Aliases & Classifications for Villonodular Synovitis

MalaCards integrated aliases for Villonodular Synovitis:

Name: Villonodular Synovitis 12 14 69
Pigmented Villonodular Synovitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD10 33 M12.20 M12.2
ICD9CM 35 719.2 719.20
UMLS 69 C0158168

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to neuropathy and malignant giant cell tumor, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and MicroRNAs in cancer. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and muscle

Wikipedia : 72 Villonodular synovitis is a type of synovial... more...

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.6 MMP9 TNFSF11
2 malignant giant cell tumor 28.4 ACP5 MMP9 PTPN11 TNFSF11
3 pigmented villonodular synovitis 12.8
4 noonan syndrome 1 11.7
5 synovitis 11.2
6 noonan syndrome 4 11.1
7 giant cell tumor 10.5
8 progressive multifocal leukoencephalopathy 10.4 PTPN11 SOS1
9 cervical serous adenocarcinoma 10.4 PTPN11 SOS1
10 tenosynovial giant cell tumor 10.4
11 growth restriction, severe, with distinctive facies 10.3 PTPN11 SOS1
12 arthritis 10.2
13 noonan syndrome 7 10.2 PTPN11 SOS1
14 rheumatoid arthritis 10.2
15 childhood endodermal sinus tumor 10.2 MMP9 VIM
16 fibula aplasia complex brachydactyly 10.2 SOS1 VIM
17 oligomeganephronic renal hypoplasia 10.2 MMP9 VIM
18 synovial chondromatosis 10.2
19 fryns macrocephaly 10.1 ACP5 PTPN11
20 cri-du-chat syndrome 10.1 ACP5 PTPN11
21 cystitis 10.1 MMP9 VIM
22 corneal staphyloma 10.1 ACP5 MMP9
23 osteonecrosis 10.1
24 sarcoma 10.1
25 tuberculosis 10.1
26 leopard syndrome 1 10.0 PTPN11 SOS1
27 hemarthrosis 10.0
28 cortical blindness 9.9 TNFSF11 VIM
29 lipoid nephrosis 9.9 MMP9 TNFSF11
30 oral antidiabetic drugs toxicity or dose selection 9.8 MMP9 TNFSF11
31 systemic lupus erythematosus 9.8
32 chediak-higashi syndrome 9.8
33 tendinitis 9.8
34 hemangioma 9.8
35 osteoarthritis 9.8
36 lymphoma 9.8
37 squamous cell carcinoma 9.8
38 melanoma 9.8
39 cervicitis 9.8
40 chondroblastoma 9.8
41 nodular tenosynovitis 9.8
42 malignant giant cell tumor of the tendon sheath 9.8
43 peroneal neuropathy 9.8
44 bone giant cell tumor 9.8
45 ulnar neuropathy 9.8
46 paraplegia 9.8
47 epithelioid sarcoma 9.8
48 conjunctivitis 9.8
49 spondylitis 9.8
50 lupus erythematosus 9.8

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.47 VIM
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.47 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.47 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.47 SOS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.47 SOS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.47 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 SOS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.47 SOS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 SOS1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 SOS1 TNFSF11 VIM
13 Decreased cell migration GR00055-A-1 9.33 VIM ACP5 SOS1
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 ACP5 PTPN11 VIM

MGI Mouse Phenotypes related to Villonodular Synovitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.55 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 respiratory system MP:0005388 9.26 MMP9 PTPN11 TNFSF11 VIM
3 vision/eye MP:0005391 9.02 MMP9 PTPN11 SOS1 TNFSF11 VIM

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 1
6 Antimitotic Agents Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397 capsule;Placebo capsule matching PLX3397 capsule
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Recruiting NCT01643850 Phase 2 MCS110;Placebo
4 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2 FPA008
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1 Paclitaxel;RO5509554
7 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Active, not recruiting NCT02673736 Phase 1 PLX73086
8 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

39
Bone, Testes, Lung

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 608)
id Title Authors Year
1
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
2
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
3
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
4
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
5
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
6
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
7
Pigmented Villonodular Synovitis of the Temporomandibular Joint With Petrous Bone Invasion. ( 28333775 )
2017
8
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
9
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
10
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis. ( 28764182 )
2017
11
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
12
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
13
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
14
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
15
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
16
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
17
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
18
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
19
Pigmented villonodular synovitis of the hip. ( 28461957 )
2016
20
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
21
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
22
Multifocal pigmented villonodular synovitis in a child: A case report. ( 27537585 )
2016
23
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. ( 27200236 )
2016
24
Villonodular synovitis shoulder complicated by rotator cuff rupture. ( 27068614 )
2016
25
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. ( 27190776 )
2016
26
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
27
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. ( 28032093 )
2016
28
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
29
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
30
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. ( 26919624 )
2016
31
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
32
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
33
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
34
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. ( 26810732 )
2016
35
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016
36
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report. ( 28824995 )
2016
37
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
38
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. ( 27462929 )
2016
39
Villonodular synovitis of the ankle. Analysis of the risk of recurrence. ( 27197681 )
2016
40
Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. ( 25510167 )
2015
41
A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome. ( 25967956 )
2015
42
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. ( 26553457 )
2015
43
Arthroscopic T-capsulotomy for Excision of Pigmented Villonodular Synovitis in the Hip. ( 25901612 )
2015
44
Pigmented villonodular synovitis of the elbow with rdial, median and ulnar nerve compression. ( 26823718 )
2015
45
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. ( 26219971 )
2015
46
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. ( 25459320 )
2015
47
Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. ( 25854167 )
2015
48
Arthroscopic technique for the treatment of pigmented villonodular synovitis of the hip. ( 25973372 )
2015
49
The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. ( 25820897 )
2015
50
Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis. ( 26819567 )
2015

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 12.19 MMP9 SOS1 VIM
3
Show member pathways
12.14 PTPN11 SOS1 TNFSF11
4
Show member pathways
12.06 PTPN11 SOS1 VIM
5 11.81 MMP9 PTPN11 SOS1
6
Show member pathways
11.6 PTPN11 SOS1
7
Show member pathways
11.57 PTPN11 SOS1
8 11.56 ACP5 TNFSF11
9 11.48 MMP9 PTPN11
10
Show member pathways
11.42 PTPN11 SOS1
11
Show member pathways
11.37 PTPN11 SOS1
12 11.31 PTPN11 SOS1
13 11.27 PTPN11 SOS1
14 11.2 PTPN11 SOS1
15 11.18 PTPN11 SOS1
16 11.1 PTPN11 SOS1
17
Show member pathways
11.07 PTPN11 SOS1 TNFSF11
18 11.01 PTPN11 SOS1
19
Show member pathways
10.93 PTPN11 SOS1
20 10.88 PTPN11 SOS1
21 10.82 MMP9 SOS1
22 10.77 PTPN11 SOS1
23 10.47 MMP9 PTPN11 SOS1
24 10.46 ACP5 TNFSF11

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.46 MMP9 TNFSF11
2 ephrin receptor signaling pathway GO:0048013 9.43 MMP9 PTPN11
3 leukocyte migration GO:0050900 9.43 MMP9 PTPN11 SOS1
4 multicellular organism growth GO:0035264 9.4 PTPN11 SOS1
5 epidermal growth factor receptor signaling pathway GO:0007173 9.37 PTPN11 SOS1
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.32 MMP9 SOS1
7 bone resorption GO:0045453 9.16 ACP5 TNFSF11
8 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 PTPN11 SOS1
9 Bergmann glial cell differentiation GO:0060020 8.62 PTPN11 VIM

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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