Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 10 12 65
 
Pigmented Villonodular Synovitis 65

Classifications:



External Ids:

Disease Ontology10 DOID:9898
ICD1027 M12.20, M12.2
ICD9CM29 719.2, 719.20
UMLS65 C0158168

Summaries for Villonodular Synovitis

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Wikipedia:68 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to pigmented villonodular synovitis and synovitis, and has symptoms including stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint and arthralgia. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are Plasma membrane estrogen receptor signaling and IGF1 pathway. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are craniofacial and skeleton.

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis34.0CD68, PTER
2synovitis30.4ACP5, CSF1, CSF1R, MMP1, MMP9, PTPN11
3rheumatoid arthritis29.8ACP5, CSF1, CSF1R, MMP1
4noonan syndrome 111.6
5pseudoachondroplastic dysplasia 210.7PTPN11, SOS1
6rad21-related cornelia de lange syndrome10.7PTPN11, SOS1
7uterine corpus serous adenocarcinoma10.6PTPN11, SOS1
8childhood central nervous system mature teratoma10.6PTPN11, SOS1
9giant cell tumor10.6
10growth restriction, severe, with distinctive facies10.5PTPN11, SOS1
11hernia of ovary and fallopian tube10.5ACP5, MMP9
12entropion10.5MMP1, MMP9
13ganglion or cyst of synovium/tendon/bursa10.5MMP1, MMP9
14conjunctival disease10.5MMP1, MMP9
15tenosynovial giant cell tumor10.5
16grade iii astrocytoma10.5MMP1, MMP9
17odontoma10.4MMP1, MMP9
18flat retinoschisis10.4MMP1, MMP9
19humeroradial synostosis10.4MMP1, SOS1
20spastic diplegia10.4MMP1, MMP9
21common bile duct neoplasm10.4ENO2, MMP9
22acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)10.4CSF1, CSF1R
23agraphia10.4ACP5, PTPN11
24arthritis10.4
25scleredema adultorum10.4CSF1, CSF1R
26cystic echinococcosis10.3MMP1, SOS1
27septicemic plague10.3CD68, MMP9
28acute vascular insufficiency of intestine10.3CSF1, CSF1R
29rete testis neoplasm10.3ACP5, CD68
30hydranencephaly10.3ACP5, PTPN11
31abnormal pupillary function10.3MMP1, MMP9
32gastrointestinal carcinoma10.3CD68, MMP9
33synovial chondromatosis10.3
34dentine erosion10.2CD68, MMP9
35noonan syndrome 410.2
36staphyloenterotoxemia10.2ACP5, CD68
37umbilical hernia10.2MMP1, MMP9
38sarcoma10.2
39malignant giant cell tumor10.2
40tuberculosis10.2
41neuropathy10.2
42otosalpingitis10.2ACP5, CSF1, MMP9
43progressive relapsing multiple sclerosis10.2CSF1R, MMP9
44extrahepatic bile duct lipoma10.1CD68, ENO2
45pediatric fibrosarcoma10.1CD68, ENO2
46osteonecrosis10.1
47hemarthrosis10.1
48atypical polypoid adenomyoma10.1CD68, ENO2
49uterine corpus adenocarcinofibroma10.1CD68, ENO2
50integumentary system cancer10.1CD68, ENO2

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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UMLS symptoms related to Villonodular Synovitis:


stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, arthralgia, pain

Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 1, Phase 24477
2AntibodiesPhase 1, Phase 24477
3Grapefruit Seed ExtractNutraceuticalPhase 238

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)RecruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

33
Bone, Breast, Lung, Liver, Myeloid, B cells, Brain

Animal Models for Villonodular Synovitis or affiliated genes

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MGI Mouse Phenotypes related to Villonodular Synovitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.3CSF1, CSF1R, ENO2, PTPN11, SOS1
2MP:00053908.0CD68, CSF1, CSF1R, MMP9, PTPN11, SOS1
3MP:00053877.2CD68, CSF1, CSF1R, MMP1, MMP9, PTPN11

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. (26219971)
2015
2
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
3
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
4
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. (26440548)
2015
5
Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells. (26499059)
2015
6
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
7
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
8
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
9
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
10
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
11
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
12
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
13
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
14
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
15
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
16
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
17
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
18
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
19
Pigmented villonodular synovitis. (16311109)
2006
20
Clustered localized pigmented villonodular synovitis. (15944639)
2005
21
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
22
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
23
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
24
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
25
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
26
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
27
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
28
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
29
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
30
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
31
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
32
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
33
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
34
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
35
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
36
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
37
Radiographic diagnosis--canine carpal villonodular synovitis. (9491512)
1998
38
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
39
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
40
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
41
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
42
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
43
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
44
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
45
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
46
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
47
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982
50

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.8MMP9, SOS1
29.8PTPN11, SOS1
39.8PTPN11, SOS1
4
Show member pathways
9.8PTPN11, SOS1
59.8PTPN11, SOS1
69.8PTPN11, SOS1
79.8PTPN11, SOS1
89.8PTPN11, SOS1
99.7MMP1, MMP9
109.7MMP1, MMP9
119.7MMP1, MMP9
129.5MMP9, PTPN11, SOS1
139.5MMP9, PTPN11, SOS1
149.5MMP9, PTPN11, SOS1
159.4CD68, CSF1
169.4MMP1, MMP9, SOS1
179.4MMP1, MMP9, SOS1
18
Show member pathways
9.4MMP1, PTPN11, SOS1
19
Show member pathways
9.4MMP1, PTPN11, SOS1
20
Show member pathways
9.4MMP1, PTPN11, SOS1
219.2ACP5, CSF1, MMP1
229.2CSF1, CSF1R, PTPN11
239.2CSF1, CSF1R, SOS1
249.2ACP5, CSF1, CSF1R
25
Show member pathways
8.9CSF1, CSF1R, PTPN11, SOS1
268.9CSF1R, MMP1, MMP9, SOS1

GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.1CSF1, CSF1R
2macrophage differentiationGO:003022510.1CSF1, CSF1R
3positive regulation of osteoclast differentiationGO:00456729.9CSF1, CSF1R
4ossificationGO:00015039.7ACP5, CSF1, MMP9
5osteoclast differentiationGO:00303169.7ACP5, CSF1, CSF1R
6dephosphorylationGO:00163119.5ACP5, PTPN11
7innate immune responseGO:00450878.9CSF1, CSF1R, PTPN11, SOS1

Sources for Villonodular Synovitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet