MCID: VPM001
MIFTS: 51

Vipoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Vipoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 39NCIt, 56SNOMED-CT, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Vipoma:

Name: Vipoma 8 42 10 44 48 61
Pancreatic Cholera 42 48 61
Wdha Syndrome 42 44 48
Watery Diarrhea - Hypokalemia - Achlorhydria 42 48
Watery Diarrhea - Hypokalemic Alkalosis 42 48
Diarrheogenic Islet Cell Tumor 42 48
Verner-Morrison Syndrome 42 48
Vip-Secreting Tumor 42 48
Pancreatic Vipoma 42 61
 
Malignant Vasoactive Intestinal Peptide-Secreting Tumor 8
Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome 42
Vasoactive Intestinal Peptide-Producing Tumor 42
Vasoactive Intestinal Peptide-Secreting Tumor 8
Vasoactive Intestinal Peptide Tumor 42
Vip- Secreting Tumor 8
Vipoma, Malignant 8
Malignant Vipoma 61


Classifications:



Characteristics (Orphanet epidemiological data):

48
vipoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology8 DOID:5574
NCIt39 C26749
MeSH33 D003969
Orphanet48 97282
SNOMED-CT56 253005002
MESH via Orphanet34 D003969
ICD10 via Orphanet26 E16.8
UMLS via Orphanet62 C0011993

Summaries for Vipoma

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NIH Rare Diseases:42 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards based summary: Vipoma, also known as pancreatic cholera, is related to pancreatitis and cholera. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are ADP signalling through P2Y purinoceptor 12 and G alpha (s) signalling events. The compounds mibg and helospectin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are cardiovascular system and reproductive system.

Wikipedia:64 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Related Diseases for Vipoma

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Diseases related to Vipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.3SCT, SST, SMAD4
2cholera30.8CALCA, NTS, CXCR4, VIP, SCT
3pancreatic cholera30.7SST, VIP
4diarrhea30.3CHGA, VIP, GAST, CALCA, SST
5neurofibromatosis30.3MEN1, MSH2, SST
6ulcerative colitis30.1NTS, VIP, MSH2
7parathyroid adenoma30.0MEN1, CHGA, CALCA
8multiple endocrine neoplasia29.7VIP, GAST, CHGA, MEN1, CALCA
9neuroendocrine tumor29.6SST, CALCA, GAST, CHGA, MEN1
10paraganglioma29.6GAST, CHGA, SST, MEN1, CALCA
11hypercalcemia29.6GAST, CALCA, MEN1, SCT, CHGA
12pheochromocytoma29.6SCT, VIP, CHGA, MSH2, MEN1, SST
13glucagonoma29.5SCT, GAST, GHRH, GH1, MEN1, SST
14carcinoid syndrome28.4GAST, CALCA, GH1, GHRH, NTS, MEN1
15adenoma27.4GAST, CALCA, SMAD4, SCT, CHGA, GH1
16small intestinal vasoactive intestinal peptide producing tumor10.6
17angiodysplasia10.5SST
18intestinal disease10.5SST
19pituitary hypoplasia10.5GHRH
20pernicious anemia10.5GAST
21pituitary-dependent cushing's disease10.5GH1
22hypoadrenalism10.5GH1
23cowden disease10.5SMAD4
24dumping syndrome10.4NTS, SST
25steatorrhea10.4SST, SCT
26neuroblastoma10.4VIP, NTS
27large cell carcinoma10.4
28islet cell tumor10.4SST, GAST
29gigantism10.4SST, GH1
30duodenogastric reflux10.4GAST, NTS
31pituitary gigantism10.4SST, GH1
32duodenal ulcer10.4GAST, SCT
33merkel cell carcinoma10.4CHGA, SST
34achalasia10.4GAST, VIP
35hyperinsulinemic hypoglycemia10.4GAST, SST
36cushing's syndrome10.4SST, GH1
37pancreatic ductal carcinoma10.4SMAD4, CHGA
38acinar cell carcinoma10.4CHGA, GAST
39ganglioneuroma10.3CHGA, VIP
40gastritis10.3SCT, GAST
41gastrointestinal system disease10.3SCT, GAST
42esophagitis10.3GAST, NTS
43growth hormone deficiency10.3GHRH, GH1
44apudoma10.3SST, CALCA
45hepatitis10.3
46cluster headache10.3VIP, CALCA
47peptic ulcer disease10.3GAST, SST, SCT
48adrenocortical carcinoma10.3SMAD4, CHGA, VIP
49adrenal gland hyperfunction10.3GH1, SST, GHRH
50hypopituitarism10.3SST, GHRH, GH1

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Symptoms for Vipoma

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Drugs & Therapeutics for Vipoma

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Drug clinical trials:

Search ClinicalTrials for Vipoma

Search NIH Clinical Center for Vipoma

Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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MalaCards organs/tissues related to Vipoma:

31
Pancreas, Liver, Colon, Lung

Animal Models for Vipoma or affiliated genes

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MGI Mouse Phenotypes related to Vipoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CXCR4, CALCA, CHGA, VIP, SMAD4, MEN1
2MP:00053898.1GH1, MEN1, SMAD4, GHRH, VIP, CHGA
3MP:00053797.9SMAD4, VIP, CHGA, GHRH, GH1, GAST
4MP:00020067.7GAST, CALCA, MEN1, MSH2, SMAD4
5MP:00053787.7GH1, SMAD4, CHGA, CXCR4, SST, MEN1
6MP:00053817.6SMAD4, CXCR4, MSH2, SST, MEN1, GAST
7MP:00053877.1GAST, GHRH, MEN1, SST, CXCR4, VIP
8MP:00036316.8CALCA, SMAD4, SCT, CXCR4, MSH2, MEN1
9MP:00107686.4MSH2, CHGA, VIP, SMAD4, MEN1, CALCA
10MP:00053765.5SMAD4, VIP, CHGA, GAST, CALCA, GH1

Publications for Vipoma

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Articles related to Vipoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Extra-pancreatic vipoma. (25184777)
2014
2
Sunitinib Achieved Fast and Sustained Control of VIPoma Symptoms. (25305306)
2014
3
Sporadic pancreatic vasoactive intestinal peptide-producing tumor (VIPoma) in a 47-year-old male. (24785507)
2014
4
Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma. (25349667)
2014
5
VIPoma in a 37-year-old man. (23993192)
2013
6
A rare cause of diarrhea: pancreatic VIPoma. (24008482)
2013
7
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
8
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
9
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
10
Benign pancreatic vipoma. (21526882)
2011
11
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
12
VIPoma syndrome: challenges in management. (20730389)
2010
13
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
14
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
15
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
16
Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]. (17292846)
2007
17
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
18
Calcitonin-secreting VIPoma. (16416161)
2005
19
VIPomas: an update in diagnosis and management in a series of 11 patients. (16001675)
2005
20
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
21
Jejunal vipoma]. (15646540)
2004
22
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
23
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
24
Vasoactive Intestinal Peptide Tumor (VIPoma) (25905195)
2000
25
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
26
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
27
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
28
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
29
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
30
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
31
Ondansetron and VIPoma. (8392671)
1993
32
Primary hepatic vipoma. (8389095)
1993
33
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
34
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
35
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
36
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
37
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
38
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
39
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
40
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
41
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
42
VIPoma syndrome. (2820063)
1987
43
VIPoma syndrome. (3035922)
1987
44
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
45
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
46
Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene. (6139527)
1983
47
Vipoma. (6294887)
1982
48
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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Pathways related to Vipoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CALCA, GHRH, SCT
29.2SCT, VIP, GHRH, CALCA
3
Show member pathways
7.5SCT, CXCR4, SST, SSTR3, NTS, GHRH
4
Show member pathways
5.7GAST, SMAD4, SCT, VIP, CXCR4, SST

Compounds for genes affiliated with Vipoma

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Compounds related to Vipoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1mibg449.5VIP, CALCA, SST, CHGA
2helospectin449.5VIP, SCT, CALCA
3naloxone44 28 50 1112.4NTS, GH1, GHRH, SST, VIP
4secretoneurin449.3SCT, CHGA, VIP
5sumatriptan44 28 60 50 24 1114.3GHRH, VIP, GH1, CALCA
6loxiglumide449.2SCT, NTS, GAST, SST
7levodopa44 1110.2SST, NTS, GHRH, GH1, CHGA
8lanreotide44 2810.1CHGA, SST, SSTR3, GHRH, GH1
95-hydroxyindoleacetic acid44 2410.1GAST, SST, CHGA, VIP
10minigastrin449.1VIP, SST, GAST
11lafutidine449.0CALCA, SST, SCT, GAST
12pirenzepine44 28 1111.0GAST, SST, GHRH, GH1
13ibmx44 60 2810.9CALCA, SST, VIP, GH1, SCT
14guanine44 24 1110.8CALCA, VIP, SCT, NTS, CHGA, GH1
15omeprazole44 50 28 24 1112.8SCT, CHGA, SST, GAST
16oxyntomodulin44 609.7GAST, NTS, SST, SCT, VIP, CHGA
17clonidine44 50 28 1111.7CALCA, GH1, GHRH, NTS, SST, CHGA
18carbachol44 28 1110.6CHGA, NTS, SST, VIP, SCT, GAST
19forskolin44 50 1110.6GH1, CALCA, VIP, GHRH, CHGA, SCT
20gaba448.5GAST, NTS, SST, SCT, VIP, CHGA
21c-peptide448.5CHGA, GH1, GAST, NTS, SST, SCT
22corticosterone44 60 2410.5VIP, NTS, GH1, CALCA, GAST
235-hydroxytryptamine448.4VIP, CALCA, GAST, SST, CHGA, NTS
24nifedipine44 28 50 1111.3GAST, GH1, GHRH, NTS, SST, VIP
25lactate448.3SST, CALCA, CHGA, GH1, VIP, SMAD4
26acth448.1GHRH, GAST, GH1, NTS, SST, CHGA
27thymidine44 249.0MEN1, SMAD4, GAST, GH1, NTS, VIP
28vitamin d448.0GH1, CHGA, GAST, MEN1, GHRH, CALCA
29gnrh448.0SST, GHRH, VIP, NTS, GAST, GH1
30pge2447.9CALCA, SST, NTS, VIP, GAST, SCT
31atropine44 28 119.9GAST, CALCA, GHRH, NTS, SST, VIP
32thyroxine44 248.9CALCA, VIP, SST, NTS, SCT, GH1
33propranolol44 28 50 24 1111.9SST, GHRH, GH1, CALCA, GAST, VIP
34isoproterenol44 118.8SCT, CHGA, SST, GH1, CALCA, GAST
35acetylcholine44 50 28 24 1111.8GAST, SCT, VIP, CHGA, SST, CALCA
36dexamethasone44 50 28 1110.7CXCR4, GH1, GAST, GHRH, NTS, SST
37histamine44 28 249.7VIP, GAST, CALCA, NTS, SCT, SST
38norepinephrine44 24 119.6GHRH, GH1, CALCA, GAST, CHGA, NTS
39dopamine44 28 24 1110.6CHGA, GAST, CALCA, GH1, NTS, GHRH
40arginine447.4MSH2, SMAD4, SCT, VIP, CHGA, NTS
41glucose447.3GH1, NTS, GAST, CHGA, SST, CXCR4
42epinephrine44 24 119.3SCT, VIP, CHGA, SST, GAST, CALCA
43vegf447.1CHGA, MEN1, GH1, CALCA, SMAD4, VIP
44estrogen447.1GH1, SMAD4, GHRH, CALCA, GAST, MEN1
45octreotide44 60 28 1110.1SCT, GAST, CALCA, VIP, CHGA, SST
46adenylate447.1GAST, CALCA, GH1, GHRH, NTS, SST
47tyrosine447.0GAST, GH1, NTS, MEN1, SMAD4, CXCR4
48glutamate446.8CXCR4, GAST, CALCA, GHRH, NTS, SST
49testosterone44 60 24 119.7SMAD4, SCT, VIP, CHGA, CXCR4, SST
50serine446.4SMAD4, MEN1, SCT, VIP, CHGA, CXCR4

GO Terms for genes affiliated with Vipoma

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Cellular components related to Vipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.5CALCA, SST, VIP
2terminal boutonGO:00431959.5CALCA, GHRH
3extracellular regionGO:00055767.1GAST, SCT, VIP, CHGA, SST, NTS

Biological processes related to Vipoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.0GHRH, GH1
2hormone-mediated apoptotic signaling pathwayGO:00086289.9SSTR3, SST
3positive regulation of vasodilationGO:00459099.8CALCA, VIP
4positive regulation of multicellular organism growthGO:00400189.8GHRH, GH1
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:00305119.8MEN1, SMAD4
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.8CALCA, GHRH
7positive regulation of cAMP biosynthetic processGO:00308199.5CALCA, GHRH
8germ cell developmentGO:00072819.2MSH2, CXCR4
9cell-cell signalingGO:00072679.2CALCA, GHRH, SSTR3, SST
10negative regulation of cell proliferationGO:00082859.1MEN1, SSTR3, SST, SMAD4
11G-protein coupled receptor signaling pathwayGO:00071868.8VIP, CXCR4, SST, GAST

Molecular functions related to Vipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.9NTS, VIP
2Y-form DNA bindingGO:00004039.5MSH2, MEN1
3R-SMAD bindingGO:00704129.4MEN1, SMAD4
4four-way junction DNA bindingGO:00004009.3MSH2, MEN1
5hormone activityGO:00051798.2GAST, CALCA, GH1, SST, VIP, SCT
6protein bindingGO:00055155.9SMAD4, VIP, CXCR4, MSH2, SSTR3, MEN1

Sources for Vipoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet