MCID: VLL003
MIFTS: 40

Villonodular Synovitis malady

Category: Bone diseases

Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 10 12 65
 
Pigmented Villonodular Synovitis 65

Classifications:



External Ids:

Disease Ontology10 DOID:9898
ICD1027 M12.20, M12.2
ICD9CM29 719.2, 719.20
UMLS65 C0158168

Summaries for Villonodular Synovitis

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Wikipedia:68 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to pigmented villonodular synovitis and entropion. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are Plasma membrane estrogen receptor signaling and IGF1 pathway. Affiliated tissues include breast, endothelial and t cells, and related mouse phenotypes are craniofacial and skeleton.

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 468)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis34.4CD68, PTER
2entropion30.5MMP1, MMP9
3odontoma30.5MMP1, MMP9
4rheumatoid arthritis29.6ACP5, CSF1, CSF1R, MMP1
5noonan syndrome 112.0
6noonan syndrome 410.6
7endotheliitis10.5
8leukemia10.5
9pseudoachondroplastic dysplasia 210.4PTPN11, SOS1
10rad21-related cornelia de lange syndrome10.4PTPN11, SOS1
11uterine corpus serous adenocarcinoma10.4PTPN11, SOS1
12childhood central nervous system mature teratoma10.4PTPN11, SOS1
13myocardial infarction10.4
14hepatitis10.4
15cerebritis10.4
16neuronitis10.4
17growth restriction, severe, with distinctive facies10.4PTPN11, SOS1
18hernia of ovary and fallopian tube10.4ACP5, MMP9
19lung cancer10.3
20hepatocellular carcinoma10.3
21breast cancer10.3
22obesity10.3
23lymphoma10.3
24myeloma10.3
25sarcoma10.3
26prostatitis10.3
27melanoma10.3
28cervicitis10.3
29adenocarcinoma10.3
30ganglion or cyst of synovium/tendon/bursa10.3MMP1, MMP9
31conjunctival disease10.3MMP1, MMP9
32grade iii astrocytoma10.3MMP1, MMP9
33flat retinoschisis10.3MMP1, MMP9
34prostate cancer10.3
35asthma10.3
36hydrocephalus10.3
37esophagitis10.3
38hypothyroidism10.3
39candidiasis10.3
40ovarian cancer10.3
41thyroiditis10.3
42lupus erythematosus10.3
43muscular dystrophy10.3
44cervical intraepithelial neoplasia10.3
45aneurysm10.3
46humeroradial synostosis10.3MMP1, SOS1
47spastic diplegia10.3MMP1, MMP9
48common bile duct neoplasm10.3ENO2, MMP9
49acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)10.2CSF1, CSF1R
50agraphia10.2ACP5, PTPN11

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 1, Phase 24477
2AntibodiesPhase 1, Phase 24477
3Grapefruit Seed ExtractNutraceuticalPhase 238

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)RecruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

33
Breast, Endothelial, T cells, Lung, Liver, Skin, Bone

Animal Models for Villonodular Synovitis or affiliated genes

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MGI Mouse Phenotypes related to Villonodular Synovitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.3CSF1, CSF1R, ENO2, PTPN11, SOS1
2MP:00053908.0CD68, CSF1, CSF1R, MMP9, PTPN11, SOS1
3MP:00053877.2CD68, CSF1, CSF1R, MMP1, MMP9, PTPN11

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study. (27106510)
2016
2
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome. (26172944)
2015
3
ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant. (24852373)
2014
4
Incongruities in the AAOMS Position Paper: Medication-Related Osteonecrosis of the Jaw-2014 Update. (25315315)
2014
5
Uteroglobin, a possible ligand of the lipoxin receptor inhibits serum amyloid A-driven inflammation. (24782597)
2014
6
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer. (22806361)
2013
7
Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type. (23459374)
2013
8
Pathogenesis of coxsackievirus B3-induced myocarditis: role of macrophage migration inhibitory factor. (22340465)
2012
9
Intraoperative facial electromyography and brainstem auditory evoked potential findings in microvascular decompression for hemifacial spasm: correlation with postoperative delayed facial palsy. (22777492)
2012
10
Leiomyoma of the female urethra-a rare tumor: case report and review of the literature. (22844631)
2012
11
Polycystic ovary syndrome (PCOS)-like phenotypes in the d-galactose-induced aging mouse model. (23022527)
2012
12
Expression of essential B cell development genes in horses with common variable immunodeficiency. (22464097)
2012
13
Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma. (22227397)
2012
14
Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). (20026779)
2010
15
Association of TGFB1 -509 C>T polymorphism with breast cancer: evidence from a meta-analysis involving 23,579 subjects. (20232138)
2010
16
Involvement of genetic instability in the downregulation of sFRP1 in Chinese patients with hepatocellular carcinoma. (21046672)
2010
17
Hepatoprotective and antioxidant activity of two iridoids from Mussaenda 'dona aurora'. (19678533)
2009
18
Activated partial thromboplastin time and risk of future venous thromboembolism. (18328308)
2008
19
Podoplanin expression in advanced-stage gastric carcinoma and prognostic value of lymphatic microvessel density. (18665758)
2008
20
Leber congenital amaurosis - a model for efficient genetic testing of heterogeneous disorders: LXIV Edward Jackson Memorial Lecture. (17964524)
2007
21
Acute interstitial pneumonia in feedlot cattle: effects of feeding feather meal or vitamin E. (17479779)
2007
22
Mouse Models of Lipodystrophy Key reagents for the understanding of the metabolic syndrome. (18193096)
2007
23
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. (17530208)
2007
24
c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. (17288874)
2007
25
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. (15956025)
2006
26
Anti-oxidant enzyme activities and expression and oxidative damage in patients with non-immediate reactions to drugs. (16879248)
2006
27
PTCH mutations in sporadic and Gorlin-syndrome-related odontogenic keratocysts. (16931872)
2006
28
Evaluation of the degree of clinical rheumatoid arthritis activity based on the concentrations of cytokines TNF-alpha, IL-12, IL-15, and IL-18 in serum and synovial fluid]. (16471244)
2006
29
Differentiation of the human mesenchymal stem cells derived from bone marrow and enhancement of cell attachment by fibronectin. (15901064)
2004
30
Evidence that nuclear factor-kappa B activation is critical in oxidant-induced disruption of the microtubule cytoskeleton and barrier integrity and that its inactivation is essential in epidermal growth factor-mediated protection of the monolayers of intestinal epithelia. (12815011)
2003
31
Drug addiction and HIV infection on rise in Tajikistan. (14570036)
2003
32
Differences in leptin production by regional fat mass in postmenopausal women. (12402972)
2002
33
Effect of N,N'-dinitrosopiperazine on in vitro expression of human cytochrome P450 2E1. (12215299)
2002
34
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (11244486)
2001
35
Interferon-associated retinopathy and cystoid macular edema. (11448335)
2001
36
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
37
Erythromycin use linked to pyloric stenosis. (10738394)
2000
38
In vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene. (10594514)
1999
39
Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis. (9541385)
1998
40
Hyper insulinism and decreased insulin sensitivity in nonobese healthy offspring of conjugal diabetic parents and individuals with IGT and NIDDM. (9062808)
1996
41
Low levels of hepatic cytochrome P-450 in Mexicans with uncomplicated cholelithiasis. (7839018)
1994
42
Elastin in the human posterior longitudinal ligament and spinal dura. A histologic and biochemical study. (7809748)
1994
43
Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women. (8475226)
1993
44
Interstitial irradiation of a large, low grade ependymoma with stereotactically implanted iodine-125 seeds. Case report. (8333303)
1993
45
Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres. (1659383)
1991
46
Glycoprotein Ib bioassays. Activity levels in Bernard-Soulier syndrome and in stored blood bank platelets. (2021317)
1991
47
Simultaneous presentation of rheumatoid arthritis and acute myeloid leukaemia masquerading as Felty's syndrome. (3465419)
1986
48
The relationship between dapsone dose, serum concentration and disease severity in dermatitis herpetiformis. (3954818)
1986
49
SOME MODIFICATIONS IN METHOD OF TREATING TETANUS NEONATORUM WITH INTERMITTENT POSITIVE-PRESSURE RESPIRATION. (14160093)
1964
50

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.8MMP9, SOS1
29.8PTPN11, SOS1
39.8PTPN11, SOS1
4
Show member pathways
9.8PTPN11, SOS1
59.8PTPN11, SOS1
69.8PTPN11, SOS1
79.8PTPN11, SOS1
89.8PTPN11, SOS1
99.7MMP1, MMP9
109.7MMP1, MMP9
119.7MMP1, MMP9
129.5MMP9, PTPN11, SOS1
139.5MMP9, PTPN11, SOS1
149.5MMP9, PTPN11, SOS1
159.4CD68, CSF1
169.4MMP1, MMP9, SOS1
179.4MMP1, MMP9, SOS1
18
Show member pathways
9.4MMP1, PTPN11, SOS1
19
Show member pathways
9.4MMP1, PTPN11, SOS1
20
Show member pathways
9.4MMP1, PTPN11, SOS1
219.2ACP5, CSF1, MMP1
229.2CSF1, CSF1R, PTPN11
239.2CSF1, CSF1R, SOS1
249.2ACP5, CSF1, CSF1R
25
Show member pathways
8.9CSF1, CSF1R, PTPN11, SOS1
268.9CSF1R, MMP1, MMP9, SOS1

GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.1CSF1, CSF1R
2macrophage differentiationGO:003022510.1CSF1, CSF1R
3positive regulation of osteoclast differentiationGO:00456729.9CSF1, CSF1R
4ossificationGO:00015039.7ACP5, CSF1, MMP9
5osteoclast differentiationGO:00303169.7ACP5, CSF1, CSF1R
6dephosphorylationGO:00163119.5ACP5, PTPN11
7innate immune responseGO:00450878.9CSF1, CSF1R, PTPN11, SOS1

Sources for Villonodular Synovitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet