MCID: VRR004
MIFTS: 51

Verrucous Carcinoma malady

Cancer diseases category
Download this MalaCard

Summaries for Verrucous Carcinoma

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to papilloma and epidermolysis bullosa simplex. An important gene associated with Verrucous Carcinoma is MIR125A (microRNA 125a), and among its related pathways are Glucocorticoid receptor regulatory network and ErbB signaling pathway. The compounds dutp and p00001 have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and bone, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Wikipedia:65 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

verrucous carcinoma 8 10 62
verrucous squamous cell carcinoma 8
verrucous squamous carcinoma 8
verrucous carcinoma nos 8
condylomatous carcinoma 62
carcinoma verrucous 45
warty carcinoma 8


External Ids:

Disease Ontology8 DOID:3737
NCIt40 C3781
MeSH35 D018289

Related Diseases for Verrucous Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Symptoms for Verrucous Carcinoma

About this section

Drugs & Therapeutics for Verrucous Carcinoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

About this section

Anatomical Context for Verrucous Carcinoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Verrucous Carcinoma:

33
Cervix, Skin, Bone, T cells, Tongue, Lymph node, Colon, Breast

Animal Models for Verrucous Carcinoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Verrucous Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MDM2, KRT10, ERBB3
2MP:00053718.6KRT10, KRT5, MDM2
3MP:00107718.0MDM2, KRT5, KRT10, ERBB3

Publications for Verrucous Carcinoma

About this section
Sources:
52PubMed
See all sources

Articles related to Verrucous Carcinoma:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
2
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
3
Stereology study of oral verrucous carcinoma. (22740216)
2012
4
Penile verrucous carcinoma arising in HPV-negative condylomatous papules. (21524989)
2011
5
Carcinoma cunniculatum on the shoulder: an atypical localisation of a verrucous carcinoma. (18289952)
2009
6
Verrucous carcinoma of the foot: a case report. (18725683)
2008
7
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
8
Cytology of uterine cervical verrucous carcinoma. (18936012)
2008
9
Oral and maxillofacial pathology case of the month. Verrucous carcinoma. (18717430)
2008
10
Verrucous carcinoma (Buschke-Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case. (17609975)
2008
11
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
12
Verrucous carcinoma of the cervix: detection of carcinogenetic human papillomavirus types and their role during follow-up. (18214065)
2007
13
Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation. (17197212)
2007
14
Verrucous carcinoma of the scalp. (17141366)
2007
15
Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features. (17032398)
2006
16
Verrucous carcinoma of the vulva in Turner syndrome. (14751191)
2004
17
Cytomorphology of verrucous carcinoma of the cervix. A case report. (14674078)
2003
18
Eyelid verrucous carcinoma. (12474928)
2002
19
Verrucous carcinoma of the renal pelvis. (11445495)
2001
20
Verrucous carcinoma of the uterine cervix. (11076434)
2000
21
Oral verrucous carcinoma. (10102583)
1999
22
Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. (10226946)
1999
23
Plantar verrucous carcinoma following transmetatarsal amputation and renal transplantation. (9600438)
1998
24
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
25
Verrucous carcinoma or epithelioma cuniculatum plantare. (9066754)
1997
26
Verrucous carcinoma of the vulva. (9141857)
1996
27
Clinical pathology case conference. Verrucous carcinoma. (9552636)
1996
28
Verrucous carcinoma of the larynx. (7816455)
1995
29
Verrucous carcinoma of the lip originating on the vermilion border. (8002160)
1994
30
Demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. (8391880)
1993
31
Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction. (17431983)
1993
32
Verrucous carcinoma of the oesophagus and achalasia. (8439656)
1993
33
Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. (1586504)
1992
34
Verrucous carcinoma (Buschke-Lowenstein tumor). (1659557)
1991
35
Management of verrucous carcinoma of the larynx. (2070533)
1991
36
Penile verrucous carcinoma. (2396837)
1990
37
The therapy of verrucous carcinoma of the vulva. Observations on three cases. (2776786)
1989
38
Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. (2757559)
1989
39
A clinico-pathologic presentation. Verrucous carcinoma. (3473171)
1987
40
Verrucous carcinoma of the maxilla in a thirteen-year-old male. (3937104)
1985
41
Verrucous carcinoma of the uterine cervix. A case report. (6578652)
1983
42
Verrucous carcinoma of the penis (Buschke-Lowenstein tumour): a clinico-pathological study. (6883049)
1983
43
Verrucous carcinoma of the cervix uteri: report of a case. (6942625)
1981
44
Management of verrucous carcinoma on a foot by a combination of chemosurgery and plastic repair: report of a case. (7391328)
1980
45
Verrucous lesions of the female genitalia. II. Verrucous carcinoma. (7386524)
1980
46
Verrucous carcinoma of the oral cavity: management by radiotherapy and surgery. (7363153)
1980
47
Verrucous carcinoma of the cervix and endometrium. (7439016)
1980
48
Verrucous carcinoma of the vagina. (635607)
1978
49
Hemoptysis and supraglottic verrucous carcinoma. (891429)
1977
50
Ineffectiveness of bleomycin in verrucous carcinoma of the vulva. (95665)
1975

Variations for Verrucous Carcinoma

About this section

Expression for genes affiliated with Verrucous Carcinoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 61Tocris Bioscience, 54R&D Systems, 57SinoBiological
See all sources

Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, KRT5
2
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1MDM2, ERBB3
3
Show member pathways
9.1MDM2, ERBB3
49.1ERBB3, MDM2
59.1MDM2, ERBB3
68.7MDM2, ERBB3, MIR125A
7
Show member pathways
Signaling Pathways in Glioblastoma38
8.6MDM2, ERBB3, TYMP

Compounds for genes affiliated with Verrucous Carcinoma

About this section
Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB, 3BitterDB
See all sources

Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dutp459.9MDM2, KRT10
2p00001459.8TYMP, MDM2
3ifosfamide45 1110.8MDM2, TYMP
4calcipotriol45 61 29 1112.8KRT5, KRT10
5vinblastine45 51 1111.8TYMP, MDM2
6irinotecan45 51 1111.7TYMP, MDM2
7mitomycin c459.7TYMP, MDM2
8p003459.7MDM2, TYMP
9benzo(a)pyrene459.7MDM2, KRT5
10lead459.6TYMP, MDM2
11nucleoside459.6MDM2, TYMP
12thymidylate459.5TYMP, MDM2
13vincristine45 51 1111.5MDM2, TYMP
14erlotinib45 51 1111.5ERBB3, TYMP
15trastuzumab45 51 1111.5MDM2, ERBB3
16gefitinib45 51 1111.4MDM2, ERBB3
17cyclophosphamide45 51 1111.4MDM2, TYMP
18gemcitabine45 51 1111.4ERBB3, TYMP
19glyceraldehyde 3-phosphate459.4MDM2, KRT10, TYMP
20proline459.2KRT10, KRT5, MDM2
21docetaxel45 51 61 1112.1MDM2, TYMP
22p002459.0TYMP, ERBB3, MDM2
23arginine459.0MDM2, KRT5, KRT10
24ly294002459.0TYMP, ERBB3, MDM2
25wortmannin459.0MDM2, ERBB3, TYMP
26doxorubicin45 51 1111.0MDM2, ERBB3, TYMP
27estradiol45 24 1111.0TYMP, ERBB3, MDM2
28steroid459.0MDM2, KRT10, ERBB3
29fatty acid458.9ERBB3, KRT10, KRT5
30genistein45 29 61 3 24 1113.9MDM2, KRT5, ERBB3
31vegf458.8MDM2, ERBB3, TYMP
32testosterone45 61 24 1111.8MDM2, KRT5, ERBB3
33threonine458.5ERBB3, KRT10, KRT5, MDM2
34alanine458.4ERBB3, KRT5, MDM2
35calcium45 51 24 1111.1MDM2, KRT5, KRT10, ERBB3
36paraffin458.0MDM2, KRT5, KRT10, ERBB3, TYMP
37progesterone45 29 61 24 1112.0TYMP, ERBB3, KRT10, KRT5, MDM2
38estrogen458.0MDM2, KRT5, KRT10, ERBB3, TYMP
39serine457.9MDM2, KRT5, KRT10, ERBB3, TYMP
40tyrosine457.9TYMP, ERBB3, KRT10, KRT5, MDM2

GO Terms for genes affiliated with Verrucous Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT5, KRT10
2keratin filamentGO:0450959.1KRT5, KRT10

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:0085439.1MDM2, ERBB3
2phosphatidylinositol-mediated signalingGO:0480158.8MDM2, ERBB3

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.3MDM2, KRT5

Products for genes affiliated with Verrucous Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Verrucous Carcinoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet