MCID: VRR004
MIFTS: 58

Verrucous Carcinoma malady

Cancer diseases category

Summaries for Verrucous Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to squamous cell carcinoma and papilloma. An important gene associated with Verrucous Carcinoma is KRT10 (keratin 10), and among its related pathways are GPCR Pathway and AKT phosphorylates targets in the cytosol. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and bone, and related mouse phenotypes are homeostasis/metabolism and embryogenesis.

Wikipedia:63 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

verrucous carcinoma 8 10 60
verrucous squamous cell carcinoma 8
verrucous squamous carcinoma 8
condylomatous carcinoma 60
verrucous carcinoma nos 8
carcinoma verrucous 44
warty carcinoma 8


External Ids:

Disease Ontology8 DOID:3737
NCIt39 C3781
MeSH34 D018289

Related Diseases for Verrucous Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Verrucous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.0CCND1, CD44, CDH1, TGFA
2papilloma30.7RB1, CDKN2A, CDKN1A, KRT10, TGFA
3bladder carcinoma30.7MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
4lichen planus30.5KRT10
5laryngeal squamous cell carcinoma30.3CD44, CDH1, CDKN1A, CDKN2A, RB1, CCND1
6keratoacanthoma30.2KRT10, CDKN1A
7endometrial carcinoma30.2CDH1, CDKN2A, TYMP
8adenocarcinoma30.2CDKN2A, TYMP, RB1, MDM2, CCND1, CD44
9hepatitis30.0TYMP
10keratosis30.0KRT10
11psoriasis30.0TGFA, KRT10
12meningioma30.0MSN, TGFA
13hepatitis c30.0TYMP, HSPA4
14cervical adenocarcinoma30.0CDKN2A, CDKN1A
15nasopharynx carcinoma30.0CDKN2A, CDH1
16colon adenocarcinoma30.0CDH1, CDKN1A, TGFA
17bladder carcinoma in situ30.0CDH1, CDKN2A, CCND1
18renal clear cell carcinoma29.9TGFA, CDH1
19larynx verrucous carcinoma10.8
20vulva verrucous carcinoma10.7
21esophagus verrucous carcinoma10.6
22penis verrucous carcinoma10.6
23bone carcinoma10.5
24verrucous papilloma10.5
25cervical verrucous carcinoma10.4
26bladder verrucous squamous cell carcinoma10.4
27glottis verrucous carcinoma10.3
28in situ carcinoma10.3
29penis non-invasive verrucous carcinoma10.3
30subglottis verrucous carcinoma10.3
31supraglottis verrucous carcinoma10.3
32cervicitis10.3
33urethral verrucous carcinoma10.2
34balanitis10.2
35esophagitis10.2
36inverted papilloma10.2
37laryngeal carcinoma10.2
38laryngitis10.2
39burn scar10.1
40burns10.1
41oral submucous fibrosis10.1
42oral mucosa leukoplakia10.1
43skin carcinoma in situ10.1
44middle ear carcinoma10.1
45osteomyelitis10.1
46renal cell carcinoma10.1
47renal pelvis carcinoma10.1
48schistosomiasis10.1
49scrotal carcinoma10.1
50skin squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Clinical Features for Verrucous Carcinoma

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Drugs & Therapeutics for Verrucous Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Verrucous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Search CenterWatch for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

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Anatomical Context for Verrucous Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Verrucous Carcinoma:

32
Cervix, Skin, Bone, T cells, Tongue, Lymph node, Colon, Breast

Animal Models for Verrucous Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Verrucous Carcinoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2ACOT13, PISD
2MP:000538010.1ERBB3, PISD
3MP:00053919.9TGFA
4MP:00053909.9CCND1, RB1, CD44, CDKN1A, TGFA
5MP:00053799.8HSPA4, CCND1, RB1, CDKN2A, CD44, CDKN1A
6MP:00053699.7MDM2, RB1, CDKN2A, CDKN1A, ERBB3, TGFA
7MP:00053899.7CCND1, CDKN2A, CD44, CDH1, CDKN1A, TGFA
8MP:00036319.7HSPA4, TYMP, CDKN1A, NOS2, ERBB3
9MP:00053889.6CCND1, RB1, CD44, CDKN1A, ERBB3
10MP:00053829.5CCND1, MDM2, RB1, CDKN1A, KRT10, NOS2
11MP:00107719.5CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A
12MP:00053709.5MDM2, RB1, CDKN2A, CD44, CDKN1A, NOS2
13MP:00020069.3CDKN2A, RB1, MDM2, CCND1, CD44, CDH1
14MP:00053859.1CCND1, MDM2, RB1, CD44, CDH1, CDKN1A
15MP:00053869.0HSPA4, CCND1, MDM2, RB1, CDKN2A, CD44
16MP:00053819.0TGFA, CCND1, MDM2, RB1, CDKN2A, CD44
17MP:00053878.9CCND1, MDM2, RB1, TYMP, CDKN2A, CD44
18MP:00053848.8HSPA4, CCND1, MDM2, PISD, RB1, TYMP
19MP:00107688.7HSPA4, CCND1, MDM2, PISD, RB1, CDKN2A
20MP:00053788.6CDKN2A, RB1, PISD, MDM2, CCND1, CD44

Publications for Verrucous Carcinoma

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Sources:
50PubMed
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Articles related to Verrucous Carcinoma:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Periorbital Reconstruction Following Removal of a Large Verrucous Carcinoma. (23590212)
2013
2
Verrucous carcinoma on the helix of pinna. (23641380)
2013
3
Verrucous carcinoma: a rare tumor of the eyelid. (20562662)
2011
4
Human papillomavirus types 1, 16 and 18 detected in a lesion of verrucous carcinoma of the cheek. (21574982)
2011
5
Intraarterial chemotherapy: a valid option in the treatment of verrucous carcinoma? (20037787)
2010
6
Nodule in the floor of the mouth. Verrucous carcinoma. (20478808)
2010
7
Locally advanced anourological verrucous carcinoma: a multidisciplinary approach. (19288239)
2009
8
Management of verrucous carcinoma of the hand: a case report. (20064184)
2009
9
Plantar verrucous carcinoma: an unusual case of bone invasion and osteomyelitis. (19935131)
2009
10
Surgical outcome in patients with oral verrucous carcinoma: long-term follow-up in an endemic betel quid chewing area. (20029242)
2009
11
Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression. (18580072)
2008
12
Verrucous carcinoma of the scalp. (17141366)
2007
13
Lip verrucous carcinoma in a pregnant woman successfully treated with carbon dioxide laser surgery. (17627786)
2007
14
Verrucous carcinoma presenting as giant plantar horns. (17430391)
2007
15
Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features. (17032398)
2006
16
Treatment of verrucous carcinoma with topical imiquimod. (16631950)
2006
17
Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. (15229749)
2004
18
Plantar verrucous carcinoma continues to be mistaken for verruca vulgaris. (15108936)
2004
19
Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma. (12576421)
2003
20
Primary intraosseous verrucous carcinoma developing from a maxillary odontogenic cyst: case report. (11989603)
2001
21
Verrucous carcinoma of the foot: a review and report of two cases. (11924683)
2001
22
Invasive verrucous carcinoma: a temporal bone histopathology report. (10733148)
2000
23
A case report: verrucous carcinoma of the endometrium--the difficulty of diagnosis, and a review of the literature. (10932980)
2000
24
Subcutaneous ("inverted") verrucous carcinoma with bone invasion. (9056660)
1997
25
Case 8. Verrucous carcinoma. (10332388)
1995
26
Verrucous carcinoma of the genital tract: is it a distinct entity? (8472225)
1993
27
Keratoacanthoma or verrucous carcinoma? A case report. (8130788)
1993
28
Human papillomavirus type 1 DNA in verrucous carcinoma of the leg. (8245239)
1993
29
Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. (1586504)
1992
30
Image analysis in the discrimination of verrucous carcinoma and squamous papilloma. (1517892)
1992
31
Verrucous carcinoma of the anus containing human papillomavirus type 16 DNA detected by in situ hybridisation: a case report. (2174020)
1990
32
Verrucous carcinoma of the oral cavity. (3043642)
1988
33
Human papillomavirus type 2 DNA in oral verrucous carcinoma. (3027288)
1986
34
Verrucous carcinoma pedis (epithelioma cuniculatum). (4020667)
1985
35
Oral verrucous carcinoma. (3936796)
1985
36
Verrucous carcinoma, hyperplasia and leukoplakia of the oral mucosa: a clinico-histopathological and histometric study. (16245630)
1985
37
Giant irritated seborrheic keratosis mimicking verrucous carcinoma. (3910690)
1985
38
Verrucous carcinoma of the face. (6703740)
1984
39
Verrucous carcinoma--changing concepts in management. (6716554)
1984
40
Verrucous carcinoma of the uterine cervix: report of a case with follow-up of 6 1/2 years. (6489831)
1984
41
Giant verrucous carcinoma in a giraffe. (6703261)
1984
42
Verrucous carcinoma of the uterine cervix. Case reports. (7123410)
1982
43
Verrucous carcinoma of the penis or Buschke-LAPwenstein tumour. (7461007)
1981
44
Verrucous lesions of the female genitalia. II. Verrucous carcinoma. (7386524)
1980
45
Verrucous carcinoma of the oral cavity: management by radiotherapy and surgery. (7363153)
1980
46
Plantar verrucous carcinoma. Literature review and treatment by the Mohs' chemosurgery technique. (7396544)
1980
47
Verrucous carcinoma arising from an artificial vagina. (876534)
1977
48
Verrucous carcinoma of the oral cavity treated with bleomycin. (62332)
1976
49
Ineffectiveness of bleomycin in verrucous carcinoma of the vulva. (95665)
1975
50
Verrucous carcinoma of the larynx. (1139425)
1975

Genetic Variations for Verrucous Carcinoma

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Expression for genes affiliated with Verrucous Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

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Sources:
51QIAGEN, 53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB3
210.2CDKN1A, MDM2
310.1MDM2, CDKN1A, ERBB3
4
Hide members
10.0CDKN1A, MDM2, CCND1
5
Transcription Androgen Receptor nuclear signaling
Hide members
10.0CCND1, MDM2, CDKN1A
610.0CCND1, MDM2, CDKN1A
710.0MDM2, CDKN2A, CDKN1A
810.0MDM2, CDH1, ERBB3
910.0MDM2, RB1, CDKN1A
1010.0MDM2, RB1, CDKN2A
1110.0NOS2, RB1, CCND1
129.9CCND1, RB1, TGFA
13
Cell adhesion ECM remodeling
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9.9CD44, CDH1, MSN
14
Hide members
9.9CDKN1A, RB1, MDM2, CCND1
15
Hide members
9.9CCND1, MDM2, RB1, CDKN1A
169.9CDKN1A, RB1, MDM2, CCND1
17
Transcription P53 signaling pathway
Hide members
9.9MDM2, RB1, CDKN2A, CDKN1A
18
Hide members
9.9CCND1, MDM2, CDH1, CDKN1A
199.9CCND1, RB1, CDKN2A, CDKN1A
20
Hide members
9.9CCND1, RB1, CDKN2A, CDKN1A
21
Cell cycle Cell cycle (generic schema)
Hide members
9.9CCND1, RB1, CDKN2A, CDKN1A
229.9CCND1, MDM2, RB1, CDH1
239.9CDKN1A, CD44, RB1, MDM2
249.8CCND1, RB1, CD44, CDKN1A
25
Hide members
9.8NOS2, CDKN1A, RB1, CCND1
269.8TGFA, CDKN1A, RB1, MDM2
279.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
289.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
29
Hide members
9.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
30
Hide members
9.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
31
Hide members
9.7CDKN1A, CDKN2A, RB1, MDM2, CCND1
32
Hide members
9.7CCND1, MDM2, CDKN2A, CD44, CDKN1A
33
Hide members
9.7MDM2, RB1, CDKN2A, CDH1, CDKN1A
349.7MDM2, RB1, CDKN2A, CD44, CDKN1A
35
Hide members
9.7CCND1, MDM2, CDKN1A, ERBB3, TGFA
36
Hide members
9.7TGFA, ERBB3, CDKN1A, MDM2, CCND1
379.6CCND1, MDM2, CDKN2A, CD44, CDKN1A, ERBB3
38
Hide members
9.5TGFA, MDM2, RB1, TYMP, CDKN1A, ERBB3
399.5CCND1, MDM2, CD44, CDKN1A, MSN, ERBB3
40
Hide members
9.5CCND1, MDM2, RB1, CDKN2A, CDKN1A, TGFA
41
Hide members
9.5MDM2, RB1, CDKN2A, CD44, ERBB3, TGFA
42
Hide members
9.5HSPA4, CCND1, MDM2, RB1, CDH1, CDKN1A
439.1CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A
44
Hide members
9.0CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A

Compounds for genes affiliated with Verrucous Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7MSN
2resveratrol44 59 11 2413.7TGFA
3cycloheximide4410.6MSN, TYMP
4vincristine44 49 1112.4CCND1, RB1, TYMP
5serine4410.4CDH1, CCND1, CD44
6depsipeptide4410.3CCND1, CDKN2A, CDH1
7estradiol44 11 2412.2ERBB3, RB1, MDM2
8olomoucine44 1111.1CDKN1A, CCND1, RB1, CDKN2A
9crcs4410.1CDH1, CCND1, RB1, TYMP, CDKN2A
10roscovitine4410.0CDKN2A, CDKN1A, RB1, MDM2, CCND1
11erlotinib44 49 1112.0CDH1, ERBB3, TGFA, TYMP, CCND1
12p000014410.0CDH1, CD44, CDKN2A, TYMP, MDM2, CCND1
13irinotecan44 49 1112.0CDH1, CDKN2A, TYMP, CDKN1A, MDM2
14p002449.9MDM2, RB1, CD44, CDH1, ERBB3, TYMP
15gefitinib44 49 1111.9CCND1, TGFA, ERBB3, CDKN1A, CDH1, MDM2
16flavopiridol44 1110.9CCND1, CDKN2A, CDKN1A, MDM2, RB1, HSPA4
17thymidylate449.8CDKN1A, CCND1, MDM2, RB1, TYMP, CDKN2A
18adpribose449.8MDM2, HSPA4, CDKN1A, CCND1, RB1
19formaldehyde44 2410.8CCND1, TGFA, RB1, CDH1, CD44, TYMP
20gemcitabine44 49 1111.7TYMP, ERBB3, CDKN1A, CCND1, HSPA4
21geldanamycin44 49 59 1112.7CDKN1A, MDM2, CCND1, HSPA4, CDH1
22dexamethasone44 49 28 1112.7SPRR1B, CDH1, CDKN2A, RB1, HSPA4, MDM2
23curcumin449.7NOS2, CDKN1A, CCND1, CDH1, MDM2, HSPA4
24methotrexate44 49 1111.7CDKN2A, CDH1, TYMP, CCND1, RB1, MDM2
25calcitriol44 59 11 2412.7RB1, KRT10, CD44, TGFA, CDH1, CDKN1A
26mg 13244 5910.7CDH1, CCND1, CDKN1A, HSPA4, MDM2, NOS2
27bromodeoxyuridine449.7HSPA4, CD44, RB1, CDKN1A, KRT10, TGFA
28rapamycin449.6TGFA, CDKN1A, MDM2, RB1, CDH1, ERBB3
29etoposide44 49 59 1112.6MDM2, RB1, CD44, CDH1, TGFA
30cisplatin44 49 59 1112.6MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
31adriamycin449.6CDH1, CDKN1A, CD44, CDKN2A, RB1, MDM2
32steroid449.5CDKN2A, CCND1, RB1, CD44, KRT10, ERBB3
335fluorouracil449.5HSPA4, TGFA, CDKN1A, CDH1, TYMP, RB1
34pd 98,059449.5CDH1, MDM2, RB1, TGFA, CCND1, HSPA4
35tamoxifen44 49 28 1112.5CDH1, TGFA, ERBB3, CDKN1A, CD44, TYMP
36paclitaxel44 49 1111.5CDKN2A, CDH1, CD44, RB1, CDKN1A, TYMP
37paraffin449.5HSPA4, CDH1, CDKN1A, ERBB3, TGFA, CD44
38p003449.4MDM2, CDH1, CD44, TYMP, RB1
39agar449.4TGFA, HSPA4, CCND1, CDKN1A, CDH1, CDKN2A
40matrigel449.4CDH1, TGFA, CD44, CCND1, TYMP, RB1
41actinomycin d449.3RB1, TYMP, MDM2, HSPA4, TGFA, NOS2
42testosterone44 59 11 2412.3RB1, CD44, CDKN2A, ERBB3, MDM2, CCND1
43genistein44 28 59 2 11 2414.2HSPA4, CCND1, MDM2, RB1, CDKN2A, CDKN1A
44oligonucleotide449.1TGFA, ERBB3, MSN, CCND1, MDM2, CDKN1A
45ly294002449.1CDH1, HSPA4, CCND1, MDM2, RB1, TYMP
46retinoic acid44 2410.0CDKN1A, CDH1, CD44, CDKN2A, CCND1, HSPA4
47progesterone44 59 28 11 2413.0CCND1, CDKN2A, CD44, CDH1, CDKN1A, MDM2
48doxorubicin44 49 1110.9NOS2, CDKN1A, CDH1, ERBB3, TGFA, CD44
49vegf448.9CDKN1A, CDH1, NOS2, ERBB3, HSPA4, CD44
50tyrosine448.9MSN, TGFA, TYMP, ERBB3, RB1, CD44

GO Terms for genes affiliated with Verrucous Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.2CDKN1A, CCND1
2basolateral plasma membraneGO:0163239.3TGFA, ERBB3, MSN, CDH1, CD44

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to magnesium ionGO:03202610.2MDM2, CCND1
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.2CD44, MDM2
3keratinocyte differentiationGO:03021610.1SPRR1B, SPRR3, KRT10
4wound healingGO:04206010.0ERBB3, SPRR3, TGFA
5epidermal growth factor receptor signaling pathwayGO:00717310.0MDM2, CDKN1A, ERBB3, TGFA
6Ras protein signal transductionGO:0072659.9RB1, CDKN2A, CDKN1A
7response to iron ionGO:0100399.9MDM2, CCND1
8response to drugGO:0424939.8TGFA, CDKN1A, CDH1, MDM2, CCND1

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1A, CDKN2A

Products for genes affiliated with Verrucous Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Verrucous Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet