MCID: VRT001
MIFTS: 34

Vertebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Vertebral Artery Occlusion

MalaCards integrated aliases for Vertebral Artery Occlusion:

Name: Vertebral Artery Occlusion 12 14 69
Occlusion and Stenosis of Vertebral Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11299
ICD10 33 I65.0
ICD9CM 35 433.2
UMLS 69 C0155724

Summaries for Vertebral Artery Occlusion

MalaCards based summary : Vertebral Artery Occlusion, also known as occlusion and stenosis of vertebral artery, is related to sulfhemoglobinemia and hyperthyroidism. An important gene associated with Vertebral Artery Occlusion is AARS (Alanyl-TRNA Synthetase), and among its related pathways/superpathways are GDNF-Family Ligands and Receptor Interactions and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Argatroban and Heparin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are growth/size/body region and integument

Related Diseases for Vertebral Artery Occlusion

Diseases related to Vertebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 sulfhemoglobinemia 10.5 F3 PLG
2 hyperthyroidism 10.5 F3 PLG
3 pyridoxine deficiency anemia 10.5 F3 PLG
4 myiasis 10.5 F3 PLG
5 rectum neuroendocrine neoplasm 10.5 F3 PLG
6 midline cystocele 10.5 F3 PLG
7 fallopian tube adenomatoid tumor 10.5 BDNF NTRK2
8 brain stem glioma 10.4 F3 PLG
9 psychologic vaginismus 10.4 BDNF NOS2
10 otospondylomegaepiphyseal dysplasia 10.4 F3 PLG
11 central nervous system germ cell tumor 10.4 F3 PLG
12 cervicitis 10.4
13 arcus senilis 10.3 F3 PLG SLC25A16
14 uterine inversion 10.2 F3 SLC25A16
15 parasitic helminthiasis infectious disease 10.2 F3 PLG
16 aneurysm 10.2
17 optic nerve neoplasm 10.2 CSF2 F3
18 lujo hemorrhagic fever 10.1 F3 PLG
19 capillary hemangioma 10.1 F3 PLG SST
20 aryepiglottic fold cancer 10.1 F3 PLG SST
21 idiopathic generalized epilepsy 10.1 BDNF NTRK2 SST
22 unverricht-lundborg syndrome 10.1 MRAS SLC25A16
23 vertebrobasilar insufficiency 10.0
24 coccidioidomycosis 9.9 FOSB PLG SLC25A16
25 prostate carcinoma in situ 9.8 BDNF CSF2 NOS2 RBFOX3
26 osteochondroma 9.8
27 headache 9.8
28 ischemia 9.8
29 lateral medullary syndrome 9.8
30 rheumatoid arthritis 9.8
31 brain stem infarction 9.8
32 arthritis 9.8
33 thrombosis 9.7
34 bow hunter's stroke 9.7
35 acute cervicitis 9.7
36 inflammatory linear verrucous epidermal nevus 9.7
37 intracranial aneurysm 9.7
38 vestibular neuronitis 9.7
39 locked-in syndrome 9.7
40 head injury 9.7
41 basilar artery occlusion 9.7
42 atlantoaxial subluxation 9.7
43 spondylosis 9.7
44 cerebritis 9.7
45 neuronitis 9.7
46 hydrocephalus 9.7
47 carotid artery dissection 9.7
48 hemidystonia 9.7
49 neurofibroma 9.7
50 heart disease 9.6 FOSB SDSL

Graphical network of the top 20 diseases related to Vertebral Artery Occlusion:



Diseases related to Vertebral Artery Occlusion

Symptoms & Phenotypes for Vertebral Artery Occlusion

MGI Mouse Phenotypes related to Vertebral Artery Occlusion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 F3 FOSB NOS2 NTRK2 PLG SOCS2
2 integument MP:0010771 9.7 AARS BDNF CSF2 F3 NOS2 PLG
3 nervous system MP:0003631 9.61 AARS BDNF CSF2 F3 FOSB NOS2
4 respiratory system MP:0005388 9.17 BDNF CSF2 F3 NOS2 NTRK2 PLG

Drugs & Therapeutics for Vertebral Artery Occlusion

Drugs for Vertebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Argatroban Approved, Investigational Phase 4 74863-84-6 152951
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Prilocaine Approved Phase 4 721-50-6 4906
4
Ropivacaine Approved Phase 4,Phase 2 84057-95-4 71273 175805
5 Anticoagulants Phase 4
6 Antithrombin III Phase 4
7 Antithrombins Phase 4
8 calcium heparin Phase 4
9 Calcium, Dietary Phase 4
10 Fibrinolytic Agents Phase 4,Phase 2
11 HIV Protease Inhibitors Phase 4
12 Platelet Aggregation Inhibitors Phase 4
13
protease inhibitors Phase 4
14 Serine Proteinase Inhibitors Phase 4
15 Anesthetics Phase 4,Phase 2
16 Anesthetics, Local Phase 4,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 2
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 serine Nutraceutical Phase 4
20 Tissue Plasminogen Activator Phase 3,Phase 2
21
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
22 Anti-Arrhythmia Agents Phase 2
23 Diuretics, Potassium Sparing Phase 2
24 Sodium Channel Blockers Phase 2
25 Plasminogen Phase 2
26
Menthol Approved 2216-51-5 16666
27
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
28 Hemostatics

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Argatroban for Preventing Occlusion and Restenosis After Extracranial Vertebral Artery Stenting Completed NCT01980316 Phase 4 Argatroban;non-argatroban treated group
2 Influence of the Concentration of the Local Anesthetic Ropivacaine on the Quality of a Ultrasound Guided Intermediate Cervical Block. Completed NCT01759940 Phase 4 ropivacaine 0,375%;ropivacaine 0,75%
3 Basilar Artery International Cooperation Study Recruiting NCT01717755 Phase 3
4 Superior Hypogastric Nerve Block for Pain Control Post-UFE Recruiting NCT02270255 Phase 2 0.75% Ropivacaine;1% Xylocaine
5 Thrombolysis in Ischemic Spinal Cord Stroke Active, not recruiting NCT02242084 Phase 2 Intravenuse Alteplase
6 Images in Extracranial Artery Stenosis Unknown status NCT00173927
7 Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain Completed NCT02667821
8 Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCI™]) Completed NCT00318071
9 Feasibility of Perioperative Stellate Ganglion Blocks in Cardiac Surgery Completed NCT02784587
10 Oxygen Concentration and Recovery After Carotid Endarterectomy Completed NCT02991976
11 The REFLECT Trial: Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation Recruiting NCT02536196
12 Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential Recruiting NCT03291652
13 Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure Not yet recruiting NCT02365974
14 DIVERT: Diversion of Flow in Intracranial VErtebral and Blood Blister-like Ruptured Aneurysms Trial: A Randomized Trial Comparing Pipeline Flow Diversion and Best-Standard-Treatment Withdrawn NCT01976026

Search NIH Clinical Center for Vertebral Artery Occlusion

Genetic Tests for Vertebral Artery Occlusion

Anatomical Context for Vertebral Artery Occlusion

MalaCards organs/tissues related to Vertebral Artery Occlusion:

39
Spinal Cord, Brain, Bone

Publications for Vertebral Artery Occlusion

Articles related to Vertebral Artery Occlusion:

(show top 50) (show all 139)
id Title Authors Year
1
Evaluation of a Traumatic Vertebral Artery Occlusion. ( 28254602 )
2017
2
Cryptic Recanalization of Chronic Vertebral Artery Occlusion by Head Rotation. ( 28117210 )
2017
3
Temporary vertebral artery occlusion after C3 fracture dislocation injury and spontaneous resolution following reduction and instrumented fusion: case report and literature review. ( 27798854 )
2016
4
Therapeutic internal carotid or vertebral artery occlusion using the WEB device. ( 26861025 )
2016
5
Combined use of intraoperative indocyanine green and dynamic angiography in rotational vertebral artery occlusion. ( 27041076 )
2016
6
Delayed bilateral vertebral artery occlusion after cervical spine injury: a case report. ( 28053772 )
2016
7
Bilateral vertebral artery occlusion without headache in giant cell arteritis. ( 27508209 )
2016
8
Vertebral artery occlusion and recanalization after cervical facet dislocation. ( 27535628 )
2016
9
Bilateral sub-axial rotational vertebral artery occlusion in a setting of a prior cervical construct. ( 27609452 )
2016
10
Duplex Ultrasonography-Detected Positional Vertebral Artery Occlusion in Upper Cervical Rheumatoid Arthritis. ( 26583470 )
2016
11
Congenital Spinal Malformation and Stroke: Aneurysmal Dilatations and Bilateral Rotational Vertebral Artery Occlusion. ( 26679068 )
2016
12
Corrective spinal surgery may be protective against stroke in patients with blunt traumatic vertebral artery occlusion. ( 26186525 )
2015
13
Rotational vertebral artery occlusion syndrome: Misnomers and classification. ( 25660966 )
2015
14
Wake-up stroke in a young woman with rotational vertebral artery occlusion due to far-lateral cervical disc herniation. ( 25932602 )
2015
15
A Novel Canine Model of Acute Vertebral Artery Occlusion. ( 26545253 )
2015
16
Ruptured Anterior Spinal Artery Aneurysm Associated with Bilateral Vertebral Artery Occlusion Treated by Surgical Clipping. ( 26079782 )
2015
17
Bilateral Medial Medullary Infarction with Nondominant Vertebral Artery Occlusion. ( 26175270 )
2015
18
Fusion surgery for recurrent cerebellar infarctions due to bilateral atlantoaxial rotational vertebral artery occlusion. ( 24918470 )
2014
19
Fusion Surgery for Recurrent Cerebellar Infarctions due to Bilateral Atlanto-axial Rotational Vertebral Artery Occlusion. ( 24732857 )
2014
20
Preoperative visualization of the marginal tentorial artery as an unusual collateral pathway in a patient with symptomatic bilateral vertebral artery occlusion undergoing arterial bypass surgery: A 7.0-T magnetic resonance imaging study. ( 25422785 )
2014
21
Delayed Brain Infarction due to Bilateral Vertebral Artery Occlusion Which Occurred 5 Days after Cervical Trauma. ( 25328652 )
2014
22
Evaluation of Rotational Vertebral Artery Occlusion Using Ultrasound Facilitates the Detection of Arterial Dissection in the Atlas Loop. ( 25307799 )
2014
23
Distal embolic brain infarction due to recanalization of asymptomatic vertebral artery occlusion resulting from cervical spine injury: a case report. ( 25435840 )
2014
24
Rotational vertebral artery occlusion secondary to adjacent-level degeneration following anterior cervical discectomy and fusion. ( 24745352 )
2014
25
Spontaneous atraumatic vertebral artery occlusion due to physiological cervical extension: case report. ( 24438424 )
2014
26
Upbeat nystagmus during head rotation in rotational vertebral artery occlusion. ( 24691903 )
2014
27
Atypical Anterior Spinal Artery Infarction due to Left Vertebral Artery Occlusion Presenting with Bilateral Hand Weakness. ( 24829605 )
2014
28
Endovascular reconstruction of vertebral artery occlusion prior to basilar thrombectomy in a series of six patients presenting with acute symptomatic basilar thrombosis. ( 23737492 )
2013
29
Impact of contralateral carotid or vertebral artery occlusion in patients undergoing carotid endarterectomy or carotid artery stenting. ( 24360588 )
2013
30
A Ruptured Aneurysm Arising at the Leptomeningeal Collateral Circulation from the Extracranial Vertebral Artery to the Posterior Inferior Cerebellar Artery Associated with Bilateral Vertebral Artery Occlusion. ( 24321776 )
2013
31
Coronary subclavian steal from a left internal thoracic artery coronary bypass graft due to ipsilateral subclavian artery stenosis and an arteriovenous graft in a hemodialysis patient with left vertebral artery occlusion. ( 23728554 )
2013
32
Endovascular angioplasty for extracranial vertebral artery occlusion without visualization of the stump of the artery ostium. ( 23803622 )
2013
33
Rotational vertebral artery occlusion: mechanisms and long-term outcome. ( 23696552 )
2013
34
Traumatic, high-cervical, coronal-plane spondyloptosis with unilateral vertebral artery occlusion: treatment using a prophylactic arterial bypass graft, open reduction, and instrumented segmental fusion. ( 24286529 )
2013
35
Rotational vertebral artery occlusion associated with occipitoatlantal assimilation, atlantoaxial subluxation, and basilar impression. ( 23287744 )
2013
36
Bilateral mechanical rotational vertebral artery occlusion. ( 23465174 )
2013
37
Osteochondroma of C1 causing vertebral artery occlusion. ( 22844969 )
2013
38
Death due to extensive cervicomedullary infarction following iatrogenic vertebral artery occlusion. ( 22350824 )
2012
39
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. ( 21756312 )
2011
40
Vertebral artery occlusion with Amplatzer vascular plug 4 to prevent subsequent endoleak in stent-graft treatment of subclavian artery gunshot injury. ( 21724841 )
2011
41
Stenting of a symptomatic long-segment extracranial vertebral artery occlusion. ( 21990790 )
2011
42
Dominant vertebral artery occlusion during ipsilateral head tilt. ( 21555738 )
2011
43
A rare complication of a unilateral vertebral artery occlusion, which resulted in a basilar emboli after a C5-C6 bifacet dislocation in a professional rugby player: case study. ( 21377596 )
2011
44
Impact of carotid disease on posterior circulation in patients with vertebral artery occlusion--a functional transcranial Doppler study. ( 22141282 )
2011
45
Traumatic Carotid Artery Dissection and Bilateral Vertebral Artery Occlusion after a Horse Attack: An Unusual Combination and Etiology. ( 21830193 )
2011
46
Clinical outcome of patients with acute posterior circulation stroke and bilateral vertebral artery occlusion. ( 22518265 )
2011
47
Rotational vertebral artery occlusion-series of 9 cases. ( 20881570 )
2010
48
Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. ( 20959996 )
2010
49
Artery-to-artery embolism with a mobile mural thrombus due to rotational vertebral artery occlusion. ( 19021833 )
2010
50
Giant vertebrobasilar aneurysm treated with bilateral vertebral artery occlusion. Two case reports. ( 24148641 )
2010

Variations for Vertebral Artery Occlusion

Expression for Vertebral Artery Occlusion

Search GEO for disease gene expression data for Vertebral Artery Occlusion.

Pathways for Vertebral Artery Occlusion

Pathways related to Vertebral Artery Occlusion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.55 BDNF MRAS NTRK2
2 11.34 BDNF NTRK2 SST
3 9.77 BDNF NTRK2

GO Terms for Vertebral Artery Occlusion

Biological processes related to Vertebral Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.13 AARS BDNF NTRK2
2 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.62 BDNF NTRK2

Sources for Vertebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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