MCID: VPM001
MIFTS: 57

Vipoma malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Vipoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards: Vipoma, also known as pancreatic cholera, is related to pancreatic cholera and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Class A/1 (Rhodopsin-like receptors). The compounds pge2 and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and lung, and related mouse phenotypes are nervous system and endocrine/exocrine gland.

Wikipedia:63 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

vipoma 8 42 10 44 48
pancreatic cholera 48 60
pancreatic vipoma 42 60
malignant vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-producing tumor 42
watery diarrhea - hypokalemia - achlorhydria 48
watery diarrhea - hypokalemic alkalosis 48
vasoactive intestinal peptide tumor 42
diarrheogenic islet cell tumor 48
verner-morrison syndrome 48
vip- secreting tumor 8
vip-secreting tumor 48
vipoma, malignant 8
malignant vipoma 60
wdha syndrome 48


External Ids:

Disease Ontology8 DOID:5574
NCIt39 C26749
MeSH34 D003969
SNOMED-CT56 253005002
ICD10 via Orphanet26 E16.8
SNOMED-CT via Orphanet57 447643008, 253005002, 70091000 39998009, more
MESH via Orphanet35 D003969

Related Diseases for Vipoma

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17GeneCards, 18GeneDecks
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Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera31.2PPY, VIP, SST
2cholera31.1CALCA, VIP, SCT, CXCR4, NTS
3pancreatitis30.8SST, SMAD4, PPY, SCT
4pheochromocytoma30.4VIP, CALCA, SST, NTS, SCT, MSH2
5diarrhea30.4SST, CALCA, VIP, CHGA, GAST, PPY
6wdha syndrome30.3SST, CALCA, VIP
7neurofibromatosis30.0MSH2, SST, MEN1
8ganglioneuroblastoma29.9VIP
9hypertension29.9CALCA
10parathyroid adenoma29.8CHGA, MEN1, CALCA
11paraganglioma29.8SST, CALCA, CHGA, MEN1, GAST
12hypercalcemia29.8SCT, GAST, CHGA, MEN1, CALCA
13lung small cell carcinoma29.8MEN1, CALCA, SCT, GAST, CHGA, SST
14neuroendocrine tumor29.8CHGA, GH1, MEN1, GAST, SCT, NTS
15adenocarcinoma29.8MSH2, VIP, SMAD4, SCT, GAST, MEN1
16adenoma29.8CALCA, MSH2, SMAD4, CXCR4, SSTR3, SCT
17pancreatic vasoactive intestinal peptide producing tumor10.6
18small intestinal vasoactive intestinal peptide producing tumor10.5
19large cell carcinoma10.3
20hepatitis10.2
21hepatitis a10.1
22secretory diarrhea10.1
23duodenal neoplasm10.0SST
24cholelithiasis10.0SST
25constipation10.0VIP
26hirschsprung's disease10.0VIP
27parkinson's disease10.0NTS
28duodenitis10.0GAST
29dyspepsia10.0GAST
30gastroduodenitis10.0GAST
31fibrous dysplasia10.0GH1
32essential hypertension10.0NTS
33gastric ulcer10.0GAST
34angiodysplasia10.0SST
35prader-willi syndrome10.0GH1
36acth-secreting pituitary adenoma10.0GH1
37panic disorder10.0GHRH
38lung cancer10.0CHGA, SST
39von hippel-lindau disease10.0MEN1
40galactosemia10.0SST
41neuroblastoma10.0VIP, NTS
42dumping syndrome10.0NTS, SST
43hypoadrenalism10.0GH1
44pernicious anemia10.0GAST
45esophagitis10.0GAST, NTS
46sarcoma10.0MSH2
47deficiency anemia10.0SMAD4, GHRH
48hypothyroidism10.0GH1, GHRH
49parathyroid carcinoma10.0MEN1
50anorexia nervosa10.0GHRH, GH1

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Clinical Features for Vipoma

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Drugs & Therapeutics for Vipoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Vipoma

Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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32MalaCards
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MalaCards organs/tissues related to Vipoma:

32
Pancreas, Liver, Lung, Colon

Animal Models for Vipoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.5SCT, GHRH, GH1, NTS
2MP:00053799.1GAST, MEN1, GHRH
3MP:00053898.7VIP, MEN1, GHRH, GH1, SMS, SMAD4
4MP:00053818.2SMAD4, MSH2, CXCR4, MEN1, GAST
5MP:00053767.5CXCR4, VIP, CALCA, SCT, GAST, MEN1
6MP:00053867.3VIP, CALCA, SCT, PPY, NTS, SST
7MP:00053877.2VIP, GAST, MEN1, GHRH, SST, CXCR4
8MP:00053786.9PPY, MEN1, GHRH, GH1, CHGA, NTS

Publications for Vipoma

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Sources:
50PubMed
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Articles related to Vipoma:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Sunitinib for the treatment of metastatic paraganglioma and vasoactive intestinal polypeptide-producing tumor (VIPoma). (23407483)
2013
2
Ischemic stroke as a presenting feature of VIPoma due to MEN 1 syndrome. (24251163)
2013
3
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
4
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
5
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
6
Benign pancreatic vipoma. (21526882)
2011
7
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
8
VIPoma syndrome: challenges in management. (20730389)
2010
9
Amelioration of symptoms and reduction of VIP levels after hepatic artery chemoembolization in a patient with sandostatin resistant VIPoma. (20351979)
2010
10
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
11
VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome. (19184565)
2009
12
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
13
Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]. (17292846)
2007
14
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
15
Calcitonin-secreting VIPoma. (16416161)
2005
16
Jejunal vipoma]. (15646540)
2004
17
VIPoma. (15590967)
2004
18
VIPoma: a rare cause of a pancreatic mass. (15162993)
2004
19
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
20
Metastatic pancreatic VIPoma: deteriorating clinical course and successful treatment by liver transplantation. (9577908)
1998
21
MR imaging of metastatic pancreatic VIPoma. (9408142)
1997
22
Massive amyloid deposition in pancreatic vipoma: a case report. (9007963)
1996
23
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
24
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
25
Liver VIPoma: report of two cases and literature review. (7950821)
1994
26
Stimulation of vasoactive intestinal peptide and neurotensin secretion by pentagastrin in a patient with VIPoma syndrome. (8128360)
1994
27
Ondansetron and VIPoma. (8392671)
1993
28
Primary hepatic vipoma. (8389095)
1993
29
Long-term therapy of a metastasizing pancreatic vipoma using the somatostatin derivative octreotide]. (1326786)
1992
30
VIPoma: surgical treatment]. (1314346)
1992
31
Giant metastatic VIPoma in the liver. (1655553)
1991
32
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
33
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
34
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
35
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
36
MR, CT, and ultrasound findings of metastatic vipoma in pancreas. (2562961)
1989
37
Metastatic vipoma arising from colonic primary tumour. (2547666)
1989
38
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
39
VIPoma syndrome. (3035922)
1987
40
Resection of a vipoma of the pancreas in a 15-year-old girl. (3025400)
1986
41
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
42
Long-term treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases. (2856877)
1985
43
Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene. (6139527)
1983
44
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
45
Loperamide therapy in a child with vipoma-associated diarrhoea. (6123702)
1982
46
Clinicopathological study of pancreatic and ganglioneuroblastoma tumours secreting vasoactive intestinal polypeptide (vipomas). (6786616)
1981
47
Presacral vipoma in a 16-month-old child. (6278821)
1981
48
A renal vipoma. (7437784)
1980
49
Cure of intractable watery diarrhoea by excision of a vipoma. (638444)
1978
50
The VIPoma: further confirmation of VIP as the hormonal agent in the WDHA syndrome. (998869)
1976

Genetic Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Vipoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1pge24410.5SST
2forskolin44 49 1111.9SCT, CALCA, GHRH
3bromocriptine28 44 1111.8SST, GHRH, VIP
4dexamethasone44 49 28 1112.7NTS, GH1, VIP, GHRH
5secretoneurin449.7VIP, CHGA, SCT
6mibg449.7SST, CALCA, VIP, CHGA
7helospectin449.7SCT, CALCA, VIP
8minigastrin449.6SST, VIP, GAST
9naloxone44 49 28 1112.6GHRH, NTS, GH1, VIP, SST
10sumatriptan44 28 59 49 11 2414.5VIP, GH1, CALCA, GHRH
11glutamate449.5GHRH, SCT, GAST, NTS
12loxiglumide449.5SST, NTS, GAST, SCT
135-hydroxyindoleacetic acid44 2410.4CHGA, VIP, GAST, SST
14pirenzepine44 28 1111.4GHRH, SST, GAST, GH1
15levodopa44 1110.4NTS, GHRH, GH1, SST, CHGA
16lafutidine449.3GAST, SCT, SST, CALCA
17lanreotide44 2810.3SST, GHRH, SSTR3, CHGA, GH1
18111in-pentetreotide449.3SST, CHGA, CALCA
19omeprazole44 28 49 11 2413.2GAST, CHGA, SST, SCT
20glucose449.1SCT, GAST, NTS, GHRH, SMAD4
21guanine44 11 2411.0CHGA, NTS, GH1, VIP, CALCA, SCT
22oxyntomodulin44 5910.0SST, NTS, VIP, GAST, CHGA, SCT
23dopamine44 28 11 2412.0GAST, GHRH, CHGA, NTS, SCT, VIP
24carbachol44 28 1111.0SCT, GAST, SST, VIP, NTS, CHGA
25ibmx44 28 5910.9GH1, VIP, CALCA, SST, SCT
26clonidine44 28 1110.9NTS, CALCA, SCT, GHRH, GH1, SST
27c-peptide448.9SCT, NTS, GH1, CHGA, SST, GAST
28gaba448.9NTS, CHGA, GAST, VIP, SST, SCT
29norepinephrine44 11 2410.9NTS, CHGA, GHRH, GAST, CALCA, VIP
30corticosterone44 59 2410.9GAST, GH1, CALCA, NTS, VIP
31atropine44 28 1110.8CALCA, SCT, GAST, GHRH, GH1, NTS
325-hydroxytryptamine448.8CALCA, CHGA, NTS, GAST, VIP, SST
33nifedipine44 49 28 1111.7GH1, GHRH, GAST, NTS, VIP, CHGA
34gnrh448.6NTS, CHGA, GH1, GHRH, GAST, VIP
35lactate448.5CHGA, SMAD4, GH1, CALCA, SST, VIP
36acth448.5GHRH, GH1, NTS, SST, CHGA, GAST
37serine448.3VIP, MEN1, SCT, GH1, NTS, MSH2
38propranolol44 28 49 11 2412.3GAST, CALCA, GHRH, GH1, CHGA, SST
39thyroxine44 249.3SST, GH1, GHRH, NTS, GAST, SCT
40vitamin d448.3CHGA, CALCA, MEN1, GAST, GH1, GHRH
41thymidine44 249.3VIP, SCT, SMAD4, NTS, GH1, GAST
42isoproterenol44 119.3GAST, SST, SCT, NTS, CHGA, GH1
43acetylcholine44 49 28 11 2412.3VIP, GAST, GH1, CHGA, NTS, CALCA
44histamine44 28 2410.1GAST, CXCR4, SST, NTS, CHGA, VIP
45epinephrine44 11 249.8CXCR4, SST, NTS, CHGA, GH1, GAST
46arginine447.8NTS, SST, CXCR4, MSH2, GHRH, SCT
47vegf447.6MEN1, GAST, VIP, CALCA, SMAD4, GH1
48adenylate447.6CHGA, NTS, CALCA, GHRH, VIP, SST
49octreotide44 59 28 1110.6SCT, GAST, GHRH, CHGA, CALCA, VIP
50testosterone44 59 11 2410.3VIP, CALCA, SCT, GAST, GHRH, SMAD4

GO Terms for genes affiliated with Vipoma

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16Gene Ontology
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Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.8SST, CALCA, SCT, PPY, GAST, GHRH

Biological processes related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:0086289.8SSTR3, SST
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6GH1, GHRH
3cell-cell signalingGO:0072679.1SSTR3, SST, GHRH, CALCA
4negative regulation of cell proliferationGO:0082859.0SMAD4, SSTR3, SST, MEN1
5G-protein coupled receptor signaling pathwayGO:0071868.8VIP, GAST, SST, CXCR4

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1R-SMAD bindingGO:0704129.8SMAD4, MEN1
2four-way junction DNA bindingGO:0004009.5MSH2, MEN1
3Y-form DNA bindingGO:0004039.3MSH2, MEN1
4hormone activityGO:0051797.6SST, VIP, CALCA, SCT, PPY, GAST

Products for genes affiliated with Vipoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet