Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 11 13 66
 
Pigmented Villonodular Synovitis 66

Classifications:



External Ids:

Disease Ontology11 DOID:9898
ICD1028 M12.20, M12.2
ICD9CM30 719.2, 719.20

Summaries for Villonodular Synovitis

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Wikipedia:69 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to rheumatoid arthritis and malignant giant cell tumor, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are CXCR4-mediated signaling events and Plasma membrane estrogen receptor signaling. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are muscle and immune system.

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.8ACP5, MMP1, MMP9, TNFSF11
2malignant giant cell tumor28.6ACP5, MMP1, MMP9, TNFSF11
3malignant giant cell tumor of the tendon sheath28.4ACP5, MMP9, PTPN11, TNFSF11
4pigmented villonodular synovitis12.8
5noonan syndrome 111.6
6synovitis11.3
7giant cell tumor10.6
8tenosynovial giant cell tumor10.5
9pterygium colli mental retardation digital anomalies10.4PTPN11, SOS1
10rad51c-related fanconi anemia10.4PTPN11, SOS1
11cervical adenoid basal carcinoma10.4PTPN11, SOS1
12pancreatic serous cystadenocarcinoma10.4PTPN11, SOS1
13arthritis10.4
14growth restriction, severe, with distinctive facies10.4PTPN11, SOS1
15synovial chondromatosis10.3
16fibromatosis, gingival, 110.3MMP1, SOS1
17leopard syndrome 110.3PTPN11, SOS1
18salt and pepper syndrome10.3MMP1, SOS1
19pathological gambling10.3MMP1, MMP9
20echinococcosis10.3MMP1, SOS1
21classic endocrine tumor of appendix10.2MMP1, MMP9
22emphysematous cholecystitis10.2MMP1, MMP9
23mechanical ectropion10.2MMP1, MMP9
24juvenile astrocytoma10.2MMP1, MMP9
25limb reduction defect10.2MMP1, MMP9
26retinal degeneration10.2MMP1, MMP9
27adenosine monophosphate deaminase 1 deficiency10.2MMP1, MMP9
28pauciarticular onset juvenile idiopathic arthritis10.2MMP1, MMP9
29noonan syndrome 410.2
30benign hypertensive renal disease10.2MMP1, MMP9
31sarcoma10.2
32tuberculosis10.2
33neuropathy10.2
34noonan syndrome 710.2PTPN11, SOS1
35fryns macrocephaly10.2ACP5, PTPN11
36stromal keratitis10.2MMP1, MMP9
37neuropathy, ataxia, and retinitis pigmentosa10.2ACP5, PTPN11
38pulmonary sarcoidosis10.2MMP1, MMP9
39cyclosporiasis10.1ACP5, MMP9
40mastoiditis10.1MMP1, MMP9
41osteonecrosis10.1
42hemarthrosis10.1
43glossopharyngeal nerve neoplasm10.1MMP1, MMP9
44hodgkin's granuloma10.0MMP1, MMP9
45lung hilum cancer10.0MMP1, MMP9
46uv-sensitive syndrome 310.0PTPN11, TNFSF11
47pilocytic astrocytoma of cerebellum10.0PTPN11, SOS1
48lipoid nephrosis9.9MMP9, TNFSF11
49systemic lupus erythematosus9.9
50chediak-higashi syndrome9.9

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PaclitaxelPhase 1269133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1
8A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

34
Bone, Testes, Lung

Animal Models for Villonodular Synovitis or affiliated genes

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MGI Mouse Phenotypes related to Villonodular Synovitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3MMP9, PTPN11, SOS1, TNFSF11
2MP:00053877.4MMP1, MMP9, PTPN11, SOS1, TNFSF11

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. (27509331)
2016
2
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. (27190776)
2016
3
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. (27299078)
2015
4
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
5
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
6
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. (26052431)
2015
7
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
8
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. (25637030)
2015
9
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. (26430437)
2015
10
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
11
A rare case of extensive diffuse nonpigmented villonodular synovitis as a cause of total knee arthroplasty failure. (24892248)
2014
12
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
13
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
14
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
15
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
16
Pigmented villonodular synovitis of the temporomandibular joint: a radiologic diagnosis and case report. (21783297)
2012
17
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
18
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
19
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
20
Pigmented villonodular synovitis of the pes anserine bursa. (17665791)
2007
21
Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instability. Case report and review of the literature. (17688068)
2007
22
Clustered localized pigmented villonodular synovitis. (15944639)
2005
23
Villonodular synovitis (PVNS) of the spine. (15703944)
2005
24
Localized pigmented villonodular synovitis in the anteromedial compartment of the knee associated with cartilage lesions of the medial femoral condyle: report of a case and review of the literature. (14749916)
2005
25
Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour. (15903030)
2005
26
Pigmented villonodular synovitis: an uncommon presentation of anterior hip pain. (15668561)
2005
27
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
28
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
29
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
30
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
31
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
32
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
33
Localized pigmented villonodular synovitis involving the fat pad of the knee. (11281333)
2000
34
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
35
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
36
Pigmented villonodular synovitis of the elbow. (9524343)
1998
37
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
38
Localized pigmented villonodular synovitis of the patellar fat pad: a report of two cases. (7945635)
1994
39
Pigmented villonodular synovitis of the sequestered suprapatellar bursa. (8070197)
1994
40
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
41
Pigmented villonodular synovitis and synovial cysts of the spine [ comment]. (1595437)
1992
42
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
43
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
44
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
45
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
46
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
47
Radiologic case study. Diffuse pigmented villonodular synovitis. (2771816)
1989
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Magnetic resonance imaging of pigmented villonodular synovitis: a report of two cases. (3616670)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathwaysScoreTop Affiliating Genes
19.6MMP9, PTPN11
29.5MMP9, SOS1
39.5MMP1, MMP9
49.5MMP1, MMP9
59.5MMP1, MMP9
69.5MMP1, MMP9
79.5MMP1, MMP9
89.5PTPN11, SOS1
99.5PTPN11, SOS1
109.5PTPN11, SOS1
11
Show member pathways
9.5PTPN11, SOS1
12
Show member pathways
9.5PTPN11, SOS1
139.5PTPN11, SOS1
149.5PTPN11, SOS1
159.5PTPN11, SOS1
16
Show member pathways
9.5PTPN11, SOS1
179.5PTPN11, SOS1
189.5PTPN11, SOS1
199.5PTPN11, SOS1
209.1MMP9, PTPN11, SOS1
219.1MMP9, PTPN11, SOS1
229.1MMP9, PTPN11, SOS1
239.0ACP5, TNFSF11
249.0MMP1, MMP9, SOS1
259.0MMP1, MMP9, SOS1
26
Show member pathways
9.0MMP1, PTPN11, SOS1
27
Show member pathways
9.0MMP1, PTPN11, SOS1
28
Show member pathways
9.0MMP1, PTPN11, SOS1
29
Show member pathways
8.7MMP9, SOS1, TNFSF11
308.7PTPN11, SOS1, TNFSF11
31
Show member pathways
8.7PTPN11, SOS1, TNFSF11
328.5ACP5, MMP1, TNFSF11

GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.8MMP1, MMP9
2neurotrophin TRK receptor signaling pathwayGO:00480119.7PTPN11, SOS1
3epidermal growth factor receptor signaling pathwayGO:00071739.7PTPN11, SOS1
4extracellular matrix disassemblyGO:00226179.7MMP1, MMP9
5multicellular organism growthGO:00352649.6PTPN11, SOS1
6ephrin receptor signaling pathwayGO:00480139.6MMP9, PTPN11
7bone resorptionGO:00454539.3ACP5, TNFSF11
8osteoclast differentiationGO:00303169.3ACP5, TNFSF11
9positive regulation of epidermal growth factor receptor signaling pathwayGO:00457429.2MMP9, SOS1
10leukocyte migrationGO:00509008.6MMP1, MMP9, PTPN11, SOS1
11ossificationGO:00015038.5ACP5, MMP9, TNFSF11

Molecular functions related to Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:00041759.5MMP1, MMP9

Sources for Villonodular Synovitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet