MCID: VSC005
MIFTS: 46

Vesicoureteral Reflux malady

Genetic diseases, Fetal diseases, Rare diseases categories

Aliases & Classifications for Vesicoureteral Reflux

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Vesicoureteral Reflux, Aliases & Descriptions:

Name: Vesicoureteral Reflux 9 10 11 43
 
Vesico-Ureteral Reflux 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases


External Ids:

Disease Ontology9 DOID:9620
MeSH33 D014718
ICD9CM27 593.7
NCIt38 C84467

Summaries for Vesicoureteral Reflux

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Wikipedia:63 Vesicoureteral reflux (VUR) is an abnormal backward movement of urine from the bladder into ureters or... more...

MalaCards based summary: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to vesicoureteral reflux 2 and hydronephrosis. An important gene associated with Vesicoureteral Reflux is ROBO2 (roundabout, axon guidance receptor, homolog 2 (Drosophila)), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Disease Ontology:9 A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.

Related Diseases for Vesicoureteral Reflux

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Diseases in the Vesicoureteral Reflux family:

Vesicoureteral Reflux 2 Vesicoureteral Reflux 4
Vesicoureteral Reflux 8 Vesicoureteral Reflux 3
Vesicoureteral Reflux 7 Vesicoureteral Reflux 5
Vesicoureteral Reflux 6 Vesicoureteral Reflux 1
Familial Vesicoureteral Reflux

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux 231.6ROBO2
2hydronephrosis31.3NAGLU, AGTR2
3pyelonephritis31.1UMOD, NAGLU
4urinary tract obstruction30.5NAGLU, UMOD
5chronic pyelonephritis30.5NAGLU, UMOD
6cystitis30.4NAGLU, UMOD
7nephrocalcinosis30.2UMOD, NAGLU
8focal segmental glomerulosclerosis30.1AGTR1, PAX2, NAGLU
9kidney disease29.8PAX2, UMOD, AGTR1
10proteinuria29.2NAGLU, PAX2, UMOD, AGTR2, AGTR1
11urethritis10.7
12familial vesicoureteral reflux10.7
13neurogenic bladder10.7
14posterior urethral valves10.7
15acute pyelonephritis10.6
16ureterocele10.6
17vesicoureteral reflux 310.5
18papillorenal syndrome10.5
19ureteral obstruction10.5
20polyhydramnios10.5
21vesicoureteral reflux 410.5
22vesicoureteral reflux 510.5
23vesicoureteral reflux 610.5
24vesicoureteral reflux 110.5
25epispadias10.5
26vesicoureteral reflux 810.4
27williams-beuren syndrome10.4
28trichorhinophalangeal syndrome, type ii10.4
29urofacial syndrome 110.4
30vesicoureteral reflux 710.4
31townes-brocks syndrome10.4
32koolen-de vries syndrome10.4
33hand-foot-uterus syndrome10.4
34hinman syndrome10.4
35hydrocephalus10.3
36detrusor sphincter dyssynergia10.3
37transient pseudohypoaldosteronism10.3
38urofacial syndrome 210.3
39congenital anomalies of kidney and urinary tract10.3
40alstrom syndrome10.3
41mowat-wilson syndrome10.3
42baller-gerold syndrome10.3
43kleefstra syndrome10.3
44velocardiofacial syndrome10.3
45melnick-needles syndrome10.3
46caudal regression syndrome10.3
47eagle-barrett syndrome10.3
48hypoparathyroidism, sensorineural deafness, and renal dysplasia10.3
49star syndrome10.3
50cornelia de lange syndrome10.3

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to vesicoureteral reflux

Symptoms for Vesicoureteral Reflux

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Drugs & Therapeutics for Vesicoureteral Reflux

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Drug clinical trials:

Search ClinicalTrials for Vesicoureteral Reflux

Search NIH Clinical Center for Vesicoureteral Reflux

Genetic Tests for Vesicoureteral Reflux

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Anatomical Context for Vesicoureteral Reflux

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MalaCards organs/tissues related to Vesicoureteral Reflux:

31
Kidney, Testes, Spinal cord, Neutrophil

Animal Models for Vesicoureteral Reflux or affiliated genes

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MGI Mouse Phenotypes related to Vesicoureteral Reflux:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0NAGLU, PAX2, ROBO2, AGTR2, AGTR1
2MP:00053767.9AGTR1, AGTR2, ROBO2, UMOD, UPK3A
3MP:00107687.5SOX17, NAGLU, PAX2, ROBO2, AGTR2, AGTR1
4MP:00053787.5SOX17, NAGLU, UMOD, AGTR2, AGTR1
5MP:00053676.8AGTR1, AGTR2, ROBO2, UMOD, UPK3A, PAX2

Publications for Vesicoureteral Reflux

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Articles related to Vesicoureteral Reflux:

(show top 50)    (show all 633)
idTitleAuthorsYear
1
The use of polyacrylate-polyalcohol copolymer hydrogel in the endoscopic treatment of primary vesicoureteral reflux in children. (25746713)
2015
2
Antimicrobial prophylaxis for children with vesicoureteral reflux. (25207774)
2014
3
Ureteral triplication and contralateral duplication with vesicoureteral reflux. (25603691)
2014
4
Antimicrobial prophylaxis for children with vesicoureteral reflux. (25207772)
2014
5
Prospective study using a new bulking agent for the treatment of vesicoureteral reflux: polyacrylamide hydrogel. (23538241)
2013
6
Carbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux model. (24005825)
2013
7
Practice patterns among pediatric urologists in the use of DefluxAr for vesicoureteral reflux: a survey. (23466044)
2013
8
Evaluation of children with urinary tract infection - Impact of the 2011 AAP guidelines on the diagnosis of vesicoureteral reflux using a historical series. (24063867)
2013
9
Acute and delayed vesicoureteral obstruction after endoscopic treatment of primary vesicoureteral reflux with dextranomer/hyaluronic acid copolymer: why and how to manage. (23507288)
2013
10
The RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux. (23753091)
2013
11
Predictive Risk Factors in Childhood Urinary Tract Infection, Vesicoureteral Reflux, and Renal Scarring Management. (24366998)
2013
12
Relationship among bacterial virulence, bladder dysfunction, vesicoureteral reflux and patterns of urinary tract infection in children. (22595065)
2012
13
Renal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux. (22080623)
2012
14
Association of nocturnal enuresis with vesicoureteral reflux and renal cortical damage. (23573464)
2012
15
Presence of dextranomer-hyaluronic acid (DxHA) mound on postoperative ultrasound does not predict resolution of vesicoureteral reflux. (21672652)
2011
16
Vesicoureteral reflux in children: a phantom study of microwave heating and radiometric thermometry of pediatric bladder. (21900069)
2011
17
Surgical Reimplantation for the Correction of Vesicoureteral Reflux following Failed Endoscopic Injection. (21274435)
2011
18
New noninvasive methods to diagnose vesicoureteral reflux. (21519276)
2011
19
Can we rely on the presence of dextranomer-hyaluronic acid copolymer mounds on ultrasound to predict vesicoureteral reflux resolution after injection therapy? (21555031)
2011
20
Predictors of surgical outcome in children with vesicoureteral reflux associated with paraureteral diverticula. (20189227)
2010
21
Vesicoureteral reflux in children with urinary tract infection: comparison of diagnostic accuracy of renal US criteria. (20501726)
2010
22
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
23
Is there a learning curve for subureteric injection of dextranomer/hyaluronic acid in the treatment of vesicoureteral reflux? (19740702)
2010
24
The Swedish reflux trial in children: II. Vesicoureteral reflux outcome. (20488469)
2010
25
Re: Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux. Editorial comment. (20650498)
2010
26
Cross-sectional evaluation of parental decision making factors for vesicoureteral reflux management in children. (20728107)
2010
27
Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux? (19438835)
2009
28
Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection. (19968584)
2009
29
Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity in children with vesicoureteral reflux. (19408836)
2009
30
Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. (18604293)
2008
31
Microalbuminuria in children with vesicoureteral reflux. (18661415)
2008
32
A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. (18197425)
2008
33
Vesicoureteral reflux. (18322164)
2008
34
Mini-ureteroneocystostomy: a safe and effective outpatient treatment for unilateral vesicoureteral reflux. (18708210)
2008
35
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators. (19018047)
2008
36
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. (17357069)
2007
37
Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. (18074194)
2007
38
Pediatric vesicoureteral reflux: treatment patterns and outcomes. (17667907)
2007
39
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
40
Predictive value of clinical factors for successful endoscopic correction of primary vesicoureteral reflux grades III-IV. (18947678)
2006
41
Loss of interstitial cells of Cajal and gap junction protein connexin 43 at the vesicoureteral junction in children with vesicoureteral reflux. (16217373)
2005
42
Urinary tract infection and vesicoureteral reflux in saudi children. (18209408)
2002
43
Management of vesicoureteral reflux secondary to neurogenic bladder. (9799381)
1998
44
An alternative ureteroileal reimplantation used in augmentation cystoplasty for neurogenic bladder with bilateral vesicoureteral reflux. (9751368)
1998
45
Renal tubular acidosis in children with vesicoureteral reflux. (8648800)
1996
46
Incidence of vesicoureteral reflux in children with unilateral renal agenesis. (7869521)
1995
47
Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux. (8154076)
1994
48
Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infection? (8284391)
1994
49
Initiation of vesicoureteral reflux after heminephrectomy for ureterocele. (2929061)
1989
50
EXPERIMENTAL BLADDER NECK OBSTRUCTION. I. INCIDENCE OF VESICOURETERAL REFLUX, UPPER TRACT DILATION, AND URINARY INFECTION IN RABBITS. (14078534)
1963

Variations for Vesicoureteral Reflux

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Expression for genes affiliated with Vesicoureteral Reflux

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Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for genes affiliated with Vesicoureteral Reflux

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Pathways related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5AGTR1, AGTR2

Compounds for genes affiliated with Vesicoureteral Reflux

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Compounds related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1angiotensin iii289.9AGTR2, AGTR1
2angiotensin i289.9AGTR2, AGTR1
3etoperidone439.9AGTR2, AGTR1
4cgp42112a439.9AGTR1, AGTR2
5angiotensin ii28 2410.9AGTR2, AGTR1
6saralasin439.9AGTR2, AGTR1
7pd12331943 2810.9AGTR1, AGTR2
8valsartan43 59 28 1212.8AGTR1, AGTR2
9telmisartan43 28 1211.8AGTR2, AGTR1
10irbesartan43 28 49 1212.8AGTR2, AGTR1
11candesartan43 49 28 1212.8AGTR1, AGTR2
12spironolactone43 59 28 49 1213.8AGTR1, AGTR2
13perindopril43 49 1211.8NAGLU, AGTR1
14ang ii439.8AGTR2, AGTR1
15captopril43 59 49 28 1213.8AGTR2, AGTR1
16furosemide43 59 28 49 24 1214.7AGTR1, NAGLU
17thromboxane a243 2410.6AGTR1, NAGLU
18dithiothreitol439.5AGTR1, AGTR2
19vitamin-e439.5NAGLU, AGTR1
20calcium oxalate439.5NAGLU, UMOD
21oxalate439.5UMOD, NAGLU
22verapamil43 28 49 24 1213.4AGTR1, NAGLU
23catecholamine439.4AGTR1, AGTR2
24enalapril43 49 1211.4AGTR1, AGTR2, NAGLU
25losartan43 49 28 1212.4NAGLU, AGTR2, AGTR1
26colchicine43 59 2 28 1213.2UMOD, NAGLU
27cyclosporin a43 28 5911.2AGTR1, AGTR2, NAGLU
28nadph43 2410.2AGTR1, AGTR2, NAGLU
29superoxide43 2410.2NAGLU, AGTR2, AGTR1
30uric acid43 2410.0AGTR1, UMOD, NAGLU
31potassium43 24 1210.9NAGLU, UMOD, AGTR1
32sulfate43 249.8UMOD, NAGLU
33heparin43 28 24 1211.8AGTR1, UMOD, NAGLU
34sodium43 249.5NAGLU, UMOD, AGTR2, AGTR1
35creatinine438.5AGTR1, AGTR2, UMOD, NAGLU

GO Terms for genes affiliated with Vesicoureteral Reflux

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Cellular components related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.4ROBO2, UMOD, UPK3A, NAGLU

Biological processes related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell growthGO:00303089.6AGTR2, SOX17
2angiotensin-activated signaling pathwayGO:00381669.6AGTR2, AGTR1
3regulation of metanephros sizeGO:00355669.6AGTR2, PAX2
4positive regulation of metanephric glomerulus developmentGO:00723009.6AGTR2, PAX2
5renin-angiotensin regulation of aldosterone productionGO:00020189.6AGTR2, AGTR1
6positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.4AGTR2, PAX2
7kidney developmentGO:00018229.2AGTR1, UPK3A
8metanephric distal convoluted tubule developmentGO:00722219.2PAX2, UMOD
9positive regulation of transcription, DNA-templatedGO:00458938.9SOX17, PAX2, AGTR2

Molecular functions related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00049459.5AGTR1, AGTR2

Products for genes affiliated with Vesicoureteral Reflux

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Sources for Vesicoureteral Reflux

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet