MCID: VRL010
MIFTS: 61

Viral Hepatitis malady

Infectious diseases category

Summaries for Viral Hepatitis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are Allograft rejection and Toll-like receptor signaling pathway. The compounds alanine and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:63 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

viral hepatitis 8 10 44 60
unspecified viral hepatitis with hepatic coma 8
viral hepatitis with hepatic coma 8
hepatitis, viral, animal 60
hepatitis, viral, human 60
animal viral hepatitis 8
human viral hepatitis 8


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Disease Ontology8 DOID:1884
MeSH34 D006524

Related Diseases for Viral Hepatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a Hepatitis
viral hepatitis Hepatitis C Virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.1IFNA1, GPT, SLC17A5
2hepatitis a31.7F2
3hepatitis c31.5HFE, CD40LG, GPT, ABCB7, F2, SLC17A5
4hepatitis b31.5ABCB7, F2, SLC17A5, GGT1, PTMA, TMPO
5hepatocellular carcinoma31.1CISH, AFP, HFE, GPT, ABCB7, F2
6hepatitis e31.0CD40LG, GPT
7alcoholic hepatitis30.8GPT, F2, SLC17A5, GGT1
8autoimmune hepatitis30.7SEPSECS
9cholangiocarcinoma30.6GGT1, AFP
10liver cirrhosis30.5SEPSECS, PTMA, IFNA2, IFNA1, AKR1A1, CISH
11tuberculosis30.5AKR1A1
12thyroiditis30.4FASLG, IFNA1
13alcohol abuse30.3AKR1A1, HFE, GPT, ABCB7, SLC17A5, GGT1
14cholestasis30.3GPT, ABCB7, F2, SLC17A5, GGT1
15fatty liver disease30.3HFE, GPT, ABCB7, SLC17A5, GGT1
16porphyria30.3HFE, UROD
17hepatitis d30.3IFNA2, IFNA1, GPT
18thrombocytopenia30.2IFNA2, IFNA1, HFE, CD40LG, GPT, ABCB7
19acute pancreatitis30.2SLC17A5, ABCB7, GPT
20pancreatitis30.2SLC17A5, GGT1
21porphyria cutanea tarda30.2HFE, UROD
22lichen planus30.2IFNA2
23hemolytic anemia30.2IFNA2, G6PD, HFE
24viral infectious disease30.1IFNA2, IFNA1, FAS, FASLG, UROD, G6PD
25diabetes mellitus30.1G6PD, HFE, CD40LG, GPT, GGT1
26hypertension30.1GGT1, F2
27herpes simplex30.1TMPO, IFNA1
28malaria30.1G6PD
29acute liver failure30.1GPT, F2, SLC17A5
30influenza30.1TMPO, IFNA1
31autoimmune hemolytic anemia30.1CD40LG, G6PD
32alcohol dependence30.1GGT1
33vitiligo30.1G6PD
34breast cancer29.9FAS, G6PD, AKR1A1, CISH, PTMA, TMPO
35obesity29.9CISH, HFE, GPT, ABCB7, SLC17A5, GGT1
36cryoglobulinemia29.9IFNA2, IFNA1, CD40LG, SLC17A5
37portal hypertension29.9GPT, F2, SLC17A5, GGT1
38multiple sclerosis29.9IFNA1, FASLG, TMPO
39peritonitis29.9F2
40arthritis29.9HFE, CISH
41schistosomiasis29.9CD40LG
42scrub typhus29.9CD40LG, GPT, SLC17A5
43siderosis29.9UROD, HFE, GPT
44colon cancer29.9FASLG, FAS
45hemochromatosis29.9HFE, UROD
46hepatic encephalopathy29.9GPT, F2, SLC17A5
47cholecystitis29.9GPT
48alcoholic liver cirrhosis29.9AFP, GPT
49vogt-koyanagi-harada disease29.9FASLG, FAS
50glomerulonephritis29.9CD40LG

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Clinical Features for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Viral Hepatitis

Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Search CenterWatch for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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32MalaCards
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MalaCards organs/tissues related to Viral Hepatitis:

32
Liver, Kidney, Testes, T cells, Thyroid, Endothelial, Nk cells, Monocytes, Bone, Heart, Spinal cord, Spleen, Colon, B cells, Lymph node, Brain, Breast, Salivary gland, Pancreas

Animal Models for Viral Hepatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Viral Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8GGT1, FAS, FASLG, UROD, G6PD, AKR1A1
2MP:000539710.8FASLG, G6PD, AKR1A1, HFE, CD40LG, F2
3MP:001076810.6AKR1A1, G6PD, UROD, FASLG, FAS, AFP

Publications for Viral Hepatitis

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Sources:
50PubMed
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Articles related to Viral Hepatitis:

(show top 50)    (show all 1368)
idTitleAuthorsYear
1
MicroRNAs and liver disease: viral hepatitis, liver fibrosis and hepatocellular carcinoma. (24243965)
2014
2
Comparative analysis of hepatitis B virus polymerase sequences required for viral RNA binding, RNA packaging, and protein priming. (24227865)
2014
3
Residues Arg703, Asp777, and Arg781 of the RNase H Domain of Hepatitis B Virus Polymerase Are Critical for Viral DNA Synthesis. (24131721)
2014
4
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. (24127924)
2013
5
Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection. (24073315)
2013
6
Viral hepatitis: is it the end of the line for interferon therapy for hepatitis C? (24247259)
2013
7
Early prognostic markers for fatal fulminant hepatic failure cases with viral hepatitis: proton nuclear magnetic resonance spectroscopic studies of serum. (23122710)
2013
8
Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion. (23242209)
2013
9
Prevalence of viral hepatitis (B and C) serological markers in healthy working population. (23971655)
2013
10
Erectile dysfunction in patients with chronic viral hepatitis: a systematic review of the literature. (24215104)
2013
11
Role of molecular diagnostics in the management of viral hepatitis B. (23480805)
2012
12
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. (22737229)
2012
13
The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women. (21606539)
2011
14
Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/I^-catenin signaling. (20971552)
2011
15
The influence of interferon alpha on the induction of autoimmune thyroiditis in patients treated for chronic viral hepatitis type C. (22144218)
2011
16
Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. (21745311)
2011
17
Viral hepatitis A, active component, U.S. Armed Forces, 2000-2010. (21879784)
2011
18
World Hepatitis Day to tackle viral hepatitis. (21916031)
2011
19
Impact of immunosuppression and chemotherapy on reactivation of viral hepatitis. (20587863)
2010
20
Overview of the viral hepatitis problem. (20398585)
2010
21
Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis. (20167986)
2010
22
2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (20074559)
2010
23
Advances in viral hepatitis: 50 years of Australian gastroenterology. (19799691)
2009
24
Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis. (19856479)
2009
25
Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels. (19430095)
2009
26
Acute pancreatitis associated with acute viral hepatitis: case report and review of literature. (20209272)
2009
27
Chronic hepatitis B: preventing, detecting, and managing viral resistance. (18328434)
2008
28
Detection of markers of hepatitis viral infection in the tissue of bile duct carcinoma. (18706237)
2008
29
Imbalance between expression of endothelin receptors A and B in terminal liver cirrhosis due to hepatitis C viral infection: immunohistochemical study of autopsy cases. (17565586)
2008
30
A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. (17686842)
2007
31
Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence. (17079285)
2007
32
Hepatitis C virus superinfection in hepatitis B virus chronic carriers: a reciprocal viral interaction and a variable clinical course. (16316779)
2006
33
Genetic polymorphisms of interleukin-1-beta in association with sustained response to anti-viral treatment in chronic hepatitis B in Chinese. (16817913)
2006
34
Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C. (16475996)
2006
35
Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C. (15816475)
2005
36
Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistance. (16181053)
2005
37
West Nile viral encephalitis mimicking hepatic encephalopathy. (15647737)
2005
38
Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. (14707465)
2003
39
Apoptosis in viral hepatitis B and C. (11480324)
2001
40
Reactivation of viral replication after liver resection in patients infected with hepatitis B virus. (11141236)
2001
41
The impact of chronic hepatitis B viral infection on gastrointestinal motility. (11007135)
2000
42
Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP). (10385667)
1999
43
Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. (8533458)
1995
44
Cellular and humoral immune reactions against autoantigens and hepatitis C viral antigens in chronic hepatitis C. (7523226)
1994
45
Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. (7518526)
1994
46
Relationship between porphyria cutanea tarda (PCT) and viral hepatitis. (7914899)
1994
47
IFN in the treatment of chronic viral hepatitis. Efficacy and tolerance of lymphoblastoid alpha interferon in HIV-negative drug addicts and associated chronic active hepatitis C]. (7534222)
1994
48
Serum osteocalcin levels are decreased in patients with acute viral hepatitis. (1907516)
1991
49
Fulminant viral hepatitis. (2116214)
1990
50
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon. (3897068)
1985

Genetic Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Viral Hepatitis

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1alanine4411.4PTMA, IFNA1, SLC17A5, F2, ABCB7, IFNA2
2aspartate4411.3AFP, TMPO, SLC17A5, F2, ABCB7, GPT
3lactate4411.3ABCB7, FAS, FASLG, GGT1, SLC17A5, G6PD
4cisplatin44 49 59 1114.3AFP, IFNA1, FAS, IFNA2, CD40LG, SLC17A5
5ribavirin44 49 1113.3GPT, CD40LG, G6PD, IFNA1, IFNA2, SLC17A5
6n acetylcysteine4411.2F2, FAS, G6PD, CD40LG, GPT, AKR1A1
7ethanol44 49 11 2414.2GGT1, SLC17A5, HFE, FASLG, ABCB7, GPT
8ursodeoxycholic acid44 11 2413.2F2, GGT1, SLC17A5, ABCB7, GPT, CD40LG
9cyclosporin a44 28 5913.2IFNA1, FAS, FASLG, TMPO, GPT, CD40LG
10thyroxine44 2412.2CD40LG, GGT1, SLC17A5, ABCB7, GPT, IFNA2
11iron44 2412.2HFE, IFNA2, ABCB7, GPT, GGT1, SLC17A5
12creatinine4411.2SLC17A5, FAS, GGT1, AFP, F2, ABCB7
13epinephrine44 11 2413.2AFP, F2, G6PD, FASLG, FAS, CD40LG
14ifn-alpha4411.2GPT, CISH, FASLG, FAS, IFNA1, IFNA2
15ascorbic acid44 2412.2CD40LG, HFE, GGT1, IFNA2, G6PD, FASLG
16polyethylene glycol4411.2CD40LG, IFNA1, SLC17A5, IFNA2, G6PD, AFP
17doxorubicin44 49 1113.1AFP, AKR1A1, FASLG, CD40LG, IFNA1, IFNA2
18testosterone44 59 11 2414.1HFE, ABCB7, CD40LG, SLC17A5, GGT1, G6PD
19vitamin b124411.1GPT, SLC17A5, CD40LG, GGT1, AFP, G6PD
20adefovir4411.1SLC17A5, IFNA2, GPT, PTMA, IFNA1
21phenobarbital44 28 1113.1G6PD, AKR1A1, UROD, GPT, SLC17A5, GGT1
22nash4411.0GPT, SLC17A5, AKR1A1, HFE, GGT1
23uric acid44 2412.0ABCB7, HFE, AFP, G6PD
24vitamin-e4411.0SLC17A5, GGT1, GPT, G6PD, IFNA2, ABCB7
25zidovudine44 1112.0TMPO, PTMA, SLC17A5, GPT, IFNA2, IFNA1
26tamoxifen44 49 28 1114.0SLC17A5, FASLG, IFNA1, G6PD, GGT1
27glucose4411.0SLC17A5, CISH, FASLG, IFNA2, TMPO
28entecavir4411.0GPT, IFNA1, PTMA, IFNA2
29lamivudine44 1112.0PTMA, SLC17A5, F2
30serine4411.0FGL2, AFP, SEPSECS, G6PD, AKR1A1, CISH
31agar4411.0AFP, FASLG, FAS, G6PD, PTMA
32acetaminophen44 2 49 11 2415.0SLC17A5, GGT1, GPT
33silymarin4410.9GPT, ABCB7, F2, SLC17A5, GGT1
34mycophenolate mofetil44 49 1112.9GGT1, GPT, IFNA1, SEPSECS, CD40LG
35aminopyrine4410.9GGT1, SLC17A5, F2, GPT
36fibrinogen4410.9AFP, CD40LG, FGL2, GPT, ABCB7, F2
37vitamin a44 11 2412.9IFNA2, FAS, AKR1A1
38estrogen4410.9UROD
39heparin44 28 11 2413.9FAS, FASLG, AFP, ABCB7, CD40LG
40amantadine44 1111.9IFNA2, IFNA1, PTMA, GPT
41gamma globulin4410.9GGT1, IFNA2
42cyclophosphamide44 49 1112.8AFP, FASLG, IFNA1, IFNA2, PTMA, G6PD
43indomethacin44 59 28 1113.8TMPO, AKR1A1, GGT1
44hyaluronic acid44 2411.8CD40LG, GGT1, SLC17A5, F2, FASLG, GPT
45ivig4410.8CD40LG, SEPSECS, GPT
46lipid4410.7GGT1, SLC17A5, ABCB7, GPT, HFE, CISH
47neopterin4410.7CD40LG, IFNA1, GPT, SLC17A5, IFNA2
48thalidomide44 49 59 1113.7CD40LG, FASLG, IFNA2, IFNA1, AFP
49nevirapine44 49 1112.6GGT1, SLC17A5, ABCB7, GPT
505-hydroxytryptophol4410.3GPT, SLC17A5, AKR1A1

GO Terms for genes affiliated with Viral Hepatitis

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16Gene Ontology
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Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.5FASLG, FAS
2inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
3positive regulation of endothelial cell apoptotic processGO:200035310.2CD40LG, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Viral Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet