MCID: VSC005
MIFTS: 51

Vesicoureteral Reflux malady

Genetic diseases, Fetal diseases, Rare diseases categories
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Summaries for Vesicoureteral Reflux

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Wikipedia:65 Vesicoureteral reflux (VUR) is an abnormal backward movement of urine from the bladder into ureters or... more...

MalaCards based summary: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to vesicoureteral reflux 2 and pyelonephritis. An important gene associated with Vesicoureteral Reflux is VUR (Vesicoureteral reflux). The compounds calcium oxalate and oxalate have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord, and related mouse phenotypes are cardiovascular system and mortality/aging.

Descriptions from OMIM:46 614674,314550,610878,193000

Aliases & Classifications for Vesicoureteral Reflux

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Vesicoureteral Reflux, Aliases & Descriptions:

Name: Vesicoureteral Reflux 8 9 46 10 44
 
Vesico-Ureteral Reflux 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases


External Ids:

Disease Ontology8 DOID:9620
NCIt39 C84467
ICD9CM27 593.7
MeSH34 D014718

Related Diseases for Vesicoureteral Reflux

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Diseases in the Vesicoureteral Reflux 8 family:

vesicoureteral reflux Vesicoureteral Reflux 2
Vesicoureteral Reflux 1 Vesicoureteral Reflux 4
Vesicoureteral Reflux 3 Vesicoureteral Reflux 7
Vesicoureteral Reflux 5 Vesicoureteral Reflux 6

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux 231.4ROBO2
2pyelonephritis31.2UMOD, NAGLU
3hydronephrosis31.2NAGLU, AGTR2
4urinary tract obstruction30.6NAGLU, UMOD
5chronic pyelonephritis30.6UMOD, NAGLU
6renal agenesis30.5AGTR2, PAX2
7cystitis30.3NAGLU, UMOD
8nephrocalcinosis30.3NAGLU, UMOD
9focal segmental glomerulosclerosis30.1NAGLU, PAX2
10proteinuria29.5NAGLU, UMOD, PAX2, AGTR2
11urethritis10.7
12neurogenic bladder10.7
13posterior urethral valves10.7
14acute pyelonephritis10.6
15ureterocele10.6
16ureteral obstruction10.5
17polyhydramnios10.5
18hypertension10.4
19renal coloboma syndrome10.4
20vesicoureteral reflux 110.4
21vesicoureteral reflux 810.4
22epispadias10.4
23vesicoureteral reflux 410.4
24vesicoureteral reflux 310.4
25vesicoureteral reflux 510.4
26vesicoureteral reflux 610.4
27hydrocephalus10.3
28detrusor sphincter dyssynergia10.3
29hirschsprung's disease10.3
30transient pseudohypoaldosteronism10.3
31trigonitis10.3
32bladder diverticulum10.3
33urethral obstruction10.3
34urofacial syndrome 110.3
35vesicoureteral reflux 710.3
36blindness10.3
37exstrophy-epispadias complex10.3
38renal dysplasia10.3
39renal hypoplasia10.3
40hinman syndrome10.3
41arthritis10.1
42end stage renal failure10.1
43fanconi's anemia10.1
44pseudohypoaldosteronism10.1
45renal tubular acidosis10.1
46spina bifida10.1
47perinephritis10.1
48pfeiffer syndrome10.1
49thrombocytopenia-absent radius syndrome10.1
50williams-beuren syndrome10.1

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to vesicoureteral reflux

Symptoms for Vesicoureteral Reflux

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Clinical features from OMIM:

614674,314550,610878,193000

Drugs & Therapeutics for Vesicoureteral Reflux

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Drug clinical trials:

Search ClinicalTrials for Vesicoureteral Reflux

Search NIH Clinical Center for Vesicoureteral Reflux

Genetic Tests for Vesicoureteral Reflux

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Anatomical Context for Vesicoureteral Reflux

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MalaCards organs/tissues related to Vesicoureteral Reflux:

32
Kidney, Testes, Spinal cord, Neutrophil

Animal Models for Vesicoureteral Reflux or affiliated genes

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MGI Mouse Phenotypes related to Vesicoureteral Reflux:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8NAGLU, PAX2, ROBO2, AGTR2
2MP:00107687.7SOX17, NAGLU, PAX2, ROBO2, AGTR2
3MP:00053677.1NAGLU, PAX2, UPK3A, UMOD, ROBO2, AGTR2

Publications for Vesicoureteral Reflux

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Articles related to Vesicoureteral Reflux:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Antimicrobial prophylaxis for children with vesicoureteral reflux. (25207774)
2014
2
Antimicrobial prophylaxis for children with vesicoureteral reflux. (25207772)
2014
3
Prospective study using a new bulking agent for the treatment of vesicoureteral reflux: polyacrylamide hydrogel. (23538241)
2013
4
Carbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux model. (24005825)
2013
5
Practice patterns among pediatric urologists in the use of DefluxAr for vesicoureteral reflux: a survey. (23466044)
2013
6
Evaluation of children with urinary tract infection - Impact of the 2011 AAP guidelines on the diagnosis of vesicoureteral reflux using a historical series. (24063867)
2013
7
Acute and delayed vesicoureteral obstruction after endoscopic treatment of primary vesicoureteral reflux with dextranomer/hyaluronic acid copolymer: why and how to manage. (23507288)
2013
8
The RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux. (23753091)
2013
9
Predictive Risk Factors in Childhood Urinary Tract Infection, Vesicoureteral Reflux, and Renal Scarring Management. (24366998)
2013
10
Relationship among bacterial virulence, bladder dysfunction, vesicoureteral reflux and patterns of urinary tract infection in children. (22595065)
2012
11
Renal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux. (22080623)
2012
12
Association of nocturnal enuresis with vesicoureteral reflux and renal cortical damage. (23573464)
2012
13
Presence of dextranomer-hyaluronic acid (DxHA) mound on postoperative ultrasound does not predict resolution of vesicoureteral reflux. (21672652)
2011
14
Vesicoureteral reflux in children: a phantom study of microwave heating and radiometric thermometry of pediatric bladder. (21900069)
2011
15
Surgical Reimplantation for the Correction of Vesicoureteral Reflux following Failed Endoscopic Injection. (21274435)
2011
16
New noninvasive methods to diagnose vesicoureteral reflux. (21519276)
2011
17
Can we rely on the presence of dextranomer-hyaluronic acid copolymer mounds on ultrasound to predict vesicoureteral reflux resolution after injection therapy? (21555031)
2011
18
Predictors of surgical outcome in children with vesicoureteral reflux associated with paraureteral diverticula. (20189227)
2010
19
Vesicoureteral reflux in children with urinary tract infection: comparison of diagnostic accuracy of renal US criteria. (20501726)
2010
20
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
21
Is there a learning curve for subureteric injection of dextranomer/hyaluronic acid in the treatment of vesicoureteral reflux? (19740702)
2010
22
The Swedish reflux trial in children: II. Vesicoureteral reflux outcome. (20488469)
2010
23
Re: Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux. Editorial comment. (20650498)
2010
24
Cross-sectional evaluation of parental decision making factors for vesicoureteral reflux management in children. (20728107)
2010
25
The value of estimation of distal ureteral dilatation in primary vesicoureteral reflux. (20495700)
2010
26
Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux? (19438835)
2009
27
Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection. (19968584)
2009
28
Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity in children with vesicoureteral reflux. (19408836)
2009
29
Validation of a prognostic calculator for prediction of early vesicoureteral reflux resolution in children. (19539324)
2009
30
Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. (18604293)
2008
31
Microalbuminuria in children with vesicoureteral reflux. (18661415)
2008
32
A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. (18197425)
2008
33
Vesicoureteral reflux. (18322164)
2008
34
Mini-ureteroneocystostomy: a safe and effective outpatient treatment for unilateral vesicoureteral reflux. (18708210)
2008
35
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators. (19018047)
2008
36
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. (17357069)
2007
37
Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. (18074194)
2007
38
Pediatric vesicoureteral reflux: treatment patterns and outcomes. (17667907)
2007
39
Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux. (16967282)
2007
40
Predictive value of clinical factors for successful endoscopic correction of primary vesicoureteral reflux grades III-IV. (18947678)
2006
41
Loss of interstitial cells of Cajal and gap junction protein connexin 43 at the vesicoureteral junction in children with vesicoureteral reflux. (16217373)
2005
42
Urinary tract infection and vesicoureteral reflux in saudi children. (18209408)
2002
43
Management of vesicoureteral reflux secondary to neurogenic bladder. (9799381)
1998
44
An alternative ureteroileal reimplantation used in augmentation cystoplasty for neurogenic bladder with bilateral vesicoureteral reflux. (9751368)
1998
45
Renal tubular acidosis in children with vesicoureteral reflux. (8648800)
1996
46
Incidence of vesicoureteral reflux in children with unilateral renal agenesis. (7869521)
1995
47
Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux. (8154076)
1994
48
Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infection? (8284391)
1994
49
Initiation of vesicoureteral reflux after heminephrectomy for ureterocele. (2929061)
1989
50
EXPERIMENTAL BLADDER NECK OBSTRUCTION. I. INCIDENCE OF VESICOURETERAL REFLUX, UPPER TRACT DILATION, AND URINARY INFECTION IN RABBITS. (14078534)
1963

Variations for Vesicoureteral Reflux

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Expression for genes affiliated with Vesicoureteral Reflux

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Expression patterns in normal tissues for genes affiliated with Vesicoureteral Reflux

Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for genes affiliated with Vesicoureteral Reflux

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Compounds for genes affiliated with Vesicoureteral Reflux

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Compounds related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1calcium oxalate449.6UMOD, NAGLU
2oxalate449.6UMOD, NAGLU
3enalapril44 50 1111.6AGTR2, NAGLU
4losartan44 50 28 1112.5NAGLU, AGTR2
5colchicine44 61 2 28 1113.4UMOD, NAGLU
6uric acid44 2410.4UMOD, NAGLU
7sulfate44 2410.3NAGLU, UMOD
8citrate449.3UMOD, NAGLU
9urea44 24 1111.2UMOD, NAGLU
10sialic acid449.0UMOD, NAGLU
11sodium44 2410.0NAGLU, UMOD, AGTR2
12creatinine449.0AGTR2, UMOD, NAGLU

GO Terms for genes affiliated with Vesicoureteral Reflux

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Cellular components related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.5ROBO2, UMOD, UPK3A, NAGLU

Biological processes related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell growthGO:0303089.5AGTR2, SOX17
2regulation of metanephros sizeGO:0355669.2AGTR2, PAX2
3positive regulation of metanephric glomerulus developmentGO:0723009.2AGTR2, PAX2
4metanephric distal convoluted tubule developmentGO:0722219.1UMOD, PAX2
5positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0PAX2, AGTR2
6positive regulation of transcription, DNA-templatedGO:0458938.4AGTR2, PAX2, SOX17

Products for genes affiliated with Vesicoureteral Reflux

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Sources for Vesicoureteral Reflux

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet