MCID: VSC005
MIFTS: 51

Vesicoureteral Reflux malady

Summaries for Vesicoureteral Reflux

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Vesicoureteral reflux (VUR) is an abnormal movement of urine from the bladder into ureters or kidneys.... more...

MalaCards: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to pyelonephritis and hydronephrosis. An important gene associated with Vesicoureteral Reflux is VUR (Vesicoureteral reflux), and among its related pathways are Renin-angiotensin system and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord, and related mouse phenotype renal/urinary system.

Description from OMIM:46 314550,193000,614674,610878

Aliases & Classifications for Vesicoureteral Reflux

About this section
Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
See all sources

Aliases & Descriptions:

vesicoureteral reflux 8 9 46 10 44
vesico-ureteral reflux 8 60


External Ids:

Disease Ontology8 DOID:9620
MeSH34 D014718
ICD9CM27 593.7
NCIt39 C84467

Related Diseases for Vesicoureteral Reflux

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Vesicoureteral Reflux 2 family:

vesicoureteral reflux Vesicoureteral Reflux 1
Vesicoureteral Reflux 4 Vesicoureteral Reflux 3
Vesicoureteral Reflux 7 Vesicoureteral Reflux 5
Vesicoureteral Reflux 6

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.0UMOD, AMBP, NAGLU
2hydronephrosis30.9AGTR2, PLEKHF1, NAGLU
3ureteral obstruction30.7AMBP, AGTR1
4urinary tract obstruction30.6NAGLU, AMBP, UMOD
5hypertension30.6AGT, AGTR1, KLK1
6renal agenesis30.3AGTR2, PAX2
7chronic pyelonephritis30.3NAGLU, UMOD
8focal segmental glomerulosclerosis30.1PAX2, AGTR1, NAGLU
9cystitis30.1NAGLU, UMOD, UPK2, UPK1A
10proteinuria30.1AGTR1, NAGLU, AMBP, AGTR2, AGT, PAX2
11urethritis10.7
12neurogenic bladder10.6
13acute pyelonephritis10.6
14ureterocele10.5
15vesicoureteral reflux 210.5
16renal coloboma syndrome10.4
17polyhydramnios10.4
18vesicoureteral reflux 310.3
19pseudohypoaldosteronism10.3
20detrusor sphincter dyssynergia10.3
21hirschsprung's disease10.3
22hydrocephalus10.3
23ureteral disease10.3
24vascular malformation multi-gene panels10.3
25trigonitis10.2
26urethral syndrome10.2
27bladder diverticulum10.2
28renal hypertension10.2
29urethral obstruction10.2
30vesicoureteral reflux 110.2
31vesicoureteral reflux 410.2
32urofacial syndrome 110.2
33vesicoureteral reflux 710.2
34vesicoureteral reflux 510.2
35vesicoureteral reflux 610.2
36thrombocytopenia-absent radius syndrome10.1
37klippel-trenaunay syndrome10.1
38bacteriuria10.1
39perinephritis10.1
40williams-beuren syndrome10.1
41cutis laxa10.1
42fanconi's anemia10.1
43alstrom syndrome10.1
44trichorhinophalangeal syndrome type ii10.1
45coloboma10.1
46digeorge syndrome10.1
47wolf-hirschhorn syndrome10.1
48bladder neck obstruction10.1
49microcephaly10.1
50matthew-wood syndrome10.1

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to vesicoureteral reflux

Clinical Features for Vesicoureteral Reflux

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

314550,193000,614674,610878

Drugs & Therapeutics for Vesicoureteral Reflux

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vesicoureteral Reflux

Drug clinical trials:

Search ClinicalTrials for Vesicoureteral Reflux

Search NIH Clinical Center for Vesicoureteral Reflux

Search CenterWatch for Vesicoureteral Reflux

Genetic Tests for Vesicoureteral Reflux

About this section

Anatomical Context for Vesicoureteral Reflux

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Vesicoureteral Reflux:

32
Kidney, Testes, Spinal cord

Animal Models for Vesicoureteral Reflux or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Vesicoureteral Reflux:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.8PAX2, UPK2, UPK3A, AGTR2, AGTR1, AGT

Publications for Vesicoureteral Reflux

About this section
Sources:
50PubMed
See all sources

Articles related to Vesicoureteral Reflux:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Evaluation of children with urinary tract infection - Impact of the 2011 AAP guidelines on the diagnosis of vesicoureteral reflux using a historical series. (24063867)
2013
2
The RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux. (23753091)
2013
3
Re: Distal ureteral diameter measurement objectively predicts vesicoureteral reflux outcome. (24120813)
2013
4
Long-term incidence of urinary tract infection after ureteral reimplantation for primary vesicoureteral reflux. (22261484)
2013
5
Presence of vesicoureteral reflux in the graft kidney does not adversely affect long-term graft outcome in kidney transplant recipients. (24157018)
2013
6
Interleukin-18, CRP and procalcitonin levels in vesicoureteral reflux and reflux nephropathy. (23957657)
2013
7
Outcomes of targeted treatment for vesicoureteral reflux in children with nonneurogenic lower urinary tract dysfunction. (23473909)
2013
8
Commentary to 'Long-term results of endoscopic treatment of vesicoureteral reflux in children with different materials'. (22373654)
2013
9
Downgrading of high-grade vesicoureteral reflux is a reliable option in the treatment of children with grade IVa89V reflux accompanied by breakthrough infections. (22391110)
2013
10
Is intraoperative surgeon's opinion an accurate tool to assess the outcome of endoscopic treatment for vesicoureteral reflux? (23731563)
2013
11
Risk factors for renal scarring in children with primary vesicoureteral reflux disease. (23640645)
2013
12
Re: Hypertension in pediatric patients with renal scarring in association with vesicoureteral reflux. (24120812)
2013
13
Childhood vesicoureteral reflux studies: registries and repositories sources and nosology. (23044377)
2013
14
Histology proved malpositioning of dextranomer/hyaluronic acid in submucosal ureter in patients after failed endoscopic treatment of vesicoureteral reflux. (22595062)
2012
15
Identifying children with vesicoureteral reflux: a comparison of 2 approaches. (22998917)
2012
16
Familial vesicoureteral reflux and reflux related morbidity in relatives of index patients with high grade vesicoureteral reflux. (22906681)
2012
17
Surgical Reimplantation for the Correction of Vesicoureteral Reflux following Failed Endoscopic Injection. (21274435)
2011
18
Can we rely on the presence of dextranomer-hyaluronic acid copolymer mounds on ultrasound to predict vesicoureteral reflux resolution after injection therapy? (21555031)
2011
19
Prediction of high-grade vesicoureteral reflux after pediatric urinary tract infection: external validation study of procalcitonin-based decision rule. (22216314)
2011
20
Detection of vesicoureteral reflux using microwave radiometry-system characterization with tissue phantoms. (21257366)
2011
21
Quality of life in children with vesicoureteral reflux as perceived by children and parents. (21527212)
2011
22
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
23
Re: Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux. Editorial comment. (20650502)
2010
24
Surgery Illustrated - Surgical Atlas Endoscopic treatment of vesicoureteral reflux. (20500570)
2010
25
Endoscopic vesicoureteral reflux correction in transplanted kidneys: does injection technique matter? (20626270)
2010
26
Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux? (19438835)
2009
27
Vesicoureteral reflux to the non-functional graft on a renal transplant imaging with 99mTc-DTPA. (19836859)
2009
28
Antibiotic prophylaxis in vesicoureteral reflux: A paradigm shift. (19468452)
2009
29
Update on childhood urinary tract infection and vesicoureteral reflux. (19615556)
2009
30
Commentary to "Controversies in the management of vesicoureteral reflux - the rationale for the RIVUR study". (19576855)
2009
31
PIC cystography: a selective approach to the diagnosis of vesicoureteral reflux. (19683282)
2009
32
Renin-angiotensin system polymorphisms: a risk factor for progression to end-stage renal disease in vesicoureteral reflux patients. (19288324)
2009
33
Renal parenchymal damage in intermediate and high grade infantile vesicoureteral reflux. (18708232)
2008
34
Correlation of prenatal and postnatal ultrasound findings with the incidence of vesicoureteral reflux in children with fetal renal pelvic dilatation. (18718617)
2008
35
Postoperative cystography and endoscopic treatment of low-grade vesicoureteral reflux. (18503385)
2008
36
Renal involvement in children with vesicoureteral reflux: are prenatal detection and surgical approaches preventive? (18609292)
2008
37
Voiding ultrasonography: evaluation of the detection of vesicoureteral reflux based on the review of digital ultrasound clips. (18098092)
2008
38
Relationship among vesicoureteral reflux, urinary tract infection and renal damage in children. (17574623)
2007
39
Vesicoureteral reflux after kidney transplantation in children. (17631017)
2007
40
Genetic control of VEGF and TGF-beta1 gene polymorphisms in childhood urinary tract infection and vesicoureteral reflux. (17597658)
2007
41
Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux. (17880289)
2007
42
Long-term evolution of renal damage associated with unilateral vesicoureteral reflux. (17632145)
2007
43
The deflux procedure reduces the incidence of urinary tract infections in patients with vesicoureteral reflux. (17570788)
2007
44
Renal pelvic wall thickening in childhood urinary tract infections--evidence of acute pyelitis or vesicoureteral reflux? (12745739)
2003
45
Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. (12187255)
2002
46
Molecular basis of vesicoureteral reflux]. (12244279)
2002
47
A large bladder calculus and severe vesicoureteric reflux as seen on Tc-99m MAG3 renography. (12394132)
2002
48
Absence of PAX2 gene mutations in patients with primary familial vesicoureteric reflux. (9598733)
1998
49
Endoscopic correction of vesicoureteral reflux secondary to posterior urethral valves. (8683759)
1996
50
Primary vesicoureteric reflux in neonates with imperforate anus. (7377836)
1980

Genetic Variations for Vesicoureteral Reflux

About this section

Expression for genes affiliated with Vesicoureteral Reflux

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vesicoureteral Reflux

Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for genes affiliated with Vesicoureteral Reflux

About this section
Sources:
29KEGG, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
See all sources

Pathways related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3AGT, AGTR1, AGTR2
2
Hide members
10.3AGT, AGTR1, AGTR2

Compounds for genes affiliated with Vesicoureteral Reflux

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1angiotensin iii2810.8AGTR2, AGTR1
2angiotensin i2810.8AGTR2, AGTR1
3etoperidone4410.8AGTR2, AGTR1
4Tasosartan1110.7AGTR2, AGTR1
5cgp42112a4410.7AGT, AGTR1, AGTR2
6saralasin4410.7AGTR2, AGTR1, AGT
7pd12331944 2811.7AGT, AGTR1, AGTR2
8cv 119744410.7AGTR1, AGT
9calcium oxalate4410.7AMBP, UMOD, NAGLU
1099mtc-dmsa4410.7AMBP, NAGLU
11inulin4410.7NAGLU, AGT, AMBP
12valsartan44 59 28 1113.7AGT, AGTR1, AGTR2
13amikacin4410.7AMBP, NAGLU
14telmisartan44 28 1112.7AGTR2, AGTR1, AGT
15perindopril44 49 1112.7AGTR1, AGT, NAGLU
16irbesartan44 28 49 1113.7AGT, AGTR1, AGTR2
17aliskiren44 1111.7AGT, AGTR1
18candesartan44 28 1112.7AGTR2, AGTR1, AGT
19angiotensin ii28 2411.7AGTR2, AGTR1
20losartan44 49 28 1113.7NAGLU, AGT, AGTR1, AGTR2
21dmsa4410.7AMBP, NAGLU
22captopril44 28 49 59 1114.7AGTR2, AGTR1, AGT
23ang ii4410.7AGTR2, AGTR1, AGT
24uric acid44 2411.7AMBP, UMOD, AGTR1, NAGLU
25benazepril44 1111.6AGT, AGTR1
26aprotinin44 1111.6KLK1, AMBP, AGT, NAGLU
27eprosartan44 28 1112.6AGT, AGTR1
28enalapril44 49 1112.6NAGLU, AGT, AGTR1, AGTR2, AMBP
29nifedipine44 49 28 1113.6NAGLU, AGT, AGTR1, AMBP
30iohexol4410.6NAGLU, AMBP
31kininogen4410.6CLEC3B, AMBP, KLK1
32olmesartan44 28 1112.6AGTR1, AGT
33colchicine59 44 2 28 1114.6UMOD, AGT, NAGLU
34prostaglandin4410.6AMBP, AGTR2, AGTR1, AGT
35oxalate4410.6UMOD, NAGLU
36thromboxane a244 2411.6AGTR1, AGT, NAGLU
37potassium44 11 2412.5NAGLU, AGT, AGTR1, UMOD, AMBP
38trichloroethylene4410.5AMBP, NAGLU
39sodium44 2411.5AMBP, UMOD, AGTR2, AGTR1, AGT, NAGLU
40creatinine4410.5AMBP, UMOD, AGTR2, AGTR1, AGT, NAGLU
41cyclosporin a44 28 5912.5AMBP, AGTR2, AGTR1, AGT, NAGLU
42ulinastatin4410.5AMBP, NAGLU
43lisinopril44 11 2412.5AGT, AGTR1
44heparin44 28 11 2413.5UMOD, AGTR1, AGT, NAGLU, CLEC3B
45verapamil44 49 28 11 2414.3NAGLU, AGTR1, AMBP
46sulfate44 2411.3AMBP, UMOD, NAGLU
47glucose4410.3AMBP, UMOD, AGTR1, AGT, NAGLU, INSRR
48urea44 11 2412.3NAGLU, UMOD, AMBP
49chymostatin4410.2AGT, AGTR1
50atenolol44 28 49 11 2414.0AGT, AGTR1

GO Terms for genes affiliated with Vesicoureteral Reflux

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:01632410.1UPK3A, UPK2, UPK1A, UPK1B, UMOD

Biological processes related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of metanephros sizeGO:03556610.7AGTR2, PAX2
2positive regulation of metanephric glomerulus developmentGO:07230010.7AGTR2, PAX2
3positive regulation of NAD(P)H oxidase activityGO:03386410.7AGTR1, AGT
4regulation of blood vessel size by renin-angiotensinGO:00203410.6AGTR1, AGT
5metanephric distal convoluted tubule developmentGO:07222110.6UMOD, PAX2
6renin-angiotensin regulation of aldosterone productionGO:00201810.6AGT, AGTR1, AGTR2
7cell growth involved in cardiac muscle cell developmentGO:06104910.6AGTR2, AGT
8positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.6PAX2, AGT, AGTR2
9negative regulation of neurotrophin TRK receptor signaling pathwayGO:05138710.6AGTR2, AGT
10regulation of renal sodium excretionGO:03581310.6AGTR1, AGT
11cellular sodium ion homeostasisGO:00688310.6AGTR2, AGT
12positive regulation of cholesterol esterificationGO:01087310.6AGTR1, AGT
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:00719910.6AGT, AGTR2
14epithelial cell differentiationGO:03085510.5UPK1B, UPK1A, UPK2, UPK3A
15low-density lipoprotein particle remodelingGO:03437410.5AGTR1, AGT
16kidney developmentGO:00182210.5AGT, AGTR1, UPK3A
17positive regulation of cellular protein metabolic processGO:03227010.5AGT, AGTR1
18positive regulation of renal sodium excretionGO:03581510.4AGT, AGTR2
19positive regulation of macrophage derived foam cell differentiationGO:01074410.3AGT, AGTR1
20regulation of vasoconstrictionGO:01922910.3AGT, AGTR1
21nitric oxide mediated signal transductionGO:00726310.3AGTR2, AGT
22negative regulation of cell growthGO:03030810.0AGT, AGTR2, SOX17

Molecular functions related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.4AGTR1, AGTR2
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1

Products for genes affiliated with Vesicoureteral Reflux

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vesicoureteral Reflux

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet