MCID: VRR004
MIFTS: 51

Verrucous Carcinoma malady

Cancer diseases category

Summaries for Verrucous Carcinoma

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to papilloma and epidermolysis bullosa simplex. An important gene associated with Verrucous Carcinoma is MIR125A (microRNA 125a), and among its related pathways are Glucocorticoid receptor regulatory network and ErbB signaling pathway. The compounds dutp and p00001 have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and bone, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Wikipedia:66 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

verrucous carcinoma 9 11 63
verrucous squamous cell carcinoma 9
verrucous squamous carcinoma 9
verrucous carcinoma nos 9
condylomatous carcinoma 63
carcinoma verrucous 46
warty carcinoma 9


External Ids:

Disease Ontology9 DOID:3737
NCIt41 C3781
MeSH36 D018289

Related Diseases for Verrucous Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Symptoms for Verrucous Carcinoma

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Drugs & Therapeutics for Verrucous Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Verrucous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Search CenterWatch for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

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Anatomical Context for Verrucous Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Verrucous Carcinoma:

34
Cervix, Skin, Bone, T cells, Tongue, Lymph node, Colon, Breast

Animal Models for Verrucous Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Verrucous Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MDM2, KRT10, ERBB3
2MP:00053718.6KRT10, KRT5, MDM2
3MP:00107718.0MDM2, KRT5, KRT10, ERBB3

Publications for Verrucous Carcinoma

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Sources:
53PubMed
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Articles related to Verrucous Carcinoma:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
2
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
3
Stereology study of oral verrucous carcinoma. (22740216)
2012
4
Penile verrucous carcinoma arising in HPV-negative condylomatous papules. (21524989)
2011
5
Carcinoma cunniculatum on the shoulder: an atypical localisation of a verrucous carcinoma. (18289952)
2009
6
Verrucous carcinoma of the foot: a case report. (18725683)
2008
7
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
8
Cytology of uterine cervical verrucous carcinoma. (18936012)
2008
9
Oral and maxillofacial pathology case of the month. Verrucous carcinoma. (18717430)
2008
10
Verrucous carcinoma (Buschke-Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case. (17609975)
2008
11
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
12
Verrucous carcinoma of the cervix: detection of carcinogenetic human papillomavirus types and their role during follow-up. (18214065)
2007
13
Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation. (17197212)
2007
14
Verrucous carcinoma of the scalp. (17141366)
2007
15
Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features. (17032398)
2006
16
Verrucous carcinoma of the vulva in Turner syndrome. (14751191)
2004
17
Cytomorphology of verrucous carcinoma of the cervix. A case report. (14674078)
2003
18
Eyelid verrucous carcinoma. (12474928)
2002
19
Verrucous carcinoma of the renal pelvis. (11445495)
2001
20
Verrucous carcinoma of the uterine cervix. (11076434)
2000
21
Oral verrucous carcinoma. (10102583)
1999
22
Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. (10226946)
1999
23
Plantar verrucous carcinoma following transmetatarsal amputation and renal transplantation. (9600438)
1998
24
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
25
Verrucous carcinoma or epithelioma cuniculatum plantare. (9066754)
1997
26
Verrucous carcinoma of the vulva. (9141857)
1996
27
Clinical pathology case conference. Verrucous carcinoma. (9552636)
1996
28
Verrucous carcinoma of the larynx. (7816455)
1995
29
Verrucous carcinoma of the lip originating on the vermilion border. (8002160)
1994
30
Demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. (8391880)
1993
31
Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction. (17431983)
1993
32
Verrucous carcinoma of the oesophagus and achalasia. (8439656)
1993
33
Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. (1586504)
1992
34
Verrucous carcinoma (Buschke-Lowenstein tumor). (1659557)
1991
35
Management of verrucous carcinoma of the larynx. (2070533)
1991
36
Penile verrucous carcinoma. (2396837)
1990
37
The therapy of verrucous carcinoma of the vulva. Observations on three cases. (2776786)
1989
38
Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. (2757559)
1989
39
A clinico-pathologic presentation. Verrucous carcinoma. (3473171)
1987
40
Verrucous carcinoma of the maxilla in a thirteen-year-old male. (3937104)
1985
41
Verrucous carcinoma of the uterine cervix. A case report. (6578652)
1983
42
Verrucous carcinoma of the penis (Buschke-Lowenstein tumour): a clinico-pathological study. (6883049)
1983
43
Verrucous carcinoma of the cervix uteri: report of a case. (6942625)
1981
44
Management of verrucous carcinoma on a foot by a combination of chemosurgery and plastic repair: report of a case. (7391328)
1980
45
Verrucous lesions of the female genitalia. II. Verrucous carcinoma. (7386524)
1980
46
Verrucous carcinoma of the oral cavity: management by radiotherapy and surgery. (7363153)
1980
47
Verrucous carcinoma of the cervix and endometrium. (7439016)
1980
48
Verrucous carcinoma of the vagina. (635607)
1978
49
Hemoptysis and supraglottic verrucous carcinoma. (891429)
1977
50
Ineffectiveness of bleomycin in verrucous carcinoma of the vulva. (95665)
1975

Variations for Verrucous Carcinoma

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Expression for genes affiliated with Verrucous Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB, 62Tocris Bioscience, 55R&D Systems, 58SinoBiological
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Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, KRT5
2
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.1MDM2, ERBB3
3
Show member pathways
9.1MDM2, ERBB3
49.1ERBB3, MDM2
59.1MDM2, ERBB3
68.7MDM2, ERBB3, MIR125A
7
Show member pathways
Signaling Pathways in Glioblastoma39
8.6MDM2, ERBB3, TYMP

Compounds for genes affiliated with Verrucous Carcinoma

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dutp469.9MDM2, KRT10
2p00001469.8TYMP, MDM2
3ifosfamide46 1210.8MDM2, TYMP
4calcipotriol46 62 30 1212.8KRT5, KRT10
5vinblastine46 52 1211.8TYMP, MDM2
6irinotecan46 52 1211.7TYMP, MDM2
7mitomycin c469.7TYMP, MDM2
8p003469.7MDM2, TYMP
9benzo(a)pyrene469.7MDM2, KRT5
10lead469.6TYMP, MDM2
11nucleoside469.6MDM2, TYMP
12thymidylate469.5TYMP, MDM2
13vincristine46 52 1211.5MDM2, TYMP
14erlotinib46 52 1211.5ERBB3, TYMP
15trastuzumab46 52 1211.5MDM2, ERBB3
16gefitinib46 52 1211.4MDM2, ERBB3
17cyclophosphamide46 52 1211.4MDM2, TYMP
18gemcitabine46 52 1211.4ERBB3, TYMP
19glyceraldehyde 3-phosphate469.4MDM2, KRT10, TYMP
20proline469.2KRT10, KRT5, MDM2
21docetaxel46 52 62 1212.1MDM2, TYMP
22p002469.0TYMP, ERBB3, MDM2
23arginine469.0MDM2, KRT5, KRT10
24ly294002469.0TYMP, ERBB3, MDM2
25wortmannin469.0MDM2, ERBB3, TYMP
26doxorubicin46 52 1211.0MDM2, ERBB3, TYMP
27estradiol46 25 1211.0TYMP, ERBB3, MDM2
28steroid469.0MDM2, KRT10, ERBB3
29fatty acid468.9ERBB3, KRT10, KRT5
30genistein46 30 62 3 25 1213.9MDM2, KRT5, ERBB3
31vegf468.8MDM2, ERBB3, TYMP
32testosterone46 62 25 1211.8MDM2, KRT5, ERBB3
33threonine468.5ERBB3, KRT10, KRT5, MDM2
34alanine468.4ERBB3, KRT5, MDM2
35calcium46 52 25 1211.1MDM2, KRT5, KRT10, ERBB3
36paraffin468.0MDM2, KRT5, KRT10, ERBB3, TYMP
37progesterone46 30 62 25 1212.0TYMP, ERBB3, KRT10, KRT5, MDM2
38estrogen468.0MDM2, KRT5, KRT10, ERBB3, TYMP
39serine467.9MDM2, KRT5, KRT10, ERBB3, TYMP
40tyrosine467.9TYMP, ERBB3, KRT10, KRT5, MDM2

GO Terms for genes affiliated with Verrucous Carcinoma

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17Gene Ontology
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Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT5, KRT10
2keratin filamentGO:0450959.1KRT5, KRT10

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:0085439.1MDM2, ERBB3
2phosphatidylinositol-mediated signalingGO:0480158.8MDM2, ERBB3

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.3MDM2, KRT5

Products for genes affiliated with Verrucous Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Verrucous Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet