MCID: VLL003
MIFTS: 45

Villonodular Synovitis malady

Summaries for Villonodular Synovitis

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Wikipedia:63 Villonodular synovitis is a type of synovial swelling. more...

MalaCards based summary: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Syndecan-1-mediated signaling events and Osteopontin Signaling. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Aliases & Classifications for Villonodular Synovitis

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Villonodular Synovitis, Aliases & Descriptions:

Name: Villonodular Synovitis 9 60
 
Pigmented Villonodular Synovitis 60


Classifications:



External Ids:

Disease Ontology9 DOID:9898
ICD9CM27 719.20, 719.2
ICD1025 M12.2

Related Diseases for Villonodular Synovitis

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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.6CD68, MMP1, TNFRSF11B, TNFSF11
2pigmented villonodular synovitis31.8PDGFRB, CSF1, CSF1R, MOAP1, ANKLE2, LAPTM5
3giant cell tumor31.5TNFSF11, CSF1R, CSF1
4osteonecrosis31.3BGLAP
5arthritis29.8BGLAP, TNFSF11, TNFRSF11B, MMP9, MMP1, ACP5
6rheumatoid arthritis29.4TNFSF11, IBSP, BGLAP, SPP1, TNFRSF11B, MMP9
7osteoarthritis28.4MMP1, MMP9, PTHLH, TNFRSF11B, TNFSF11, IBSP
8melanoma28.2SPP1, IBSP, TNFSF11, TNFRSF11B, MMP9, MMP1
9tenosynovial giant cell tumor10.7
10multicentric reticulohistiocytosis10.6CD68
11histiocytosis10.6CD68
12camurati-engelmann disease10.5BGLAP
13synovial chondromatosis10.5
14malignant giant cell tumor10.4
15neuropathy10.4
16tuberculosis10.4
17cherubism10.4TNFSF11
18periapical granuloma10.4TNFSF11
19pseudohypoparathyroidism, type ib10.4PTHLH, BGLAP
20osteopetrosis, autosomal dominant 210.4BGLAP, TNFSF11
21fibrous dysplasia10.4IBSP, BGLAP
22paget disease, juvenile10.4TNFSF11, TNFRSF11B
23osteolysis, familial expansile10.4TNFSF11, TNFRSF11B
24pseudohypoparathyroidism10.4PTHLH, BGLAP
25hemarthrosis10.4
26sarcoma10.4
27osteomyelitis10.3IBSP, TNFSF11, ACP5
28hyperostosis, endosteal10.3TNFRSF11B, TNFSF11
29dentin dysplasia10.3SPP1, IBSP
30nephrolithiasis10.3IBSP, SPP1
31dentinogenesis imperfecta10.3SPP1, IBSP
32langerhans-cell histiocytosis10.3CSF1, CD68
33renal osteodystrophy10.3BGLAP, TNFRSF11B, ACP5
34fibromatosis10.3PDGFRB
35osteomalacia10.3PTHLH, TNFRSF11B, BGLAP
36malignant histiocytosis10.3CSF1, CSF1R
37hypophosphatemia10.3PTHLH, BGLAP
38acute myelomonocytic leukemia10.3CSF1R, CSF1
39primary hyperparathyroidism10.2BGLAP, IBSP, PTHLH, ACP5
40hypoparathyroidism10.2PTHLH, BGLAP
41spondyloarthropathy 110.2TNFRSF11B, TNFSF11, BGLAP
42thalassemia, hispanic gamma-delta-beta10.2TNFSF11, TNFRSF11B
43rheumatic disease10.2BGLAP, TNFSF11, TNFRSF11B
44gaucher's disease10.2ACP5, BGLAP
45systemic lupus erythematosus10.2
46lipoma10.2
47tendinitis10.2
48hemangioma10.2
49nodular tenosynovitis10.2
50malignant giant cell tumor of the tendon sheath10.2

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Symptoms for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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Drug clinical trials:

Search ClinicalTrials for Villonodular Synovitis

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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MalaCards organs/tissues related to Villonodular Synovitis:

31
Bone, Lung, Testes

Animal Models for Villonodular Synovitis or affiliated genes

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Publications for Villonodular Synovitis

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Articles related to Villonodular Synovitis:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
2
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
3
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
4
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
5
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
6
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
7
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
8
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
9
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
10
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
11
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
12
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
13
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
14
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
15
Pigmented villonodular synovitis. (16311109)
2006
16
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
17
Clustered localized pigmented villonodular synovitis. (15944639)
2005
18
Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. (16012505)
2005
19
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
20
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
21
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
22
Pigmented villonodular synovitis of the knee presenting as sciatica. (12943290)
2003
23
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
24
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
25
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
26
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
27
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
28
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
29
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
30
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
31
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
32
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
33
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
34
Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings. (9888766)
1999
35
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
36
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
37
Radiographic diagnosis--canine carpal villonodular synovitis. (9491512)
1998
38
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
39
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
40
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
41
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
42
Evaluation of the hip with pigmented villonodular synovitis. A case report. (1735210)
1992
43
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
44
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
45
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
46
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
47
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
48
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
49
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

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Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP9, MMP1
29.8SPP1, MMP9
3
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.8ACP5, TNFRSF11B, TNFSF11
49.7CD68, CSF1
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.6MMP9, TNFRSF11B, TNFSF11
69.6MMP1, MMP9, BGLAP
79.6CSF1, CSF1R, SPP1
89.6MMP9, PTHLH, SPP1
99.6SPP1, BGLAP, MMP9
109.5PDGFRB, CSF1, CSF1R
119.5CSF1R, CSF1, PDGFRB
129.5SPP1, TNFSF11, TNFRSF11B, ACP5
139.4TNFRSF11B, TNFSF11, BGLAP, SPP1
149.4IBSP, TNFSF11, TNFRSF11B, PDGFRB
15
Show member pathways
9.3SPP1, IBSP, MMP9, MMP1
169.3LAPTM5, ACP5, CD68
179.3PTHLH, TNFSF11, IBSP, BGLAP, SPP1
189.2PDGFRB, CSF1R, MMP1, MMP9
199.2TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
20
Show member pathways
9.0TNFSF11, TNFRSF11B, CSF1R, CSF1, PDGFRB
219.0SPP1, IBSP, CSF1R, CSF1, PDGFRB
22
Show member pathways
9.0PDGFRB, CSF1, CSF1R, TNFSF11, SPP1
238.6CSF1, ACP5, MMP1, TNFSF11, ATP6V1B2

Compounds for genes affiliated with Villonodular Synovitis

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Compounds related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1pyridinoline4310.6TNFRSF11B
2ibandronate43 1210.8TNFRSF11B, IBSP, BGLAP, TNFSF11
3deoxypyridinoline439.7TNFSF11, IBSP, ACP5, BGLAP, TNFRSF11B
4tartrate439.6CSF1, PTHLH, TNFSF11, BGLAP, ACP5
5pamidronate43 49 1211.6BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
6alendronate43 49 1211.5PTHLH, TNFRSF11B, TNFSF11, MMP1, BGLAP
7vitamin k2439.5BGLAP, TNFSF11, TNFRSF11B, CSF1
8clodronate43 49 1211.5MMP1, TNFSF11, TNFRSF11B, PTHLH, BGLAP, ACP5
9titanium439.4SPP1, IBSP, ACP5, TNFRSF11B, TNFSF11, BGLAP
1025-hydroxyvitamin d439.4PTHLH, TNFSF11, TNFRSF11B, ACP5, BGLAP, SPP1
11phosphorus439.4BGLAP, PTHLH, SPP1, TNFSF11, ACP5, TNFRSF11B
12infliximab43 49 1211.4MMP1, TNFRSF11B, BGLAP, SPP1, TNFSF11
13hydroxyapatite439.2IBSP, TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH
14hydroxyproline43 24 1211.1ACP5, MMP9, PTHLH, TNFRSF11B, IBSP, MMP1
15zoledronic acid439.1BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9
16azathioprine43 2 49 1212.1PCNA, PTHLH, TNFRSF11B, BGLAP, TNFSF11, ACP5
17geranylgeranyl pyrophosphate439.0TNFRSF11B, MMP9, MMP1, TNFSF11
18celecoxib43 59 28 49 24 1213.8TNFSF11, TNFRSF11B, MMP9, MMP1, PCNA, CSF1
19prostaglandin438.8PTHLH, MMP9, MMP1, CSF1, TNFRSF11B, TNFSF11
20tgf beta1438.8PTHLH, SPP1, TNFRSF11B, MMP1, CSF1, PDGFRB
21matrigel438.7IBSP, SPP1, PTHLH, MMP9, PDGFRB, MMP1
22rantes438.7MMP1, MMP9, TNFRSF11B, TNFSF11, CSF1, ACP5
23ns 39843 599.7BGLAP, TNFSF11, TNFRSF11B, MMP9, PCNA, MMP1
241,25 dihydroxy vitamin d3438.7CSF1, CSF1R, ACP5, PTHLH, TNFRSF11B, TNFSF11
25estradiol43 24 1210.7IBSP, ACP5, MMP1, TNFRSF11B, TNFSF11, PTHLH
26pd 98,059438.7CSF1, CSF1R, MMP9, TNFSF11, IBSP, MMP1
27vitamin d438.6BGLAP, SPP1, CSF1R, TNFSF11, IBSP, PTHLH
28indomethacin43 28 59 1211.6SPP1, TNFSF11, PTHLH, CSF1, TNFRSF11B, PCNA
29nicotine43 28 49 1211.5MMP1, PTHLH, CSF1, SPP1, PCNA, MMP9
30calcitriol43 59 24 1211.5TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
31ascorbic acid43 249.5SPP1, CSF1, BGLAP, IBSP, TNFRSF11B, MMP1
32cyclosporin a43 28 5910.4TNFRSF11B, BGLAP, SPP1, TNFSF11, MMP9, MMP1
33cycloheximide438.4SPP1, MMP9, TNFRSF11B, TNFSF11, MMP1, IBSP
34heparin43 28 24 1211.3PTHLH, BGLAP, TNFSF11, IBSP, SPP1, TNFRSF11B
35procollagen438.3SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PCNA
36phosphatidylinositol438.2IBSP, SPP1, TNFRSF11B, PTHLH, TNFSF11, CSF1R
37progesterone43 28 59 24 1212.2SPP1, TNFRSF11B, PTHLH, MMP1, CSF1R, CSF1
38genistein43 28 59 2 24 1213.2PCNA, MMP9, SPP1, PDGFRB, TNFSF11, MMP1
39h2o2438.2TNFSF11, PDGFRB, MMP1, BGLAP, SPP1, CSF1
40pge2438.0TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1, ACP5
41testosterone43 59 24 1210.8CSF1, TNFRSF11B, TNFSF11, PTHLH, MMP9, BGLAP
42creatinine437.8CSF1, PCNA, ACP5, MMP1, MMP9, PTHLH
43tyrosine437.7CSF1, CSF1R, ACP5, MMP9, PTHLH, TNFRSF11B
44serine437.7TNFRSF11B, IBSP, BGLAP, SPP1, PTHLH, MMP9
45retinoic acid43 248.7CSF1R, PDGFRB, CSF1, PCNA, TNFRSF11B, MMP1
46dexamethasone43 49 28 1210.5CSF1, CSF1R, PCNA, ACP5, MMP1, MMP9
47vegf437.3IBSP, BGLAP, SPP1, TNFSF11, TNFRSF11B, PTHLH
48cysteine437.3CSF1R, TNFSF11, PDGFRB, TNFRSF11B, IBSP, BGLAP
49estrogen437.1IBSP, PDGFRB, CSF1, PTHLH, SPP1, BGLAP
50paraffin436.9ACP5, MMP1, MMP9, TNFSF11, IBSP, BGLAP

GO Terms for genes affiliated with Villonodular Synovitis

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Cellular components related to Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:00319889.9BGLAP, SPP1
2extracellular regionGO:00055768.3MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
3extracellular spaceGO:00056158.2SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of bone resorptionGO:004512410.2CSF1R, BGLAP
2osteoclast proliferationGO:000215810.2TNFSF11, CSF1
3positive regulation of bone resorptionGO:004578010.1TNFSF11, SPP1
4response to vitamin DGO:003328010.1BGLAP, SPP1
5phosphatidylinositol metabolic processGO:004648810.1PDGFRB, CSF1R
6biomineral tissue developmentGO:003121410.0IBSP, SPP1
7osteoclast differentiationGO:00303169.9CSF1, CSF1R, TNFSF11
8osteoblast developmentGO:00020769.9BGLAP, PTHLH
9positive regulation of osteoclast differentiationGO:00456729.9TNFSF11, CSF1
10macrophage differentiationGO:00302259.8MMP9, CSF1R, CSF1
11extracellular matrix disassemblyGO:00226179.7SPP1, MMP9, MMP1
12bone resorptionGO:00454539.7ACP5, TNFSF11
13skeletal system developmentGO:00015019.7MMP9, PTHLH, TNFRSF11B, BGLAP
14positive regulation of cell migrationGO:00303359.7CSF1R, CSF1, PDGFRB
15ossificationGO:00015039.6CSF1, MMP9, TNFSF11, IBSP
16phosphatidylinositol-mediated signalingGO:00480159.5PDGFRB, CSF1R, PCNA
17positive regulation of cell proliferationGO:00082849.4PTHLH, CSF1R, CSF1, PDGFRB
18extracellular matrix organizationGO:00301989.4SPP1, IBSP, TNFRSF11B, MMP9, MMP1

Molecular functions related to Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Villonodular Synovitis

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Sources for Villonodular Synovitis

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3CDC
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