MCID: VRR004
MIFTS: 58

Verrucous Carcinoma malady

Cancer diseases category

Summaries for Verrucous Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to squamous cell carcinoma and papilloma. An important gene associated with Verrucous Carcinoma is KRT10 (keratin 10), and among its related pathways are GPCR Pathway and AKT phosphorylates targets in the cytosol. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and bone, and related mouse phenotypes are homeostasis/metabolism and embryogenesis.

Wikipedia:63 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

verrucous carcinoma 8 10 60
verrucous squamous cell carcinoma 8
verrucous squamous carcinoma 8
condylomatous carcinoma 60
verrucous carcinoma nos 8
carcinoma verrucous 44
warty carcinoma 8


External Ids:

Disease Ontology8 DOID:3737
NCIt39 C3781
MeSH34 D018289

Related Diseases for Verrucous Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Verrucous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.0CCND1, CD44, CDH1, TGFA
2papilloma30.7RB1, CDKN2A, CDKN1A, KRT10, TGFA
3bladder carcinoma30.7MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
4lichen planus30.5KRT10
5laryngeal squamous cell carcinoma30.3CD44, CDH1, CDKN1A, CDKN2A, RB1, CCND1
6keratoacanthoma30.2KRT10, CDKN1A
7endometrial carcinoma30.2CDH1, CDKN2A, TYMP
8adenocarcinoma30.2CDKN2A, TYMP, RB1, MDM2, CCND1, CD44
9hepatitis30.0TYMP
10keratosis30.0KRT10
11psoriasis30.0TGFA, KRT10
12meningioma30.0MSN, TGFA
13hepatitis c30.0TYMP, HSPA4
14cervical adenocarcinoma30.0CDKN2A, CDKN1A
15nasopharynx carcinoma30.0CDKN2A, CDH1
16colon adenocarcinoma30.0CDH1, CDKN1A, TGFA
17bladder carcinoma in situ30.0CDH1, CDKN2A, CCND1
18renal clear cell carcinoma29.9TGFA, CDH1
19larynx verrucous carcinoma10.8
20vulva verrucous carcinoma10.7
21esophagus verrucous carcinoma10.6
22penis verrucous carcinoma10.6
23bone carcinoma10.5
24verrucous papilloma10.5
25cervical verrucous carcinoma10.4
26bladder verrucous squamous cell carcinoma10.4
27glottis verrucous carcinoma10.3
28in situ carcinoma10.3
29penis non-invasive verrucous carcinoma10.3
30subglottis verrucous carcinoma10.3
31supraglottis verrucous carcinoma10.3
32cervicitis10.3
33urethral verrucous carcinoma10.2
34balanitis10.2
35esophagitis10.2
36inverted papilloma10.2
37laryngeal carcinoma10.2
38laryngitis10.2
39burn scar10.1
40burns10.1
41oral submucous fibrosis10.1
42oral mucosa leukoplakia10.1
43skin carcinoma in situ10.1
44middle ear carcinoma10.1
45osteomyelitis10.1
46renal cell carcinoma10.1
47renal pelvis carcinoma10.1
48schistosomiasis10.1
49scrotal carcinoma10.1
50skin squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Clinical Features for Verrucous Carcinoma

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Drugs & Therapeutics for Verrucous Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Verrucous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Search CenterWatch for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

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Anatomical Context for Verrucous Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Verrucous Carcinoma:

32
Cervix, Skin, Bone, Tongue, T cells, Lymph node, Breast, Colon

Animal Models for Verrucous Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Verrucous Carcinoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2ACOT13, PISD
2MP:000538010.1ERBB3, PISD
3MP:00053919.9TGFA
4MP:00053909.9CCND1, RB1, CD44, CDKN1A, TGFA
5MP:00053799.8HSPA4, CCND1, RB1, CDKN2A, CD44, CDKN1A
6MP:00053699.7MDM2, RB1, CDKN2A, CDKN1A, ERBB3, TGFA
7MP:00053899.7CCND1, CDKN2A, CD44, CDH1, CDKN1A, TGFA
8MP:00036319.7HSPA4, TYMP, CDKN1A, NOS2, ERBB3
9MP:00053889.6CCND1, RB1, CD44, CDKN1A, ERBB3
10MP:00053829.5CCND1, MDM2, RB1, CDKN1A, KRT10, NOS2
11MP:00107719.5CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A
12MP:00053709.5MDM2, RB1, CDKN2A, CD44, CDKN1A, NOS2
13MP:00020069.3CDKN2A, RB1, MDM2, CCND1, CD44, CDH1
14MP:00053859.1CCND1, MDM2, RB1, CD44, CDH1, CDKN1A
15MP:00053869.0HSPA4, CCND1, MDM2, RB1, CDKN2A, CD44
16MP:00053819.0TGFA, CCND1, MDM2, RB1, CDKN2A, CD44
17MP:00053878.9CCND1, MDM2, RB1, TYMP, CDKN2A, CD44
18MP:00053848.8HSPA4, CCND1, MDM2, PISD, RB1, TYMP
19MP:00107688.7HSPA4, CCND1, MDM2, PISD, RB1, CDKN2A
20MP:00053788.6CDKN2A, RB1, PISD, MDM2, CCND1, CD44

Publications for Verrucous Carcinoma

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50PubMed
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Articles related to Verrucous Carcinoma:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: case report and clinical update. (24170467)
2013
2
Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour? (24350715)
2013
3
Subset of patients with verrucous carcinoma of the oral cavity who benefit from treatment with methotrexate. (22000636)
2012
4
Maxillary verrucous carcinoma coincident with cervical lymph node metastasis of colon adenocarcinoma. (23113859)
2012
5
Surgical treatment for 11 cases of penile verrucous carcinoma. (22346275)
2011
6
Treatment of verrucous carcinoma of the lower lip with topical imiquimod (aldaraAr) and debulking therapy. (22028577)
2011
7
Oral pathology quiz #69. Case number 1. Verrucous carcinoma. (21338034)
2010
8
Temporal bone verrucous carcinoma: outcomes and treatment controversy. (21225767)
2010
9
Oral verrucous carcinoma treated with carbon dioxide laser. (20028445)
2010
10
Immunohistochemical expression of basement membrane proteins of verrucous carcinoma of the oral mucosa. (19506920)
2010
11
Oral and maxillofacial pathology case of the month. Verrucous carcinoma. (18717430)
2008
12
Case of the month. Verrucous carcinoma. (18335619)
2008
13
Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. (18223526)
2008
14
Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation. (17197212)
2007
15
Verrucous carcinoma of the temporal bone and maxillary antrum: two unusual presentations of a rare tumor. (17028455)
2006
16
Verrucous carcinoma of the cervix--diagnostic and therapeutic difficulties with regards to HPV status. Case report. (15857039)
2005
17
Diagnostic utility of cell cycle and apoptosis regulatory proteins in verrucous squamous carcinoma. (15894931)
2005
18
Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy. (15752262)
2005
19
Prevalence of human papillomavirus DNA sequences in verrucous carcinoma of the lip: genomic and therapeutic approaches. (15863262)
2005
20
Verrucous carcinoma of the vulva in Turner syndrome. (14751191)
2004
21
Verrucous carcinoma of the skin: long-term follow-up results following surgical therapy. (15274703)
2004
22
Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. (14969824)
2004
23
Periungual keratoacanthoma preceded by a wart and followed by a verrucous carcinoma at the same site. (12816167)
2003
24
Verrucous carcinoma of the penis treated with cryosurgery. (12187233)
2002
25
Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. (10226946)
1999
26
Transforming growth factor beta receptors in verrucous and squamous cell carcinoma. (10448730)
1999
27
Case presentation. Verrucous carcinoma. (10613145)
1998
28
Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck? (9578870)
1998
29
Penile verrucous carcinoma in a 37-year-old circumcised man. (9270540)
1997
30
Verrucous carcinoma of the larynx. (7816455)
1995
31
Radiotherapy in the treatment of verrucous carcinoma of the head and neck. (7715385)
1995
32
Laryngeal verrucous carcinoma: a clinicopathologic study and detection of human papillomavirus using polymerase chain reaction. (8302116)
1994
33
Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. (8030818)
1994
34
Verrucous carcinoma of the bilharzial bladder. Impact of invasiveness on survival. (8351470)
1993
35
Verrucous carcinoma of the larynx: role of human papillomavirus, radiation, and surgery. (8382761)
1993
36
Verrucous carcinoma (Buschke-Lowenstein tumor). (1659557)
1991
37
Buschke-LAPwenstein tumor: verrucous carcinoma of the anogenitalia. (2070647)
1991
38
Intravesical condyloma acuminatum with progression to verrucous carcinoma. (2238308)
1990
39
Plantar verrucous carcinoma (epithelioma cuniculatum): case report with review of the literature. (3511327)
1986
40
Verrucous carcinoma of the larynx. Possible human papillomavirus etiology. (2996475)
1985
41
A case of verrucous carcinoma of the uterine cervix: clinical, light, and electron microscopic, and immunohistological observations. (2996996)
1985
42
The discriminatory diagnostic ability of beta 2-microglobulin labelling in viral warts, pseudoepitheliomatous hyperplasia and verrucous carcinoma of the skin. (3891162)
1985
43
Verrucous carcinoma of the skin and its management by Mohs' surgery. (6701219)
1984
44
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide. (6440408)
1984
45
Verrucous carcinoma and verrucous hyperplasia. (6964202)
1982
46
Verrucous carcinoma. Report of a case with electron microscopy studies. (6811631)
1982
47
Verrucous carcinoma of the oral cavity. (6757186)
1982
48
Carcinoma cuniculatum (verrucous carcinoma of the skin): a clinicopathologic study of 46 cases with ultrastructural observations. (7042070)
1982
49
Perineural invasion and anaplastic transformation of verrucous carcinoma. (4353014)
1973
50
Pigmented basal-cell carcinoma in verrucous nevi. Report of 2 cases. (13785794)
1961

Genetic Variations for Verrucous Carcinoma

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Expression for genes affiliated with Verrucous Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

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Sources:
51QIAGEN, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB3
210.2CDKN1A, MDM2
310.1MDM2, CDKN1A, ERBB3
4
Hide members
10.0CDKN1A, MDM2, CCND1
5
Transcription Androgen Receptor nuclear signaling
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10.0CCND1, MDM2, CDKN1A
610.0CCND1, MDM2, CDKN1A
710.0MDM2, CDKN2A, CDKN1A
810.0MDM2, CDH1, ERBB3
910.0MDM2, RB1, CDKN1A
1010.0MDM2, RB1, CDKN2A
1110.0NOS2, RB1, CCND1
129.9CCND1, RB1, TGFA
13
Cell adhesion ECM remodeling
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9.9CD44, CDH1, MSN
14
Hide members
9.9CDKN1A, RB1, MDM2, CCND1
15
Hide members
9.9CCND1, MDM2, RB1, CDKN1A
169.9CDKN1A, RB1, MDM2, CCND1
17
Transcription P53 signaling pathway
Hide members
9.9MDM2, RB1, CDKN2A, CDKN1A
18
Hide members
9.9CCND1, MDM2, CDH1, CDKN1A
199.9CCND1, RB1, CDKN2A, CDKN1A
20
Hide members
9.9CCND1, RB1, CDKN2A, CDKN1A
21
Cell cycle Cell cycle (generic schema)
Hide members
9.9CCND1, RB1, CDKN2A, CDKN1A
229.9CCND1, MDM2, RB1, CDH1
239.9CDKN1A, CD44, RB1, MDM2
249.8CCND1, RB1, CD44, CDKN1A
25
Hide members
9.8NOS2, CDKN1A, RB1, CCND1
269.8TGFA, CDKN1A, RB1, MDM2
279.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
289.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
29
Hide members
9.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
30
Hide members
9.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
31
Hide members
9.7CDKN1A, CDKN2A, RB1, MDM2, CCND1
32
Hide members
9.7CCND1, MDM2, CDKN2A, CD44, CDKN1A
33
Hide members
9.7MDM2, RB1, CDKN2A, CDH1, CDKN1A
349.7MDM2, RB1, CDKN2A, CD44, CDKN1A
35
Hide members
9.7CCND1, MDM2, CDKN1A, ERBB3, TGFA
36
Hide members
9.7TGFA, ERBB3, CDKN1A, MDM2, CCND1
379.6CCND1, MDM2, CDKN2A, CD44, CDKN1A, ERBB3
38
Hide members
9.5TGFA, MDM2, RB1, TYMP, CDKN1A, ERBB3
399.5CCND1, MDM2, CD44, CDKN1A, MSN, ERBB3
40
Hide members
9.5CCND1, MDM2, RB1, CDKN2A, CDKN1A, TGFA
41
Hide members
9.5MDM2, RB1, CDKN2A, CD44, ERBB3, TGFA
42
Hide members
9.5HSPA4, CCND1, MDM2, RB1, CDH1, CDKN1A
439.1CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A
44
Hide members
9.0CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A

Compounds for genes affiliated with Verrucous Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7MSN
2resveratrol44 59 11 2413.7TGFA
3cycloheximide4410.6MSN, TYMP
4vincristine44 49 1112.4CCND1, RB1, TYMP
5serine4410.4CDH1, CCND1, CD44
6depsipeptide4410.3CCND1, CDKN2A, CDH1
7estradiol44 11 2412.2ERBB3, RB1, MDM2
8olomoucine44 1111.1CDKN1A, CCND1, RB1, CDKN2A
9crcs4410.1CDH1, CCND1, RB1, TYMP, CDKN2A
10roscovitine4410.0CDKN2A, CDKN1A, RB1, MDM2, CCND1
11erlotinib44 49 1112.0CDH1, ERBB3, TGFA, TYMP, CCND1
12p000014410.0CDH1, CD44, CDKN2A, TYMP, MDM2, CCND1
13irinotecan44 49 1112.0CDH1, CDKN2A, TYMP, CDKN1A, MDM2
14p002449.9MDM2, RB1, CD44, CDH1, ERBB3, TYMP
15gefitinib44 49 1111.9CCND1, TGFA, ERBB3, CDKN1A, CDH1, MDM2
16flavopiridol44 1110.9CCND1, CDKN2A, CDKN1A, MDM2, RB1, HSPA4
17thymidylate449.8CDKN1A, CCND1, MDM2, RB1, TYMP, CDKN2A
18adpribose449.8MDM2, HSPA4, CDKN1A, CCND1, RB1
19formaldehyde44 2410.8CCND1, TGFA, RB1, CDH1, CD44, TYMP
20gemcitabine44 49 1111.7TYMP, ERBB3, CDKN1A, CCND1, HSPA4
21geldanamycin44 49 59 1112.7CDKN1A, MDM2, CCND1, HSPA4, CDH1
22dexamethasone44 49 28 1112.7SPRR1B, CDH1, CDKN2A, RB1, HSPA4, MDM2
23curcumin449.7NOS2, CDKN1A, CCND1, CDH1, MDM2, HSPA4
24methotrexate44 49 1111.7CDKN2A, CDH1, TYMP, CCND1, RB1, MDM2
25calcitriol44 59 11 2412.7RB1, KRT10, CD44, TGFA, CDH1, CDKN1A
26mg 13244 5910.7CDH1, CCND1, CDKN1A, HSPA4, MDM2, NOS2
27bromodeoxyuridine449.7HSPA4, CD44, RB1, CDKN1A, KRT10, TGFA
28rapamycin449.6TGFA, CDKN1A, MDM2, RB1, CDH1, ERBB3
29etoposide44 49 59 1112.6MDM2, RB1, CD44, CDH1, TGFA
30cisplatin44 49 59 1112.6MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
31adriamycin449.6CDH1, CDKN1A, CD44, CDKN2A, RB1, MDM2
32steroid449.5CDKN2A, CCND1, RB1, CD44, KRT10, ERBB3
335fluorouracil449.5HSPA4, TGFA, CDKN1A, CDH1, TYMP, RB1
34pd 98,059449.5CDH1, MDM2, RB1, TGFA, CCND1, HSPA4
35tamoxifen44 49 28 1112.5CDH1, TGFA, ERBB3, CDKN1A, CD44, TYMP
36paclitaxel44 49 1111.5CDKN2A, CDH1, CD44, RB1, CDKN1A, TYMP
37paraffin449.5HSPA4, CDH1, CDKN1A, ERBB3, TGFA, CD44
38p003449.4MDM2, CDH1, CD44, TYMP, RB1
39agar449.4TGFA, HSPA4, CCND1, CDKN1A, CDH1, CDKN2A
40matrigel449.4CDH1, TGFA, CD44, CCND1, TYMP, RB1
41actinomycin d449.3RB1, TYMP, MDM2, HSPA4, TGFA, NOS2
42testosterone44 59 11 2412.3RB1, CD44, CDKN2A, ERBB3, MDM2, CCND1
43genistein44 28 59 2 11 2414.2HSPA4, CCND1, MDM2, RB1, CDKN2A, CDKN1A
44oligonucleotide449.1TGFA, ERBB3, MSN, CCND1, MDM2, CDKN1A
45ly294002449.1CDH1, HSPA4, CCND1, MDM2, RB1, TYMP
46retinoic acid44 2410.0CDKN1A, CDH1, CD44, CDKN2A, CCND1, HSPA4
47progesterone44 59 28 11 2413.0CCND1, CDKN2A, CD44, CDH1, CDKN1A, MDM2
48doxorubicin44 49 1110.9NOS2, CDKN1A, CDH1, ERBB3, TGFA, CD44
49vegf448.9CDKN1A, CDH1, NOS2, ERBB3, HSPA4, CD44
50tyrosine448.9MSN, TGFA, TYMP, ERBB3, RB1, CD44

GO Terms for genes affiliated with Verrucous Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.2CDKN1A, CCND1
2basolateral plasma membraneGO:0163239.3TGFA, ERBB3, MSN, CDH1, CD44

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to magnesium ionGO:03202610.2MDM2, CCND1
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.2CD44, MDM2
3keratinocyte differentiationGO:03021610.1SPRR1B, SPRR3, KRT10
4wound healingGO:04206010.0ERBB3, SPRR3, TGFA
5epidermal growth factor receptor signaling pathwayGO:00717310.0MDM2, CDKN1A, ERBB3, TGFA
6Ras protein signal transductionGO:0072659.9RB1, CDKN2A, CDKN1A
7response to iron ionGO:0100399.9MDM2, CCND1
8response to drugGO:0424939.8TGFA, CDKN1A, CDH1, MDM2, CCND1

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1A, CDKN2A

Products for genes affiliated with Verrucous Carcinoma

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  • Antibodies
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Sources for Verrucous Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet