNASE3, CMA1, CCL7, CCL11
11atopic dermatitis30.2CCL11, CCL22, CCL17, RNASE3
12dermatitis30.2CCL11, CCL22, CCL17, CXCL11, CMA1
13allergic asthma30.2RNASE3, CMA1, CCL17, CCL7, CCL11
14keratoconus10.7
15keratitis10.5
16blindness10.4
17trachoma10.4
18conjunctival pigmentation10.4
19glaucoma10.4
20papillary conjunctivitis10.4
21atopic keratoconjunctivitis10.4
22porphyria10.2
23congenital porphyria10.2
24graft versus host disease10.2
25limbal stem cell deficiency10.2
26corneal ectasia10.2
27vernal conjunctivitis10.2
28ocular hypertension10.2
29mooren's ulcer10.2
30amblyopia10.2
31conjunctival deposit10.2
32corneal deposit10.2
33corneal ulcer10.2
34eye disease10.2
35hypertension10.2
36retinitis10.2
37steroid-induced glaucoma10.2
38anterior uveitis10.2
39paragonimiasis10.1CCL17
40urticaria10.1RNASE3
41chronic eosinophilic pneumonia10.1CCL11, RNASE3
42common cold10.0CCL11, RNASE3
43pulmonary eosinophilia10.0CCL11, RNASE3
44food allergy10.0CCL11, RNASE3
45hypereosinophilic syndrome10.0CCL11, RNASE3
46otitis media10.0CCL11, RNASE3
47sinusitis10.0CCL11, RNASE3
48bronchitis10.0CCL11, RNASE3
49pemphigus vulgaris10.0CCL17, CCL11
50encephalomyelitis10.0CCL7

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to vernal keratoconjunctivitis

Symptoms for Vernal Keratoconjunctivitis

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Drugs & Therapeutics for Vernal Keratoconjunctivitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vernal Keratoconjunctivitis

Drug clinical trials:

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Search NIH Clinical Center for Vernal Keratoconjunctivitis

Search CenterWatch for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

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Anatomical Context for Vernal Keratoconjunctivitis

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34MalaCards
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MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

34
Eye, Testes

Animal Models for Vernal Keratoconjunctivitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CCL11, CCL7, CCL17, MMP10, CMA1

Publications for Vernal Keratoconjunctivitis

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Sources:
53PubMed
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Articles related to Vernal Keratoconjunctivitis:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Vernal keratoconjunctivitis with giant papillae on the inferior tarsal conjunctiva. (24240487)
2014
2
Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. (23625179)
2013
3
Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab. (23607979)
2013
4
Vernal keratoconjunctivitis: an update. (23038763)
2013
5
Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis. (22927736)
2012
6
Fluid-filled scleral contact lenses in vernal keratoconjunctivitis. (22367220)
2012
7
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
8
In vivo laser scanning confocal microscopy of vernal keratoconjunctivitis. (20662846)
2011
9
Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey. (21976577)
2011
10
Vernal keratoconjunctivitis with limbal stem cell deficiency. (21598432)
2011
11
Treatment of severe vernal keratoconjunctivitis with 1% topical cyclosporine in an Italian cohort of 197 children. (19840298)
2010
12
Tailored approach to the treatment of vernal keratoconjunctivitis. (20382430)
2010
13
Vernal keratoconjunctivitis: a major review. (18786127)
2009
14
Perilimbal conjunctival pigmentation in Chinese patients with vernal keratoconjunctivitis. (17464306)
2008
15
Vernal keratoconjunctivitis at Guinness Eye Centre, Luth (a five year study). (19062462)
2008
16
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
17
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
18
Vernal keratoconjunctivitis presenting unilaterally. (16761642)
2006
19
Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis. (15629970)
2005
20
Topical cyclosporine 0.5 per cent and preservative-free ketorolac tromethamine 0.5 per cent in vernal keratoconjunctivitis. (15061303)
2004
21
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
22
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
23
Vernal keratoconjunctivitis in Nigerians: 109 consecutive cases. (14620434)
2003
24
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
25
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
26
Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. (12234902)
2002
27
Surgical treatment of limbal vernal keratoconjunctivitis by resection of a limbal lesion. (12543198)
2002
28
Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80). (11702979)
2001
29
Expression of chemokine receptors in vernal keratoconjunctivitis. (11673306)
2001
30
Cyclosporine effects on clinical findings and impression cytology specimens in severe vernal keratoconjunctivitis. (11399937)
2001
31
Combined medical and surgical treatment of severe vernal keratoconjunctivitis. (11033129)
2000
32
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
33
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
34
Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: a flow-cytometric study. (9483586)
1998
35
Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. (9683957)
1998
36
Topical cyclosporin A 2% in the treatment of vernal keratoconjunctivitis. (9246280)
1997
37
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
38
IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)
1995
39
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (7657550)
1995
40
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
41
Lodoxamide for vernal keratoconjunctivitis. (8121328)
1994
42
Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. (8154531)
1994
43
Treatment of vernal keratoconjunctivitis a double-masked study. (22822779)
1993
44
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
45
Frequency of chlamydia in patients with vernal keratoconjunctivitis. (2488657)
1989
46
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
47
Corneal ectasia in vernal keratoconjunctivitis. (2616147)
1989
48
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
49
A comparison between 2% and 4% sodium cromoglycate eye drops in the treatment of vernal keratoconjunctivitis. (6821197)
1982-1983
50
Vernal keratoconjunctivitis in an Israeli group of patients and its treatment with sodium cromoglycate. (6800400)
1982

Variations for Vernal Keratoconjunctivitis

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Expression for genes affiliated with Vernal Keratoconjunctivitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for genes affiliated with Vernal Keratoconjunctivitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 56Reactome, 13EMD Millipore, 55R&D Systems, 31KEGG
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Pathways related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL11, CXCL11
2
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.6CCL11, CXCL11
39.5CCL11, CCL17
4
Show member pathways
9.3CMA1, MMP10
5
Show member pathways
9.3MMP10, CMA1
6
Show member pathways
8.4CCL11, CCL22, CCL7, CCL17
7
Show member pathways
8.0CCL11, CCL22, CCL7, CCL17, CXCL11
8
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
9
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
10
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
11
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
12
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
13
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
14
Show member pathways
7.6CMA1, CXCL11, CCL17, CCL7, CCL22, CCL11
15
Show member pathways
7.2MMP10, CXCL11, CCL17, CCL7, CCL22, CCL11

Compounds for genes affiliated with Vernal Keratoconjunctivitis

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1unicap469.9RNASE3, CCL11
2anti-histamine469.9CCL11, RNASE3
3lte4469.9CCL11, RNASE3
4sodium cromoglycate469.9CCL11, RNASE3
5cetirizine46 30 25 1212.9RNASE3, CCL11
6pranlukast46 30 1211.9CCL11, RNASE3
7ketotifen46 1210.9CCL11, RNASE3
8salmeterol46 52 30 1212.9CCL11, RNASE3
9roxithromycin46 30 1211.9CCL17, CCL11
10montelukast46 52 30 1212.8CCL11, RNASE3
11ltc4469.8RNASE3, CCL11
12budesonide46 52 1211.8RNASE3, CCL11
13fluticasone propionate46 52 62 1212.8CCL11, RNASE3
14salbutamol46 52 30 25 1213.7CCL11, RNASE3
15capsaicin46 3010.7RNASE3, CMA1
16pgd2469.7CCL11, RNASE3
17anaphylatoxin469.7CCL7, RNASE3
18n-formylmethionyl-leucylphenylalanine469.6CCL11, RNASE3
19groalpha469.6CCL11, CCL7
20pertussis469.6CCL22, CCL11
21prednisolone46 30 1211.5CCL11, RNASE3
22methacholine46 52 1211.4CCL11, CCL22, RNASE3
23fibrinogen469.4CCL22, CCL17, RNASE3
24aspirin46 52 30 2512.3RNASE3, CCL22, CCL11
25tacrolimus46 52 1211.3CCL17, CCL22, CCL11
26fmlp469.3CCL11, CCL7, RNASE3
27larc469.3CCL22, CCL7, CCL17
28dithiothreitol469.2CCL11, RNASE3
29allergens469.2CCL11, CCL17, CMA1, RNASE3
30pge2469.1CCL11, CCL22, RNASE3
31heparin46 30 25 1212.1CCL11, CMA1, RNASE3
32leukotriene b446 62 2510.8CCL11, CCL22, CCL7, RNASE3
33adp46 30 2510.8CCL22, CCL7, CCL17, RNASE3
34cyclosporin a46 30 6210.6RNASE3, CXCL11, CCL17, CCL22, CCL11
35histamine46 30 2510.5RNASE3, CMA1, CCL7, CCL22, CCL11
36tarc468.4CCL11, CCL22, CCL7, CCL17, CXCL11
37ccl346 309.4CXCL11, CCL17, CCL7, CCL22, CCL11
38ccl446 309.4CXCL11, CCL17, CCL7, CCL22, CCL11
39oligonucleotide468.1RNASE3, MMP10, CXCL11, CCL7, CCL22
40rantes468.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
41dexamethasone46 52 30 1211.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
42calcium46 52 25 129.8RNASE3, CMA1, MMP10, CXCL11, CCL17, CCL7

GO Terms for genes affiliated with Vernal Keratoconjunctivitis

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17Gene Ontology
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Cellular components related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.2CCL11, CCL22, CCL7, CCL17, CXCL11, MMP10
2extracellular regionGO:0055766.1CCL11, RNASE3, CMA1, MMP10, CXCL11, CCL17

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:0457669.7CMA1, CCL11
2cell chemotaxisGO:0603269.6CCL17, CCL22
3eosinophil chemotaxisGO:0482459.5CCL7, CCL11
4cellular calcium ion homeostasisGO:0068749.4CCL11, CCL7
5response to virusGO:0096159.4CCL11, CCL22
6cytoskeleton organizationGO:0070109.3CCL11, CCL7
7regulation of cell shapeGO:0083609.2CCL11, CCL7
8extracellular matrix disassemblyGO:0226179.0MMP10, CMA1
9cell-cell signalingGO:0072678.7CCL22, CCL7, CCL17, CXCL11
10signal transductionGO:0071658.6CCL11, CCL22, CCL7, CXCL11
11chemotaxisGO:0069358.2CCL11, CCL22, CCL7, CCL17, CXCL11
12inflammatory responseGO:0069548.2CXCL11, CCL17, CCL7, CCL22, CCL11
13immune responseGO:0069558.2CXCL11, CCL17, CCL7, CCL22, CCL11

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080098.0CCL11, CCL22, CCL7, CCL17, CXCL11

Products for genes affiliated with Vernal Keratoconjunctivitis

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Sources for Vernal Keratoconjunctivitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet