MCID: VLL003
MIFTS: 54

Villonodular Synovitis malady

Bone diseases category
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Summaries for Villonodular Synovitis

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Wikipedia:65 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Syndecan-1-mediated signaling events and Osteopontin Signaling. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Aliases & Classifications for Villonodular Synovitis

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Villonodular Synovitis, Aliases & Descriptions:

Name: Villonodular Synovitis 8
 
Pigmented Villonodular Synovitis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:9898
ICD9CM27 719.20, 719.2
ICD1025 M12.2

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.5CD68, MMP1, TNFRSF11B, TNFSF11
2pigmented villonodular synovitis31.7PDGFRB, CSF1, CSF1R, MOAP1, ANKLE2, LAPTM5
3giant cell tumor31.5TNFSF11, CSF1R, CSF1
4osteonecrosis31.3BGLAP
5ankylosing spondylitis30.7TNFRSF11B, TNFSF11, BGLAP
6arthritis29.8BGLAP, TNFSF11, TNFRSF11B, MMP9, MMP1, ACP5
7rheumatoid arthritis29.4TNFSF11, IBSP, BGLAP, SPP1, TNFRSF11B, MMP9
8osteoarthritis28.4MMP1, MMP9, PTHLH, TNFRSF11B, TNFSF11, IBSP
9melanoma28.2SPP1, IBSP, TNFSF11, TNFRSF11B, MMP9, MMP1
10tenosynovial giant cell tumor10.7
11multicentric reticulohistiocytosis10.6CD68
12histiocytosis10.6CD68
13camurati-engelmann disease10.5BGLAP
14synovial chondromatosis10.5
15malignant giant cell tumor10.4
16neuropathy10.4
17cherubism10.4TNFSF11
18periapical granuloma10.4TNFSF11
19pseudohypoparathyroidism type 1b10.4PTHLH, BGLAP
20osteopetrosis autosomal dominant type 210.4BGLAP, TNFSF11
21fibrous dysplasia10.4IBSP, BGLAP
22paget disease, juvenile10.4TNFSF11, TNFRSF11B
23polyostotic osteolytic dysplasia, hereditary expansile10.4TNFSF11, TNFRSF11B
24pseudohypoparathyroidism10.4PTHLH, BGLAP
25hemarthrosis10.4
26carpal tunnel syndrome10.4
27tuberculosis10.4
28osteomyelitis10.3IBSP, TNFSF11, ACP5
29osteosclerosis10.3TNFRSF11B, TNFSF11
30dentin dysplasia10.3SPP1, IBSP
31nephrolithiasis10.3IBSP, SPP1
32dentinogenesis imperfecta10.3SPP1, IBSP
33langerhans-cell histiocytosis10.3CSF1, CD68
34renal osteodystrophy10.3BGLAP, TNFRSF11B, ACP5
35osteofibrous dysplasia10.3BGLAP, SPP1
36fibromatosis10.3PDGFRB
37osteomalacia10.3PTHLH, TNFRSF11B, BGLAP
38malignant histiocytosis10.3CSF1, CSF1R
39hypophosphatemia10.3PTHLH, BGLAP
40acute myelomonocytic leukemia10.3CSF1R, CSF1
41primary hyperparathyroidism10.3BGLAP, IBSP, PTHLH, ACP5
42hypoparathyroidism10.3PTHLH, BGLAP
43beta thalassemia10.2TNFSF11, TNFRSF11B
44rheumatic disease10.2BGLAP, TNFSF11, TNFRSF11B
45gaucher's disease10.2ACP5, BGLAP
46hyperphosphatemia10.2SPP1, TNFRSF11B
47tendinitis10.2
48hemangioma10.2
49systemic lupus erythematosus10.2
50malignant giant cell tumor of the tendon sheath10.2

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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Drug clinical trials:

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Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

32
Bone, Lung, Testes

Animal Models for Villonodular Synovitis or affiliated genes

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Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
2
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
3
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
4
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
5
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
6
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
7
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
8
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
9
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
10
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
11
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
12
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
13
Pigmented villonodular synovitis of the elbow in a 6-year-old girl: a case report. (17429130)
2007
14
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
15
Pigmented villonodular synovitis. (16311109)
2006
16
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
17
Clustered localized pigmented villonodular synovitis. (15944639)
2005
18
Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. (16012505)
2005
19
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
20
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
21
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
22
Pigmented villonodular synovitis of the knee presenting as sciatica. (12943290)
2003
23
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
24
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
25
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
26
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
27
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
28
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
29
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
30
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
31
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
32
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
33
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
34
Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings. (9888766)
1999
35
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
36
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
37
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
38
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
39
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
40
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
41
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
42
Evaluation of the hip with pigmented villonodular synovitis. A case report. (1735210)
1992
43
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
44
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
45
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
46
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
47
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
48
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
49
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Expression patterns in normal tissues for genes affiliated with Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP1, MMP9
29.8MMP9, SPP1
3
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling60
9.8TNFRSF11B, ACP5, TNFSF11
49.7CSF1, CD68
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.6TNFSF11, MMP9, TNFRSF11B
69.6MMP1, MMP9, BGLAP
79.6SPP1, CSF1, CSF1R
89.6PTHLH, MMP9, SPP1
99.6SPP1, MMP9, BGLAP
109.5PDGFRB, CSF1, CSF1R
119.5CSF1R, PDGFRB, CSF1
129.5SPP1, TNFRSF11B, TNFSF11, ACP5
139.4BGLAP, SPP1, TNFRSF11B, TNFSF11
149.4TNFRSF11B, TNFSF11, IBSP, PDGFRB
15
Show member pathways
9.3IBSP, SPP1, MMP9, MMP1
169.3LAPTM5, ACP5, CD68
179.3PTHLH, TNFSF11, IBSP, BGLAP, SPP1
189.2CSF1R, MMP1, MMP9, PDGFRB
199.2TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
20
Show member pathways
9.0TNFSF11, PDGFRB, CSF1, CSF1R, TNFRSF11B
219.0CSF1, CSF1R, IBSP, PDGFRB, SPP1
22
Show member pathways
9.0CSF1, PDGFRB, CSF1R, TNFSF11, SPP1
238.6CSF1, ATP6V1B2, TNFSF11, MMP1, ACP5

Compounds for genes affiliated with Villonodular Synovitis

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Compounds related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1pyridinoline4410.6TNFRSF11B
2ibandronate44 1110.8TNFRSF11B, IBSP, BGLAP, TNFSF11
3deoxypyridinoline449.7TNFSF11, IBSP, ACP5, BGLAP, TNFRSF11B
4tartrate449.6CSF1, PTHLH, TNFSF11, BGLAP, ACP5
5pamidronate44 50 1111.6BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
6alendronate44 50 1111.5PTHLH, TNFRSF11B, TNFSF11, MMP1, BGLAP
7vitamin k2449.5BGLAP, TNFSF11, TNFRSF11B, CSF1
8clodronate44 50 1111.5MMP1, TNFSF11, TNFRSF11B, PTHLH, BGLAP, ACP5
9titanium449.4SPP1, IBSP, ACP5, TNFRSF11B, TNFSF11, BGLAP
1025-hydroxyvitamin d449.4PTHLH, TNFSF11, TNFRSF11B, ACP5, BGLAP, SPP1
11phosphorus449.4BGLAP, PTHLH, SPP1, TNFSF11, ACP5, TNFRSF11B
12infliximab44 50 1111.4MMP1, TNFRSF11B, BGLAP, SPP1, TNFSF11
13hydroxyapatite449.2IBSP, TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH
14hydroxyproline44 24 1111.1ACP5, MMP9, PTHLH, TNFRSF11B, IBSP, MMP1
15zoledronic acid449.1BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9
16azathioprine44 2 50 1112.1PCNA, PTHLH, TNFRSF11B, BGLAP, TNFSF11, ACP5
17geranylgeranyl pyrophosphate449.0TNFRSF11B, MMP9, MMP1, TNFSF11
18celecoxib44 61 28 50 24 1113.8TNFSF11, TNFRSF11B, MMP9, MMP1, PCNA, CSF1
19prostaglandin448.8PTHLH, MMP9, MMP1, CSF1, TNFRSF11B, TNFSF11
20tgf beta1448.8PTHLH, SPP1, TNFRSF11B, MMP1, CSF1, PDGFRB
21matrigel448.7IBSP, SPP1, PTHLH, MMP9, PDGFRB, MMP1
22rantes448.7MMP1, MMP9, TNFRSF11B, TNFSF11, CSF1, ACP5
23ns 39844 619.7BGLAP, TNFSF11, TNFRSF11B, MMP9, PCNA, MMP1
241,25 dihydroxy vitamin d3448.7CSF1, CSF1R, ACP5, PTHLH, TNFRSF11B, TNFSF11
25estradiol44 24 1110.7IBSP, ACP5, MMP1, TNFRSF11B, TNFSF11, PTHLH
26pd 98,059448.7CSF1, CSF1R, MMP9, TNFSF11, IBSP, MMP1
27vitamin d448.6BGLAP, SPP1, CSF1R, TNFSF11, IBSP, PTHLH
28indomethacin44 28 61 1111.6SPP1, TNFSF11, PTHLH, CSF1, TNFRSF11B, PCNA
29nicotine44 28 50 1111.5MMP1, PTHLH, CSF1, SPP1, PCNA, MMP9
30calcitriol44 61 24 1111.5TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
31ascorbic acid44 249.5SPP1, CSF1, BGLAP, IBSP, TNFRSF11B, MMP1
32cyclosporin a44 28 6110.4TNFRSF11B, BGLAP, SPP1, TNFSF11, MMP9, MMP1
33cycloheximide448.4SPP1, MMP9, TNFRSF11B, TNFSF11, MMP1, IBSP
34heparin44 28 24 1111.3PTHLH, BGLAP, TNFSF11, IBSP, SPP1, TNFRSF11B
35procollagen448.3SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PCNA
36phosphatidylinositol448.2IBSP, SPP1, TNFRSF11B, PTHLH, TNFSF11, CSF1R
37progesterone44 28 61 24 1112.2SPP1, TNFRSF11B, PTHLH, MMP1, CSF1R, CSF1
38genistein44 28 61 2 24 1113.2PCNA, MMP9, SPP1, PDGFRB, TNFSF11, MMP1
39h2o2448.2TNFSF11, PDGFRB, MMP1, BGLAP, SPP1, CSF1
40pge2448.0TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1, ACP5
41testosterone44 61 24 1110.8CSF1, TNFRSF11B, TNFSF11, PTHLH, MMP9, BGLAP
42creatinine447.8CSF1, PCNA, ACP5, MMP1, MMP9, PTHLH
43tyrosine447.7CSF1, CSF1R, ACP5, MMP9, PTHLH, TNFRSF11B
44serine447.7TNFRSF11B, IBSP, BGLAP, SPP1, PTHLH, MMP9
45retinoic acid44 248.7CSF1R, PDGFRB, CSF1, PCNA, TNFRSF11B, MMP1
46dexamethasone44 50 28 1110.5CSF1, CSF1R, PCNA, ACP5, MMP1, MMP9
47vegf447.3IBSP, BGLAP, SPP1, TNFSF11, TNFRSF11B, PTHLH
48cysteine447.3CSF1R, TNFSF11, PDGFRB, TNFRSF11B, IBSP, BGLAP
49estrogen447.1IBSP, PDGFRB, CSF1, PTHLH, SPP1, BGLAP
50paraffin446.9ACP5, MMP1, MMP9, TNFSF11, IBSP, BGLAP

GO Terms for genes affiliated with Villonodular Synovitis

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Cellular components related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.9BGLAP, SPP1
2extracellular regionGO:0055768.3MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
3extracellular spaceGO:0056158.2SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of bone resorptionGO:04512410.2CSF1R, BGLAP
2osteoclast proliferationGO:00215810.2CSF1, TNFSF11
3positive regulation of bone resorptionGO:04578010.1TNFSF11, SPP1
4response to vitamin DGO:03328010.1BGLAP, SPP1
5phosphatidylinositol metabolic processGO:04648810.1PDGFRB, CSF1R
6osteoblast developmentGO:00207610.0BGLAP, PTHLH
7biomineral tissue developmentGO:03121410.0SPP1, IBSP
8osteoclast differentiationGO:0303169.9CSF1, CSF1R, TNFSF11
9macrophage differentiationGO:0302259.8CSF1, MMP9, CSF1R
10positive regulation of osteoclast differentiationGO:0456729.8TNFSF11, CSF1
11extracellular matrix disassemblyGO:0226179.7SPP1, MMP9, MMP1
12bone resorptionGO:0454539.7TNFSF11, ACP5
13skeletal system developmentGO:0015019.7MMP9, BGLAP, TNFRSF11B, PTHLH
14positive regulation of cell migrationGO:0303359.7PDGFRB, CSF1, CSF1R
15ossificationGO:0015039.6TNFSF11, IBSP, CSF1, MMP9
16phosphatidylinositol-mediated signalingGO:0480159.5PDGFRB, CSF1R, PCNA
17positive regulation of cell proliferationGO:0082849.4CSF1R, CSF1, PDGFRB, PTHLH
18extracellular matrix organizationGO:0301989.4MMP9, TNFRSF11B, IBSP, SPP1, MMP1

Molecular functions related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Villonodular Synovitis

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Sources for Villonodular Synovitis

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3CDC
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25ICD10
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