Vesicoureteral Reflux malady

Wikipedia: Vesicoureteral reflux (VUR) is an abnormal movement of urine from the bladder into ureters or kidneys....⁴⁴ more...

MalaCards: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to acute pyelonephritis and pyelonephritis. An important gene associated with Vesicoureteral Reflux is ROBO2 (roundabout, axon guidance receptor, homolog 2 (Drosophila)), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Development_Slit-Robo signaling. The compounds atenolol and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

vesicoureteral reflux 6 7 8 33 32 vesico-ureteral reflux 6 43

Disease types for vesicoureteral reflux family:

vesicoureteral reflux 1	vesicoureteral reflux 2
vesicoureteral reflux 3

Diseases related to vesicoureteral reflux by text searches and GeneDecks gene sharing:

(show top 50)    (show all 556)

id	Related Disease	Score	Top Affiliating Genes
1	acute pyelonephritis	29.9	NAGLU, IL6, IL8, TNF, CRP, ACE
2	pyelonephritis	29.5	NAGLU, UMOD, IL6, IL8, AMBP, TNF
3	nephropathy	25.3	REN, VUR, SERPINE1, NAGLU, VEGFA, PAX2
4	ischemia	24.4	REN, SERPINE1, NAGLU, VEGFA, IL6, IL8
5	fibrosis	22.7	REN, SERPINE1, NAGLU, VEGFA, BIRC5, UMOD
6	urinary tract obstruction	13.8	NAGLU, UMOD, AMBP
7	ovarian brenner tumor	13.8	UPK1A, UPK1B, UPK2, UPK3A
8	mitral valve disease	13.6	ACE, AGT, AGTR1
9	cystic kidney	13.6	PAX2, UMOD, HNF1B
10	urinary system disease	13.6	NAGLU, BIRC5, UMOD
11	focal segmental glomerulosclerosis	13.6	NAGLU, PAX2, ACE, AGTR1
12	lacrimal duct obstruction	13.6	PAX2, UMOD, AMBP, AGTR1, AGTR2, ADM
13	lipoid nephrosis	13.5	NAGLU, IL4R, ADM
14	diastolic heart failure	13.5	ACE, AGT, AGTR1
15	hypertensive heart disease	13.5	ACE, AGT, AGTR1
16	diabetic angiopathy	13.5	NAGLU, EDN1, ADM
17	ureteral obstruction	13.4	AMBP, AGTR1, AGTR2, TGFB1
18	myocardial stunning	13.4	EDN1, AGTR1, AGTR2
19	neurogenic bladder	13.4	MEOX2, TMEM173, PRUNE
20	aortic coarctation	13.4	EDN1, ACE, AGT, AGTR1
21	urolithiasis	13.4	NAGLU, UMOD, IL6, AMBP
22	rectal cloacogenic carcinoma	13.4	BIRC5, UPK1A, UPK1B, UPK2, UPK3A
23	hematuria	13.4	NAGLU, BIRC5, AMBP, ACE
24	posterior urethral valves	13.4	ACE, AGT, AGTR1, TGFB1
25	conn's syndrome	13.4	REN, AGTR1, AGTR2
26	postural orthostatic tachycardia syndrome	13.3	REN, AGT, AGTR1
27	multicystic renal dysplasia, bilateral	13.3	REN, PAX2, AGTR2, PRUNE
28	neurocirculatory asthenia	13.3	ACE, AGT, AGTR1, TGFB1
29	familial juvenile hyperuricemic nephropathy	13.3	REN, UMOD, HNF1B
30	horizontal gaze palsy with progressive scoliosis	13.2	ROBO1, ROBO2, ROBO3, ROBO4
31	gaze palsy	13.2	ROBO1, ROBO2, ROBO3, ROBO4
32	renal tubular dysgenesis	13.2	REN, ACE, AGT, AGTR1
33	chronic rapidly progressive glomerulonephritis	13.2	SERPINE1, NAGLU, AMBP, ACE, AGTR1, ADM
34	eisenmenger syndrome	13.2	EDN1, ACE, TGFB1
35	anuria	13.2	REN, ACE, AGT, AGTR1
36	fibromuscular dysplasia	13.1	REN, ACE, AGT, AGTR1
37	malignant hypertension	13.1	REN, ACE, ADM
38	slow-channel congenital myasthenic syndrome	13.1	IL8, CRP
39	orthostatic hypotension	13.1	REN, ACE, AGT, AGTR1
40	angioedema	13.1	IL6, KLK1, ACE, AGT, AGTR2
41	hypertension	13.1	REN, ACE, AGT, AGTR1
42	panic disorder	13.1	NAGLU, CRP, ACE, AGT, AGTR1
43	renovascular hypertension	13.1	REN, ACE, AGTR1, ADM
44	type 1 diabetes mellitus	13.1	NAGLU, AMBP, HLA-DRB1, ACE, AGT, AGTR1
45	renal agenesis	13.1	RET, NAGLU, PAX2, UPK3A, KAL1, AGTR2
46	hyperaldosteronism	13.1	REN, ACE, AGT, AGTR1
47	erythrocytosis	13.1	REN, ACE, AGT, AGTR1, AGTR2
48	usual interstitial pneumonia	13.1	IL8, AGTR1, TGFB1
49	hyperinsulinism	13.0	SERPINE1, HNF1B, EDN1, AGT, AGTR1
50	renal hypertension	13.0	REN, EDN1, ACE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to vesicoureteral reflux:

²²

MGI Mouse Phenotypes related to vesicoureteral reflux:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	SOX17, MEOX2, PAX2, RET
2	hematopoietic system phenotype	MP:0005397	9.7	FGFRL1, MEOX2, IL4R, IFNGR1, SOX17
3	respiratory system phenotype	MP:0005388	9.7	ROBO3, ROBO1, MEOX2, FGFRL1, RET
4	embryogenesis phenotype	MP:0005380	9.6	ROBO3, GFRA1, MEOX2, FGFRL1, BIRC5, RET
5	integument phenotype	MP:0010771	9.6	ROBO4, GFRA1, IFNGR1, IL4R, MEOX2
6	liver/biliary system phenotype	MP:0005370	9.1	ADM, SOX17, AGT, HNF1B, IFNGR1, IL6
7	digestive/alimentary phenotype	MP:0005381	8.8	SOX17, TGFB1, GFRA1, AGTR2, EDN1, MEOX2
8	nervous system phenotype	MP:0003631	8.8	ROBO3, TGFB1, AGTR2, AGT, EDN1, IFNGR1
9	adipose tissue phenotype	MP:0005375	8.5	TGFB1, AGTR2, AGT, ACE, TNF, IL6
10	renal/urinary system phenotype	MP:0005367	8.5	REN, ADM, ROBO2, GFRA1, AGTR2, AGTR1
11	immune system phenotype	MP:0005387	8.4	ADM, SOX17, GFRA1, AGTR1, TMEM173, TNF
12	behavior/neurological phenotype	MP:0005386	8.1	ADM, ROBO3, ROBO1, GFRA1, AGTR2, AGT
13	tumorigenesis	MP:0002006	7.8	ROBO1, TGFB1, AGTR2, ACE, TNF, IFNGR1
14	growth/size phenotype	MP:0005378	7.6	SOX17, AGTR1, AGT, ACE, HNF1B, IL6
15	reproductive system phenotype	MP:0005389	7.2	ROBO2, TGFB1, AGT, TNF, AMBP, IL6
16	muscle phenotype	MP:0005369	7.1	EDN1, AGT, AGTR2, GFRA1, TGFB1, ADM
17	homeostasis/metabolism phenotype	MP:0005376	6.6	TMEM173, CRP, EDN1, AGT, AGTR2, TGFB1
18	cellular phenotype	MP:0005384	6.3	AGTR2, GFRA1, TGFB1, ROBO1, ROBO2, ROBO3
19	cardiovascular system phenotype	MP:0005385	6.0	CRP, EDN1, ACE, AGT, AGTR1, AGTR2
20	mortality/aging	MP:0010768	4.8	AGTR1, AGT, ACE, EDN1, TMEM173, AGTR2

Articles related to vesicoureteral reflux:

(show all 47)

id	Title	Authors	Year	Affiliating Genes
1	Urinary levels of interleukin-6 and interleukin-8 in patients with vesicoureteral reflux and renal parenchymal scar. (20084405)	Gokce I.... Topuzoglu A.	2010	IL6, IL8
2	Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. (19959718)	Cordell H.J.... Goodship J.A.	2010	RET, AGTR2, PAX2
3	Screening of vesicoureteral reflux in pediatric patie nts with kidney transplantation showing non-specific interstitial fibrosis and tubular atrophy with interstitial Tamm-Horsfall protein deposits in protocol al lograft biopsy. (19594587)	Akioka Y.... Hattori M.	2009	UMOD
4	Urinary evaluation of the balance between the soluble interferon-gamma receptor (IFN-gammaR1) and the interleukin-4 receptor (IL-4Ra lpha) in children with vesicoureteral reflux. (19739012)	Okamoto Y.... Masuzawa T.	2009	IFNGR1, IL4R
5	Linkage analysis of candidate genes in families with vesicoureteral reflux. (19692025)	Kelly H.... Puri P.	2009	KAL1
6	Renin-angiotensin system polymorphisms: a risk factor for progression to end-stage renal disease in vesicoureteral reflux patients. (19288324)	Akman B.... Ozdemir F.N.	2009	ACE, AGTR2, AGTR1
7	The increased incidence of the RET p.Gly691Ser variant in French-Canadian vesicoureteric reflux patients is not replicated by a larger study in Ireland. (19306327)	Darlow J.M.... Barton D.E.	2009	RET
8	ROBO2 gene variants are associated with familial vesicoureteral reflux. (18235093)	Bertoli-Avella A.M.... Perrotta S.	2008	ROBO2
9	RET Gly691Ser mutation is associated with primary vesicoureteral reflux in the French-Canadian population from Quebec. (18273880)	Yang Y.... Richter A.	2008	RET
10	Extracellular microenvironment and cytokine profile of the ureterovesical junction in children with vesicoureteral reflux. (18554644)	Schwentner C.... Radmayr C.	2008	VEGFA, CLEC3B
11	TGF-beta1 gene polymorphisms and primary vesicoureteral reflux in childhood. (18685869)	Kowalewska-Pietrzak M.... Mlynarski W.	2008	TGFB1
12	Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. (17357069)	Lu W.... Maas R.L.	2007	ROBO2, PCDH11Y
13	Vesicoureteric reflux and tumor necrosis factor-alpha gene polymorphism. (18947693)	Pardo R.... Coto E.	2007	TNF
14	Survivin expression in the ureteral wall of high degree vesicoureteral reflux in children. (17203351)	Joseph B.... Ben-Chaim J.	2007	BIRC5
15	Predictive value of clinical and laboratory variables for vesicoureteral reflux in children. (17273861)	Soylu A.... KavukAsu S.	2007	CRP
16	Genetic control of VEGF and TGF-beta1 gene polymorphisms in childhood urinary tract infection and vesicoureteral reflux. (17597658)	Yim H.E.... Lee J.W.	2007	TGFB1, VEGFA
17	Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux. (17880289)	Iwaki H.... Yoshiki T.	2007	UPK3A
18	Association of transforming growth factor-beta1 gene polymorphism with familial vesicoureteral reflux. (17707032)	Kuroda S.... Puri P.	2007	TGFB1
19	Structural changes of the intravesical ureter in chil dren with vesicoureteral reflux-does ischemia have a role? (17070295)	Schwentner C.... Radmayr C.	2006	VEGFA
20	Urothelial differentiation in vesicoureteric reflux and other urological disorders of childhood: a comparative study. (16314030)	Garthwaite M.A.... Southgate J.	2006	UPK1A, UPK1B
21	Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux. (15942792)	Kalman S.... SAPylemezoA9lu O.	2005	ADM
22	Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. (15523493)	Kelly H.... Barton D.E.	2005	UPK3A
23	Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux. (15086490)	Lee-Chen G.J.... Lin C.Y.	2004	TGFB1, KLK1
24	Genetic polymorphism of the renin-angiotensin system on the development of primary vesicoureteral reflux. (14764974)	Yim H.E.... Kim S.K.	2004	ACE, AGTR2, AGTR1
25	No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux. (14713856)	Giltay J.C.... de Jong T.P.	2004	UPK3A
26	Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. (15200408)	Jiang S.... Sun T.T.	2004	UPK1A
27	Renin-angiotensin system polymorphisms in Taiwanese primary vesicoureteral reflux. (15045574)	Liu K.P.... Lee-Chen G.J.	2004	ACE, AGTR1, AGT
28	ACE gene polymorphism and renal scarring in children with urinary tract infection and vesicoureteric reflux: preliminary results (12728665)	Kowalewska-Pietrzak M.... Bodalski J.	2003	ACE
29	Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. (12187255)	Yoneda A.... Puri P.	2002	AGTR2
30	Molecular basis of vesicoureteral reflux (12244279)	Lama G.... Esposito Salsano M.	2002	PAX2
31	ACE gene polymorphism and renal scarring in primary vesicoureteric reflux. (12478352)	Haszon I.... Turi S.	2002	ACE
32	Susceptibility to vesicoureteral reflux in Japanese is linked to HLA-DR antigen. (11744483)	Kawauchi A.... Miki T.	2001	HLA-DRB1
33	Angiotensin-converting enzyme genotype distribution in familial vesicoureteral reflux. (11409168)	Yoneda A.... Puri P.	2001	ACE
34	Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. (10739767)	Feather S.A.... Goodship J.A.	2000	PAX2, VUR
35	Implications of certain genetic polymorphisms in scarring in vesicoureteric reflux: importance of ACE polymorphism. (10401028)	Ozen S.... Tuncbilek E.	1999	SERPINE1, ACE
36	Mutational analysis of the GDNF/RET-GDNFR-alpha signaling complex in a kindred with vesicoureteral reflux. (9600247)	Shefelbine S.E.... Gagel R.F.	1998	GFRA1
37	Absence of PAX2 gene mutations in patients with primary familial vesicoureteric reflux. (9598733)	Choi K.L.... Eccles M.R.	1998	PAX2
38	Followup study of renal function in children with ref lux nephropathy after resolution of vesicoureteral reflux. (9072628)	Konda R.... Orikasa S.	1997	AMBP
39	Elevated interleukin-8 levels in the urine of children with renal scarring and/or vesicoureteral reflux. (8558701)	Haraoka M.... Kumazawa J.	1996	IL6
40	Renal function in children with reflux nephropathy followed up more than 10 years after disappearance of vesicoureteral reflux: usefulness of alpha 1-microglobulin as a marker to predict the prognosis of these children (8969545)	Ota S.... Orikasa S.	1996	AMBP
41	Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. (7795640)	Sanyanusin P.... Eccles M.R.	1995	PAX2
42	Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux. (8154076)	Williams M.A.... Noe H.N.	1994	NAGLU
43	Urinary levels of N-acetyl-beta-D-glucosaminidase: a simple marker for predicting tubular damage in higher grades of vesicoureteric reflux. (8137853)	Miyakita H.... Puri P.	1994	NAGLU
44	Differential excretion of urinary proteins in children with vesicoureteric reflux and reflux nephropathy. (8142219)	Tomlinson P.A.... Chantler C.	1994	NAGLU
45	Value of urinary endothelin-1 in patients with primary vesicoureteral reflux. (8302406)	Komeyama T.... Sato S.	1993	EDN1
46	Urinary levels of renal tubular enzyme N-acetyl-beta-D-glucosaminidase in relation to grade of vesicoureteral reflux. (1861320)	Carr M.C.... Mandell J.	1991	NAGLU
47	Urinary Tamm-Horsfall protein excretion in patients with primary vesicoureteral reflux. (1915538)	Uto I.... Kambara T.	1991	UMOD

Genes related to vesicoureteral reflux according to GeneCards:

(show top 50)    (show all 57)

id	Symbol	Description	Score	GeneCards Section Context
1	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	11.1	Orthologs, Summaries, Publications
2	VUR5	Vesicoureteral reflux 5	11.1	Aliases & Descriptions
3	VUR4	Vesicoureteral reflux 4	11.1	Aliases & Descriptions
4	VUR6	Vesicoureteral reflux 6	11.1	Aliases & Descriptions
5	VUR	Vesicoureteral reflux	11.1	Publications, Aliases & Descriptions
6	UPK3A	uroplakin 3A	11.0	Publications
7	SOX17	SRY (sex determining region Y)-box 17	11.0
8	PAX2	paired box 2	11.0	Publications
9	AGTR2	angiotensin II receptor, type 2	11.0	Publications
10	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
11	UMOD	uromodulin	11.0	Publications
12	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
13	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
14	AGTR1	angiotensin II receptor, type 1	11.0	Publications
15	TIAF1	TGFB1-induced anti-apoptotic factor 1	11.0	Disorders
16	UPK1A	uroplakin 1A	11.0	Publications
17	UPK2	uroplakin 2	11.0
18	UPK1B	uroplakin 1B	11.0	Publications
19	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	11.0	Orthologs
20	ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	11.0	Orthologs
21	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
22	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	11.0	Disorders
23	TMEM173	transmembrane protein 173	11.0
24	AKAP2	A kinase (PRKA) anchor protein 2	11.0
25	INSRR	insulin receptor-related receptor	11.0
26	KLK1	kallikrein 1	11.0	Publications
27	FGFRL1	fibroblast growth factor receptor-like 1	11.0
28	PRUNE	prune homolog (Drosophila)	11.0
29	PALMD	palmdelphin	11.0
30	PALM	paralemmin	11.0
31	PCDH11Y	protocadherin 11 Y-linked	11.0	Publications
32	MEOX2	mesenchyme homeobox 2	11.0
33	UBTD2	ubiquitin domain containing 2	11.0	Disorders
34	HNF1B	HNF1 homeobox B	11.0	Publications
35	ADM	adrenomedullin	11.0	Publications
36	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
37	IFNGR1	interferon gamma receptor 1	11.0	Publications
38	ZCCHC14	zinc finger, CCHC domain containing 14	11.0
39	SCIN	scinderin	11.0
40	IL4R	interleukin 4 receptor	11.0	Publications
41	MYO18A	myosin XVIIIA	11.0
42	GFRA1	GDNF family receptor alpha 1	11.0	Publications
43	FBXW11	F-box and WD repeat domain containing 11	11.0
44	RET	ret proto-oncogene	11.0	Publications
45	EDN1	endothelin 1	11.0	Publications
46	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
47	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
48	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
49	TGFB1	transforming growth factor, beta 1	11.0	Publications
50	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to vesicoureteral reflux according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.6	AGTR1, AGTR2
2	Development_Slit-Robo signaling41	9.8	ROBO1, ROBO2, ROBO3, ROBO4
3	Renin-angiotensin system20	9.8	AGTR2, AGTR1, AGT, ACE, REN
4	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.6	IL4R, IL6, TGFB1
5	Cytoskeleton remodeling Slit-Robo signaling10	9.5	ROBO4, ROBO3, ROBO2, ROBO1
6	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.5	TGFB1, AGTR2, AGTR1, AGT, ACE, REN
7	Renin-Angiotensin Pathway36	9.0	TGFB1, AGTR2, AGTR1, AGT, ACE, IL6
8	THC Differentiation Pathway36	8.9	TNF, HLA-DRB1, IFNGR1, IL4R
9	JAK-STAT Pathway36	8.7	TGFB1, AGTR2, AGTR1, AGT, IFNGR1, IL8
10	Immune response IL-1 signaling pathway10	8.6	EDN1, TNF, IL8, IL6, SERPINE1
11	Immune response_IL-1 signaling pathway41	8.6	EDN1, TNF, IL8, IL6, SERPINE1
12	Malaria20	8.6	TGFB1, TNF, IL8, IL6
13	Chagas disease (American trypanosomiasis)20	8.2	TGFB1, ACE, TNF, IFNGR1, IL8, IL6
14	Cytokine-cytokine receptor interaction20	7.8	TGFB1, TNF, IFNGR1, IL8, IL6, IL4R
15	Rheumatoid arthritis20	7.6	TGFB1, TNF, HLA-DRB1, IL8, IL6, VEGFA

Compounds related to vesicoureteral reflux according to GeneDecks:

(show top 50)    (show all 149)

id	Compound	Score	Top Affiliating Genes
1	atenolol32 9 18 9	13.6	SERPINE1
2	aprotinin32 9 9	12.5	NAGLU, AMBP, AGT
3	n acetylcysteine32	10.2	BIRC5, NAGLU, AGT
4	captopril32 42 9 9	13.0	REN, AGT, ACE
5	sodium nitroprusside32	9.9	AGTR1, REN
6	saralasin32 42	10.9	ACE, REN, AGTR1, AGTR2, AGT
7	aliskiren32 9 9	11.9	ACE, AGTR1, AGT, REN
8	lacidipine32	9.7	ACE, REN, AGTR1, EDN1
9	eprosartan32 9 9	11.7	AGTR1, SERPINE1, REN, ACE, AGT
10	pd12331932	9.7	ACE, AGT, AGTR1, AGTR2
11	chymostatin32	9.6	AGTR1, ACE, REN, EDN1, AGT
12	benazepril32 9 9	11.6	REN, ACE, TGFB1, AGT, AGTR1
13	trandolapril32 9 9	11.6	ACE, AGTR1, EDN1, REN
14	irbesartan32 9 9	11.6	AGTR1, AGTR2, AGT, ACE, SERPINE1, REN
15	uric acid32 18	10.6	CRP, UMOD, NAGLU, SERPINE1, AMBP, HNF1B
16	telmisartan32 9 9	11.5	REN, ACE, AGT, AGTR1, AGTR2, CRP
17	lisinopril32 9 18 9	12.4	ACE, VEGFA, REN, AGT, AGTR1
18	cilazapril32 9 9	11.4	ACE, REN, EDN1, AGTR1
19	sodium32 18	10.4	ADM, REN, BIRC5, UMOD, AMBP, NAGLU
20	fosinopril32 9 9	11.3	CRP, SERPINE1, REN, AGTR1, ACE
21	hydrochlorothiazide32 34 9 18 9	13.2	REN, AGT, SERPINE1, CRP, AGTR1, ACE
22	enalapril32 9 9	11.2	REN, AMBP, AGTR2, AGTR1, AGT, EDN1
23	omapatrilat32	9.2	EDN1, REN, ACE, ADM
24	ulinastatin32	9.2	TNF, AMBP, IL8, IL6, NAGLU
25	quinapril32 9 9	11.1	AGTR1, ACE, CRP, SERPINE1, REN, EDN1
26	carvedilol32 34 9 9	12.1	ADM, EDN1, REN, VEGFA, ACE, AGTR1
27	ramipril32 9 9	11.0	TGFB1, AGTR1, ACE, CRP, SERPINE1, REN
28	verapamil32 34 9 18 9	13.0	AGTR1, ACE, EDN1, AMBP, NAGLU, TGFB1
29	valsartan32 42 9 9	12.0	REN, AGTR2, CRP, AGTR1, AGT, ACE
30	nifedipine32 9 9	11.0	TGFB1, AGTR1, EDN1, AGT, AMBP, REN
31	prostaglandin32	8.8	REN, AGTR2, ADM, AGTR1, AGT, TNF
32	candesartan32 9 9	10.8	AGTR1, REN, TGFB1, AGTR2, AGT, ACE
33	vegf32	8.7	CRP, REN, RET, TGFB1, ADM, AGTR1
34	ang ii32	8.7	AGTR1, AGT, EDN1, AGTR2, VEGFA, ACE
35	losartan32 34 9 9	11.4	NAGLU, CRP, ADM, REN, SERPINE1, AGTR1
36	perindopril32 34 9 9	11.4	AGTR1, REN, SERPINE1, NAGLU, VEGFA, CRP
37	sb 20358032 42	9.4	TNF, VEGFA, AGTR1, AGT, EDN1, CRP
38	8-isoprostane32	8.4	TNF, SERPINE1, IL6, IL8, CRP, EDN1
39	atorvastatin32 34 9 18 9	12.3	IL6, TNF, AGT, EDN1, CRP, VEGFA
40	troglitazone32 42 9 9	11.3	IL8, SERPINE1, BIRC5, UPK1B, UPK2, TGFB1
41	indomethacin32 9 9	10.1	EDN1, ADM, TGFB1, AGTR2, AGT, REN
42	cyclosporin a32 42	9.0	IL4R, TNF, NAGLU, EDN1, IL6, IL8
43	simvastatin32 34 42 9 18 9	12.9	SERPINE1, VEGFA, AGTR1, AGT, TNF, IL8
44	creatinine32	7.9	REN, SERPINE1, NAGLU, UMOD, IL6, AMBP
45	prostacyclin32	7.8	ADM, AGTR2, AGTR1, AGT, ACE, EDN1
46	ly29400232	7.7	IL6, RET, IL8, TNF, CRP, AGT
47	actinomycin d32	7.2	SERPINE1, ADM, BIRC5, VEGFA, TGFB1, AGTR1
48	nitric oxide32 9 18 9	10.1	ADM, AGTR2, AGTR1, AGT, ACE, EDN1
49	cycloheximide32	6.8	EDN1, AGTR1, TGFB1, ADM, SERPINE1, AGTR2
50	dexamethasone32 42 34 9 9	10.7	ADM, TGFB1, AGT, SERPINE1, VEGFA, BIRC5

Cellular components related to vesicoureteral reflux according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	7.3	ROBO1, AGTR2, AGTR1, TNF, HLA-DRB1, IFNGR1
2	extracellular region	GO:005576	7.0	CRP, EDN1, AGT, AGTR2, TGFB1, AMBP
3	extracellular space	GO:005615	5.7	REN, ADM, TGFB1, AGT, ACE, EDN1

Biological processes related to vesicoureteral reflux according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of metanephric glomerulus development	GO:072300	10.4	AGTR2, PAX2, RET
2	epithelial cell differentiation	GO:030855	10.4	UPK3A, UPK2, UPK1B, UPK1A
3	regulation of metanephros size	GO:035566	10.3	AGTR2, PAX2
4	positive regulation of branching involved in ureteric bud morphogenesis	GO:090190	10.2	TGFB1, AGTR2, AGT, PAX2
5	axon midline choice point recognition	GO:016199	10.2	ROBO3, ROBO2, ROBO1
6	positive regulation of NAD(P)H oxidase activity	GO:033864	10.2	AGTR1, AGT
7	positive regulation of cellular protein metabolic process	GO:032270	10.2	AGT, AGTR1, TGFB1
8	renin-angiotensin regulation of aldosterone production	GO:002018	10.2	AGTR1, AGT, REN
9	regulation of vasoconstriction	GO:019229	10.1	AGTR1, AGT, ACE, EDN1
10	negative regulation of negative chemotaxis	GO:050925	10.1	ROBO1, ROBO2
11	regulation of renal output by angiotensin	GO:002019	10.1	AGT, ACE
12	kidney development	GO:001822	9.7	REN, UPK3A, HNF1B, ACE, AGT, AGTR1
13	mononuclear cell proliferation	GO:032943	9.6	TGFB1, ACE
14	negative regulation of lipid storage	GO:010888	9.5	IL6, TNF, CRP
15	positive regulation of protein complex assembly	GO:031334	9.3	TGFB1, TNF, VEGFA
16	calcium-mediated signaling	GO:019722	9.2	AGTR1, EDN1, TNF, IL8
17	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, EDN1, TNF, VEGFA
18	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.0	VEGFA, IL6, TNF, TGFB1
19	angiogenesis	GO:001525	8.9	ROBO4, SOX17, IL8, MEOX2, VEGFA, SERPINE1
20	positive regulation of transcription, DNA-dependent	GO:045893	8.7	SOX17, TGFB1, AGTR2, AGT, TNF, HNF1B
21	response to hypoxia	GO:001666	8.5	ADM, TGFB1, EDN1, CRP, TNF, VEGFA
22	negative regulation of cell proliferation	GO:008285	8.3	ADM, TGFB1, AGT, TNF, IL8, IL6
23	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.2	SOX17, TGFB1, TMEM173, TNF, HNF1B, IL6

Molecular functions related to vesicoureteral reflux according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor binding	GO:031711	10.1	ACE, AGTR1
2	acetyltransferase activator activity	GO:010698	10.0	AGT, AGTR1
3	protein homodimerization activity	GO:042803	8.3	VEGFA, ROBO3, TGFB1, CRP, TMEM173, HNF1B