VKC
MCID: VRN004
MIFTS: 47

Vernal Keratoconjunctivitis (VKC) malady

Rare diseases, Eye diseases categories
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Summaries for Vernal Keratoconjunctivitis

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NIH Rare Diseases:42 Vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards based summary: Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is CMA1 (chymase 1, mast cell), and among its related pathways are CXCR3-mediated signaling events and Immune response Bacterial infections in normal airways. The compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related mouse phenotype immune system.

Wikipedia:65 Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting... more...

Aliases & Classifications for Vernal Keratoconjunctivitis

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Sources:
42NIH Rare Diseases, 48Orphanet, 44Novoseek, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Vernal Keratoconjunctivitis, Aliases & Descriptions:

Name: Vernal Keratoconjunctivitis 42 48
Keratoconjunctivitis, Vernal 62
Keratoconjunctivitis Vernal 44
 
Spring Catarrh 48
Vkc 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
vernal keratoconjunctivitis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Normal


External Ids:

ICD10 via Orphanet26 H16.2
UMLS via Orphanet63 C0022577

Related Diseases for Vernal Keratoconjunctivitis

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Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.6RNASE3, CCL11
2conjunctivitis31.7RNASE3
3allergic conjunctivitis31.3CCL11, RNASE3
4giant papillary conjunctivitis30.9RNASE3, CCL11
5allergic rhinitis30.6CCL11, RNASE3
6uveitis30.5CCL11, CXCL11
7eosinophilia30.2RNASE3, CCL17, CCL7, CCL11
8atopy30.2RNASE3, CMA1, CCL17, CCL22, CCL11
9rhinitis30.1RNASE3, CMA1, CCL7, CCL11
10atopic dermatitis30.1CCL11, CCL22, CCL17, RNASE3
11dermatitis29.9CCL11, CCL22, CCL17, CXCL11, CMA1
12allergic asthma29.8RNASE3, CMA1, CCL17, CCL7, CCL11
13asthma29.7RNASE3, CMA1, CCL17, CCL7, CCL22, CCL11
14keratoconus10.7
15keratitis10.6
16blindness10.5
17paragonimiasis10.4CCL17
18conjunctival pigmentation10.4
19trachoma10.4
20eye disease10.4
21papillary conjunctivitis10.4
22atopic keratoconjunctivitis10.4
23urticaria10.3RNASE3
24chronic eosinophilic pneumonia10.2CCL11, RNASE3
25graft versus host disease10.2
26hypertension10.2
27limbal stem cell deficiency10.2
28vernal conjunctivitis10.2
29corneal ectasia10.2
30ocular hypertension10.2
31mooren's ulcer10.2
32amblyopia10.2
33conjunctival deposit10.2
34corneal deposit10.2
35corneal ulcer10.2
36retinitis10.2
37steroid-induced glaucoma10.2
38thyroiditis10.2
39anterior uveitis10.2
40common cold10.2CCL11, RNASE3
41pulmonary eosinophilia10.2CCL11, RNASE3
42food allergy10.2CCL11, RNASE3
43hypereosinophilic syndrome10.2CCL11, RNASE3
44otitis media10.2CCL11, RNASE3
45sinusitis10.2CCL11, RNASE3
46bronchitis10.2CCL11, RNASE3
47pemphigus vulgaris10.2CCL17, CCL11
48bronchiolitis10.1CCL11, RNASE3
49interstitial lung disease10.1CCL11, CCL17
50chronic obstructive pulmonary disease10.1CCL11, RNASE3

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to vernal keratoconjunctivitis

Symptoms for Vernal Keratoconjunctivitis

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Drugs & Therapeutics for Vernal Keratoconjunctivitis

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Drug clinical trials:

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Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

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Anatomical Context for Vernal Keratoconjunctivitis

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MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

32
Eye, Testes, Thyroid, Neutrophil

Animal Models for Vernal Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CCL11, CCL7, CCL17, MMP10, CMA1

Publications for Vernal Keratoconjunctivitis

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Articles related to Vernal Keratoconjunctivitis:

(show top 50)    (show all 279)
idTitleAuthorsYear
1
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. (25140177)
2014
2
CCL20/MIP-3 alpha mRNA expression in the conjunctival epithelium of normal individuals and patients with vernal keratoconjunctivitis. (25172034)
2014
3
Surgical resection and amniotic membrane transplantation for treatment of refractory giant papillae in vernal keratoconjunctivitis. (23086371)
2013
4
Management of vernal keratoconjunctivitis. (25135808)
2013
5
Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. (23625179)
2013
6
Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab. (23607979)
2013
7
Vernal keratoconjunctivitis: an update. (23038763)
2013
8
Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis. (22927736)
2012
9
Fluid-filled scleral contact lenses in vernal keratoconjunctivitis. (22367220)
2012
10
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
11
In vivo laser scanning confocal microscopy of vernal keratoconjunctivitis. (20662846)
2011
12
Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey. (21976577)
2011
13
Treatment of severe vernal keratoconjunctivitis with 1% topical cyclosporine in an Italian cohort of 197 children. (19840298)
2010
14
Tailored approach to the treatment of vernal keratoconjunctivitis. (20382430)
2010
15
Vernal keratoconjunctivitis: a major review. (18786127)
2009
16
Perilimbal conjunctival pigmentation in Chinese patients with vernal keratoconjunctivitis. (17464306)
2008
17
Vernal keratoconjunctivitis at Guinness Eye Centre, Luth (a five year study). (19062462)
2008
18
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
19
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
20
Vernal keratoconjunctivitis presenting unilaterally. (16761642)
2006
21
Topical cyclosporine 0.5 per cent and preservative-free ketorolac tromethamine 0.5 per cent in vernal keratoconjunctivitis. (15061303)
2004
22
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
23
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
24
Vernal keratoconjunctivitis in Nigerians: 109 consecutive cases. (14620434)
2003
25
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
26
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
27
Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. (12234902)
2002
28
Surgical treatment of limbal vernal keratoconjunctivitis by resection of a limbal lesion. (12543198)
2002
29
Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80). (11702979)
2001
30
Expression of chemokine receptors in vernal keratoconjunctivitis. (11673306)
2001
31
Cyclosporine effects on clinical findings and impression cytology specimens in severe vernal keratoconjunctivitis. (11399937)
2001
32
Combined medical and surgical treatment of severe vernal keratoconjunctivitis. (11033129)
2000
33
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
34
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
35
Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: a flow-cytometric study. (9483586)
1998
36
Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. (9683957)
1998
37
Topical cyclosporin A 2% in the treatment of vernal keratoconjunctivitis. (9246280)
1997
38
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
39
IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)
1995
40
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (7657550)
1995
41
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
42
Lodoxamide for vernal keratoconjunctivitis. (8121328)
1994
43
Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. (8154531)
1994
44
Treatment of vernal keratoconjunctivitis a double-masked study. (22822779)
1993
45
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
46
Frequency of chlamydia in patients with vernal keratoconjunctivitis. (2488657)
1989
47
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
48
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
49
A comparison between 2% and 4% sodium cromoglycate eye drops in the treatment of vernal keratoconjunctivitis. (6821197)
1982-1983
50
Vernal keratoconjunctivitis in an Israeli group of patients and its treatment with sodium cromoglycate. (6800400)
1982

Variations for Vernal Keratoconjunctivitis

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Expression for genes affiliated with Vernal Keratoconjunctivitis

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Expression patterns in normal tissues for genes affiliated with Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for genes affiliated with Vernal Keratoconjunctivitis

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Pathways related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL11, CXCL11
2
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.6CCL11, CXCL11
39.5CCL11, CCL17
4
Show member pathways
9.3CMA1, MMP10
5
Show member pathways
9.3MMP10, CMA1
6
Show member pathways
8.4CCL11, CCL22, CCL7, CCL17
7
Show member pathways
8.0CCL11, CCL22, CCL7, CCL17, CXCL11
8
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
9
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
10
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
11
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
12
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
13
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
14
Show member pathways
7.6CMA1, CXCL11, CCL17, CCL7, CCL22, CCL11
15
Show member pathways
7.2MMP10, CXCL11, CCL17, CCL7, CCL22, CCL11

Compounds for genes affiliated with Vernal Keratoconjunctivitis

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Compounds related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1unicap449.9RNASE3, CCL11
2anti-histamine449.9CCL11, RNASE3
3lte4449.9CCL11, RNASE3
4sodium cromoglycate449.9CCL11, RNASE3
5cetirizine44 28 24 1112.9RNASE3, CCL11
6pranlukast44 28 1111.9CCL11, RNASE3
7ketotifen44 1110.9CCL11, RNASE3
8salmeterol44 50 28 1112.9CCL11, RNASE3
9roxithromycin44 28 1111.9CCL17, CCL11
10montelukast44 50 28 1112.8CCL11, RNASE3
11ltc4449.8RNASE3, CCL11
12budesonide44 50 1111.8RNASE3, CCL11
13fluticasone propionate44 50 61 1112.8CCL11, RNASE3
14salbutamol44 50 28 24 1113.7CCL11, RNASE3
15capsaicin44 2810.7RNASE3, CMA1
16pgd2449.7CCL11, RNASE3
17anaphylatoxin449.7CCL7, RNASE3
18n-formylmethionyl-leucylphenylalanine449.6CCL11, RNASE3
19groalpha449.6CCL11, CCL7
20pertussis449.6CCL22, CCL11
21prednisolone44 28 1111.5CCL11, RNASE3
22methacholine44 50 1111.4CCL11, CCL22, RNASE3
23fibrinogen449.4CCL22, CCL17, RNASE3
24aspirin44 50 28 2412.3RNASE3, CCL22, CCL11
25tacrolimus44 50 1111.3CCL17, CCL22, CCL11
26fmlp449.3CCL11, CCL7, RNASE3
27larc449.3CCL22, CCL7, CCL17
28dithiothreitol449.2CCL11, RNASE3
29allergens449.2CCL11, CCL17, CMA1, RNASE3
30pge2449.1CCL11, CCL22, RNASE3
31heparin44 28 24 1112.1CCL11, CMA1, RNASE3
32leukotriene b444 61 2410.8CCL11, CCL22, CCL7, RNASE3
33adp44 28 2410.8CCL22, CCL7, CCL17, RNASE3
34cyclosporin a44 28 6110.6RNASE3, CXCL11, CCL17, CCL22, CCL11
35histamine44 28 2410.5RNASE3, CMA1, CCL7, CCL22, CCL11
36tarc448.4CCL11, CCL22, CCL7, CCL17, CXCL11
37ccl344 289.4CXCL11, CCL17, CCL7, CCL22, CCL11
38ccl444 289.4CXCL11, CCL17, CCL7, CCL22, CCL11
39oligonucleotide448.1RNASE3, MMP10, CXCL11, CCL7, CCL22
40rantes448.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
41dexamethasone44 50 28 1111.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
42calcium44 50 24 119.8RNASE3, CMA1, MMP10, CXCL11, CCL17, CCL7

GO Terms for genes affiliated with Vernal Keratoconjunctivitis

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Cellular components related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.2CCL11, CCL22, CCL7, CCL17, CXCL11, MMP10
2extracellular regionGO:0055766.1CCL11, RNASE3, CMA1, MMP10, CXCL11, CCL17

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:0457669.7CMA1, CCL11
2cell chemotaxisGO:0603269.6CCL17, CCL22
3eosinophil chemotaxisGO:0482459.5CCL7, CCL11
4cellular calcium ion homeostasisGO:0068749.4CCL11, CCL7
5response to virusGO:0096159.4CCL11, CCL22
6cytoskeleton organizationGO:0070109.3CCL11, CCL7
7regulation of cell shapeGO:0083609.2CCL11, CCL7
8extracellular matrix disassemblyGO:0226179.0MMP10, CMA1
9cell-cell signalingGO:0072678.7CCL22, CCL7, CCL17, CXCL11
10signal transductionGO:0071658.6CCL11, CCL22, CCL7, CXCL11
11chemotaxisGO:0069358.2CCL11, CCL22, CCL7, CCL17, CXCL11
12inflammatory responseGO:0069548.2CXCL11, CCL17, CCL7, CCL22, CCL11
13immune responseGO:0069558.2CXCL11, CCL17, CCL7, CCL22, CCL11

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080098.0CCL11, CCL22, CCL7, CCL17, CXCL11

Products for genes affiliated with Vernal Keratoconjunctivitis

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Sources for Vernal Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet