MCID: VPM001
MIFTS: 46

Vipoma malady

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Vipoma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Vipoma:

Name: Vipoma 10 45 47 12 51 36 65
Pancreatic Cholera 51 65
Pancreatic Vipoma 45 65
Malignant Vasoactive Intestinal Peptide-Secreting Tumor 10
Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome 51
Vasoactive Intestinal Peptide-Secreting Tumor 10
Vasoactive Intestinal Peptide-Producing Tumor 45
Vasoactive Intestinal Peptide Tumor 45
 
Diarrheogenic Islet Cell Tumor 51
Verner-Morrison Syndrome 51
Vip- Secreting Tumor 10
Vip-Secreting Tumor 51
Vipoma, Malignant 10
Malignant Vipoma 65
Wdha Syndrome 51

Characteristics:

Orphanet epidemiological data:

51
vipoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:5574
MeSH36 D003969
NCIt42 C26749
Orphanet51 97282
ICD10 via Orphanet28 E16.8
MESH via Orphanet37 D003969
UMLS via Orphanet66 C0011993
UMLS65 C0011993, C1881600

Summaries for Vipoma

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NIH Rare Diseases:45 Vipoma is a rare cancer that develops within the pancreas. this tumor causes pancreatic cells to produce high levels of a hormone called vasoactive intestinal peptide (vip). the signs and symptoms of a vipoma include abdominal pain, flushing or redness of the face, nausea, watery diarrhea, weight loss, dehydration, and low blood potassium (hypokalemia). vipomas are usually diagnosed in adults around age 50. the cause of vipoma is unknown. treatment may include intravenous (iv) fluids to correct dehydration, medications such as octreotide to help control diarrhea, and surgery to remove the tumor. last updated: 3/8/2010

MalaCards based summary: Vipoma, also known as pancreatic cholera, is related to parathyroid adenoma and paralytic ileus, and has symptoms including diarrheaand diarrhea. An important gene associated with Vipoma is VIP (Vasoactive Intestinal Peptide), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and G alpha (s) signalling events. Affiliated tissues include pancreas, lung and thyroid.

Wikipedia:68 A VIPoma (also known as Verner–Morrison syndrome, after the physicians who first described it) is a... more...

Related Diseases for Vipoma

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Diseases related to Vipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1parathyroid adenoma29.9CALCA, CHGA
2paralytic ileus29.6NTS, SST, VIP
3pancreatic vasoactive intestinal peptide producing tumor11.3
4pancreatitis10.4
5duodenal benign neoplasm10.4SST, VIP
6osmotic diarrhea10.4SST, VIP
7birdshot chorioretinopathy10.4SST, VIP
8cluttering10.3CALCA, VIP
9atrophic rhinitis10.3CALCA, VIP
10large cell carcinoma with rhabdoid phenotype10.3CALCA, SST
11paroxysmal nocturnal hemoglobinuria10.3CALCA, SST
12lipoadenoma10.3CALCA, SST
13urinary system disease10.2CHGA, SST
14ischemic neuropathy10.2NTS, VIP
15alpha-methylacyl-coa racemase deficiency10.2SST, VIP
16craniodiaphyseal dysplasia10.2CALCA, SST
17villous adenocarcinoma10.2CHGA, SST
18kidney cancer10.2NTS, VIP
19scabies10.1CALCA, CHGA
20myopathy with deficiency of iron-sulfur cluster assembly enzyme10.1CHGA, VIP
21colloid carcinoma of the pancreas10.1CHGA, SST
22corneal ectasia10.1CALCA, CHGA
23diarrhea10.1
24lung occult small cell carcinoma10.1CALCA, CHGA
25hepatitis10.1
26clivus chordoma10.0CALCA, CHGA
27papillary follicular thyroid adenocarcinoma10.0CHGA, SST
28non-syndromic x-linked intellectual disability10.0CHGA, SST
29wdha syndrome10.0
30organ system cancer10.0CALCA, CHGA
31neonatal respiratory failure10.0SST, VIP
32pancreatic cystadenocarcinoma10.0SCT, SST
33senile angioma10.0SCT, SST
34ampulla of vater neoplasm10.0SCT, SST
35organ system benign neoplasm10.0CHGA, SST
36pancreatic cholera10.0
37weaver johnson syndrome10.0CALCA, SST, VIP
38glucose intolerance9.9SCT, SST
39spastic ataxia 19.9CHGA, SST
40glucagonoma9.9
41multiple endocrine neoplasia9.9
42duodenal disease9.9NTS, SCT
43hepatic flexure cancer9.9SCT, SST
44polyglucosan body disease, adult form9.9CALCA, SCT
45epidermolysis bullosa, pretibial9.8CALCA, SCT
46pancreatic lipomatosis duodenal stenosis9.8CALCA, NTS, SST
47hemangioma of peripheral nerve9.8CHGA, SST, VIP
48joint disorders9.8CHGA, SST, VIP
49localized pulmonary fibrosis9.8CALCA, CHGA, VIP
50ulcerative colitis9.8

Graphical network of the top 20 diseases related to Vipoma:



Diseases related to vipoma

Symptoms for Vipoma

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UMLS symptoms related to Vipoma:


diarrhea

Drugs & Therapeutics for Vipoma

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Drugs for Vipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Capecitabineapproved, investigationalPhase 21220154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
2
Dacarbazineapproved, investigationalPhase 24114342-03-45351166
Synonyms:
(5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
(5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
(Dimethyltriazeno)imidazolecarboxamide
37626-23-6
4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide
4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(Dimethyltriazeno)imidazole-5-c arboxamide
4-(Dimethyltriazeno)imidazole-5-carboxamide
4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide
4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide
4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide
4-[3,3-dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide
4342-03-4
5(or 4)-(dimethyltriazeno)imidazol e-4(or 5)-carboxamide
5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide
5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
5-(3,3-Dimethyltri azeno)imidazole-4-carboxamide
5-(3,3-Dimethyltriazeno)-imidazole-4-carbamide
5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
5-(Dimethyltriazeno)-4-imidazolecarboxamide
5-(Dimethyltriazeno)imidazole-4-carboxamide
5-(Dimethyltriazeno)imidazole-4-carboximide
5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide
94361-71-4
AC1NQXVV
AC1NS01W
AC1NS4BN
AI3-52825
BPBio1_000428
BRD-K35520305-001-07-8
BSPBio_000388
BSPBio_002091
Biocarbazin
Biocarbazine
Biocarbazine R
C6H10N6O
CAS-891986
CCRIS 190
CHEBI:4305
CHEMBL476
CID5281007
CID5351166
CID5353562
Carboxamide, Dimethyl Imidazole
D00288
D003606
D2390_SIGMA
D3634
DB00851
DIC
DTCI
DTIC
DTIC Dome
DTIC, DTIC-Dome, Dacarbazine
DTIC-Dome
DTICDome
DTIE
Dacarbazin
Dacarbazina
Dacarbazine
Dacarbazine (JAN/USP/INN)
Dacarbazine [USAN:INN:BAN:JAN]
Dacarbazino
Dacarbazino [INN-Spanish]
Dacarbazinum
Dacarbazinum [INN-Latin]
 
Dacatic
Decarbazine
Deticene
Di-me-triazenoimidazolecarboxamide
Di-methyl-triazenoimidazolecarboxamide
Dimethyl Imidazole Carboxamide
Dimethyl Triazeno Imidazole Carboxamide
Dimethyltriazenoimidazolecarboxamide
DivK1c_000326
Dtic-Dome
Dtic-Dome (TN)
Dtic-dome (tn)
EINECS 224-396-1
HE1150000
HMS1569D10
HMS2090A20
HMS2091I20
HMS501A08
HSDB 3219
I06-2280
I14-1659
ICDMT
ICDT
IDI1_000326
Imidazole Carboxamide
Imidazole Carboxamide, Dimethyl
Imidazole carboxamide
KBio1_000326
KBio2_001364
KBio2_003932
KBio2_006500
KBio3_001311
KBioGR_000896
KBioSS_001364
LS-119
MLS001332543
MLS001332544
MolPort-003-666-153
MolPort-003-846-120
MolPort-006-709-420
NCGC00016986-01
NCGC00091861-01
NCGC00091861-02
NCGC00091861-03
NCGC00091861-04
NCI-C04717
NCI60_004053
NCIMech_000261
NINDS_000326
NIOSH/HE1150000
NPFAPI-05
NSC 45388
NSC-45388
NSC45388
Prestwick0_000574
Prestwick1_000574
Prestwick2_000574
Prestwick3_000574
Prestwick_904
S1221_Selleck
SMP2_000251
SMR000857131
SPBio_001075
SPBio_002607
SPECTRUM1500218
ST51014976
Spectrum2_001148
Spectrum3_000366
Spectrum4_000308
Spectrum5_000823
Spectrum_000884
UNII-7GR28W0FJI
WLN: T5M CNJ DVZ ENUNN1&1
dacarbazine
3
Temozolomideapproved, investigationalPhase 266285622-93-15394
Synonyms:
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one
8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
85622-93-1
AC-758
AC1L1K9B
BIDD:GT0204
BRN 5547136
Bio-0147
C047246
C6H6N6O2
CCRG 81045
CCRG-81045
CCRIS 8996
CHEBI:153686
CHEMBL810
CID5394
CPD000466338
D06067
DB00853
Essex brand of temozolomide
HMS2051O12
HMS2090B08
I06-0149
I14-1943
LS-80558
M B 39831
M & B 39831
M&B 39831
M&B-39831
 
M-39831
MB 39831
MLS000759447
MLS001424028
MLS002701861
Methazolastone
NCGC00167429-01
NCGC00167429-02
NCI60_003316
NSC 362856
NSC-362856
NSC362856
SAM001246636
SMR000466338
STK623541
Sch 52365
Sch-52365
Schering brand of temozolomide
Schering-Plough brand of temozolomide
TL8005593
TMZ
TMZ-Bioshuttle
Temodal
Temodal (TN)
Temodar
Temozolamide
Temozolodida
Temozolodida [Spanish]
Temozolomid
Temozolomida
Temozolomide
Temozolomide (JAN/USAN/INN)
Temozolomide [INN:BAN]
Temozolomidum
Temozolomidum [Latin]
Témozolomide
UNII-YF1K15M17Y
ZINC01482184
m & b 39831
temozolomide
4
Epothilone Bexperimental, investigationalPhase 267152044-54-746936553
Synonyms:
EPO 906
 
EPO906
patupilone
5Antineoplastic Agents, AlkylatingPhase 23406
6Antimetabolites, AntineoplasticPhase 25770
7AntimetabolitesPhase 29454
8EpothilonesPhase 2114
9Tubulin ModulatorsPhase 24279
10Alkylating AgentsPhase 23582
11Antimitotic AgentsPhase 24296

Interventional clinical trials:

idNameStatusNCT IDPhase
1EPO906 in Carcinoid and Other Neuroendocrine TumorsCompletedNCT00050349Phase 2
2Capecitabine and Temozolomide for Neuroendocrine CancersCompletedNCT00869050Phase 2
3Gastroenteral-Pancreatic Neuroendocrine Tumors in TaiwanEnrolling by invitationNCT02102893

Search NIH Clinical Center for Vipoma


Cochrane evidence based reviews: vipoma

Genetic Tests for Vipoma

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Anatomical Context for Vipoma

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MalaCards organs/tissues related to Vipoma:

33
Pancreas, Lung, Thyroid, Prostate, Heart, Bone, Endothelial

Animal Models for Vipoma or affiliated genes

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Publications for Vipoma

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Articles related to Vipoma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
When Symptomatic Treatment Becomes Antitumor Treatment for Vipoma: Opportunity for Frail Elderly Adults. (26889855)
2016
2
Pancreatic VIPoma visualized by 68Ga DOTA-NOC PET-CT. (26235641)
2015
3
Metastatic VIPoma presenting as an ovarian mass. (26657531)
2015
4
Extra-pancreatic vipoma. (25184777)
2014
5
Sunitinib Achieved Fast and Sustained Control of VIPoma Symptoms. (25305306)
2014
6
Sporadic pancreatic vasoactive intestinal peptide-producing tumor (VIPoma) in a 47-year-old male. (24785507)
2014
7
Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma. (25349667)
2014
8
VIPoma in a 37-year-old man. (23993192)
2013
9
A rare cause of diarrhea: pancreatic VIPoma. (24008482)
2013
10
MSH2 and CXCR4 involvement in malignant VIPoma. (23231927)
2012
11
VIPoma that arose from the rectum in a 65-year-old male patient. (22350188)
2012
12
Benign pancreatic vipoma. (21526882)
2011
13
VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. (21509215)
2011
14
VIPoma syndrome: challenges in management. (20730389)
2010
15
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. (19387771)
2009
16
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
17
Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. (18662399)
2008
18
Diagnosis and treatment of VIPoma in a female patient. (16357627)
2006
19
Calcitonin-secreting VIPoma. (16416161)
2005
20
VIPomas: an update in diagnosis and management in a series of 11 patients. (16001675)
2005
21
Diagnosis and treatment of VIPoma in China: (case report and 31 cases review) diagnosis and treatment of VIPoma. (14707737)
2004
22
Jejunal vipoma]. (15646540)
2004
23
Vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases: dramatic and durable symptomatic benefit from hepatic artery embolization, a case report. (12482130)
2002
24
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. (11702127)
2001
25
Vasoactive Intestinal Peptide Tumor (VIPoma) (25905195)
2000
26
Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil. (10638600)
2000
27
The cost-effectiveness of octreotide acetate in the treatment of carcinoid syndrome and VIPoma. (9780538)
1998
28
Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. (10089056)
1998
29
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. (7914844)
1994
30
Intestinal uptake of Tc-99m MDP in a patient with vipoma syndrome. (8004871)
1994
31
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995). (8197564)
1994
32
Ondansetron and VIPoma. (8392671)
1993
33
Primary hepatic vipoma. (8389095)
1993
34
Vipoma of the pancreas complicating ulcerative colitis. (1650130)
1991
35
Vipoma in an adolescent: treatment with a delayed-action somatostatin analog, octreotide or SMS 201-995, and surgical removal]. (2176428)
1990
36
Vipoma of the pancreas. Apropos of a case and review of the literature]. (2167711)
1990
37
The somatostatin analogue SMS 201-995 in long-term treatment of vipoma. Case report. (2557717)
1989
38
Somatostatin analogue: use in the treatment of vipoma with hypercalcemia. (2549791)
1989
39
Paralytic ileus responding to somatostatin therapy: first manifestation of a VIPoma. (2573486)
1989
40
Somatostatin and analogues in the treatment of VIPoma. (2898913)
1988
41
A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report. (2847862)
1988
42
Somatostatin analogue SMS 201-995 long term therapy for vipoma. (2891127)
1987
43
VIPoma syndrome. (2820063)
1987
44
VIPoma syndrome. (3035922)
1987
45
Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma. (2986921)
1985
46
Regression of metastatic vipoma with somatostatin analogue SMS 201-995. (2858733)
1985
47
Vipoma. (6294887)
1982
48
Metastatic pancreatic vipoma: a case report of clinical response following treatment with corticosteroids and actinomycin D. (6286202)
1982
49
Vipoma: localisation by percutaneous transhepatic portal venous sampling. (737438)
1978
50
Proceedings: Investigation and treatment of a recurrent vipoma. (173625)
1975

Variations for Vipoma

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Expression for genes affiliated with Vipoma

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Search GEO for disease gene expression data for Vipoma.

Pathways for genes affiliated with Vipoma

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GO Terms for genes affiliated with Vipoma

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Cellular components related to Vipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.7NTS, SCT, SST

Biological processes related to Vipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:00459099.6CALCA, VIP
2response to yeastGO:00018789.6CALCA, VIP
3antifungal humoral responseGO:00197329.5CALCA, VIP
4antibacterial humoral responseGO:00197319.4CALCA, VIP
5defense response to Gram-negative bacteriumGO:00508299.3CALCA, CHGA
6cellular response to nerve growth factor stimulusGO:19900909.0CALCA, NTS

Sources for Vipoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet