Aliases & Classifications for Villonodular Synovitis

Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 12 14 69
Pigmented Villonodular Synovitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD10 33 M12.20 M12.2
ICD9CM 35 719.2 719.20
UMLS 69 C0158168

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to malignant giant cell tumor and pigmented villonodular synovitis, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Rheumatoid arthritis. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Wikipedia : 71 Villonodular synovitis is a type of synovial... more...

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor 29.3 ACP5 CSF1R MMP9 PTPRC TNFSF11
2 pigmented villonodular synovitis 12.8
3 noonan syndrome 1 11.7
4 synovitis 11.2
5 noonan syndrome 4 11.1
6 giant cell tumor 10.5
7 tenosynovial giant cell tumor 10.4
8 arthritis 10.2
9 rheumatoid arthritis 10.2
10 corneal staphyloma 10.2 ACP5 MMP9
11 synovial chondromatosis 10.2
12 spastic hemiplegia 10.1 MMP9 TNFSF11
13 microcephaly 10, primary, autosomal recessive 10.1 ACP5 TNFSF11
14 maroteaux stanescu cousin syndrome 10.1 ACP5 TNFSF11
15 bronchus cancer 10.1 ACP5 TNFSF11
16 central nervous system adult germ cell tumor 10.1 MMP9 VIM
17 statin toxicity 10.1 MMP9 TNFSF11
18 acrorenal syndrome 10.1 ACP5 TNFSF11
19 persistent mullerian duct syndrome 10.1 CSF1R MMP9
20 chromosomal disease 10.1 ACP5 TNFSF11
21 onychocytic matricoma 10.1 MMP9 VIM
22 dysbaric osteonecrosis 10.1 ACP5 TNFSF11
23 sarcoma 10.1
24 neuropathy 10.1
25 tuberculosis 10.1
26 osteonecrosis 10.1
27 classic type lipoma 10.0 ACP5 TNFSF11
28 ischemic bone disease 10.0 ACP5 TNFSF11
29 plague 10.0 MMP9 TNFSF11
30 chiasmal syndrome 10.0 ACP5 PTPRC
31 gerstmann syndrome 10.0 CSF1R VIM
32 hemangioma of liver 10.0 ACP5 PTPRC
33 vascular dementia 10.0 MMP9 TNFSF11
34 bladder papillary transitional cell neoplasm 10.0 ACP5 TNFSF11
35 bulbomembranous urethral cancer 10.0 ACP5 MMP9 TNFSF11
36 hemarthrosis 10.0
37 autistic disorder 10.0 ACP5 MMP9 TNFSF11
38 intrahepatic cholestasis 10.0 MMP9 TNFSF11
39 hinman syndrome 10.0 PTPRC VIM
40 ribbing disease 10.0 PTPRC VIM
41 appendix mucinous cystadenocarcinoma 9.9 PTPRC VIM
42 omodysplasia 2 9.9 PTPRC VIM
43 congenital muscular dystrophy with hyperlaxity 9.9 PTPRC VIM
44 lung benign neoplasm 9.9 PTPRC VIM
45 desmoid tumor 9.9 PTPRC VIM
46 kidney benign neoplasm 9.9 PTPRC VIM
47 diabetes persistent mullerian ducts 9.9 PTPRC VIM
48 glossopharyngeal nerve disease 9.9 CSF1R PTPRC
49 lymphoma 9.8
50 ulnar neuropathy 9.8

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.13 ACP5 CSF1R VIM
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 ACP5 CSF1R PTPRC VIM

MGI Mouse Phenotypes related to Villonodular Synovitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CSF1R MMP9 PTPRC TNFSF11 VIM
2 immune system MP:0005387 9.35 CSF1R MMP9 PTPRC TNFSF11 VIM
3 respiratory system MP:0005388 8.92 MMP9 PTPRC TNFSF11 VIM

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1, Phase 2
2 Antibodies Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 1
6 Antimitotic Agents Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2
3 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Recruiting NCT01643850 Phase 2
4 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2
6 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Recruiting NCT02673736 Phase 1
7 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1
8 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

39
Bone, Lung, Testes

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 590)
id Title Authors Year
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
2
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
3
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. ( 26919624 )
2016
4
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
5
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. ( 28032093 )
2016
6
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
7
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
8
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016
9
Villonodular synovitis shoulder complicated by rotator cuff rupture. ( 27068614 )
2016
10
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
11
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
12
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
13
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. ( 27190776 )
2016
14
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. ( 26810732 )
2016
15
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
16
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
17
Multifocal pigmented villonodular synovitis in a child: A case report. ( 27537585 )
2016
18
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. ( 27462929 )
2016
19
Villonodular synovitis of the ankle. Analysis of the risk of recurrence. ( 27197681 )
2016
20
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
21
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. ( 27200236 )
2016
22
Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. ( 25510167 )
2015
23
Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. ( 25465190 )
2015
24
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. ( 27299078 )
2015
25
A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome. ( 25967956 )
2015
26
Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst. ( 27299073 )
2015
27
Use of yttrium-90 hydroxyapatite radiosynovectomy as a primary modality of treatment in diffuse pigmented villonodular synovitis of the knee joint: A first case report. ( 25589806 )
2015
28
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. ( 26430437 )
2015
29
Pigmented Villonodular Synovitis: Potential Pitfall on Oncologic 18F-FDG PET/CT. ( 26164181 )
2015
30
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. ( 25836023 )
2015
31
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. ( 26067150 )
2015
32
Arthroscopic T-capsulotomy for Excision of Pigmented Villonodular Synovitis in the Hip. ( 25901612 )
2015
33
Recurrent pigmented villonodular synovitis and multifocal giant cell tumor of the tendon sheath: case report. ( 25577961 )
2015
34
Surgical outcomes after excision of pigmented villonodular synovitis localized to the ankle and hindfoot without adjuvant therapy. ( 25618808 )
2015
35
Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis. ( 26819567 )
2015
36
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. ( 26553457 )
2015
37
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. ( 25637030 )
2015
38
Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. ( 25854167 )
2015
39
Surgical treatment of diffuse pigmented villonodular synovitis of the knee. ( 25936715 )
2015
40
Primary synovial epithelioid sarcoma of the knee: distinctly unusual location leading to its confusion with pigmented villonodular synovitis. ( 25801084 )
2015
41
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. ( 26440548 )
2015
42
Pigmented villonodular synovitis of temporomandibular joint: pathological aspects and surgical treatment. ( 25937582 )
2015
43
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. ( 25459320 )
2015
44
The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. ( 25820897 )
2015
45
Dual-energy computed tomography molecular imaging of pigmented villonodular synovitis. ( 25504960 )
2015
46
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. ( 26219971 )
2015
47
Bilateral pigmented villonodular synovitis of the knee. ( 26649121 )
2015
48
Pigmented villonodular synovitis of the temporomandibular joint: Case report and review of literature. ( 25821131 )
2015
49
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. ( 26052431 )
2015
50
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension. ( 25699525 )
2015

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.26 MMP9 TNFSF11
2 osteoclast differentiation GO:0030316 9.16 CSF1R TNFSF11
3 bone resorption GO:0045453 8.96 ACP5 TNFSF11
4 macrophage differentiation GO:0030225 8.62 CSF1R MMP9

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....