MCID: VSC005
MIFTS: 51

Vesicoureteral Reflux malady

Summaries for Vesicoureteral Reflux

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Vesicoureteral reflux (VUR) is an abnormal movement of urine from the bladder into ureters or kidneys.... more...

MalaCards: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to hydronephrosis and ureteral obstruction. An important gene associated with Vesicoureteral Reflux is VUR (Vesicoureteral reflux), and among its related pathways are Renin-angiotensin system and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and t cells, and related mouse phenotype renal/urinary system.

Description from OMIM:47 314550,193000,614674,610878

Aliases & Classifications for Vesicoureteral Reflux

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

vesicoureteral reflux 8 9 47 10 45
vesico-ureteral reflux 8 61


External Ids:

Disease Ontology8 DOID:9620
MeSH35 D014718
ICD9CM27 593.7
NCIt40 C84467

Related Diseases for Vesicoureteral Reflux

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the vesicoureteral reflux 2 family:

vesicoureteral reflux vesicoureteral reflux 1
vesicoureteral reflux 4 vesicoureteral reflux 3
vesicoureteral reflux 7 vesicoureteral reflux 5
vesicoureteral reflux 6

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1hydronephrosis30.9AGTR2, PLEKHF1, NAGLU
2ureteral obstruction30.7AMBP, AGTR1
3urinary tract obstruction30.6NAGLU, AMBP, UMOD
4renal agenesis30.4AGTR2, PAX2
5focal segmental glomerulosclerosis30.1PAX2, AGTR1, NAGLU
6vesicoureteral reflux 210.7
7neurogenic bladder10.7
8posterior valve urethra10.7
9posterior urethral valve10.7
10posterior urethral valves10.6
11acute pyelonephritis10.6
12ureterocele10.5
13vesicoureteral reflux 110.5
14vesicoureteral reflux 310.5
15polyhydramnios10.5
16renal coloboma syndrome10.5
17epispadias10.4
18vesicoureteral reflux 410.3
19vesicoureteral reflux 510.3
20pseudohypoaldosteronism10.3
21detrusor sphincter dyssynergia10.3
22ureteral disease10.3
23vascular malformation multi-gene panels10.3
24transient pseudohypoaldosteronism10.3
25urethral syndrome10.3
26n syndrome10.3
27bladder diverticulum10.3
28urethral obstruction10.3
29pediatric hypertension10.3
30urofacial syndrome 110.3
31vesicoureteral reflux 710.3
32vesicoureteral reflux 610.3
33exstrophy-epispadias complex10.3
34renal dysplasia10.3
35renal hypoplasia10.3
36hinman's syndrome10.3
37thrombocytopenia-absent radius syndrome10.1
38klippel-trenaunay syndrome10.1
39bacteriuria10.1
40williams-beuren syndrome10.1
41cutis laxa10.1
42fanconi's anemia10.1
43alstrom syndrome10.1
44trichorhinophalangeal syndrome type ii10.1
45coloboma10.1
46digeorge syndrome10.1
47wolf-hirschhorn syndrome10.1
48bladder neck obstruction10.1
49microcephaly10.1
50matthew-wood syndrome10.1

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to vesicoureteral reflux

Clinical Features for Vesicoureteral Reflux

Sources:
47OMIM
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Clinical features from OMIM:

314550,193000,614674,610878

Drugs & Therapeutics for Vesicoureteral Reflux

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vesicoureteral Reflux

Drug clinical trials:

Search ClinicalTrials for Vesicoureteral Reflux

Search NIH Clinical Center for Vesicoureteral Reflux

Search CenterWatch for Vesicoureteral Reflux

Genetic Tests for Vesicoureteral Reflux

Anatomical Context for Vesicoureteral Reflux

Sources:
33MalaCards
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MalaCards organs/tissues related to Vesicoureteral Reflux:

33
Spinal cord, Kidney, T cells, B cells

Animal Models for Vesicoureteral Reflux or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Vesicoureteral Reflux:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.8PAX2, UPK2, UPK3A, AGTR2, AGTR1, AGT

Publications for Vesicoureteral Reflux

Sources:
51PubMed
See all sources

Articles related to Vesicoureteral Reflux:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
New Contralateral Vesicoureteral Reflux-Is it Double Trouble? (24231842)
2014
2
Presence of vesicoureteral reflux in the graft kidney does not adversely affect long-term graft outcome in kidney transplant recipients. (24157018)
2013
3
Clinical value of persistent but downgraded vesicoureteral reflux after dextranomer/hyaluronic acid injection in children. (23853490)
2013
4
A comparison of calcium hydroxyapatite and dextranomer/hyaluronic Acid for the endoscopic treatment of vesicoureteral reflux. (24235969)
2013
5
Childhood vesicoureteral reflux studies: registries and repositories sources and nosology. (23044377)
2013
6
Upregulation of tissue and urinary uroplakin mRNA in patients with vesicoureteral reflux. (24033750)
2013
7
Vesicoureteral reflux: current trends in diagnosis, screening, and treatment. (22264440)
2012
8
Computer-Enhanced Visual Learning Method to Teach Endoscopic Correction of Vesicoureteral Reflux: An Invitation to Residency Training Programs to Utilize the CEVL Method. (22272196)
2012
9
Asymptomatic chronic partial obstruction of a normal ureter following dextranomer/hyaluronic acid copolymer (DefluxAr) injection for grade I vesicoureteral reflux. (22209086)
2012
10
Quality of life in children with vesicoureteral reflux. (21959769)
2012
11
Endoscopic treatment of primary vesicoureteral reflux. (22455416)
2012
12
Familial vesicoureteral reflux and reflux related morbidity in relatives of index patients with high grade vesicoureteral reflux. (22906681)
2012
13
Clinical evolution of vesicoureteral reflux following endoscopic puncture in children with duplex system ureteroceles. (21862045)
2011
14
Predictors of surgical outcome in children with vesicoureteral reflux associated with paraureteral diverticula. (20189227)
2010
15
Ultrasound detection of vesicoureteral reflux in children. (20488482)
2010
16
Re: Outcome of antibiotic prophylaxis discontinuation in patients with persistent vesicoureteral reflux. Editorial comment. (20650502)
2010
17
Surgery Illustrated - Surgical Atlas Endoscopic treatment of vesicoureteral reflux. (20500570)
2010
18
Endoscopic Subureteral Injection for the Treatment of Vesicoureteral Reflux in Children: Polydimethylsiloxane (Macroplastique(R)) versus Dextranomer/Hyaluronic Acid Copolymer (Deflux(R)). (20414426)
2010
19
Urodynamic and histological changes in a sterile rabbit vesicoureteral reflux model. (20808680)
2010
20
Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity in children with vesicoureteral reflux. (19408836)
2009
21
Investigation of histopathologic changes in the ureter walls in vesicoureteral reflux. (19361644)
2009
22
Antibiotic prophylaxis in vesicoureteral reflux: A paradigm shift. (19468452)
2009
23
Importance of methodology on (99m)technetium dimercapto-succinic acid scintigraphic image quality: imaging pilot study for RIVUR (Randomized Intervention for Children With Vesicoureteral Reflux) multicenter investigation. (19450818)
2009
24
Transvesicoscopic Cohen ureteric reimplantation for vesicoureteral reflux in children: a single-centre 5-year experience. (19428305)
2009
25
Renin-angiotensin system polymorphisms: a risk factor for progression to end-stage renal disease in vesicoureteral reflux patients. (19288324)
2009
26
A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. (18197425)
2008
27
Vesicoureteral reflux. (18322164)
2008
28
Does the Deflux procedure reduce the incidence of urinary tract infections in children with vesicoureteral reflux? (18349859)
2008
29
Unilateral vesicoureteral reflux and history of contralateral vesicoureteral reflux warranting routine bilateral endoscopic correction. (18710733)
2008
30
Correlation of prenatal and postnatal ultrasound findings with the incidence of vesicoureteral reflux in children with fetal renal pelvic dilatation. (18718617)
2008
31
Adding renal scan data improves the accuracy of a computational model to predict vesicoureteral reflux resolution. (18715584)
2008
32
Postoperative cystography and endoscopic treatment of low-grade vesicoureteral reflux. (18503385)
2008
33
Interactions of constipation, dysfunctional elimination syndrome, and vesicoureteral reflux. (18604297)
2008
34
A new age in the management of vesicoureteral reflux? Infection rates after open surgery versus dextranomer injection. (18423755)
2008
35
Role of the Teflon deposit in the recurrence of vesicoureteral reflux. (18197421)
2008
36
Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. (18490378)
2008
37
Robotic-assisted laparoscopic management of vesicoureteral reflux. (18682821)
2008
38
Treatment of vesicoureteral reflux after puberty. (19266103)
2008
39
Pediatric vesicoureteral reflux: treatment patterns and outcomes. (17667907)
2007
40
New contralateral vesicoureteral reflux after endoscopic correction of unilateral reflux--is routine contralateral injection indicated at initial treatment? (17707017)
2007
41
The current evidence based medical management of vesicoureteral reflux: The Sickkids protocol. (19718297)
2007
42
Treatment of vesicoureteral reflux in children using stabilized non-animal hyaluronic acid/dextranomer gel (NASHA/DX): a long-term observational study. (18947708)
2007
43
Klippel-trenaunay-Weber syndrome with hydronephrosis and vesicoureteral reflux: an unusual association. (12026213)
2002
44
Management of vesicoureteral reflux secondary to neurogenic bladder. (9799381)
1998
45
Endoscopic correction of vesicoureteral reflux secondary to posterior urethral valves. (8683759)
1996
46
Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. (7795640)
1995
47
Endoscopic correction of vesicoureteral reflux in patients with neurogenic bladder dysfunction. (8775034)
1995
48
Vesicoureteral reflux in women with primary bladder diverticulum. (3925167)
1985
49
Unilateral vesicoureteral reflux and unilateral nonfunctioning kidney associated with posterior urethral valves--a syndrome? (6684182)
1983
50
URETEROCELE WITH ASSOCIATED VESICOURETERAL REFLUX. (14213533)
1964

Genetic Variations for Vesicoureteral Reflux

Expression for genes affiliated with Vesicoureteral Reflux

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vesicoureteral Reflux

Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for genes affiliated with Vesicoureteral Reflux

Sources:
30KEGG, 54Reactome, 50PharmGKB, 38NCBI BioSystems Database
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Pathways related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3AGT, AGTR1, AGTR2
2
Hide members
10.3AGT, AGTR1, AGTR2

Compounds for genes affiliated with Vesicoureteral Reflux

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1angiotensin iii2910.8AGTR2, AGTR1
2angiotensin i2910.8AGTR2, AGTR1
3etoperidone4510.8AGTR2, AGTR1
4Tasosartan1110.7AGTR2, AGTR1
5cgp42112a4510.7AGT, AGTR1, AGTR2
6saralasin4510.7AGTR2, AGTR1, AGT
7pd12331945 2911.7AGT, AGTR1, AGTR2
8cv 119744510.7AGTR1, AGT
9calcium oxalate4510.7AMBP, UMOD, NAGLU
1099mtc-dmsa4510.7AMBP, NAGLU
11inulin4510.7NAGLU, AGT, AMBP
12valsartan45 60 29 1113.7AGT, AGTR1, AGTR2
13amikacin4510.7AMBP, NAGLU
14telmisartan45 29 1112.7AGTR2, AGTR1, AGT
15perindopril45 50 1112.7AGTR1, AGT, NAGLU
16irbesartan45 29 50 1113.7AGT, AGTR1, AGTR2
17aliskiren45 1111.7AGT, AGTR1
18candesartan45 29 1112.7AGTR2, AGTR1, AGT
19angiotensin ii29 2411.7AGTR2, AGTR1
20losartan45 50 29 1113.7NAGLU, AGT, AGTR1, AGTR2
21dmsa4510.7AMBP, NAGLU
22captopril45 29 50 60 1114.7AGTR2, AGTR1, AGT
23ang ii4510.7AGTR2, AGTR1, AGT
24uric acid45 2411.7AMBP, UMOD, AGTR1, NAGLU
25benazepril45 1111.6AGT, AGTR1
26aprotinin45 1111.6KLK1, AMBP, AGT, NAGLU
27eprosartan45 29 1112.6AGT, AGTR1
28enalapril45 50 1112.6NAGLU, AGT, AGTR1, AGTR2, AMBP
29nifedipine45 50 29 1113.6NAGLU, AGT, AGTR1, AMBP
30iohexol4510.6NAGLU, AMBP
31kininogen4510.6CLEC3B, AMBP, KLK1
32olmesartan45 29 1112.6AGTR1, AGT
33colchicine60 45 2 29 1114.6UMOD, AGT, NAGLU
34prostaglandin4510.6AMBP, AGTR2, AGTR1, AGT
35oxalate4510.6UMOD, NAGLU
36thromboxane a245 2411.6AGTR1, AGT, NAGLU
37potassium45 11 2412.5NAGLU, AGT, AGTR1, UMOD, AMBP
38trichloroethylene4510.5AMBP, NAGLU
39sodium45 2411.5AMBP, UMOD, AGTR2, AGTR1, AGT, NAGLU
40creatinine4510.5AMBP, UMOD, AGTR2, AGTR1, AGT, NAGLU
41cyclosporin a45 29 6012.5AMBP, AGTR2, AGTR1, AGT, NAGLU
42ulinastatin4510.5AMBP, NAGLU
43lisinopril45 11 2412.5AGT, AGTR1
44heparin45 29 11 2413.5UMOD, AGTR1, AGT, NAGLU, CLEC3B
45verapamil45 50 29 11 2414.3NAGLU, AGTR1, AMBP
46sulfate45 2411.3AMBP, UMOD, NAGLU
47glucose4510.3AMBP, UMOD, AGTR1, AGT, NAGLU, INSRR
48urea45 11 2412.3NAGLU, UMOD, AMBP
49chymostatin4510.2AGT, AGTR1
50atenolol45 29 50 11 2414.0AGT, AGTR1

GO Terms for genes affiliated with Vesicoureteral Reflux

Sources:
16Gene Ontology
See all sources

Cellular components related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:01632410.1UPK3A, UPK2, UPK1A, UPK1B, UMOD

Biological processes related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of metanephros sizeGO:03556610.7PAX2, AGTR2
2positive regulation of NAD(P)H oxidase activityGO:03386410.7AGT, AGTR1
3positive regulation of metanephric glomerulus developmentGO:07230010.7PAX2, AGTR2
4regulation of blood vessel size by renin-angiotensinGO:00203410.7AGT, AGTR1
5cell growth involved in cardiac muscle cell developmentGO:06104910.6AGTR2, AGT
6renin-angiotensin regulation of aldosterone productionGO:00201810.6AGTR2, AGT, AGTR1
7cellular sodium ion homeostasisGO:00688310.6AGTR2, AGT
8positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.6AGTR2, PAX2, AGT
9regulation of renal sodium excretionGO:03581310.6AGTR1, AGT
10negative regulation of neurotrophin TRK receptor signaling pathwayGO:05138710.6AGT, AGTR2
11metanephric distal convoluted tubule developmentGO:07222110.6PAX2, UMOD
12positive regulation of cholesterol esterificationGO:01087310.6AGT, AGTR1
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:00719910.6AGT, AGTR2
14epithelial cell differentiationGO:03085510.5UPK1B, UPK3A, UPK1A, UPK2
15low-density lipoprotein particle remodelingGO:03437410.5AGTR1, AGT
16kidney developmentGO:00182210.5AGTR1, AGT, UPK3A
17positive regulation of cellular protein metabolic processGO:03227010.5AGTR1, AGT
18positive regulation of renal sodium excretionGO:03581510.4AGT, AGTR2
19positive regulation of macrophage derived foam cell differentiationGO:01074410.3AGTR1, AGT
20regulation of vasoconstrictionGO:01922910.3AGTR1, AGT
21nitric oxide mediated signal transductionGO:00726310.3AGTR2, AGT
22negative regulation of cell growthGO:03030810.0SOX17, AGT, AGTR2

Molecular functions related to Vesicoureteral Reflux according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.4AGTR1, AGTR2
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1

Products for genes affiliated with Vesicoureteral Reflux

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vesicoureteral Reflux

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet