MCID: VRN004
MIFTS: 56

Vernal Keratoconjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 49 55
Keratoconjunctivitis, Vernal 69
Keratoconjunctivitis Vernal 51
Spring Catarrh 55
Vkc 49

Characteristics:

Orphanet epidemiological data:

55
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Orphanet 55 ORPHA70476
UMLS via Orphanet 70 C0022577
ICD10 via Orphanet 33 H16.2
UMLS 69 C0022577

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 49 Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition. Last updated: 12/7/2011

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to papillary conjunctivitis and giant papillary conjunctivitis, and has symptoms including abnormality of the conjunctiva, photophobia and lacrimation abnormality. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tacrolimus and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and neutrophil, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 72 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 papillary conjunctivitis 30.6 CCL11 IL4
2 giant papillary conjunctivitis 30.6 CCL11 IL4
3 atopic keratoconjunctivitis 30.5 IL4 IL5 RNASE3
4 keratoconjunctivitis 30.2 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
5 corneal ulcer 30.2 CCL11 MMP9
6 uveitis 29.6 CXCR3 ICAM1 IL4
7 ige responsiveness, atopic 29.6 IL13 IL4 IL5 RNASE3
8 conjunctivitis 29.1 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
9 allergic conjunctivitis 29.0 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 dermatitis 28.8 CCL11 IL13 IL4 IL5 RNASE3
11 allergic rhinitis 28.3 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
12 allergic asthma 28.3 CCL11 CCL5 IL13 IL4 IL5 RNASE3
13 allergic hypersensitivity disease 28.3 CCL11 CCL5 IL13 IL4 IL5 RNASE3
14 rhinitis 27.8 CCL11 CCL5 ICAM1 IL13 IL4 IL5
15 asthma 27.4 CCL11 CCL5 ICAM1 IL13 IL4 IL5
16 dermatitis, atopic 27.1 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
17 keratoconus 10.4
18 loeffler endocarditis 10.4 IL5 RNASE3
19 cow milk allergy 10.4 IL5 RNASE3
20 pemphigoid gestationis 10.4 CCL11 IL5
21 sinusitis 10.4 IL5 RNASE3
22 cellulitis 10.4 IL5 RNASE3
23 egg allergy 10.3 IL4 IL5
24 trichinosis 10.3 IL4 IL5
25 non-suppurative otitis media 10.3 IL4 IL5
26 cercarial dermatitis 10.3 IL4 IL5
27 keratitis, hereditary 10.3
28 toxic oil syndrome 10.3 IL4 IL5
29 wells syndrome 10.3 IL5 RNASE3
30 primary amebic meningoencephalitis 10.3 IL4 IL5
31 churg-strauss syndrome 10.3 IL5 RNASE3
32 maxillary sinusitis 10.3 CCL5 RNASE3
33 diversion colitis 10.3 ICAM1 IL4
34 henoch-schoenlein purpura 10.3 ICAM1 RNASE3
35 conjunctival nevus 10.3 MMP9 RNASE3
36 allergic bronchopulmonary aspergillosis 10.3 IL4 IL5
37 vulvovaginitis 10.3 CCL11 CCL5
38 poliomyelitis 10.2 ICAM1 IL4
39 bardet-biedl syndrome 15 10.2 ICAM1 IL4
40 eosinophilic gastroenteritis 10.2 CCL11 IL5 RNASE3
41 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
42 chlamydia 10.2
43 bronchitis 10.2 CCL11 IL5 RNASE3
44 cough variant asthma 10.2 IL4 IL5 RNASE3
45 intrinsic asthma 10.2 IL4 IL5 RNASE3
46 bullous pemphigoid 10.2 CCL11 IL5 RNASE3
47 milk allergy 10.2 IL4 IL5 RNASE3
48 blepharoconjunctivitis 10.2 CCL11 IL4 RNASE3
49 genital herpes 10.1 CCL5 IL4
50 yellow fever 10.1 CCL5 IL5

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

55 31 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the conjunctiva 55 31 hallmark (90%) Very frequent (99-80%) HP:0000502
2 photophobia 55 31 hallmark (90%) Very frequent (99-80%) HP:0000613
3 lacrimation abnormality 55 31 hallmark (90%) Very frequent (99-80%) HP:0000632
4 pruritus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000989
5 corneal neovascularization 55 31 hallmark (90%) Very frequent (99-80%) HP:0011496
6 punctate keratitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0011859
7 allergy 55 31 hallmark (90%) Very frequent (99-80%) HP:0012393
8 scarring 55 31 frequent (33%) Frequent (79-30%) HP:0100699
9 abnormality of the cornea 55 Very frequent (99-80%)
10 abnormality of the sclera 55 Very frequent (99-80%)
11 abnormal sclera morphology 31 hallmark (90%) HP:0000591

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 MMP9 CCL11 CCL5 CXCR3 ICAM1 IL13
2 digestive/alimentary MP:0005381 9.65 IL5 MMP9 ICAM1 IL13 IL4
3 immune system MP:0005387 9.56 IL5 MMP9 CCL11 CCL5 CXCR3 ICAM1
4 respiratory system MP:0005388 9.1 IL5 MMP9 CCL11 CXCR3 IL13 IL4

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
4
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
6
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
7
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
8 Tetrahydrozoline Phase 4,Phase 3,Phase 2
9 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
10 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
11 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
12
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
13 Dexamethasone acetate Phase 4 1177-87-3
14 glucocorticoids Phase 4
15
protease inhibitors Phase 4
16 Respiratory System Agents Phase 4,Phase 3,Phase 2
17 N-acetyl-1-aspartylglutamic acid Phase 4
18 Nasal Decongestants Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4
20 Neuroprotective Agents Phase 4
21 Neurotransmitter Agents Phase 4,Phase 3
22 Cyclosporins Phase 4,Phase 3,Phase 2
23 Histamine Antagonists Phase 4,Phase 3
24 Histamine H1 Antagonists Phase 4,Phase 3
25 HIV Protease Inhibitors Phase 4
26 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
27 Hormone Antagonists Phase 4
28 Dermatologic Agents Phase 4,Phase 3,Phase 2
29 Hormones Phase 4
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
31 Anti-Allergic Agents Phase 4,Phase 3
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
33 Anti-Asthmatic Agents Phase 4
34 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
35 Antiemetics Phase 4
36 Anti-Infective Agents Phase 4,Phase 3,Phase 2
37 Antifungal Agents Phase 4,Phase 3,Phase 2
38 Anti-Inflammatory Agents Phase 4
39 Protective Agents Phase 4
40 Antineoplastic Agents, Hormonal Phase 4
41 BB 1101 Phase 4
42 Autonomic Agents Phase 4,Phase 3,Phase 2
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2
44 Bronchodilator Agents Phase 4
45
Ketotifen Approved Phase 3 34580-13-7, 34580-14-8 3827
46 Antipruritics Phase 3
47 Acidophilus Nutraceutical Phase 2, Phase 3
48 Antibodies, Monoclonal Phase 1
49 Immunoglobulins Phase 1
50 Antibodies Phase 1

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
3 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
4 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
5 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
6 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
7 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
8 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
9 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
10 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
11 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Recruiting NCT03379311 Phase 1
12 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

38
Eye, Testes, Neutrophil, T Cells, Thyroid

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 332)
# Title Authors Year
1
Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia. ( 29338965 )
2018
2
Vernal keratoconjunctivitis. ( 29391772 )
2018
3
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 29040120 )
2018
4
Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis. ( 29040121 )
2018
5
Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale. ( 29367201 )
2018
6
Sequential Keraring implantation and corneal cross-linking for the treatment of keratoconus in children with vernal keratoconjunctivitis. ( 29123375 )
2017
7
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
8
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
9
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2017
10
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
11
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
12
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
13
Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. ( 29090512 )
2017
14
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
15
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
16
Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. ( 29118487 )
2017
17
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
18
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
19
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
20
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
21
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
22
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
23
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
24
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
25
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
26
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
27
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
28
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
29
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
30
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
31
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016
32
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
33
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
34
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
35
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
36
Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. ( 25712437 )
2015
37
[Vernal keratoconjunctivitis]. ( 26464371 )
2015
38
Topographic corneal changes in children with vernal keratoconjunctivitis: A report from Kathmandu, Nepal. ( 26070227 )
2015
39
Deep Anterior Lamellar Keratoplasty in Keratoconic Patients with versus without Vernal Keratoconjunctivitis. ( 26425311 )
2015
40
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. ( 26768065 )
2015
41
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis. ( 25756057 )
2015
42
In vivo confocal microscopy of meibomian glands and palpebral conjunctiva in vernal keratoconjunctivitis. ( 26044472 )
2015
43
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? ( 25692810 )
2015
44
Dry Eye in Vernal Keratoconjunctivitis: A Cross-Sectional Comparative Study. ( 26496269 )
2015
45
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics. ( 25744396 )
2015
46
Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis. ( 26235361 )
2015
47
Corneal complications of vernal keratoconjunctivitis. ( 26258926 )
2015
48
Is there is an association between the presence of Staphylococcus species and occurrence of vernal keratoconjunctivitis? ( 26586974 )
2015
49
Intracellular IL-4, IL-5, and IFN-I^ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis. ( 25999672 )
2015
50
Images in clinical medicine. Giant papillae in vernal keratoconjunctivitis. ( 24758619 )
2014

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.61 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.46 CCL11 CCL5 CXCR3 IL13 IL4 IL5
4
Show member pathways
13.34 CCL11 CCL5 ICAM1 IL13 IL4 IL5
5
Show member pathways
13.21 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.15 CCL11 CCL5 ICAM1 IL13 IL4 IL5
7
Show member pathways
13.11 CCL11 CCL5 CXCR3 IL13 IL4 IL5
8 12.67 IL13 IL4 IL5 MMP9
9
Show member pathways
12.63 CCL5 ICAM1 IL13 IL4
10
Show member pathways
12.62 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
11
Show member pathways
12.21 IL13 IL4 IL5
12
Show member pathways
12.18 CCL11 CCL5 ICAM1
13
Show member pathways
12.17 CCL5 ICAM1 IL4
14
Show member pathways
12.1 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.05 CCL11 CCL5 CXCR3 ICAM1 MMP9
16
Show member pathways
12.01 IL13 IL4 IL5
17 11.87 ICAM1 IL4 MMP9
18
Show member pathways
11.85 CCL11 CCL5 CXCR3
19 11.81 CCL5 ICAM1 MMP9
20 11.69 ICAM1 IL13 IL4 IL5
21 11.66 CXCR3 IL13 IL4 IL5
22 11.58 ICAM1 IL4 IL5
23 11.55 CCL11 IL4 IL5
24 11.41 CCL11 ICAM1 IL13 IL4 MMP9
25 11.36 ICAM1 MMP9
26 11.27 CCL5 MMP9
27 11.25 CCL5 ICAM1 IL13 IL4
28 11.22 IL13 IL4 IL5
29 11.21 CCL11 CXCR3
30 11.19 IL4 IL5
31 11.18 IL13 IL4 IL5
32 11.15 CCL5 MMP9
33 11.12 CCL11 IL13 IL4 IL5
34 11.1 IL13 IL4 IL5
35 11.05 ICAM1 MMP9
36 10.95 CCL11 CCL5 IL13 IL4 IL5
37 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
38 10.86 CCL5 MMP9
39 10.86 CCL11 CCL5 IL13 IL4 IL5
40 10.69 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 external side of plasma membrane GO:0009897 9.33 CXCR3 ICAM1 IL13
3 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 CCL11 CCL5 IL13 IL4 IL5
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 CCL11 CCL5 ICAM1
3 positive regulation of cell migration GO:0030335 9.71 CCL11 CCL5 MMP9
4 cellular response to tumor necrosis factor GO:0071356 9.69 CCL11 CCL5 ICAM1
5 cellular response to interferon-gamma GO:0071346 9.65 CCL11 CCL5 ICAM1
6 regulation of receptor activity GO:0010469 9.65 CCL11 CCL5 IL13 IL4 IL5
7 cellular response to interleukin-1 GO:0071347 9.63 CCL11 CCL5 ICAM1
8 chemokine-mediated signaling pathway GO:0070098 9.61 CCL11 CCL5 CXCR3
9 positive regulation of actin filament polymerization GO:0030838 9.58 CCL11 ICAM1
10 monocyte chemotaxis GO:0002548 9.57 CCL11 CCL5
11 leukocyte cell-cell adhesion GO:0007159 9.55 CCL5 ICAM1
12 positive regulation of JAK-STAT cascade GO:0046427 9.52 CCL5 IL5
13 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
14 eosinophil chemotaxis GO:0048245 9.49 CCL11 CCL5
15 chemotaxis GO:0006935 9.46 CCL11 CCL5 CXCR3 IL4
16 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.13 ICAM1 IL13 IL4
18 inflammatory response GO:0006954 9.02 CCL11 CCL5 CXCR3 IL13 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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