MCID: VRR004
MIFTS: 56

Verrucous Carcinoma malady

Cancer category

Summaries for Verrucous Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

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Disease Ontology:8 A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.

MalaCards: Verrucous Carcinoma, also known as verrucous squamous cell carcinoma, is related to squamous cell carcinoma and bladder carcinoma. An important gene associated with Verrucous Carcinoma is KRT10 (keratin 10), and among its related pathways are GPCR Pathway and AKT phosphorylates targets in the cytosol. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lymph node, and related mouse phenotypes are homeostasis/metabolism and embryogenesis.

Wikipedia:64 Verrucous carcinoma is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen... more...

Aliases & Classifications for Verrucous Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

verrucous carcinoma 8 10 61
verrucous squamous cell carcinoma 8
verrucous squamous carcinoma 8
condylomatous carcinoma 61
verrucous carcinoma nos 8
carcinoma verrucous 45
warty carcinoma 8


External Ids:

Disease Ontology8 DOID:3737
NCIt40 C3781
MeSH35 D018289

Related Diseases for Verrucous Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Verrucous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.0CCND1, CD44, CDH1, TGFA
2bladder carcinoma30.7MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
3lichen planus30.5KRT10
4lichen sclerosus30.2CD44
5adenocarcinoma30.2CDKN2A, TYMP, RB1, MDM2, CCND1, CD44
6hepatitis c30.0TYMP, HSPA4
7nasopharynx carcinoma30.0CDKN2A, CDH1
8renal clear cell carcinoma30.0TGFA, CDH1
9oral cancer30.0HSPA4, CCND1, MDM2, RB1, CDKN2A, CDH1
10verrucous papilloma10.9
11larynx verrucous carcinoma10.8
12vulva verrucous carcinoma10.8
13esophagus verrucous carcinoma10.6
14bone carcinoma10.6
15oral squamous cell carcinoma10.6
16cervical verrucous carcinoma10.4
17bladder verrucous squamous cell carcinoma10.4
18glottis verrucous carcinoma10.4
19penis non-invasive verrucous carcinoma10.3
20subglottis verrucous carcinoma10.3
21supraglottis verrucous carcinoma10.3
22urethral verrucous carcinoma10.3
23balanitis10.3
24burn scar10.2
25squamous cell papilloma10.2
26eye carcinoma10.2
27oral submucous fibrosis10.2
28eyelid carcinoma10.2
29oral mucosa leukoplakia10.2
30skin carcinoma in situ10.2
31skin squamous cell carcinoma10.2
32vulva squamous cell carcinoma10.2
33buschke lowenstein tumor10.2
34leukoplakia10.2
35oral leukoplakia10.2
36oral lichen planus10.2
37gout10.0
38urinary schistosomiasis10.0
39ankylosis10.0
40epidermolysis bullosa simplex10.0
41common wart10.0
42achalasia10.0
43hidradenitis suppurativa10.0
44female breast carcinoma10.0
45spindle cell carcinoma10.0
46fallopian tube serous adenocarcinoma10.0
47renal pelvis squamous cell carcinoma10.0
48syringocystadenoma papilliferum10.0
49noma10.0
50oral candidiasis10.0

Graphical network of the top 20 diseases related to Verrucous Carcinoma:



Diseases related to verrucous carcinoma

Clinical Features for Verrucous Carcinoma

Drugs & Therapeutics for Verrucous Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Verrucous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Verrucous Carcinoma

Search NIH Clinical Center for Verrucous Carcinoma

Search CenterWatch for Verrucous Carcinoma

Genetic Tests for Verrucous Carcinoma

Anatomical Context for Verrucous Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Verrucous Carcinoma:

33
Skin, Tongue, Lymph node, Colon, Breast, Cervix, T cells, B cells

Animal Models for Verrucous Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Verrucous Carcinoma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2ACOT13, PISD
2MP:000538010.1ERBB3, PISD
3MP:00053919.9TGFA
4MP:00053909.9CCND1, RB1, CD44, CDKN1A, TGFA
5MP:00053799.8HSPA4, CCND1, RB1, CDKN2A, CD44, CDKN1A
6MP:00053699.7MDM2, RB1, CDKN2A, CDKN1A, ERBB3, TGFA
7MP:00053899.7CCND1, CDKN2A, CD44, CDH1, CDKN1A, TGFA
8MP:00036319.7HSPA4, TYMP, CDKN1A, NOS2, ERBB3
9MP:00053889.6CCND1, RB1, CD44, CDKN1A, ERBB3
10MP:00053829.5CCND1, MDM2, RB1, CDKN1A, KRT10, NOS2
11MP:00107719.5CCND1, MDM2, RB1, CDKN2A, CDH1, CDKN1A
12MP:00053709.5MDM2, RB1, CDKN2A, CD44, CDKN1A, NOS2
13MP:00020069.3CDKN2A, RB1, MDM2, CCND1, CD44, CDH1
14MP:00053859.1CCND1, MDM2, RB1, CD44, CDH1, CDKN1A
15MP:00053869.0HSPA4, CCND1, MDM2, RB1, CDKN2A, CD44
16MP:00053819.0TGFA, CCND1, MDM2, RB1, CDKN2A, CD44
17MP:00053878.9CCND1, MDM2, RB1, TYMP, CDKN2A, CD44
18MP:00053848.8HSPA4, CCND1, MDM2, PISD, RB1, TYMP
19MP:00107688.7HSPA4, CCND1, MDM2, PISD, RB1, CDKN2A
20MP:00053788.6CDKN2A, RB1, PISD, MDM2, CCND1, CD44

Publications for Verrucous Carcinoma

Sources:
51PubMed
See all sources

Articles related to Verrucous Carcinoma:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Verrucous carcinoma of the foot with bone invasion: a case report. (23653876)
2013
2
Bilateral fungiform papilloma with synchronous verrucous carcinoma of the nasal septum: a rare presentation and a literature review. (22182527)
2012
3
Oral verrucous carcinoma mimicking a chronic candidiasis: a case report. (22720181)
2012
4
Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene. (22639907)
2012
5
Development of squamous cell carcinoma on an inflammatory linear verrucous epidermal nevus in the genital area. (22838090)
2012
6
Verrucous carcinoma of the skin: a report on 5 Japanese cases. (21396866)
2011
7
Advanced penile verrucous carcinoma treated with intra-aortic infusion chemotherapy. (20303107)
2010
8
Verrucous carcinoma of the foot affecting the bone: utility of the computed tomography scanner. (20178704)
2010
9
Carcinoma cunniculatum on the shoulder: an atypical localisation of a verrucous carcinoma. (18289952)
2009
10
Verrucous carcinoma of the tibia arising after chronic osteomyelitis: a case report. (19263015)
2009
11
Verrucous carcinoma of the foot and enhancement assessment by MRI. (19183994)
2009
12
Primary treatment of verrucous carcinoma of the penis with fluorouracil, cis-diamino-dichloro-platinum, and radiation therapy. (19687438)
2009
13
Verrucous carcinoma of the foot: a case report. (18725683)
2008
14
Synchronous verrucous carcinoma and cutaneous T-cell lymphoma. (18489047)
2008
15
Orbital metastasis from verrucous carcinoma of the oral cavity: case report and review of the literature. (18019435)
2007
16
Sinonasal verrucous carcinoma with oral invasion. (17051874)
2006
17
Invasive squamous cell carcinoma arising from verrucous carcinoma. Recognition of verrucous carcinoma of skin as an in situ carcinoma. (16935807)
2006
18
Proliferative verrucous leukoplakia: unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. (14969824)
2004
19
Verrucous carcinoma of the axilla: case report and review. (14690468)
2004
20
Cytomorphology of verrucous carcinoma of the cervix. A case report. (14674078)
2003
21
A case report of multicentric verrucous carcinoma of the female genital tract. (12893224)
2003
22
Response to article "Plantar verrucous carcinoma: report of a case treated with Boyd amputation followed by reconstruction with a free foream flap (J Dermatol, 28,226-230,2001)". (12227493)
2002
23
Lethal cutaneous verrucous carcinoma. (12051088)
2002
24
Verrucous carcinoma arising in hidradenitis suppurativa. (11151441)
2000
25
Comparative study of invasive squamous cell carcinoma and verrucous carcinoma of the oral cavity: expression of bcl-2, p53, and Her-2/neu, and indexes of cell turnover. (9398988)
1997
26
Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma: an immunohistochemical study. (8843456)
1996
27
Verrucous carcinoma of the oesophagus and achalasia. (8439656)
1993
28
Human papillomavirus-induced verrucous carcinoma of the mouth. Case report of an aggressive tumor. (8396162)
1993
29
Case report: radiotherapy--an effective treatment for vaginal verrucous carcinoma. (8495295)
1993
30
Verrucous carcinoma of the bladder. (1638382)
1992
31
Bleomycin iontophoretic therapy for verrucous carcinoma. (1712184)
1991
32
Verrucous carcinoma of the vulva: report of two cases managed at Kenyatta National Hospital, and literature review. (2076685)
1990
33
Verrucous carcinoma of the maxillary antrum. (2715699)
1989
34
Ackerman's tumour (Verrucous carcinoma) of the oral cavity: a histopathologic study of 426 cases. (2487477)
1989
35
Verrucous carcinoma of the esophagus. (3229394)
1988
36
Simultaneously occurring condylomata acuminata, carcinoma in situ and verrucous carcinoma of the vulva and carcinoma in situ of the cervix in a young woman. A case report. (3404512)
1988
37
Verrucous carcinoma of the nasal septum. (3572222)
1987
38
Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx. (3004723)
1986
39
Invasive verrucous carcinoma of urinary bladder treated by irradiation. (2417398)
1986
40
Verrucous carcinoma of the uterine cervix. (6715942)
1984
41
Subungual keratoacanthoma: a variant of verrucous squamous cell carcinoma of the skin. (6679793)
1983
42
Verrucous carcinoma of the uterine cervix. (7431359)
1980
43
Verrucous carcinoma of urinary bladder. (7395022)
1980
44
Oral florid papillomatosis (verrucous carcinoma). (511422)
1979
45
Chemosurgery for verrucous carcinoma. (571444)
1979
46
Hemoptysis and supraglottic verrucous carcinoma. (891429)
1977
47
Verrucous carcinoma of the larynx management by radiotherapy and surgery. (949161)
1976
48
Verrucous carcinoma of the larynx. (1186399)
1975
49
Verrucous carcinoma of the buccal mucosa. (4855387)
1974
50
Verrucous carcinoma of the pyriform sinus. (4704448)
1973

Genetic Variations for Verrucous Carcinoma

Expression for genes affiliated with Verrucous Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Verrucous Carcinoma

Search GEO for disease gene expression data for Verrucous Carcinoma.

Pathways for genes affiliated with Verrucous Carcinoma

Sources:
52QIAGEN, 54Reactome, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 56SinoBiological, 30KEGG, 4Cell Signaling Technology, 50PharmGKB
See all sources

Pathways related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB3
210.2CDKN1A, MDM2
310.1ERBB3, CDKN1A, MDM2
410.0CDKN1A, MDM2, CCND1
5
Transcription Androgen Receptor nuclear signaling
Hide members
10.0CDKN1A, CCND1, MDM2
6
Hide members
10.0CDKN1A, CCND1, MDM2
710.0CDKN2A, CDKN1A, MDM2
810.0MDM2, ERBB3, CDH1
910.0CDKN1A, MDM2, RB1
1010.0RB1, CDKN2A, MDM2
1110.0NOS2, RB1, CCND1
129.9RB1, TGFA, CCND1
13
Cell adhesion ECM remodeling
Hide members
9.9MSN, CDH1, CD44
14
Hide members
9.9CDKN1A, RB1, MDM2, CCND1
15
Hide members
9.9RB1, MDM2, CCND1, CDKN1A
169.9MDM2, CDKN1A, RB1, CCND1
17
Transcription P53 signaling pathway
Hide members
9.9CDKN1A, MDM2, CDKN2A, RB1
18
Hide members
9.9CCND1, MDM2, CDH1, CDKN1A
19
Cell cycle Cell cycle (generic schema)
Hide members
9.9RB1, CDKN1A, CDKN2A, CCND1
209.9CDKN1A, CDKN2A, RB1, CCND1
21
Hide members
9.9RB1, CDKN1A, CCND1, CDKN2A
229.9CCND1, MDM2, CDH1, RB1
239.9RB1, MDM2, CD44, CDKN1A
249.8CD44, CCND1, CDKN1A, RB1
25
Hide members
9.8CCND1, NOS2, CDKN1A, RB1
269.8MDM2, CDKN1A, TGFA, RB1
27
Hide members
9.7CCND1, MDM2, RB1, CDKN2A, CDKN1A
289.7CCND1, MDM2, RB1, CDKN1A, CDKN2A
29
Hide members
9.7CDKN1A, CCND1, MDM2, CDKN2A, RB1
30
Hide members
9.7CDKN1A, CCND1, MDM2, RB1, CDKN2A
319.7CDKN1A, RB1, CCND1, MDM2, CDKN2A
32
Hide members
9.7CCND1, MDM2, CDKN2A, CD44, CDKN1A
33
Hide members
9.7RB1, CDH1, CDKN1A, CDKN2A, MDM2
349.7CDKN1A, MDM2, CDKN2A, CD44, RB1
35
Hide members
9.7TGFA, MDM2, CDKN1A, CCND1, ERBB3
36
Hide members
9.7TGFA, CCND1, MDM2, ERBB3, CDKN1A
379.6CDKN1A, CD44, CDKN2A, MDM2, ERBB3, CCND1
38
Hide members
9.5ERBB3, MDM2, TGFA, CDKN1A, TYMP, RB1
399.5CCND1, CD44, CDKN1A, ERBB3, MSN, MDM2
40
Hide members
9.5CDKN2A, CCND1, MDM2, TGFA, CDKN1A, RB1
41
Hide members
9.5RB1, CDKN2A, TGFA, CD44, MDM2, ERBB3
42
Hide members
9.5CDH1, CDKN1A, MDM2, RB1, CCND1, HSPA4
439.1TGFA, NOS2, CDH1, CDKN1A, CDKN2A, RB1
44
Hide members
9.0TGFA, MSN, MDM2, CDKN1A, CDH1, CDKN2A

Compounds for genes affiliated with Verrucous Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7MSN
2resveratrol45 60 11 2413.7TGFA
3cycloheximide4510.6MSN, TYMP
4vincristine45 50 1112.4CCND1, RB1, TYMP
5serine4510.4CDH1, CCND1, CD44
6depsipeptide4510.3CCND1, CDKN2A, CDH1
7estradiol45 11 2412.2ERBB3, RB1, MDM2
8olomoucine45 1111.1CDKN1A, CCND1, RB1, CDKN2A
9crcs4510.1CDH1, CCND1, RB1, TYMP, CDKN2A
10roscovitine4510.0CDKN2A, CDKN1A, RB1, MDM2, CCND1
11erlotinib45 50 1112.0CDH1, ERBB3, TGFA, TYMP, CCND1
12p000014510.0CDH1, CD44, CDKN2A, TYMP, MDM2, CCND1
13irinotecan45 50 1112.0CDH1, CDKN2A, TYMP, CDKN1A, MDM2
14p002459.9MDM2, RB1, CD44, CDH1, ERBB3, TYMP
15gefitinib45 50 1111.9CCND1, TGFA, ERBB3, CDKN1A, CDH1, MDM2
16flavopiridol45 1110.9CCND1, CDKN2A, CDKN1A, MDM2, RB1, HSPA4
17thymidylate459.8CDKN1A, CCND1, MDM2, RB1, TYMP, CDKN2A
18adpribose459.8MDM2, HSPA4, CDKN1A, CCND1, RB1
19formaldehyde45 2410.8CCND1, TGFA, RB1, CDH1, CD44, TYMP
20gemcitabine45 50 1111.7TYMP, ERBB3, CDKN1A, CCND1, HSPA4
21geldanamycin45 50 60 1112.7CDKN1A, MDM2, CCND1, HSPA4, CDH1
22dexamethasone45 50 29 1112.7SPRR1B, CDH1, CDKN2A, RB1, HSPA4, MDM2
23curcumin459.7NOS2, CDKN1A, CCND1, CDH1, MDM2, HSPA4
24methotrexate45 50 1111.7CDKN2A, CDH1, TYMP, CCND1, RB1, MDM2
25calcitriol45 60 11 2412.7RB1, KRT10, CD44, TGFA, CDH1, CDKN1A
26mg 13245 6010.7CDH1, CCND1, CDKN1A, HSPA4, MDM2, NOS2
27bromodeoxyuridine459.7HSPA4, CD44, RB1, CDKN1A, KRT10, TGFA
28rapamycin459.6TGFA, CDKN1A, MDM2, RB1, CDH1, ERBB3
29etoposide45 50 60 1112.6MDM2, RB1, CD44, CDH1, TGFA
30cisplatin45 50 60 1112.6MDM2, RB1, TYMP, CDKN2A, CDH1, CDKN1A
31adriamycin459.6CDH1, CDKN1A, CD44, CDKN2A, RB1, MDM2
32steroid459.5CDKN2A, CCND1, RB1, CD44, KRT10, ERBB3
335fluorouracil459.5HSPA4, TGFA, CDKN1A, CDH1, TYMP, RB1
34pd 98,059459.5CDH1, MDM2, RB1, TGFA, CCND1, HSPA4
35tamoxifen45 50 29 1112.5CDH1, TGFA, ERBB3, CDKN1A, CD44, TYMP
36paclitaxel45 50 1111.5CDKN2A, CDH1, CD44, RB1, CDKN1A, TYMP
37paraffin459.5HSPA4, CDH1, CDKN1A, ERBB3, TGFA, CD44
38p003459.4MDM2, CDH1, CD44, TYMP, RB1
39agar459.4TGFA, HSPA4, CCND1, CDKN1A, CDH1, CDKN2A
40matrigel459.4CDH1, TGFA, CD44, CCND1, TYMP, RB1
41actinomycin d459.3RB1, TYMP, MDM2, HSPA4, TGFA, NOS2
42testosterone45 60 11 2412.3RB1, CD44, CDKN2A, ERBB3, MDM2, CCND1
43genistein45 29 60 2 11 2414.2HSPA4, CCND1, MDM2, RB1, CDKN2A, CDKN1A
44oligonucleotide459.1TGFA, ERBB3, MSN, CCND1, MDM2, CDKN1A
45ly294002459.1CDH1, HSPA4, CCND1, MDM2, RB1, TYMP
46retinoic acid45 2410.0CDKN1A, CDH1, CD44, CDKN2A, CCND1, HSPA4
47progesterone45 60 29 11 2413.0CCND1, CDKN2A, CD44, CDH1, CDKN1A, MDM2
48doxorubicin45 50 1110.9NOS2, CDKN1A, CDH1, ERBB3, TGFA, CD44
49vegf458.9CDKN1A, CDH1, NOS2, ERBB3, HSPA4, CD44
50tyrosine458.9MSN, TGFA, TYMP, ERBB3, RB1, CD44

GO Terms for genes affiliated with Verrucous Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.2CDKN1A, CCND1
2basolateral plasma membraneGO:0163239.3TGFA, ERBB3, MSN, CDH1, CD44

Biological processes related to Verrucous Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to magnesium ionGO:03202610.2CCND1, MDM2
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.2CD44, MDM2
3keratinocyte differentiationGO:03021610.1SPRR1B, SPRR3, KRT10
4wound healingGO:04206010.0ERBB3, SPRR3, TGFA
5epidermal growth factor receptor signaling pathwayGO:00717310.0TGFA, MDM2, CDKN1A, ERBB3
6Ras protein signal transductionGO:0072659.9RB1, CDKN2A, CDKN1A
7response to iron ionGO:0100399.9CCND1, MDM2
8response to drugGO:0424939.8CDKN1A, TGFA, CDH1, CCND1, MDM2

Molecular functions related to Verrucous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1A, CDKN2A

Products for genes affiliated with Verrucous Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Verrucous Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet