MCID: VPM001
MIFTS: 50

Vipoma malady

Gastrointestinal, Endocrine, Cancer categories

Summaries for Vipoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards: Vipoma, also known as pancreatic cholera, is related to pancreatic cholera and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Class A/1 (Rhodopsin-like receptors). The compounds pge2 and forskolin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are nervous system and endocrine/exocrine gland.

Wikipedia:64 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 26ICD10 via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

vipoma 8 43 10 45 49
pancreatic cholera 49 61
pancreatic vipoma 43 61
malignant vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-secreting tumor 8
vasoactive intestinal peptide-producing tumor 43
watery diarrhea - hypokalemia - achlorhydria 49
watery diarrhea - hypokalemic alkalosis 49
vasoactive intestinal peptide tumor 43
diarrheogenic islet cell tumor 49
verner-morrison syndrome 49
vip- secreting tumor 8
vip-secreting tumor 49
vipoma, malignant 8
malignant vipoma 61
wdha syndrome 49


External Ids:

Disease Ontology8 DOID:5574
NCIt40 C26749
MeSH35 D003969
SNOMED-CT57 253005002
ICD10 via Orphanet26 E16.8
MESH via Orphanet36 D003969

Related Diseases for Vipoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera31.2VIP, PPY, SST
2cholera31.2CXCR4, NTS, SCT, CALCA, VIP
3pheochromocytoma30.4VIP, CALCA, SCT, MEN1, CHGA, NTS
4wdha syndrome30.2SST, CALCA, VIP
5multiple endocrine neoplasia30.1VIP, CHGA, MEN1, GAST, CALCA
6glucagonoma30.1SST, CHGA, GH1, GHRH, MEN1, GAST
7neurofibromatosis30.1MSH2, SST, MEN1
8paraganglioma29.9CALCA, GAST, MEN1, CHGA, SST
9hypercalcemia29.9CALCA, SCT, GAST, MEN1, CHGA
10carcinoid syndrome29.8GHRH, MEN1, GAST, SCT, CALCA, VIP
11adenocarcinoma29.8VIP, SCT, GAST, MEN1, CHGA, NTS
12adenoma29.8SMAD4, MSH2, CXCR4, SSTR3, SST, NTS
13pancreatic vasoactive intestinal peptide producing tumor10.6
14small intestinal vasoactive intestinal peptide producing tumor10.5
15somatostatin analog10.5
16large cell carcinoma10.3
17micro syndrome10.2
18secretory diarrhea10.1
19char syndrome10.1
20duodenum cancer10.0SST
21cholelithiasis10.0SST
22constipation10.0VIP
23hirschsprung's disease10.0VIP
24ganglioneuroblastoma10.0VIP
25duodenitis10.0GAST
26parkinson's disease10.0NTS
27dyspepsia10.0GAST
28gastroduodenitis10.0GAST
29fibrous dysplasia10.0GH1
30essential hypertension10.0NTS
31gastric ulcer10.0GAST
32angiodysplasia10.0SST
33prader-willi syndrome10.0GH1
34acth-secreting pituitary adenoma10.0GH1
35panic disorder10.0GHRH
36lung cancer10.0SST, CHGA
37galactosemia10.0SST
38von hippel-lindau disease10.0MEN1
39neuroblastoma10.0NTS, VIP
40dumping syndrome10.0NTS, SST
41hypoadrenalism10.0GH1
42pernicious anemia10.0GAST
43esophagitis10.0GAST, NTS
44deficiency anemia10.0GHRH, SMAD4
45sarcoma10.0MSH2
46hypothyroidism10.0GH1, GHRH
47parathyroid carcinoma10.0MEN1
48anorexia nervosa10.0GH1, GHRH
49carney complex10.0MEN1
50ganglioneuroma10.0VIP, CHGA

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Clinical Features for Vipoma

Drugs & Therapeutics for Vipoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Vipoma

Drug clinical trials:

Search ClinicalTrials for Vipoma

Search NIH Clinical Center for Vipoma

Search CenterWatch for Vipoma

Genetic Tests for Vipoma

Anatomical Context for Vipoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Vipoma:

33
Small intestine, Colon, Liver, Lung, Pancreas, Pancreatic islet

Animal Models for Vipoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Vipoma

Sources:
51PubMed
See all sources

Articles related to Vipoma:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
VIPoma in a 37-year-old man. (23993192)
2013
2
Sunitinib for the treatment of metastatic paraganglioma and vasoactive intestinal polypeptide-producing tumor (VIPoma). (23407483)
2013
3
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
4
VIPoma syndrome: challenges in management. (20730389)
2010
5
Amelioration of symptoms and reduction of VIP levels after hepatic artery chemoembolization in a patient with sandostatin resistant VIPoma. (20351979)
2010
6
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
7
VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome. (19184565)
2009
8
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
9
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
10
Jejunal vipoma]. (15646540)
2004
11
VIPoma. (15590967)
2004
12
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
13
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
14
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
15
VIPoma of pancreas in a child. (11059195)
2000
16
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
17
Pathophysiology and management of VIPoma: a case study. (8829164)
1996
18
Massive amyloid deposition in pancreatic vipoma: a case report. (9007963)
1996
19
Metastasizing pancreatic vipoma. Its diagnosis and therapy with the somatostatin analog octreotide]. (7588006)
1995
20
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
21
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
22
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
23
Stimulation of vasoactive intestinal peptide and neurotensin secretion by pentagastrin in a patient with VIPoma syndrome. (8128360)
1994
24
Ondansetron and VIPoma. (8392671)
1993
25
Primary hepatic vipoma. (8389095)
1993
26
Calcitonin, as SMS 201-995, ameliorates the VIPoma syndrome. (8383153)
1993
27
Long-term therapy of a metastasizing pancreatic vipoma using the somatostatin derivative octreotide]. (1326786)
1992
28
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
29
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
30
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
31
The somatostatin analog SMS 201-995 in long-term treatment of vipoma]. (2177234)
1990
32
Treatment of metastatic Vipoma by liver transplantation. (10150088)
1990
33
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
34
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
35
Vipoma syndrome simultaneously occurring with small-cell carcinoma of the lung. (2541667)
1989
36
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
37
Successful treatment of a VIPoma by continuous subcutaneous infusion of somatostatin analogue (SMS 201-995). (2856504)
1988
38
VIPoma syndrome. (3035922)
1987
39
Escape of the response to a long-acting somatostatin analogue (SMS 201-995) in patients with VIPoma. (2878857)
1987
40
Resection of a vipoma of the pancreas in a 15-year-old girl. (3025400)
1986
41
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
42
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
43
Long-term treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases. (2856877)
1985
44
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
45
Vipoma and watery diarrhea. (6283355)
1982
46
Loperamide therapy in a child with vipoma-associated diarrhoea. (6123702)
1982
47
Clinicopathological study of pancreatic and ganglioneuroblastoma tumours secreting vasoactive intestinal polypeptide (vipomas). (6786616)
1981
48
Presacral vipoma in a 16-month-old child. (6278821)
1981
49
Localisation of vipoma. (427420)
1979
50
Vipoma of the pancreas: observations on the diarhrhea and circulatory disturbances. (435002)
1979

Genetic Variations for Vipoma

Expression for genes affiliated with Vipoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Vipoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1pge24510.5SST
2forskolin45 50 1111.9GHRH, SCT, CALCA
3secretoneurin459.8VIP, SCT, CHGA
4bromocriptine29 45 1111.8SST, GHRH, VIP
5dexamethasone45 50 29 1112.7VIP, GHRH, GH1, NTS
6mibg459.7VIP, CALCA, CHGA, SST
7helospectin459.6VIP, CALCA, SCT
8minigastrin459.6VIP, GAST, SST
9naloxone45 50 29 1112.6VIP, GHRH, GH1, NTS, SST
10sumatriptan45 29 60 50 11 2414.5GH1, GHRH, CALCA, VIP
11glutamate459.5SCT, GAST, GHRH, NTS
12loxiglumide459.5SCT, GAST, NTS, SST
135-hydroxyindoleacetic acid45 2410.4SST, CHGA, GAST, VIP
14pirenzepine45 29 1111.4SST, GH1, GHRH, GAST
15levodopa45 1110.4GHRH, GH1, CHGA, NTS, SST
16lafutidine459.3CALCA, SCT, GAST, SST
17lanreotide45 2910.3GHRH, GH1, CHGA, SST, SSTR3
18111in-pentetreotide459.3SST, CHGA, CALCA
19omeprazole45 29 50 11 2413.2SST, CHGA, GAST, SCT
20glucose459.1SCT, GAST, GHRH, NTS, SMAD4
21guanine45 11 2411.0VIP, CALCA, SCT, GH1, CHGA, NTS
22oxyntomodulin45 6010.0SST, NTS, CHGA, GAST, SCT, VIP
23dopamine45 29 11 2412.0VIP, SCT, GAST, GHRH, CHGA, NTS
24carbachol45 29 1111.0VIP, SCT, GAST, CHGA, NTS, SST
25ibmx45 29 6010.9VIP, CALCA, SCT, GH1, SST
26clonidine45 29 1110.9CALCA, SCT, GHRH, GH1, CHGA, NTS
27c-peptide458.9SCT, GAST, GH1, CHGA, NTS, SST
28gaba458.9VIP, SCT, GAST, CHGA, NTS, SST
29norepinephrine45 11 2410.9VIP, CALCA, GAST, GHRH, CHGA, NTS
30corticosterone45 60 2410.9VIP, CALCA, GAST, GH1, NTS
31atropine45 29 1110.8SCT, CALCA, GAST, GHRH, GH1, NTS
325-hydroxytryptamine458.8VIP, CALCA, GAST, CHGA, NTS, SST
33nifedipine45 50 29 1111.7VIP, GAST, GHRH, GH1, CHGA, NTS
34gnrh458.6VIP, GAST, GHRH, GH1, CHGA, NTS
35lactate458.5VIP, CALCA, GH1, CHGA, SST, CXCR4
36acth458.5VIP, SCT, GAST, GHRH, GH1, CHGA
37serine458.3VIP, SCT, MEN1, GHRH, GH1, NTS
38thyroxine45 249.3VIP, CALCA, SCT, GAST, GHRH, GH1
39propranolol45 29 50 11 2412.3SST, CHGA, GH1, GHRH, GAST, SCT
40vitamin d458.3CALCA, GAST, MEN1, GHRH, GH1, CHGA
41thymidine45 249.3VIP, SCT, GAST, MEN1, GH1, NTS
42isoproterenol45 119.3VIP, CALCA, SCT, GAST, GH1, CHGA
43acetylcholine45 50 29 11 2412.3VIP, CALCA, SCT, GAST, GH1, CHGA
44histamine45 29 2410.1VIP, CALCA, SCT, GAST, CHGA, NTS
45epinephrine45 11 249.8VIP, CALCA, SCT, CXCR4, SST, NTS
46arginine457.8VIP, SCT, GHRH, GH1, CHGA, NTS
47vegf457.6VIP, CALCA, GAST, MEN1, GH1, CHGA
48adenylate457.6VIP, CALCA, SCT, GAST, GHRH, GH1
49octreotide45 60 29 1110.6SSTR3, SST, NTS, CHGA, GH1, GHRH
50testosterone45 60 11 2410.3VIP, CALCA, SCT, GAST, GHRH, GH1

GO Terms for genes affiliated with Vipoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.8SST, CALCA, SCT, PPY, GAST, GHRH

Biological processes related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:0086289.8SSTR3, SST
2positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.6GH1, GHRH
3cell-cell signalingGO:0072679.1SSTR3, SST, GHRH, CALCA
4negative regulation of cell proliferationGO:0082859.0SMAD4, SSTR3, SST, MEN1
5G-protein coupled receptor signaling pathwayGO:0071868.8VIP, GAST, SST, CXCR4

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1R-SMAD bindingGO:0704129.8SMAD4, MEN1
2four-way junction DNA bindingGO:0004009.5MSH2, MEN1
3Y-form DNA bindingGO:0004039.3MSH2, MEN1
4hormone activityGO:0051797.6SST, VIP, CALCA, SCT, PPY, GAST

Products for genes affiliated with Vipoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Vipoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet