Viral Hepatitis malady

CDC: "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.²

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis b. An important gene associated with Viral Hepatitis is FGL2 (fibrinogen-like 2), and among its related pathways are Bacterial infections in CF airways and Cell adhesion molecules (CAMs). The compounds ionomycin and glucose have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and kidney, and related mouse phenotypes are embryogenesis and respiratory system.

Disease Ontology: A hepatitis that involves viral infection causing inflammation of the liver.⁶

Wikipedia: Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent...⁴⁴ more...

Aliases & Descriptions:

viral hepatitis 6 8 32 43 unspecified viral hepatitis with hepatic coma 6 viral hepatitis with hepatic coma (disorder) 6 viral hepatitis with hepatic coma 6 hepatitis, viral, animal 43

hepatitis, viral, human 43 animal viral hepatitis 6 human viral hepatitis 6

Diseases related to viral hepatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1004)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	40.6	GPT, IFNA1, SOD2, SLC17A5
2	hepatitis b	36.4	MX1, CD58, FGL2, IL10, MBL2, GPT
3	hepatitis c	33.9	SERPINA1, CISH, MX1, LDLR, CD40LG, GSR
4	autoimmune hepatitis	32.7	SEPSECS, CD14, CD40LG, FAS, GPT, IFNA1
5	alcoholism	32.3	GSR, GPT, AKR1A1, ABCB7, G6PD, TKT
6	liver cirrhosis	30.3	SERPINC1, SERPINA1, SEPSECS, SERPINA3, LEPR, CISH
7	hepatitis a	30.0	PCNA, SERPINC1, SEPSECS, LEP, MX1, B2M
8	pure red-cell aplasia	30.0	CD40LG, IL2, IFNA1, F2, ALB, HP
9	hepatitis e	29.5	CD99, CD40LG, GPT, IFNA1, IFNA2, IFNG
10	hepatocellular cancer	29.0	BAX, F2, TNFRSF10B, TERT, TGFB1, SOD1
11	pancytopenia	28.5	IFNG, F3, HP, THPO, CSF3, CP
12	multiple sclerosis	28.3	CD58, CD14, IL1A, IL4R, IFNG, ICAM1
13	alcohol abuse	28.2	UROD, LCAT, B2M, GSR, GPT, IGHE
14	typhoid fever	27.9	IL1A, GPT, IFNG, F2, HLA-DQB1, HLA-DRB1
15	malaria	27.4	CISH, CD40LG, IL10, IL1A, IL4, IL4R
16	intrahepatic cholangiocarcinoma	27.1	SERPINA3, MUC6, BAX, CFLAR, CDKN2A, IL6
17	jaundice	25.5	UGT1A, LCAT, LAP3, CD14, ITGAL, GSR
18	inflammatory bowel disease	25.0	SERPINA1, SERPINA3, BGLAP, MPO, CDH2, CD14
19	iron overload	24.8	UROD, B2M, INS, GPT, IFNA1, F5
20	nonalcoholic steatohepatitis	24.7	PCNA, LEP, LEPR, MPO, INS, GSR
21	vitiligo	24.2	BAX, MPO, GSR, IL10, IL4, IL6
22	thrombocytopenia	23.5	SERPINC1, MYB, CDKN1A, CD40LG, ITGAL, INS
23	cholangiocarcinoma	23.5	PCNA, SERPINA1, SERPINA3, UROD, MUC6, BAX
24	schistosomiasis	23.3	SERPINC1, LCAT, CDKN1A, CDKN2A, CD40LG, INS
25	lichen planus	22.2	PCNA, MX1, BAX, CD58, CD14, CDKN2A
26	blindness	20.3	SERPINC1, BGLAP, LEP, B2M, MPO, CDKN1A
27	purpura	20.3	SERPINC1, SEPSECS, LEP, MX1, CFLAR, MPO
28	insulin resistance	20.0	SGK1, SERPINA3, BGLAP, LEP, LEPR, CISH
29	hepatocellular carcinoma	19.8	PCNA, SERPINC1, SERPINA1, SEPSECS, SERPINA3, CLIC1
30	fibrosis	19.1	SGK1, PCNA, SERPINC1, SERPINA1, SEPSECS, SERPINA3
31	thrombosis	18.8	PCNA, SERPINC1, SERPINA1, SERPINA3, BGLAP, LEP
32	carcinoma	18.3	PCNA, SERPINC1, SERPINA1, SEPSECS, SERPINA3, MYB
33	anemia	18.1	SGK1, PCNA, SERPINC1, MYB, CLIC1, UROD
34	cholesterol	17.2	SGK1, SERPINC1, SERPINA1, SERPINA3, MYB, BGLAP
35	diabetes mellitus	17.0	SGK1, SERPINC1, SERPINA1, SERPINA3, CLIC1, BGLAP
36	thyroiditis	16.3	PCNA, SERPINC1, SERPINA1, BGLAP, LEP, LEPR
37	peritonitis	16.0	SGK1, PCNA, SERPINC1, BGLAP, LEP, LEPR
38	bilirubin metabolic disorder	14.2	UGT1A, GPT, F2, ALB, HP, G6PD
39	hepatic tuberculosis	14.1	SERPINA1, F2, ALB, ALPP, GGT1
40	hepatitis d	14.1	CD40LG, GPT, IFNA1, IFNA2, F2, TNF
41	obstructive jaundice	14.0	LCAT, GPT, ALPP, AKR1A1, TTR, SLC17A5
42	acute liver failure	14.0	FST, GPT, F2, ALB, THPO, SLC17A5
43	porphyria cutanea tarda	14.0	SEPSECS, UROD, IFNA1, ALB, HLA-A, HLA-B
44	crigler-najjar syndrome	14.0	F2, ALB, ALPP, CYP3A4, CYP2A6, G6PD
45	cavernous hemangioma of face	14.0	F8, F2, KRIT1, KRT18, KRT19, ACTC1
46	chondrodysplasia punctata 1, x-linked	14.0	BGLAP, F8, F2, AFP
47	acute myocarditis	14.0	APOH, FASLG, FAS, TXN, ABCB7
48	choledocholithiasis	13.9	GPT, ALB, ALPP, SLC17A5, GGT1
49	substance abuse	13.9	GPT, CYP3A4, ABCB7, TF, SLC17A5, ADH1B
50	syphilis	13.9	B2M, CD40LG, FN1, APOH, IGHE, F2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to viral hepatitis:

²²

MGI Mouse Phenotypes related to viral hepatitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	10.4	G6PD, ABCB7, KRT19, KRT18, KRT8, KRIT1
2	respiratory system phenotype	MP:0005388	10.3	ADA, CD14, FST, LEPR
3	endocrine/exocrine gland phenotype	MP:0005379	10.1	LDLR, CD40LG, IL2, IL2RB, FASLG, IFNG
4	liver/biliary system phenotype	MP:0005370	9.0	EPO, ADA, SERPINC1, MYB, UROD, LCAT
5	integument phenotype	MP:0010771	9.0	MYB, LEPR, LDLR, FST, CDKN1A, IL2RB
6	renal/urinary system phenotype	MP:0005367	8.9	SGK1, LEPR, LCAT, BAX, CDKN1A, INS
7	reproductive system phenotype	MP:0005389	8.7	KRT8, KRT19, TSHR, TLR3, TLR4, TGFB1
8	other phenotype	MP:0005395	8.7	SOD2, TLR2, ABCB7, NOS2, TNFRSF1A, IL2
9	hematopoietic system phenotype	MP:0005397	8.6	HGF, EPO, ADA, ADAM8, HLA-C, HLA-DQA1
10	immune system phenotype	MP:0005387	8.5	IFNB1, IFNG, F8, F2, AKR1A1, HLA-C
11	normal phenotype	MP:0002873	8.2	ELANE, CTGF, TERT, HLA-DQB1, ALPP, HFE
12	skeleton phenotype	MP:0005390	7.9	CD14, ADAM8, ADA, STAT1, TGFA, CDKN2A
13	adipose tissue phenotype	MP:0005375	7.8	TLR2, TLR4, TKT, TGFA, TGFB1, SOD2
14	digestive/alimentary phenotype	MP:0005381	7.3	CTGF, NOS2, KRT8, KRT19, EDN1, HFE
15	growth/size phenotype	MP:0005378	7.0	IL2RB, IL4R, IL6, FAS, GPX1, GPX2
16	nervous system phenotype	MP:0003631	7.0	TSHR, TYMP, G6PD, ABCB7, EDN1, KRT19
17	mortality/aging	MP:0010768	6.6	LDLR, CFLAR, FZD9, FST, CDKN1A, CDH2
18	tumorigenesis	MP:0002006	6.4	LEP, LEPR, B2M, CDKN1A, CDKN2A, ITGAL
19	vision/eye phenotype	MP:0005391	5.7	TTR, KRIT1, NOS2, CTGF, TNFRSF1A, TNF
20	muscle phenotype	MP:0005369	4.9	TLR2, ACTC1, EDN1, NOS2, TNFRSF1A, TNF
21	cardiovascular system phenotype	MP:0005385	4.4	IFNG, ABCB7, ACTC1, G6PD, TLR2, TLR3
22	cellular phenotype	MP:0005384	3.8	ADAM8, ADA, ADIPOQ, HGF, EPO, CP
23	homeostasis/metabolism phenotype	MP:0005376	3.5	STAT1, SOD1, SOD2, SLPI, SLC17A5, CP

Articles related to viral hepatitis:

(show top 50)    (show all 314)

id	Title	Authors	Year	Affiliating Genes
1	IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the de velopment of HCC. (21146242)	Fabris C.... Toniutto P.	2011	IL28B
2	Host mechanisms in viral hepatitis. (20460887)	Lang K.S.	2010	IL7
3	Bicyclol: a novel drug for treating chronic viral hepatitis B and C. (19149648)	Liu G.T.	2009	SLC17A5
4	Role of a host in spontaneous recovery from viral hepatitis C: genetic predetermined factors (19172906)	Isaguliants M.G.... Ozeretskovskaia N.N.	2008	IFNG
5	The expression and function of NKG2D molecule on intrahepatic CD8+ T cells in chronic viral hepatitis. (19087227)	Kennedy P.T.... Bertoletti A.	2008	KLRK1
6	Chronic viral hepatitis and iron affect the plasma levels of LIGHT--a new member of the TNF superfamily in uraemic haemodialyzed patients. (17827030)	Pawlak K.... Pawlak D.	2007	TNFSF14, DARC
7	Prevalence and associated factors of viral hepatitis and transferrin elevations in 5036 patients admitted to the emergency room of a Swiss university hospital: cross-sectional study. (17280611)	Russmann S.... Zimmermann H.	2007	TF
8	An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study. (17540037)	Manolakopoulos S.... Theocharis S.	2007	LEP, LSL
9	Experiences in antiviral treatment of chronic viral hepatitis B and C in Hungary (1998-2004) (17468063)	PA!r A.... Szalay F.	2007	IFNA2
10	LIGHT--a new member of the TNF superfamily in the plasma, dialysate and urine of uremic patients; the impact of residual diuresis and presence of viral hepatitis. (17826757)	Pawlak K.... Mysliwiec M.	2007	TNFSF14
11	Influence of acetaminophen at therapeutic doses on surrogate markers of severity of acute viral hepatitis. (16801900)	Yaghi C.... Sayegh R.	2006	F2, F5
12	Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases. (16226105)	Saitou Y.... Nakano T.	2005	TNFRSF10B, TNFSF10, TNFRSF10A
13	Influence of plasma exchange on serum cytokines in severe viral hepatitis patients (12857473)	He J.... Chen G.C.	2003	IL4
14	The effect of recombinant interferon alpha treatment on hearing thresholds in patients with chronic viral hepatitis B. (12589849)	GAPrA1r K.... Ozcan C.	2003	IFNA1
15	Impact of interferon-alpha therapy on the serum level of alpha-fetoprotein in patients with chronic viral hepatitis. (14737946)	Kasztelan-SzczerbiA8ska B.... SzczerbiA8ski M.	2003	AFP, IFNA1
16	Viral hepatitis in patients infected with human immun odeficiency virus. (14533986)	Pavan M.H.... GonAsales JA_nior F.L.	2003	GPT
17	Accurate prediction of fulminant hepatic failure in severe acute viral hepatitis: multicenter study. (12501858)	Yoshiba M.... Shibuya A.	2002	F2
18	Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. (11355694)	Kim J.W.... Choe I.S.	2001	NINJ1
19	Screening for cancer in viral hepatitis. (11218910)	Colombo M.	2001	AFP
20	Decreased serum aminotransferase activity in patients with chronic renal failure: impact on the detection of viral hepatitis. (11684554)	Fabrizi F.... Locatelli F.	2001	GPT, SLC17A5
21	Disorders of hepatic sinusoids and perisinusoidal space in chronic viral hepatitis B and its relationship to hepatic fibrosis (10951618)	Liu J.... Ma Y.	2000	FN1, ACTC1
22	Depression during interferon therapy for chronic viral hepatitis: early identification of patients at risk by means of a computerized test. (10833092)	Scalori A.... Mancia G.	2000	IFNA1
23	Thioredoxin levels in the sera of untreated viral hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid. (11213474)	Nakashima T.... Yodoi J.	2000	TXN
24	Thrombopoietin levels in serum and liver tissue in patients with chronic viral hepatitis and hepatocellular carcinoma. (11787473)	Okubo M.... Kawasaki H.	2000	THPO
25	Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP). (10385667)	CarreA+o V.... Quiroga J.A.	1999	IFNA1
26	Interferon-ribavirin for chronic hepatitis C with and without cirrhosis: analysis of individual patient data of six controlled trials. Eurohep Study Group for Viral Hepatitis. (10419923)	Schalm S.W.... Brouwer J.T.	1999	IFNA1
27	Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients. (9681157)	Hung K.Y.... Chen W.Y.	1998	SLC17A5
28	Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. European Concerted Action on Viral Hepatitis (EUROHEP). (9362381)	Fattovich G.... Schalm S.W.	1997	IFNA1
29	Current therapeutic trends in therapy for chronic viral hepatitis. (9407357)	Liaw Y.F.	1997	IFNA1, PTMA
30	The treatment of chronic viral hepatitis with recombinant alpha-2 interferon: meta analysis and clinical contribution (9470304)	Raffa S.... Grassi M.	1997	IFNA2, IFNA1
31	Is carbohydrate-deficient transferrin a specific marker for alcohol abuse? A study in patients with chronic viral hepatitis. (9347098)	Perret R.... Gonvers J.J.	1997	TF
32	Host factors in chronic viral hepatitis. (9408970)	Thursz M.R.... Thomas H.C.	1997	TNF, MBL2
33	Relation between treatment efficacy and cumulative dose of alpha interferon in chronic hepatitis B. European Concerted Action on Viral Hepatitis (Eurohep). (9007705)	Krogsgaard K.... Ring-Larsen H.	1996	IFNA1
34	Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. (8942737)	Strassburg C.P.... Manns M.P.	1996	UGT1A
35	Do serum ALAT values reflect the inflammatory activity in the liver of patients with chronic viral hepatitis? (8740843)	Cahen D.L.... Chamuleau R.A.	1996	GPT
36	Chronic viral hepatitis in childhood. (8864029)	Bortolotti F.	1996	IFNA1
37	Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis. (8729757)	Lopes E.P.... Ferraz M.L.	1995	IFNA1
38	Evaluation of the special therapies in fulminant viral hepatitis--a multi-institution study (7861629)	Takahashi Y.	1995	F2
39	The interferon reaction of the leukocytes and the natural killer activity in patients with acute viral hepatitis B undergoing interferon treatment (7998397)	Golban T.D.... Antonenko S.M.	1994	IFNA2
40	Sex hormones and sex hormone-binding globulin in males with chronic viral hepatitis during recombinant interferon-alpha 2b therapy. (8366286)	Barreca T.... Rolandi E.	1993	IFNA2
41	Use of interferon in the treatment of chronic viral hepatitis. (8049886)	Gibas A.L.	1993	GPT
42	The interferon-alpha 2b gene in Japanese patients with chronic viral hepatitis who developed antibodies after treatment with recombinant interferon-alpha 2a. (1515568)	Hosoi H.... Yamanaka M.	1992	IFNA2, IFNA1
43	Hepatocyte stimulatory peptide and its clinical significance in viral hepatitis (1306456)	Zhou W.P.... Ren H.	1992	F2
44	The evaluation of acute viral hepatitis seen in a regional hospital (1340678)	PAcrez C.A.... OrtA-z P.O.	1992	F2
45	The tocopherol acetate and splenin correction of the immunological disorders in patients with viral hepatitis B (1441392)	Frolov V.M.... PshenichnyA- I.I.a.	1992	TMPO
46	Role of prostaglandin E2 on defective interferon-gamm a production during type B acute viral hepatitis. (1907761)	Baraldini M.... Gasbarrini G.	1991	IFNG
47	Changes in plasma high density lipoprotein cholesterol and phospholipid in acute viral hepatitis and cholestatic jaundice. (1995758)	Ahaneku J.E.... Taylor G.O.	1991	ALPP
48	The comparative characteristics of the indices of lymphocyte and neutrophil functional activity in patients with HIV infection and chronic viral hepatitis B (1679592)	Gabrilovich D.I.... PokrovskiA- V.V.	1991	CDKN3
49	Recurrences of viral hepatitis A (2077829)	Jelic O.... Jelic D.	1990	GPT
50	The functioning of the glutathione system in patients with acute viral hepatitis B (2336629)	Nikitin E.V.... Pak S.G.	1990	GPX1, GPX2

Genes related to viral hepatitis according to GeneCards:

(show top 50)    (show all 153)

id	Symbol	Description	Score	GeneCards Section Context
1	FGL2	fibrinogen-like 2	11.0	Publications
2	PTMA	prothymosin, alpha	11.0	Publications
3	UROD	uroporphyrinogen decarboxylase	11.0	Publications
4	IFNA1	interferon, alpha 1	11.0	Publications
5	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
6	IFNA2	interferon, alpha 2	11.0	Publications
7	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
8	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	11.0	Publications
9	CISH	cytokine inducible SH2-containing protein	11.0
10	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
11	F2	coagulation factor II (thrombin)	11.0	Publications
12	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
13	KRT8	keratin 8	11.0	Publications
14	AFP	alpha-fetoprotein	11.0	Publications
15	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
16	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
17	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0
18	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
19	GGT1	gamma-glutamyltransferase 1	11.0	Publications
20	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
21	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
22	TMPO	thymopoietin	11.0	Publications
23	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
24	KRIT1	KRIT1, ankyrin repeat containing	11.0	Publications
25	F10	coagulation factor X	11.0	Publications
26	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0
27	FN1	fibronectin 1	11.0	Publications
28	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0
29	CTGF	connective tissue growth factor	11.0
30	RSF1	remodeling and spacing factor 1	11.0
31	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
32	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
33	TSHR	thyroid stimulating hormone receptor	11.0	Publications
34	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
35	CD14	CD14 molecule	11.0	Publications
36	KRT18	keratin 18	11.0
37	STAT1	signal transducer and activator of transcription 1, 91kDa	11.0
38	IFNB1	interferon, beta 1, fibroblast	11.0
39	LCAT	lecithin-cholesterol acyltransferase	11.0
40	TLR2	toll-like receptor 2	11.0	Publications
41	HFE	hemochromatosis	11.0	Publications
42	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0
43	F8	coagulation factor VIII, procoagulant component	11.0
44	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
45	DNAH8	dynein, axonemal, heavy chain 8	11.0
46	ABHD14A	abhydrolase domain containing 14A	11.0
47	IFN1@	interferon, type 1, cluster	11.0	Publications
48	GPX2	glutathione peroxidase 2 (gastrointestinal)	11.0	Publications
49	FZD9	frizzled family receptor 9	11.0	Publications
50	NINJ1	ninjurin 1	11.0	Publications

Pathways related to viral hepatitis according to GeneDecks:

(show top 50)    (show all 103)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.8	TLR2
2	Cell adhesion molecules (CAMs)20	10.5	CD58, CD99, ITGA4, ITGAL
3	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.5	TLR8, IFNB1, TLR7, CCL20, IL6, CD14
4	Toll-like receptor signaling pathway20	10.4	TLR8, TLR9, STAT1, CD14, IL6, TLR7
5	Immune response_TLR signaling pathways41	10.3	CD14, FN1, IL4, IL6, CCL20, IFNB1
6	Graft-versus-host disease20	10.1	HLA-DQA1, HLA-C, HLA-B, HLA-A, FASLG, IL2
7	all-trans-Retinoic Acid Mediated Apoptosis36	10.0	TNFSF10, TNFRSF10B, TNFRSF10A, IFNB1, IFNA2, CFLAR
8	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	FAS, IL10, IL2, IL2RB, FASLG, TNF
9	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	TGFB1, IFNG, TLR9, TLR7, TLR2, IL4
10	Jak-STAT signaling pathway20	9.8	IFNB1, IFNA2, IFNA1, IL7, IL4, IL2RB
11	Natural killer cell mediated cytotoxicity20	9.8	HLA-C, HLA-B, TNFRSF10A, TNFRSF10B, ICAM1, IFNG
12	Measles20	9.8	IL4, IL6, FASLG, FAS, IFNA1, IFNA2
13	Influenza A20	9.8	TLR7, MX1, IL1A, IL6, FASLG, IFNA1
14	NF-KappaB (p50-p65) Pathway36	9.7	TLR4, TGFA, THPO, TLR9, TLR8, TLR7
15	Hematopoietic cell lineage20	9.7	EPO, THPO, ITGA4, TNF, CD14, IL1A
16	NF-KappaB Family Pathway36	9.7	TLR2, TNFRSF1A, HGF, TNF, IL6, IL1A
17	Apoptosis and survival Apoptotic TNF-family pathways10	9.7	TNFRSF10A, TNF, FAS, FASLG, BAX, TNFSF14
18	Rheumatoid arthritis20	9.6	ITGAL, IL1A, HLA-DQB1, IL6, CCL20, IFNG
19	Akt Signaling36	9.6	HGF, THPO, GFER, CTGF, TNFRSF1A, TNFRSF10A
20	Autoimmune thyroid disease20	9.6	FAS, FASLG, IL4, IL2, IL10, CD40LG
21	THC Differentiation Pathway36	9.6	IL2, IL10, TNF, TNFRSF1A, HLA-DRB1, HLA-DQB1
22	Th1 Differentiation37	9.5	IL10, TLR7, TLR9, IL2, IFNG, TNF
23	Cytokine Network36	9.5	IFNA2, IFNB1, IFNG, IFNA1, IL6, IL4
24	Leishmaniasis20	9.4	STAT1, TGFB1, TLR4, TLR2, NOS2, TNF
25	Intestinal immune network for IgA production20	9.4	CD40LG, ITGA4, IL10, IL2, IL4, IL6
26	PGC1Alpha Pathway36	9.4	BAX, IL1A, IL2RB, IL4, IL4R, IL7
27	Toxoplasmosis20	9.4	LDLR, CD40LG, HLA-DQA1, STAT1, TGFB1, TLR4
28	Apoptosis and survival_Apoptotic TNF-family pathways41	9.4	TNFRSF1A, FAS, TNFSF14, BAX, FASLG, TNF
29	Allograft rejection20	9.2	CD40LG, FASLG, IL10, TNF, HLA-DRB1, HLA-DQB1
30	Chagas disease (American trypanosomiasis)20	9.2	TNFRSF1A, IFNB1, FAS, FASLG, IL6, IL2
31	Malaria20	9.2	ITGAL, IL6, IL10, CD40LG, HGF, CSF3
32	Type I diabetes mellitus20	9.1	INS, IL1A, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
33	Colorectal Cancer Metastasis36	9.0	TNF, FZD9, TNFRSF1A, TLR2, TLR3, IL6
34	Tuberculosis20	8.8	BAX, CD14, IL10, TNFRSF1A, NOS2, TLR2
35	TGF-Beta Pathway36	8.7	IL7, IL6, IL4R, IL4, IL2RB, IL2
36	JAK-STAT Pathway36	8.6	TNFSF10, IFNA1, IFNA2, IFNB1, IFNG, F2
37	Rho Family GTPases36	8.5	IL4, TNFSF10, IL7, CCL20, BAX, ITGAL
38	Tec Kinases Signaling36	8.5	CCL20, THPO, TGFA, TGFB1, STAT1, HGF
39	MAPK Family Pathway36	8.5	IL4R, IL7, BAX, CTGF, HGF, TGFB1
40	Cytokine-cytokine receptor interaction20	8.5	IL10, CD40LG, LEPR, LEP, IL1A, IL2
41	Cellular Apoptosis Pathway36	8.4	TGFA, CTGF, GFER, TNFSF10, TNFRSF1A, THPO
42	MIF Mediated Glucocorticoid Regulation36	8.4	IL6, TLR4, CSF3, HGF, TNFSF14, TNFSF10
43	MIF Regulation of Innate Immune Cells36	8.4	IL7, TNF, IL10, HGF, CSF3, TLR4
44	p38 Signaling36	8.3	HGF, THPO, GFER, CTGF, TGFA, TGFB1
45	PEDF Induced Signaling36	8.3	TNFSF14, TNFSF10, TNF, CCL20, IL7, IL6
46	Molecular Mechanisms of Cancer36	8.3	IL4R, BAX, CFLAR, FZD9, TNFRSF10B, TNFSF10
47	Antioxidant Action of Vitamin-C36	8.3	CCL20, TNF, TNFRSF10A, TNFRSF10B, CSF3, IL7
48	Glucocorticoid Receptor Signaling36	8.3	CDKN1A, IL4R, IL4, IL2RB, IL6, IL2
49	PAK Pathway36	8.1	HGF, CSF3, TGFB1, IL4, IL1A, IL10
50	STAT3 Pathway36	7.9	CSF3, HGF, IL7, IL6, IL4R, IL4

Compounds related to viral hepatitis according to GeneDecks:

(show top 50)    (show all 516)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.9	SERPINA3, IL7, TNFRSF1A, KRIT1, TSHR
2	glucose32	10.7	CISH, LAP3, CFLAR, FUCA1, FST, IFNA2
3	ivig32	10.6	SEPSECS, FASLG, IFNB1, F8, CRP, TG
4	sialic acid32	10.6	SERPINA3, FUCA1, CDH2, MBL2, IFNB1, F8
5	polyethylene glycol32	10.5	SERPINC1, MPO, FN1, IFNA2, F8, ALPP
6	phosphatidylserine32 9 9	12.4	CD99, CD14, MBL2, F5, F2, F10
7	agar32	10.2	FST, CDKN2A, CD40LG, FN1, IL7, TXN
8	guanidine hydrochloride32	10.1	SERPINA3, BGLAP, FN1, GSR, F3, ALPP
9	carbohydrates32	10.1	LDLR, CD58, CD14, MBL2, F10, AKR1A1
10	pge132	10.1	LCAT, B2M, IL1A, APOH, GPT, IGHE
11	acetaminophen32 34 9 18 9	13.8	PCNA, UGT1A, B2M, GPT, IGHE, IFNB1
12	acetaldehyde32 18	10.8	LCAT, FN1, IL10, IL4, CAT, AKR1A1
13	rituximab32 34 9 9	12.7	CFLAR, CD40LG, IL10, IL2, FASLG, F8
14	biotin32 9 18 9	12.7	PCNA, B2M, CDKN2A, CD40LG, CDKN3, FN1
15	latex32	9.6	CDH2, CD14, ITGAL, FN1, APOH, MBL2
16	malondialdehyde32	9.5	MPO, GSR, APOH, GPT, GPX1, F5
17	p00232	9.4	LEP, CFLAR, CD14, APOH, GPT, IFNB1
18	mitomycin c32	9.3	PCNA, CD58, GSR, FASLG, FAS, TYMP
19	alpha tocopherol32	9.1	BGLAP, LEP, LDLR, LCAT, CDKN3, ITGAL
20	n acetylcysteine32	9.0	PCNA, SERPINC1, CDKN1A, CDKN2A, IL2RB, GPT
21	progesterone32 42 9 18 9	12.9	PCNA, SERPINA3, MYB, LEPR, MUC6, FST
22	zidovudine32 9 9	10.7	UGT1A, B2M, IL10, IL2, GPT, IFNA1
23	mycophenolate mofetil32 9 9	10.7	SEPSECS, UGT1A, CD40LG, IL10, IL2, IL2RB
24	superoxide32 18	9.7	SERPINA3, LEPR, MPO, CD14, ITGAL, GSR
25	nifedipine32 9 9	10.7	BGLAP, LEP, UGT1A, LDLR, B2M, IL1A
26	okt332	8.6	CD40LG, IL10, IL2, IL2RB, IL4, IL6
27	polymyxin b32	8.6	LDLR, CD14, IL10, IL1A, IL4, IL6
28	aspirin32 34 18	10.4	PCNA, SERPINC1, LDLR, CD40LG, ITGAL, FN1
29	adenylate32	8.4	SGK1, SERPINC1, MYB, LDLR, FST, CDH2
30	wortmannin32 42	9.3	SGK1, LEP, BAX, CFLAR, CDKN1A, CD14
31	5-aza-2deoxycytidine32	8.3	PCNA, CISH, CFLAR, FST, CDKN1A, CDH2
32	herbimycin a32 42	9.1	CD14, CD40LG, CDKN3, FN1, IL1A, IL2
33	azathioprine32 34 9 9	11.1	PCNA, BGLAP, CDKN2A, ITGAL, IL10, IL2
34	sb 20358032 42	9.1	BGLAP, CDKN1A, IL6, IFNB1, IFNG, ALPP
35	tamoxifen32 34 9 9	11.0	PCNA, SERPINC1, BGLAP, LEP, UGT1A, LDLR
36	rantes32	8.0	MX1, CD58, CD14, CD40LG, ITGA4, ITGAL
37	adriamycin32	8.0	BAX, B2M, CFLAR, CDKN1A, CDKN2A, FN1
38	prednisolone32 9 9	10.0	BGLAP, MPO, CD14, CDKN3, ITGAL, IL10
39	butyrate32	7.9	PCNA, MYB, LEP, LCAT, BAX, LAP3
40	nitric oxide32 9 18 9	10.8	SERPINA1, CISH, MPO, FST, CDKN2A, ITGA4
41	vitamin d32	7.6	BGLAP, LEPR, LDLR, B2M, CDKN1A, CD14
42	estrogen32	7.6	PCNA, SERPINC1, SERPINA1, SERPINA3, BGLAP, UROD
43	tacrolimus32 34 9 9	10.4	PCNA, CDKN3, ITGA4, ITGAL, FN1, INS
44	lipid32	7.2	SGK1, SERPINA1, SERPINA3, MYB, CLIC1, LEP
45	5fluorouracil32	7.0	PCNA, MUC6, BAX, CFLAR, MPO, CDKN1A
46	prostacyclin32	6.9	SERPINC1, LEP, LDLR, FN1, IL10, IL1A
47	lactate32	6.5	PCNA, LAP3, B2M, FUCA1, MPO, FST
48	actinomycin d32	5.3	SGK1, MYB, UGT1A, LDLR, BAX, CFLAR
49	genistein32 9 18 9	8.3	PCNA, UGT1A, LDLR, BAX, B2M, FST
50	retinoic acid32 42 18	6.7	PCNA, SERPINA3, MYB, BGLAP, UGT1A, LDLR

Cellular components related to viral hepatitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome membrane	GO:036020	10.4	TLR9, TLR8, TLR7, TLR3
2	endosome membrane	GO:010008	10.0	TLR9, TLR8, TLR7, TLR4, TLR3, HLA-DQB1
3	platelet alpha granule lumen	GO:031093	10.0	HGF, TGFB1, ALB, F5, F8, FN1
4	ER to Golgi transport vesicle membrane	GO:012507	10.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
5	external side of plasma membrane	GO:009897	9.7	IFNG, ICAM1, HLA-DRB1, TNF, TLR2, TLR4
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
7	cell surface	GO:009986	9.6	ELANE, TLR2, TLR3, THBD, TGFA, TGFB1
8	integral to plasma membrane	GO:005887	9.4	TNFRSF1A, TNFSF10, PTPRN, HFE, TSHR, TLR2
9	plasma membrane	GO:005886	8.2	CTGF, DARC, TNFSF14, TNFRSF1A, TNFRSF10B, TNF
10	extracellular region	GO:005576	5.8	GAST, SERPINC1, IL2, IL4R, IL6, IL7
11	extracellular space	GO:005615	4.8	SERPINC1, IL28B, IL4, IL6, IL7, APOH

Biological processes related to viral hepatitis according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to mechanical stimulus	GO:071260	10.7	TLR8, TLR7, TLR4, TLR3, TNFSF14, TNFRSF1A
2	positive regulation of interferon-beta biosynthetic process	GO:045359	10.6	TLR9, TLR8, TLR7, TLR4, TLR3
3	I-kappaB phosphorylation	GO:007252	10.6	TLR9, TLR7, TLR4, TLR3, TLR2
4	positive regulation of NF-kappaB import into nucleus	GO:042346	10.6	TLR9, TLR7, TLR4, TLR3, TLR2, TNF
5	positive regulation of interferon-alpha biosynthetic process	GO:045356	10.5	TLR9, TLR8, TLR7, TLR3
6	positive regulation of tumor necrosis factor production	GO:032760	10.5	TLR9, TLR4, TLR3, TLR2, TNFRSF1A, IFNG
7	positive regulation of chemokine production	GO:032722	10.4	TLR9, TLR7, TLR4, TLR3, TLR2, TNF
8	positive regulation of interleukin-8 biosynthetic process	GO:045416	10.4	ELANE, TLR4, TLR7, TLR8, TNF
9	induction of apoptosis via death domain receptors	GO:008625	10.4	FASLG, FAS, TNF, TNFRSF10A, TNFRSF10B
10	positive regulation of interleukin-12 production	GO:032735	10.4	TLR9, TLR4, TLR3, TLR2, IFNG, CD40LG
11	positive regulation of interleukin-8 production	GO:032757	10.3	ADIPOQ, TLR9, TLR7, TLR4, TLR3, TLR2
12	positive regulation of interleukin-6 production	GO:032755	10.3	TLR9, TLR7, TLR4, TLR3, TLR2, TNF
13	positive regulation of inflammatory response	GO:050729	10.2	TLR9, TLR7, TLR4, TLR3, TLR2, TNFRSF1A
14	platelet degranulation	GO:002576	10.1	HGF, SOD1, TF, TGFB1, ALB, F5
15	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.0	ADIPOQ, TLR9, TLR4, TLR3, TNFSF10, TNFRSF1A
16	positive regulation of MHC class II biosynthetic process	GO:045348	10.0	TLR4, IFNG, IL4, IL10, CD40LG
17	negative regulation of growth of symbiont in host	GO:044130	9.9	TLR2, ELANE, TNF, IFNG, MBL2, IL10
18	platelet activation	GO:030168	9.9	HGF, SOD1, TF, TGFB1, THPO, ALB
19	negative regulation of interleukin-6 production	GO:032715	9.9	TLR9, TLR4, TNFRSF1A, TNF, IL10
20	acute-phase response	GO:006953	9.9	CRP, F2, F8, MBL2, IL6, INS
21	interferon-gamma-mediated signaling pathway	GO:060333	9.8	STAT1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
22	inflammatory response	GO:006954	9.8	DARC, CRP, TLR2, TLR3, TLR7, TLR8
23	regulation of immune response	GO:050776	9.7	HLA-C, HLA-B, HLA-A, ICAM1, IL4, ITGAL
24	defense response to bacterium	GO:042742	9.7	TLR9, TLR4, TLR3, NOS2, TNFRSF1A, IFNG
25	induction of apoptosis	GO:006917	9.6	TNFRSF10A, TNFSF10, TNFSF14, TLR2, TGFB1, STAT1
26	positive regulation of cytokine secretion	GO:050715	9.6	TLR2, TNF, IL1A, IL10, INS, CD14
27	blood coagulation	GO:007596	9.6	F2, ALB, F10, NOS2, THBD, THPO
28	positive regulation of B cell proliferation	GO:030890	9.6	ADA, CDKN1A, CD40LG, IL2, IL4, IL7
29	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.5	ADAM8, TGFB1, TLR9, TLR4, TLR3, TLR2
30	response to lipopolysaccharide	GO:032496	9.4	EPO, THPO, THBD, TLR4, ELANE, EDN1
31	virus-host interaction	GO:019048	9.4	KRT8, KRT7, KRT18, KRT19, TGFB1, STAT1
32	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.3	TNF, TNFRSF10A, TNFRSF10B, TNFSF10, F3, IFNB1
33	response to ethanol	GO:045471	9.3	ADIPOQ, SOD1, TLR4, ACTC1, TNFRSF1A, ICAM1
34	positive regulation of protein kinase B signaling cascade	GO:051897	9.3	ADAM8, TGFB1, TNF, F10, F3, GPX1
35	cytokine-mediated signaling pathway	GO:019221	9.3	MX1, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNFRSF1A
36	immune response	GO:006955	9.1	HLA-DQB1, HLA-DRB1, TNFSF10, TNFSF14, HFE, TLR2
37	anti-apoptosis	GO:006916	9.0	TNF, TERT, TGFA, SOD1, HGF, EPO
38	positive regulation of nitric oxide biosynthetic process	GO:045429	8.9	TLR4, TLR2, EDN1, TNF, ICAM1, IFNG
39	response to hypoxia	GO:001666	8.6	NOS2, EDN1, TLR4, TGFB1, ADA, ADIPOQ
40	positive regulation of cell proliferation	GO:008284	8.2	EPO, CSF3, TGFB1, THPO, TSHR, EDN1
41	response to drug	GO:042493	7.9	TNFRSF11B, EDN1, ACTC1, TGFA, TGFB1, SOD1

Molecular functions related to viral hepatitis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	10.2	STAT1, TNFSF14, TNFSF10, TNF, FASLG, CD40LG
2	receptor activity	GO:004872	9.9	TLR8, TLR4, TLR3, TLR2, DARC, TNFRSF11B
3	protease binding	GO:002020	9.2	ELANE, TNFRSF1A, TNF, F3, INS, SERPINA1
4	growth factor activity	GO:008083	8.9	TYMP, THPO, TGFA, TGFB1, CSF3, HGF
5	hormone activity	GO:005179	8.4	GAST, EPO, ADIPOQ, TG, THPO, TTR
6	cytokine activity	GO:005125	7.6	IFNA2, IFNB1, IFNG, TNF, TNFRSF11B, TNFSF10
7	protein binding	GO:005515	4.3	CRP, TSHR, TLR2, TLR4, THBD, TGFA