MCID: VRL010
MIFTS: 57

Viral Hepatitis malady

Infectious category

Summaries for Viral Hepatitis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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CDC:3 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis c and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are Allograft rejection and Toll-like receptor signaling pathway. The compounds alanine and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:64 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

viral hepatitis 8 10 45 61
unspecified viral hepatitis with hepatic coma 8
viral hepatitis with hepatic coma 8
hepatitis, viral, animal 61
hepatitis, viral, human 61
animal viral hepatitis 8
human viral hepatitis 8


External Ids:

Disease Ontology8 DOID:1884
MeSH35 D006524

Related Diseases for Viral Hepatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hepatitis c family:

hepatitis e hepatitis b
autoimmune hepatitis hepatitis d
hepatitis a hepatitis
viral hepatitis hepatitis c virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c32.0IFNA2, IFNA1, PTMA, GGT1, SLC17A5, F2
2hepatitis a31.9F2
3hepatitis d31.7GPT, IFNA1, IFNA2
4hepatitis e31.7GPT, CD40LG
5hepatitis b31.5IFNA2, IFNA1, AFP, HFE, FGL2, GPT
6alcoholic hepatitis30.6GGT1, SLC17A5, F2, GPT
7autoimmune hepatitis30.6SEPSECS
8tuberculosis30.5AKR1A1
9alcohol abuse30.4AKR1A1, HFE, GPT, ABCB7, SLC17A5, GGT1
10insulin resistance30.4SLC17A5, GGT1, HFE, CISH, GPT
11fatty liver disease30.4HFE, GPT, ABCB7, SLC17A5, GGT1
12thrombocytopenia30.3HFE, CD40LG, GPT, IFNA1, IFNA2, ABCB7
13acute pancreatitis30.3ABCB7, SLC17A5, GPT
14porphyria cutanea tarda30.3HFE, UROD
15lichen planus30.3IFNA2
16viral infectious disease30.1GGT1, PTMA, TMPO, SLC17A5, IFNA1, FASLG
17thalassemia30.1HFE, G6PD
18acute liver failure30.1SLC17A5, F2, GPT
19autoimmune hemolytic anemia30.1G6PD, CD40LG
20vitiligo30.1G6PD
21cryoglobulinemia29.9IFNA2, SLC17A5, CD40LG, IFNA1
22portal hypertension29.9SLC17A5, GPT, F2, GGT1
23thyroiditis29.9FASLG, IFNA1
24arthritis29.9HFE, CISH
25scrub typhus29.9CD40LG, GPT, SLC17A5
26siderosis29.9HFE, UROD, GPT
27hemochromatosis29.9HFE, UROD
28alcoholic liver cirrhosis29.9AFP, GPT
29vogt-koyanagi-harada disease29.9FASLG, FAS
30fulminant viral hepatitis10.9
31hepatitis c virus10.5
32hepatic coma10.5
33typhoid fever10.3
34non-a-e hepatitis10.2
35intrahepatic cholestasis10.1
36extrahepatic cholestasis10.1
37pernicious anemia10.1
38dubin-johnson syndrome10.1
39aplastic anemia10.1
40guillain-barr� syndrome10.1
41hepatocellular carcinoma10.0UROD, AKR1A1, CISH, AFP, HFE, GPT
42liver cirrhosis10.0F2, PTMA, GGT1, SLC17A5, ABCB7, GPT
43congenital generalized lipodystrophy type 310.0SEPSECS, PTMA, GGT1, SLC17A5, ABCB7, GPT
44leukemia10.0IFNA1, HFE, CD40LG, FAS, TMPO, CISH
45leukopenia10.0SLC17A5, TMPO, GPT, IFNA1, IFNA2, F2
46deficiency anemia10.0ABCB7, G6PD, HFE, IFNA1, IFNA2, TMPO
47ipex syndrome10.0FAS, PTMA, ABCB7, GPT, CD40LG, TMPO
48melanoma10.0TMPO, IFNA2, IFNA1, FAS, FASLG, CISH
49galactosemia10.0F2, AFP, GPT, SLC17A5, GGT1, ABCB7
50primary biliary cirrhosis10.0GPT, F2, SLC17A5, GGT1, CD40LG, SEPSECS

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Clinical Features for Viral Hepatitis

Drugs & Therapeutics for Viral Hepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Viral Hepatitis

Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Search CenterWatch for Viral Hepatitis

Genetic Tests for Viral Hepatitis

Anatomical Context for Viral Hepatitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Viral Hepatitis:

33
Liver, Spinal cord, Brain, Kidney, Lymph node, Spleen, Heart, Colon, Pancreas, Thyroid, Salivary gland, Breast, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Viral Hepatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Viral Hepatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8FAS, GGT1, SLC17A5, F2, ABCB7, FGL2
2MP:000539710.8GGT1, FAS, FASLG, G6PD, AKR1A1, TMPO
3MP:001076810.6GGT1, UROD, AKR1A1, FASLG, FAS, AFP

Publications for Viral Hepatitis

Sources:
51PubMed
See all sources

Articles related to Viral Hepatitis:

(show top 50)    (show all 1355)
idTitleAuthorsYear
1
Program Collaboration and Service Integration in the Prevention and Control of HIV Infection, Viral Hepatitis, STDs, and Tuberculosis in the U.S.: Lessons Learned from the Field. (24385642)
2014
2
Treatment of children with chronic viral hepatitis: what is available and what is in store. (23929253)
2013
3
Integrating a social determinants of health approach into public health practice: a five-year perspective of actions implemented by CDC's national center for HIV/AIDS, viral hepatitis, STD, and TB prevention. (24179273)
2013
4
A Better Quality of Life in Hemodialysis Patients With Viral Hepatitis: Is it a Reality? (24348649)
2013
5
Hepatocyte Growth Factor Dampens Liver Immune-Mediated Pathology in Acute Viral Hepatitis without Compromising Antiviral Activity. (24224701)
2013
6
Viral determinants predicting hepatitis B surface antigen (HBsAg) seroclearance in HIV-/HBV-coinfected patients. (24112778)
2013
7
Portal vein thrombosis during eltrombopag treatment for immune thrombocytopenic purpura in a patient with liver cirrhosis due to hepatitis C viral infection. (23995112)
2013
8
Diagnostic significance of hepatitis B viral antigens in patients with glomerulonephritis-associated hepatitis B virus infection. (22248736)
2012
9
Viral hepatitis and HIV infection among injection drug users in a central Iranian City. (22895463)
2012
10
Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C. (22530132)
2012
11
Raising awareness of viral hepatitis: National Hepatitis Testing Day, May 19. (22547853)
2012
12
Viral hepatitis in the elderly. (22290404)
2012
13
Update on alisporivir in treatment of viral hepatitis C. (22316207)
2012
14
Association of interleukin-28B and hepatitis C genotype 1 with a high viral load and response to pegylated interferon plus ribavirin therapy. (22156487)
2011
15
Viral hepatitis in renal transplantation. (21722603)
2011
16
Intravenous Drug Users Can Achieve a High Sustained Virological Response Rate: experience From Croatian Reference Center for Viral Hepatitis. (22368683)
2011
17
Milestones and perspectives in viral hepatitis B. (21205150)
2011
18
miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. (21725618)
2011
19
Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly. (21653755)
2011
20
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. (21849455)
2011
21
Hepatitis C virus recurrence after liver transplantation: analysis of factors related to sustained viral response. (20304219)
2010
22
Non-viral-related pathologic findings in liver needle biopsy specimens from patients with chronic viral hepatitis. (20551282)
2010
23
Viral hepatitis in solid organ transplant recipients. (20070671)
2009
24
Spinal cord biopsy findings of anti-aquaporin-4 antibody-negative recurrent longitudinal myelitis in a patient with sicca symptoms and hepatitis C viral infection. (18992010)
2009
25
Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. (18795698)
2008
26
ALT and viral load decline during PEG-IFN alpha-2b treatment for HBeAg-positive chronic hepatitis B. (18359663)
2008
27
Imbalance between expression of endothelin receptors A and B in terminal liver cirrhosis due to hepatitis C viral infection: immunohistochemical study of autopsy cases. (17565586)
2008
28
Efficacy and anticarcinogenic activity of interferon for hepatitis C virus-related compensated cirrhosis in patients with genotype 1b low viral load or genotype 2. (17593231)
2007
29
The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection. (17560677)
2007
30
Interferon therapy improves the irregular regeneration of hepatocytes in liver in patients with C-viral chronic hepatitis and liver cirrhosis. (17191016)
2007
31
Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C. (16094713)
2005
32
Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C. (15232637)
2004
33
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51. (15000871)
2004
34
Similar increased serum dipeptidyl peptidase IV activity in chronic hepatitis C and other viral infections. (12727530)
2003
35
Interferon-stimulated gene expression and hepatitis C viral dynamics during different interferon regimens. (12927929)
2003
36
Comparison of etiology of sporadic acute and fulminant viral hepatitis in hospitalized patients in Pune, India during 1978-81 and 1994-97. (12617445)
2003
37
Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. (14707465)
2003
38
Insulin autoimmune syndrome in a patient with viral hepatitis C. (12201836)
2002
39
Transcriptional repression of the human p53 gene by hepatitis B viral X protein. (10656696)
2000
40
Impact of decreased serum transaminase levels on the evaluation of viral hepatitis in hemodialysis patients. (7777113)
1995
41
Interleukin-8 and granulocyte-macrophage colony-stimulating factor secretion in hepatocellular carcinoma and viral chronic active hepatitis. (7859412)
1995
42
Alanine aminotransferase--a surrogate marker of viral hepatitis]. (7740784)
1995
43
Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: results from a controlled randomized trial in 80 patients. (7843700)
1995
44
IFN in the treatment of chronic viral hepatitis. Efficacy and tolerance of lymphoblastoid alpha interferon in HIV-negative drug addicts and associated chronic active hepatitis C]. (7534222)
1994
45
Autoantibodies in viral hepatitis-related hepatocellular carcinoma. (8407252)
1993
46
Decrease of haptoglobin serum level in patients with chronic viral hepatitis C]. (8349072)
1993
47
Histologic changes in liver biopsy specimens produced by recombinant interferon alpha-2b therapy for chronic non-A,non-B viral hepatitis. A randomized controlled trial. (1415021)
1992
48
Safety and efficacy of interferon alpha-2b following prednisone withdrawal in the treatment of chronic viral hepatitis B. A case-controlled, randomised study. (1448711)
1992
49
Tumour necrotic factor (TNF) in the pathogenesis of liver necrosis in viral hepatitis and strategy for its prevention and treatment]. (2174282)
1990
50
Acute inflammatory polyradiculoneuropathy following type A viral hepatitis. (7335565)
1981

Genetic Variations for Viral Hepatitis

Expression for genes affiliated with Viral Hepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome
See all sources

Compounds for genes affiliated with Viral Hepatitis

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1alanine4511.4PTMA, IFNA1, SLC17A5, F2, ABCB7, IFNA2
2aspartate4511.3AFP, TMPO, SLC17A5, F2, ABCB7, GPT
3lactate4511.3ABCB7, FAS, FASLG, GGT1, SLC17A5, G6PD
4cisplatin45 50 60 1114.3AFP, IFNA1, FAS, IFNA2, CD40LG, SLC17A5
5ribavirin45 50 1113.3GPT, CD40LG, G6PD, IFNA1, IFNA2, SLC17A5
6n acetylcysteine4511.2F2, FAS, G6PD, CD40LG, GPT, AKR1A1
7ethanol45 50 11 2414.2GGT1, SLC17A5, HFE, FASLG, ABCB7, GPT
8ursodeoxycholic acid45 11 2413.2F2, GGT1, SLC17A5, ABCB7, GPT, CD40LG
9cyclosporin a45 29 6013.2IFNA1, FAS, FASLG, TMPO, GPT, CD40LG
10thyroxine45 2412.2CD40LG, GGT1, SLC17A5, ABCB7, GPT, IFNA2
11iron45 2412.2HFE, IFNA2, ABCB7, GPT, GGT1, SLC17A5
12creatinine4511.2SLC17A5, FAS, GGT1, AFP, F2, ABCB7
13epinephrine45 11 2413.2AFP, F2, G6PD, FASLG, FAS, CD40LG
14ifn-alpha4511.2GPT, CISH, FASLG, FAS, IFNA1, IFNA2
15ascorbic acid45 2412.2CD40LG, HFE, GGT1, IFNA2, G6PD, FASLG
16polyethylene glycol4511.2CD40LG, IFNA1, SLC17A5, IFNA2, G6PD, AFP
17doxorubicin45 50 1113.1AFP, AKR1A1, FASLG, CD40LG, IFNA1, IFNA2
18testosterone45 60 11 2414.1HFE, ABCB7, CD40LG, SLC17A5, GGT1, G6PD
19vitamin b124511.1GPT, SLC17A5, CD40LG, GGT1, AFP, G6PD
20adefovir4511.1SLC17A5, IFNA2, GPT, PTMA, IFNA1
21phenobarbital45 29 1113.1G6PD, AKR1A1, UROD, GPT, SLC17A5, GGT1
22nash4511.0GPT, SLC17A5, AKR1A1, HFE, GGT1
23uric acid45 2412.0ABCB7, HFE, AFP, G6PD
24vitamin-e4511.0SLC17A5, GGT1, GPT, G6PD, IFNA2, ABCB7
25zidovudine45 1112.0TMPO, PTMA, SLC17A5, GPT, IFNA2, IFNA1
26tamoxifen45 50 29 1114.0SLC17A5, FASLG, IFNA1, G6PD, GGT1
27glucose4511.0SLC17A5, CISH, FASLG, IFNA2, TMPO
28entecavir4511.0GPT, IFNA1, PTMA, IFNA2
29lamivudine45 1112.0PTMA, SLC17A5, F2
30serine4511.0FGL2, AFP, SEPSECS, G6PD, AKR1A1, CISH
31agar4511.0AFP, FASLG, FAS, G6PD, PTMA
32acetaminophen45 2 50 11 2415.0SLC17A5, GGT1, GPT
33silymarin4510.9GPT, ABCB7, F2, SLC17A5, GGT1
34mycophenolate mofetil45 50 1112.9GGT1, GPT, IFNA1, SEPSECS, CD40LG
35aminopyrine4510.9GGT1, SLC17A5, F2, GPT
36fibrinogen4510.9AFP, CD40LG, FGL2, GPT, ABCB7, F2
37vitamin a45 11 2412.9IFNA2, FAS, AKR1A1
38estrogen4510.9UROD
39heparin45 29 11 2413.9FAS, FASLG, AFP, ABCB7, CD40LG
40amantadine45 1111.9IFNA2, IFNA1, PTMA, GPT
41gamma globulin4510.9GGT1, IFNA2
42cyclophosphamide45 50 1112.8AFP, FASLG, IFNA1, IFNA2, PTMA, G6PD
43indomethacin45 60 29 1113.8TMPO, AKR1A1, GGT1
44hyaluronic acid45 2411.8CD40LG, GGT1, SLC17A5, F2, FASLG, GPT
45ivig4510.8CD40LG, SEPSECS, GPT
46lipid4510.7GGT1, SLC17A5, ABCB7, GPT, HFE, CISH
47neopterin4510.7CD40LG, IFNA1, GPT, SLC17A5, IFNA2
48thalidomide45 50 60 1113.7CD40LG, FASLG, IFNA2, IFNA1, AFP
49nevirapine45 50 1112.6GGT1, SLC17A5, ABCB7, GPT
505-hydroxytryptophol4510.3GPT, SLC17A5, AKR1A1

GO Terms for genes affiliated with Viral Hepatitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.5FASLG, FAS
2inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
3positive regulation of endothelial cell apoptotic processGO:200035310.2CD40LG, FASLG

Products for genes affiliated with Viral Hepatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Viral Hepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet