MCID: VRL010
MIFTS: 54

Viral Hepatitis malady

Genetic diseases, Infectious diseases, Liver diseases, Rare diseases, Gastrointestinal diseases categories

Summaries for Viral Hepatitis

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Wikipedia:63 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

MalaCards based summary: Viral Hepatitis, also known as viral hepatitis with hepatic coma, is related to hepatitis a and liver disease. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are African trypanosomiasis and Death Receptor Signalling. The compounds hepaplastin and adefovir have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:9 A hepatitis that involves viral infection causing inflammation of the liver.

Aliases & Classifications for Viral Hepatitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 3CDC, 60UMLS, 33MeSH, 25ICD10
See all sources

Viral Hepatitis, Aliases & Descriptions:

Name: Viral Hepatitis 9 11 43 3 60
Viral Hepatitis with Hepatic Coma 9 60
Unspecified Viral Hepatitis with Hepatic Coma 9
Hepatitis, Viral, Animal 60
 
Hepatitis, Viral, Human 60
Animal Viral Hepatitis 9
Human Viral Hepatitis 9


Classifications:



External Ids:

Disease Ontology9 DOID:1884
MeSH33 D006524

Related Diseases for Viral Hepatitis

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Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis C
Hepatitis D Hepatitis a
Hepatitis E viral hepatitis

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a32.2F2
2liver disease31.5F2, SEPSECS
3hepatitis b31.2ABCB7, GPT, AFP, IFNA2, SLC17A5, F2
4hepatitis e31.1GPT, CD40LG
5hepatitis d30.9IFNA2, GPT
6cholecystitis30.8GPT
7alcohol abuse30.7GPT, SLC17A5, ABCB7
8fatty liver disease30.7ABCB7, GPT, SLC17A5
9acute pancreatitis30.6SLC17A5, GPT, ABCB7
10hepatitis30.6SLC17A5, CD40LG, UROD, IFNA2, FASLG, SEPSECS
11cholestasis30.6GPT, SLC17A5, ABCB7, F2
12alcoholic liver cirrhosis30.5AFP, GPT
13siderosis30.5GPT, UROD
14acute liver failure30.4F2, SLC17A5, GPT
15portal hypertension30.4SLC17A5, GPT, F2
16alcoholic hepatitis30.4F2, SLC17A5, GPT
17hepatic encephalopathy30.4GPT, F2, SLC17A5
18autoimmune hemolytic anemia30.4G6PD, CD40LG
19liver cirrhosis30.2SLC17A5, IFNA2, AFP, GPT, ABCB7, F2
20vogt-koyanagi-harada disease30.2FASLG, FAS
21scrub typhus30.1GPT, SLC17A5, CD40LG
22cryoglobulinemia30.1SLC17A5, CD40LG, IFNA2
23alcohol dependence30.0GPT, SLC17A5, G6PD, ABCB7
24hepatitis c30.0SLC17A5, ABCB7, IFNA2, UROD, F2, FAS
25obesity29.9CISH, ABCB7, GPT, SLC17A5
26autoimmune hepatitis29.8GPT, SLC17A5, CD40LG, FAS, F2, SEPSECS
27thrombocytopenia29.7IFNA2, ABCB7, SLC17A5, GPT, F2, CD40LG
28hepatocellular carcinoma29.7ABCB7, CISH, SLC17A5, F2, GPT, AFP
29chronic lymphocytic leukemia29.6CD40LG, FASLG, FAS
30leukemia29.1FASLG, FAS, CISH, IFNA2, CD40LG
31fulminant viral hepatitis10.9
32polyarteritis nodosa10.5IFNA2
33hepatic coma10.5
34cholangiocarcinoma10.5
35intrahepatic cholangiocarcinoma10.4
36gastroschisis10.4AFP
37mediterranean spotted fever10.4G6PD
38choledocholithiasis10.4SLC17A5, GPT
39pyridoxine deficiency10.4GPT, SLC17A5
40hepatitis c virus10.4
41tuberculosis10.4
42obstructive jaundice10.4GPT, SLC17A5
43vitamin k deficiency hemorrhagic disease10.4AFP, F2
44uveitis10.4CISH, IFNA2
45hellp syndrome10.4SLC17A5, GPT
46glucose-6-phosphate dehydrogenase deficiency10.3
47thyroiditis10.3
48placental abruption10.3F2, AFP
49hemorrhagic fever10.3CD40LG
50porphyria cutanea tarda10.3

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Symptoms for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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MalaCards organs/tissues related to Viral Hepatitis:

31
Liver, Testes, Kidney, Thyroid, T cells, Bone, Endothelial, Spleen, Monocytes, Nk cells, Heart, Neutrophil, Brain, Spinal cord, Colon, Pancreas, Salivary gland, Breast, B cells

Animal Models for Viral Hepatitis or affiliated genes

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MGI Mouse Phenotypes related to Viral Hepatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.7CD40LG, FAS, CISH, AFP, FASLG
2MP:00053857.2CD40LG, ABCB7, F2, G6PD, FAS, FASLG
3MP:00053977.1F2, CISH, G6PD, FAS, FASLG, CD40LG
4MP:00053847.0ABCB7, F2, FAS, SLC17A5, G6PD, CD40LG
5MP:00036317.0ABCB7, FAS, G6PD, FASLG, CD40LG, F2
6MP:00107686.4F2, CD40LG, UROD, FASLG, FAS, G6PD
7MP:00053766.0FAS, SLC17A5, CD40LG, UROD, FASLG, G6PD

Publications for Viral Hepatitis

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Articles related to Viral Hepatitis:

(show top 50)    (show all 932)
idTitleAuthorsYear
1
Nucleic Acid-based approaches for detection of viral hepatitis. (25789132)
2015
2
Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis. (24383922)
2014
3
Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology. (24032050)
2013
4
Chronic viral hepatitis is associated with low bone mineral density in HIV-infected patients, ANRS CO 3 Aquitaine Cohort. (23296138)
2013
5
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
6
Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma. (23983238)
2013
7
Aplastic anemia following viral hepatitis. (24201921)
2013
8
A practical scoring system for predicting cirrhosis in patients with chronic viral hepatitis. (23178625)
2012
9
Maternal and perinatal outcome in cases of fulminant viral hepatitis in late pregnancy. (22947378)
2012
10
The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil. (23270376)
2012
11
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
12
Hematologic and biochemical indices and viral hepatitis in liver transplant patients. (21440777)
2011
13
Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis. (21883739)
2011
14
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
15
Reactivation of viral hepatitis in immunosuppressed patients: an ounce of prevention is worth a pound of cure. (21093439)
2011
16
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
17
Establishment of a viral hepatitis surveillance system--Pakistan, 2009-2011. (21993343)
2011
18
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
19
Assessment of validity of INR system for patients with liver disease associated with viral hepatitis. (19915802)
2010
20
At last a global response to viral hepatitis. (21076557)
2010
21
Advances in viral hepatitis: 50 years of Australian gastroenterology. (19799691)
2009
22
Viral hepatitis in solid organ transplant recipients. (20070671)
2009
23
HIV/viral hepatitis coinfection: the Immunology Center experience. (19685638)
2009
24
Vascular and glomerular manifestations of viral hepatitis B and C: a review. (19891305)
2009
25
Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. (18795698)
2008
26
HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in the Czech population. (17573946)
2007
27
Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. (17192324)
2007
28
Relationship of CT manifestations of chronic viral hepatitis with severity of illness]. (15760552)
2005
29
Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases. (16226105)
2005
30
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
31
Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C. (15232637)
2004
32
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
33
Influence of plasma exchange on serum cytokines in severe viral hepatitis patients]. (12857473)
2003
34
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
35
Sustained response with negative serum HCV-mRNA and disappearance of antibodies after interferon-alpha therapy in a kidney transplant recipient with chronic active viral hepatitis C. (12832744)
2003
36
Apoptosis in viral hepatitis B and C. (11480324)
2001
37
Surveillance for hepatocellular carcinoma in patients with chronic viral hepatitis in the United States of America. (11350553)
2001
38
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. (11355694)
2001
39
Changes in the levels of acute phase proteins in viral hepatitis]. (11270948)
2000
40
Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? (11054721)
2000
41
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999
42
Host factors in chronic viral hepatitis. (9408970)
1997
43
The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. (8871871)
1996
44
Relation between treatment efficacy and cumulative dose of alpha interferon in chronic hepatitis B. European Concerted Action on Viral Hepatitis (Eurohep). (9007705)
1996
45
Interferon and cyclosporin A in the treatment of fulminant viral hepatitis. (7719417)
1995
46
Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis. (1907761)
1991
47
Measurement of serum alcohol dehydrogenase activity at different pH-values during the course of viral hepatitis in children. (2230670)
1990
48
Antibodies to hepatitis C virus in non-A non-B fulminant viral hepatitis. (2112102)
1990
49
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon. (3897068)
1985
50
Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor. (6402856)
1983

Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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Pathways related to Viral Hepatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FASLG, FAS
2
Show member pathways
9.3FASLG, FAS
3
Show member pathways
9.3FAS, FASLG
4
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0IFNA2, FASLG, FAS
5
Show member pathways
Immune response CD16 signaling in NK cells58
9.0IFNA2, FASLG, FAS
68.9FASLG, FAS, CISH
7
Show member pathways
8.5FAS, FASLG, CD40LG
8
Show member pathways
8.2CD40LG, IFNA2, FASLG, FAS
9
Show member pathways
8.0F2, FAS, FASLG, IFNA2, CD40LG

Compounds for genes affiliated with Viral Hepatitis

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Compounds related to Viral Hepatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1hepaplastin4310.0F2, GPT, SLC17A5
2adefovir439.8GPT, IFNA2, SLC17A5
3aminopyrine439.8F2, SLC17A5, GPT
4lamivudine43 49 1211.7F2, GPT, IFNA2, SLC17A5
5silymarin439.5SLC17A5, GPT, F2, ABCB7
6nevirapine43 49 1211.4GPT, SLC17A5, ABCB7
7gamma globulin439.3IFNA2, CD40LG, SLC17A5
8phenobarbital43 28 49 1212.2SLC17A5, GPT, G6PD, UROD
9acetaminophen43 2 49 24 1213.2GPT, F2, G6PD, SLC17A5, AFP
10azathioprine43 2 49 1212.1AFP, G6PD, IFNA2, GPT
11simvastatin43 49 59 28 24 1214.1AFP, FASLG, GPT, F2, SLC17A5
12vitamin-e439.1GPT, G6PD, IFNA2, SLC17A5, ABCB7
13methotrexate49 43 1211.0SLC17A5, FASLG, GPT, F2, AFP
14neopterin439.0SLC17A5, CD40LG, IFNA2, GPT
15uric acid43 2410.0SLC17A5, ABCB7, GPT, G6PD, AFP
16ifn-alpha438.8CISH, FASLG, IFNA2, FAS, GPT
17mitomycin c438.7IFNA2, AFP, FAS, FASLG
18vitamin b12438.7SLC17A5, GPT, AFP, G6PD, CD40LG
19hyaluronic acid43 249.6FASLG, F2, CD40LG, GPT, SLC17A5
20thalidomide43 49 59 1211.6FASLG, AFP, IFNA2, CD40LG
21ethanol43 49 24 1211.5FASLG, ABCB7, GPT, AFP, UROD, SLC17A5
22vitamin a43 24 1210.5FAS, SLC17A5, CD40LG, IFNA2, GPT
23ursodeoxycholic acid43 24 1210.5CD40LG, IFNA2, ABCB7, F2, SLC17A5, GPT
24ribavirin43 49 1210.4GPT, SLC17A5, G6PD, IFNA2, CD40LG, AFP
25polyethylene glycol438.4IFNA2, F2, AFP, SLC17A5, G6PD, CD40LG
26tamoxifen43 49 28 1211.4FASLG, F2, G6PD, SLC17A5, FAS, IFNA2
27ivig438.4GPT, SEPSECS, FAS, FASLG, CD40LG
28fibrinogen438.3SLC17A5, CD40LG, AFP, GPT, F2, ABCB7
29iron43 249.3IFNA2, SLC17A5, UROD, ABCB7, GPT, AFP
30phosphatidylserine43 28 1210.1F2, G6PD, FASLG, FAS, CD40LG
31thyroxine43 248.9ABCB7, GPT, AFP, CD40LG, G6PD, SLC17A5
32ascorbic acid43 248.9FASLG, SLC17A5, IFNA2, FAS, CD40LG, G6PD
33oxygen43 248.8IFNA2, ABCB7, AFP, G6PD, FAS, SLC17A5
34agar437.8FASLG, AFP, G6PD, FAS, CD40LG, IFNA2
35cyclosporin a43 28 599.8GPT, SEPSECS, F2, FAS, FASLG, CD40LG
36lipid437.8ABCB7, SLC17A5, IFNA2, G6PD, CISH, AFP
37doxorubicin43 49 129.7AFP, CD40LG, G6PD, IFNA2, FASLG, FAS
38glucose437.7FASLG, G6PD, IFNA2, SLC17A5, AFP, ABCB7
39n acetylcysteine437.7GPT, FAS, F2, SLC17A5, G6PD, CD40LG
40alanine437.5CD40LG, FASLG, AFP, GPT, ABCB7, F2
41cisplatin43 49 59 1210.5SLC17A5, CD40LG, FASLG, AFP, G6PD, FAS
42heparin43 28 24 1210.4FASLG, CD40LG, F2, ABCB7, FAS, AFP
43estrogen437.4F2, CD40LG, UROD, AFP, CISH, G6PD
44actinomycin d437.4FASLG, CD40LG, FAS, AFP, G6PD
45creatinine437.3CD40LG, ABCB7, F2, SLC17A5, GPT, AFP
46epinephrine43 24 129.3AFP, F2, FAS, IFNA2, CD40LG, SLC17A5
47testosterone43 59 24 1210.2FASLG, FAS, G6PD, AFP, ABCB7, CD40LG
48serine436.9F2, FAS, AFP, CISH, FASLG, CD40LG
49lactate436.8F2, GPT, AFP, G6PD, FAS, ABCB7
50aspartate436.5CD40LG, SLC17A5, IFNA2, FASLG, AFP, G6PD

GO Terms for genes affiliated with Viral Hepatitis

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Cellular components related to Viral Hepatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CD40LG, FASLG, FAS
2extracellular spaceGO:00056157.9CD40LG, IFNA2, FASLG, AFP, F2

Biological processes related to Viral Hepatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00069259.4FASLG, FAS
2necroptotic signaling pathwayGO:00975279.4FASLG, FAS
3extrinsic apoptotic signaling pathwayGO:00971919.3FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.2FAS, FASLG
5positive regulation of endothelial cell apoptotic processGO:020003539.1CD40LG, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.0FASLG, FAS

Molecular functions related to Viral Hepatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.1CD40LG, FASLG
2cytokine activityGO:00051258.5CD40LG, IFNA2, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
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Sources for Viral Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet