MCID: VLL003
MIFTS: 34

Villonodular Synovitis malady

Bone diseases category

Aliases & Classifications for Villonodular Synovitis

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Aliases & Descriptions for Villonodular Synovitis:

Name: Villonodular Synovitis 10 12 65
 
Pigmented Villonodular Synovitis 65


Classifications:



External Ids:

Disease Ontology10 DOID:9898
ICD9CM29 719.2, 719.20
ICD1027 M12.2

Summaries for Villonodular Synovitis

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Wikipedia:68 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways are Plasma membrane estrogen receptor signaling and Syndecan-1-mediated signaling events. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are muscle and vision/eye.

Related Diseases for Villonodular Synovitis

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Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Grapefruit Seed ExtractNutraceuticalPhase 236

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)RecruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1
7A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorNot yet recruitingNCT02673736Phase 1

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

33
Bone, Testes, Lung

Animal Models for Villonodular Synovitis or affiliated genes

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MGI Mouse Phenotypes related to Villonodular Synovitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8MMP9, PTPN11, SOS1, VIM
2MP:00053918.8MMP9, PTPN11, SOS1, VIM
3MP:00053718.4ACP5, MMP9, PTPN11, TNFSF11
4MP:00053908.0ACP5, MMP9, PTPN11, SOS1, TNFSF11
5MP:00053877.0ACP5, MMP9, PTPN11, SOS1, TNFSF11, VIM
6MP:00053976.8ACP5, MMP9, PTPN11, SOS1, TNFSF11, VIM

Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. (26219971)
2015
2
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
3
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
4
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. (26440548)
2015
5
Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells. (26499059)
2015
6
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
7
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
8
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
9
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
10
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
11
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
12
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
13
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
14
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
15
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
16
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
17
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
18
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
19
Pigmented villonodular synovitis. (16311109)
2006
20
Clustered localized pigmented villonodular synovitis. (15944639)
2005
21
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
22
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
23
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
24
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
25
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
26
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
27
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
28
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
29
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
30
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
31
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
32
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
33
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
34
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
35
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
36
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
37
Radiographic diagnosis--canine carpal villonodular synovitis. (9491512)
1998
38
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
39
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
40
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
41
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
42
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
43
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
44
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
45
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
46
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
47
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
48
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
49
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MMP9, SOS1
29.6MMP9, SOS1
39.5MMP9, PTPN11
49.5PTPN11, SOS1
5
Show member pathways
9.5PTPN11, SOS1
69.5PTPN11, SOS1
79.5PTPN11, SOS1
89.5PTPN11, SOS1
99.5PTPN11, SOS1
109.5PTPN11, SOS1
119.5PTPN11, SOS1
129.5PTPN11, SOS1
13
Show member pathways
9.5PTPN11, SOS1
14
Show member pathways
9.5PTPN11, SOS1
159.5PTPN11, SOS1
16
Show member pathways
9.5PTPN11, SOS1
179.1MMP9, PTPN11, SOS1
189.1MMP9, PTPN11, SOS1
199.1MMP9, PTPN11, SOS1
209.1MMP9, SOS1, VIM
219.0ACP5, TNFSF11
229.0ACP5, TNFSF11
23
B cell receptor signaling pathway (KEGG)
Show member pathways
9.0ACP5, TNFSF11
24
Show member pathways
8.7PTPN11, SOS1, TNFSF11
25
Show member pathways
8.7PTPN11, SOS1, TNFSF11

GO Terms for genes affiliated with Villonodular Synovitis

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Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epidermal growth factor receptor signaling pathwayGO:004574210.2MMP9, SOS1
2ephrin receptor signaling pathwayGO:00480139.9MMP9, PTPN11
3leukocyte migrationGO:00509009.3MMP9, PTPN11, SOS1
4bone resorptionGO:00454539.3ACP5, TNFSF11
5ossificationGO:00015039.3MMP9, TNFSF11
6axon guidanceGO:00074119.1MMP9, PTPN11, SOS1

Sources for Villonodular Synovitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet