MCID: VPM001
MIFTS: 59

Vipoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Vipoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards: Vipoma, also known as pancreatic cholera, is related to pancreatic cholera and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are ADP signalling through P2Y purinoceptor 12 and G alpha (s) signalling events. The compounds mibg and helospectin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and lung, and related mouse phenotypes are cardiovascular system and reproductive system.

Wikipedia:65 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 36MESH via Orphanet, 63UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

vipoma 8 43 10 45 49
pancreatic cholera 49 62
pancreatic vipoma 43 62
malignant vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-producing tumor 43
vasoactive intestinal peptide-secreting tumor 8
watery diarrhea - hypokalemia - achlorhydria 49
watery diarrhea - hypokalemic alkalosis 49
vasoactive intestinal peptide tumor 43
diarrheogenic islet cell tumor 49
verner-morrison syndrome 49
vip- secreting tumor 8
vip-secreting tumor 49
vipoma, malignant 8
malignant vipoma 62
wdha syndrome 49


External Ids:

Disease Ontology8 DOID:5574
MeSH35 D003969
NCIt40 C26749
ICD10 via Orphanet26 E16.8
SNOMED-CT58 253005002
SNOMED-CT via Orphanet59 447643008, 253005002, 70091000 39998009, more
MESH via Orphanet36 D003969
UMLS via Orphanet63 C0011993

Related Diseases for Vipoma

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17GeneCards, 18GeneDecks
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Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera31.4SST, VIP
2cholera31.1CALCA, NTS, CXCR4, VIP, SCT
3pancreatitis31.0SCT, SST, SMAD4
4diarrhea30.4CHGA, VIP, GAST, CALCA, SST
5pheochromocytoma30.3SCT, VIP, CHGA, MSH2, MEN1, SST
6wdha syndrome30.3CALCA, SST, VIP
7neurofibromatosis30.2MEN1, MSH2, SST
8glucagonoma30.0SCT, GAST, GHRH, GH1, MEN1, SST
9ulcerative colitis30.0NTS, VIP, MSH2
10parathyroid adenoma30.0MEN1, CHGA, CALCA
11neuroendocrine tumor29.9CALCA, CHGA, SST, VIP, GHRH
12multiple endocrine neoplasia29.9VIP, GAST, CHGA, MEN1, CALCA
13paraganglioma29.9GAST, CHGA, SST, MEN1, CALCA
14hypercalcemia29.9GAST, CALCA, MEN1, SCT, CHGA
15carcinoid syndrome29.6GAST, CALCA, GH1, GHRH, NTS, MEN1
16adenoma29.4GAST, CALCA, SMAD4, SCT, CHGA, GH1
17pancreatic vasoactive intestinal peptide producing tumor10.6
18small intestinal vasoactive intestinal peptide producing tumor10.5
19large cell carcinoma10.4
20hepatitis10.3
21somatostatin analog10.2
22angiodysplasia10.1SST
23intestinal disease10.1SST
24pituitary hypoplasia10.1GHRH
25pernicious anemia10.1GAST
26acth-secreting pituitary adenoma10.1GH1
27hypoadrenalism10.1GH1
28cowden disease10.1SMAD4
29dumping syndrome10.1NTS, SST
30secretory diarrhea10.1
31steatorrhea10.1SST, SCT
32neuroblastoma10.1VIP, NTS
33islet cell tumor10.1SST, GAST
34gigantism10.1SST, GH1
35pancreatic endocrine tumors10.1
36duodenogastric reflux10.1GAST, NTS
37acromegaly10.1SST, GH1
38duodenal ulcer10.1GAST, SCT
39achalasia10.1GAST, VIP
40merkel cell carcinoma10.1CHGA, SST
41hyperinsulinemic hypoglycemia10.1GAST, SST
42cushing's syndrome10.1SST, GH1
43growth retardation-mild developmental delay-chronic hepatitis syndrome10.1GHRH, GH1
44acinar cell carcinoma10.1CHGA, GAST
45pancreatic ductal carcinoma10.1SMAD4, CHGA
46ganglioneuroma10.1CHGA, VIP
47gastritis10.1SCT, GAST
48gastrointestinal system disease10.1SCT, GAST
49esophagitis10.1GAST, NTS
50growth hormone deficiency10.1GHRH, GH1

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Symptoms for Vipoma

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Drugs & Therapeutics for Vipoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Vipoma

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Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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33MalaCards
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MalaCards organs/tissues related to Vipoma:

33
Pancreas, Liver, Lung, Colon

Animal Models for Vipoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Vipoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CXCR4, CALCA, CHGA, VIP, SMAD4, MEN1
2MP:00053898.1GH1, MEN1, SMAD4, GHRH, VIP, CHGA
3MP:00053797.9SMAD4, VIP, CHGA, GHRH, GH1, GAST
4MP:00020067.7GAST, CALCA, MEN1, MSH2, SMAD4
5MP:00053787.7GH1, SMAD4, CHGA, CXCR4, SST, MEN1
6MP:00053817.6SMAD4, CXCR4, MSH2, SST, MEN1, GAST
7MP:00053877.1GAST, GHRH, MEN1, SST, CXCR4, VIP
8MP:00036316.8CALCA, SMAD4, SCT, CXCR4, MSH2, MEN1
9MP:00107686.4MSH2, CHGA, VIP, SMAD4, MEN1, CALCA
10MP:00053765.5SMAD4, VIP, CHGA, GAST, CALCA, GH1

Publications for Vipoma

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Sources:
52PubMed
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Articles related to Vipoma:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
VIPoma in a 37-year-old man. (23993192)
2013
2
A rare cause of diarrhea: pancreatic VIPoma. (24008482)
2013
3
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
4
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
5
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
6
Benign pancreatic vipoma. (21526882)
2011
7
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
8
VIPoma syndrome: challenges in management. (20730389)
2010
9
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
10
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
11
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
12
Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]. (17292846)
2007
13
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
14
Radiofrequency ablation has a valuable therapeutic role in metastatic VIPoma. (16354964)
2006
15
Calcitonin-secreting VIPoma. (16416161)
2005
16
VIPomas: an update in diagnosis and management in a series of 11 patients. (16001675)
2005
17
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
18
Jejunal vipoma]. (15646540)
2004
19
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
20
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
21
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
22
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
23
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
24
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
25
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
26
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
27
Ondansetron and VIPoma. (8392671)
1993
28
Primary hepatic vipoma. (8389095)
1993
29
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
30
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
31
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
32
The somatostatin analog SMS 201-995 in long-term treatment of vipoma]. (2177234)
1990
33
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
34
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
35
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
36
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
37
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
38
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
39
VIPoma syndrome. (2820063)
1987
40
VIPoma syndrome. (3035922)
1987
41
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
42
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
43
Chronic diarrhea due to VIPoma in two children. (6319655)
1984
44
Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene. (6139527)
1983
45
Resolution of recurrent Verner-Morrison syndrome by resection of metastatic vipoma. (6297109)
1983
46
Vipoma. (6294887)
1982
47
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
48
A renal vipoma. (7437784)
1980
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Variations for Vipoma

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Expression for genes affiliated with Vipoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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50PathCards, 55Reactome, 60Thomson Reuters, 53QIAGEN, 51PharmGKB, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Vipoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SCT, CALCA, GHRH
29.2CALCA, GHRH, VIP, SCT
3
Show member pathways
7.5NTS, SSTR3, SST, CXCR4, GHRH, GH1
4
Show member pathways
5.7GAST, SMAD4, SCT, VIP, CXCR4, SST

Compounds for genes affiliated with Vipoma

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1mibg459.5VIP, CALCA, SST, CHGA
2helospectin459.5VIP, SCT, CALCA
3naloxone45 29 51 1112.4NTS, GH1, GHRH, SST, VIP
4secretoneurin459.3SCT, CHGA, VIP
5sumatriptan45 29 61 51 24 1114.3GHRH, VIP, GH1, CALCA
6loxiglumide459.2SCT, NTS, GAST, SST
7levodopa45 1110.2SST, NTS, GHRH, GH1, CHGA
8lanreotide45 2910.1CHGA, SST, SSTR3, GHRH, GH1
95-hydroxyindoleacetic acid45 2410.1GAST, SST, CHGA, VIP
10minigastrin459.1VIP, SST, GAST
11lafutidine459.0CALCA, SST, SCT, GAST
12pirenzepine45 29 1111.0GAST, SST, GHRH, GH1
13ibmx45 61 2910.9CALCA, SST, VIP, GH1, SCT
14guanine45 24 1110.8CALCA, VIP, SCT, NTS, CHGA, GH1
15omeprazole45 51 29 24 1112.8SCT, CHGA, SST, GAST
16oxyntomodulin45 619.7GAST, NTS, SST, SCT, VIP, CHGA
17clonidine45 51 29 1111.7CALCA, GH1, GHRH, NTS, SST, CHGA
18carbachol45 29 1110.6CHGA, NTS, SST, VIP, SCT, GAST
19forskolin45 51 1110.6GH1, CALCA, VIP, GHRH, CHGA, SCT
20gaba458.5GAST, NTS, SST, SCT, VIP, CHGA
21c-peptide458.5CHGA, GH1, GAST, NTS, SST, SCT
22corticosterone45 61 2410.5VIP, NTS, GH1, CALCA, GAST
235-hydroxytryptamine458.4VIP, CALCA, GAST, SST, CHGA, NTS
24nifedipine45 29 51 1111.3GAST, GH1, GHRH, NTS, SST, VIP
25lactate458.3SST, CALCA, CHGA, GH1, VIP, SMAD4
26acth458.1GHRH, GAST, GH1, NTS, SST, CHGA
27thymidine45 249.0MEN1, SMAD4, GAST, GH1, NTS, VIP
28vitamin d458.0GH1, CHGA, GAST, MEN1, GHRH, CALCA
29gnrh458.0SST, GHRH, VIP, NTS, GAST, GH1
30pge2457.9CALCA, SST, NTS, VIP, GAST, SCT
31atropine45 29 119.9GAST, CALCA, GHRH, NTS, SST, VIP
32thyroxine45 248.9CALCA, VIP, SST, NTS, SCT, GH1
33propranolol45 29 51 24 1111.9SST, GHRH, GH1, CALCA, GAST, VIP
34isoproterenol45 118.8SCT, CHGA, SST, GH1, CALCA, GAST
35acetylcholine45 51 29 24 1111.8GAST, SCT, VIP, CHGA, SST, CALCA
36dexamethasone45 51 29 1110.7CXCR4, GH1, GAST, GHRH, NTS, SST
37histamine45 29 249.7VIP, GAST, CALCA, NTS, SCT, SST
38norepinephrine45 24 119.6GHRH, GH1, CALCA, GAST, CHGA, NTS
39dopamine45 29 24 1110.6CHGA, GAST, CALCA, GH1, NTS, GHRH
40arginine457.4MSH2, SMAD4, SCT, VIP, CHGA, NTS
41glucose457.3GH1, NTS, GAST, CHGA, SST, CXCR4
42epinephrine45 24 119.3SCT, VIP, CHGA, SST, GAST, CALCA
43vegf457.1CHGA, MEN1, GH1, CALCA, SMAD4, VIP
44estrogen457.1GH1, SMAD4, GHRH, CALCA, GAST, MEN1
45octreotide45 61 29 1110.1SCT, GAST, CALCA, VIP, CHGA, SST
46adenylate457.1GAST, CALCA, GH1, GHRH, NTS, SST
47tyrosine457.0GAST, GH1, NTS, MEN1, SMAD4, CXCR4
48glutamate456.8CXCR4, GAST, CALCA, GHRH, NTS, SST
49testosterone45 61 24 119.7SMAD4, SCT, VIP, CHGA, CXCR4, SST
50serine456.4SMAD4, MEN1, SCT, VIP, CHGA, CXCR4

GO Terms for genes affiliated with Vipoma

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16Gene Ontology
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Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5CALCA, SST, VIP
2terminal boutonGO:0431959.5CALCA, GHRH
3extracellular regionGO:0055767.1GAST, SCT, VIP, CHGA, SST, NTS

Biological processes related to Vipoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GHRH, GH1
2hormone-mediated apoptotic signaling pathwayGO:0086289.9SST, SSTR3
3positive regulation of vasodilationGO:0459099.8CALCA, VIP
4positive regulation of multicellular organism growthGO:0400189.8GH1, GHRH
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.8MEN1, SMAD4
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, GHRH
7positive regulation of cAMP biosynthetic processGO:0308199.5GHRH, CALCA
8germ cell developmentGO:0072819.2MSH2, CXCR4
9cell-cell signalingGO:0072679.2CALCA, SST, SSTR3, GHRH
10negative regulation of cell proliferationGO:0082859.1SMAD4, SST, SSTR3, MEN1
11G-protein coupled receptor signaling pathwayGO:0071868.8GAST, VIP, CXCR4, SST

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.9VIP, NTS
2Y-form DNA bindingGO:0004039.5MSH2, MEN1
3R-SMAD bindingGO:0704129.4MEN1, SMAD4
4four-way junction DNA bindingGO:0004009.3MEN1, MSH2
5hormone activityGO:0051798.2SCT, VIP, SST, GH1, CALCA, GAST
6protein bindingGO:0055155.9MEN1, NTS, GH1, CALCA, MSH2, CXCR4

Products for genes affiliated with Vipoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vipoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet