MCID: VLL006
MIFTS: 32

Villous Adenoma malady

Categories: Cancer diseases

Aliases & Classifications for Villous Adenoma

Aliases & Descriptions for Villous Adenoma:

Name: Villous Adenoma 12 14
Adenoma, Villous 69
Adenoma Villous 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050869

Summaries for Villous Adenoma

MalaCards based summary : Villous Adenoma, also known as adenoma, villous, is related to vaginal villous adenoma and neuroendocrine tumor. An important gene associated with Villous Adenoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Glioma and Beta-Adrenergic Signaling. The drugs Celecoxib and Sulindac have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and prostate, and related phenotype is digestive/alimentary.

Wikipedia : 71 Villous adenoma is a type of polyp that grows in the colon and other places in the gastrointestinal... more...

Related Diseases for Villous Adenoma

Diseases related to Villous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 vaginal villous adenoma 32.8 CDX2 KRT8
2 neuroendocrine tumor 29.9 CDX2 KRT20
3 urinary bladder villous adenoma 12.0
4 urethral villous adenoma 12.0
5 adenoma 10.6
6 adenocarcinoma 10.3
7 peritoneal benign neoplasm 10.3 CDX2 KRT20
8 dystonia 10.3 CDX2 KRT20
9 anal canal paget's disease 10.3 CDX2 KRT20
10 clitoris cancer 10.3 CDX2 KRT20
11 cervix endometriosis 10.2 CDX2 KRT20
12 agenesis and aplasia of uterine body 10.2 KRAS KRT20
13 apocrine adenocarcinoma 10.2 CDX2 KRT20
14 steroid-induced glaucoma - borderline 10.2 KLK3 KRT20
15 uterine ligament mucinous adenocarcinoma 10.2 CDX2 KRAS
16 mucosal melanoma 10.2 CDX2 KRT20
17 neurofibrosarcoma 10.2 CDX2 KRT20
18 ureter adenocarcinoma 10.2 CDX2 KRAS
19 myotonia congenita 10.2 CDX2 KRT20
20 postpoliomyelitis syndrome 10.2 CDX2 KRAS
21 spastic ataxia 5 10.2 CDX2 KRT20
22 colon signet ring adenocarcinoma 10.2 KLK3 KRT20
23 cervical serous adenocarcinoma 10.2 GNAS KRAS
24 mesenchymoma 10.2 CDX2 KRT20
25 sphenoid sinus squamous cell carcinoma 10.2 KLK3 KRT20
26 uterine corpus endometrial stromal sarcoma 10.2 KRAS KRT20
27 hunter macpherson syndrome 10.2 CDX2 KRT20
28 sexual sadism 10.2 CDX2 KRT8
29 churg-strauss syndrome 10.2 CDX2 KRT20
30 spinal cord astrocytoma 10.1 BRAF GNAS
31 prostate lymphoma 10.1 KLK3 KRT8
32 pseudomonas stutzeri infections 10.1 BRAF KRAS
33 rdh12-related leber congenital amaurosis 10.1 BRAF KRAS
34 embryonal testis carcinoma 10.1 KRT20 KRT8
35 cranial nerve disease 10.1 KLK3 KRT20
36 wolffian duct adenoma 10.1 GNAS KRAS KRT20
37 biliary papillomatosis 10.1 BRAF KRAS
38 aicardi-goutieres syndrome 10.1 CDX2 KRAS
39 infantile thalamic degeneration 10.1 BRAF KRAS
40 parachordoma 10.1 BRAF KRAS
41 giant cell tumor 10.1 CDX2 KRAS KRT20
42 papillary adenofibroma 10.1 CDX2 KRAS KRT20
43 sagittal sinus thrombosis 10.1 CDX2 KRAS KRT20
44 meninges hemangiopericytoma 10.1 CDX2 KRAS KRT20
45 acute stress disorder 10.1 CDX2 KRAS KRT20
46 pacinian tumor 10.1 CDX2 KRT20
47 allergic contact dermatitis 10.1 CDX2 KRAS KRT20
48 advanced sleep phase syndrome 10.1 CDX2 KRAS KRT20
49 gastroesophageal junction adenocarcinoma 10.1 CDX2 KRAS KRT20
50 syndactyly-polydactyly-earlobe syndrome 10.1 BRAF KRAS

Graphical network of the top 20 diseases related to Villous Adenoma:



Diseases related to Villous Adenoma

Symptoms & Phenotypes for Villous Adenoma

MGI Mouse Phenotypes related to Villous Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 BRAF CDX2 KRAS KRT8 SST

Drugs & Therapeutics for Villous Adenoma

Drugs for Villous Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
2
Sulindac Approved Phase 3 38194-50-2 5352 1548887
3 Analgesics Phase 3
4 Analgesics, Non-Narcotic Phase 3
5 Anti-Inflammatory Agents Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Cyclooxygenase 2 Inhibitors Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Anti-Infective Agents Phase 3
12 Antiparasitic Agents Phase 3
13 Antiprotozoal Agents Phase 3
14 Cola Nutraceutical Phase 3,Phase 2
15
Ornithine Nutraceutical Phase 3 3184-13-2 6262 389
16
Epigallocatechin gallate Phase 2 989-51-5 65064
17
Catechin Nutraceutical Phase 2 154-23-4 9064
18
Epicatechin Nutraceutical Phase 2 490-46-0 72276
19
Epigallocatechin Experimental, Nutraceutical Phase 2 970-74-1 72277
20 Tea Nutraceutical Phase 2
21
Aspirin Approved, Vet_approved 50-78-2 2244
22
Menthol Approved 2216-51-5 16666
23
Meperidine Approved 57-42-1 4058
24
Midazolam Approved, Illicit 59467-70-8 4192

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps Completed NCT00005094 Phase 3
2 S0820, Adenoma and Second Primary Prevention Trial Recruiting NCT01349881 Phase 3
3 A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) Withdrawn NCT01245816 Phase 3
4 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Recruiting NCT01360320 Phase 2
5 Randomised Trial of NBI for Adenoma Detection Unknown status NCT00279357
6 Complete Histologic Resection of Adenomatous Polyps? Completed NCT01224444
7 Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs) Completed NCT01062035
8 Diagnosis of Colonic Adenomas by Bright Narrow Band Imaging (B-NBI) Completed NCT01422577
9 Outcomes of Endoscopic Resection of Mucosal and Submucosal Lesions in the Stomach Recruiting NCT02306707
10 Long-term Outcomes of Endoscopic Resection (ER) of Lesions of the Duodenum and Ampulla Recruiting NCT02306603
11 Upper GI Outcomes Following EMR Recruiting NCT02305290
12 To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas Recruiting NCT02521727
13 A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study) Recruiting NCT01593098
14 Volatile Markers in Digestive Cancer Recruiting NCT02332213
15 Non-invasive Risk Stratification of CR AMN/SSP Not yet recruiting NCT02476682

Search NIH Clinical Center for Villous Adenoma

Genetic Tests for Villous Adenoma

Anatomical Context for Villous Adenoma

MalaCards organs/tissues related to Villous Adenoma:

39
Colon, Appendix, Prostate, Testes

Publications for Villous Adenoma

Articles related to Villous Adenoma:

(show top 50) (show all 62)
id Title Authors Year
1
Villous Adenoma in Renal Pelvis with Manifestation of Percutaneous Fistula and Mucus Secretion. ( 28069333 )
2017
2
Villous Adenoma Arising at the Hepaticojejunostomy Site (HJ Site): First Report of an Unusual Case. ( 27406827 )
2016
3
Common bile duct villous adenoma: a case report and review of the literature. ( 26795920 )
2016
4
Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report. ( 27121034 )
2016
5
Villous Adenoma of the Urinary Bladder: A Brief Review of the Literature. ( 26717061 )
2016
6
Concurrence of primary malignant melanoma of the esophagus with adenocarcinoma of sigmoid colon and villous adenoma of cecum: a case presentation. ( 26629222 )
2015
7
Intussusception by Villous Adenoma of the Appendix. ( 27011572 )
2015
8
Poorly Differentiated Neuroendocrine Tumor of the Rectum Coexistent with Giant Rectal Villous Adenoma Presenting as McKittrick-Wheelock Syndrome. ( 26682079 )
2015
9
Villous adenoma of the common hepatic duct: the importance of contrast-enhanced ultrasound and endoscopic retrograde cholangiopancreatography for relevant diagnosis. A case report and review of the literature. ( 26649355 )
2015
10
Giant villous adenoma of rectum mimicking an infiltrating adenocarcinoma. ( 26710491 )
2015
11
Villous adenoma of the urinary bladder. ( 26458700 )
2015
12
Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature. ( 26458689 )
2015
13
Large Tubullo-villous Adenoma of Duodenum Presenting as Gastric Outlet Obstruction. ( 26816945 )
2015
14
Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma. ( 24470207 )
2014
15
Giant rectal villous adenoma: Surgical approach with rectal eversion and perianal coloanal anastomosis. ( 24441716 )
2014
16
Villous adenoma in gallbladder volvulus: A rare coincidence. ( 25910354 )
2014
17
Mucinous adenocarcinoma of the umbilicus 8 years following anterior resection for villous adenoma of the rectum. ( 24876318 )
2014
18
Education and imaging: gastrointestinal: villous adenoma of the ampulla of Vater causing acute pancreatitis. ( 23339391 )
2013
19
Acute renal failure and metabolic alkalosis in a patient with colorectal villous adenoma (McKittrick-Wheelock syndrome). ( 22749370 )
2013
20
Primary intestinal type adenocarcinoma of the female genital tract, arisen from a tubulo-villous adenoma: Case report. ( 24371679 )
2013
21
Villous adenoma of the appendix: management recommendations. ( 23317609 )
2013
22
Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report and review of the literature. ( 23870731 )
2013
23
Editorial Comment to renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22994387 )
2013
24
Villous adenoma of duodenum: a rare case presentation with review of literature. ( 24426722 )
2013
25
Large villous adenoma of gallbladder: A case report. ( 23276760 )
2013
26
Intestinal type villous adenoma of the renal pelvis. ( 23671505 )
2013
27
A giant rectal villous adenoma with a malicious intent. ( 24312688 )
2013
28
McKittrick-Wheelock syndrome - Prolapsed giant villous adenoma of the rectum. ( 23971670 )
2013
29
Renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22934691 )
2013
30
Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome. ( 24199207 )
2013
31
Recurrent pancreatitis caused by pancreatic ductal villous adenoma treated with endoscopic snare polypectomy. ( 23468150 )
2013
32
Villous adenoma of gallbladder in a patient with systemic lupus erythematosus. ( 23798953 )
2012
33
Frequent activating GNAS mutations in villous adenoma of the colorectum. ( 22374786 )
2012
34
Carpet villous adenoma of the rectum in an incarcerated rectal prolapse. ( 23923364 )
2012
35
'Volcano sign' and endoscopic mucosal resection of a villous adenoma arising from the appendix. ( 22387285 )
2012
36
Endoscopic ultrasound guided fine-needle aspiration diagnosis of duodenal high grade neuroendocrine carcinoma underlying a villous adenoma: report of a case. ( 22180240 )
2012
37
Giant villous adenoma and McKittrick-Wheelock syndrome in an incarcerated rectal prolapse. ( 19220372 )
2010
38
Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. ( 20514431 )
2010
39
A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. ( 20182635 )
2009
40
Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum. ( 19718251 )
2009
41
CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. ( 17950780 )
2008
42
Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. ( 18698690 )
2008
43
Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. ( 18670358 )
2008
44
Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. ( 16450120 )
2006
45
Adenosquamous carcinoma arising in villous adenoma from female vulvar urethra. ( 16553190 )
2006
46
[Small-cell rectal carcinoma coexisted with tubular-villous adenoma]. ( 17144530 )
2006
47
Mucinous adenocarcinoma with superficial stromal invasion and villous adenoma of urachal remnants: a case report. ( 12783975 )
2003
48
Soft-tissue images. Pseudomyxoma peritonei and villous adenoma of the appendix. ( 11939663 )
2002
49
Genetic alterations in poorly differentiated endocrine colon carcinomas developing in tubulo-villous adenomas: a report of two cases. ( 11787850 )
2001
50
Villous adenoma of the urinary tract: a report of 23 cases, including 8 with coexistent adenocarcinoma. ( 10403298 )
1999

Variations for Villous Adenoma

Cosmic variations for Villous Adenoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM520 KRAS large intestine,colon,adenoma,villous c.35G>T p.G12V 11
2 COSM532 KRAS large intestine,colon,adenoma,villous c.38G>A p.G13D 11
3 COSM521 KRAS large intestine,colon,adenoma,villous c.35G>A p.G12D 11
4 COSM517 KRAS large intestine,colon,adenoma,villous c.34G>A p.G12S 11
5 COSM27887 GNAS large intestine,colon,adenoma,villous c.601C>T p.R201C 11
6 COSM27895 GNAS large intestine,colon,adenoma,villous c.602G>A p.R201H 11
7 COSM22971 FBXW7 large intestine,colon,adenoma,villous c.832C>T p.R278* 11
8 COSM476 BRAF large intestine,colon,adenoma,villous c.1799T>A p.V600E 11

Expression for Villous Adenoma

Search GEO for disease gene expression data for Villous Adenoma.

Pathways for Villous Adenoma

GO Terms for Villous Adenoma

Biological processes related to Villous Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 8.62 BRAF KRAS

Sources for Villous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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