Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 11 13 68
 
Pigmented Villonodular Synovitis 68

Classifications:



External Ids:

Disease Ontology11 DOID:9898
ICD1030 M12.20, M12.2
ICD9CM32 719.2, 719.20

Summaries for Villonodular Synovitis

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Wikipedia:71 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to malignant giant cell tumor and rheumatoid arthritis, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are CXCR4-mediated signaling events and Plasma membrane estrogen receptor signaling. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased cell migration.

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1malignant giant cell tumor29.2ACP5, MMP9, TNFSF11
2rheumatoid arthritis28.4ACP5, MMP9, TNFSF11
3malignant giant cell tumor of the tendon sheath28.3ACP5, MMP9, PTPN11, TNFSF11
4pigmented villonodular synovitis12.7
5noonan syndrome 111.7
6synovitis11.2
7noonan syndrome 411.1
8giant cell tumor10.5
9tenosynovial giant cell tumor10.4
10pterygium colli mental retardation digital anomalies10.3PTPN11, SOS1
11rad51c-related fanconi anemia10.3PTPN11, SOS1
12cervical adenoid basal carcinoma10.3PTPN11, SOS1
13pancreatic serous cystadenocarcinoma10.3PTPN11, SOS1
14growth restriction, severe, with distinctive facies10.3PTPN11, SOS1
15arthritis10.2
16leopard syndrome 110.2PTPN11, SOS1
17noonan syndrome 710.2PTPN11, SOS1
18fibrosing mediastinitis10.2SOS1, VIM
19synovial chondromatosis10.2
20pineal region yolk sac tumor10.2MMP9, VIM
21pauciarticular onset juvenile idiopathic arthritis10.1MMP9, VIM
22fryns macrocephaly10.1ACP5, PTPN11
23neuropathy, ataxia, and retinitis pigmentosa10.1ACP5, PTPN11
24cyclosporiasis10.1ACP5, MMP9
25osteonecrosis10.1
26sarcoma10.1
27tuberculosis10.1
28neuropathy10.1
29pilocytic astrocytoma of cerebellum10.1PTPN11, SOS1
30leukemia, acute myelomonocytic, somatic, somatic10.0PTPN11, SOS1
31hemarthrosis10.0
32diabetes mellitus, insulin-resistant, with acanthosis nigricans10.0PTPN11, SOS1
33adult astrocytic tumour10.0MMP9, VIM
34uv-sensitive syndrome 39.9PTPN11, TNFSF11
35myopia9.9TNFSF11, VIM
36lipoid nephrosis9.9MMP9, TNFSF11
37neurotic disorder9.9PTPN11, TNFSF11
38antidepressant or antipsychotic toxicity or dose selection9.9MMP9, TNFSF11
39bone squamous cell carcinoma9.8MMP9, TNFSF11
40impotence9.8ACP5, TNFSF11
41systemic lupus erythematosus9.8
42chediak-higashi syndrome9.8
43lipoma9.8
44tendinitis9.8
45hemangioma9.8
46osteoarthritis9.8
47lymphoma9.8
48cervicitis9.8
49chondroblastoma9.8
50nodular tenosynovitis9.8

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms & Phenotypes for Villonodular Synovitis

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UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00210-A9.7ACP5, PTPN11, VIM
2GR00055-A-19.7ACP5, SOS1, VIM
3GR00366-A-589.4SOS1, TNFSF11, VIM

MGI Mouse Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.0MMP9, PTPN11, TNFSF11, VIM
2MP:00053978.6MMP9, PTPN11, SOS1, TNFSF11, VIM
3MP:00053878.5MMP9, PTPN11, SOS1, TNFSF11, VIM
4MP:00053698.5MMP9, PTPN11, SOS1, TNFSF11, VIM
5MP:00053917.7MMP9, PTPN11, SOS1, TNFSF11, VIM

Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 1, Phase 26045
2ImmunoglobulinsPhase 1, Phase 26045
3Grapefruit Seed ExtractNutraceuticalPhase 241
4
Paclitaxelapproved, vet_approvedPhase 1275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
5Antineoplastic Agents, PhytogenicPhase 15420
6Albumin-Bound PaclitaxelPhase 12757
7Antimitotic AgentsPhase 15498

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1
8Tenosynovial Giant Cell Tumors (TGCT) Observational Platform ProjectNot yet recruitingNCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

36
Bone, Testes, Lung

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). (28057477)
2017
2
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. (27509331)
2016
3
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. (27190776)
2016
4
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. (26761914)
2016
5
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. (27499236)
2016
6
Multifocal pigmented villonodular synovitis in a child: A case report. (27537585)
2016
7
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. (27169531)
2016
8
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. (26810732)
2016
9
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. (26820289)
2016
10
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. (27130398)
2016
11
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. (27200236)
2016
12
Villonodular synovitis shoulder complicated by rotator cuff rupture. (27068614)
2016
13
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. (28032093)
2016
14
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. (27517031)
2016
15
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. (27843734)
2016
16
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. (27928593)
2016
17
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. (28005642)
2016
18
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. (27866235)
2016
19
Villonodular synovitis of the ankle. Analysis of the risk of recurrence. (27197681)
2016
20
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. (26919624)
2016
21
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. (27462929)
2016
22
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. (27299078)
2015
23
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
24
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
25
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. (26052431)
2015
26
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
27
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. (25637030)
2015
28
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. (26430437)
2015
29
Arthroscopic technique for the treatment of pigmented villonodular synovitis of the hip. (25973372)
2015
30
Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. (25510167)
2015
31
Pigmented Villonodular Synovitis: Potential Pitfall on Oncologic 18F-FDG PET/CT. (26164181)
2015
32
Recurrent pigmented villonodular synovitis and multifocal giant cell tumor of the tendon sheath: case report. (25577961)
2015
33
Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis. (26819567)
2015
34
Surgical treatment of diffuse pigmented villonodular synovitis of the knee. (25936715)
2015
35
Pigmented villonodular synovitis of temporomandibular joint: pathological aspects and surgical treatment. (25937582)
2015
36
A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome. (25967956)
2015
37
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension. (25699525)
2015
38
Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. (25465190)
2015
39
Bilateral pigmented villonodular synovitis of the knee. (26649121)
2015
40
High recurrence and good functional results after arthroscopic resection of pigmented villonodular synovitis. (26231932)
2015
41
The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. (25820897)
2015
42
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. (26067150)
2015
43
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. (26219971)
2015
44
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. (26440548)
2015
45
Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells. (26499059)
2015
46
Surgical outcomes after excision of pigmented villonodular synovitis localized to the ankle and hindfoot without adjuvant therapy. (25618808)
2015
47
Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases. (25799575)
2015
48
Dual-energy computed tomography molecular imaging of pigmented villonodular synovitis. (25504960)
2015
49
Multi-lineage differentiation and angiogenesis potentials of pigmented villonodular synovitis derived mesenchymal stem cells - pathological implication. (26291329)
2015
50
Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst. (27299073)
2015

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.6MMP9, PTPN11
29.5MMP9, SOS1
39.5PTPN11, SOS1
49.5PTPN11, SOS1
59.5PTPN11, SOS1
6
Show member pathways
9.5PTPN11, SOS1
7
Show member pathways
9.5PTPN11, SOS1
8
Show member pathways
9.5PTPN11, SOS1
99.5PTPN11, SOS1
10
Show member pathways
9.5PTPN11, SOS1
119.5PTPN11, SOS1
129.5PTPN11, SOS1
139.5PTPN11, SOS1
14
Show member pathways
9.5PTPN11, SOS1
159.5PTPN11, SOS1
169.1MMP9, PTPN11, SOS1
179.1MMP9, PTPN11, SOS1
189.0ACP5, TNFSF11
199.0ACP5, TNFSF11
209.0MMP9, SOS1, VIM
21
Show member pathways
9.0PTPN11, SOS1, VIM
22
Show member pathways
8.7MMP9, SOS1, TNFSF11
23
Show member pathways
8.7PTPN11, SOS1, TNFSF11
24
Show member pathways
8.7PTPN11, SOS1, TNFSF11

GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1ephrin receptor signaling pathwayGO:004801310.3MMP9, PTPN11
2Bergmann glial cell differentiationGO:006002010.2PTPN11, VIM
3epidermal growth factor receptor signaling pathwayGO:000717310.1PTPN11, SOS1
4multicellular organism growthGO:003526410.1PTPN11, SOS1
5neurotrophin TRK receptor signaling pathwayGO:004801110.1PTPN11, SOS1
6leukocyte migrationGO:00509009.7MMP9, PTPN11, SOS1
7bone resorptionGO:00454539.7ACP5, TNFSF11
8positive regulation of epidermal growth factor receptor signaling pathwayGO:00457429.5MMP9, SOS1
9osteoclast differentiationGO:00303169.4ACP5, TNFSF11
10ossificationGO:00015039.1ACP5, MMP9, TNFSF11

Sources for Villonodular Synovitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet