MCID: VLL003
MIFTS: 53

Villonodular Synovitis malady

Bone diseases category

Summaries for Villonodular Synovitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Villonodular synovitis is a type of synovial swelling. more...

MalaCards: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Syndecan-1-mediated signaling events and Osteopontin Signaling. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Aliases & Classifications for Villonodular Synovitis

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63UMLS, 9Disease Ontology, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

villonodular synovitis 9
pigmented villonodular synovitis 63


External Ids:

Disease Ontology9 DOID:9898
ICD9CM28 719.20, 719.2
ICD1026 M12.2

Related Diseases for Villonodular Synovitis

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18GeneCards, 19GeneDecks
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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.4TNFSF11, TNFRSF11B, MMP1, CD68
2pigmented villonodular synovitis32.2CSF1, CSF1R, MOAP1, ANKLE2, ATP6V1B2, LAPTM5
3giant cell tumor31.3TNFSF11, CSF1, CSF1R
4osteonecrosis30.7BGLAP
5arthritis30.6CSF1R, MMP1, MMP9, TNFRSF11B, CSF1, TNFSF11
6rheumatoid arthritis30.5MMP9, CD68, ACP5, CSF1, TNFRSF11B, IBSP
7osteoarthritis29.8TNFRSF11B, SPP1, BGLAP, IBSP, TNFSF11, PTHLH
8melanoma29.8CD68, PCNA, SPP1, IBSP, TNFSF11, TNFRSF11B
9tenosynovial giant cell tumor10.7
10synovial chondromatosis10.5
11malignant giant cell tumor10.4
12neuropathy10.4
13hemarthrosis10.3
14carpal tunnel syndrome10.3
15tuberculosis10.3
16tendinitis10.2
17malignant giant cell tumor of the tendon sheath10.2
18nodular tenosynovitis10.2
19chondroblastoma10.2
20peroneal neuropathy10.2
21ulnar neuropathy10.2
22noonan syndrome10.2
23systemic lupus erythematosus10.2
24bone giant cell tumor10.2
25cervicitis10.2
26conjunctivitis10.2
27hemangioma10.2
28lipoma10.2
29lupus erythematosus10.2
30paraplegia10.2
31sarcoma10.2
32noonan-like/multiple giant cell lesion syndrome10.2
33soft tissue sarcoma10.2
34spastic paraparesis10.2
35spasticity10.2
36polyploidy10.2
37multicentric reticulohistiocytosis10.1CD68
38camurati-engelmann disease10.1BGLAP
39cherubism10.1TNFSF11
40periapical granuloma10.1TNFSF11
41pseudohypoparathyroidism type 1b10.1BGLAP, PTHLH
42fibrous dysplasia10.1IBSP, BGLAP
43osteopetrosis autosomal dominant type 210.1TNFSF11, BGLAP
44paget disease, juvenile10.1TNFRSF11B, TNFSF11
45pseudohypoparathyroidism10.1BGLAP, PTHLH
46polyostotic osteolytic dysplasia, hereditary expansile10.1TNFSF11, TNFRSF11B
47osteomyelitis10.1ACP5, IBSP, TNFSF11
48osteosclerosis10.1TNFSF11, TNFRSF11B
49dentin dysplasia10.1IBSP, SPP1
50dentinogenesis imperfecta10.1SPP1, IBSP

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Villonodular Synovitis

Drug clinical trials:

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Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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34MalaCards
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MalaCards organs/tissues related to Villonodular Synovitis:

34
Bone, Lung, Testes

Animal Models for Villonodular Synovitis or affiliated genes

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38MGI
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Publications for Villonodular Synovitis

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53PubMed
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Articles related to Villonodular Synovitis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
2
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
3
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
4
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
5
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
6
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
7
Pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. (21310347)
2011
8
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
9
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
10
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
11
Pigmented villonodular synovitis of the elbow in a 6-year-old girl: a case report. (17429130)
2007
12
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
13
Pigmented villonodular synovitis. (16311109)
2006
14
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
15
Clustered localized pigmented villonodular synovitis. (15944639)
2005
16
Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. (16012505)
2005
17
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
18
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
19
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
20
Pigmented villonodular synovitis of the knee presenting as sciatica. (12943290)
2003
21
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
22
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
23
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
24
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
25
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
26
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
27
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
28
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
29
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
30
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
31
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
32
Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings. (9888766)
1999
33
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
34
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
35
Radiographic diagnosis--canine carpal villonodular synovitis. (9491512)
1998
36
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
37
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
38
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
39
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
40
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
41
Evaluation of the hip with pigmented villonodular synovitis. A case report. (1735210)
1992
42
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
43
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
44
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
45
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
46
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
47
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
48
Lipid microspherules in synovial fluid of patients with pigmented villonodular synovitis. (3190786)
1988
49
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 56Reactome, 31KEGG
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Pathways related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP9, MMP1
29.8SPP1, MMP9
3
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.8ACP5, TNFRSF11B, TNFSF11
49.7CD68, CSF1
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.6MMP9, TNFRSF11B, TNFSF11
69.6MMP1, MMP9, BGLAP
79.6CSF1, CSF1R, SPP1
89.6MMP9, PTHLH, SPP1
99.6SPP1, BGLAP, MMP9
109.5PDGFRB, CSF1, CSF1R
119.5CSF1R, CSF1, PDGFRB
129.5SPP1, TNFSF11, TNFRSF11B, ACP5
139.4TNFRSF11B, TNFSF11, BGLAP, SPP1
149.4IBSP, TNFSF11, TNFRSF11B, PDGFRB
15
Show member pathways
9.3SPP1, IBSP, MMP9, MMP1
169.3LAPTM5, ACP5, CD68
179.3PTHLH, TNFSF11, IBSP, BGLAP, SPP1
189.2PDGFRB, CSF1R, MMP1, MMP9
199.2TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
20
Show member pathways
9.0TNFSF11, TNFRSF11B, CSF1R, CSF1, PDGFRB
219.0SPP1, IBSP, CSF1R, CSF1, PDGFRB
22
Show member pathways
9.0PDGFRB, CSF1, CSF1R, TNFSF11, SPP1
238.6CSF1, ACP5, MMP1, TNFSF11, ATP6V1B2

Compounds for genes affiliated with Villonodular Synovitis

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1pyridinoline4610.6TNFRSF11B
2ibandronate46 1210.8TNFRSF11B, IBSP, BGLAP, TNFSF11
3deoxypyridinoline469.7TNFSF11, IBSP, ACP5, BGLAP, TNFRSF11B
4tartrate469.6CSF1, PTHLH, TNFSF11, BGLAP, ACP5
5pamidronate46 52 1211.6BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
6alendronate46 52 1211.5PTHLH, TNFRSF11B, TNFSF11, MMP1, BGLAP
7vitamin k2469.5BGLAP, TNFSF11, TNFRSF11B, CSF1
8clodronate46 52 1211.5MMP1, TNFSF11, TNFRSF11B, PTHLH, BGLAP, ACP5
9titanium469.4SPP1, IBSP, ACP5, TNFRSF11B, TNFSF11, BGLAP
1025-hydroxyvitamin d469.4PTHLH, TNFSF11, TNFRSF11B, ACP5, BGLAP, SPP1
11phosphorus469.4BGLAP, PTHLH, SPP1, TNFSF11, ACP5, TNFRSF11B
12infliximab46 52 1211.4MMP1, TNFRSF11B, BGLAP, SPP1, TNFSF11
13hydroxyapatite469.2IBSP, TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH
14hydroxyproline46 25 1211.1ACP5, MMP9, PTHLH, TNFRSF11B, IBSP, MMP1
15zoledronic acid469.1BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9
16azathioprine46 3 52 1212.1PCNA, PTHLH, TNFRSF11B, BGLAP, TNFSF11, ACP5
17geranylgeranyl pyrophosphate469.0TNFRSF11B, MMP9, MMP1, TNFSF11
18celecoxib46 62 30 52 25 1213.8TNFSF11, TNFRSF11B, MMP9, MMP1, PCNA, CSF1
19prostaglandin468.8PTHLH, MMP9, MMP1, CSF1, TNFRSF11B, TNFSF11
20tgf beta1468.8PTHLH, SPP1, TNFRSF11B, MMP1, CSF1, PDGFRB
21matrigel468.7IBSP, SPP1, PTHLH, MMP9, PDGFRB, MMP1
22rantes468.7MMP1, MMP9, TNFRSF11B, TNFSF11, CSF1, ACP5
23ns 39846 629.7BGLAP, TNFSF11, TNFRSF11B, MMP9, PCNA, MMP1
241,25 dihydroxy vitamin d3468.7CSF1, CSF1R, ACP5, PTHLH, TNFRSF11B, TNFSF11
25estradiol46 25 1210.7IBSP, ACP5, MMP1, TNFRSF11B, TNFSF11, PTHLH
26pd 98,059468.7CSF1, CSF1R, MMP9, TNFSF11, IBSP, MMP1
27vitamin d468.6BGLAP, SPP1, CSF1R, TNFSF11, IBSP, PTHLH
28indomethacin46 30 62 1211.6SPP1, TNFSF11, PTHLH, CSF1, TNFRSF11B, PCNA
29nicotine46 30 52 1211.5MMP1, PTHLH, CSF1, SPP1, PCNA, MMP9
30calcitriol46 62 25 1211.5TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
31ascorbic acid46 259.5SPP1, CSF1, BGLAP, IBSP, TNFRSF11B, MMP1
32cyclosporin a46 30 6210.4TNFRSF11B, BGLAP, SPP1, TNFSF11, MMP9, MMP1
33cycloheximide468.4SPP1, MMP9, TNFRSF11B, TNFSF11, MMP1, IBSP
34heparin46 30 25 1211.3PTHLH, BGLAP, TNFSF11, IBSP, SPP1, TNFRSF11B
35procollagen468.3SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PCNA
36phosphatidylinositol468.2IBSP, SPP1, TNFRSF11B, PTHLH, TNFSF11, CSF1R
37progesterone46 30 62 25 1212.2SPP1, TNFRSF11B, PTHLH, MMP1, CSF1R, CSF1
38genistein46 30 62 3 25 1213.2PCNA, MMP9, SPP1, PDGFRB, TNFSF11, MMP1
39h2o2468.2TNFSF11, PDGFRB, MMP1, BGLAP, SPP1, CSF1
40pge2468.0TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1, ACP5
41testosterone46 62 25 1210.8CSF1, TNFRSF11B, TNFSF11, PTHLH, MMP9, BGLAP
42creatinine467.8CSF1, PCNA, ACP5, MMP1, MMP9, PTHLH
43tyrosine467.7CSF1, CSF1R, ACP5, MMP9, PTHLH, TNFRSF11B
44serine467.7TNFRSF11B, IBSP, BGLAP, SPP1, PTHLH, MMP9
45retinoic acid46 258.7CSF1R, PDGFRB, CSF1, PCNA, TNFRSF11B, MMP1
46dexamethasone46 52 30 1210.5CSF1, CSF1R, PCNA, ACP5, MMP1, MMP9
47vegf467.3IBSP, BGLAP, SPP1, TNFSF11, TNFRSF11B, PTHLH
48cysteine467.3CSF1R, TNFSF11, PDGFRB, TNFRSF11B, IBSP, BGLAP
49estrogen467.1IBSP, PDGFRB, CSF1, PTHLH, SPP1, BGLAP
50paraffin466.9ACP5, MMP1, MMP9, TNFSF11, IBSP, BGLAP

GO Terms for genes affiliated with Villonodular Synovitis

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17Gene Ontology
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Cellular components related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.9BGLAP, SPP1
2extracellular regionGO:0055768.3MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
3extracellular spaceGO:0056158.2SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of bone resorptionGO:04512410.2CSF1R, BGLAP
2osteoclast proliferationGO:00215810.2TNFSF11, CSF1
3positive regulation of bone resorptionGO:04578010.1TNFSF11, SPP1
4response to vitamin DGO:03328010.1BGLAP, SPP1
5phosphatidylinositol metabolic processGO:04648810.1PDGFRB, CSF1R
6biomineral tissue developmentGO:03121410.0IBSP, SPP1
7osteoclast differentiationGO:0303169.9CSF1, CSF1R, TNFSF11
8osteoblast developmentGO:0020769.9BGLAP, PTHLH
9positive regulation of osteoclast differentiationGO:0456729.9TNFSF11, CSF1
10macrophage differentiationGO:0302259.8MMP9, CSF1R, CSF1
11extracellular matrix disassemblyGO:0226179.7SPP1, MMP9, MMP1
12bone resorptionGO:0454539.7ACP5, TNFSF11
13skeletal system developmentGO:0015019.7MMP9, PTHLH, TNFRSF11B, BGLAP
14positive regulation of cell migrationGO:0303359.7CSF1R, CSF1, PDGFRB
15ossificationGO:0015039.6CSF1, MMP9, TNFSF11, IBSP
16phosphatidylinositol-mediated signalingGO:0480159.5PDGFRB, CSF1R, PCNA
17positive regulation of cell proliferationGO:0082849.4PTHLH, CSF1R, CSF1, PDGFRB
18extracellular matrix organizationGO:0301989.4SPP1, IBSP, TNFRSF11B, MMP9, MMP1

Molecular functions related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Villonodular Synovitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Villonodular Synovitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet