MCID: VRN004
MIFTS: 52

Vernal Keratoconjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 50 56
Keratoconjunctivitis, Vernal 69
Keratoconjunctivitis Vernal 52
Spring Catarrh 56
Vkc 50

Characteristics:

Orphanet epidemiological data:

56
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA70476
UMLS via Orphanet 70 C0022577
ICD10 via Orphanet 34 H16.2

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 50 vernal keratoconjunctivitis (vkc) is a chronic, severe allergy that affects the surfaces of the eyes. it most commonly occurs in boys living in warm, dry climates. attacks associated with vkc are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). the condition usually subsides at the onset of puberty. it is caused by a hypersensitivity (allergic reaction) to airborne-allergens. management focuses on preventing "flare ups" and relieving the symptoms of the condition. last updated: 12/7/2011

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to asthma and keratoconjunctivitis, and has symptoms including abnormality of the conjunctiva, abnormality of the sclera and photophobia. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and neutrophil, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 72 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
id Related Disease Score Top Affiliating Genes
1 asthma 26.4 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2 keratoconjunctivitis 11.1
3 papillary follicular thyroid adenocarcinoma 10.7 IL5 RNASE3
4 crustacean allergy 10.6 IL5 RNASE3
5 penis agenesis 10.6 CCL11 IL5
6 subacute bacterial endocarditis 10.6 IL5 RNASE3
7 signet ring cell adenocarcinoma 10.6 IL5 RNASE3
8 skin disease 10.6 IL5 RNASE3
9 orbit alveolar rhabdomyosarcoma 10.5 IL4 IL5
10 angioid streaks of choroid 10.5 IL4 IL5
11 allescheriosis 10.5 IL4 IL5
12 psychotic disorder 10.5 CCL11 IL4
13 histoplasmosis retinitis 10.5 IL4 IL5
14 retinal vascular disease 10.5 CCL11 IL4
15 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.5 IL4 IL5
16 whistling face syndrome, recessive form 10.5 IL5 RNASE3
17 philophthalmiasis 10.5 IL4 IL5
18 vulvar disease 10.5 CCL5 RNASE3
19 ileitis 10.4 ICAM1 IL4
20 cecum adenoma 10.4 MMP9 RNASE3
21 dislocation of ear ossicle 10.4 ICAM1 RNASE3
22 hidradenitis suppurativa 10.4 CCL11 CCL5
23 glioblastoma multiforme 10.4 IL5 RNASE3
24 dissociated nystagmus 10.4 IL4 IL5
25 spindle cell hemangioma 10.4 ICAM1 IL4
26 bardet-biedl syndrome 15 10.4 ICAM1 IL4
27 conjunctivitis 10.4
28 influenza 10.4 CCL11 MMP9
29 lymphocytic gastritis 10.3 CCL11 IL5 RNASE3
30 keratoconus 10.3
31 marasmus 10.3 IL4 IL5 RNASE3
32 nasal cavity carcinoma in situ 10.3 CCL11 IL5 RNASE3
33 x-linked intellectual disability, van esch type 10.3 IL4 IL5 RNASE3
34 orbital plasma cell granuloma 10.3 IL4 IL5 RNASE3
35 allergic conjunctivitis 10.3
36 bartholin's duct cyst 10.3 CCL11 IL5 RNASE3
37 nut allergy 10.3 IL4 IL5 RNASE3
38 epidermolysis bullosa simplex superficialis 10.3 IL4 RNASE3
39 vascular dementia 10.3 CCL5 IL4
40 anterior dislocation of lens 10.3 CCL11 IL4 RNASE3
41 premature ovarian failure 12 10.2 CCL11 IL4 RNASE3
42 keratitis 10.2
43 lipoid nephrosis 10.2 ICAM1 MMP9
44 dermatitis herpetiformis 10.2 CCL5 IL5
45 pyridoxine deficiency 10.2 CXCR3 IL5
46 exophthalmos 10.2 CCL5 IL5 RNASE3
47 cytoplasmic body myopathy 10.2 IL13 IL5
48 gonococcal endophthalmia 10.2 CCL5 IL5
49 dysphagia 10.2 CCL5 ICAM1
50 aortic arch interruption 10.1 IL13 IL5

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

56 32 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the conjunctiva 56 32 hallmark (90%) Very frequent (99-80%) HP:0000502
2 abnormality of the sclera 56 32 hallmark (90%) Very frequent (99-80%) HP:0000591
3 photophobia 56 32 hallmark (90%) Very frequent (99-80%) HP:0000613
4 lacrimation abnormality 56 32 hallmark (90%) Very frequent (99-80%) HP:0000632
5 pruritus 56 32 hallmark (90%) Very frequent (99-80%) HP:0000989
6 corneal neovascularization 56 32 hallmark (90%) Very frequent (99-80%) HP:0011496
7 punctate keratitis 56 32 hallmark (90%) Very frequent (99-80%) HP:0011859
8 allergy 56 32 hallmark (90%) Very frequent (99-80%) HP:0012393
9 scarring 56 32 frequent (33%) Frequent (79-30%) HP:0100699
10 abnormality of the cornea 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 ICAM1 IL13 IL4 IL5 MMP9 CCL11
2 digestive/alimentary MP:0005381 9.65 ICAM1 IL13 IL4 IL5 MMP9
3 immune system MP:0005387 9.56 CXCR3 ICAM1 IL13 IL4 IL5 MMP9
4 respiratory system MP:0005388 9.1 CXCR3 IL13 IL4 IL5 MMP9 CCL11

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
4
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
5
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
6
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
7
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
8 Antiemetics Phase 4
9 Antifungal Agents Phase 4,Phase 3,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2
11 Anti-Inflammatory Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Antirheumatic Agents Phase 4,Phase 3,Phase 2
14 Autonomic Agents Phase 4,Phase 3,Phase 2
15 BB 1101 Phase 4
16 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
17 Cyclosporins Phase 4,Phase 3,Phase 2
18 Dermatologic Agents Phase 4,Phase 3,Phase 2
19 Dexamethasone acetate Phase 4 1177-87-3
20 Gastrointestinal Agents Phase 4
21 glucocorticoids Phase 4
22 HIV Protease Inhibitors Phase 4
23 Hormone Antagonists Phase 4
24 Hormones Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
27 Nasal Decongestants Phase 4,Phase 3,Phase 2
28 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
30 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
31
protease inhibitors Phase 4
32 Respiratory System Agents Phase 4,Phase 3,Phase 2
33 Tetrahydrozoline Phase 4,Phase 3,Phase 2
34 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
35 Anti-Allergic Agents Phase 4,Phase 3
36 Anti-Asthmatic Agents Phase 4
37 Bronchodilator Agents Phase 4
38 Histamine Antagonists Phase 4,Phase 3
39 Histamine H1 Antagonists Phase 4,Phase 3
40
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
41 N-acetyl-1-aspartylglutamic acid Phase 4
42 Neuroprotective Agents Phase 4
43 Neurotransmitter Agents Phase 4,Phase 3
44 Protective Agents Phase 4
45
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
46 Antipruritics Phase 3
47 Acidophilus Nutraceutical Phase 2, Phase 3

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
3 Topical Tacrolimus in Vernal Keratoconjunctivitis Recruiting NCT02456025 Phase 4 Topical tacrolimus
4 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
5 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
6 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
7 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
8 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
9 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
10 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
11 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

39
Eye, Testes, Neutrophil, T Cells, Thyroid

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 324)
id Title Authors Year
1
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
2
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2017
3
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
4
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
5
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
6
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
7
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
8
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
9
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
10
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
11
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
12
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
13
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
14
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
15
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
16
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
17
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
18
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
19
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
20
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
21
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
22
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
23
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
24
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016
25
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
26
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
27
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
28
Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis. ( 26235361 )
2015
29
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis. ( 25756057 )
2015
30
Deep Anterior Lamellar Keratoplasty in Keratoconic Patients with versus without Vernal Keratoconjunctivitis. ( 26425311 )
2015
31
Topographic corneal changes in children with vernal keratoconjunctivitis: A report from Kathmandu, Nepal. ( 26070227 )
2015
32
[Vernal keratoconjunctivitis]. ( 26464371 )
2015
33
Intracellular IL-4, IL-5, and IFN-I^ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis. ( 25999672 )
2015
34
Dry Eye in Vernal Keratoconjunctivitis: A Cross-Sectional Comparative Study. ( 26496269 )
2015
35
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics. ( 25744396 )
2015
36
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? ( 25692810 )
2015
37
Corneal complications of vernal keratoconjunctivitis. ( 26258926 )
2015
38
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. ( 26768065 )
2015
39
In vivo confocal microscopy of meibomian glands and palpebral conjunctiva in vernal keratoconjunctivitis. ( 26044472 )
2015
40
Is there is an association between the presence of Staphylococcus species and occurrence of vernal keratoconjunctivitis? ( 26586974 )
2015
41
Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. ( 25712437 )
2015
42
Alpha-1 antitrypsin, a diagnostic and prognostic marker of vernal keratoconjunctivitis. ( 24995171 )
2014
43
Topical Tacrolimus 0.03% as Sole Therapy in Vernal Keratoconjunctivitis: A Randomized Double-Masked Study. ( 24418865 )
2014
44
Vernal keratoconjunctivitis: a severe allergic eye disease with remodeling changes. ( 24438133 )
2014
45
Pathogenesis of Vernal Keratoconjunctivitis and Associated Factors. ( 24571721 )
2014
46
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. ( 25410033 )
2014
47
Images in clinical medicine. Giant papillae in vernal keratoconjunctivitis. ( 24758619 )
2014
48
Effect of Vernal Keratoconjunctivitis on Vitreous Depth in Patients with Keratoconus. ( 24409941 )
2014
49
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. ( 25140177 )
2014
50
Efficacy of topical 0.05% cyclosporine treatment in children with severe vernal keratoconjunctivitis. ( 25818961 )
2014

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.45 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.33 CCL11 CCL5 ICAM1 IL13 IL4 IL5
4
Show member pathways
13.2 CCL11 CCL5 CXCR3 ICAM1 MMP9
5
Show member pathways
13.2 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.15 CCL11 CCL5 ICAM1 IL13 IL4 IL5
7
Show member pathways
13.09 CCL11 CCL5 CXCR3 IL13 IL4 IL5
8
Show member pathways
12.62 CCL5 ICAM1 IL13 IL4
9
Show member pathways
12.62 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10
Show member pathways
12.17 CCL11 CCL5 ICAM1
11
Show member pathways
12.1 CCL11 IL13 IL4 IL5 MMP9
12
Show member pathways
12.05 IL13 IL4 IL5
13
Show member pathways
12 IL13 IL4 IL5
14 11.86 ICAM1 IL4 MMP9
15
Show member pathways
11.86 CCL11 CCL5 CXCR3
16 11.8 CCL5 ICAM1 MMP9
17 11.69 ICAM1 IL13 IL4 IL5
18 11.66 CXCR3 IL13 IL4 IL5
19 11.59 ICAM1 IL4 IL5
20 11.53 CCL11 IL4 IL5
21 11.41 CCL11 ICAM1 IL13 IL4 MMP9
22 11.26 CCL5 MMP9
23 11.25 CCL5 ICAM1 IL13 IL4
24 11.22 IL13 IL4 IL5
25 11.19 CCL11 CXCR3
26 11.18 IL13 IL4 IL5
27 11.17 IL4 IL5
28 11.14 CCL5 MMP9
29 11.13 CCL11 IL13 IL4 IL5
30 11.1 IL13 IL4 IL5
31 11.04 ICAM1 MMP9
32 10.95 CCL11 CCL5 IL13 IL4 IL5
33 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
34 10.85 CCL5 MMP9
35 10.79 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 external side of plasma membrane GO:0009897 9.26 CXCR3 ICAM1 IL13 IL4
3 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.92 CCL11 CCL5 ICAM1 IL5
2 positive regulation of cell migration GO:0030335 9.79 CCL11 CCL5 MMP9
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 CCL11 CCL5 ICAM1
4 cellular response to tumor necrosis factor GO:0071356 9.74 CCL11 CCL5 ICAM1
5 response to ethanol GO:0045471 9.73 ICAM1 IL13 IL4
6 immune response GO:0006955 9.72 CCL11 CCL5 IL13 IL4 IL5
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 ICAM1 IL4 IL5
8 cellular response to interleukin-1 GO:0071347 9.67 CCL11 CCL5 ICAM1
9 chemokine-mediated signaling pathway GO:0070098 9.65 CCL11 CCL5 CXCR3
10 monocyte chemotaxis GO:0002548 9.62 CCL11 CCL5
11 cellular response to interferon-gamma GO:0071346 9.61 CCL11 CCL5 ICAM1
12 leukocyte cell-cell adhesion GO:0007159 9.6 CCL5 ICAM1
13 innate immune response in mucosa GO:0002227 9.59 IL4 RNASE3
14 positive regulation of JAK-STAT cascade GO:0046427 9.58 CCL5 IL5
15 microglial cell activation GO:0001774 9.58 IL13 IL4
16 positive regulation of mast cell degranulation GO:0043306 9.55 IL13 IL4
17 positive regulation of immunoglobulin production GO:0002639 9.54 IL13 IL4
18 eosinophil chemotaxis GO:0048245 9.52 CCL11 CCL5
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 CCL5 IL4
20 chemotaxis GO:0006935 9.46 CCL11 CCL5 CXCR3 IL4
21 positive regulation of B cell proliferation GO:0030890 9.43 IL13 IL4 IL5
22 regulation of proton transport GO:0010155 9.4 IL13 IL4
23 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
24 negative regulation of endothelial cell apoptotic process GO:2000352 9.13 ICAM1 IL13 IL4
25 inflammatory response GO:0006954 9.02 CCL11 CCL5 CXCR3 IL13 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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