MCID: VLL003
MIFTS: 47

Villonodular Synovitis malady

Summaries for Villonodular Synovitis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Villonodular synovitis is a type of synovial swelling. more...

MalaCards: Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis. An important gene associated with Villonodular Synovitis is ACP5 (acid phosphatase 5, tartrate resistant), and among its related pathways are Integrins in angiogenesis and Osteopontin Signaling. The compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include lung and skeletal muscle, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Villonodular Synovitis

Sources:
61UMLS, 8Disease Ontology, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

villonodular synovitis 8
pigmented villonodular synovitis 61


External Ids:

Disease Ontology8 DOID:9898
ICD9CM27 719.20, 719.2
ICD1025 M12.2

Related Diseases for Villonodular Synovitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.3MMP1, CD68, TNFRSF11B, TNFSF11
2pigmented villonodular synovitis32.2LAPTM5, ANKLE2, ATP6V1B2, CSF1, CSF1R, PDGFRB
3arthritis30.8TNFRSF11B, TNFSF11, CSF1, CSF1R, BGLAP, MMP1
4osteonecrosis30.5BGLAP
5squamous cell carcinoma30.2IBSP, CSF1R, MMP1, MMP9, PTHLH, SPP1
6osteoarthritis30.2TNFSF11, CSF1, CSF1R, IBSP, BGLAP, TNFRSF11B
7tenosynovial giant cell tumor10.7
8synovial chondromatosis10.5
9synovitis, chronic10.4
10noonan syndrome10.3
11carpal tunnel syndrome10.3
12hemarthrosis10.3
13n syndrome10.3
14tuberculosis10.3
15chronic pain10.3
16chondroblastoma10.2
17nodular tenosynovitis10.2
18ulnar neuropathy10.2
19systemic lupus erythematosus10.2
20reactive arthritis10.2
21peroneal neuropathy10.2
22bone giant cell tumor10.2
23osteochondroma10.2
24soft tissue sarcoma10.2
25spastic paraparesis10.2
26congenital plasminogen deficiency10.2
27polyploidy10.2
28multicentric reticulohistiocytosis10.0CD68
29histiocytosis10.0CD68
30adenoma10.0PVR
31adult t-cell leukemia10.0PTHLH
32root resorption10.0TNFRSF11B
33endometriosis10.0MMP1
34cystic fibrosis10.0TNFRSF11B
35glomerulonephritis10.0SPP1
36myelofibrosis10.0PDGFRB
37leiomyosarcoma10.0PDGFRB
38arteriosclerosis10.0SPP1
39gastrointestinal stromal tumor10.0PDGFRB
40uterine sarcoma10.0PDGFRB
41multiple myeloma10.0TNFRSF11B, TNFSF11
42osteosclerosis10.0TNFRSF11B, TNFSF11
43periodontal disease10.0MMP1, TNFSF11
44nephrolithiasis10.0SPP1
45bronchopulmonary dysplasia10.0PTHLH
46paget disease, juvenile10.0TNFSF11, TNFRSF11B
47polyostotic osteolytic dysplasia, hereditary expansile10.0TNFSF11, TNFRSF11B
48severe combined immunodeficiency10.0CSF1
49dementia10.0TNFRSF11B
50hypertension10.0MMP9

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to villonodular synovitis

Clinical Features for Villonodular Synovitis

Drugs & Therapeutics for Villonodular Synovitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Villonodular Synovitis

Drug clinical trials:

Search ClinicalTrials for Villonodular Synovitis

Search NIH Clinical Center for Villonodular Synovitis

Search CenterWatch for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Villonodular Synovitis:

33
Lung, Skeletal muscle

Animal Models for Villonodular Synovitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Villonodular Synovitis

Sources:
51PubMed
See all sources

Articles related to Villonodular Synovitis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Pigmented villonodular synovitis great toe. (24426620)
2013
2
Post-traumatic haemorrhagic synovitis of knee mimicking pigmented villonodular synovitis. (23704440)
2013
3
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
4
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
5
Hemiarthroplasty in a patient with pigmented villonodular synovitis of the shoulder. (22229600)
2012
6
Intraarticular adalimumab in a patient with pigmented villonodular synovitis. (19820943)
2011
7
Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report. (21899757)
2011
8
Pigmented villonodular synovitis of the hip presenting as a buttock mass treated by total hip arthroplasty. (19056222)
2010
9
Pigmented villonodular synovitis: an overdiagnosed entity. (19817903)
2009
10
Simultaneous pigmented villonodular synovitis and synovial chondromatosis of the temporomandibular joint: case report. (19608385)
2009
11
Extra-articular pigmented villonodular synovitis of the subacromial space. (19226060)
2008
12
Villonodular synovitis in the dog: a report of four cases. (16810350)
2006
13
Pigmented villonodular synovitis of the hip mimicking soft-tissue sarcoma: a case report. (16598093)
2006
14
Surgical treatment of pigmented villonodular synovitis of the hip. (15866964)
2005
15
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
16
Pigmented villonodular synovitis of the foot and ankle. (15680105)
2004
17
Pigmented villonodular synovitis of the temporomandibular joint: differential diagnosis and case report. (14706302)
2004
18
Localized pigmented villonodular synovitis in an unusual location in the knee. (12579146)
2003
19
Pigmented villonodular synovitis of the temporomandibular joint: a report of two cases. (14569704)
2003
20
Recurrent and non-recurrent pigmented villonodular synovitis 1. (12594386)
2002
21
Pigmented villonodular synovitis. A literature review and unusual case report. (12471860)
2002
22
Invasive pigmented villonodular synovitis of the atlantoaxial joint: a case report. (12377919)
2002
23
Sweet's syndrome associated with pigmented villonodular synovitis. (11915462)
2002
24
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
25
Pigmented villonodular synovitis of lumbar facet joint: a rare cause of nerve root entrapment. (11413441)
2001
26
Patellar instability as a result of localized pigmented villonodular synovitis. (11703039)
2001
27
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
28
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
29
Pigmented villonodular synovitis of the hip and knee. (10524485)
1999
30
Pigmented villonodular synovitis of the subacromial bursa. (9285882)
1997
31
Pigmented villonodular synovitis and synovial chondromatosis arthroscopically diagnosed and treated in the same elbow. (9043614)
1997
32
Villonodular synovitis. (8751649)
1996
33
Polyarticular pigmented villonodular synovitis associated with multiple congenital anomalies. A case of Noonan-like/multiple giant cell lesion syndrome. (8737730)
1996
34
Pigmented villonodular synovitis of the spine: a clinical, radiological, and morphological study of 12 cases. (8613850)
1996
35
Progression from simple joint effusion to extensive pigmented villonodular synovitis of the hip within 2 years: demonstration with MR imaging. (7645515)
1995
36
Magnetic resonance imaging in the diagnosis of localized pigmented villonodular synovitis of the ankle: a case report. (7981807)
1994
37
Pigmented villonodular synovitis of the temporomandibular joint: report of a case. (8163924)
1994
38
Pigmented villonodular synovitis. (8402374)
1993
39
Pigmented villonodular synovitis of the knee in a patient with Paget's disease of the adjacent femoral bone. (8428233)
1993
40
Pigmented villonodular synovitis and synovial cysts of the spine [ comment]. (1595437)
1992
41
Pigmented villonodular synovitis presenting as a subcutaneous mass at the knee. (1629838)
1992
42
Pigmented villonodular synovitis. (2383449)
1990
43
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
44
Pigmented villonodular synovitis presenting as a large lateral knee mass. Case report and review of the literature. (3050804)
1988
45
Acute carpal tunnel syndrome caused by pigmented villonodular synovitis of the wrist. (3342575)
1988
46
Three cases of pigmented villonodular synovitis of the knee. Ultrasound and computed tomographic findings. (3018867)
1986
47
Pigmented villonodular synovitis of the wrist and adjacent bones. (3453479)
1986
48
Pigmented villonodular synovitis of the shoulder: radiologic-pathologic assessment. (6332500)
1984
49
Pigmented villonodular synovitis of the temporomandibular joint. (6641186)
1983
50
Pigmented villonodular synovitis of the temporomandibular joint. (6819533)
1982

Genetic Variations for Villonodular Synovitis

Expression for genes affiliated with Villonodular Synovitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for genes affiliated with Villonodular Synovitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Villonodular Synovitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24510.6MMP9
2procollagen4510.5TNFSF11, ACP5
3cycloheximide4510.4CSF1R, IBSP
4rantes4510.0CALCR, CSF1, ACP5
5indomethacin45 60 29 1113.0SPP1, CSF1
6estradiol45 11 2412.0IBSP, CALCR, PTHLH, ACP5
7matrigel459.9PTHLH, PDGFRB, MMP1, IBSP
8clodronate45 50 1111.8TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
9prostaglandin459.8TNFRSF11B, CSF1, TNFSF11, MMP1
10geranylgeranyl pyrophosphate459.7TNFSF11, TNFRSF11B, MMP9, MMP1
11etanercept45 50 1111.5TNFSF11, MMP1, CSF1, TNFRSF11B
12celecoxib45 60 29 50 11 2414.4MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
13ibandronate45 1110.4TNFSF11, TNFRSF11B, IBSP, BGLAP
14pyridinoline459.3ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
15deoxypyridinoline459.2TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
16vitamin k2459.2BGLAP, CSF1, TNFRSF11B, TNFSF11
17pamidronate45 50 1111.2MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
18alendronate45 50 1111.1BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
19tgf beta1459.1CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
20infliximab45 50 1111.1SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
21titanium459.0IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
22pd 98,059459.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
2325-hydroxyvitamin d459.0BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
24phosphorus459.0TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
25azathioprine45 50 2 1112.0TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
26tartrate458.9TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
27genistein45 29 60 2 11 2413.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
28troglitazone45 29 60 1111.8MMP1, SPP1, PTHLH, MMP9, CSF1
29hydroxyapatite458.8PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
30ns 39845 609.8MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
31hydroxyproline45 11 2410.7MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
32zoledronic acid458.7BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
33prednisolone45 29 1110.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
34heparin45 29 11 2411.6IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
35ascorbic acid45 249.6MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
36serine458.4MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
37phosphatidylinositol458.4CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
38sb 20358045 609.3SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
39cyclosporin a45 29 6010.3TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
40dexamethasone45 50 29 1111.2TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
41vitamin d458.1CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
421,25 dihydroxy vitamin d3458.0TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
43tyrosine458.0ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
44testosterone45 60 11 2411.0MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
45calcitriol45 60 11 2410.9BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
46retinoic acid45 248.8PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
47creatinine457.7TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
48cysteine457.6MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
49vegf457.6SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
50paraffin457.3PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP

GO Terms for genes affiliated with Villonodular Synovitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.4SPP1, BGLAP
2extracellular spaceGO:0056157.9SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
3extracellular regionGO:0055767.7BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.1TNFSF11, CSF1
2positive regulation of bone resorptionGO:04578010.0SPP1, TNFSF11
3osteoclast differentiationGO:0303169.9TNFSF11, CSF1, CSF1R
4phosphatidylinositol metabolic processGO:0464889.9CSF1R, PDGFRB
5macrophage differentiationGO:0302259.8MMP9, CSF1, CSF1R
6ossificationGO:0015039.8IBSP, CSF1, TNFSF11
7regulation of bone resorptionGO:0451249.5CSF1R, BGLAP
8extracellular matrix organizationGO:0301989.4IBSP, TNFRSF11B, MMP1, MMP9, SPP1
9response to vitamin DGO:0332809.1SPP1, BGLAP
10skeletal system developmentGO:0015019.1BGLAP, TNFRSF11B, MMP9, PTHLH

Molecular functions related to Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Villonodular Synovitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Villonodular Synovitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet