Vernal Keratoconjunctivitis malady

NIH Rare Diseases: Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.³⁰

MalaCards: Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to superior limbic keratoconjunctivitis and papillary conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is CCL24 (chemokine (C-C motif) ligand 24), and among its related pathways are Immune response Oncostatin M signaling via JAK-Stat in human cells and Class A/1 (Rhodopsin-like receptors). The drugs lodoxamide tromethamine and lodoxamide and the compounds budesonide and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are respiratory system and immune system.

Wikipedia: Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting...⁴⁴ more...

vernal keratoconjunctivitis 30 keratoconjunctivitis, vernal 43 keratoconjunctivitis vernal 32

keratoconjunctivitis 43 vkc 30

Diseases related to vernal keratoconjunctivitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 600)

id	Related Disease	Score	Top Affiliating Genes
1	superior limbic keratoconjunctivitis	31.5	MMP1, MMP3
2	papillary conjunctivitis	31.4	CCL11, CCL24, PRG2
3	giant papillary conjunctivitis	31.2	IL5, CCL11, RNASE3
4	allergic conjunctivitis	31.1	IL13, IL4, IL5, CCL11, IGHE, ICAM1
5	asthma	30.1	IL13, IL4, CCL2, CCL11, CCL5, IGES
6	allergic rhinitis	29.7	IL13, IL4, IL5, CCL11, IGHE, ICAM1
7	corneal ulcer	27.8	MMP9, CCL11, NGF, PRG2
8	conjunctivitis	27.8	VEGFA, CD36, MMP8, MMP9, FGF2, IL13
9	allergic asthma	26.2	VCAM1, CD86, IL13, IL3, IL4, IL5
10	keratoconjunctivitis	23.6	VEGFA, VCAM1, CMA1, CD36, CD86, ITGA6
11	rhinitis	21.5	VEGFA, VCAM1, CMA1, CD86, MMP9, IL13
12	dermatographia	13.7	IGHE, PRG2
13	chronic eosinophilic pneumonia	13.6	IL5, CCL11, RNASE3
14	neurogenic bladder	13.5	CMA1, IGES, IGHE
15	familial eosinophilia	13.5	IL3, IL5, PRG2
16	mast-cell leukemia	13.5	CCL2, CCL1, CCL5
17	contact dermatitis	13.4	IL5, IGHE, CXCL9, CXCR3
18	bronchitis	13.4	IL5, CCL11, IGHE, RNASE3
19	respiratory syncytial virus infectious disease	13.4	IL13, IL5, CCL5
20	osteochondritis dissecans	13.4	CD36, MMP13, MMP3
21	malignant ovarian cyst	13.4	MMP1, MMP13, MMP8
22	pthirus pubis infestation	13.4	IL5, CCL11, IGHE, NGF
23	metaphyseal anadysplasia	13.4	MMP13, MMP9
24	lymphadenitis	13.4	ICAM1, CXCL9, CXCR3
25	paragonimiasis	13.4	IL5, CCL17, IGHE, RNASE3, CXCR3
26	extrinsic allergic alveolitis	13.3	CCL2, CCL5, CXCR3
27	proctitis	13.3	FGF2, RNASE3, ABP1
28	cryptosporidiosis	13.3	IL4, CCL11, CCL5
29	congenital amegakaryocytic thrombocytopenia	13.3	IL3, THPO
30	egg allergy	13.3	IL4, IL5, IGHE
31	gastroenteritis	13.3	IL5, CCL11, IGES, IGHE, PRG2
32	allergic bronchopulmonary aspergillosis	13.3	IL4, IL5, IGES, IGHE
33	helminthiasis	13.3	IL13, IL5, IGHE, RNASE3
34	common cold	13.3	IL5, CCL11, ICAM1, RNASE3
35	eosinophilic gastroenteritis	13.3	IL5, CCL11, IGES, IGHE, RNASE3, PRG2
36	intestinal schistosomiasis	13.3	IL13, IL5
37	cyclic thrombocytopenia	13.3	IL3, THPO
38	b cell deficiency	13.3	IL4, IL5, CCL7, IGHE
39	mast cell neoplasm	13.3	CMA1, MMP3, IL3
40	cough variant asthma	13.3	IL4, IL5, IGHE, RNASE3
41	allergic contact dermatitis of eyelid	13.3	IL5, ICAM1, CXCL11, CXCL9, CXCR3
42	acute megakaryoblastic leukemia	13.3	CD36, IL3, THPO
43	myelofibrosis	13.3	FGF2, IL3, THPO
44	cutaneous t cell lymphoma	13.2	IL4, IL5, CCL17, CXCR3
45	epidermolysis bullosa dystrophica	13.2	CD36, MMP1, MMP3
46	hypersensitivity reaction type iv disease	13.2	IL4, IGHE, ICAM1
47	cutaneous leishmaniasis	13.2	IL13, IL4, IL5
48	omenn syndrome	13.2	IL4, IL5, IGHE
49	lacrimal duct obstruction	13.2	MMP3, CCL11, IGES, NGF, RNASE3, HBEGF
50	toxic epidermal necrolysis	13.1	MMP9, CCL22, CCL17, CCL5, CXCR3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 lodoxamide, lodoxamide tromethamine

MalaCards organs/tissues related to vernal keratoconjunctivitis:

²²

MGI Mouse Phenotypes related to vernal keratoconjunctivitis:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	PRG2, CCL24
2	immune system phenotype	MP:0005387	8.8	ITGA6, CD86, MMP10, MMP3, MMP8, SMAD2
3	hematopoietic system phenotype	MP:0005397	8.8	IL5, CCL7, CCL24, CCL11, IL3, FGF2
4	integument phenotype	MP:0010771	8.0	IL13, HBEGF, EGFR, NGF, SMAD2, IL4
5	growth/size phenotype	MP:0005378	7.7	HBEGF, EGFR, NGF, VCAM1, SMAD2, IL13
6	digestive/alimentary phenotype	MP:0005381	7.4	MMP9, ITGA6, VEGFA, CCL2, SMAD2, CD36
7	reproductive system phenotype	MP:0005389	7.2	MMP9, TGFB1, TIMP1, CRISP3, IL13, SMAD2
8	tumorigenesis	MP:0002006	6.6	ITGA6, MMP9, CXCR3, MMP8, FGF2, IL3
9	vision/eye phenotype	MP:0005391	6.2	VEGFA, CD36, ITGA6, MMP9, TGFB1, EGFR
10	cardiovascular system phenotype	MP:0005385	5.7	ICAM1, TMSB4X, VCAM1, MMP13, CCL2, CD36
11	homeostasis/metabolism phenotype	MP:0005376	5.0	SMAD2, ICAM1, IGHE, CCL2, EGFR, HBEGF
12	cellular phenotype	MP:0005384	4.6	TGFB1, IL13, VCAM1, VEGFA, CD36, CD86

Articles related to vernal keratoconjunctivitis:

(show all 38)

id	Title	Authors	Year	Affiliating Genes
1	Transforming growth factor-I^/Smad - signalling pathwa y and conjunctival remodelling in vernal keratoconjunctivitis. (20977504)	Leonardi A.... Brun P.	2011	TGFB1, SMAD2
2	Vernal keratoconjunctivitis--a rare but serious comor bidity of allergic rhinitis and eustachian tube dysfunction. (19900723)	Bozkurt M.K.... Reisli I.	2010	IGHE
3	Treatment of severe vernal keratoconjunctivitis with 1% topical cyclosporine in an Italian cohort of 197 children. (19840298)	Tesse R.... Armenio L.	2010	IGES
4	Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis. (19333691)	Shoji J.... Sawa M.	2009	CCL11, CCL24
5	Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. (19220217)	Leonardi A.... Sack R.	2009	MMP3, MMP8, MMP13
6	Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva. (17653039)	Micera A.... Bonini S.	2007	NGF
7	Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma. (17517101)	Leonardi A.... Abatangelo G.	2007	PITRM1
8	Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis. (15746957)	Abu El-Asrar A.M.... Geboes K.	2006	EGFR, FGF2, VEGFA
9	Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis. (16427347)	Kumagai N.... Nishida T.	2006	ICAM1, VCAM1, CCL11
10	Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)	Shoji J.... Sawa M.	2006	CCL24
11	Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis. (17200658)	Micera A.... Rasi G.	2006	TMSB4X
12	Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis. (15629970)	Pucci N.... Vierucci A.	2005	IGES
13	Tear chymase in vernal keratoconjunctivitis. (15512949)	Ebihara N.... Murakami A.	2004	CMA1
14	Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. (14501439)	Bonini S.... Bonini S.	2003	IL3, IL4, CCL5
15	Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis. (12824251)	Leonardi A.... Secchi A.G.	2003	MMP9, RNASE3
16	The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)	Abu El-Asrar A.M.... Geboes K.	2003	CXCL11, CXCL9
17	Neutrophil and eosinophil participation in atopic and vernal keratoconjunctivitis. (12868012)	Trocme S.D.... Dohlman C.H.	2003	PRG2, CRISP3
18	Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. (12234902)	El-Asrar A.M.... Geboes K.	2002	CCL22, CCL1
19	High level of Fc epsilon receptor I-bindable immunoglobulin E in the tear fluid and increased immunoglobulin E-saturated cells in the giant papillae of vernal keratoconjunctivitis patients. (12225812)	Ebihara N.... Ra C.	2002	IGHE
20	Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80). (11702979)	Abu-El-Asrar A.M.... Geboes K.	2001	CD86
21	Expression of chemokine receptors in vernal keratoconjunctivitis. (11673306)	Abu El-Asrar A.M.... Geboes K.	2001	CXCR3
22	Expression of CD23/CD21 and CD40/CD40 ligand in vernal keratoconjunctivitis. (11339595)	Abu El-Asrar A.M.... Geboes K.	2001	IGHE
23	Gelatinase B in vernal keratoconjunctivitis. (11594952)	Abu El-Asrar A.M.... Geboes K.	2001	MMP9
24	Chemokines in the limbal form of vernal keratoconjunctivitis. (11090473)	Abu El-Asrar A.M.... Geboes K.	2000	CCL2, CCL11, CCL5
25	Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. (10606937)	Uchio E.... Ohno S.	2000	IL4, IL5
26	Increased plasma levels of substance P in vernal keratoconjunctivitis. (9331280)	Lambiase A.... Aloe L.	1997	NGF
27	Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis. (9135403)	Leonardi A.... Secchi A.G.	1997	RNASE3
28	Adhesion molecules in vernal keratoconjunctivitis. (9497473)	Abu El-Asrar A.M.... Desmet V.	1997	ICAM3
29	ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: case report. (8985642)	Gill K.S.... TrocmAc S.D.	1997	ICAM1
30	Immunopathogenesis of vernal keratoconjunctivitis. (9009358)	Abu El-Asrar A.M.... Missotten L.	1996	ICAM3
31	Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (7657550)	Lambiase A.... Aloe L.	1995	NGF, IGHE
32	Collagen types I and III in giant papillae of vernal keratoconjunctivitis. (7612563)	Leonardi A.... Secchi A.G.	1995	CD36
33	Eosinophil cationic protein in tears of normal subjec ts and patients affected by vernal keratoconjunctivitis. (8588697)	Leonardi A.... Plebani M.	1995	RNASE3
34	Histaminase activity in patients with vernal keratoconjunctivitis. (9098303)	Abelson M.B.... Secchi A.G.	1995	ABP1
35	Vernal keratoconjunctivitis: a model of 5q cytokine gene cluster disease. (7613225)	Bonini S.... Rutella S.	1995	IGHE
36	Measurement of IL-4 in tears of patients with seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (7586697)	Fujishima H.... Tsubota K.	1995	IL4
37	IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)	Montan P.G.... Scheynius A.	1995	IGHE
38	Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)	Tomassini M.... Bonini S.	1994	RNASE3

Genes related to vernal keratoconjunctivitis according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
2	ICAM3	intercellular adhesion molecule 3	11.0	Publications
3	IGES	immunoglobulin E concentration, serum	11.0	Publications
4	CCL8	chemokine (C-C motif) ligand 8	11.0	Publications
5	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
6	CCL1	chemokine (C-C motif) ligand 1	11.0	Publications
7	CRISP3	cysteine-rich secretory protein 3	11.0	Publications
8	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
9	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
10	CXCL11	chemokine (C-X-C motif) ligand 11	11.0	Publications
11	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
12	PITRM1	pitrilysin metallopeptidase 1	11.0	Publications
13	CMA1	chymase 1, mast cell	11.0	Publications
14	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
15	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications
16	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
17	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
18	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
19	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
20	CD86	CD86 molecule	11.0	Publications
21	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
22	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
23	THPO	thrombopoietin	11.0	Publications
24	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
25	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
26	ITGA6	integrin, alpha 6	11.0	Publications
27	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
28	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
29	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
30	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
31	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
32	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
33	SMAD2	SMAD family member 2	11.0	Publications
34	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
35	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
36	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
37	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
38	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
39	ICAM1	intercellular adhesion molecule 1	11.0	Publications
40	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
41	IL13	interleukin 13	11.0	Publications
42	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
43	IL4	interleukin 4	11.0	Publications
44	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
45	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
46	TGFB1	transforming growth factor, beta 1	11.0	Publications
47	EGFR	epidermal growth factor receptor	11.0	Publications
48	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to vernal keratoconjunctivitis according to GeneDecks:

(show top 50)    (show all 101)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.0	CCL2, CCL11, TIMP1
2	Class A/1 (Rhodopsin-like receptors)38	9.7	CXCR3, CCL22, CXCL9, CXCL11, CCL5, CCL11
3	Glioma Invasiveness36	9.4	THPO, ITGA6, FGF2, IL3, TIMP1
4	RAR-Gamma-RXR-Alpha Degradation36	9.4	CXCL9, CXCL11, CCL11, CCL22, CCL7, CCL8
5	Metalloproteases in connective tissue degradation10	9.3	MMP8, CMA1, MMP9, MMP3, MMP13, MMP10
6	Cell adhesion Cell-matrix glycoconjugates10	9.3	CCL5, TIMP2, CCL8, MMP3, MMP1, MMP9
7	Cell adhesion_Cell-matrix glycoconjugates41	9.3	TIMP2, MMP3, MMP9, CCL8, CCL5, MMP1
8	Chemokine Signaling36	9.2	CCL24, CCL5, CXCL11, CXCL9, CCL1, CCL2
9	Chemokine signaling pathway20	9.2	CCL11, CCL7, CXCR3, CXCL9, CXCL11, CCL5
10	JNK Pathway36	9.1	FGF2, IL3, CCL8, CCL7, CCL11, THPO
11	Asthma20	9.1	IL13, IL3, IL4, IL5, PRG2, CCL11
12	Inhibition of Matrix Metalloproteinases36	9.0	TIMP2, TIMP1, MMP8, MMP9, MMP3, MMP13
13	Activation of Matrix Metalloproteinases38	9.0	CMA1, MMP1, MMP10, MMP13, MMP3, MMP8
14	UPA-UPAR Pathway36	9.0	ITGA6, PRG2, MMP9, MMP3, MMP13, MMP10
15	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	8.9	VEGFA, MMP1, CCL2, TIMP1, CCL11
16	PTEN Pathway36	8.9	EGFR, THPO, FGF2, PRG2, ITGA6
17	Angiogenesis3	8.8	MMP9, TIMP1, ITGA6, FGF2, TGFB1, TIMP2
18	PGC1Alpha Pathway36	8.7	IL13, IL3, IL4, IL5, CCL8, CCL7
19	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	IL13, IL4, IL5, TGFB1
20	NFAT Signaling and Lymphocyte Interactions36	8.5	CCL7, CCL22, CCL2, CCL11, CCL17, CCL1
21	Regulation of eIF4 and p70S6K36	8.5	ITGA6, IL13, IL3, IL4, IL5, CCL8
22	Akt Signaling36	8.5	CXCL11, CXCL9, CXCR3, THPO, CCL5, CCL24
23	PPAR Pathway36	8.5	TIMP2, EGFR, IL3, ITGA6, FGF2, THPO
24	IL-6 Pathway36	8.4	IL3, IL4, IL5, CCL8, CCL7, CCL2
25	Cell adhesion ECM remodeling10	8.2	MMP1, MMP10, TIMP2, TIMP1, HBEGF, EGFR
26	Cell adhesion_ECM remodeling41	8.2	MMP9, HBEGF, TIMP1, TIMP2, MMP3, MMP1
27	MIF Regulation of Innate Immune Cells36	8.1	IL4, IL5, CCL8, CCL7, CCL22, CCL2
28	MIF Mediated Glucocorticoid Regulation36	8.1	CXCL9, IL13, IL3, IL4, IL5, CCL8
29	all-trans-Retinoic Acid Signaling in Brain36	8.1	IL13, IL3, IL4, IL5, CCL8, CCL7
30	SOCS Pathway36	8.1	CCL17, CCL1, CCL24, CCL5, CCL11, CCL2
31	PEDF Induced Signaling36	8.1	CXCL9, CXCL11, CCL5, IL3, IL13, CCL24
32	STAT3 Pathway36	8.0	IL13, IL3, IL4, IL5, CCL8, CCL7
33	Rheumatoid arthritis20	8.0	CD86, VEGFA, ICAM1, MMP1, CCL2, MMP3
34	Endothelin-1 Signaling Pathway36	7.9	EGFR, CXCL11, CXCL9, CCL1, CCL5, IL13
35	Glucocorticoid Receptor Signaling36	7.7	CCL17, CCL1, CCL24, CCL5, TGFB1, CCL11
36	Rac1 Pathway36	7.6	EGFR, ITGA6, TGFB1, FGF2, IL3, THPO
37	Renin-Angiotensin Pathway36	7.3	FGF2, EGFR, CCL2, VCAM1, TGFB1, THPO
38	Transendothelial Migration of Leukocytes36	7.2	MMP1, MMP10, MMP13, MMP3, MMP8, MMP9
39	Pancreatic Adenocarcinoma36	6.8	THPO, TGFB1, MMP10, MMP13, IL3, MMP9
40	ERK Signaling36	6.4	TGFB1, PRG2, CXCL11, CXCL9, THPO, TIMP2
41	Molecular Mechanisms of Cancer36	6.4	ITGA6, TIMP2, CCL1, CCL17, IL5, CCL8
42	JAK-STAT Pathway36	6.0	TGFB1, CCL8, CCL7, CCL22, CCL2, CCL11
43	MAPK Family Pathway36	6.0	TIMP1, TIMP2, THPO, TGFB1, EGFR, CCL5
44	TGF-Beta Pathway36	6.0	FGF2, IL13, IL3, IL4, IL5, CCL8
45	Cytokine-cytokine receptor interaction20	6.0	CCL2, CCL11, CCL17, CCL1, CCL24, CCL5
46	PAK Pathway36	5.7	FGF2, IL13, IL3, TIMP2, IL4, IL5
47	Tec Kinases Signaling36	5.7	CCL1, CCL24, CCL5, EGFR, TIMP1, TIMP2
48	Antioxidant Action of Vitamin-C36	5.6	TIMP1, TIMP2, THPO, TGFB1, CXCL11, CXCL9
49	p38 Signaling36	5.6	CCL8, CXCR3, CXCL9, CXCL11, CCL7, CCL22
50	Rho Family GTPases36	5.5	EGFR, TIMP1, TIMP2, THPO, TGFB1, PRG2

Compounds related to vernal keratoconjunctivitis according to GeneDecks:

(show top 50)    (show all 291)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.1	RNASE3, IGHE, CCL11, CD36
2	glycosaminoglycan32	9.4	HBEGF, FGF2, MMP8, MMP13, CD36
3	groalpha32	8.8	CXCR3, CXCL9, ICAM1, CCL5, CCL11, CCL2
4	(4-aminophenyl)mercuric acetate32	8.8	TIMP2, TIMP1, MMP9, MMP8, MMP3, MMP13
5	allergens32	8.8	CCL17, CCL11, IL5, IL4, IL13, CD86
6	hyaluronic acid32 18	9.6	CD36, THPO, TIMP2, RNASE3, IL13, FGF2
7	cysteine32	8.6	CMA1, MMP1, MMP13, TIMP2, TIMP1, SMAD2
8	fluticasone propionate32 42 9 9	11.5	RNASE3, IGHE, CCL5, CCL11, IL5, IL4
9	ccl432	8.4	CCL8, IL13, MMP13, CCL7, CCL22, CCL2
10	ccl332	8.4	CCL5, CCL24, CCL1, CCL17, CCL11, CCL2
11	leukotriene b432 42 18	10.3	CCL8, CCL7, CCL22, CCL2, CCL11, CCL5
12	heparin32 9 18 9	11.2	CXCR3, PRG2, CD36, THPO, CMA1, MMP13
13	il 1032	8.1	CXCR3, CXCL9, TGFB1, CCL5, CCL17, CCL2
14	methacholine32 9 9	10.0	IL13, IL4, IL5, CCL22, PRG2, TGFB1
15	marimastat32 42 9 9	11.0	MMP10, MMP1, VEGFA, MMP13, MMP3, MMP8
16	doxycycline32 9 9	9.9	MMP3, MMP8, IL13, MMP13, FGF2, IL3
17	fmlp32	7.9	CXCR3, PRG2, IL13, VCAM1, IL3, IL5
18	fibrinogen32	7.9	MMP13, MMP8, CCL22, CCL2, TMSB4X, TIMP2
19	tarc32	7.9	CCL17, CCL11, CCL2, CCL22, CCL7, CCL8
20	batimastat32 42 9 9	10.8	MMP9, MMP8, MMP3, MMP13, MMP10, MMP1
21	pge232	7.5	CCL22, IL5, IL13, FGF2, MMP8, MMP3
22	gm-csf32	7.4	ICAM1, CCL5, CCL2, IL5, IL4, IL3
23	tacrolimus32 34 9 9	10.4	CCL22, IL5, IL4, IL3, IL13, CD86
24	tgf beta132	7.4	SMAD2, CCL2, IL13, FGF2, MKI67, MMP3
25	estrogen32	7.4	PRG2, TIMP2, TIMP1, HBEGF, EGFR, RNASE3
26	cytochalasin d32 42	8.3	TGFB1, VCAM1, CD36, TIMP2, TIMP1, ICAM1
27	indomethacin32 9 9	9.2	IL13, MMP3, MMP13, MMP1, IL4, PRG2
28	ly29400232	6.7	CCL2, IL4, IL13, FGF2, MMP9, VEGFA
29	sb 20358032 42	7.6	THPO, TIMP2, TIMP1, HBEGF, NGF, SMAD2
30	nitric oxide32 9 18 9	9.5	SMAD2, ICAM1, IGES, CCL5, CCL1, CCL17
31	thymidine32 18	7.3	CXCR3, TGFB1, MMP13, TIMP2, HBEGF, SMAD2
32	histamine32 18	7.2	CCL2, CCL22, CCL7, IL5, IL4, IL3
33	curcumin32	6.2	CCL2, EGFR, TIMP1, TGFB1, CCL7, MMP9
34	lactate32	6.2	CCL5, IL3, IL13, MKI67, MMP9, MMP8
35	calcium32 9 18 9	8.8	CMA1, CXCR3, CXCL9, CXCL11, PRG2, THPO
36	herbimycin a32 42	6.8	IL4, IL3, FGF2, MMP9, MMP13, MMP1
37	actinomycin d32	5.8	NGF, ICAM1, IGHE, CCL24, CCL11, CCL2
38	n acetylcysteine32	5.7	MMP9, MMP3, MMP1, VCAM1, VEGFA, IL3
39	vegf32	5.3	MMP3, MMP13, MMP10, MMP1, ITGA6, CD36
40	matrigel32	5.3	SMAD2, TMSB4X, ICAM1, CCL5, CCL11, FGF2
41	cyclosporin a32 42	6.2	TGFB1, TIMP2, TIMP1, RNASE3, NGF, ICAM1
42	rantes32	5.1	CCL5, CCL24, CCL1, CCL17, CCL11, CCL2
43	genistein32 9 18 9	7.8	IL3, FGF2, MMP9, MMP3, MMP13, MMP1
44	paraffin32	4.7	VCAM1, VEGFA, CMA1, CD36, TGFB1, TIMP2
45	pd 98,05932	4.7	TIMP1, HBEGF, EGFR, NGF, SMAD2, ICAM1
46	serine32	3.9	CXCR3, TGFB1, TIMP2, MKI67, MMP9, MMP8
47	retinoic acid32 42 18	5.8	CCL5, VCAM1, CD36, ITGA6, MMP1, CCL11
48	tyrosine32	3.7	CXCR3, CXCL9, PRG2, CCL7, CCL8, IL5
49	dexamethasone32 42 34 9 9	7.4	TIMP1, HBEGF, RNASE3, NGF, SMAD2, ICAM3
50	cycloheximide32	3.3	IL4, IL3, IL13, FGF2, MKI67, MMP9

Cellular components related to vernal keratoconjunctivitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.0	VEGFA, TMSB4X, TIMP1, TGFB1
2	external side of plasma membrane	GO:009897	8.2	CXCR3, CXCL9, IL4, IL13, ITGA6, CD86
3	proteinaceous extracellular matrix	GO:005578	7.6	MMP10, MMP13, CRISP3, MMP3, MMP8, MMP9
4	extracellular region	GO:005576	4.3	TIMP2, CCL5, CCL17, CCL11, CCL2, CCL22
5	extracellular space	GO:005615	3.5	CXCL9, CCL7, IL5, IL4, IL3, IL13

Biological processes related to vernal keratoconjunctivitis according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	eosinophil chemotaxis	GO:048245	10.4	CCL7, CCL11, CCL24, CCL5
2	chronic inflammatory response	GO:002544	10.2	CCL11, CCL5, VCAM1
3	monocyte chemotaxis	GO:002548	10.2	CCL7, CCL5, CCL2
4	chemokine-mediated signaling pathway	GO:070098	9.8	CCL5, CCL2, CXCR3
5	response to nicotine	GO:035094	9.8	NGF, MMP9, IL13
6	cellular response to interleukin-1	GO:071347	9.8	ICAM1, MMP9, CCL2, CCL5
7	response to cholesterol	GO:070723	9.8	SMAD2, CCL5, TGFB1
8	positive chemotaxis	GO:050918	9.7	VEGFA, CCL5, FGF2
9	leukocyte cell-cell adhesion	GO:007159	9.7	ICAM1, CCL5, VCAM1
10	response to radiation	GO:009314	9.6	CCL11, TGFB1, NGF, MMP9
11	collagen catabolic process	GO:030574	9.5	MMP10, MMP9, MMP8, MMP3, MMP13, MMP1
12	cellular response to organic cyclic compound	GO:071407	9.5	CCL5, TGFB1, CCL2, ITGA6
13	positive regulation of endothelial cell proliferation	GO:001938	9.5	VEGFA, CCL24, CCL2, FGF2, CCL11
14	positive regulation of phosphorylation	GO:042327	9.4	ITGA6, CCL5, EGFR
15	positive regulation of angiogenesis	GO:045766	9.4	CCL5, VEGFA, MMP9, FGF2, CCL11, CCL24
16	regulation of cell shape	GO:008360	9.4	ICAM1, CCL24, CCL11, CCL2, CCL7, VEGFA
17	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	CCL5, TGFB1, CCL2
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	IL3, VEGFA, CD36, IL5
19	cellular calcium ion homeostasis	GO:006874	9.3	CCL5, CCL1, CCL11, CCL7, CCL8, TGFB1
20	positive regulation of blood vessel endothelial cell migration	GO:043536	9.3	FGF2, VEGFA, TGFB1
21	aging	GO:007568	9.2	VCAM1, TIMP1, CCL5, TGFB1, CCL2
22	response to ethanol	GO:045471	9.2	IL4, ICAM1, CCL2, MMP9, IL13
23	proteolysis	GO:006508	9.2	MMP8, PITRM1, MMP9, MMP13, CMA1, MMP1
24	cell-cell signaling	GO:007267	9.1	CXCL11, CCL5, CCL24, CCL17, CCL22, CCL7
25	platelet degranulation	GO:002576	9.1	TGFB1, CD36, TMSB4X, TIMP1, VEGFA
26	protein kinase B signaling cascade	GO:043491	9.1	CCL2, CCL5, TGFB1
27	extracellular matrix disassembly	GO:022617	9.0	CMA1, MMP10, MMP1, TIMP1, MMP13, TIMP2
28	extracellular matrix organization	GO:030198	9.0	CMA1, MMP8, MMP9, TIMP1, TIMP2, MMP3
29	platelet activation	GO:030168	8.8	TMSB4X, TIMP1, TGFB1, VEGFA, THPO, CD36
30	MAPK cascade	GO:000165	8.7	CCL2, CCL5, EGFR, TGFB1
31	chemotaxis	GO:006935	8.6	CCL1, CXCL11, CXCL9, CCL17, CCL11, CCL2
32	response to hypoxia	GO:001666	8.6	TGFB1, CCL2, MMP9, VCAM1, VEGFA
33	response to drug	GO:042493	8.4	NGF, ICAM1, CCL5, IL4, MMP9, TGFB1
34	positive regulation of cell migration	GO:030335	8.2	EGFR, HBEGF, TGFB1, CCL5, CCL24, CCL11
35	immune response	GO:006955	8.2	IL3, IL5, CCL7, CCL22, CCL11, CCL17
36	blood coagulation	GO:007596	8.2	TIMP1, THPO, ITGA6, TMSB4X, VEGFA, TGFB1
37	inflammatory response	GO:006954	8.2	CCL5, CCL17, NGF, CCL24, CCL2, TGFB1
38	signal transduction	GO:007165	8.1	CCL7, CCL22, CXCL11, HBEGF, EGFR, CCL24
39	positive regulation of cell proliferation	GO:008284	7.5	CD86, VEGFA, FGF2, IL3, NGF, EGFR

Molecular functions related to vernal keratoconjunctivitis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR2 chemokine receptor binding	GO:031727	10.1	CCL2, CCL7
2	integrin binding	GO:005178	9.4	TIMP2, VCAM1, ITGA6, ICAM1, ICAM3
3	chemoattractant activity	GO:042056	9.2	FGF2, VEGFA, CCL5
4	chemokine activity	GO:008009	9.2	CCL8, CCL7, CCL22, CCL2, CCL11, CCL17
5	metalloendopeptidase activity	GO:004222	9.0	MMP9, PITRM1, MMP3, MMP10, MMP13, MMP1
6	heparin binding	GO:008201	8.8	VEGFA, ABP1, CCL5, CCL2, CCL7, CCL8
7	cytokine activity	GO:005125	8.1	IL3, IL13, IL4, THPO, CXCL9, VEGFA
8	growth factor activity	GO:008083	7.7	HBEGF, TGFB1, THPO, NGF, IL5, IL4