MCID: VRL010
MIFTS: 64

Viral Hepatitis malady

Infectious diseases, Gastrointestinal diseases, Rare diseases, Liver diseases, Immune diseases categories
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Summaries for Viral Hepatitis

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CDC:3 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards based summary: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis a and hepatitis b. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are African trypanosomiasis and Death Receptor Signalling. The compounds hepaplastin and adefovir have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:65 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 25ICD10
See all sources

Viral Hepatitis, Aliases & Descriptions:

Name: Viral Hepatitis 8 10 44 62
Unspecified Viral Hepatitis with Hepatic Coma 8 62
Viral Hepatitis with Hepatic Coma 8 62
Hepatitis, Viral, Animal 62
 
Hepatitis, Viral, Human 62
Animal Viral Hepatitis 8
Human Viral Hepatitis 8


Classifications:



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Disease Ontology8 DOID:1884
MeSH34 D006524

Related Diseases for Viral Hepatitis

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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis
Hepatitis B Hepatitis D
Hepatitis a Hepatitis E
viral hepatitis Hepatitis C Virus
Susceptibility to Hepatitis Due to Voriconazole Treatment Susceptibility to Hepatitis Due to Flucloxacilline Treatment

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a32.2F2
2hepatitis b31.2ABCB7, GPT, AFP, IFNA2, SLC17A5, F2
3hepatitis e31.1GPT, CD40LG
4hepatitis d30.9IFNA2, GPT
5cholecystitis30.8GPT
6alcohol abuse30.7GPT, SLC17A5, ABCB7
7fatty liver disease30.7ABCB7, GPT, SLC17A5
8acute pancreatitis30.6SLC17A5, GPT, ABCB7
9hepatitis30.6SLC17A5, CD40LG, UROD, IFNA2, FASLG, SEPSECS
10cholestasis30.6GPT, SLC17A5, ABCB7, F2
11alcoholic liver cirrhosis30.6AFP, GPT
12siderosis30.5GPT, UROD
13acute liver failure30.4F2, SLC17A5, GPT
14portal hypertension30.4SLC17A5, GPT, F2
15alcoholic hepatitis30.4F2, SLC17A5, GPT
16hepatic encephalopathy30.4GPT, F2, SLC17A5
17autoimmune hemolytic anemia30.3G6PD, CD40LG
18liver cirrhosis30.2SLC17A5, IFNA2, AFP, GPT, ABCB7, F2
19vogt-koyanagi-harada disease30.2FASLG, FAS
20scrub typhus30.1GPT, SLC17A5, CD40LG
21cryoglobulinemia30.1SLC17A5, CD40LG, IFNA2
22hepatitis c30.0SLC17A5, ABCB7, IFNA2, UROD, F2, FAS
23obesity29.9CISH, ABCB7, GPT, SLC17A5
24autoimmune hepatitis29.8GPT, SLC17A5, CD40LG, FAS, F2, SEPSECS
25thrombocytopenia29.8IFNA2, ABCB7, SLC17A5, GPT, F2, CD40LG
26liver cancer28.7ABCB7, CISH, SLC17A5, F2, GPT, AFP
27fulminant viral hepatitis10.9
28hepatocellular carcinoma10.8
29liver disease10.6
30polyarteritis nodosa10.5IFNA2
31hepatic coma10.5
32cholangiocarcinoma10.5
33intrahepatic cholangiocarcinoma10.4
34choledocholithiasis10.4SLC17A5, GPT
35mediterranean spotted fever10.4G6PD
36gastroschisis10.4AFP
37pyridoxine deficiency10.4GPT, SLC17A5
38hiv/aids10.4
39tuberculosis10.4
40hepatitis c virus10.4
41obstructive jaundice10.4GPT, SLC17A5
42vitamin k deficiency hemorrhagic disease10.4AFP, F2
43uveitis10.4CISH, IFNA2
44hellp syndrome10.4SLC17A5, GPT
45thyroiditis10.3
46placental abruption10.3F2, AFP
47hemorrhagic fever10.3CD40LG
48cholangitis10.3SLC17A5, SEPSECS, GPT
49typhoid fever10.3
50porphyria10.3

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Symptoms for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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MalaCards organs/tissues related to Viral Hepatitis:

32
Liver, Testes, Kidney, Thyroid, T cells, Endothelial, Bone, Monocytes, Nk cells, Spleen, Heart, Neutrophil, Brain, Spinal cord, Colon, Pancreas, Salivary gland, Breast

Animal Models for Viral Hepatitis or affiliated genes

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MGI Mouse Phenotypes related to Viral Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.7CD40LG, FASLG, FAS, CISH, AFP
2MP:00053857.2F2, ABCB7, G6PD, FAS, FASLG, CD40LG
3MP:00053977.1F2, CISH, G6PD, FAS, FASLG, CD40LG
4MP:00053847.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
5MP:00036317.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
6MP:00107686.4F2, ABCB7, AFP, G6PD, FAS, FASLG
7MP:00053766.0SLC17A5, F2, ABCB7, AFP, CISH, G6PD

Publications for Viral Hepatitis

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Articles related to Viral Hepatitis:

(show top 50)    (show all 908)
idTitleAuthorsYear
1
Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis. (24383922)
2014
2
Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology. (24032050)
2013
3
Chronic viral hepatitis is associated with low bone mineral density in HIV-infected patients, ANRS CO 3 Aquitaine Cohort. (23296138)
2013
4
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
5
Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma. (23983238)
2013
6
A practical scoring system for predicting cirrhosis in patients with chronic viral hepatitis. (23178625)
2012
7
Maternal and perinatal outcome in cases of fulminant viral hepatitis in late pregnancy. (22947378)
2012
8
The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil. (23270376)
2012
9
Diffusion-weighted magnetic resonance imaging for diagnosis of liver fibrosis and inflammation in chronic viral hepatitis: the performance of low or high B values and small or large regions of interest. (22261202)
2012
10
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
11
Hematologic and biochemical indices and viral hepatitis in liver transplant patients. (21440777)
2011
12
Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis. (21883739)
2011
13
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
14
Reactivation of viral hepatitis in immunosuppressed patients: an ounce of prevention is worth a pound of cure. (21093439)
2011
15
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
16
Establishment of a viral hepatitis surveillance system--Pakistan, 2009-2011. (21993343)
2011
17
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
18
Assessment of validity of INR system for patients with liver disease associated with viral hepatitis. (19915802)
2010
19
At last a global response to viral hepatitis. (21076557)
2010
20
Determination of the relationship of serum hyaluronic Acid levels to the degree of liver fibrosis in biopsies of patients with chronic viral hepatitis B and C. (22308134)
2010
21
Advances in viral hepatitis: 50 years of Australian gastroenterology. (19799691)
2009
22
Viral hepatitis in solid organ transplant recipients. (20070671)
2009
23
HIV/viral hepatitis coinfection: the Immunology Center experience. (19685638)
2009
24
Vascular and glomerular manifestations of viral hepatitis B and C: a review. (19891305)
2009
25
Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. (18795698)
2008
26
HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in the Czech population. (17573946)
2007
27
Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. (17192324)
2007
28
Relationship of CT manifestations of chronic viral hepatitis with severity of illness]. (15760552)
2005
29
Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases. (16226105)
2005
30
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
31
Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C. (15232637)
2004
32
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
33
Influence of plasma exchange on serum cytokines in severe viral hepatitis patients]. (12857473)
2003
34
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
35
Sustained response with negative serum HCV-mRNA and disappearance of antibodies after interferon-alpha therapy in a kidney transplant recipient with chronic active viral hepatitis C. (12832744)
2003
36
Apoptosis in viral hepatitis B and C. (11480324)
2001
37
Surveillance for hepatocellular carcinoma in patients with chronic viral hepatitis in the United States of America. (11350553)
2001
38
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. (11355694)
2001
39
Changes in the levels of acute phase proteins in viral hepatitis]. (11270948)
2000
40
Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? (11054721)
2000
41
Albumin gradient and portal vein velocity in severe viral hepatitis patients complicated with ascites. (11149035)
2000
42
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999
43
Host factors in chronic viral hepatitis. (9408970)
1997
44
The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. (8871871)
1996
45
Relation between treatment efficacy and cumulative dose of alpha interferon in chronic hepatitis B. European Concerted Action on Viral Hepatitis (Eurohep). (9007705)
1996
46
Interferon and cyclosporin A in the treatment of fulminant viral hepatitis. (7719417)
1995
47
Measurement of serum alcohol dehydrogenase activity at different pH-values during the course of viral hepatitis in children. (2230670)
1990
48
Antibodies to hepatitis C virus in non-A non-B fulminant viral hepatitis. (2112102)
1990
49
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon. (3897068)
1985
50
Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor. (6402856)
1983

Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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Pathways related to Viral Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FASLG, FAS
2
Show member pathways
9.3FASLG, FAS
3
Show member pathways
9.3FAS, FASLG
4
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0IFNA2, FASLG, FAS
5
Show member pathways
Immune response CD16 signaling in NK cells60
9.0IFNA2, FASLG, FAS
68.9FASLG, FAS, CISH
7
Show member pathways
8.5FAS, FASLG, CD40LG
8
Show member pathways
8.2CD40LG, IFNA2, FASLG, FAS
9
Show member pathways
8.0F2, FAS, FASLG, IFNA2, CD40LG

Compounds for genes affiliated with Viral Hepatitis

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Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1hepaplastin4410.0F2, GPT, SLC17A5
2adefovir449.8GPT, IFNA2, SLC17A5
3aminopyrine449.8F2, SLC17A5, GPT
4lamivudine44 50 1111.7F2, GPT, IFNA2, SLC17A5
5silymarin449.5SLC17A5, GPT, F2, ABCB7
6nevirapine44 50 1111.4GPT, SLC17A5, ABCB7
7gamma globulin449.3IFNA2, CD40LG, SLC17A5
8phenobarbital44 28 50 1112.2SLC17A5, GPT, G6PD, UROD
9acetaminophen44 2 50 24 1113.2GPT, F2, G6PD, SLC17A5, AFP
10azathioprine44 2 50 1112.1AFP, G6PD, IFNA2, GPT
11simvastatin44 50 61 28 24 1114.1AFP, FASLG, GPT, F2, SLC17A5
12vitamin-e449.1GPT, G6PD, IFNA2, SLC17A5, ABCB7
13methotrexate50 44 1111.0SLC17A5, FASLG, GPT, F2, AFP
14neopterin449.0SLC17A5, CD40LG, IFNA2, GPT
15uric acid44 2410.0SLC17A5, ABCB7, GPT, G6PD, AFP
16ifn-alpha448.8CISH, FASLG, IFNA2, FAS, GPT
17mitomycin c448.7IFNA2, AFP, FAS, FASLG
18vitamin b12448.7SLC17A5, GPT, AFP, G6PD, CD40LG
19hyaluronic acid44 249.6FASLG, F2, CD40LG, GPT, SLC17A5
20thalidomide44 50 61 1111.6FASLG, AFP, IFNA2, CD40LG
21ethanol44 50 24 1111.5FASLG, ABCB7, GPT, AFP, UROD, SLC17A5
22vitamin a44 24 1110.5FAS, SLC17A5, CD40LG, IFNA2, GPT
23ursodeoxycholic acid44 24 1110.5CD40LG, IFNA2, ABCB7, F2, SLC17A5, GPT
24ribavirin44 50 1110.4GPT, SLC17A5, G6PD, IFNA2, CD40LG, AFP
25polyethylene glycol448.4IFNA2, F2, AFP, SLC17A5, G6PD, CD40LG
26tamoxifen44 50 28 1111.4FASLG, F2, G6PD, SLC17A5, FAS, IFNA2
27ivig448.4GPT, SEPSECS, FAS, FASLG, CD40LG
28fibrinogen448.3SLC17A5, CD40LG, AFP, GPT, F2, ABCB7
29iron44 249.3IFNA2, SLC17A5, UROD, ABCB7, GPT, AFP
30phosphatidylserine44 28 1110.1F2, G6PD, FASLG, FAS, CD40LG
31thyroxine44 248.9ABCB7, GPT, AFP, CD40LG, G6PD, SLC17A5
32ascorbic acid44 248.9FASLG, SLC17A5, IFNA2, FAS, CD40LG, G6PD
33oxygen44 248.8IFNA2, ABCB7, AFP, G6PD, FAS, SLC17A5
34agar447.8FASLG, AFP, G6PD, FAS, CD40LG, IFNA2
35cyclosporin a44 28 619.8GPT, SEPSECS, F2, FAS, FASLG, CD40LG
36lipid447.8ABCB7, SLC17A5, IFNA2, G6PD, CISH, AFP
37doxorubicin44 50 119.7AFP, CD40LG, G6PD, IFNA2, FASLG, FAS
38glucose447.7FASLG, G6PD, IFNA2, SLC17A5, AFP, ABCB7
39n acetylcysteine447.7GPT, FAS, F2, SLC17A5, G6PD, CD40LG
40alanine447.5CD40LG, FASLG, AFP, GPT, ABCB7, F2
41cisplatin44 50 61 1110.5SLC17A5, CD40LG, FASLG, AFP, G6PD, FAS
42heparin44 28 24 1110.4FASLG, CD40LG, F2, ABCB7, FAS, AFP
43estrogen447.4F2, CD40LG, UROD, AFP, CISH, G6PD
44actinomycin d447.4FASLG, CD40LG, FAS, AFP, G6PD
45creatinine447.3CD40LG, ABCB7, F2, SLC17A5, GPT, AFP
46epinephrine44 24 119.3AFP, F2, FAS, IFNA2, CD40LG, SLC17A5
47testosterone44 61 24 1110.2FASLG, FAS, G6PD, AFP, ABCB7, CD40LG
48serine446.9F2, FAS, AFP, CISH, FASLG, CD40LG
49lactate446.8F2, GPT, AFP, G6PD, FAS, ABCB7
50aspartate446.5CD40LG, SLC17A5, IFNA2, FASLG, AFP, G6PD

GO Terms for genes affiliated with Viral Hepatitis

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Cellular components related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CD40LG, FASLG, FAS
2extracellular spaceGO:0056157.9CD40LG, IFNA2, FASLG, AFP, F2

Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.4FASLG, FAS
2necroptotic signaling pathwayGO:0975279.4FASLG, FAS
3extrinsic apoptotic signaling pathwayGO:0971919.3FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.2FAS, FASLG
5positive regulation of endothelial cell apoptotic processGO:20003539.1CD40LG, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.0FASLG, FAS

Molecular functions related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1CD40LG, FASLG
2cytokine activityGO:0051258.5CD40LG, IFNA2, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
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Sources for Viral Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet