Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 11 13 68
 
Pigmented Villonodular Synovitis 68

Classifications:



External Ids:

Disease Ontology11 DOID:9898
ICD1030 M12.20, M12.2
ICD9CM32 719.2, 719.20

Summaries for Villonodular Synovitis

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Wikipedia:71 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to malignant giant cell tumor and pigmented villonodular synovitis, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are Osteoclast Signaling and Rheumatoid arthritis. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance.

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1malignant giant cell tumor29.3ACP5, CSF1R, MMP9, PTPRC, TNFSF11
2pigmented villonodular synovitis12.8
3noonan syndrome 111.7
4synovitis11.2
5noonan syndrome 411.1
6giant cell tumor10.5
7tenosynovial giant cell tumor10.4
8arthritis10.2
9rheumatoid arthritis10.2
10corneal staphyloma10.2ACP5, MMP9
11synovial chondromatosis10.2
12spastic hemiplegia10.1MMP9, TNFSF11
13microcephaly 10, primary, autosomal recessive10.1ACP5, TNFSF11
14maroteaux stanescu cousin syndrome10.1ACP5, TNFSF11
15bronchus cancer10.1ACP5, TNFSF11
16central nervous system adult germ cell tumor10.1MMP9, VIM
17statin toxicity10.1MMP9, TNFSF11
18acrorenal syndrome10.1ACP5, TNFSF11
19persistent mullerian duct syndrome10.1CSF1R, MMP9
20chromosomal disease10.1ACP5, TNFSF11
21onychocytic matricoma10.1MMP9, VIM
22dysbaric osteonecrosis10.1ACP5, TNFSF11
23osteonecrosis10.1
24sarcoma10.1
25tuberculosis10.1
26neuropathy10.1
27classic type lipoma10.0ACP5, TNFSF11
28ischemic bone disease10.0ACP5, TNFSF11
29plague10.0MMP9, TNFSF11
30chiasmal syndrome10.0ACP5, PTPRC
31gerstmann syndrome10.0CSF1R, VIM
32hemangioma of liver10.0ACP5, PTPRC
33vascular dementia10.0MMP9, TNFSF11
34bladder papillary transitional cell neoplasm10.0ACP5, TNFSF11
35bulbomembranous urethral cancer10.0ACP5, MMP9, TNFSF11
36hemarthrosis10.0
37autistic disorder10.0ACP5, MMP9, TNFSF11
38intrahepatic cholestasis10.0MMP9, TNFSF11
39hinman syndrome10.0PTPRC, VIM
40ribbing disease10.0PTPRC, VIM
41appendix mucinous cystadenocarcinoma9.9PTPRC, VIM
42omodysplasia 29.9PTPRC, VIM
43congenital muscular dystrophy with hyperlaxity9.9PTPRC, VIM
44lung benign neoplasm9.9PTPRC, VIM
45desmoid tumor9.9PTPRC, VIM
46kidney benign neoplasm9.9PTPRC, VIM
47diabetes persistent mullerian ducts9.9PTPRC, VIM
48glossopharyngeal nerve disease9.9CSF1R, PTPRC
49systemic lupus erythematosus9.8
50chediak-higashi syndrome9.8

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms & Phenotypes for Villonodular Synovitis

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UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00055-A-19.7ACP5, CSF1R, VIM
2GR00210-A8.9ACP5, CSF1R, PTPRC, VIM

MGI Mouse Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4CSF1R, MMP9, PTPRC, TNFSF11, VIM
2MP:00053878.3CSF1R, MMP9, PTPRC, TNFSF11, VIM
3MP:00053888.1MMP9, PTPRC, TNFSF11, VIM

Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 1, Phase 26394
2ImmunoglobulinsPhase 1, Phase 26394
3Grapefruit Seed ExtractNutraceuticalPhase 242
4
Paclitaxelapproved, vet_approvedPhase 1286433069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
5Antineoplastic Agents, PhytogenicPhase 15602
6Albumin-Bound PaclitaxelPhase 12864
7Antimitotic AgentsPhase 15657

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1
8Tenosynovial Giant Cell Tumors (TGCT) Observational Platform ProjectRecruitingNCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

36
Bone, Testes, Lung

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). (28057477)
2017
2
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. (27928593)
2016
3
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. (26919624)
2016
4
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. (27169531)
2016
5
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. (28032093)
2016
6
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. (27130398)
2016
7
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. (27499236)
2016
8
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. (27843734)
2016
9
Villonodular synovitis shoulder complicated by rotator cuff rupture. (27068614)
2016
10
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. (27517031)
2016
11
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. (28005642)
2016
12
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. (26820289)
2016
13
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. (27190776)
2016
14
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. (26810732)
2016
15
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. (27509331)
2016
16
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. (26761914)
2016
17
Multifocal pigmented villonodular synovitis in a child: A case report. (27537585)
2016
18
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. (27462929)
2016
19
Villonodular synovitis of the ankle. Analysis of the risk of recurrence. (27197681)
2016
20
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. (27866235)
2016
21
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. (27200236)
2016
22
Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. (25510167)
2015
23
Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. (25465190)
2015
24
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. (27299078)
2015
25
A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome. (25967956)
2015
26
Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst. (27299073)
2015
27
Use of yttrium-90 hydroxyapatite radiosynovectomy as a primary modality of treatment in diffuse pigmented villonodular synovitis of the knee joint: A first case report. (25589806)
2015
28
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. (26430437)
2015
29
Pigmented Villonodular Synovitis: Potential Pitfall on Oncologic 18F-FDG PET/CT. (26164181)
2015
30
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
31
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. (26067150)
2015
32
Arthroscopic T-capsulotomy for Excision of Pigmented Villonodular Synovitis in the Hip. (25901612)
2015
33
Recurrent pigmented villonodular synovitis and multifocal giant cell tumor of the tendon sheath: case report. (25577961)
2015
34
Surgical outcomes after excision of pigmented villonodular synovitis localized to the ankle and hindfoot without adjuvant therapy. (25618808)
2015
35
Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis. (26819567)
2015
36
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
37
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. (25637030)
2015
38
Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. (25854167)
2015
39
Surgical treatment of diffuse pigmented villonodular synovitis of the knee. (25936715)
2015
40
Primary synovial epithelioid sarcoma of the knee: distinctly unusual location leading to its confusion with pigmented villonodular synovitis. (25801084)
2015
41
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. (26440548)
2015
42
Pigmented villonodular synovitis of temporomandibular joint: pathological aspects and surgical treatment. (25937582)
2015
43
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
44
The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. (25820897)
2015
45
Dual-energy computed tomography molecular imaging of pigmented villonodular synovitis. (25504960)
2015
46
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. (26219971)
2015
47
Bilateral pigmented villonodular synovitis of the knee. (26649121)
2015
48
Pigmented villonodular synovitis of the temporomandibular joint: Case report and review of literature. (25821131)
2015
49
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. (26052431)
2015
50
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension. (25699525)
2015

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:003022510.1CSF1R, MMP9
2bone resorptionGO:004545310.0ACP5, TNFSF11
3ossificationGO:00015039.9MMP9, TNFSF11
4osteoclast differentiationGO:00303169.4CSF1R, TNFSF11

Sources for Villonodular Synovitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet