MCID: VRL007
MIFTS: 51

Viral Encephalitis

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Viral Encephalitis

MalaCards integrated aliases for Viral Encephalitis:

Name: Viral Encephalitis 12 14 69
Encephalitis, Arbovirus 42
Arbovirus Encephalitis 69
Epidemic Encephalitis 12
Encephalitis Viral 52

Classifications:



External Ids:

Disease Ontology 12 DOID:646
MeSH 42 D004671
NCIt 47 C34576
UMLS 69 C0014055

Summaries for Viral Encephalitis

Disease Ontology : 12 An encephalitis that involves inflammation of the brain caused by viral infection.

MalaCards based summary : Viral Encephalitis, also known as encephalitis, arbovirus, is related to louping ill and rift valley fever. An important gene associated with Viral Encephalitis is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Formaldehyde and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Viral encephalitis is a type of encephalitis caused by a... more...

Related Diseases for Viral Encephalitis

Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Viral Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
id Related Disease Score Top Affiliating Genes
1 louping ill 30.2 CCL2 CXCL8 TNF
2 rift valley fever 29.9 IL1B IL6 TNF
3 conduct disorder 29.8 IL10 IL6 TNF
4 myelitis 29.5 CCL5 IL10 IL6
5 malaria 26.3 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
6 cerebral palsy 10.8
7 encephalitis 10.8
8 autoimmune polyglandular syndrome type 3 10.7 TNF VCAM1
9 aortic arch interruption 10.7 IL6 TNF
10 cutaneous leishmaniasis 10.7 IL6 TNF
11 toxoplasmosis 10.6 IL6 TNF
12 japanese encephalitis 10.6
13 dyslexia 5 10.6 IL6 TNF
14 tabatznik syndrome 10.6 IL1B TNF
15 sternal cleft 10.6 IL1B TNF
16 epstein-barr virus hepatitis 10.6 IL6 TNF
17 pulmonary hypertension 10.6 IL1B TNF
18 pure autonomic failure 10.6 IL10 TNF
19 anencephaly and spina bifida x-linked 10.6 IL6 TNF
20 acute ackee fruit intoxication 10.5 IL10 TNF
21 walker dyson syndrome 10.5 IL1B TNF
22 peroneal nerve paralysis 10.5 IL10 IL6
23 interval angle-closure glaucoma 10.5 CCL2 IL1B
24 papilledema 10.5 IL6 TNF
25 x-linked dominant intellectual disability-epilepsy syndrome 10.5 IL1B IL6
26 pulmonary plasma cell granuloma 10.5 IL1B VCAM1
27 cataract 10.5 IL1B TNF
28 multiple familial trichoepithelioma 10.5 IL10 TNF
29 lagophthalmos 10.5 IL10 TNF
30 pneumoconiosis due to talc 10.5 CCL2 TNF
31 type 1 papillary adenoma of the kidney 10.5 IL10 TNF
32 mental retardation, autosomal dominant 32 10.5 CCL2 IL1B
33 endosalpingiosis 10.5 IL10 TNF
34 vogt-koyanagi-harada disease 10.5 CXCL10 IL6 TNF
35 moved to 244450 10.4 IL1B TNF VCAM1
36 emphysema, congenital lobar 10.4 IL6 TNF VCAM1
37 urethral intrinsic sphincter deficiency 10.4 CCL2 TNF
38 scrotal carcinoma 10.4 IL1B IL6 TNF
39 focal dystonia 10.4 CCL2 IL6 VCAM1
40 upper gum cancer 10.4 IL1B IL6 TNF
41 bipolar i disorder 10.4 IL1B IL6 TNF
42 scleredema adultorum 10.4 IL6 VCAM1
43 tinea favosa 10.4 IL1B IL6 TNF
44 central nervous system leiomyosarcoma 10.4 IL1B IL6 TNF
45 indolent myeloma 10.4 IL1B IL6 TNF
46 idiopathic dilatation of the pulmonary artery 10.4 IL10 TNF
47 ampulla of vater neoplasm 10.4 IL1B IL6 TNF
48 benign neonatal seizures 10.4 IL1B IL6 TNF
49 keloids 10.4 IL1B IL6 TNF
50 brucella canis brucellosis 10.4 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Viral Encephalitis:



Diseases related to Viral Encephalitis

Symptoms & Phenotypes for Viral Encephalitis

MGI Mouse Phenotypes related to Viral Encephalitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 IL6 MBP MOG TNF VCAM1 CCL5
2 immune system MP:0005387 9.32 MBP MOG TNF VCAM1 CCL2 CCL5

Drugs & Therapeutics for Viral Encephalitis

Drugs for Viral Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Phase 4,Phase 3 50-00-0 712
2 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
3 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
4 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Disinfectants Phase 4,Phase 3
7 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
8 Antibodies, Blocking Phase 4,Phase 3,Phase 2
9 Blood Substitutes Phase 4
10 Plasma Substitutes Phase 4
11 Polygeline Phase 4
12
Famciclovir Approved Phase 3 104227-87-4 3324
13
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
14
Aluminum hydroxide Approved Phase 3,Phase 1 21645-51-2
15
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
16
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
17
Lactitol Investigational Phase 3 585-86-4 3871
18 Antimetabolites Phase 3,Phase 2
19 Antiviral Agents Phase 3,Phase 2,Phase 1
20 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
21 2-Aminopurine Phase 3
22 Acyclovir Phase 3
23 valacyclovir Phase 3
24 Gastrointestinal Agents Phase 3,Phase 1
25 Antimalarials Phase 3
26 Antiparasitic Agents Phase 3
27 Antiprotozoal Agents Phase 3
28 Antiemetics Phase 3
29 Autonomic Agents Phase 3
30 Hormone Antagonists Phase 3
31 Hormones Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Anti-Inflammatory Agents Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36 BB 1101 Phase 3
37 Dexamethasone acetate Phase 3 1177-87-3
38 glucocorticoids Phase 3
39 HIV Protease Inhibitors Phase 3
40
protease inhibitors Phase 3
41 Analgesics Phase 3
42 Analgesics, Non-Narcotic Phase 3
43 Anthelmintics Phase 3
44 Anti-Inflammatory Agents, Non-Steroidal Phase 3
45 Antirheumatic Agents Phase 3
46 Chloroquine diphosphate Phase 3 50-63-5
47
Ribavirin Approved Phase 2 36791-04-5 37542
48
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
49
Efavirenz Approved, Investigational Phase 2 154598-52-4 64139
50
Lamivudine Approved, Investigational Phase 2 134678-17-4 60825

Interventional clinical trials:

(show top 50) (show all 156)

id Name Status NCT ID Phase Drugs
1 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
2 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Unknown status NCT01398540 Phase 4
3 Kaiser Permanente HIV Cohort Study Completed NCT01339403 Phase 4
4 Cervicovaginal Immune Responses to 3 Deltoid or Thigh Intramuscular (IM) TicoVac Completed NCT01710189 Phase 4 TicoVac
5 Study to Investigate the Seropersistence of TBE Virus Antibodies Approx. 3 Years After a Booster Vaccination With FSME-IMMUN 0.25 mL JUNIOR in Children Completed NCT00163618 Phase 4
6 Tick-Borne Encephalitis (TBE) Seropersistence After First Booster in Children, Adolescents and Young Adults (Follow-Up to Study 700401) Completed NCT00894686 Phase 4
7 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX Completed NCT02526550 Phase 4
8 Post-licensure Safety Study of IMOJEV® in Thailand Completed NCT01981967 Phase 4
9 Influence of Persistent CMV-infection on Immune Senescence Completed NCT00461695 Phase 4
10 TBE Seropersistence up to 10 Years After First Booster in Adults Completed NCT01582698 Phase 4
11 TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223) Completed NCT00503529 Phase 4
12 Immunogenicity and Safety Study of a Third Vaccination With FSME-IMMUN 0.5 mL in Subjects Previously Vaccinated According to a Rapid Immunization Schedule (Follow-up to Study 225) Completed NCT00163540 Phase 4
13 Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines Completed NCT02643433 Phase 4
14 TBE Antibody Persistence and Booster Vaccination Study in Children and Adolescents (Follow-up to Study 209) Completed NCT00161967 Phase 4
15 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
16 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2 Completed NCT01656200 Phase 4
17 Long-term Immunogenicity and Safety of Fourth Administration of Boryung Cell-Culture Japanese Encephalitis Vaccineinj Completed NCT02532569 Phase 4
18 Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules Completed NCT01562444 Phase 4
19 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
20 An Extension Study to Determine the Persistence of Tick-borne Encephalitis (TBE)-Specific Antibody Responses Among Children and Adolescents Previously Immunized Against TBE Completed NCT01106482 Phase 4
21 Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose Completed NCT02514746 Phase 4
22 This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population Completed NCT01158599 Phase 4
23 Immunogenicity and Safety Study of a Rapid Immunization Schedule With FSME-IMMUN 0.5 mL in Healthy Adults Aged 16 - 65 Years Completed NCT00161954 Phase 4
24 Humoral and Cellular Immunity of Low and High-responders After Tick-borne Encephalitis Vaccination Completed NCT00804219 Phase 4
25 Evaluation of Long-Term Immunogenicity in Subjects Boosted With a TBE Vaccine for Adults Completed NCT00311493 Phase 4
26 Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children Completed NCT00311441 Phase 4
27 The Aim of This Study is to Investigate the Persistence of Antibody Response in Adults up to 15 Years After One Booster Dose of GlaxoSmithKline (GSK) Biologicals' Encepur Adults Vaccine Recruiting NCT03294135 Phase 4
28 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
29 A Study to Evaluate the One Year Long-term Persistence of Immune Responses Following Two Different Rabies Vaccine Post-exposure Regimens in Chinese Children Not yet recruiting NCT03192371 Phase 4
30 Immunogenicity and Safety of Inactivated Vero Cell Derived Japanese Encephalitis Vaccine in Thai Children Completed NCT01408537 Phase 3
31 Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age Completed NCT00463684 Phase 3
32 Boosterability of Live Attenuated Japanese Encephalitis (JE) Vaccine in Children Who Have Previously Received Inactivated JE Vaccine Completed NCT00463476 Phase 3
33 Determining Long-Term Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00412516 Phase 3
34 Determining Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00249769 Phase 3
35 Study of a Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV™) Compared to CD.JEVAX™ in Toddlers Completed NCT01396512 Phase 3
36 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
37 A Study of Japanese Encephalitis Chimeric Virus Vaccine Compared With SA14-14-2 Vaccine in Infants and Toddlers Completed NCT01092507 Phase 3
38 Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV Completed NCT01190228 Phase 3
39 Long-term Follow-up of Immunogenicity of a Single Dose of Japanese Encephalitis Chimeric Virus Vaccine in Toddlers Completed NCT01001988 Phase 3
40 Study of a Single Primary Dose Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV®) in Healthy Subjects Completed NCT02492165 Phase 3
41 Study of a Booster Dose of IMOJEV® Vaccine One Year After Primary Immunization in Healthy Children in South Korea Completed NCT01900444 Phase 3
42 A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVax™-JE and JE-VAX Completed NCT00314145 Phase 3
43 Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country Completed NCT01296360 Phase 3
44 Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population Completed NCT01041573 Phase 3
45 A Clinical Trial for Inactivated Japanese Encephalitis Vaccine in Healthy Chinese Infants Completed NCT02367664 Phase 3
46 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
47 Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines Completed NCT00735644 Phase 3
48 Immunogenicity and Safety Study of FSME-IMMUN 0.5 mL in Adult Subjects Previously Vaccinated According to a Rapid Immunization Schedule Completed NCT00460486 Phase 3
49 Concomitant Vaccination With the Japanese Encephalitis Vaccine IC51 and HARVIX® 1440 Completed NCT00596271 Phase 3
50 Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis. Completed NCT00314132 Phase 3

Search NIH Clinical Center for Viral Encephalitis

Cochrane evidence based reviews: encephalitis, arbovirus

Genetic Tests for Viral Encephalitis

Anatomical Context for Viral Encephalitis

MalaCards organs/tissues related to Viral Encephalitis:

39
Brain, T Cells, Liver, Lymph Node, Monocytes, Thalamus, B Cells

Publications for Viral Encephalitis

Articles related to Viral Encephalitis:

(show top 50) (show all 325)
id Title Authors Year
1
MicroRNA-125b in peripheral blood: a potential biomarker for severity and prognosis of children with viral encephalitis. ( 28502057 )
2017
2
Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. ( 28891812 )
2017
3
A Rare and Fatal Case of Viral Encephalitis in an Immunocompetent Host. ( 28183425 )
2017
4
The role and mechanism of NF-I_B in viral encephalitis of children. ( 28587430 )
2017
5
The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis. ( 28407741 )
2017
6
Progressive hippocampal sclerosis after viral encephalitis: Potential role of NMDA receptor antibodies. ( 28750305 )
2017
7
Viral encephalitis after haplo-identical hematopoietic stem cell transplantation: Causative viral spectrum, characteristics, and risk factors. ( 28129450 )
2017
8
An Increase of Cerebrospinal Fluid B-cell Activating Factor Level in Pediatric Patients With Acute Viral Encephalitis. ( 28259511 )
2017
9
Viral Encephalitis of Unknown Cause: Current Perspective and Recent Advances. ( 28587310 )
2017
10
Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. ( 28705180 )
2017
11
Seasonality of Viral Encephalitis and Associated Environmental Risk Factors in Son La and Thai Binh Provinces in Vietnam from 2004 to 2013. ( 27799646 )
2017
12
Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. ( 28291542 )
2017
13
Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis. ( 27209627 )
2016
14
A clinico-radiological study on viral encephalitis patients- A hospital based study. ( 27727853 )
2016
15
Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. ( 27307572 )
2016
16
Perspectives in Diagnosis and Treatment of Rabies Viral Encephalitis: Insights from Pathogenesis. ( 27324391 )
2016
17
Epidemiological surveillance of herpes viral encephalitis in Cordoba, Colombia. ( 28453063 )
2016
18
Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report. ( 27698716 )
2016
19
Microglia retard dengue virus-induced acute viral encephalitis. ( 27279150 )
2016
20
Post-malaria neurological syndrome or viral encephalitis? ( 26744539 )
2016
21
Neuroprotection mediated by inhibition of calpain during acute viral encephalitis. ( 27345730 )
2016
22
Differential Diagnosis of Restricted Diffusion of the Thalamus-Focus on Viral Encephalitis. ( 26425255 )
2015
23
Viral encephalitis in travellers. ( 25650207 )
2015
24
Probable toxic cause for suspected lychee-linked viral encephalitis. ( 25897979 )
2015
25
Early microlesion of viral encephalitis confirmed by galectin-3 expression after a virus inoculation. ( 25736950 )
2015
26
Clinical characteristics and outcome of clinically diagnosed viral encephalitis in southwest China. ( 26205533 )
2015
27
Influence of malnutrition on adverse outcome in children with confirmed or probable viral encephalitis: a prospective observational study. ( 25695076 )
2015
28
Viral encephalitis complicated by acute retinal necrosis syndrome: A case report. ( 26622338 )
2015
29
Herpes Simplex Viral Encephalitis Masquerading as a Classic Left MCA Stroke. ( 26770849 )
2015
30
Epidemiological features of viral encephalitis in Cangzhou of China with use of multiplex RT-PCR for five RNA viruses. ( 26118966 )
2015
31
The development of an intervention to promote adherence to national guidelines for suspected viral encephalitis. ( 25889994 )
2015
32
The evaluation of a tailored intervention to improve the management of suspected viral encephalitis: protocol for a cluster randomised controlled trial. ( 25623603 )
2015
33
Viral encephalitis and its management through advanced molecular diagnostic methods: a review. ( 23737611 )
2014
34
Case of the season: dural arteriovenous fistula mimicking a bithalamic neoplasm or viral encephalitis. ( 24342671 )
2014
35
Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report. ( 25120625 )
2014
36
Deep sequencing to identify the causes of viral encephalitis. ( 24699691 )
2014
37
Acute viral encephalitis co-existing with fulminant hepatitis caused by Epstein-Barr virus. ( 25041777 )
2014
38
Defining the chemokine basis for leukocyte recruitment during viral encephalitis. ( 24899190 )
2014
39
Immune system's role in viral encephalitis. ( 25189678 )
2014
40
Acute psychosis followed by fever--malignant neuroleptic syndrome or viral encephalitis? ( 25039118 )
2014
41
Clinical presentation of severe viral encephalitis with known causative agents in children: a retrospective study on 16 patients hospitalized in a pediatric intensive care unit (2008-2011). ( 24464514 )
2014
42
Clinical approach to the syndromes of viral encephalitis, myelitis, and meningitis. ( 25015482 )
2014
43
Gliomatosis cerebri mimicking viral encephalitis in a 4-year-old child. ( 24717581 )
2014
44
Secondary viral encephalitis in a patient with pyogenic liver abscess. ( 24967776 )
2014
45
Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis. ( 25300175 )
2014
46
Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis. ( 24530381 )
2014
47
Neuroimaging of six neurosyphilis cases mimicking viral encephalitis. ( 24007871 )
2013
48
Underreporting of viral encephalitis and viral meningitis, Ireland, 2005-2008. ( 23965781 )
2013
49
Mosquito-Host Interactions during and after an Outbreak of Equine Viral Encephalitis in Eastern Panama. ( 24339965 )
2013
50
Acute viral encephalitis. ( 23622326 )
2013

Variations for Viral Encephalitis

Expression for Viral Encephalitis

Search GEO for disease gene expression data for Viral Encephalitis.

Pathways for Viral Encephalitis

Pathways related to Viral Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
2
Show member pathways
13.79 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
3
Show member pathways
13.63 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
4
Show member pathways
13.49 CCL2 CCL5 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.39 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
6
Show member pathways
13.32 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
7
Show member pathways
13.29 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
8
Show member pathways
12.99 CCL2 CCL5 CXCL8 IL1B IL6 TNF
9
Show member pathways
12.87 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
10
Show member pathways
12.85 CXCL8 IL10 IL1B IL6 TNF
11
Show member pathways
12.82 CCL2 CCL5 CXCL10 CXCL8 IL1B IL6
12
Show member pathways
12.76 CCL5 CXCL10 CXCL8 IL1B IL6 TNF
13
Show member pathways
12.61 CCL2 IL10 IL1B IL6 TNF
14 12.59 CCL2 CCL5 CXCL10 IL10 IL1B TNF
15
Show member pathways
12.56 IL10 IL1B IL6 TNF
16
Show member pathways
12.42 IL10 IL1B IL6 TNF
17
Show member pathways
12.39 CCL2 CXCL10 CXCL8 IL1B IL6 TNF
18
Show member pathways
12.29 CXCL8 IL1B IL6 TNF
19 12.26 IL10 IL1B IL6 TNF
20
Show member pathways
12.23 CXCL10 CXCL8 IL1B IL6 TNF
21 12.22 CXCL8 IL10 IL1B IL6 TNF
22
Show member pathways
12.22 CXCL8 IL10 IL1B IL6 MX1 TNF
23 12.13 CCL2 IL1B TNF VCAM1
24
Show member pathways
12.06 CCL2 CCL5 CXCL10 CXCL8
25
Show member pathways
11.99 IL10 IL1B IL6 TNF
26 11.99 CCL2 CXCL10 CXCL8 IL1B IL6 MBP
27 11.97 IL10 IL6 TNF
28 11.97 CXCL8 IL10 IL1B IL6 TNF
29 11.93 CXCL8 IL1B TNF VCAM1
30 11.93 CCL2 CXCL8 IL1B IL6 TNF VCAM1
31 11.92 CXCL8 IL1B IL6
32 11.92 CCL2 CXCL8 IL10 IL1B IL6 TNF
33 11.88 IL1B IL6 TNF
34 11.86 CCL2 CCL5 CXCL8 IL1B IL6 TNF
35 11.85 CXCL8 IL10 IL1B IL6 TNF
36 11.83 CXCL8 IL1B IL6
37 11.83 CCL2 CCL5 CXCL10 IL1B IL6 TNF
38 11.82 IL10 IL1B IL6 TNF
39 11.79 IL10 IL1B TNF
40 11.78 IL10 IL6 TNF VCAM1
41
Show member pathways
11.76 CXCL8 IL1B IL6 TNF VCAM1
42 11.68 CCL2 CCL5 CXCL8 IL1B IL6 TNF
43 11.67 CXCL8 IL1B IL6 TNF
44 11.56 CCL2 IL1B TNF
45 11.53 IL1B IL6 TNF
46 11.45 IL10 IL1B IL6 TNF
47 11.42 IL10 IL1B IL6 TNF VCAM1
48 11.41 CCL5 IL1B IL6
49 11.4 CCL2 CXCL8 IL6
50 11.38 IL10 IL1B IL6 TNF

GO Terms for Viral Encephalitis

Cellular components related to Viral Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCL10 IL6 TNF VCAM1
3 extracellular space GO:0005615 9.28 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B

Biological processes related to Viral Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 CCL2 CCL5 IL1B MBP TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CCL5 IL6 TNF
3 aging GO:0007568 9.94 CCL2 IL10 IL6 VCAM1
4 cytokine-mediated signaling pathway GO:0019221 9.92 CCL2 IL1B IL6
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TNF
6 chemotaxis GO:0006935 9.91 CCL2 CCL5 CXCL10 CXCL8
7 defense response GO:0006952 9.9 CXCL10 CXCL8 MX1 TNF
8 response to virus GO:0009615 9.88 CCL5 CXCL10 MX1 TNF
9 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
10 regulation of insulin secretion GO:0050796 9.86 CCL5 IL1B TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 CCL5 IL6 TNF
12 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
13 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 CCL5 IL1B TNF
14 cellular response to interleukin-1 GO:0071347 9.84 CCL2 CCL5 CXCL8 IL6
15 positive regulation of cell adhesion GO:0045785 9.83 CCL2 CCL5 TNF
16 chemokine-mediated signaling pathway GO:0070098 9.83 CCL2 CCL5 CXCL10 CXCL8
17 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL6 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B IL6 TNF
19 monocyte chemotaxis GO:0002548 9.81 CCL2 CCL5 IL6
20 response to glucocorticoid GO:0051384 9.81 CCL2 IL10 IL6 TNF
21 negative regulation of viral genome replication GO:0045071 9.8 CCL5 MX1 TNF
22 cell chemotaxis GO:0060326 9.8 CCL2 CCL5 CXCL10 VCAM1
23 cellular response to tumor necrosis factor GO:0071356 9.8 CCL2 CCL5 CXCL8 IL6 VCAM1
24 cellular response to estradiol stimulus GO:0071392 9.78 CCL2 IL10 IL6
25 neutrophil chemotaxis GO:0030593 9.78 CCL2 CCL5 CXCL8 IL1B
26 cellular response to fibroblast growth factor stimulus GO:0044344 9.77 CCL2 CCL5 CXCL8
27 negative regulation of myoblast differentiation GO:0045662 9.75 CXCL10 TNF
28 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.75 IL10 TNF
29 positive regulation of interleukin-6 secretion GO:2000778 9.74 IL1B MBP
30 defense response to protozoan GO:0042832 9.74 IL10 IL6
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.74 IL1B TNF
32 positive regulation of JAK-STAT cascade GO:0046427 9.74 CCL5 IL6
33 embryonic digestive tract development GO:0048566 9.73 CXCL8 TNF
34 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
35 positive regulation of chemokine production GO:0032722 9.73 IL6 TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
37 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
38 leukocyte tethering or rolling GO:0050901 9.73 TNF VCAM1
39 positive regulation of monocyte chemotaxis GO:0090026 9.73 CCL2 CCL5 CXCL10
40 positive regulation of T cell proliferation GO:0042102 9.73 CCL5 IL1B IL6 VCAM1
41 response to lipopolysaccharide GO:0032496 9.73 CCL2 CXCL10 IL10 IL1B IL6 VCAM1
42 positive regulation of T cell migration GO:2000406 9.72 CCL5 CXCL10
43 positive regulation of macrophage chemotaxis GO:0010759 9.72 CCL2 CCL5
44 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 IL10 IL6
45 acute inflammatory response GO:0002526 9.72 IL6 VCAM1
46 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
47 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
48 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
49 response to auditory stimulus GO:0010996 9.71 CXCL10 IL6
50 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8

Molecular functions related to Viral Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8
2 cytokine activity GO:0005125 9.23 CCL2 CCL5 CXCL10 CXCL8 IL10 IL1B

Sources for Viral Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
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37 KEGG
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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70 UMLS via Orphanet
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