MCID: VPM001
MIFTS: 57

Vipoma malady

Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Vipoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards: Vipoma, also known as pancreatic cholera, is related to pancreatic cholera and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Class A/1 (Rhodopsin-like receptors). The compounds pge2 and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are nervous system and endocrine/exocrine gland.

Wikipedia:63 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

vipoma 8 42 10 44 48
pancreatic cholera 48 60
pancreatic vipoma 42 60
malignant vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-producing tumor 42
watery diarrhea - hypokalemia - achlorhydria 48
watery diarrhea - hypokalemic alkalosis 48
vasoactive intestinal peptide tumor 42
diarrheogenic islet cell tumor 48
verner-morrison syndrome 48
vip- secreting tumor 8
vip-secreting tumor 48
vipoma, malignant 8
malignant vipoma 60
wdha syndrome 48


External Ids:

Disease Ontology8 DOID:5574
NCIt39 C26749
MeSH34 D003969
SNOMED-CT56 253005002
ICD10 via Orphanet26 E16.8
SNOMED-CT via Orphanet57 447643008, 253005002, 70091000 39998009, more
MESH via Orphanet35 D003969

Related Diseases for Vipoma

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17GeneCards, 18GeneDecks
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Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera31.2PPY, VIP, SST
2cholera31.1CALCA, VIP, SCT, CXCR4, NTS
3pancreatitis30.8SST, SMAD4, PPY, SCT
4pheochromocytoma30.4VIP, CALCA, SST, NTS, SCT, MSH2
5diarrhea30.4SST, CALCA, VIP, CHGA, GAST, PPY
6wdha syndrome30.3SST, CALCA, VIP
7neurofibromatosis30.0MSH2, SST, MEN1
8ganglioneuroblastoma29.9VIP
9hypertension29.9CALCA
10parathyroid adenoma29.8CHGA, MEN1, CALCA
11paraganglioma29.8SST, CALCA, CHGA, MEN1, GAST
12hypercalcemia29.8SCT, GAST, CHGA, MEN1, CALCA
13lung small cell carcinoma29.8MEN1, CALCA, SCT, GAST, CHGA, SST
14neuroendocrine tumor29.8CHGA, GH1, MEN1, GAST, SCT, NTS
15adenocarcinoma29.8MSH2, VIP, SMAD4, SCT, GAST, MEN1
16adenoma29.8CALCA, MSH2, SMAD4, CXCR4, SSTR3, SCT
17pancreatic vasoactive intestinal peptide producing tumor10.6
18small intestinal vasoactive intestinal peptide producing tumor10.5
19large cell carcinoma10.3
20hepatitis10.2
21hepatitis a10.1
22secretory diarrhea10.1
23duodenal neoplasm10.0SST
24cholelithiasis10.0SST
25constipation10.0VIP
26hirschsprung's disease10.0VIP
27parkinson's disease10.0NTS
28duodenitis10.0GAST
29dyspepsia10.0GAST
30gastroduodenitis10.0GAST
31fibrous dysplasia10.0GH1
32essential hypertension10.0NTS
33gastric ulcer10.0GAST
34angiodysplasia10.0SST
35prader-willi syndrome10.0GH1
36acth-secreting pituitary adenoma10.0GH1
37panic disorder10.0GHRH
38lung cancer10.0CHGA, SST
39von hippel-lindau disease10.0MEN1
40galactosemia10.0SST
41neuroblastoma10.0VIP, NTS
42dumping syndrome10.0NTS, SST
43hypoadrenalism10.0GH1
44pernicious anemia10.0GAST
45esophagitis10.0GAST, NTS
46sarcoma10.0MSH2
47deficiency anemia10.0SMAD4, GHRH
48hypothyroidism10.0GH1, GHRH
49parathyroid carcinoma10.0MEN1
50anorexia nervosa10.0GHRH, GH1

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Clinical Features for Vipoma

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Drugs & Therapeutics for Vipoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Vipoma

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Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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32MalaCards
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MalaCards organs/tissues related to Vipoma:

32
Pancreas, Liver, Colon, Lung

Animal Models for Vipoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Vipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.5SCT, GHRH, GH1, NTS
2MP:00053799.1GAST, MEN1, GHRH
3MP:00053898.7VIP, MEN1, GHRH, GH1, SMS, SMAD4
4MP:00053818.2SMAD4, MSH2, CXCR4, MEN1, GAST
5MP:00053767.5CXCR4, VIP, CALCA, SCT, GAST, MEN1
6MP:00053867.3VIP, CALCA, SCT, PPY, NTS, SST
7MP:00053877.2VIP, GAST, MEN1, GHRH, SST, CXCR4
8MP:00053786.9PPY, MEN1, GHRH, GH1, CHGA, NTS

Publications for Vipoma

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Sources:
50PubMed
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Articles related to Vipoma:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
VIPoma in a 37-year-old man. (23993192)
2013
2
Sunitinib for the treatment of metastatic paraganglioma and vasoactive intestinal polypeptide-producing tumor (VIPoma). (23407483)
2013
3
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
4
Is radiofrequency ablation justified for liver metastatic VIPoma patient undergoing Whipple procedure? (20819560)
2010
5
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
6
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
7
Radiofrequency ablation has a valuable therapeutic role in metastatic VIPoma. (16354964)
2006
8
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
9
Jejunal vipoma]. (15646540)
2004
10
VIPoma. (15590967)
2004
11
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
12
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
13
Vipoma: effective treatment with octreotide in the oldest old. (11347804)
2001
14
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
15
VIPoma of pancreas in a child. (11059195)
2000
16
Long-term survival after diagnosis of hepatic metastatic VIPoma: report of two cases with disparate courses and review of therapeutic options. (10389687)
1999
17
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
18
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
19
Location of a VIPoma by iodine-123-vasoactive intestinal peptide scintigraphy. (9744346)
1998
20
Pathophysiology and management of VIPoma: a case study. (8829164)
1996
21
Massive amyloid deposition in pancreatic vipoma: a case report. (9007963)
1996
22
Metastasizing pancreatic vipoma. Its diagnosis and therapy with the somatostatin analog octreotide]. (7588006)
1995
23
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
24
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
25
Ondansetron and VIPoma. (8392671)
1993
26
Calcitonin, as SMS 201-995, ameliorates the VIPoma syndrome. (8383153)
1993
27
Long-term therapy of a metastasizing pancreatic vipoma using the somatostatin derivative octreotide]. (1326786)
1992
28
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
29
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
30
The somatostatin analog SMS 201-995 in long-term treatment of vipoma]. (2177234)
1990
31
Treatment of metastatic Vipoma by liver transplantation. (10150088)
1990
32
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
33
Vipoma syndrome simultaneously occurring with small-cell carcinoma of the lung. (2541667)
1989
34
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
35
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
36
Successful treatment of a VIPoma by continuous subcutaneous infusion of somatostatin analogue (SMS 201-995). (2856504)
1988
37
VIPoma syndrome. (2820063)
1987
38
Escape of the response to a long-acting somatostatin analogue (SMS 201-995) in patients with VIPoma. (2878857)
1987
39
Resection of a vipoma of the pancreas in a 15-year-old girl. (3025400)
1986
40
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
41
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
42
Chronic diarrhea due to VIPoma in two children. (6319655)
1984
43
Vipoma. (6294887)
1982
44
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
45
Vipoma and watery diarrhea. (6283355)
1982
46
Presacral vipoma in a 16-month-old child. (6278821)
1981
47
Localisation of vipoma. (427420)
1979
48
Vipoma of the pancreas: observations on the diarhrhea and circulatory disturbances. (435002)
1979
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Genetic Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Vipoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1pge24410.5SST
2forskolin44 49 1111.9SCT, CALCA, GHRH
3bromocriptine28 44 1111.8SST, GHRH, VIP
4dexamethasone44 49 28 1112.7NTS, GH1, VIP, GHRH
5secretoneurin449.7VIP, CHGA, SCT
6mibg449.7SST, CALCA, VIP, CHGA
7helospectin449.7SCT, CALCA, VIP
8minigastrin449.6SST, VIP, GAST
9naloxone44 49 28 1112.6GHRH, NTS, GH1, VIP, SST
10sumatriptan44 28 59 49 11 2414.5VIP, GH1, CALCA, GHRH
11glutamate449.5GHRH, SCT, GAST, NTS
12loxiglumide449.5SST, NTS, GAST, SCT
135-hydroxyindoleacetic acid44 2410.4CHGA, VIP, GAST, SST
14pirenzepine44 28 1111.4GHRH, SST, GAST, GH1
15levodopa44 1110.4NTS, GHRH, GH1, SST, CHGA
16lafutidine449.3GAST, SCT, SST, CALCA
17lanreotide44 2810.3SST, GHRH, SSTR3, CHGA, GH1
18111in-pentetreotide449.3SST, CHGA, CALCA
19omeprazole44 28 49 11 2413.2GAST, CHGA, SST, SCT
20glucose449.1SCT, GAST, NTS, GHRH, SMAD4
21guanine44 11 2411.0CHGA, NTS, GH1, VIP, CALCA, SCT
22oxyntomodulin44 5910.0SST, NTS, VIP, GAST, CHGA, SCT
23dopamine44 28 11 2412.0GAST, GHRH, CHGA, NTS, SCT, VIP
24carbachol44 28 1111.0SCT, GAST, SST, VIP, NTS, CHGA
25ibmx44 28 5910.9GH1, VIP, CALCA, SST, SCT
26clonidine44 28 1110.9NTS, CALCA, SCT, GHRH, GH1, SST
27c-peptide448.9SCT, NTS, GH1, CHGA, SST, GAST
28gaba448.9NTS, CHGA, GAST, VIP, SST, SCT
29norepinephrine44 11 2410.9NTS, CHGA, GHRH, GAST, CALCA, VIP
30corticosterone44 59 2410.9GAST, GH1, CALCA, NTS, VIP
31atropine44 28 1110.8CALCA, SCT, GAST, GHRH, GH1, NTS
325-hydroxytryptamine448.8CALCA, CHGA, NTS, GAST, VIP, SST
33nifedipine44 49 28 1111.7GH1, GHRH, GAST, NTS, VIP, CHGA
34gnrh448.6NTS, CHGA, GH1, GHRH, GAST, VIP
35lactate448.5CHGA, SMAD4, GH1, CALCA, SST, VIP
36acth448.5GHRH, GH1, NTS, SST, CHGA, GAST
37serine448.3VIP, MEN1, SCT, GH1, NTS, MSH2
38propranolol44 28 49 11 2412.3GAST, CALCA, GHRH, GH1, CHGA, SST
39thyroxine44 249.3SST, GH1, GHRH, NTS, GAST, SCT
40vitamin d448.3CHGA, CALCA, MEN1, GAST, GH1, GHRH
41thymidine44 249.3VIP, SCT, SMAD4, NTS, GH1, GAST
42isoproterenol44 119.3GAST, SST, SCT, NTS, CHGA, GH1
43acetylcholine44 49 28 11 2412.3VIP, GAST, GH1, CHGA, NTS, CALCA
44histamine44 28 2410.1GAST, CXCR4, SST, NTS, CHGA, VIP
45epinephrine44 11 249.8CXCR4, SST, NTS, CHGA, GH1, GAST
46arginine447.8NTS, SST, CXCR4, MSH2, GHRH, SCT
47vegf447.6MEN1, GAST, VIP, CALCA, SMAD4, GH1
48adenylate447.6CHGA, NTS, CALCA, GHRH, VIP, SST
49octreotide44 59 28 1110.6SCT, GAST, GHRH, CHGA, CALCA, VIP
50testosterone44 59 11 2410.3VIP, CALCA, SCT, GAST, GHRH, SMAD4

GO Terms for genes affiliated with Vipoma

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16Gene Ontology
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Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.8SST, CALCA, SCT, PPY, GAST, GHRH

Biological processes related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:0086289.8SSTR3, SST
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6GH1, GHRH
3cell-cell signalingGO:0072679.1SSTR3, SST, GHRH, CALCA
4negative regulation of cell proliferationGO:0082859.0SMAD4, SSTR3, SST, MEN1
5G-protein coupled receptor signaling pathwayGO:0071868.8VIP, GAST, SST, CXCR4

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1R-SMAD bindingGO:0704129.8SMAD4, MEN1
2four-way junction DNA bindingGO:0004009.5MSH2, MEN1
3Y-form DNA bindingGO:0004039.3MSH2, MEN1
4hormone activityGO:0051797.6SST, VIP, CALCA, SCT, PPY, GAST

Products for genes affiliated with Vipoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet