MCID: VPM001
MIFTS: 58

Vipoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Vipoma

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NIH Rare Diseases:42 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards based summary: Vipoma, also known as vasoactive intestinal peptide-producing tumor, is related to pancreatic cholera and pancreatitis. An important gene associated with Vipoma is VIP (vasoactive intestinal peptide), and among its related pathways are ADP signalling through P2Y purinoceptor 12 and G alpha (s) signalling events. The compounds mibg and helospectin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and colon, and related mouse phenotypes are cardiovascular system and reproductive system.

Wikipedia:64 A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it) is a rare... more...

Aliases & Classifications for Vipoma

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Sources:
9Disease Ontology, 42NIH Rare Diseases, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Vipoma, Aliases & Descriptions:

Name: Vipoma 9 42 11 44 48
Vasoactive Intestinal Peptide-Producing Tumor 42 61
Vasoactive Intestinal Peptide-Secreting Tumor 9 61
Diarrheogenic Islet Cell Tumor 48 61
Verner-Morrison Syndrome 48 61
Vip- Secreting Tumor 9 61
Pancreatic Cholera 48 61
Pancreatic Vipoma 42 61
 
Wdha Syndrome 48 61
Malignant Vasoactive Intestinal Peptide-Secreting Tumor 9
Watery Diarrhea - Hypokalemia - Achlorhydria 48
Watery Diarrhea - Hypokalemic Alkalosis 48
Vasoactive Intestinal Peptide Tumor 42
Vip-Secreting Tumor 48
Vipoma, Malignant 9
Malignant Vipoma 61


Classifications:



External Ids:

Disease Ontology9 DOID:5574
NCIt39 C26749
MeSH34 D003969
SNOMED-CT56 253005002
MESH via Orphanet35 D003969
ICD10 via Orphanet27 E16.8
UMLS via Orphanet62 C0011993

Related Diseases for Vipoma

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Diseases related to Vipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cholera32.0SST, VIP
2pancreatitis31.3SCT, SST, SMAD4
3cholera30.8CALCA, NTS, CXCR4, VIP, SCT
4wdha syndrome30.6CALCA, SST, VIP
5diarrhea30.4CHGA, VIP, GAST, CALCA, SST
6neurofibromatosis30.3MEN1, MSH2, SST
7ulcerative colitis30.1NTS, VIP, MSH2
8parathyroid adenoma30.0MEN1, CHGA, CALCA
9neuroendocrine tumor29.9CALCA, CHGA, SST, VIP, GHRH
10multiple endocrine neoplasia29.7VIP, GAST, CHGA, MEN1, CALCA
11paraganglioma29.6GAST, CHGA, SST, MEN1, CALCA
12hypercalcemia29.6GAST, CALCA, MEN1, SCT, CHGA
13pheochromocytoma29.6SCT, VIP, CHGA, MSH2, MEN1, SST
14glucagonoma29.5SCT, GAST, GHRH, GH1, MEN1, SST
15carcinoid syndrome28.4GAST, CALCA, GH1, GHRH, NTS, MEN1
16adenoma27.4GAST, CALCA, SMAD4, SCT, CHGA, GH1
17small intestinal vasoactive intestinal peptide producing tumor10.6
18angiodysplasia10.5SST
19intestinal disease10.5SST
20pituitary hypoplasia10.5GHRH
21pernicious anemia10.5GAST
22acth-secreting pituitary adenoma10.5GH1
23hypoadrenalism10.5GH1
24cowden disease10.5SMAD4
25dumping syndrome10.4NTS, SST
26steatorrhea10.4SST, SCT
27neuroblastoma10.4VIP, NTS
28pancreatic islet cell tumors10.4SST, GAST
29gigantism10.4SST, GH1
30duodenogastric reflux10.4GAST, NTS
31large cell carcinoma10.4
32acromegaly10.4SST, GH1
33duodenal ulcer10.4GAST, SCT
34achalasia10.4GAST, VIP
35merkel cell carcinoma10.4CHGA, SST
36hyperinsulinemic hypoglycemia10.4GAST, SST
37cushing's syndrome10.4SST, GH1
38pancreatic ductal carcinoma10.4SMAD4, CHGA
39acinar cell carcinoma10.4CHGA, GAST
40ganglioneuroma10.3CHGA, VIP
41gastritis10.3SCT, GAST
42gastrointestinal system disease10.3SCT, GAST
43esophagitis10.3GAST, NTS
44growth hormone deficiency10.3GHRH, GH1
45apudoma10.3SST, CALCA
46cluster headache10.3VIP, CALCA
47hepatitis10.3
48peptic ulcer disease10.3GAST, SST, SCT
49adrenocortical carcinoma10.3SMAD4, CHGA, VIP
50adrenal gland hyperfunction10.3GH1, SST, GHRH

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Symptoms for Vipoma

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Drugs & Therapeutics for Vipoma

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Drug clinical trials:

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Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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MalaCards organs/tissues related to Vipoma:

32
Pancreas, Liver, Colon, Lung

Animal Models for Vipoma or affiliated genes

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MGI Mouse Phenotypes related to Vipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2VIP, CHGA, CXCR4, MEN1, CALCA, SMAD4
2MP:00053898.1SMAD4, VIP, CHGA, CXCR4, MEN1, GHRH
3MP:00053797.9SMAD4, VIP, CHGA, MEN1, GHRH, GH1
4MP:00020067.7SMAD4, MSH2, MEN1, CALCA, GAST
5MP:00053787.7SMAD4, CHGA, CXCR4, SST, MEN1, NTS
6MP:00053817.6SMAD4, CXCR4, MSH2, SST, MEN1, GAST
7MP:00053877.1SMAD4, VIP, CXCR4, MSH2, SST, MEN1
8MP:00036316.8SMAD4, SCT, CXCR4, MSH2, SST, MEN1
9MP:00107686.4SMAD4, VIP, CHGA, CXCR4, MSH2, MEN1
10MP:00053765.5GAST, SMAD4, SCT, VIP, CHGA, CXCR4

Publications for Vipoma

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Articles related to Vipoma:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Extra-pancreatic vipoma. (25184777)
2014
2
Sunitinib Achieved Fast and Sustained Control of VIPoma Symptoms. (25305306)
2014
3
Sporadic pancreatic vasoactive intestinal peptide-producing tumor (VIPoma) in a 47-year-old male. (24785507)
2014
4
Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma. (25349667)
2014
5
VIPoma in a 37-year-old man. (23993192)
2013
6
A rare cause of diarrhea: pancreatic VIPoma. (24008482)
2013
7
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
8
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
9
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
10
Benign pancreatic vipoma. (21526882)
2011
11
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
12
VIPoma syndrome: challenges in management. (20730389)
2010
13
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
14
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
15
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
16
Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]. (17292846)
2007
17
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
18
Calcitonin-secreting VIPoma. (16416161)
2005
19
VIPomas: an update in diagnosis and management in a series of 11 patients. (16001675)
2005
20
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
21
Jejunal vipoma]. (15646540)
2004
22
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
23
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
24
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
25
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
26
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
27
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
28
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
29
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
30
Ondansetron and VIPoma. (8392671)
1993
31
Primary hepatic vipoma. (8389095)
1993
32
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
33
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
34
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
35
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
36
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
37
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
38
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
39
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
40
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
41
VIPoma syndrome. (2820063)
1987
42
VIPoma syndrome. (3035922)
1987
43
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
44
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
45
Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene. (6139527)
1983
46
Resolution of recurrent Verner-Morrison syndrome by resection of metastatic vipoma. (6297109)
1983
47
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
48
A renal vipoma. (7437784)
1980
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Expression patterns in normal tissues for genes affiliated with Vipoma

Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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Pathways related to Vipoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CALCA, GHRH, SCT
29.2SCT, VIP, GHRH, CALCA
3
Show member pathways
7.5SCT, CXCR4, SST, SSTR3, NTS, GHRH
4
Show member pathways
5.7GAST, SMAD4, SCT, VIP, CXCR4, SST

Compounds for genes affiliated with Vipoma

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Compounds related to Vipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1mibg449.5VIP, CALCA, SST, CHGA
2helospectin449.5VIP, SCT, CALCA
3naloxone44 29 50 1212.4NTS, GH1, GHRH, SST, VIP
4secretoneurin449.3SCT, CHGA, VIP
5sumatriptan44 29 60 50 25 1214.3GHRH, VIP, GH1, CALCA
6loxiglumide449.2SCT, NTS, GAST, SST
7levodopa44 1210.2SST, NTS, GHRH, GH1, CHGA
8lanreotide44 2910.1CHGA, SST, SSTR3, GHRH, GH1
95-hydroxyindoleacetic acid44 2510.1GAST, SST, CHGA, VIP
10minigastrin449.1VIP, SST, GAST
11lafutidine449.0CALCA, SST, SCT, GAST
12pirenzepine44 29 1211.0GAST, SST, GHRH, GH1
13ibmx44 60 2910.9CALCA, SST, VIP, GH1, SCT
14guanine44 25 1210.8CALCA, VIP, SCT, NTS, CHGA, GH1
15omeprazole44 50 29 25 1212.8SCT, CHGA, SST, GAST
16oxyntomodulin44 609.7GAST, NTS, SST, SCT, VIP, CHGA
17clonidine44 50 29 1211.7CALCA, GH1, GHRH, NTS, SST, CHGA
18carbachol44 29 1210.6CHGA, NTS, SST, VIP, SCT, GAST
19forskolin44 50 1210.6GH1, CALCA, VIP, GHRH, CHGA, SCT
20gaba448.5GAST, NTS, SST, SCT, VIP, CHGA
21c-peptide448.5CHGA, GH1, GAST, NTS, SST, SCT
22corticosterone44 60 2510.5VIP, NTS, GH1, CALCA, GAST
235-hydroxytryptamine448.4VIP, CALCA, GAST, SST, CHGA, NTS
24nifedipine44 29 50 1211.3GAST, GH1, GHRH, NTS, SST, VIP
25lactate448.3SST, CALCA, CHGA, GH1, VIP, SMAD4
26acth448.1GHRH, GAST, GH1, NTS, SST, CHGA
27thymidine44 259.0MEN1, SMAD4, GAST, GH1, NTS, VIP
28vitamin d448.0GH1, CHGA, GAST, MEN1, GHRH, CALCA
29gnrh448.0SST, GHRH, VIP, NTS, GAST, GH1
30pge2447.9CALCA, SST, NTS, VIP, GAST, SCT
31atropine44 29 129.9GAST, CALCA, GHRH, NTS, SST, VIP
32thyroxine44 258.9CALCA, VIP, SST, NTS, SCT, GH1
33propranolol44 29 50 25 1211.9SST, GHRH, GH1, CALCA, GAST, VIP
34isoproterenol44 128.8SCT, CHGA, SST, GH1, CALCA, GAST
35acetylcholine44 50 29 25 1211.8GAST, SCT, VIP, CHGA, SST, CALCA
36dexamethasone44 50 29 1210.7CXCR4, GH1, GAST, GHRH, NTS, SST
37histamine44 29 259.7VIP, GAST, CALCA, NTS, SCT, SST
38norepinephrine44 25 129.6GHRH, GH1, CALCA, GAST, CHGA, NTS
39dopamine44 29 25 1210.6CHGA, GAST, CALCA, GH1, NTS, GHRH
40arginine447.4MSH2, SMAD4, SCT, VIP, CHGA, NTS
41glucose447.3GH1, NTS, GAST, CHGA, SST, CXCR4
42epinephrine44 25 129.3SCT, VIP, CHGA, SST, GAST, CALCA
43vegf447.1CHGA, MEN1, GH1, CALCA, SMAD4, VIP
44estrogen447.1GH1, SMAD4, GHRH, CALCA, GAST, MEN1
45octreotide44 60 29 1210.1SCT, GAST, CALCA, VIP, CHGA, SST
46adenylate447.1GAST, CALCA, GH1, GHRH, NTS, SST
47tyrosine447.0GAST, GH1, NTS, MEN1, SMAD4, CXCR4
48glutamate446.8CXCR4, GAST, CALCA, GHRH, NTS, SST
49testosterone44 60 25 129.7SMAD4, SCT, VIP, CHGA, CXCR4, SST
50serine446.4SMAD4, MEN1, SCT, VIP, CHGA, CXCR4

GO Terms for genes affiliated with Vipoma

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Cellular components related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.5CALCA, SST, VIP
2terminal boutonGO:0431959.5CALCA, GHRH
3extracellular regionGO:0055767.1GAST, SCT, VIP, CHGA, SST, NTS

Biological processes related to Vipoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GHRH, GH1
2hormone-mediated apoptotic signaling pathwayGO:0086289.9SSTR3, SST
3positive regulation of vasodilationGO:0459099.8CALCA, VIP
4positive regulation of multicellular organism growthGO:0400189.8GHRH, GH1
5positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.8MEN1, SMAD4
6adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8CALCA, GHRH
7positive regulation of cAMP biosynthetic processGO:0308199.5CALCA, GHRH
8germ cell developmentGO:0072819.2MSH2, CXCR4
9cell-cell signalingGO:0072679.2CALCA, GHRH, SSTR3, SST
10negative regulation of cell proliferationGO:0082859.1MEN1, SSTR3, SST, SMAD4
11G-protein coupled receptor signaling pathwayGO:0071868.8VIP, CXCR4, SST, GAST

Molecular functions related to Vipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.9NTS, VIP
2Y-form DNA bindingGO:0004039.5MSH2, MEN1
3R-SMAD bindingGO:0704129.4MEN1, SMAD4
4four-way junction DNA bindingGO:0004009.3MSH2, MEN1
5hormone activityGO:0051798.2GAST, CALCA, GH1, SST, VIP, SCT
6protein bindingGO:0055155.9SMAD4, VIP, CXCR4, MSH2, SSTR3, MEN1

Products for genes affiliated with Vipoma

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Sources for Vipoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet