MCID: VRL010
MIFTS: 64

Viral Hepatitis malady

Infectious diseases, Gastrointestinal diseases, Liver diseases, Rare diseases, Immune diseases categories

Summaries for Viral Hepatitis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are African trypanosomiasis and Death Receptor Signalling. The compounds hepaplastin and adefovir have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:9 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:66 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 26ICD10
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Classifications:



Aliases & Descriptions:

viral hepatitis 9 11 46 63
unspecified viral hepatitis with hepatic coma 9
viral hepatitis with hepatic coma 9
hepatitis, viral, animal 63
hepatitis, viral, human 63
animal viral hepatitis 9
human viral hepatitis 9


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Disease Ontology9 DOID:1884
MeSH36 D006524

Related Diseases for Viral Hepatitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis B
Hepatitis D Hepatitis a
Hepatitis E Hepatitis
viral hepatitis Hepatitis C Virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.3GPT, SLC17A5
2hepatitis a31.5F2
3hepatitis b31.4ABCB7, GPT, AFP, IFNA2, SLC17A5, F2
4hepatitis c31.0SLC17A5, ABCB7, IFNA2, UROD, F2, FAS
5hepatocellular carcinoma30.8ABCB7, CISH, SLC17A5, F2, GPT, AFP
6hepatitis e30.8GPT, CD40LG
7alcohol abuse30.5GPT, SLC17A5, ABCB7
8fatty liver disease30.5ABCB7, GPT, SLC17A5
9hepatitis d30.4IFNA2, GPT
10cholestasis30.4GPT, SLC17A5, ABCB7, F2
11liver cirrhosis30.4SLC17A5, IFNA2, AFP, GPT, ABCB7, F2
12acute pancreatitis30.4SLC17A5, GPT, ABCB7
13autoimmune hepatitis30.2GPT, SLC17A5, CD40LG, FAS, F2, SEPSECS
14autoimmune hemolytic anemia30.2G6PD, CD40LG
15thrombocytopenia30.2IFNA2, ABCB7, SLC17A5, GPT, F2, CD40LG
16cholecystitis30.1GPT
17alcoholic liver cirrhosis30.1AFP, GPT
18siderosis30.1GPT, UROD
19acute liver failure30.1F2, SLC17A5, GPT
20portal hypertension30.1SLC17A5, GPT, F2
21alcoholic hepatitis30.1F2, SLC17A5, GPT
22hepatic encephalopathy30.1GPT, F2, SLC17A5
23vogt-koyanagi-harada disease30.0FASLG, FAS
24scrub typhus30.0GPT, SLC17A5, CD40LG
25cryoglobulinemia30.0SLC17A5, CD40LG, IFNA2
26obesity29.9CISH, ABCB7, GPT, SLC17A5
27fulminant viral hepatitis10.9
28liver disease10.5
29hepatic coma10.5
30cholangiocarcinoma10.4
31intrahepatic cholangiocarcinoma10.4
32tuberculosis10.4
33hepatitis c virus10.4
34hiv/aids10.4
35thyroiditis10.3
36porphyria10.3
37insulin resistance10.3
38endotheliitis10.3
39lichen planus10.2
40bronchitis10.2
41porphyria cutanea tarda10.2
42typhoid fever10.2
43acute orbital inflammation10.2
44hemolytic anemia10.2
45pancreatitis10.2
46blindness10.2
47polyarteritis nodosa10.1IFNA2
48intrahepatic cholestasis10.1
49pure red-cell aplasia10.1
50extrahepatic cholestasis10.1

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Symptoms for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Viral Hepatitis

Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Search CenterWatch for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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34MalaCards
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MalaCards organs/tissues related to Viral Hepatitis:

34
Liver, Testes, Kidney, Thyroid, T cells, Endothelial, Bone, Nk cells, Heart, Spleen, Monocytes, Pancreas, Breast, Colon, Spinal cord, Brain, Salivary gland

Animal Models for Viral Hepatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Viral Hepatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.7CD40LG, FASLG, FAS, CISH, AFP
2MP:00053857.2F2, ABCB7, G6PD, FAS, FASLG, CD40LG
3MP:00053977.1F2, CISH, G6PD, FAS, FASLG, CD40LG
4MP:00053847.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
5MP:00036317.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
6MP:00107686.4F2, ABCB7, AFP, G6PD, FAS, FASLG
7MP:00053766.0SLC17A5, F2, ABCB7, AFP, CISH, G6PD

Publications for Viral Hepatitis

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53PubMed
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Articles related to Viral Hepatitis:

(show top 50)    (show all 885)
idTitleAuthorsYear
1
Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis. (24383922)
2014
2
Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology. (24032050)
2013
3
Chronic viral hepatitis is associated with low bone mineral density in HIV-infected patients, ANRS CO 3 Aquitaine Cohort. (23296138)
2013
4
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
5
Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma. (23983238)
2013
6
Aplastic anemia following viral hepatitis. (24201921)
2013
7
A practical scoring system for predicting cirrhosis in patients with chronic viral hepatitis. (23178625)
2012
8
Maternal and perinatal outcome in cases of fulminant viral hepatitis in late pregnancy. (22947378)
2012
9
The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil. (23270376)
2012
10
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
11
Hematologic and biochemical indices and viral hepatitis in liver transplant patients. (21440777)
2011
12
Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis. (21883739)
2011
13
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
14
Reactivation of viral hepatitis in immunosuppressed patients: an ounce of prevention is worth a pound of cure. (21093439)
2011
15
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
16
Establishment of a viral hepatitis surveillance system--Pakistan, 2009-2011. (21993343)
2011
17
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
18
Assessment of validity of INR system for patients with liver disease associated with viral hepatitis. (19915802)
2010
19
At last a global response to viral hepatitis. (21076557)
2010
20
Determination of the relationship of serum hyaluronic Acid levels to the degree of liver fibrosis in biopsies of patients with chronic viral hepatitis B and C. (22308134)
2010
21
Advances in viral hepatitis: 50 years of Australian gastroenterology. (19799691)
2009
22
Viral hepatitis in solid organ transplant recipients. (20070671)
2009
23
HIV/viral hepatitis coinfection: the Immunology Center experience. (19685638)
2009
24
Vascular and glomerular manifestations of viral hepatitis B and C: a review. (19891305)
2009
25
Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. (18795698)
2008
26
HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in the Czech population. (17573946)
2007
27
Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. (17192324)
2007
28
Relationship of CT manifestations of chronic viral hepatitis with severity of illness]. (15760552)
2005
29
Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases. (16226105)
2005
30
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
31
Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C. (15232637)
2004
32
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
33
Influence of plasma exchange on serum cytokines in severe viral hepatitis patients]. (12857473)
2003
34
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
35
Apoptosis in viral hepatitis B and C. (11480324)
2001
36
Surveillance for hepatocellular carcinoma in patients with chronic viral hepatitis in the United States of America. (11350553)
2001
37
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. (11355694)
2001
38
Changes in the levels of acute phase proteins in viral hepatitis]. (11270948)
2000
39
Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? (11054721)
2000
40
Albumin gradient and portal vein velocity in severe viral hepatitis patients complicated with ascites. (11149035)
2000
41
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999
42
Host factors in chronic viral hepatitis. (9408970)
1997
43
The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. (8871871)
1996
44
Relation between treatment efficacy and cumulative dose of alpha interferon in chronic hepatitis B. European Concerted Action on Viral Hepatitis (Eurohep). (9007705)
1996
45
Interferon and cyclosporin A in the treatment of fulminant viral hepatitis. (7719417)
1995
46
Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis. (1907761)
1991
47
Measurement of serum alcohol dehydrogenase activity at different pH-values during the course of viral hepatitis in children. (2230670)
1990
48
Antibodies to hepatitis C virus in non-A non-B fulminant viral hepatitis. (2112102)
1990
49
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon. (3897068)
1985
50
Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor. (6402856)
1983

Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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Sources:
51PathCards, 31KEGG, 56Reactome, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 5Cell Signaling Technology, 58SinoBiological, 54QIAGEN
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Pathways related to Viral Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FASLG, FAS
2
Show member pathways
9.3FASLG, FAS
3
Show member pathways
9.3FAS, FASLG
4
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0IFNA2, FASLG, FAS
5
Show member pathways
Immune response CD16 signaling in NK cells61
9.0IFNA2, FASLG, FAS
68.9FASLG, FAS, CISH
7
Show member pathways
8.5FAS, FASLG, CD40LG
8
Show member pathways
8.2CD40LG, IFNA2, FASLG, FAS
9
Show member pathways
8.0F2, FAS, FASLG, IFNA2, CD40LG

Compounds for genes affiliated with Viral Hepatitis

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 3BitterDB, 25HMDB, 62Tocris Bioscience
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Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1hepaplastin4610.0F2, GPT, SLC17A5
2adefovir469.8GPT, IFNA2, SLC17A5
3aminopyrine469.8F2, SLC17A5, GPT
4lamivudine46 52 1211.7F2, GPT, IFNA2, SLC17A5
5silymarin469.5SLC17A5, GPT, F2, ABCB7
6nevirapine46 52 1211.4GPT, SLC17A5, ABCB7
7gamma globulin469.3IFNA2, CD40LG, SLC17A5
8phenobarbital46 30 52 1212.2SLC17A5, GPT, G6PD, UROD
9acetaminophen46 3 52 25 1213.2GPT, F2, G6PD, SLC17A5, AFP
10azathioprine46 3 52 1212.1AFP, G6PD, IFNA2, GPT
11simvastatin46 52 62 30 25 1214.1AFP, FASLG, GPT, F2, SLC17A5
12vitamin-e469.1GPT, G6PD, IFNA2, SLC17A5, ABCB7
13methotrexate52 46 1211.0SLC17A5, FASLG, GPT, F2, AFP
14neopterin469.0SLC17A5, CD40LG, IFNA2, GPT
15uric acid46 2510.0SLC17A5, ABCB7, GPT, G6PD, AFP
16ifn-alpha468.8CISH, FASLG, IFNA2, FAS, GPT
17mitomycin c468.7IFNA2, AFP, FAS, FASLG
18vitamin b12468.7SLC17A5, GPT, AFP, G6PD, CD40LG
19hyaluronic acid46 259.6FASLG, F2, CD40LG, GPT, SLC17A5
20thalidomide46 52 62 1211.6FASLG, AFP, IFNA2, CD40LG
21ethanol46 52 25 1211.5FASLG, ABCB7, GPT, AFP, UROD, SLC17A5
22vitamin a46 25 1210.5FAS, SLC17A5, CD40LG, IFNA2, GPT
23ursodeoxycholic acid46 25 1210.5CD40LG, IFNA2, ABCB7, F2, SLC17A5, GPT
24ribavirin46 52 1210.4GPT, SLC17A5, G6PD, IFNA2, CD40LG, AFP
25polyethylene glycol468.4IFNA2, F2, AFP, SLC17A5, G6PD, CD40LG
26tamoxifen46 52 30 1211.4FASLG, F2, G6PD, SLC17A5, FAS, IFNA2
27ivig468.4GPT, SEPSECS, FAS, FASLG, CD40LG
28fibrinogen468.3SLC17A5, CD40LG, AFP, GPT, F2, ABCB7
29iron46 259.3IFNA2, SLC17A5, UROD, ABCB7, GPT, AFP
30phosphatidylserine46 30 1210.1F2, G6PD, FASLG, FAS, CD40LG
31thyroxine46 258.9ABCB7, GPT, AFP, CD40LG, G6PD, SLC17A5
32ascorbic acid46 258.9FASLG, SLC17A5, IFNA2, FAS, CD40LG, G6PD
33oxygen46 258.8IFNA2, ABCB7, AFP, G6PD, FAS, SLC17A5
34agar467.8FASLG, AFP, G6PD, FAS, CD40LG, IFNA2
35cyclosporin a46 30 629.8GPT, SEPSECS, F2, FAS, FASLG, CD40LG
36lipid467.8ABCB7, SLC17A5, IFNA2, G6PD, CISH, AFP
37doxorubicin46 52 129.7AFP, CD40LG, G6PD, IFNA2, FASLG, FAS
38glucose467.7FASLG, G6PD, IFNA2, SLC17A5, AFP, ABCB7
39n acetylcysteine467.7GPT, FAS, F2, SLC17A5, G6PD, CD40LG
40alanine467.5CD40LG, FASLG, AFP, GPT, ABCB7, F2
41cisplatin46 52 62 1210.5SLC17A5, CD40LG, FASLG, AFP, G6PD, FAS
42heparin46 30 25 1210.4FASLG, CD40LG, F2, ABCB7, FAS, AFP
43estrogen467.4F2, CD40LG, UROD, AFP, CISH, G6PD
44actinomycin d467.4FASLG, CD40LG, FAS, AFP, G6PD
45creatinine467.3CD40LG, ABCB7, F2, SLC17A5, GPT, AFP
46epinephrine46 25 129.3AFP, F2, FAS, IFNA2, CD40LG, SLC17A5
47testosterone46 62 25 1210.2FASLG, FAS, G6PD, AFP, ABCB7, CD40LG
48serine466.9F2, FAS, AFP, CISH, FASLG, CD40LG
49lactate466.8F2, GPT, AFP, G6PD, FAS, ABCB7
50aspartate466.5CD40LG, SLC17A5, IFNA2, FASLG, AFP, G6PD

GO Terms for genes affiliated with Viral Hepatitis

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17Gene Ontology
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Cellular components related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CD40LG, FASLG, FAS
2extracellular spaceGO:0056157.9CD40LG, IFNA2, FASLG, AFP, F2

Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.4FASLG, FAS
2necroptotic signaling pathwayGO:0975279.4FASLG, FAS
3extrinsic apoptotic signaling pathwayGO:0971919.3FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.2FAS, FASLG
5positive regulation of endothelial cell apoptotic processGO:20003539.1CD40LG, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.0FASLG, FAS

Molecular functions related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1CD40LG, FASLG
2cytokine activityGO:0051258.5CD40LG, IFNA2, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Viral Hepatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet