MCID: VLL003
MIFTS: 50

Villonodular Synovitis malady

Summaries for Villonodular Synovitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Villonodular synovitis is a type of synovial swelling. more...

MalaCards: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is ACP5 (acid phosphatase 5, tartrate resistant), and among its related pathways are Integrins in angiogenesis and Osteopontin Signaling. The compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Villonodular Synovitis

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60UMLS, 8Disease Ontology, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

villonodular synovitis 8
pigmented villonodular synovitis 60


External Ids:

Disease Ontology8 DOID:9898
ICD9CM27 719.20, 719.2
ICD1025 M12.2

Related Diseases for Villonodular Synovitis

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17GeneCards, 18GeneDecks
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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.2MMP1, CD68, TNFRSF11B, TNFSF11
2pigmented villonodular synovitis32.2LAPTM5, ANKLE2, ATP6V1B2, CSF1, CSF1R, PDGFRB
3giant cell tumor31.1BGLAP, CSF1, TNFSF11, TNFRSF11B, MMP9
4arthritis30.7TNFRSF11B, TNFSF11, CSF1, CSF1R, BGLAP, MMP1
5rheumatoid arthritis30.7BGLAP, IBSP, CSF1, TNFSF11, TNFRSF11B, CD68
6osteonecrosis30.4BGLAP
7sarcoma30.2PDGFRB, CSF1R, CSF1
8squamous cell carcinoma30.2IBSP, CSF1R, MMP1, MMP9, PTHLH, SPP1
9melanoma30.1IBSP, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
10osteoarthritis30.1TNFSF11, CSF1, CSF1R, IBSP, BGLAP, TNFRSF11B
11tenosynovial giant cell tumor10.6
12pigmentation disease10.5
13malignant giant cell tumor10.4
14neuropathy10.4
15noonan syndrome10.3
16carpal tunnel syndrome10.3
17hemarthrosis10.3
18tuberculosis10.3
19tendinitis10.1
20chondroblastoma10.1
21nodular tenosynovitis10.1
22malignant giant cell tumor of the tendon sheath10.1
23ulnar neuropathy10.1
24systemic lupus erythematosus10.1
25paget's disease of bone10.1
26reactive arthritis10.1
27peroneal neuropathy10.1
28bone giant cell tumor10.1
29cervicitis10.1
30conjunctivitis10.1
31hemangioma10.1
32lipoma10.1
33lupus erythematosus10.1
34paraplegia10.1
35radial neuropathy10.1
36multicentric reticulohistiocytosis10.0CD68
37histiocytosis10.0CD68
38adenoma10.0PVR
39adult t-cell leukemia10.0PTHLH
40root resorption10.0TNFRSF11B
41endometriosis10.0MMP1
42cystic fibrosis10.0TNFRSF11B
43glomerulonephritis10.0SPP1
44myelofibrosis10.0PDGFRB
45leiomyosarcoma10.0PDGFRB
46arteriosclerosis10.0SPP1
47gastrointestinal stromal tumor10.0PDGFRB
48uterine sarcoma10.0PDGFRB
49multiple myeloma10.0TNFRSF11B, TNFSF11
50osteosclerosis10.0TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Clinical Features for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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32MalaCards
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MalaCards organs/tissues related to Villonodular Synovitis:

32
Bone, Testes, Lung

Animal Models for Villonodular Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Villonodular Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.9CSF1R, CSF1, ACP5
2MP:00107719.2CSF1R, TNFSF11, MMP9, SPP1
3MP:00053829.0PTHLH, TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB
4MP:00053908.2SPP1, IBSP, CALCR, CSF1R, CSF1, TNFSF11
5MP:00053767.7CSF1R, PDGFRB, CALCR, PVR, CSF1, TNFSF11
6MP:00053977.4CALCR, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
7MP:00053877.0PVR, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11

Publications for Villonodular Synovitis

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50PubMed
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Articles related to Villonodular Synovitis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Pigmented villonodular synovitis causing osteonecrosis of the femoral head: a case report. (24416606)
2013
2
Pigmented villonodular synovitis of the shoulder associated with massive rotator cuff tear treated by arthroscopic synovectomy and debridement. (23588830)
2013
3
A low recurrence rate is possible with a combination of surgery and radiosynovectomy for diffuse pigmented villonodular synovitis of the knee. (23751823)
2013
4
Localized Pigmented Villonodular Synovitis of the shoulder: a rare presentation of an uncommon pathology. (24016657)
2013
5
Osteochondral destruction in pigmented villonodular synovitis during the clinical course. (22174203)
2012
6
Pigmented villonodular synovitis of the temporomandibular joint presenting as a middle cranial fossa tumor. (21741744)
2012
7
Clinical results of open synovectomy for treatment of diffuse pigmented villonodular synovitis of the knee: case series and review of literature. (22264713)
2012
8
Malignant pigmented villonodular synovitis in the knee - report of a case with rapid clinical progression. (21270951)
2011
9
Pigmented villonodular synovitis of the ankle: radiologic characteristics. (21622637)
2011
10
Pigmented villonodular synovitis after TKA associated with tibial component loosening. (21815587)
2011
11
Subacromial bony erosion: a rare presentation of pigmented villonodular synovitis of the shoulder. (19252895)
2009
12
Treatment of diffuse pigmented villonodular synovitis of the knee with combined surgical and radiosynovectomy. (19096892)
2009
13
External beam radiation therapy enhances local control in pigmented villonodular synovitis. (19211195)
2009
14
Pigmented villonodular synovitis of the temporomandibular joint. (18780538)
2008
15
Pigmented villonodular synovitis of the temporomandibular joint: a rare tumor of the temporal skull base. (18590445)
2008
16
Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instability. Case report and review of the literature. (17688068)
2007
17
Outcome of 17 pigmented villonodular synovitis (PVNS) of the knee at 6 years mean follow-up. (17600720)
2007
18
Pigmented villonodular synovitis. (16311109)
2006
19
Pigmented villonodular synovitis of the distal radioulnar joint. (16622627)
2006
20
The case: Localized pigmented villonodular synovitis. (16924854)
2006
21
Clinical image: pigmented villonodular synovitis of the knee. (17075827)
2006
22
Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. (16012505)
2005
23
Diffuse pigmented villonodular synovitis: two cases involving the calcaneocuboid joint. (15778475)
2005
24
Pigmented villonodular synovitis of the knee presenting as sciatica. (12943290)
2003
25
Imaging of pigmented villonodular synovitis. (14593562)
2003
26
Localized pigmented villonodular synovitis of the knee. (14627111)
2003
27
True bursal pigmented villonodular synovitis. (12073120)
2002
28
Pigmented villonodular synovitis of the elbow in a 6-year-old girl. (12070502)
2002
29
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
30
Pigment villonodular synovitis of the spine. Case report and review of the literature. (11912473)
2001
31
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
32
Localized pigmented villonodular synovitis presenting as recurrent dislocation of the patella. (11027765)
2000
33
Cell populations involved in pigmented villonodular synovitis of the knee. (10685815)
2000
34
Pigmented villonodular synovitis arising from the subtalar joint: a case report. (9234989)
1997
35
Pigmented villonodular synovitis of the ankle A case report. (24193331)
1995
36
Expression of metalloproteinases in pigmented villonodular synovitis. (8056425)
1994
37
Pigmented villonodular synovitis. Pedal manifestations. (7807386)
1994
38
Localized pigmented villonodular synovitis presenting as a locked lateral meniscal bucket handle tear: a case report and review of the literature. (8086028)
1994
39
Magnetic resonance imaging of pigmented villonodular synovitis in subtalar joint. Report of a case. (1395260)
1992
40
Long-term results of knee synovectomy in pigmented villonodular synovitis. (1736420)
1992
41
Diffuse pigmented villonodular synovitis: non-surgical management. (1888193)
1991
42
Pigmented villonodular synovitis. (2187416)
1990
43
Pigmented villonodular synovitis. (2270966)
1990
44
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
45
Radiologic case study. Diffuse pigmented villonodular synovitis. (2771816)
1989
46
Test and teach. Number Fifty-eight. Pigmented villonodular synovitis of the hip with invasion of pelvic bone. (3241734)
1988
47
The use of MRI to assist in diagnosis of pigmented villonodular synovitis of the knee joint. (3370868)
1988
48
Pigmented villonodular synovitis. (3597511)
1987
49
Localized pigmented villonodular synovitis of the vertebral column. (6546511)
1984
50
Pigmented villonodular synovitis-like lesions in association with rare cases of rheumatoid arthritis, osteonecrosis, and advanced degenerative joint disease. Report of five cases. (6697577)
1984

Genetic Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Villonodular Synovitis

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Pathways for genes affiliated with Villonodular Synovitis

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Villonodular Synovitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24410.6MMP9
2procollagen4410.5TNFSF11, ACP5
3cycloheximide4410.4CSF1R, IBSP
4rantes4410.0CALCR, CSF1, ACP5
5indomethacin44 59 28 1113.0SPP1, CSF1
6estradiol44 11 2412.0IBSP, CALCR, PTHLH, ACP5
7matrigel449.9PTHLH, PDGFRB, MMP1, IBSP
8clodronate44 49 1111.8TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
9prostaglandin449.8TNFRSF11B, CSF1, TNFSF11, MMP1
10geranylgeranyl pyrophosphate449.7TNFSF11, TNFRSF11B, MMP9, MMP1
11etanercept44 49 1111.5TNFSF11, MMP1, CSF1, TNFRSF11B
12celecoxib44 59 28 49 11 2414.4MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
13ibandronate44 1110.4TNFSF11, TNFRSF11B, IBSP, BGLAP
14pyridinoline449.3ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
15deoxypyridinoline449.2TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
16vitamin k2449.2BGLAP, CSF1, TNFRSF11B, TNFSF11
17pamidronate44 49 1111.2MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
18alendronate44 49 1111.1BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
19tgf beta1449.1CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
20infliximab44 49 1111.1SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
21titanium449.0IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
22pd 98,059449.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
2325-hydroxyvitamin d449.0BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
24phosphorus449.0TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
25azathioprine44 49 2 1112.0TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
26tartrate448.9TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
27genistein44 28 59 2 11 2413.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
28troglitazone44 28 59 1111.8MMP1, SPP1, PTHLH, MMP9, CSF1
29hydroxyapatite448.8PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
30ns 39844 599.8MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
31hydroxyproline44 11 2410.7MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
32zoledronic acid448.7BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
33prednisolone44 28 1110.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
34heparin44 28 11 2411.6IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
35ascorbic acid44 249.6MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
36serine448.4MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
37phosphatidylinositol448.4CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
38sb 20358044 599.3SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
39cyclosporin a44 28 5910.3TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
40dexamethasone44 49 28 1111.2TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
41vitamin d448.1CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
421,25 dihydroxy vitamin d3448.0TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
43tyrosine448.0ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
44testosterone44 59 11 2411.0MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
45calcitriol44 59 11 2410.9BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
46retinoic acid44 248.8PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
47creatinine447.7TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
48cysteine447.6MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
49vegf447.6SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
50paraffin447.3PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP

GO Terms for genes affiliated with Villonodular Synovitis

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16Gene Ontology
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Cellular components related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.4SPP1, BGLAP
2extracellular spaceGO:0056157.9SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
3extracellular regionGO:0055767.7BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.1TNFSF11, CSF1
2positive regulation of bone resorptionGO:04578010.0SPP1, TNFSF11
3osteoclast differentiationGO:0303169.9TNFSF11, CSF1, CSF1R
4phosphatidylinositol metabolic processGO:0464889.9CSF1R, PDGFRB
5macrophage differentiationGO:0302259.8MMP9, CSF1, CSF1R
6ossificationGO:0015039.8IBSP, CSF1, TNFSF11
7regulation of bone resorptionGO:0451249.5CSF1R, BGLAP
8extracellular matrix organizationGO:0301989.4IBSP, TNFRSF11B, MMP1, MMP9, SPP1
9response to vitamin DGO:0332809.1SPP1, BGLAP
10skeletal system developmentGO:0015019.1BGLAP, TNFRSF11B, MMP9, PTHLH

Molecular functions related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Villonodular Synovitis

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Sources for Villonodular Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet