Aliases & Classifications for Villous Adenoma

MalaCards integrated aliases for Villous Adenoma:

Name: Villous Adenoma 12 14
Adenoma, Villous 69
Adenoma Villous 51

Classifications:



External Ids:

Disease Ontology 12 DOID:0050869
UMLS 69 C0206674

Summaries for Villous Adenoma

MalaCards based summary : Villous Adenoma, also known as adenoma, villous, is related to anal canal adenocarcinoma and adenoma. An important gene associated with Villous Adenoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Pathways in cancer and Development EGFR signaling pathway. The drugs Anti-Inflammatory Agents and Anti-Inflammatory Agents, Non-Steroidal have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and prostate, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Villous adenoma is a type of polyp that grows in the colon and other places in the gastrointestinal... more...

Related Diseases for Villous Adenoma

Diseases related to Villous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 anal canal adenocarcinoma 30.2 CDX2 KRAS
2 adenoma 30.2 BRAF GNAS KRAS SST
3 adenocarcinoma in situ 29.9 CDX2 KRAS KRT20
4 adenocarcinoma 29.8 BRAF KRAS MUC1
5 mucinous adenocarcinoma 29.6 CDX2 KRAS KRT20 MUC1
6 pseudomyxoma peritonei 29.2 CDX2 KRAS KRT20 MUC1
7 adenosquamous carcinoma 29.1 KRAS MUC1
8 colorectal adenocarcinoma 29.0 BRAF CDX2 KRAS KRT20
9 urinary bladder villous adenoma 12.1
10 urethral villous adenoma 12.1
11 vaginal villous adenoma 12.1
12 vaginal benign neoplasm 10.4 CDX2 KRT20
13 vaginal adenoma 10.4 CDX2 KRT20
14 vaginal tubulovillous adenoma 10.4 CDX2 KRT20
15 ovarian mucinous adenocarcinoma 10.4 CDX2 KRT20
16 thymus adenocarcinoma 10.4 CDX2 KRT20
17 gastric diffuse adenocarcinoma 10.4 CDX2 KRT20
18 vulva adenocarcinoma 10.4 CDX2 KRT20
19 jejunal adenocarcinoma 10.4 CDX2 KRT20
20 chronic cystitis 10.4 CDX2 KRT20
21 rectum adenocarcinoma 10.4 CDX2 KRT20
22 endocervical adenocarcinoma 10.4 CDX2 KRT20
23 seminal vesicle adenocarcinoma 10.4 KLK3 KRT20
24 bronchiolo-alveolar adenocarcinoma 10.4 CDX2 KRAS
25 ovarian mucinous neoplasm 10.4 CDX2 KRT20
26 horseshoe kidney 10.4 CDX2 KRT20
27 cystic teratoma 10.3 CDX2 KRT20
28 nasal cavity adenocarcinoma 10.3 CDX2 KRAS
29 prostatic acinar adenocarcinoma 10.3 KLK3 KRT20
30 rete testis adenocarcinoma 10.3 KLK3 KRT20
31 hormone producing pituitary cancer 10.3 GNAS SST
32 rete testis neoplasm 10.3 KLK3 KRT20
33 pituitary carcinoma 10.3 GNAS SST
34 adenoma of the pancreas 10.3 KRT20 SST
35 appendix adenocarcinoma 10.3 CDX2 KRT20
36 anus cancer 10.3 CDX2 KRAS
37 growth hormone secreting pituitary adenoma 10.3 GNAS SST
38 periampullary adenoma 10.3 KRAS SST
39 pancreatic intraductal papillary-mucinous neoplasm 10.3 GNAS MUC1
40 tumor of exocrine pancreas 10.3 GNAS MUC1
41 bile duct cystadenocarcinoma 10.2 KRT20 MUC1
42 gastrointestinal system benign neoplasm 10.2 CDX2 KRAS
43 paget disease, extramammary 10.2 KRT20 MUC1
44 mucinous cystadenocarcinoma 10.2 KRT20 MUC1
45 apocrine adenoma 10.2 KRAS MUC1
46 hepatoid adenocarcinoma 10.2 CDX2 MUC1
47 lymphoepithelioma-like carcinoma 10.2 KRT20 MUC1
48 prostatic hyperplasia, benign 10.2 FOLH1 KLK3
49 dermoid cyst 10.2 KRT20 MUC1
50 mucinous ovarian cystadenoma 10.2 CDX2 MUC1

Graphical network of the top 20 diseases related to Villous Adenoma:



Diseases related to Villous Adenoma

Symptoms & Phenotypes for Villous Adenoma

GenomeRNAi Phenotypes related to Villous Adenoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.36 BRAF KRAS MUC1
2 Decreased viability GR00106-A-0 9.36 KRAS
3 Decreased viability GR00221-A-1 9.36 KRAS
4 Decreased viability GR00221-A-2 9.36 KRAS
5 Decreased viability GR00221-A-4 9.36 BRAF
6 Decreased viability GR00301-A 9.36 BRAF KRAS
7 Decreased viability GR00381-A-1 9.36 KRAS BRAF

Drugs & Therapeutics for Villous Adenoma

Drugs for Villous Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Inflammatory Agents Phase 3
2 Anti-Inflammatory Agents, Non-Steroidal Phase 3
3 Cola Nutraceutical Phase 3,Phase 2
4
Epigallocatechin gallate Investigational Phase 2 989-51-5 65064
5
Catechin Nutraceutical Phase 2 154-23-4 9064
6
Epigallocatechin Experimental, Investigational, Nutraceutical Phase 2 970-74-1 72277
7
Epicatechin Investigational, Nutraceutical Phase 2 490-46-0 72276
8 Tea Nutraceutical Phase 2
9
Aspirin Approved, Vet_approved 50-78-2 2244
10
Midazolam Approved, Illicit 59467-70-8 4192
11
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) Withdrawn NCT01245816 Phase 3 Eflornithine plus Sulindac;Eflornithine plus Placebo;Sulindac plus Placebo
2 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
3 Complete Histologic Resection of Adenomatous Polyps? Completed NCT01224444
4 To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas Recruiting NCT02521727

Search NIH Clinical Center for Villous Adenoma

Genetic Tests for Villous Adenoma

Anatomical Context for Villous Adenoma

MalaCards organs/tissues related to Villous Adenoma:

38
Colon, Appendix, Prostate, Testes

Publications for Villous Adenoma

Articles related to Villous Adenoma:

(show top 50) (show all 68)
# Title Authors Year
1
A case of urachal villous adenoma with high grade dysplasia focally bordering on adenocarcinoma in situ. ( 29321972 )
2018
2
Endoanal resection of a giant villous adenoma in the middle rectum - Video Vignette. ( 29364560 )
2018
3
Robotic approach to resection of villous adenoma of the urachus: a case report and literature review. ( 28889213 )
2017
4
Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( 28188165 )
2017
5
A villous adenoma of bladder/urachus origin located in the perineum. ( 28727697 )
2017
6
Villous Adenoma in Renal Pelvis with Manifestation of Percutaneous Fistula and Mucus Secretion. ( 28069333 )
2017
7
Pure Villous Adenoma of the Vesicoureteric Junction Presenting as Pyonephrosis. ( 28969142 )
2017
8
Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report. ( 27121034 )
2016
9
Villous Adenoma of the Urinary Bladder: A Brief Review of the Literature. ( 26717061 )
2016
10
Common bile duct villous adenoma: a case report and review of the literature. ( 26795920 )
2016
11
Villous Adenoma Arising at the Hepaticojejunostomy Site (HJ Site): First Report of an Unusual Case. ( 27406827 )
2016
12
Poorly Differentiated Neuroendocrine Tumor of the Rectum Coexistent with Giant Rectal Villous Adenoma Presenting as McKittrick-Wheelock Syndrome. ( 26682079 )
2015
13
Large Tubullo-villous Adenoma of Duodenum Presenting as Gastric Outlet Obstruction. ( 26816945 )
2015
14
Intussusception by Villous Adenoma of the Appendix. ( 27011572 )
2015
15
Villous adenoma of the common hepatic duct: the importance of contrast-enhanced ultrasound and endoscopic retrograde cholangiopancreatography for relevant diagnosis. A case report and review of the literature. ( 26649355 )
2015
16
Concurrence of primary malignant melanoma of the esophagus with adenocarcinoma of sigmoid colon and villous adenoma of cecum: a case presentation. ( 26629222 )
2015
17
Villous adenoma of the urinary bladder. ( 26458700 )
2015
18
Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature. ( 26458689 )
2015
19
Giant villous adenoma of rectum mimicking an infiltrating adenocarcinoma. ( 26710491 )
2015
20
Villous adenoma in gallbladder volvulus: A rare coincidence. ( 25910354 )
2014
21
Mucinous adenocarcinoma of the umbilicus 8 years following anterior resection for villous adenoma of the rectum. ( 24876318 )
2014
22
Giant rectal villous adenoma: Surgical approach with rectal eversion and perianal coloanal anastomosis. ( 24441716 )
2014
23
Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma. ( 24470207 )
2014
24
Education and imaging: gastrointestinal: villous adenoma of the ampulla of Vater causing acute pancreatitis. ( 23339391 )
2013
25
Renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22934691 )
2013
26
Editorial Comment to renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22994387 )
2013
27
Recurrent pancreatitis caused by pancreatic ductal villous adenoma treated with endoscopic snare polypectomy. ( 23468150 )
2013
28
Intestinal type villous adenoma of the renal pelvis. ( 23671505 )
2013
29
Primary intestinal type adenocarcinoma of the female genital tract, arisen from a tubulo-villous adenoma: Case report. ( 24371679 )
2013
30
Large villous adenoma of gallbladder: A case report. ( 23276760 )
2013
31
Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome. ( 24199207 )
2013
32
A giant rectal villous adenoma with a malicious intent. ( 24312688 )
2013
33
Villous adenoma of the appendix: management recommendations. ( 23317609 )
2013
34
Acute renal failure and metabolic alkalosis in a patient with colorectal villous adenoma (McKittrick-Wheelock syndrome). ( 22749370 )
2013
35
Villous adenoma of duodenum: a rare case presentation with review of literature. ( 24426722 )
2013
36
Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report and review of the literature. ( 23870731 )
2013
37
McKittrick-Wheelock syndrome - Prolapsed giant villous adenoma of the rectum. ( 23971670 )
2013
38
Carpet villous adenoma of the rectum in an incarcerated rectal prolapse. ( 23923364 )
2012
39
Endoscopic ultrasound guided fine-needle aspiration diagnosis of duodenal high grade neuroendocrine carcinoma underlying a villous adenoma: report of a case. ( 22180240 )
2012
40
Frequent activating GNAS mutations in villous adenoma of the colorectum. ( 22374786 )
2012
41
'Volcano sign' and endoscopic mucosal resection of a villous adenoma arising from the appendix. ( 22387285 )
2012
42
Villous adenoma of gallbladder in a patient with systemic lupus erythematosus. ( 23798953 )
2012
43
Giant villous adenoma and McKittrick-Wheelock syndrome in an incarcerated rectal prolapse. ( 19220372 )
2010
44
Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. ( 20514431 )
2010
45
Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum. ( 19718251 )
2009
46
A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. ( 20182635 )
2009
47
Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. ( 18670358 )
2008
48
CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. ( 17950780 )
2008
49
Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. ( 18698690 )
2008
50
Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. ( 16450120 )
2006

Variations for Villous Adenoma

Cosmic variations for Villous Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM517 KRAS large intestine,colon,adenoma,villous c.34G>A p.G12S 11
2 COSM532 KRAS large intestine,colon,adenoma,villous c.38G>A p.G13D 11
3 COSM520 KRAS large intestine,colon,adenoma,villous c.35G>T p.G12V 11
4 COSM521 KRAS large intestine,colon,adenoma,villous c.35G>A p.G12D 11
5 COSM27895 GNAS large intestine,colon,adenoma,villous c.602G>A p.R201H 11
6 COSM27887 GNAS large intestine,colon,adenoma,villous c.601C>T p.R201C 11
7 COSM22971 FBXW7 large intestine,colon,adenoma,villous c.832C>T p.R278* 11
8 COSM476 BRAF large intestine,colon,adenoma,villous c.1799T>A p.V600E 11

Expression for Villous Adenoma

Search GEO for disease gene expression data for Villous Adenoma.

Pathways for Villous Adenoma

GO Terms for Villous Adenoma

Sources for Villous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....