Aliases & Classifications for Villonodular Synovitis

MalaCards integrated aliases for Villonodular Synovitis:

Name: Villonodular Synovitis 12 14 69
Pigmented Villonodular Synovitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD10 32 M12.20 M12.2
ICD9CM 34 719.2 719.20
UMLS 69 C0158168

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to pigmented villonodular synovitis and giant cell tumor, and has symptoms including stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint and arthralgia. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and MicroRNAs in cancer. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Villonodular synovitis is a type of synovial... more...

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 pigmented villonodular synovitis 33.0 ACP5 MMP9 PTPN11 TNFSF11
2 giant cell tumor 30.2 MMP9 TNFSF11 VIM
3 bone giant cell tumor 29.9 ACP5 VIM
4 osteonecrosis 29.7 ACP5 TNFSF11
5 noonan syndrome 1 12.0
6 synovitis 11.3
7 noonan syndrome 4 11.2
8 tenosynovial giant cell tumor 10.4
9 episodic pain syndrome, familial, 1 10.4
10 arthritis 10.3
11 rheumatoid arthritis 10.3
12 synovial chondromatosis 10.3
13 pulmonary valve stenosis 10.2 PTPN11 SOS1
14 pulmonary valve disease 10.2 PTPN11 SOS1
15 costello syndrome 10.2 PTPN11 SOS1
16 cardiofaciocutaneous syndrome 1 10.2 PTPN11 SOS1
17 popliteal cyst 10.1
18 mycobacterium tuberculosis 1 10.1
19 sarcoma 10.1
20 malignant giant cell tumor 10.1
21 synovium cancer 10.1
22 neuropathy 10.1
23 gingival hypertrophy 10.1 MMP9 VIM
24 fibromatosis 10.1 SOS1 VIM
25 odontogenic myxoma 10.1 MMP9 VIM
26 enchondromatosis, multiple, ollier type 10.1 ACP5 PTPN11
27 carpal tunnel syndrome 10.1
28 mononeuropathy of the median nerve, mild 10.1
29 osteoarthritis 10.1
30 hemarthrosis 10.1
31 hypercementosis 10.0 ACP5 MMP9
32 pneumothorax 10.0 MMP9 VIM
33 spondyloarthropathy 1 9.9
34 lipomatosis, multiple 9.9
35 systemic lupus erythematosus 9.9
36 chediak-higashi syndrome 9.9
37 sarcoma, synovial 9.9
38 osteoarthritis with mild chondrodysplasia 9.9
39 tendinitis 9.9
40 hemangioma 9.9
41 lymphoma 9.9
42 inflammatory spondylopathy 9.9
43 squamous cell carcinoma 9.9
44 melanoma 9.9
45 cervicitis 9.9
46 chondroblastoma 9.9
47 nodular tenosynovitis 9.9
48 malignant giant cell tumor of the tendon sheath 9.9
49 peroneal neuropathy 9.9
50 ulnar neuropathy 9.9

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, arthralgia, pain

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.47 VIM
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.47 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.47 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.47 SOS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.47 SOS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.47 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 SOS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.47 SOS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 SOS1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 VIM SOS1 TNFSF11
13 Decreased cell migration GR00055-A-1 9.33 VIM ACP5 SOS1
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 VIM ACP5 PTPN11

MGI Mouse Phenotypes related to Villonodular Synovitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.55 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 respiratory system MP:0005388 9.26 VIM MMP9 PTPN11 TNFSF11
3 vision/eye MP:0005391 9.02 VIM MMP9 PTPN11 SOS1 TNFSF11

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1, Phase 2
2 Antibodies Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 1
6 Antimitotic Agents Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2 FPA008
4 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

38
Bone, Testes, Lung

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 618)
# Title Authors Year
1
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
2
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
3
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
4
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
5
Total knee replacement in patients with diffuse villonodular synovitis. ( 29062829 )
2017
6
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
7
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
8
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
9
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
10
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
11
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
12
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
13
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
14
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
15
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
16
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
17
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
18
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
19
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
20
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
21
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
22
Pigmented Villonodular Synovitis of the Temporomandibular Joint With Petrous Bone Invasion. ( 28333775 )
2017
23
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
24
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
25
All-Arthroscopic Treatment of Intra- and Extra-Articular Localized Villonodular Synovitis of Knee. ( 29270551 )
2017
26
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis. ( 28764182 )
2017
27
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
28
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
29
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
30
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
31
Pigmented villonodular synovitis of the hip. ( 28461957 )
2016
32
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016
33
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report. ( 28824995 )
2016
34
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. ( 27462929 )
2016
35
Villonodular synovitis of the ankle. Analysis of the risk of recurrence. ( 27197681 )
2016
36
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
37
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. ( 28032093 )
2016
38
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
39
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
40
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. ( 27200236 )
2016
41
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
42
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. ( 26919624 )
2016
43
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
44
Villonodular synovitis shoulder complicated by rotator cuff rupture. ( 27068614 )
2016
45
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. ( 27190776 )
2016
46
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
47
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. ( 26810732 )
2016
48
Multifocal pigmented villonodular synovitis in a child: A case report. ( 27537585 )
2016
49
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
50
Pigmented villonodular synovitis of the temporomandibular joint: Case report and review of literature. ( 25821131 )
2015

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 12.2 MMP9 SOS1 VIM
3
Show member pathways
12.15 PTPN11 SOS1 TNFSF11
4
Show member pathways
12.08 PTPN11 SOS1 VIM
5
Show member pathways
11.86 PTPN11 SOS1 TNFSF11
6 11.81 MMP9 PTPN11 SOS1
7
Show member pathways
11.58 PTPN11 SOS1
8 11.57 ACP5 TNFSF11
9 11.49 MMP9 PTPN11
10
Show member pathways
11.42 PTPN11 SOS1
11
Show member pathways
11.38 PTPN11 SOS1
12 11.32 PTPN11 SOS1
13 11.28 PTPN11 SOS1
14 11.21 PTPN11 SOS1
15 11.19 PTPN11 SOS1
16 11.12 PTPN11 SOS1
17
Show member pathways
11.07 PTPN11 SOS1 TNFSF11
18 11.03 PTPN11 SOS1
19
Show member pathways
10.95 PTPN11 SOS1
20 10.9 PTPN11 SOS1
21 10.82 MMP9 SOS1
22 10.77 PTPN11 SOS1
23 10.47 MMP9 PTPN11 SOS1
24 10.46 ACP5 TNFSF11

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.46 MMP9 TNFSF11
2 ephrin receptor signaling pathway GO:0048013 9.43 MMP9 PTPN11
3 leukocyte migration GO:0050900 9.43 MMP9 PTPN11 SOS1
4 multicellular organism growth GO:0035264 9.4 PTPN11 SOS1
5 epidermal growth factor receptor signaling pathway GO:0007173 9.37 PTPN11 SOS1
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.32 MMP9 SOS1
7 bone resorption GO:0045453 9.16 ACP5 TNFSF11
8 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 PTPN11 SOS1
9 Bergmann glial cell differentiation GO:0060020 8.62 PTPN11 VIM

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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