MCID: VRR004
MIFTS: 50

Verrucous Carcinoma malady

Cancer diseases category

Summaries for Verrucous Carcinoma

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Disease Ontology:10 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards based summary: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to papilloma and adenocarcinoma. An important gene associated with Verrucous Carcinoma is MIR125A (microRNA 125a), and among its related pathways are Glucocorticoid receptor regulatory network and ErbB signaling pathway. The compounds dutp and p00001 have been mentioned in the context of this disorder. Affiliated tissues include cervix, bone and skin, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Wikipedia:65 Verrucous carcinoma(VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often... more...

Aliases & Classifications for Verrucous Carcinoma

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Verrucous Carcinoma, Aliases & Descriptions:

Name: Verrucous Carcinoma 10 12 62
Verrucous Squamous Cell Carcinoma 10 62
Verrucous Squamous Carcinoma 10 62
Verrucous Carcinoma Nos 10
 
Condylomatous Carcinoma 62
Carcinoma Verrucous 45
Warty Carcinoma 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:3737
MeSH35 D018289
NCIt40 C3781

Related Diseases for Verrucous Carcinoma

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Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Symptoms for Verrucous Carcinoma

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Drugs & Therapeutics for Verrucous Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

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Anatomical Context for Verrucous Carcinoma

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MalaCards organs/tissues related to Verrucous Carcinoma:

33
Cervix, Bone, Skin, T cells, Tongue, Lymph node, Smooth muscle, Colon, Breast, Testes, Neutrophil

Animal Models for Verrucous Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Verrucous Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7MDM2, KRT10, ERBB3
2MP:00053718.6KRT10, KRT5, MDM2
3MP:00107718.0MDM2, KRT5, KRT10, ERBB3

Publications for Verrucous Carcinoma

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Articles related to Verrucous Carcinoma:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Diagnosis and treatment of penile verrucous carcinoma. (25789024)
2015
2
An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma. (25214794)
2014
3
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
4
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
5
Stereology study of oral verrucous carcinoma. (22740216)
2012
6
Penile verrucous carcinoma arising in HPV-negative condylomatous papules. (21524989)
2011
7
Carcinoma cunniculatum on the shoulder: an atypical localisation of a verrucous carcinoma. (18289952)
2009
8
Verrucous carcinoma of the foot: a case report. (18725683)
2008
9
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
10
Cytology of uterine cervical verrucous carcinoma. (18936012)
2008
11
Oral and maxillofacial pathology case of the month. Verrucous carcinoma. (18717430)
2008
12
Verrucous carcinoma (Buschke-Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case. (17609975)
2008
13
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
14
Verrucous carcinoma of the cervix: detection of carcinogenetic human papillomavirus types and their role during follow-up. (18214065)
2007
15
Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation. (17197212)
2007
16
Verrucous carcinoma of the scalp. (17141366)
2007
17
Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features. (17032398)
2006
18
Verrucous carcinoma of the vulva in Turner syndrome. (14751191)
2004
19
Cytomorphology of verrucous carcinoma of the cervix. A case report. (14674078)
2003
20
Eyelid verrucous carcinoma. (12474928)
2002
21
Verrucous carcinoma of the renal pelvis. (11445495)
2001
22
Oral verrucous carcinoma. (10102583)
1999
23
Plantar verrucous carcinoma following transmetatarsal amputation and renal transplantation. (9600438)
1998
24
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
25
Verrucous carcinoma or epithelioma cuniculatum plantare. (9066754)
1997
26
Verrucous carcinoma of the vulva. (9141857)
1996
27
Clinical pathology case conference. Verrucous carcinoma. (9552636)
1996
28
Verrucous carcinoma of the larynx. (7816455)
1995
29
Verrucous carcinoma of the lip originating on the vermilion border. (8002160)
1994
30
Demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. (8391880)
1993
31
Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction. (17431983)
1993
32
Verrucous carcinoma of the oesophagus and achalasia. (8439656)
1993
33
Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. (1586504)
1992
34
Verrucous carcinoma (Buschke-Lowenstein tumor). (1659557)
1991
35
Management of verrucous carcinoma of the larynx. (2070533)
1991
36
Penile verrucous carcinoma. (2396837)
1990
37
The therapy of verrucous carcinoma of the vulva. Observations on three cases. (2776786)
1989
38
Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. (2757559)
1989
39
A clinico-pathologic presentation. Verrucous carcinoma. (3473171)
1987
40
Verrucous carcinoma of the maxilla in a thirteen-year-old male. (3937104)
1985
41
Verrucous carcinoma of the uterine cervix. A case report. (6578652)
1983
42
Verrucous carcinoma of the penis (Buschke-Lowenstein tumour): a clinico-pathological study. (6883049)
1983
43
Verrucous carcinoma of the cervix uteri: report of a case. (6942625)
1981
44
Management of verrucous carcinoma on a foot by a combination of chemosurgery and plastic repair: report of a case. (7391328)
1980
45
Verrucous lesions of the female genitalia. II. Verrucous carcinoma. (7386524)
1980
46
Verrucous carcinoma of the oral cavity: management by radiotherapy and surgery. (7363153)
1980
47
Verrucous carcinoma of the cervix and endometrium. (7439016)
1980
48
Verrucous carcinoma of the vagina. (635607)
1978
49
Hemoptysis and supraglottic verrucous carcinoma. (891429)
1977
50
Ineffectiveness of bleomycin in verrucous carcinoma of the vulva. (95665)
1975

Variations for Verrucous Carcinoma

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Expression for genes affiliated with Verrucous Carcinoma

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Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

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Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, KRT5
2
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1MDM2, ERBB3
3
Show member pathways
9.1MDM2, ERBB3
49.1ERBB3, MDM2
59.1ERBB3, MDM2
68.7MIR125A, ERBB3, MDM2
7
Show member pathways
Signaling Pathways in Glioblastoma38
8.6MDM2, ERBB3, TYMP

Compounds for genes affiliated with Verrucous Carcinoma

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Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dutp459.9MDM2, KRT10
2p00001459.8TYMP, MDM2
3ifosfamide45 1310.8MDM2, TYMP
4calcipotriol45 61 30 1312.8KRT5, KRT10
5vinblastine45 51 1311.8TYMP, MDM2
6irinotecan45 51 1311.7TYMP, MDM2
7mitomycin c459.7TYMP, MDM2
8p003459.7MDM2, TYMP
9benzo(a)pyrene459.7MDM2, KRT5
10lead459.6TYMP, MDM2
11nucleoside459.6MDM2, TYMP
12thymidylate459.5TYMP, MDM2
13vincristine45 51 1311.5MDM2, TYMP
14erlotinib45 51 1311.5ERBB3, TYMP
15trastuzumab45 51 1311.5MDM2, ERBB3
16gefitinib45 51 1311.4MDM2, ERBB3
17cyclophosphamide45 51 1311.4MDM2, TYMP
18gemcitabine45 51 1311.4ERBB3, TYMP
19glyceraldehyde 3-phosphate459.4MDM2, KRT10, TYMP
20proline459.2KRT10, KRT5, MDM2
21docetaxel45 51 61 1312.1MDM2, TYMP
22p002459.0TYMP, ERBB3, MDM2
23arginine459.0MDM2, KRT5, KRT10
24ly294002459.0TYMP, ERBB3, MDM2
25wortmannin459.0MDM2, ERBB3, TYMP
26doxorubicin45 51 1311.0MDM2, ERBB3, TYMP
27estradiol45 26 1311.0TYMP, ERBB3, MDM2
28steroid459.0MDM2, KRT10, ERBB3
29fatty acid458.9ERBB3, KRT10, KRT5
30genistein45 30 61 3 26 1313.9MDM2, KRT5, ERBB3
31vegf458.8MDM2, ERBB3, TYMP
32testosterone45 61 26 1311.8MDM2, KRT5, ERBB3
33threonine458.5ERBB3, KRT10, KRT5, MDM2
34alanine458.4ERBB3, KRT5, MDM2
35calcium45 51 26 1311.1MDM2, KRT5, KRT10, ERBB3
36paraffin458.0MDM2, KRT5, KRT10, ERBB3, TYMP
37progesterone45 30 61 26 1312.0TYMP, ERBB3, KRT10, KRT5, MDM2
38estrogen458.0MDM2, KRT5, KRT10, ERBB3, TYMP
39serine457.9MDM2, KRT5, KRT10, ERBB3, TYMP
40tyrosine457.9TYMP, ERBB3, KRT10, KRT5, MDM2

GO Terms for genes affiliated with Verrucous Carcinoma

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Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.4KRT5, KRT10
2keratin filamentGO:00450959.1KRT5, KRT10

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathwayGO:00085439.1MDM2, ERBB3
2phosphatidylinositol-mediated signalingGO:00480158.8MDM2, ERBB3

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.3MDM2, KRT5

Products for genes affiliated with Verrucous Carcinoma

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Sources for Verrucous Carcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet