MCID: VSC005
MIFTS: 50

Vesicoureteral Reflux malady

Genetic diseases, Fetal diseases, Rare diseases categories

Summaries for Vesicoureteral Reflux

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Vesicoureteral reflux (VUR) is an abnormal backward movement of urine from the bladder into ureters or... more...

MalaCards: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to pyelonephritis and hydronephrosis. An important gene associated with Vesicoureteral Reflux is VUR (Vesicoureteral reflux). The compounds calcium oxalate and oxalate have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord, and related mouse phenotypes are cardiovascular system and mortality/aging.

Description from OMIM:48 610878,614674,193000,314550

Aliases & Classifications for Vesicoureteral Reflux

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9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases


Aliases & Descriptions:

vesicoureteral reflux 9 10 48 11 46
vesico-ureteral reflux 9 63


External Ids:

Disease Ontology9 DOID:9620
MeSH36 D014718
ICD9CM28 593.7
NCIt41 C84467

Related Diseases for Vesicoureteral Reflux

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Vesicoureteral Reflux 2 family:

vesicoureteral reflux Vesicoureteral Reflux 1
Vesicoureteral Reflux 4 Vesicoureteral Reflux 3
Vesicoureteral Reflux 7 Vesicoureteral Reflux 5
Vesicoureteral Reflux 6

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.1UMOD, NAGLU
2hydronephrosis31.0NAGLU, AGTR2
3vesicoureteral reflux 231.0ROBO2
4urinary tract obstruction30.4NAGLU, UMOD
5chronic pyelonephritis30.4NAGLU, UMOD
6renal agenesis30.4AGTR2, PAX2
7cystitis30.2NAGLU, UMOD
8nephrocalcinosis30.2NAGLU, UMOD
9focal segmental glomerulosclerosis30.2PAX2, NAGLU
10proteinuria30.0NAGLU, PAX2, UMOD, AGTR2
11urethritis10.7
12neurogenic bladder10.7
13posterior urethral valves10.7
14posterior urethral valve10.7
15acute pyelonephritis10.6
16ureterocele10.5
17ureteral obstruction10.5
18polyhydramnios10.5
19hypertension10.4
20renal coloboma syndrome10.4
21epispadias10.4
22vesicoureteral reflux 110.4
23vesicoureteral reflux 310.4
24hirschsprung's disease10.3
25pseudohypoaldosteronism10.3
26detrusor sphincter dyssynergia10.3
27hydrocephalus10.3
28vascular malformation multi-gene panels10.3
29transient pseudohypoaldosteronism10.3
30trigonitis10.3
31bladder diverticulum10.3
32urethral obstruction10.3
33vesicoureteral reflux 410.3
34urofacial syndrome 110.3
35vesicoureteral reflux 710.3
36vesicoureteral reflux 510.3
37vesicoureteral reflux 610.3
38blindness10.3
39exstrophy-epispadias complex10.3
40renal dysplasia10.3
41renal hypoplasia10.3
42hinman syndrome10.3
43williams-beuren syndrome10.1
44perinephritis10.1
45bacteriuria10.1
46charge syndrome10.1
47matthew-wood syndrome10.1
48hypospadias10.1
49microcephaly10.1
50end stage renal failure10.1

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to vesicoureteral reflux

Symptoms for Vesicoureteral Reflux

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48OMIM
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Clinical features from OMIM:

610878,614674,193000,314550

Drugs & Therapeutics for Vesicoureteral Reflux

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Vesicoureteral Reflux

Drug clinical trials:

Search ClinicalTrials for Vesicoureteral Reflux

Search NIH Clinical Center for Vesicoureteral Reflux

Search CenterWatch for Vesicoureteral Reflux

Genetic Tests for Vesicoureteral Reflux

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Anatomical Context for Vesicoureteral Reflux

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34MalaCards
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MalaCards organs/tissues related to Vesicoureteral Reflux:

34
Kidney, Testes, Spinal cord

Animal Models for Vesicoureteral Reflux or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Vesicoureteral Reflux:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8NAGLU, PAX2, ROBO2, AGTR2
2MP:00107687.7SOX17, NAGLU, PAX2, ROBO2, AGTR2
3MP:00053677.1NAGLU, PAX2, UPK3A, UMOD, ROBO2, AGTR2

Publications for Vesicoureteral Reflux

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53PubMed
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Articles related to Vesicoureteral Reflux:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Prospective study using a new bulking agent for the treatment of vesicoureteral reflux: polyacrylamide hydrogel. (23538241)
2013
2
Carbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux model. (24005825)
2013
3
Practice patterns among pediatric urologists in the use of DefluxAr for vesicoureteral reflux: a survey. (23466044)
2013
4
Evaluation of children with urinary tract infection - Impact of the 2011 AAP guidelines on the diagnosis of vesicoureteral reflux using a historical series. (24063867)
2013
5
Acute and delayed vesicoureteral obstruction after endoscopic treatment of primary vesicoureteral reflux with dextranomer/hyaluronic acid copolymer: why and how to manage. (23507288)
2013
6
The RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux. (23753091)
2013
7
Predictive Risk Factors in Childhood Urinary Tract Infection, Vesicoureteral Reflux, and Renal Scarring Management. (24366998)
2013
8
Relationship among bacterial virulence, bladder dysfunction, vesicoureteral reflux and patterns of urinary tract infection in children. (22595065)
2012
9
Renal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux. (22080623)
2012
10
Association of nocturnal enuresis with vesicoureteral reflux and renal cortical damage. (23573464)
2012
11
Presence of dextranomer-hyaluronic acid (DxHA) mound on postoperative ultrasound does not predict resolution of vesicoureteral reflux. (21672652)
2011
12
Vesicoureteral reflux in children: a phantom study of microwave heating and radiometric thermometry of pediatric bladder. (21900069)
2011
13
Surgical Reimplantation for the Correction of Vesicoureteral Reflux following Failed Endoscopic Injection. (21274435)
2011
14
New noninvasive methods to diagnose vesicoureteral reflux. (21519276)
2011
15
Can we rely on the presence of dextranomer-hyaluronic acid copolymer mounds on ultrasound to predict vesicoureteral reflux resolution after injection therapy? (21555031)
2011
16
Predictors of surgical outcome in children with vesicoureteral reflux associated with paraureteral diverticula. (20189227)
2010
17
Vesicoureteral reflux in children with urinary tract infection: comparison of diagnostic accuracy of renal US criteria. (20501726)
2010
18
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
19
Is there a learning curve for subureteric injection of dextranomer/hyaluronic acid in the treatment of vesicoureteral reflux? (19740702)
2010
20
The Swedish reflux trial in children: II. Vesicoureteral reflux outcome. (20488469)
2010
21
Re: Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux. Editorial comment. (20650498)
2010
22
Cross-sectional evaluation of parental decision making factors for vesicoureteral reflux management in children. (20728107)
2010
23
The value of estimation of distal ureteral dilatation in primary vesicoureteral reflux. (20495700)
2010
24
Editorial comment to efficacy of endoscopic subureteral injection for vesicoureteral reflux in adults with decreased bladder compliance. (20590949)
2010
25
Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux? (19438835)
2009
26
Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection. (19968584)
2009
27
Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity in children with vesicoureteral reflux. (19408836)
2009
28
Validation of a prognostic calculator for prediction of early vesicoureteral reflux resolution in children. (19539324)
2009
29
Investigation of histopathologic changes in the ureter walls in vesicoureteral reflux. (19361644)
2009
30
Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. (18604293)
2008
31
Microalbuminuria in children with vesicoureteral reflux. (18661415)
2008
32
A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. (18197425)
2008
33
Vesicoureteral reflux. (18322164)
2008
34
Mini-ureteroneocystostomy: a safe and effective outpatient treatment for unilateral vesicoureteral reflux. (18708210)
2008
35
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators. (19018047)
2008
36
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. (17357069)
2007
37
Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. (18074194)
2007
38
Pediatric vesicoureteral reflux: treatment patterns and outcomes. (17667907)
2007
39
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
40
Predictive value of clinical factors for successful endoscopic correction of primary vesicoureteral reflux grades III-IV. (18947678)
2006
41
Loss of interstitial cells of Cajal and gap junction protein connexin 43 at the vesicoureteral junction in children with vesicoureteral reflux. (16217373)
2005
42
Management of vesicoureteral reflux secondary to neurogenic bladder. (9799381)
1998
43
An alternative ureteroileal reimplantation used in augmentation cystoplasty for neurogenic bladder with bilateral vesicoureteral reflux. (9751368)
1998
44
Renal tubular acidosis in children with vesicoureteral reflux. (8648800)
1996
45
Incidence of vesicoureteral reflux in children with unilateral renal agenesis. (7869521)
1995
46
Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux. (8154076)
1994
47
Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infection? (8284391)
1994
48
Urinary Tamm-Horsfall protein excretion in patients with primary vesicoureteral reflux. (1915538)
1991
49
Initiation of vesicoureteral reflux after heminephrectomy for ureterocele. (2929061)
1989
50
EXPERIMENTAL BLADDER NECK OBSTRUCTION. I. INCIDENCE OF VESICOURETERAL REFLUX, UPPER TRACT DILATION, AND URINARY INFECTION IN RABBITS. (14078534)
1963

Variations for Vesicoureteral Reflux

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Expression for genes affiliated with Vesicoureteral Reflux

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vesicoureteral Reflux

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Pathways for genes affiliated with Vesicoureteral Reflux

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Compounds for genes affiliated with Vesicoureteral Reflux

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1calcium oxalate469.6UMOD, NAGLU
2oxalate469.6UMOD, NAGLU
3enalapril46 52 1211.6AGTR2, NAGLU
4losartan46 52 30 1212.5NAGLU, AGTR2
5colchicine46 62 3 30 1213.4UMOD, NAGLU
6uric acid46 2510.4UMOD, NAGLU
7sulfate46 2510.3NAGLU, UMOD
8citrate469.3UMOD, NAGLU
9urea46 25 1211.2UMOD, NAGLU
10sialic acid469.0UMOD, NAGLU
11sodium46 2510.0NAGLU, UMOD, AGTR2
12creatinine469.0AGTR2, UMOD, NAGLU

GO Terms for genes affiliated with Vesicoureteral Reflux

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17Gene Ontology
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Cellular components related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.5ROBO2, UMOD, UPK3A, NAGLU

Biological processes related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell growthGO:0303089.5AGTR2, SOX17
2regulation of metanephros sizeGO:0355669.2AGTR2, PAX2
3positive regulation of metanephric glomerulus developmentGO:0723009.2AGTR2, PAX2
4metanephric distal convoluted tubule developmentGO:0722219.1UMOD, PAX2
5positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0PAX2, AGTR2
6positive regulation of transcription, DNA-templatedGO:0458938.4AGTR2, PAX2, SOX17

Products for genes affiliated with Vesicoureteral Reflux

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  • Antibodies
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Sources for Vesicoureteral Reflux

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet