MCID: VRN004
MIFTS: 47

Vernal Keratoconjunctivitis malady

Rare diseases, Eye diseases categories

Summaries for Vernal Keratoconjunctivitis

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NIH Rare Diseases:43 Vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards based summary: Vernal Keratoconjunctivitis, also known as spring catarrh, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is CMA1 (chymase 1, mast cell), and among its related pathways are CXCR3-mediated signaling events and Immune response Bacterial infections in normal airways. The compounds unicap and anti-histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related mouse phenotype immune system.

Wikipedia:65 Vernal keratoconjunctivitis (VKC) or Spring catarrh is a recurrent, bilateral, and self-limiting... more...

Aliases & Classifications for Vernal Keratoconjunctivitis

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Sources:
43NIH Rare Diseases, 49Orphanet, 45Novoseek, 62UMLS, 28ICD10 via Orphanet, 63UMLS via Orphanet
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Vernal Keratoconjunctivitis, Aliases & Descriptions:

Name: Vernal Keratoconjunctivitis 43 49
Spring Catarrh 43 49
Keratoconjunctivitis, Vernal 62
 
Keratoconjunctivitis Vernal 45
Vkc 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 49 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

49
vernal keratoconjunctivitis:
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet49 70476
ICD10 via Orphanet28 H16.2
UMLS via Orphanet63 C0022577

Related Diseases for Vernal Keratoconjunctivitis

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Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.2RNASE3, CCL11
2conjunctivitis31.2RNASE3
3allergic conjunctivitis31.0CCL11, RNASE3
4atopy30.6RNASE3, CMA1, CCL17, CCL22, CCL11
5giant papillary conjunctivitis30.6RNASE3, CCL11
6eosinophilia30.5RNASE3, CCL17, CCL7, CCL11
7asthma30.4RNASE3, CMA1, CCL17, CCL7, CCL22, CCL11
8allergic rhinitis30.4CCL11, RNASE3
9dermatitis30.3RNASE3, CMA1, CCL17
10uveitis30.3CCL11, CXCL11
11rhinitis30.3RNASE3, CMA1, CCL7, CCL11
12atopic dermatitis30.3CCL11, CCL22, CCL17, RNASE3
13allergic asthma30.3RNASE3, CMA1, CCL17, CCL7, CCL11
14keratoconus10.7
15keratitis10.6
16blindness10.6
17trachoma10.4
18conjunctival pigmentation10.4
19eye disease10.4
20papillary conjunctivitis10.4
21atopic keratoconjunctivitis10.4
22vernal conjunctivitis10.3
23porphyria10.3
24congenital porphyria10.3
25limbal stem cell deficiency10.2
26corneal ectasia10.2
27ocular hypertension10.2
28mooren's ulcer10.2
29amblyopia10.2
30conjunctival deposit10.2
31corneal deposit10.2
32corneal ulcer10.2
33retinitis10.2
34steroid-induced glaucoma10.2
35thyroiditis10.2
36anterior uveitis10.2
37paragonimiasis10.0CCL17
38urticaria10.0RNASE3
39chronic eosinophilic pneumonia10.0CCL11, RNASE3
40common cold10.0CCL11, RNASE3
41pulmonary eosinophilia10.0CCL11, RNASE3
42food allergy10.0CCL11, RNASE3
43hypereosinophilic syndrome10.0CCL11, RNASE3
44otitis media10.0CCL11, RNASE3
45sinusitis10.0CCL11, RNASE3
46bronchitis10.0CCL11, RNASE3
47pemphigus vulgaris10.0CCL17, CCL11
48bronchiolitis10.0CCL11, RNASE3
49interstitial lung disease10.0CCL11, CCL17
50pulmonary disease, chronic obstructive10.0CCL11, RNASE3

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to vernal keratoconjunctivitis

Symptoms for Vernal Keratoconjunctivitis

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Drugs & Therapeutics for Vernal Keratoconjunctivitis

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Drug clinical trials:

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Genetic Tests for Vernal Keratoconjunctivitis

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Anatomical Context for Vernal Keratoconjunctivitis

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MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

33
Eye, Testes, Thyroid, Neutrophil

Animal Models for Vernal Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CCL11, CCL7, CCL17, MMP10, CMA1

Publications for Vernal Keratoconjunctivitis

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Articles related to Vernal Keratoconjunctivitis:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? (25692810)
2015
2
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. (25140177)
2014
3
CCL20/MIP-3 alpha mRNA expression in the conjunctival epithelium of normal individuals and patients with vernal keratoconjunctivitis. (25172034)
2014
4
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. (25410033)
2014
5
Surgical resection and amniotic membrane transplantation for treatment of refractory giant papillae in vernal keratoconjunctivitis. (23086371)
2013
6
Management of vernal keratoconjunctivitis. (25135808)
2013
7
Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. (23625179)
2013
8
Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab. (23607979)
2013
9
Vernal keratoconjunctivitis: an update. (23038763)
2013
10
Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis. (22927736)
2012
11
Fluid-filled scleral contact lenses in vernal keratoconjunctivitis. (22367220)
2012
12
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
13
In vivo laser scanning confocal microscopy of vernal keratoconjunctivitis. (20662846)
2011
14
Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey. (21976577)
2011
15
Treatment of severe vernal keratoconjunctivitis with 1% topical cyclosporine in an Italian cohort of 197 children. (19840298)
2010
16
Vernal keratoconjunctivitis: a major review. (18786127)
2009
17
Perilimbal conjunctival pigmentation in Chinese patients with vernal keratoconjunctivitis. (17464306)
2008
18
Vernal keratoconjunctivitis at Guinness Eye Centre, Luth (a five year study). (19062462)
2008
19
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
20
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
21
Vernal keratoconjunctivitis presenting unilaterally. (16761642)
2006
22
Topical cyclosporine 0.5 per cent and preservative-free ketorolac tromethamine 0.5 per cent in vernal keratoconjunctivitis. (15061303)
2004
23
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
24
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
25
Vernal keratoconjunctivitis in Nigerians: 109 consecutive cases. (14620434)
2003
26
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
27
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
28
Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. (12234902)
2002
29
Surgical treatment of limbal vernal keratoconjunctivitis by resection of a limbal lesion. (12543198)
2002
30
Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80). (11702979)
2001
31
Expression of chemokine receptors in vernal keratoconjunctivitis. (11673306)
2001
32
Cyclosporine effects on clinical findings and impression cytology specimens in severe vernal keratoconjunctivitis. (11399937)
2001
33
Combined medical and surgical treatment of severe vernal keratoconjunctivitis. (11033129)
2000
34
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
35
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
36
Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: a flow-cytometric study. (9483586)
1998
37
Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. (9683957)
1998
38
Topical cyclosporin A 2% in the treatment of vernal keratoconjunctivitis. (9246280)
1997
39
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
40
IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)
1995
41
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (7657550)
1995
42
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
43
Lodoxamide for vernal keratoconjunctivitis. (8121328)
1994
44
Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. (8154531)
1994
45
Treatment of vernal keratoconjunctivitis a double-masked study. (22822779)
1993
46
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
47
Frequency of chlamydia in patients with vernal keratoconjunctivitis. (2488657)
1989
48
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
49
A comparison between 2% and 4% sodium cromoglycate eye drops in the treatment of vernal keratoconjunctivitis. (6821197)
1982-1983
50
Vernal keratoconjunctivitis in an Israeli group of patients and its treatment with sodium cromoglycate. (6800400)
1982

Variations for Vernal Keratoconjunctivitis

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Expression for genes affiliated with Vernal Keratoconjunctivitis

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Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for genes affiliated with Vernal Keratoconjunctivitis

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Pathways related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL11, CXCL11
2
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.6CCL11, CXCL11
39.5CCL11, CCL17
4
Show member pathways
9.3CMA1, MMP10
5
Show member pathways
9.3MMP10, CMA1
6
Show member pathways
8.4CCL11, CCL22, CCL7, CCL17
7
Show member pathways
8.0CCL11, CCL22, CCL7, CCL17, CXCL11
8
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
9
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
10
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
11
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
12
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
13
Show member pathways
8.0CXCL11, CCL17, CCL7, CCL22, CCL11
14
Show member pathways
7.6CMA1, CXCL11, CCL17, CCL7, CCL22, CCL11
15
Show member pathways
7.2MMP10, CXCL11, CCL17, CCL7, CCL22, CCL11

Compounds for genes affiliated with Vernal Keratoconjunctivitis

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Compounds related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1unicap459.9RNASE3, CCL11
2anti-histamine459.9CCL11, RNASE3
3lte4459.9CCL11, RNASE3
4sodium cromoglycate459.9CCL11, RNASE3
5cetirizine45 30 26 1312.9RNASE3, CCL11
6pranlukast45 30 1311.9CCL11, RNASE3
7ketotifen45 1310.9CCL11, RNASE3
8salmeterol45 51 30 1312.9CCL11, RNASE3
9roxithromycin45 30 1311.9CCL17, CCL11
10montelukast45 51 30 1312.8CCL11, RNASE3
11ltc4459.8RNASE3, CCL11
12budesonide45 51 1311.8RNASE3, CCL11
13fluticasone propionate45 51 61 1312.8CCL11, RNASE3
14salbutamol45 51 30 26 1313.7CCL11, RNASE3
15capsaicin45 3010.7RNASE3, CMA1
16pgd2459.7CCL11, RNASE3
17anaphylatoxin459.7CCL7, RNASE3
18n-formylmethionyl-leucylphenylalanine459.6CCL11, RNASE3
19groalpha459.6CCL11, CCL7
20pertussis459.6CCL22, CCL11
21prednisolone45 30 1311.5CCL11, RNASE3
22methacholine45 51 1311.4CCL11, CCL22, RNASE3
23fibrinogen459.4CCL22, CCL17, RNASE3
24aspirin45 51 30 2612.3RNASE3, CCL22, CCL11
25tacrolimus45 51 1311.3CCL17, CCL22, CCL11
26fmlp459.3CCL11, CCL7, RNASE3
27larc459.3CCL22, CCL7, CCL17
28dithiothreitol459.2CCL11, RNASE3
29allergens459.2CCL11, CCL17, CMA1, RNASE3
30pge2459.1CCL11, CCL22, RNASE3
31heparin45 30 26 1312.1CCL11, CMA1, RNASE3
32leukotriene b445 61 2610.8CCL11, CCL22, CCL7, RNASE3
33adp45 30 2610.8CCL22, CCL7, CCL17, RNASE3
34cyclosporin a45 30 6110.6RNASE3, CXCL11, CCL17, CCL22, CCL11
35histamine45 30 2610.5RNASE3, CMA1, CCL7, CCL22, CCL11
36tarc458.4CCL11, CCL22, CCL7, CCL17, CXCL11
37ccl345 309.4CXCL11, CCL17, CCL7, CCL22, CCL11
38ccl445 309.4CXCL11, CCL17, CCL7, CCL22, CCL11
39oligonucleotide458.1RNASE3, MMP10, CXCL11, CCL7, CCL22
40rantes458.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
41dexamethasone45 51 30 1311.0RNASE3, CXCL11, CCL17, CCL7, CCL22, CCL11
42calcium45 51 26 139.8RNASE3, CMA1, MMP10, CXCL11, CCL17, CCL7

GO Terms for genes affiliated with Vernal Keratoconjunctivitis

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Cellular components related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.2CCL11, CCL22, CCL7, CCL17, CXCL11, MMP10
2extracellular regionGO:00055766.1CCL11, RNASE3, CMA1, MMP10, CXCL11, CCL17

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:00457669.7CMA1, CCL11
2cell chemotaxisGO:00603269.6CCL17, CCL22
3eosinophil chemotaxisGO:00482459.5CCL7, CCL11
4cellular calcium ion homeostasisGO:00068749.4CCL11, CCL7
5response to virusGO:00096159.4CCL11, CCL22
6cytoskeleton organizationGO:00070109.3CCL11, CCL7
7regulation of cell shapeGO:00083609.2CCL11, CCL7
8extracellular matrix disassemblyGO:00226179.0MMP10, CMA1
9cell-cell signalingGO:00072678.7CCL22, CCL7, CCL17, CXCL11
10signal transductionGO:00071658.6CCL11, CCL22, CCL7, CXCL11
11chemotaxisGO:00069358.2CCL11, CCL22, CCL7, CCL17, CXCL11
12inflammatory responseGO:00069548.2CXCL11, CCL17, CCL7, CCL22, CCL11
13immune responseGO:00069558.2CXCL11, CCL17, CCL7, CCL22, CCL11

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080098.0CCL11, CCL22, CCL7, CCL17, CXCL11

Products for genes affiliated with Vernal Keratoconjunctivitis

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Sources for Vernal Keratoconjunctivitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet