MCID: VPM001
MIFTS: 59

Vipoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Vipoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards: Vipoma, also known as pancreatic cholera, is related to pancreatic cholera and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are ADP signalling through P2Y purinoceptor 12 and G alpha (s) signalling events. The compounds mibg and helospectin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and lung, and related mouse phenotypes are cardiovascular system and reproductive system.

Wikipedia:66 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 37MESH via Orphanet, 64UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

vipoma 9 44 11 46 50
pancreatic cholera 50 63
pancreatic vipoma 44 63
malignant vasoactive intestinal peptide-secreting tumor 9
vasoactive intestinal peptide-producing tumor 44
vasoactive intestinal peptide-secreting tumor 9
watery diarrhea - hypokalemia - achlorhydria 50
watery diarrhea - hypokalemic alkalosis 50
vasoactive intestinal peptide tumor 44
diarrheogenic islet cell tumor 50
verner-morrison syndrome 50
vip- secreting tumor 9
vip-secreting tumor 50
vipoma, malignant 9
malignant vipoma 63
wdha syndrome 50


External Ids:

Disease Ontology9 DOID:5574
MeSH36 D003969
NCIt41 C26749
ICD10 via Orphanet27 E16.8
SNOMED-CT59 253005002
SNOMED-CT via Orphanet60 447643008, 253005002, 70091000 39998009, more
MESH via Orphanet37 D003969
UMLS via Orphanet64 C0011993

Related Diseases for Vipoma

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18GeneCards, 19GeneDecks
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Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera31.4SST, VIP
2cholera31.1CALCA, NTS, CXCR4, VIP, SCT
3pancreatitis31.0SCT, SST, SMAD4
4diarrhea30.4CHGA, VIP, GAST, CALCA, SST
5pheochromocytoma30.3SCT, VIP, CHGA, MSH2, MEN1, SST
6wdha syndrome30.3CALCA, SST, VIP
7neurofibromatosis30.2MEN1, MSH2, SST
8glucagonoma30.0SCT, GAST, GHRH, GH1, MEN1, SST
9ulcerative colitis30.0NTS, VIP, MSH2
10parathyroid adenoma30.0MEN1, CHGA, CALCA
11neuroendocrine tumor29.9CALCA, CHGA, SST, VIP, GHRH
12multiple endocrine neoplasia29.9VIP, GAST, CHGA, MEN1, CALCA
13paraganglioma29.9GAST, CHGA, SST, MEN1, CALCA
14hypercalcemia29.9GAST, CALCA, MEN1, SCT, CHGA
15carcinoid syndrome29.6GAST, CALCA, GH1, GHRH, NTS, MEN1
16adenoma29.4GAST, CALCA, SMAD4, SCT, CHGA, GH1
17pancreatic vasoactive intestinal peptide producing tumor10.6
18small intestinal vasoactive intestinal peptide producing tumor10.5
19large cell carcinoma10.4
20hepatitis10.3
21somatostatin analog10.2
22angiodysplasia10.1SST
23intestinal disease10.1SST
24pituitary hypoplasia10.1GHRH
25pernicious anemia10.1GAST
26acth-secreting pituitary adenoma10.1GH1
27hypoadrenalism10.1GH1
28cowden disease10.1SMAD4
29dumping syndrome10.1NTS, SST
30secretory diarrhea10.1
31steatorrhea10.1SST, SCT
32neuroblastoma10.1VIP, NTS
33islet cell tumor10.1SST, GAST
34gigantism10.1SST, GH1
35pancreatic endocrine tumors10.1
36duodenogastric reflux10.1GAST, NTS
37acromegaly10.1SST, GH1
38duodenal ulcer10.1GAST, SCT
39achalasia10.1GAST, VIP
40merkel cell carcinoma10.1CHGA, SST
41hyperinsulinemic hypoglycemia10.1GAST, SST
42cushing's syndrome10.1SST, GH1
43growth retardation-mild developmental delay-chronic hepatitis syndrome10.1GHRH, GH1
44acinar cell carcinoma10.1CHGA, GAST
45pancreatic ductal carcinoma10.1SMAD4, CHGA
46ganglioneuroma10.1CHGA, VIP
47gastritis10.1SCT, GAST
48gastrointestinal system disease10.1SCT, GAST
49esophagitis10.1GAST, NTS
50growth hormone deficiency10.1GHRH, GH1

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Symptoms for Vipoma

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Drugs & Therapeutics for Vipoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Vipoma

Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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34MalaCards
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MalaCards organs/tissues related to Vipoma:

34
Pancreas, Liver, Lung, Colon

Animal Models for Vipoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Vipoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CXCR4, CALCA, CHGA, VIP, SMAD4, MEN1
2MP:00053898.1GH1, MEN1, SMAD4, GHRH, VIP, CHGA
3MP:00053797.9SMAD4, VIP, CHGA, GHRH, GH1, GAST
4MP:00020067.7GAST, CALCA, MEN1, MSH2, SMAD4
5MP:00053787.7GH1, SMAD4, CHGA, CXCR4, SST, MEN1
6MP:00053817.6SMAD4, CXCR4, MSH2, SST, MEN1, GAST
7MP:00053877.1GAST, GHRH, MEN1, SST, CXCR4, VIP
8MP:00036316.8CALCA, SMAD4, SCT, CXCR4, MSH2, MEN1
9MP:00107686.4MSH2, CHGA, VIP, SMAD4, MEN1, CALCA
10MP:00053765.5SMAD4, VIP, CHGA, GAST, CALCA, GH1

Publications for Vipoma

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Sources:
53PubMed
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Articles related to Vipoma:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
VIPoma in a 37-year-old man. (23993192)
2013
2
A rare cause of diarrhea: pancreatic VIPoma. (24008482)
2013
3
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
4
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
5
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
6
Benign pancreatic vipoma. (21526882)
2011
7
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
8
VIPoma syndrome: challenges in management. (20730389)
2010
9
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
10
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
11
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
12
Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]. (17292846)
2007
13
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
14
Radiofrequency ablation has a valuable therapeutic role in metastatic VIPoma. (16354964)
2006
15
Calcitonin-secreting VIPoma. (16416161)
2005
16
VIPomas: an update in diagnosis and management in a series of 11 patients. (16001675)
2005
17
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
18
Jejunal vipoma]. (15646540)
2004
19
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
20
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
21
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
22
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
23
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
24
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
25
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
26
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
27
Ondansetron and VIPoma. (8392671)
1993
28
Primary hepatic vipoma. (8389095)
1993
29
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
30
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
31
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
32
The somatostatin analog SMS 201-995 in long-term treatment of vipoma]. (2177234)
1990
33
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
34
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
35
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
36
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
37
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
38
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
39
VIPoma syndrome. (2820063)
1987
40
VIPoma syndrome. (3035922)
1987
41
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
42
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
43
Chronic diarrhea due to VIPoma in two children. (6319655)
1984
44
Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene. (6139527)
1983
45
Resolution of recurrent Verner-Morrison syndrome by resection of metastatic vipoma. (6297109)
1983
46
Vipoma. (6294887)
1982
47
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
48
A renal vipoma. (7437784)
1980
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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51PathCards, 56Reactome, 61Thomson Reuters, 54QIAGEN, 52PharmGKB, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Vipoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SCT, CALCA, GHRH
29.2CALCA, GHRH, VIP, SCT
3
Show member pathways
7.5NTS, SSTR3, SST, CXCR4, GHRH, GH1
4
Show member pathways
5.7GAST, SMAD4, SCT, VIP, CXCR4, SST

Compounds for genes affiliated with Vipoma

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1mibg469.5VIP, CALCA, SST, CHGA
2helospectin469.5VIP, SCT, CALCA
3naloxone46 30 52 1212.4NTS, GH1, GHRH, SST, VIP
4secretoneurin469.3SCT, CHGA, VIP
5sumatriptan46 30 62 52 25 1214.3GHRH, VIP, GH1, CALCA
6loxiglumide469.2SCT, NTS, GAST, SST
7levodopa46 1210.2SST, NTS, GHRH, GH1, CHGA
8lanreotide46 3010.1CHGA, SST, SSTR3, GHRH, GH1
95-hydroxyindoleacetic acid46 2510.1GAST, SST, CHGA, VIP
10minigastrin469.1VIP, SST, GAST
11lafutidine469.0CALCA, SST, SCT, GAST
12pirenzepine46 30 1211.0GAST, SST, GHRH, GH1
13ibmx46 62 3010.9CALCA, SST, VIP, GH1, SCT
14guanine46 25 1210.8CALCA, VIP, SCT, NTS, CHGA, GH1
15omeprazole46 52 30 25 1212.8SCT, CHGA, SST, GAST
16oxyntomodulin46 629.7GAST, NTS, SST, SCT, VIP, CHGA
17clonidine46 52 30 1211.7CALCA, GH1, GHRH, NTS, SST, CHGA
18carbachol46 30 1210.6CHGA, NTS, SST, VIP, SCT, GAST
19forskolin46 52 1210.6GH1, CALCA, VIP, GHRH, CHGA, SCT
20gaba468.5GAST, NTS, SST, SCT, VIP, CHGA
21c-peptide468.5CHGA, GH1, GAST, NTS, SST, SCT
22corticosterone46 62 2510.5VIP, NTS, GH1, CALCA, GAST
235-hydroxytryptamine468.4VIP, CALCA, GAST, SST, CHGA, NTS
24nifedipine46 30 52 1211.3GAST, GH1, GHRH, NTS, SST, VIP
25lactate468.3SST, CALCA, CHGA, GH1, VIP, SMAD4
26acth468.1GHRH, GAST, GH1, NTS, SST, CHGA
27thymidine46 259.0MEN1, SMAD4, GAST, GH1, NTS, VIP
28vitamin d468.0GH1, CHGA, GAST, MEN1, GHRH, CALCA
29gnrh468.0SST, GHRH, VIP, NTS, GAST, GH1
30pge2467.9CALCA, SST, NTS, VIP, GAST, SCT
31atropine46 30 129.9GAST, CALCA, GHRH, NTS, SST, VIP
32thyroxine46 258.9CALCA, VIP, SST, NTS, SCT, GH1
33propranolol46 30 52 25 1211.9SST, GHRH, GH1, CALCA, GAST, VIP
34isoproterenol46 128.8SCT, CHGA, SST, GH1, CALCA, GAST
35acetylcholine46 52 30 25 1211.8GAST, SCT, VIP, CHGA, SST, CALCA
36dexamethasone46 52 30 1210.7CXCR4, GH1, GAST, GHRH, NTS, SST
37histamine46 30 259.7VIP, GAST, CALCA, NTS, SCT, SST
38norepinephrine46 25 129.6GHRH, GH1, CALCA, GAST, CHGA, NTS
39dopamine46 30 25 1210.6CHGA, GAST, CALCA, GH1, NTS, GHRH
40arginine467.4MSH2, SMAD4, SCT, VIP, CHGA, NTS
41glucose467.3GH1, NTS, GAST, CHGA, SST, CXCR4
42epinephrine46 25 129.3SCT, VIP, CHGA, SST, GAST, CALCA
43vegf467.1CHGA, MEN1, GH1, CALCA, SMAD4, VIP
44estrogen467.1GH1, SMAD4, GHRH, CALCA, GAST, MEN1
45octreotide46 62 30 1210.1SCT, GAST, CALCA, VIP, CHGA, SST
46adenylate467.1GAST, CALCA, GH1, GHRH, NTS, SST
47tyrosine467.0GAST, GH1, NTS, MEN1, SMAD4, CXCR4
48glutamate466.8CXCR4, GAST, CALCA, GHRH, NTS, SST
49testosterone46 62 25 129.7SMAD4, SCT, VIP, CHGA, CXCR4, SST
50serine466.4SMAD4, MEN1, SCT, VIP, CHGA, CXCR4

GO Terms for genes affiliated with Vipoma

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17Gene Ontology
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Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5CALCA, SST, VIP
2terminal boutonGO:0431959.5CALCA, GHRH
3extracellular regionGO:0055767.1GAST, SCT, VIP, CHGA, SST, NTS

Biological processes related to Vipoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GHRH, GH1
2hormone-mediated apoptotic signaling pathwayGO:0086289.9SST, SSTR3
3positive regulation of vasodilationGO:0459099.8CALCA, VIP
4positive regulation of multicellular organism growthGO:0400189.8GH1, GHRH
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.8MEN1, SMAD4
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, GHRH
7positive regulation of cAMP biosynthetic processGO:0308199.5GHRH, CALCA
8germ cell developmentGO:0072819.2MSH2, CXCR4
9cell-cell signalingGO:0072679.2CALCA, SST, SSTR3, GHRH
10negative regulation of cell proliferationGO:0082859.1SMAD4, SST, SSTR3, MEN1
11G-protein coupled receptor signaling pathwayGO:0071868.8GAST, VIP, CXCR4, SST

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.9VIP, NTS
2Y-form DNA bindingGO:0004039.5MSH2, MEN1
3R-SMAD bindingGO:0704129.4MEN1, SMAD4
4four-way junction DNA bindingGO:0004009.3MEN1, MSH2
5hormone activityGO:0051798.2SCT, VIP, SST, GH1, CALCA, GAST
6protein bindingGO:0055155.9MEN1, NTS, GH1, CALCA, MSH2, CXCR4

Products for genes affiliated with Vipoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vipoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet