MCID: VRL010
MIFTS: 64

Viral Hepatitis malady

Infectious diseases, Gastrointestinal diseases, Liver diseases, Rare diseases, Immune diseases categories
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Summaries for Viral Hepatitis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are African trypanosomiasis and Death Receptor Signalling. The compounds hepaplastin and adefovir have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:65 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

viral hepatitis 8 10 45 62
unspecified viral hepatitis with hepatic coma 8
viral hepatitis with hepatic coma 8
hepatitis, viral, animal 62
hepatitis, viral, human 62
animal viral hepatitis 8
human viral hepatitis 8


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Disease Ontology8 DOID:1884
MeSH35 D006524

Related Diseases for Viral Hepatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis B
Hepatitis D Hepatitis a
Hepatitis E Hepatitis
viral hepatitis Hepatitis C Virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.3GPT, SLC17A5
2hepatitis a31.5F2
3hepatitis b31.4ABCB7, GPT, AFP, IFNA2, SLC17A5, F2
4hepatitis c31.0SLC17A5, ABCB7, IFNA2, UROD, F2, FAS
5hepatocellular carcinoma30.8ABCB7, CISH, SLC17A5, F2, GPT, AFP
6hepatitis e30.8GPT, CD40LG
7alcohol abuse30.5GPT, SLC17A5, ABCB7
8fatty liver disease30.5ABCB7, GPT, SLC17A5
9hepatitis d30.4IFNA2, GPT
10cholestasis30.4GPT, SLC17A5, ABCB7, F2
11liver cirrhosis30.4SLC17A5, IFNA2, AFP, GPT, ABCB7, F2
12acute pancreatitis30.4SLC17A5, GPT, ABCB7
13autoimmune hepatitis30.2GPT, SLC17A5, CD40LG, FAS, F2, SEPSECS
14autoimmune hemolytic anemia30.2G6PD, CD40LG
15thrombocytopenia30.2IFNA2, ABCB7, SLC17A5, GPT, F2, CD40LG
16cholecystitis30.1GPT
17alcoholic liver cirrhosis30.1AFP, GPT
18siderosis30.1GPT, UROD
19acute liver failure30.1F2, SLC17A5, GPT
20portal hypertension30.1SLC17A5, GPT, F2
21alcoholic hepatitis30.1F2, SLC17A5, GPT
22hepatic encephalopathy30.1GPT, F2, SLC17A5
23vogt-koyanagi-harada disease30.0FASLG, FAS
24scrub typhus30.0GPT, SLC17A5, CD40LG
25cryoglobulinemia30.0SLC17A5, CD40LG, IFNA2
26obesity29.9CISH, ABCB7, GPT, SLC17A5
27fulminant viral hepatitis10.9
28liver disease10.5
29hepatic coma10.5
30cholangiocarcinoma10.4
31intrahepatic cholangiocarcinoma10.4
32tuberculosis10.4
33hepatitis c virus10.4
34hiv/aids10.4
35thyroiditis10.3
36porphyria10.3
37insulin resistance10.3
38endotheliitis10.3
39lichen planus10.2
40bronchitis10.2
41porphyria cutanea tarda10.2
42typhoid fever10.2
43acute orbital inflammation10.2
44hemolytic anemia10.2
45pancreatitis10.2
46blindness10.2
47polyarteritis nodosa10.1IFNA2
48intrahepatic cholestasis10.1
49pure red-cell aplasia10.1
50extrahepatic cholestasis10.1

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Symptoms for Viral Hepatitis

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Drugs & Therapeutics for Viral Hepatitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Genetic Tests for Viral Hepatitis

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Anatomical Context for Viral Hepatitis

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33MalaCards
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MalaCards organs/tissues related to Viral Hepatitis:

33
Liver, Testes, Kidney, Thyroid, T cells, Endothelial, Bone, Nk cells, Heart, Spleen, Monocytes, Pancreas, Breast, Colon, Spinal cord, Brain, Salivary gland

Animal Models for Viral Hepatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Viral Hepatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.7CD40LG, FASLG, FAS, CISH, AFP
2MP:00053857.2F2, ABCB7, G6PD, FAS, FASLG, CD40LG
3MP:00053977.1F2, CISH, G6PD, FAS, FASLG, CD40LG
4MP:00053847.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
5MP:00036317.0F2, ABCB7, G6PD, FAS, FASLG, CD40LG
6MP:00107686.4F2, ABCB7, AFP, G6PD, FAS, FASLG
7MP:00053766.0SLC17A5, F2, ABCB7, AFP, CISH, G6PD

Publications for Viral Hepatitis

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52PubMed
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Articles related to Viral Hepatitis:

(show top 50)    (show all 885)
idTitleAuthorsYear
1
Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis. (24383922)
2014
2
Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology. (24032050)
2013
3
Chronic viral hepatitis is associated with low bone mineral density in HIV-infected patients, ANRS CO 3 Aquitaine Cohort. (23296138)
2013
4
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
5
Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma. (23983238)
2013
6
Aplastic anemia following viral hepatitis. (24201921)
2013
7
A practical scoring system for predicting cirrhosis in patients with chronic viral hepatitis. (23178625)
2012
8
Maternal and perinatal outcome in cases of fulminant viral hepatitis in late pregnancy. (22947378)
2012
9
The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil. (23270376)
2012
10
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
11
Hematologic and biochemical indices and viral hepatitis in liver transplant patients. (21440777)
2011
12
Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis. (21883739)
2011
13
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
14
Reactivation of viral hepatitis in immunosuppressed patients: an ounce of prevention is worth a pound of cure. (21093439)
2011
15
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
16
Establishment of a viral hepatitis surveillance system--Pakistan, 2009-2011. (21993343)
2011
17
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
18
Assessment of validity of INR system for patients with liver disease associated with viral hepatitis. (19915802)
2010
19
At last a global response to viral hepatitis. (21076557)
2010
20
Determination of the relationship of serum hyaluronic Acid levels to the degree of liver fibrosis in biopsies of patients with chronic viral hepatitis B and C. (22308134)
2010
21
Advances in viral hepatitis: 50 years of Australian gastroenterology. (19799691)
2009
22
Viral hepatitis in solid organ transplant recipients. (20070671)
2009
23
HIV/viral hepatitis coinfection: the Immunology Center experience. (19685638)
2009
24
Vascular and glomerular manifestations of viral hepatitis B and C: a review. (19891305)
2009
25
Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. (18795698)
2008
26
HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in the Czech population. (17573946)
2007
27
Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. (17192324)
2007
28
Relationship of CT manifestations of chronic viral hepatitis with severity of illness]. (15760552)
2005
29
Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases. (16226105)
2005
30
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
31
Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C. (15232637)
2004
32
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
33
Influence of plasma exchange on serum cytokines in severe viral hepatitis patients]. (12857473)
2003
34
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
35
Apoptosis in viral hepatitis B and C. (11480324)
2001
36
Surveillance for hepatocellular carcinoma in patients with chronic viral hepatitis in the United States of America. (11350553)
2001
37
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. (11355694)
2001
38
Changes in the levels of acute phase proteins in viral hepatitis]. (11270948)
2000
39
Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? (11054721)
2000
40
Albumin gradient and portal vein velocity in severe viral hepatitis patients complicated with ascites. (11149035)
2000
41
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999
42
Host factors in chronic viral hepatitis. (9408970)
1997
43
The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. (8871871)
1996
44
Relation between treatment efficacy and cumulative dose of alpha interferon in chronic hepatitis B. European Concerted Action on Viral Hepatitis (Eurohep). (9007705)
1996
45
Interferon and cyclosporin A in the treatment of fulminant viral hepatitis. (7719417)
1995
46
Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis. (1907761)
1991
47
Measurement of serum alcohol dehydrogenase activity at different pH-values during the course of viral hepatitis in children. (2230670)
1990
48
Antibodies to hepatitis C virus in non-A non-B fulminant viral hepatitis. (2112102)
1990
49
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon. (3897068)
1985
50
Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor. (6402856)
1983

Variations for Viral Hepatitis

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Expression for genes affiliated with Viral Hepatitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

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50PathCards, 30KEGG, 55Reactome, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 5Cell Signaling Technology, 57SinoBiological, 53QIAGEN
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Pathways related to Viral Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FASLG, FAS
2
Show member pathways
9.3FASLG, FAS
3
Show member pathways
9.3FAS, FASLG
4
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IFNA2, FASLG, FAS
5
Show member pathways
Immune response CD16 signaling in NK cells60
9.0IFNA2, FASLG, FAS
68.9FASLG, FAS, CISH
7
Show member pathways
8.5FAS, FASLG, CD40LG
8
Show member pathways
8.2CD40LG, IFNA2, FASLG, FAS
9
Show member pathways
8.0F2, FAS, FASLG, IFNA2, CD40LG

Compounds for genes affiliated with Viral Hepatitis

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 3BitterDB, 24HMDB, 61Tocris Bioscience
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Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1hepaplastin4510.0F2, GPT, SLC17A5
2adefovir459.8GPT, IFNA2, SLC17A5
3aminopyrine459.8F2, SLC17A5, GPT
4lamivudine45 51 1111.7F2, GPT, IFNA2, SLC17A5
5silymarin459.5SLC17A5, GPT, F2, ABCB7
6nevirapine45 51 1111.4GPT, SLC17A5, ABCB7
7gamma globulin459.3IFNA2, CD40LG, SLC17A5
8phenobarbital45 29 51 1112.2SLC17A5, GPT, G6PD, UROD
9acetaminophen45 3 51 24 1113.2GPT, F2, G6PD, SLC17A5, AFP
10azathioprine45 3 51 1112.1AFP, G6PD, IFNA2, GPT
11simvastatin45 51 61 29 24 1114.1AFP, FASLG, GPT, F2, SLC17A5
12vitamin-e459.1GPT, G6PD, IFNA2, SLC17A5, ABCB7
13methotrexate51 45 1111.0SLC17A5, FASLG, GPT, F2, AFP
14neopterin459.0SLC17A5, CD40LG, IFNA2, GPT
15uric acid45 2410.0SLC17A5, ABCB7, GPT, G6PD, AFP
16ifn-alpha458.8CISH, FASLG, IFNA2, FAS, GPT
17mitomycin c458.7IFNA2, AFP, FAS, FASLG
18vitamin b12458.7SLC17A5, GPT, AFP, G6PD, CD40LG
19hyaluronic acid45 249.6FASLG, F2, CD40LG, GPT, SLC17A5
20thalidomide45 51 61 1111.6FASLG, AFP, IFNA2, CD40LG
21ethanol45 51 24 1111.5FASLG, ABCB7, GPT, AFP, UROD, SLC17A5
22vitamin a45 24 1110.5FAS, SLC17A5, CD40LG, IFNA2, GPT
23ursodeoxycholic acid45 24 1110.5CD40LG, IFNA2, ABCB7, F2, SLC17A5, GPT
24ribavirin45 51 1110.4GPT, SLC17A5, G6PD, IFNA2, CD40LG, AFP
25polyethylene glycol458.4IFNA2, F2, AFP, SLC17A5, G6PD, CD40LG
26tamoxifen45 51 29 1111.4FASLG, F2, G6PD, SLC17A5, FAS, IFNA2
27ivig458.4GPT, SEPSECS, FAS, FASLG, CD40LG
28fibrinogen458.3SLC17A5, CD40LG, AFP, GPT, F2, ABCB7
29iron45 249.3IFNA2, SLC17A5, UROD, ABCB7, GPT, AFP
30phosphatidylserine45 29 1110.1F2, G6PD, FASLG, FAS, CD40LG
31thyroxine45 248.9ABCB7, GPT, AFP, CD40LG, G6PD, SLC17A5
32ascorbic acid45 248.9FASLG, SLC17A5, IFNA2, FAS, CD40LG, G6PD
33oxygen45 248.8IFNA2, ABCB7, AFP, G6PD, FAS, SLC17A5
34agar457.8FASLG, AFP, G6PD, FAS, CD40LG, IFNA2
35cyclosporin a45 29 619.8GPT, SEPSECS, F2, FAS, FASLG, CD40LG
36lipid457.8ABCB7, SLC17A5, IFNA2, G6PD, CISH, AFP
37doxorubicin45 51 119.7AFP, CD40LG, G6PD, IFNA2, FASLG, FAS
38glucose457.7FASLG, G6PD, IFNA2, SLC17A5, AFP, ABCB7
39n acetylcysteine457.7GPT, FAS, F2, SLC17A5, G6PD, CD40LG
40alanine457.5CD40LG, FASLG, AFP, GPT, ABCB7, F2
41cisplatin45 51 61 1110.5SLC17A5, CD40LG, FASLG, AFP, G6PD, FAS
42heparin45 29 24 1110.4FASLG, CD40LG, F2, ABCB7, FAS, AFP
43estrogen457.4F2, CD40LG, UROD, AFP, CISH, G6PD
44actinomycin d457.4FASLG, CD40LG, FAS, AFP, G6PD
45creatinine457.3CD40LG, ABCB7, F2, SLC17A5, GPT, AFP
46epinephrine45 24 119.3AFP, F2, FAS, IFNA2, CD40LG, SLC17A5
47testosterone45 61 24 1110.2FASLG, FAS, G6PD, AFP, ABCB7, CD40LG
48serine456.9F2, FAS, AFP, CISH, FASLG, CD40LG
49lactate456.8F2, GPT, AFP, G6PD, FAS, ABCB7
50aspartate456.5CD40LG, SLC17A5, IFNA2, FASLG, AFP, G6PD

GO Terms for genes affiliated with Viral Hepatitis

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16Gene Ontology
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Cellular components related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CD40LG, FASLG, FAS
2extracellular spaceGO:0056157.9CD40LG, IFNA2, FASLG, AFP, F2

Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.4FASLG, FAS
2necroptotic signaling pathwayGO:0975279.4FASLG, FAS
3extrinsic apoptotic signaling pathwayGO:0971919.3FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.2FAS, FASLG
5positive regulation of endothelial cell apoptotic processGO:20003539.1CD40LG, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.0FASLG, FAS

Molecular functions related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1CD40LG, FASLG
2cytokine activityGO:0051258.5CD40LG, IFNA2, FASLG

Products for genes affiliated with Viral Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Viral Hepatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet