MCID: VSC005
MIFTS: 53

Vesicoureteral Reflux malady

Categories: Genetic diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Vesicoureteral Reflux

Aliases & Descriptions for Vesicoureteral Reflux:

Name: Vesicoureteral Reflux 12 29 13 52 14
Vesico-Ureteral Reflux 12 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9620
ICD10 33 N13.7 N13.70
ICD9CM 35 593.7
MeSH 42 D014718
NCIt 47 C84467
UMLS 69 C0042580

Summaries for Vesicoureteral Reflux

Disease Ontology : 12 A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.

MalaCards based summary : Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to vesicoureteral reflux 2 and vesicoureteral reflux 3, and has symptoms including dysuria An important gene associated with Vesicoureteral Reflux is ROBO2 (Roundabout Guidance Receptor 2), and among its related pathways/superpathways are p70S6K Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hyaluronic acid and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and neutrophil, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Vesicoureteral reflux (VUR) is a condition in which urine flows retrograde, or backward, from the... more...

Related Diseases for Vesicoureteral Reflux

Diseases in the Vesicoureteral Reflux family:

Vesicoureteral Reflux 2 Vesicoureteral Reflux 4
Vesicoureteral Reflux 8 Vesicoureteral Reflux 3
Vesicoureteral Reflux 7 Vesicoureteral Reflux 5
Vesicoureteral Reflux 6 Vesicoureteral Reflux 1
Familial Vesicoureteral Reflux

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 vesicoureteral reflux 2 12.4
2 vesicoureteral reflux 3 12.4
3 vesicoureteral reflux 8 12.3
4 familial vesicoureteral reflux 12.3
5 vesicoureteral reflux 1 12.2
6 vesicoureteral reflux 5 12.1
7 vesicoureteral reflux 6 12.1
8 vesicoureteral reflux 4 12.1
9 vesicoureteral reflux 7 12.0
10 papillorenal syndrome 11.8
11 urofacial syndrome 1 11.0
12 urofacial syndrome 2 11.0
13 congenital anomalies of kidney and urinary tract 11.0
14 pelviureteric junction obstruction 11.0
15 hand-foot-uterus syndrome 11.0
16 hypotonia, ataxia, and delayed development syndrome 11.0
17 urethritis 10.4
18 neurogenic bladder 10.4
19 posterior urethral valves 10.4
20 pyelonephritis 10.4
21 hydronephrosis 10.3
22 acute pyelonephritis 10.3
23 congenital pulmonary airway malformation 10.2 AGTR2 PAX2
24 ureterocele 10.2
25 ureteral obstruction 10.2
26 penile cancer, childhood 10.2 ACE AGT
27 subleukemic leukemia 10.2 ACE TNXB
28 lipodystrophy, familial partial, type 1 10.1 CRP TGFB1
29 iron metabolism disease 10.1 ACE CRP
30 hypertrichosis of eyelid 10.1 ACE AGTR1 TGFB1
31 cystitis 10.1
32 spondyloarthropathy 2 10.1 ACE NAGLU
33 demyelinating polyneuropathy 10.1 AGTR1 AGTR2 TGFB1
34 diffuse large b-cell lymphoma 10.0 CRP TGFB1
35 iris disease 10.0 ACE AGT AGTR1
36 prostate neuroendocrine neoplasm 10.0 ACE AGT AGTR1
37 cascade stomach 10.0 ACE AGT AGTR1
38 hyperuricemic nephropathy, familial juvenile 2 10.0 ACE AGT AGTR1
39 eye degenerative disease 10.0 ACE AGT AGTR1
40 cetp-related hyperalphalipoproteinemia 10.0 ACE AGT AGTR1
41 joint disorders 10.0 ACE AGTR1 CRP
42 choroiditis 10.0 ACE CRP NAGLU
43 eastern equine encephalitis 10.0 ACE AGT AGTR1
44 aplasia cutis congenita recessive 10.0 ACE AGT AGTR1
45 laryngostenosis 10.0 ACE AGT AGTR1
46 testicular lymphoma 10.0 ACE CRP TGFB1
47 congenital nystagmus 10.0 ACE B2M
48 renal hypoplasia 10.0
49 epispadias 10.0
50 cerebral convexity meningioma 10.0 ACE AGT AGTR1

Comorbidity relations with Vesicoureteral Reflux via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Chronic Kidney Failure Deficiency Anemia
Hydronephrosis Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to Vesicoureteral Reflux

Symptoms & Phenotypes for Vesicoureteral Reflux

UMLS symptoms related to Vesicoureteral Reflux:


dysuria

MGI Mouse Phenotypes related to Vesicoureteral Reflux:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 PAX2 ROBO2 SOX17 TGFB1 TNXB ACE
2 homeostasis/metabolism MP:0005376 10.15 ACE AGT AGTR1 AGTR2 B2M CRP
3 growth/size/body region MP:0005378 10.06 ACE AGT AGTR1 AGTR2 B2M NAGLU
4 immune system MP:0005387 10.02 ACE AGT AGTR1 B2M CRP NAGLU
5 adipose tissue MP:0005375 9.93 AGT AGTR1 AGTR2 TGFB1 UMOD ACE
6 mortality/aging MP:0010768 9.9 AGT AGTR1 AGTR2 B2M NAGLU PAX2
7 liver/biliary system MP:0005370 9.73 ACE AGT B2M NAGLU SOX17 TGFB1
8 renal/urinary system MP:0005367 9.65 ACE AGT AGTR1 AGTR2 NAGLU PAX2
9 reproductive system MP:0005389 9.17 ACE AGT B2M PAX2 ROBO2 SOX17

Drugs & Therapeutics for Vesicoureteral Reflux

Drugs for Vesicoureteral Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 1,Phase 2 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 738-70-5 5578
4
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3 67-20-9 5353830
5
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 54575, 6560146 143
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
7 Adjuvants, Immunologic Phase 4
8 Folic Acid Antagonists Phase 4,Phase 3,Phase 1,Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
10 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Phase 1,Phase 2
11 Viscosupplements Phase 4
12 Vitamin B Complex Phase 4,Phase 3,Phase 1,Phase 2
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
14 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Protective Agents Phase 4,Phase 3
16 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2
17 Renal Agents Phase 4,Phase 3,Phase 1,Phase 2
18 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
19 Antitubercular Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2
21 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Folate Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
23 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
24
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
25
Cefixime Approved Phase 3 79350-37-1 54362 5362065
26 Coagulants Phase 3
27
Alginic acid Phase 3 9005-32-7
28 Hemostatics Phase 3
29 Radiation-Protective Agents Phase 3
30 Clavulanic Acid Phase 3
31 Amoxicillin-Potassium Clavulanate Combination Phase 3
32 beta-Lactamase Inhibitors Phase 3
33 carnitine Nutraceutical Phase 3
34 Pharmaceutical Solutions Phase 1, Phase 2
35
Pancrelipase Approved 53608-75-6
36
Midazolam Approved, Illicit 59467-70-8 4192
37 pancreatin
38 Anesthetics
39 Cephalosporins
40 Adjuvants, Anesthesia
41 GABA Agents
42 GABA Modulators
43 Neurotransmitter Agents
44 Tranquilizing Agents
45 Anesthetics, General
46 Anesthetics, Intravenous
47 Anti-Anxiety Agents
48 Hypnotics and Sedatives
49 Psychotropic Drugs
50 Central Nervous System Depressants

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children Unknown status NCT02271035 Phase 4
2 Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection Unknown status NCT00156546 Phase 4
3 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4
4 Phase III Study of Chondrocyte Alginate Gel Suspension in Pediatric Patients With Vesicoureteral Reflux Unknown status NCT00004487 Phase 3
5 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3
6 Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) Completed NCT00405704 Phase 3
7 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
8 Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract Recruiting NCT02021006 Phase 3
9 Antibiotic Prophylaxis in Children With Pyelonephritis Withdrawn NCT00752375 Phase 3
10 Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder Unknown status NCT02044965 Phase 1, Phase 2
11 Contrast Enhanced Ultrasound for Evaluation of Reflux Nephropathy Recruiting NCT02786810 Phase 2
12 CeVUS With Intravesical Administration of OPTISON TM (Trademark) in Children Active, not recruiting NCT02204917 Phase 1, Phase 2
13 Parent Education and Medical Play: A Comparison of Psychological Preparation Strategies for Voiding Cystourethrogram Unknown status NCT01578291 Phase 1
14 Determination of Voiding Patterns of Children With Vesicoureteral Reflux Unknown status NCT00186199
15 Protocol DIVAT-Uro Unknown status NCT01280708
16 Prospective Pediatric Vesicoureteral Reflux Surgery Database Completed NCT01373385
17 Efficacy of Endoscopic Subureteral Injection for Vesicoureteral Reflux in Adults With Decreased Bladder Compliance Completed NCT00815334
18 Polyacrylate Polyalcohol Copolymer for Vesicoureteral Reflux Completed NCT01926353
19 Reflux in Spinal Cord Injury Patients With Neurogenic Lower Urinary Tract Dysfunction Completed NCT01297673
20 Usefulness of Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux. Completed NCT00200616
21 The Long Term Follow-Up Results Of The Direct Nipple Ureteroneocystostomy Technique Completed NCT01780493
22 Incidence of Urinary Tract Infection After Urodynamic Investigation Completed NCT01297647
23 DVD-Based Training Program in Self-Hypnosis for Children Recruiting NCT01483105
24 Change of Urinary Metabolic Profile Secondary to a Congenital Urine Flow Impairment (UFI) by Nuclear Magnetic Resonance (NMR) and Metabolomics Analysis Active, not recruiting NCT02792348
25 Clinical Applications of Contrast-Enhanced Ultrasonography in Pediatric Population - Intravesicle Administration Not yet recruiting NCT02986477
26 Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis Not yet recruiting NCT02825485
27 Midazolam Effect in Children Undergoing Voiding Cystourethrogram (VCUG) Terminated NCT00894465
28 Study of Endoscopic Versus Open Surgery for Urinary Reflux Withdrawn NCT00830479
29 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929
30 (ARFI) Shear Velocity Imaging of the Kidneys in Pediatric Patients Withdrawn NCT01781819

Search NIH Clinical Center for Vesicoureteral Reflux

Cochrane evidence based reviews: vesico-ureteral reflux

Genetic Tests for Vesicoureteral Reflux

Genetic tests related to Vesicoureteral Reflux:

id Genetic test Affiliating Genes
1 Vesicoureteral Reflux 29

Anatomical Context for Vesicoureteral Reflux

MalaCards organs/tissues related to Vesicoureteral Reflux:

39
Kidney, Testes, Neutrophil, Spinal Cord

Publications for Vesicoureteral Reflux

Articles related to Vesicoureteral Reflux:

(show top 50) (show all 732)
id Title Authors Year
1
An Operative Technique for the Correction of Vesicoureteral Reflux. ( 28012771 )
2017
2
Current status of robotic-assisted surgery for the treatment of vesicoureteral reflux in children. ( 27764016 )
2017
3
To screen or not to screen for vesicoureteral reflux in children with ureteropelvic junction obstruction: a systematic review. ( 27888411 )
2017
4
Surgical Correction of Vesicoureteral Reflux. ( 28010982 )
2017
5
Transplantation of mature adipocyte-derived dedifferentiated fat cells for the treatment of vesicoureteral reflux in a rat model. ( 27683029 )
2016
6
Comparison of results of endoscopic correction of vesicoureteral reflux in children using two bulking substances: Dextranomer/hyaluronic acid copolymer (Deflux) versus polyacrylate-polyalcohol copolymer (Vantris). ( 27593921 )
2016
7
Computer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux. ( 27072485 )
2016
8
Augmentation enterocystoplasty without reimplantation for patients with neurogenic bladder and vesicoureteral reflux. ( 27377846 )
2016
9
Polymorphisms in I+-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. ( 26940096 )
2016
10
Color-Doppler sonographic tissue perfusion measurements reveal significantly diminished renal cortical perfusion in kidneys with vesicoureteral reflux. ( 27051133 )
2016
11
Clinical and Radiological Risk Factors Predicting Open Surgical Repair in Pediatric Patients with Dilating Vesicoureteral Reflux. ( 27320684 )
2016
12
Prevesical Calcification and Hydronephrosis in a Girl Treated for Vesicoureteral Reflux. ( 27408905 )
2016
13
Comparison of dextranomer/hyaluronic acid based bulking agents in the treatment of vesicoureteral reflux in children: Deflux versus Vurdex. ( 27347628 )
2016
14
Dimercaptosuccinic acid scan challenges in childhood urinary tract infection, vesicoureteral reflux and renal scarring investigation and management. ( 27355216 )
2016
15
Accuracy of ultrasonography in predicting vesicoureteral reflux in children: A meta-analysis. ( 27310111 )
2016
16
Probabilities of Dilating Vesicoureteral Reflux in Children with First-time Simple Febrile Urinary Tract Infection and Normal Renal and Bladder Ultrasound. ( 27181502 )
2016
17
Polyacrylamide Hydrogel as a Bulking Agent for the Endoscopic Treatment of Vesicoureteral Reflux: Long-Term Results and Safety. ( 27575606 )
2016
18
Role of new biomarkers for predicting renal scarring in vesicoureteral reflux: NGAL, KIM-1, and L-FABP. ( 26324091 )
2016
19
Correction: Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux. ( 27861580 )
2016
20
ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia. ( 27002985 )
2016
21
Reliability of the Grading System for Voiding Cystourethrograms in the Management of Vesicoureteral Reflux: An Interrater Comparison. ( 27069475 )
2016
22
Diagnosis of vesicoureteral reflux according to the 1999 and 2011 guidelines of the Subcommittee on Urinary Tract Infection of the American Academy of Pediatrics. ( 27079390 )
2016
23
Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFI^1 and GNB3 with the occurrence of primary vesicoureteral reflux. ( 27988909 )
2016
24
Genetics of Vesicoureteral Reflux. ( 27013925 )
2016
25
Secondary surgery for vesicoureteral reflux after failed endoscopic injection: Comparison to primary surgery. ( 26966727 )
2016
26
Extravesical (modified Gregoir Lich) versus intravesical (Cohen's) ureteric reimplantation for vesicoureteral reflux in children: A single center experience. ( 27843215 )
2016
27
Management of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid in Adults. ( 27162514 )
2016
28
Evaluation of Mathisen's technique for ureteral reimplantation in children with primary vesicoureteral reflux. ( 27430662 )
2016
29
Long-term impact of unilateral hypo/dysplastic kidney in infants with primary vesicoureteral reflux. ( 27106531 )
2016
30
Dimercaptosuccinic acid scan or ultrasound in screening for vesicoureteral reflux among children with urinary tract infections. ( 27378557 )
2016
31
Prenatal ultrasound diagnosis of 1 case of vesicoureteral reflux. ( 27429918 )
2016
32
Routine delayed voiding cystourethography after initial successful endoscopic treatment with Dextranomer/Hialuronic Acid Copolimer (Dx/HA) of vesicoureteral reflux (VUR). Is it necessary? ( 27161091 )
2016
33
Emphysematous pyelitis and cystitis associated with vesicoureteral reflux in a diabetic dog. ( 27041755 )
2016
34
Prediction of High-grade Vesicoureteral Reflux in Children Younger Than 2 Years Using Renal Sonography: A Preliminary Study. ( 26960798 )
2016
35
Antibiotic prophylaxis for prevention of febrile urinary tract infections in children with vesicoureteral reflux: a meta-analysis of randomized, controlled trials comparing dilated to nondilated vesicoureteral reflux. ( 27620895 )
2016
36
Delayed upper tract drainage on voiding cystourethrogram may not be associated with increased risk of urinary tract infection in children with vesicoureteral reflux. ( 27492248 )
2016
37
Urinary tract infection in the setting of vesicoureteral reflux. ( 27408706 )
2016
38
Reliability of grading of vesicoureteral reflux and other findings on voiding cystourethrography. ( 27666144 )
2016
39
Contemporary Management of Vesicoureteral Reflux. ( 27570729 )
2016
40
The comparison of dextranomer/hyaluronic acid and polyacrylate-polyalcohol copolymers in endoscopic treatment of vesicoureteral reflux. ( 27061353 )
2016
41
Posterior urethral valves and vesicoureteral reflux: can prenatal ultrasonography distinguish between these two conditions in male fetuses? ( 27374758 )
2016
42
Endoscopic treatment of grades IV and V vesicoureteral reflux with two bulking substances: Dextranomer hyaluronic acid copolymer versus polyacrylate polyalcohol copolymer in children. ( 27117052 )
2016
43
Cross-fused renal ectopia associated with vesicoureteral reflux; a case report. ( 27689123 )
2016
44
STING versus HIT technique of endoscopic treatment for vesicoureteral reflux: A systematic review and meta-analysis. ( 27773360 )
2016
45
Urinary L-FABP as a marker of vesicoureteral reflux in children: could it also have a protective effect on the kidney? ( 27550232 )
2016
46
Prediction of High-grade Vesicoureteral Reflux in Children Younger Than 2 Years Using Renal Sonography: A Preliminary Study. ( 28027609 )
2016
47
Vesicoureteral reflux and the extracellular matrix connection. ( 27139901 )
2016
48
Vesicoureteral Reflux: How to Interpret Different Studies with Different Results. ( 27424816 )
2016
49
Ureteral Embolization to Prevent Thrombotic Obstruction of Nephrostomy Catheters in the Context of Refractory Hemorrhagic Radiation Cystitis with Severe Vesicoureteral Reflux. ( 27019759 )
2016
50
Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. ( 27342956 )
2016

Variations for Vesicoureteral Reflux

Expression for Vesicoureteral Reflux

Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for Vesicoureteral Reflux

GO Terms for Vesicoureteral Reflux

Cellular components related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ACE AGT B2M CRP TGFB1 TNXB
2 extracellular region GO:0005576 9.56 ACE AGT AGTR2 B2M CRP TGFB1
3 extracellular exosome GO:0070062 9.28 ACE AGT B2M CRP NAGLU ROBO2

Biological processes related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

(show all 39)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 9.83 AGT AGTR2 SOX17 TGFB1
2 regulation of blood pressure GO:0008217 9.78 ACE AGT AGTR2
3 blood vessel remodeling GO:0001974 9.71 ACE AGT AGTR2
4 endoderm development GO:0007492 9.68 SOX17 TGFB1
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.68 ACE B2M
6 positive regulation of protein tyrosine kinase activity GO:0061098 9.67 ACE AGT
7 positive regulation of vasodilation GO:0045909 9.67 AGT AGTR2
8 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.67 AGT AGTR2
9 vasodilation GO:0042311 9.66 AGT AGTR2
10 nitric oxide mediated signal transduction GO:0007263 9.66 AGT AGTR2
11 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.65 AGT AGTR1
12 negative regulation of blood vessel endothelial cell migration GO:0043537 9.65 AGTR2 TGFB1
13 low-density lipoprotein particle remodeling GO:0034374 9.65 AGT AGTR1
14 positive regulation of renal sodium excretion GO:0035815 9.64 AGT AGTR2
15 cellular sodium ion homeostasis GO:0006883 9.64 AGT AGTR2
16 angiotensin maturation GO:0002003 9.63 ACE AGT
17 regulation of blood vessel diameter GO:0097746 9.62 ACE AGTR1
18 positive regulation of cholesterol esterification GO:0010873 9.62 AGT AGTR1
19 cell growth involved in cardiac muscle cell development GO:0061049 9.61 AGT AGTR2
20 regulation of vasoconstriction GO:0019229 9.61 ACE AGT AGTR1
21 angiotensin-activated signaling pathway GO:0038166 9.6 AGTR1 AGTR2
22 positive regulation of NAD(P)H oxidase activity GO:0033864 9.59 AGT AGTR1
23 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.58 AGT AGTR2
24 regulation of renal sodium excretion GO:0035813 9.58 AGT AGTR1
25 positive regulation of cellular protein metabolic process GO:0032270 9.58 AGT AGTR1 TGFB1
26 metanephric distal convoluted tubule development GO:0072221 9.57 PAX2 UMOD
27 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.56 AGT AGTR1
28 positive regulation of metanephric glomerulus development GO:0072300 9.55 AGTR2 PAX2
29 kidney development GO:0001822 9.55 ACE AGT AGTR1 ROBO2 UPK3A
30 regulation of vasodilation GO:0042312 9.54 ACE AGTR1 AGTR2
31 regulation of renal output by angiotensin GO:0002019 9.51 ACE AGT
32 positive regulation of superoxide anion generation GO:0032930 9.5 AGT CRP TGFB1
33 mononuclear cell proliferation GO:0032943 9.49 ACE TGFB1
34 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.48 AGT AGTR2
35 regulation of metanephros size GO:0035566 9.46 AGTR2 PAX2
36 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGT AGTR1
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.13 AGT AGTR1 AGTR2
38 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 8.92 AGT AGTR2 PAX2 TGFB1
39 positive regulation of transcription, DNA-templated GO:0045893 10.03 AGT AGTR2 PAX2 SOX17 TGFB1

Molecular functions related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 angiotensin type II receptor activity GO:0004945 8.96 AGTR1 AGTR2
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Vesicoureteral Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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