MCID: VRR004
MIFTS: 52

Verrucous Carcinoma malady

Cancer diseases category
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Summaries for Verrucous Carcinoma

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Disease Ontology:8 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards based summary: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to papilloma and epidermolysis bullosa simplex. An important gene associated with Verrucous Carcinoma is MIR125A (microRNA 125a), and among its related pathways are Glucocorticoid receptor regulatory network and ErbB signaling pathway. The compounds dutp and p00001 have been mentioned in the context of this disorder. Affiliated tissues include cervix, bone and skin, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Wikipedia:65 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 44Novoseek, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Verrucous Carcinoma, Aliases & Descriptions:

Name: Verrucous Carcinoma 8 10 62
Verrucous Squamous Cell Carcinoma 8 62
Verrucous Squamous Carcinoma 8 62
Condylomatous Carcinoma 62
 
Verrucous Carcinoma Nos 8
Carcinoma Verrucous 44
Warty Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3737
MeSH34 D018289
NCIt39 C3781

Related Diseases for Verrucous Carcinoma

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Diseases related to Verrucous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma31.0KRT5, KRT10
2epidermolysis bullosa simplex30.3KRT10, KRT5
3oral cancer30.2KRT5, MDM2
4adenocarcinoma29.4ERBB3, KRT5, TYMP, KRT10, MDM2
5bladder verrucous squamous cell carcinoma10.5
6oral squamous cell carcinoma10.5
7cervical verrucous carcinoma10.4
8larynx verrucous carcinoma10.4
9epidermolytic hyperkeratosis10.4KRT10
10lichen planus10.4
11subglottis verrucous carcinoma10.4
12supraglottis verrucous carcinoma10.4
13vulva verrucous carcinoma10.4
14esophagus verrucous carcinoma10.4
15glottis verrucous carcinoma10.4
16penis non-invasive verrucous carcinoma10.4
17cervicitis10.4
18sinusitis10.3
19urethral verrucous carcinoma10.3
20balanitis10.3
21esophagitis10.3
22inverted papilloma10.3
23laryngitis10.3
24burn scar10.2
25burns10.2
26oral submucous fibrosis10.2
27in situ carcinoma10.2
28osteomyelitis10.2
29penis verrucous carcinoma10.2
30schistosomiasis10.2
31buschke lowenstein tumor10.2
32leukoplakia10.2
33lichen sclerosus10.2
34oral lichen planus10.2
35cervical squamous cell carcinoma10.2KRT10, TYMP
36palmoplantar keratosis10.2KRT10, KRT5
37nonepidermolytic palmoplantar keratoderma10.1KRT5, KRT10
38grade iii astrocytoma10.1TYMP, MDM2
39esophageal cancer10.1TYMP, MDM2
40bladder carcinoma10.1TYMP, MDM2
41diabetic neuropathy10.1
42hepatitis10.1
43peripheral t-cell lymphoma10.1
44hidradenitis suppurativa10.1
45ankylosis10.1
46hepatitis c10.1
47urinary schistosomiasis10.1
48plantar wart10.1
49gout10.1
50syringocystadenoma papilliferum10.1

Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Symptoms for Verrucous Carcinoma

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Drugs & Therapeutics for Verrucous Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

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Anatomical Context for Verrucous Carcinoma

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MalaCards organs/tissues related to Verrucous Carcinoma:

32
Cervix, Bone, Skin, T cells, Tongue, Lymph node, Smooth muscle, Colon, Breast, Testes, Neutrophil

Animal Models for Verrucous Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Verrucous Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MDM2, KRT10, ERBB3
2MP:00053718.6KRT10, KRT5, MDM2
3MP:00107718.0MDM2, KRT5, KRT10, ERBB3

Publications for Verrucous Carcinoma

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Articles related to Verrucous Carcinoma:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma. (25214794)
2014
2
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
3
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
4
Stereology study of oral verrucous carcinoma. (22740216)
2012
5
Penile verrucous carcinoma arising in HPV-negative condylomatous papules. (21524989)
2011
6
Carcinoma cunniculatum on the shoulder: an atypical localisation of a verrucous carcinoma. (18289952)
2009
7
Verrucous carcinoma of the foot: a case report. (18725683)
2008
8
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
9
Cytology of uterine cervical verrucous carcinoma. (18936012)
2008
10
Oral and maxillofacial pathology case of the month. Verrucous carcinoma. (18717430)
2008
11
Verrucous carcinoma (Buschke-Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case. (17609975)
2008
12
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
13
Verrucous carcinoma of the cervix: detection of carcinogenetic human papillomavirus types and their role during follow-up. (18214065)
2007
14
Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation. (17197212)
2007
15
Verrucous carcinoma of the scalp. (17141366)
2007
16
Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features. (17032398)
2006
17
Verrucous carcinoma of the vulva in Turner syndrome. (14751191)
2004
18
Cytomorphology of verrucous carcinoma of the cervix. A case report. (14674078)
2003
19
Eyelid verrucous carcinoma. (12474928)
2002
20
Verrucous carcinoma of the renal pelvis. (11445495)
2001
21
Verrucous carcinoma of the uterine cervix. (11076434)
2000
22
Oral verrucous carcinoma. (10102583)
1999
23
Plantar verrucous carcinoma following transmetatarsal amputation and renal transplantation. (9600438)
1998
24
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
25
Verrucous carcinoma or epithelioma cuniculatum plantare. (9066754)
1997
26
Verrucous carcinoma of the vulva. (9141857)
1996
27
Clinical pathology case conference. Verrucous carcinoma. (9552636)
1996
28
Verrucous carcinoma of the larynx. (7816455)
1995
29
Verrucous carcinoma of the lip originating on the vermilion border. (8002160)
1994
30
Demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. (8391880)
1993
31
Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction. (17431983)
1993
32
Verrucous carcinoma of the oesophagus and achalasia. (8439656)
1993
33
Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. (1586504)
1992
34
Verrucous carcinoma (Buschke-Lowenstein tumor). (1659557)
1991
35
Management of verrucous carcinoma of the larynx. (2070533)
1991
36
Penile verrucous carcinoma. (2396837)
1990
37
The therapy of verrucous carcinoma of the vulva. Observations on three cases. (2776786)
1989
38
Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. (2757559)
1989
39
A clinico-pathologic presentation. Verrucous carcinoma. (3473171)
1987
40
Verrucous carcinoma of the maxilla in a thirteen-year-old male. (3937104)
1985
41
Verrucous carcinoma of the uterine cervix. A case report. (6578652)
1983
42
Verrucous carcinoma of the penis (Buschke-Lowenstein tumour): a clinico-pathological study. (6883049)
1983
43
Verrucous carcinoma of the cervix uteri: report of a case. (6942625)
1981
44
Management of verrucous carcinoma on a foot by a combination of chemosurgery and plastic repair: report of a case. (7391328)
1980
45
Verrucous lesions of the female genitalia. II. Verrucous carcinoma. (7386524)
1980
46
Verrucous carcinoma of the oral cavity: management by radiotherapy and surgery. (7363153)
1980
47
Verrucous carcinoma of the cervix and endometrium. (7439016)
1980
48
Verrucous carcinoma of the vagina. (635607)
1978
49
Hemoptysis and supraglottic verrucous carcinoma. (891429)
1977
50
Ineffectiveness of bleomycin in verrucous carcinoma of the vulva. (95665)
1975

Variations for Verrucous Carcinoma

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Expression for genes affiliated with Verrucous Carcinoma

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Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

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Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, KRT5
2
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.1MDM2, ERBB3
3
Show member pathways
9.1MDM2, ERBB3
49.1ERBB3, MDM2
59.1MDM2, ERBB3
68.7MDM2, ERBB3, MIR125A
7
Show member pathways
Signaling Pathways in Glioblastoma37
8.6MDM2, ERBB3, TYMP

Compounds for genes affiliated with Verrucous Carcinoma

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Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dutp449.9MDM2, KRT10
2p00001449.8TYMP, MDM2
3ifosfamide44 1110.8MDM2, TYMP
4calcipotriol44 61 28 1112.8KRT5, KRT10
5vinblastine44 50 1111.8TYMP, MDM2
6irinotecan44 50 1111.7TYMP, MDM2
7mitomycin c449.7TYMP, MDM2
8p003449.7MDM2, TYMP
9benzo(a)pyrene449.7MDM2, KRT5
10lead449.6TYMP, MDM2
11nucleoside449.6MDM2, TYMP
12thymidylate449.5TYMP, MDM2
13vincristine44 50 1111.5MDM2, TYMP
14erlotinib44 50 1111.5ERBB3, TYMP
15trastuzumab44 50 1111.5MDM2, ERBB3
16gefitinib44 50 1111.4MDM2, ERBB3
17cyclophosphamide44 50 1111.4MDM2, TYMP
18gemcitabine44 50 1111.4ERBB3, TYMP
19glyceraldehyde 3-phosphate449.4MDM2, KRT10, TYMP
20proline449.2KRT10, KRT5, MDM2
21docetaxel44 50 61 1112.1MDM2, TYMP
22p002449.0TYMP, ERBB3, MDM2
23arginine449.0MDM2, KRT5, KRT10
24ly294002449.0TYMP, ERBB3, MDM2
25wortmannin449.0MDM2, ERBB3, TYMP
26doxorubicin44 50 1111.0MDM2, ERBB3, TYMP
27estradiol44 24 1111.0TYMP, ERBB3, MDM2
28steroid449.0MDM2, KRT10, ERBB3
29fatty acid448.9ERBB3, KRT10, KRT5
30genistein44 28 61 2 24 1113.9MDM2, KRT5, ERBB3
31vegf448.8MDM2, ERBB3, TYMP
32testosterone44 61 24 1111.8MDM2, KRT5, ERBB3
33threonine448.5ERBB3, KRT10, KRT5, MDM2
34alanine448.4ERBB3, KRT5, MDM2
35calcium44 50 24 1111.1MDM2, KRT5, KRT10, ERBB3
36paraffin448.0MDM2, KRT5, KRT10, ERBB3, TYMP
37progesterone44 28 61 24 1112.0TYMP, ERBB3, KRT10, KRT5, MDM2
38estrogen448.0MDM2, KRT5, KRT10, ERBB3, TYMP
39serine447.9MDM2, KRT5, KRT10, ERBB3, TYMP
40tyrosine447.9TYMP, ERBB3, KRT10, KRT5, MDM2

GO Terms for genes affiliated with Verrucous Carcinoma

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Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT5, KRT10
2keratin filamentGO:0450959.1KRT5, KRT10

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:0085439.1MDM2, ERBB3
2phosphatidylinositol-mediated signalingGO:0480158.8MDM2, ERBB3

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.3MDM2, KRT5

Products for genes affiliated with Verrucous Carcinoma

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Sources for Verrucous Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet