MCID: VLL003
MIFTS: 50

Villonodular Synovitis malady

Summaries for Villonodular Synovitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Villonodular synovitis is a type of synovial swelling. more...

MalaCards: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is ACP5 (acid phosphatase 5, tartrate resistant), and among its related pathways are Integrins in angiogenesis and Osteopontin Signaling. The compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Villonodular Synovitis

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60UMLS, 8Disease Ontology, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

villonodular synovitis 8
pigmented villonodular synovitis 60


External Ids:

Disease Ontology8 DOID:9898
ICD9CM27 719.20, 719.2
ICD1025 M12.2

Related Diseases for Villonodular Synovitis

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17GeneCards, 18GeneDecks
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Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.2MMP1, CD68, TNFRSF11B, TNFSF11
2pigmented villonodular synovitis32.2LAPTM5, ANKLE2, ATP6V1B2, CSF1, CSF1R, PDGFRB
3giant cell tumor31.1BGLAP, CSF1, TNFSF11, TNFRSF11B, MMP9
4arthritis30.7TNFRSF11B, TNFSF11, CSF1, CSF1R, BGLAP, MMP1
5rheumatoid arthritis30.7BGLAP, IBSP, CSF1, TNFSF11, TNFRSF11B, CD68
6osteonecrosis30.4BGLAP
7sarcoma30.2PDGFRB, CSF1R, CSF1
8squamous cell carcinoma30.2IBSP, CSF1R, MMP1, MMP9, PTHLH, SPP1
9melanoma30.1IBSP, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
10osteoarthritis30.1TNFSF11, CSF1, CSF1R, IBSP, BGLAP, TNFRSF11B
11tenosynovial giant cell tumor10.6
12pigmentation disease10.5
13malignant giant cell tumor10.4
14neuropathy10.4
15noonan syndrome10.3
16carpal tunnel syndrome10.3
17hemarthrosis10.3
18tuberculosis10.3
19tendinitis10.1
20chondroblastoma10.1
21nodular tenosynovitis10.1
22malignant giant cell tumor of the tendon sheath10.1
23ulnar neuropathy10.1
24systemic lupus erythematosus10.1
25paget's disease of bone10.1
26reactive arthritis10.1
27peroneal neuropathy10.1
28bone giant cell tumor10.1
29cervicitis10.1
30conjunctivitis10.1
31hemangioma10.1
32lipoma10.1
33lupus erythematosus10.1
34paraplegia10.1
35radial neuropathy10.1
36multicentric reticulohistiocytosis10.0CD68
37histiocytosis10.0CD68
38adenoma10.0PVR
39adult t-cell leukemia10.0PTHLH
40root resorption10.0TNFRSF11B
41endometriosis10.0MMP1
42cystic fibrosis10.0TNFRSF11B
43glomerulonephritis10.0SPP1
44myelofibrosis10.0PDGFRB
45leiomyosarcoma10.0PDGFRB
46arteriosclerosis10.0SPP1
47gastrointestinal stromal tumor10.0PDGFRB
48uterine sarcoma10.0PDGFRB
49multiple myeloma10.0TNFRSF11B, TNFSF11
50osteosclerosis10.0TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Clinical Features for Villonodular Synovitis

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Drugs & Therapeutics for Villonodular Synovitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

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Anatomical Context for Villonodular Synovitis

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32MalaCards
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MalaCards organs/tissues related to Villonodular Synovitis:

32
Bone, Lung, Testes

Animal Models for Villonodular Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Villonodular Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.9CSF1R, CSF1, ACP5
2MP:00107719.2CSF1R, TNFSF11, MMP9, SPP1
3MP:00053829.0PTHLH, TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB
4MP:00053908.2SPP1, IBSP, CALCR, CSF1R, CSF1, TNFSF11
5MP:00053767.7CSF1R, PDGFRB, CALCR, PVR, CSF1, TNFSF11
6MP:00053977.4CALCR, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
7MP:00053877.0PVR, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11

Publications for Villonodular Synovitis

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50PubMed
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Articles related to Villonodular Synovitis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Pigmented villonodular synovitis of the temporomandibular joint. (23904309)
2013
2
Pigmented villonodular synovitis: dedicated PET imaging findings. (23598941)
2013
3
Pigmented villonodular synovitis: a retrospective study of seventy five cases (eighty one joints). (23503697)
2013
4
Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. (23450025)
2013
5
Pigmented villonodular synovitis of the left distal biceps tendon. (23682455)
2013
6
Bilateral diffuse pigmented villonodular synovitis of the knee. (23288770)
2013
7
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
8
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
9
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
10
Osteoclast formation and function in pigmented villonodular synovitis. (21706481)
2011
11
Pigmented villonodular synovitis of the temporomandibular joint: a case report and the literature review. (21474285)
2011
12
Pediatric pigmented villonodular synovitis mimicking a septic hip. (20216127)
2010
13
Pigmented villonodular synovitis of a lumbar intervertebral facet joint. (19303820)
2009
14
Pigmented villonodular synovitis of the knee in a patient on oral anticoagulation therapy: a case report. (20062764)
2009
15
Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). (18296418)
2008
16
Pigmented villonodular synovitis: radiologic-pathologic correlation. (18794322)
2008
17
Pigmented villonodular synovitis managed by Yttrium 90 after debulking surgery. (18690320)
2008
18
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
19
Pigmented villonodular synovitis of the pes anserine bursa. (17665791)
2007
20
Diffuse pigmented villonodular synovitis: preliminary results with intralesional resection and p32 synoviorthesis. (16906091)
2007
21
Pigmented villonodular synovitis originating from the lumbar facet joint: a case report. (17566795)
2007
22
An unusual case of pigmented villonodular synovitis after total knee arthroplasty. (18078898)
2007
23
What affects the recurrence and clinical outcome of pigmented villonodular synovitis? (16760805)
2006
24
Pigmented villonodular synovitis about the ankle: a review of the literature and presentation in 10 athletic patients. (15574243)
2004
25
Pigmented villonodular synovitis of the foot and ankle: a 12-year experience from a tertiary orthopedic Oncology Unit. (15605054)
2004
26
Cytologic appearance of pigmented villonodular synovitis. A case report. (12146040)
2002
27
Two contrasting presentations of localised pigmented villonodular synovitis of the knee. (12444513)
2002
28
Combined partial arthroscopic synovectomy and radiation therapy for diffuse pigmented villonodular synovitis of the knee. (11337722)
2001
29
Pigmented villonodular synovitis. Review of 20 cases. (11469471)
2001
30
Pigmented villonodular synovitis following arthroscopic laser surgery of the knee. (11288016)
2001
31
Extra-articular pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. (11202319)
2000
32
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
33
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
34
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
35
Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. (9094994)
1997
36
Localized pigmented villonodular synovitis: a rare cause of locking of the knee. (9276062)
1997
37
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (9042281)
1997
38
Neuropathy secondary to pigmented villonodular synovitis of the hip. (8998871)
1996
39
Outcome following radiation treatment for high-risk pigmented villonodular synovitis. (7790264)
1995
40
Recurrent spontaneous hemarthrosis nine years after a total knee arthroplasty. A presentation with pigmented villonodular synovitis. (8501094)
1993
41
Recurrence of pigmented villonodular synovitis of the knee 17 years after the initial treatment. A case report. (8403645)
1993
42
Gadolinium-enhanced MRI of pigmented villonodular synovitis of the knee. (1430457)
1992
43
Treatment of pigmented villonodular synovitis with yttrium-90: changes in immunologic features, Tc-99m uptake measurements, and MR imaging of one case. (1319881)
1992
44
X-chromosome inactivation in patients who have pigmented villonodular synovitis. (1748702)
1991
45
Concentric joint space narrowing of the hip associated with hemosiderotic synovitis (HS) including pigmented villonodular synovitis (PVNS). (3358135)
1988
46
Magnetic resonance imaging of pigmented villonodular synovitis: a report of two cases. (3616670)
1987
47
Diagnostic arthroscopy of the hip joint in pigmented villonodular synovitis. (3689528)
1987
48
Characteristics of foam cells in pigmented villonodular synovitis. Immunomorphological and enzymological studies. (6474278)
1984
49
Simultaneous villonodular synovitis and synovial chondromatosis of the temporomandibular joint: report of case. (6943321)
1981
50
Villonodular synovitis with synovial chondromatosis. (268579)
1977

Genetic Variations for Villonodular Synovitis

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Expression for genes affiliated with Villonodular Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Villonodular Synovitis

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Pathways for genes affiliated with Villonodular Synovitis

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Villonodular Synovitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24410.6MMP9
2procollagen4410.5TNFSF11, ACP5
3cycloheximide4410.4CSF1R, IBSP
4rantes4410.0ACP5, CSF1, CALCR
5indomethacin44 59 28 1113.0SPP1, CSF1
6estradiol44 11 2412.0PTHLH, ACP5, CALCR, IBSP
7matrigel449.9IBSP, PDGFRB, MMP1, PTHLH
8clodronate44 49 1111.8TNFSF11, TNFRSF11B, MMP1, ACP5, PTHLH
9prostaglandin449.8CSF1, TNFSF11, TNFRSF11B, MMP1
10geranylgeranyl pyrophosphate449.7TNFSF11, TNFRSF11B, MMP1, MMP9
11etanercept44 49 1111.5MMP1, TNFRSF11B, TNFSF11, CSF1
12celecoxib44 59 28 49 11 2414.4MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
13ibandronate44 1110.4BGLAP, IBSP, TNFSF11, TNFRSF11B
14pyridinoline449.3BGLAP, IBSP, TNFRSF11B, ACP5, PTHLH
15deoxypyridinoline449.2BGLAP, IBSP, TNFSF11, TNFRSF11B, ACP5
16vitamin k2449.2TNFRSF11B, TNFSF11, CSF1, BGLAP
17pamidronate44 49 1111.2BGLAP, TNFSF11, TNFRSF11B, MMP1, PTHLH
18alendronate44 49 1111.1BGLAP, TNFSF11, TNFRSF11B, MMP1, PTHLH
19tgf beta1449.1PDGFRB, CSF1, TNFRSF11B, MMP1, MMP9, PTHLH
20infliximab44 49 1111.1BGLAP, TNFSF11, TNFRSF11B, MMP1, SPP1
21titanium449.0BGLAP, IBSP, TNFSF11, TNFRSF11B, ACP5, SPP1
22pd 98,059449.0MMP9, MMP1, TNFSF11, CSF1, CSF1R, IBSP
2325-hydroxyvitamin d449.0BGLAP, TNFSF11, TNFRSF11B, ACP5, PTHLH, SPP1
24phosphorus449.0BGLAP, TNFSF11, TNFRSF11B, ACP5, PTHLH, SPP1
25azathioprine44 49 2 1112.0BGLAP, TNFSF11, TNFRSF11B, ACP5, PTHLH
26tartrate448.9BGLAP, CALCR, CSF1, TNFSF11, ACP5, PTHLH
27genistein44 28 59 2 11 2413.9PDGFRB, CSF1, TNFSF11, TNFRSF11B, MMP1, MMP9
28troglitazone44 28 59 1111.8CSF1, MMP1, MMP9, PTHLH, SPP1
29hydroxyapatite448.8BGLAP, IBSP, TNFSF11, TNFRSF11B, ACP5, PTHLH
30ns 39844 599.8BGLAP, CSF1, TNFSF11, TNFRSF11B, MMP1, MMP9
31hydroxyproline44 11 2410.7BGLAP, IBSP, TNFRSF11B, MMP1, MMP9, ACP5
32zoledronic acid448.7BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9
33prednisolone44 28 1110.7BGLAP, CSF1, TNFRSF11B, MMP1, PTHLH
34heparin44 28 11 2411.6BGLAP, IBSP, CSF1, TNFSF11, TNFRSF11B, ACP5
35ascorbic acid44 249.6BGLAP, IBSP, CSF1, TNFSF11, TNFRSF11B, MMP1
36serine448.4BGLAP, CSF1R, CSF1, TNFSF11, TNFRSF11B, MMP1
37phosphatidylinositol448.4IBSP, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11
38sb 20358044 599.3BGLAP, TNFSF11, TNFRSF11B, MMP1, MMP9, SPP1
39cyclosporin a44 28 5910.3BGLAP, CALCR, TNFSF11, TNFRSF11B, MMP1, MMP9
40dexamethasone44 49 28 1111.2BGLAP, IBSP, CALCR, CSF1R, TNFSF11, TNFRSF11B
41vitamin d448.1BGLAP, IBSP, CALCR, PDGFRB, CSF1R, TNFSF11
421,25 dihydroxy vitamin d3448.0SPP1, PTHLH, ACP5, TNFRSF11B, TNFSF11, CSF1
43tyrosine448.0IBSP, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11
44testosterone44 59 11 2411.0BGLAP, PDGFRB, CSF1, TNFSF11, TNFRSF11B, MMP1
45calcitriol44 59 11 2410.9CSF1, PDGFRB, CALCR, BGLAP, TNFSF11, TNFRSF11B
46retinoic acid44 248.8BGLAP, PDGFRB, CSF1R, CSF1, TNFRSF11B, MMP1
47creatinine447.7CSF1, CALCR, IBSP, BGLAP, TNFSF11, TNFRSF11B
48cysteine447.6BGLAP, IBSP, PDGFRB, CSF1R, CSF1, TNFSF11
49vegf447.6BGLAP, IBSP, PDGFRB, CSF1R, CSF1, TNFSF11
50paraffin447.3SPP1, PTHLH, ACP5, MMP9, MMP1, CD68

GO Terms for genes affiliated with Villonodular Synovitis

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16Gene Ontology
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Cellular components related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.4SPP1, BGLAP
2extracellular spaceGO:0056157.9SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
3extracellular regionGO:0055767.7BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.1TNFSF11, CSF1
2positive regulation of bone resorptionGO:04578010.0SPP1, TNFSF11
3osteoclast differentiationGO:0303169.9TNFSF11, CSF1, CSF1R
4phosphatidylinositol metabolic processGO:0464889.9CSF1R, PDGFRB
5macrophage differentiationGO:0302259.8MMP9, CSF1, CSF1R
6ossificationGO:0015039.8IBSP, CSF1, TNFSF11
7regulation of bone resorptionGO:0451249.5CSF1R, BGLAP
8extracellular matrix organizationGO:0301989.4IBSP, TNFRSF11B, MMP1, MMP9, SPP1
9response to vitamin DGO:0332809.1SPP1, BGLAP
10skeletal system developmentGO:0015019.1BGLAP, TNFRSF11B, MMP9, PTHLH

Molecular functions related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Villonodular Synovitis

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Sources for Villonodular Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet