MCID: VRL010
MIFTS: 61

Viral Hepatitis malady

Infectious diseases category

Summaries for Viral Hepatitis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are Allograft rejection and Toll-like receptor signaling pathway. The compounds alanine and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:63 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

viral hepatitis 8 10 44 60
unspecified viral hepatitis with hepatic coma 8
viral hepatitis with hepatic coma 8
hepatitis, viral, animal 60
hepatitis, viral, human 60
animal viral hepatitis 8
human viral hepatitis 8


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Disease Ontology8 DOID:1884
MeSH34 D006524

Related Diseases for Viral Hepatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a Hepatitis
viral hepatitis Hepatitis C Virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.1IFNA1, GPT, SLC17A5
2hepatitis a31.7F2
3hepatitis c31.5HFE, CD40LG, GPT, ABCB7, F2, SLC17A5
4hepatitis b31.5ABCB7, F2, SLC17A5, GGT1, PTMA, TMPO
5hepatocellular carcinoma31.1CISH, AFP, HFE, GPT, ABCB7, F2
6hepatitis e31.0CD40LG, GPT
7alcoholic hepatitis30.8GPT, F2, SLC17A5, GGT1
8autoimmune hepatitis30.7SEPSECS
9cholangiocarcinoma30.6GGT1, AFP
10liver cirrhosis30.5SEPSECS, PTMA, IFNA2, IFNA1, AKR1A1, CISH
11tuberculosis30.5AKR1A1
12thyroiditis30.4FASLG, IFNA1
13alcohol abuse30.3AKR1A1, HFE, GPT, ABCB7, SLC17A5, GGT1
14cholestasis30.3GPT, ABCB7, F2, SLC17A5, GGT1
15fatty liver disease30.3HFE, GPT, ABCB7, SLC17A5, GGT1
16porphyria30.3HFE, UROD
17hepatitis d30.3IFNA2, IFNA1, GPT
18thrombocytopenia30.2IFNA2, IFNA1, HFE, CD40LG, GPT, ABCB7
19acute pancreatitis30.2SLC17A5, ABCB7, GPT
20pancreatitis30.2SLC17A5, GGT1
21porphyria cutanea tarda30.2HFE, UROD
22lichen planus30.2IFNA2
23hemolytic anemia30.2IFNA2, G6PD, HFE
24viral infectious disease30.1IFNA2, IFNA1, FAS, FASLG, UROD, G6PD
25diabetes mellitus30.1G6PD, HFE, CD40LG, GPT, GGT1
26hypertension30.1GGT1, F2
27herpes simplex30.1TMPO, IFNA1
28malaria30.1G6PD
29acute liver failure30.1GPT, F2, SLC17A5
30influenza30.1TMPO, IFNA1
31autoimmune hemolytic anemia30.1CD40LG, G6PD
32alcohol dependence30.1GGT1
33vitiligo30.1G6PD
34breast cancer29.9FAS, G6PD, AKR1A1, CISH, PTMA, TMPO
35obesity29.9CISH, HFE, GPT, ABCB7, SLC17A5, GGT1
36cryoglobulinemia29.9IFNA2, IFNA1, CD40LG, SLC17A5
37portal hypertension29.9GPT, F2, SLC17A5, GGT1
38multiple sclerosis29.9IFNA1, FASLG, TMPO
39peritonitis29.9F2
40arthritis29.9HFE, CISH
41schistosomiasis29.9CD40LG
42scrub typhus29.9CD40LG, GPT, SLC17A5
43siderosis29.9UROD, HFE, GPT
44colon cancer29.9FASLG, FAS
45hemochromatosis29.9HFE, UROD
46hepatic encephalopathy29.9GPT, F2, SLC17A5
47cholecystitis29.9GPT
48alcoholic liver cirrhosis29.9AFP, GPT
49vogt-koyanagi-harada disease29.9FASLG, FAS
50glomerulonephritis29.9CD40LG

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Clinical Features for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Viral Hepatitis

Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Search CenterWatch for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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32MalaCards
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MalaCards organs/tissues related to Viral Hepatitis:

32
Liver, Kidney, Testes, T cells, Thyroid, Endothelial, Nk cells, Monocytes, Bone, Heart, Spinal cord, Spleen, Colon, B cells, Lymph node, Brain, Breast, Salivary gland, Pancreas

Animal Models for Viral Hepatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Viral Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8GGT1, FAS, FASLG, UROD, G6PD, AKR1A1
2MP:000539710.8FASLG, G6PD, AKR1A1, HFE, CD40LG, F2
3MP:001076810.6AKR1A1, G6PD, UROD, FASLG, FAS, AFP

Publications for Viral Hepatitis

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Sources:
50PubMed
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Articles related to Viral Hepatitis:

(show top 50)    (show all 1368)
idTitleAuthorsYear
1
Endogenous IFNI> in Viral Hepatitis Patients. (24433037)
2014
2
Chronic viral hepatitis is associated with low bone mineral density in HIV-infected patients, ANRS CO 3 Aquitaine Cohort. (23296138)
2013
3
Sirolimus conversion may suppress viral replication in hepatitis C virus-positive renal transplant candidates. (24128134)
2013
4
Safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and chronic viral hepatitis B or C: a retrospective, multicentre study in a clinical setting. (22985451)
2013
5
Viral hepatitis and HIV: update and management. (23792670)
2013
6
Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotypes 2a and 2b and high viral load. (24281016)
2013
7
Modeling chronic hepatitis B or C virus infection during antiviral therapy using an analogy to enzyme kinetics: long-term viral dynamics without rebound and oscillation. (24290917)
2013
8
Is sustained virological response a marker of treatment efficacy in patients with chronic hepatitis C viral infection with no response or relapse to previous antiviral intervention? (24349487)
2013
9
Hepatocellular carcinoma surveillance at 4- vs. 12-month intervals for patients with chronic viral hepatitis: a randomized study in community. (23318478)
2013
10
HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients. (24170093)
2013
11
High levels of circulating HMGB1 as a biomarker of acute liver failure in patients with viral hepatitis E. (23682703)
2013
12
The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil. (23270376)
2012
13
Quantification of hepatic iron concentration in chronic viral hepatitis: usefulness of T2-weighted single-shot spin-echo echo-planar MR imaging. (22439008)
2012
14
Barriers faced by migrants in accessing healthcare for viral hepatitis infection. (22151101)
2012
15
Predictors of mental and physical health in non-cirrhotic patients with viral hepatitis: a case control study. (22850263)
2012
16
Epidemiology of viral hepatitis in Saudi Arabia: are we off the hook? (23150019)
2012
17
A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea. (22049041)
2011
18
Viral hepatitis as an occupational disease in Poland. (22087191)
2011
19
The liver-cytokine-brain circuit in interferon-based treatment of patients with chronic viral hepatitis. (21762284)
2011
20
Liver biopsies in chronic viral hepatitis: beyond grading and staging. (21970487)
2011
21
Evidence for the involvement of TGF-I^1-CTGF axis in liver fibrogenesis secondary to hepatic viral infection. (21424084)
2011
22
Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis. (19330428)
2010
23
Viral hepatitis. (20223109)
2010
24
Is it acalculous cholecystitis or reactive/viral pericholecystits in acute hepatitis? (21340313)
2010
25
Viral hepatitis a to e in South mediterranean countries. (21415943)
2010
26
Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis. (20728234)
2010
27
An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads. (19372703)
2009
28
Assessing the quality of care in a regional integrated viral hepatitis clinic in British Columbia: a cross-sectional study. (19820440)
2009
29
A case of acute rejection shortly after initiation of lamivudine therapy in a simultaneous pancreas and kidney recipient with viral hepatitis type B. (19725907)
2009
30
Anemia--a complication of antiviral treatment in chronic viral hepatitis C. (20446436)
2009
31
A study of viral hepatitis during pregnancy in Nepal Medical College Teaching Hospital. (20334069)
2009
32
Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. (17192324)
2007
33
Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response. (16973626)
2006
34
Growth factors and the hystologic picture of the liver in chronic viral hepatitis and hepatic cirrhosis]. (17087191)
2006
35
Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B. (16437596)
2005
36
Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. (16122776)
2005
37
Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response. (15225166)
2004
38
Recurrent demyelinating myelitis associated with hepatitis C viral infection. (15450779)
2004
39
Involvement of TRAIL and its receptors in viral hepatitis. (12475902)
2003
40
Immunohistochemical evidence of lactoferrin in hepatic biopsies of patients with viral or cryptogenetic chronic liver disease. (12371135)
2002
41
Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis. (12453280)
2002
42
Role of tumor necrosis factor receptor 1 and Fas antigen in hepatocellular apoptosis of viral hepatitis B patients]. (11782299)
2001
43
Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin. (11100362)
2000
44
Zadaxin (thymosin alpha1) for the treatment of viral hepatitis. (15992078)
1999
45
Membranoproliferative glomerulonephritis associated with hepatitis B and C viral infections: from viruslike particles in the cryoprecipitate to viral localization in paramesangial deposits, problematic investigations prone to artifacts. (8076152)
1994
46
Serum levels of interleukin-1 alpha, interleukin-1 beta, interleukin-6, and tumor necrosis factor in patients with acute viral hepatitis. (8161626)
1994
47
Hepatic reactions in the course of viral meningoencephalitis in patients hospitalized in 1985-1989]. (8249395)
1993
48
alpha-Interferon in the treatment of chronic viral hepatitis: effects on fibrogenesis serum markers. (8340603)
1993
49
Preliminary experience with alpha-2b-interferon therapy of viral hepatitis in liver allograft recipients. (1733058)
1992
50
2'-5' oligoadenylate synthetase activity in patients with acute viral hepatitis and chronic type B hepatitis, and its clinical significance]. (1715348)
1991

Genetic Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Viral Hepatitis

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1alanine4411.4PTMA, IFNA1, SLC17A5, F2, ABCB7, IFNA2
2aspartate4411.3AFP, TMPO, SLC17A5, F2, ABCB7, GPT
3lactate4411.3ABCB7, FAS, FASLG, GGT1, SLC17A5, G6PD
4cisplatin44 49 59 1114.3AFP, IFNA1, FAS, IFNA2, CD40LG, SLC17A5
5ribavirin44 49 1113.3GPT, CD40LG, G6PD, IFNA1, IFNA2, SLC17A5
6n acetylcysteine4411.2F2, FAS, G6PD, CD40LG, GPT, AKR1A1
7ethanol44 49 11 2414.2GGT1, SLC17A5, HFE, FASLG, ABCB7, GPT
8ursodeoxycholic acid44 11 2413.2F2, GGT1, SLC17A5, ABCB7, GPT, CD40LG
9cyclosporin a44 28 5913.2IFNA1, FAS, FASLG, TMPO, GPT, CD40LG
10thyroxine44 2412.2CD40LG, GGT1, SLC17A5, ABCB7, GPT, IFNA2
11iron44 2412.2HFE, IFNA2, ABCB7, GPT, GGT1, SLC17A5
12creatinine4411.2SLC17A5, FAS, GGT1, AFP, F2, ABCB7
13epinephrine44 11 2413.2AFP, F2, G6PD, FASLG, FAS, CD40LG
14ifn-alpha4411.2GPT, CISH, FASLG, FAS, IFNA1, IFNA2
15ascorbic acid44 2412.2CD40LG, HFE, GGT1, IFNA2, G6PD, FASLG
16polyethylene glycol4411.2CD40LG, IFNA1, SLC17A5, IFNA2, G6PD, AFP
17doxorubicin44 49 1113.1AFP, AKR1A1, FASLG, CD40LG, IFNA1, IFNA2
18testosterone44 59 11 2414.1HFE, ABCB7, CD40LG, SLC17A5, GGT1, G6PD
19vitamin b124411.1GPT, SLC17A5, CD40LG, GGT1, AFP, G6PD
20adefovir4411.1SLC17A5, IFNA2, GPT, PTMA, IFNA1
21phenobarbital44 28 1113.1G6PD, AKR1A1, UROD, GPT, SLC17A5, GGT1
22nash4411.0GPT, SLC17A5, AKR1A1, HFE, GGT1
23uric acid44 2412.0ABCB7, HFE, AFP, G6PD
24vitamin-e4411.0SLC17A5, GGT1, GPT, G6PD, IFNA2, ABCB7
25zidovudine44 1112.0TMPO, PTMA, SLC17A5, GPT, IFNA2, IFNA1
26tamoxifen44 49 28 1114.0SLC17A5, FASLG, IFNA1, G6PD, GGT1
27glucose4411.0SLC17A5, CISH, FASLG, IFNA2, TMPO
28entecavir4411.0GPT, IFNA1, PTMA, IFNA2
29lamivudine44 1112.0PTMA, SLC17A5, F2
30serine4411.0FGL2, AFP, SEPSECS, G6PD, AKR1A1, CISH
31agar4411.0AFP, FASLG, FAS, G6PD, PTMA
32acetaminophen44 2 49 11 2415.0SLC17A5, GGT1, GPT
33silymarin4410.9GPT, ABCB7, F2, SLC17A5, GGT1
34mycophenolate mofetil44 49 1112.9GGT1, GPT, IFNA1, SEPSECS, CD40LG
35aminopyrine4410.9GGT1, SLC17A5, F2, GPT
36fibrinogen4410.9AFP, CD40LG, FGL2, GPT, ABCB7, F2
37vitamin a44 11 2412.9IFNA2, FAS, AKR1A1
38estrogen4410.9UROD
39heparin44 28 11 2413.9FAS, FASLG, AFP, ABCB7, CD40LG
40amantadine44 1111.9IFNA2, IFNA1, PTMA, GPT
41gamma globulin4410.9GGT1, IFNA2
42cyclophosphamide44 49 1112.8AFP, FASLG, IFNA1, IFNA2, PTMA, G6PD
43indomethacin44 59 28 1113.8TMPO, AKR1A1, GGT1
44hyaluronic acid44 2411.8CD40LG, GGT1, SLC17A5, F2, FASLG, GPT
45ivig4410.8CD40LG, SEPSECS, GPT
46lipid4410.7GGT1, SLC17A5, ABCB7, GPT, HFE, CISH
47neopterin4410.7CD40LG, IFNA1, GPT, SLC17A5, IFNA2
48thalidomide44 49 59 1113.7CD40LG, FASLG, IFNA2, IFNA1, AFP
49nevirapine44 49 1112.6GGT1, SLC17A5, ABCB7, GPT
505-hydroxytryptophol4410.3GPT, SLC17A5, AKR1A1

GO Terms for genes affiliated with Viral Hepatitis

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16Gene Ontology
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Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.5FASLG, FAS
2inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
3positive regulation of endothelial cell apoptotic processGO:200035310.2CD40LG, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Viral Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet