MCID: VRL010
MIFTS: 61

Viral Hepatitis malady

Infectious diseases category

Summaries for Viral Hepatitis

About this section
Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 "Hepatitis" means inflammation of the liver and also refers to a group of viral infections that affect the liver . The most common types are Hepatitis A, Hepatitis B, and Hepatitis C.

MalaCards: Viral Hepatitis, also known as unspecified viral hepatitis with hepatic coma, is related to hepatitis and hepatitis a. An important gene associated with Viral Hepatitis is GPT (glutamic-pyruvate transaminase (alanine aminotransferase)), and among its related pathways are Allograft rejection and Toll-like receptor signaling pathway. The compounds alanine and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A hepatitis that involves viral infection causing inflammation of the liver.

Wikipedia:63 Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent... more...

Aliases & Classifications for Viral Hepatitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

viral hepatitis 8 10 44 60
unspecified viral hepatitis with hepatic coma 8
viral hepatitis with hepatic coma 8
hepatitis, viral, animal 60
hepatitis, viral, human 60
animal viral hepatitis 8
human viral hepatitis 8


External Ids:

Disease Ontology8 DOID:1884
MeSH34 D006524

Related Diseases for Viral Hepatitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a Hepatitis
viral hepatitis Hepatitis C Virus

Diseases related to Viral Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.1IFNA1, GPT, SLC17A5
2hepatitis a31.7F2
3hepatitis c31.5HFE, CD40LG, GPT, ABCB7, F2, SLC17A5
4hepatitis b31.5ABCB7, F2, SLC17A5, GGT1, PTMA, TMPO
5hepatocellular carcinoma31.1CISH, AFP, HFE, GPT, ABCB7, F2
6hepatitis e31.0CD40LG, GPT
7alcoholic hepatitis30.8GPT, F2, SLC17A5, GGT1
8autoimmune hepatitis30.7SEPSECS
9cholangiocarcinoma30.6GGT1, AFP
10liver cirrhosis30.5SEPSECS, PTMA, IFNA2, IFNA1, AKR1A1, CISH
11tuberculosis30.5AKR1A1
12thyroiditis30.4FASLG, IFNA1
13alcohol abuse30.3AKR1A1, HFE, GPT, ABCB7, SLC17A5, GGT1
14cholestasis30.3GPT, ABCB7, F2, SLC17A5, GGT1
15fatty liver disease30.3HFE, GPT, ABCB7, SLC17A5, GGT1
16porphyria30.3HFE, UROD
17hepatitis d30.3IFNA2, IFNA1, GPT
18thrombocytopenia30.2IFNA2, IFNA1, HFE, CD40LG, GPT, ABCB7
19acute pancreatitis30.2SLC17A5, ABCB7, GPT
20pancreatitis30.2SLC17A5, GGT1
21porphyria cutanea tarda30.2HFE, UROD
22lichen planus30.2IFNA2
23hemolytic anemia30.2IFNA2, G6PD, HFE
24viral infectious disease30.1IFNA2, IFNA1, FAS, FASLG, UROD, G6PD
25diabetes mellitus30.1G6PD, HFE, CD40LG, GPT, GGT1
26hypertension30.1GGT1, F2
27herpes simplex30.1TMPO, IFNA1
28malaria30.1G6PD
29acute liver failure30.1GPT, F2, SLC17A5
30influenza30.1TMPO, IFNA1
31autoimmune hemolytic anemia30.1CD40LG, G6PD
32alcohol dependence30.1GGT1
33vitiligo30.1G6PD
34breast cancer29.9FAS, G6PD, AKR1A1, CISH, PTMA, TMPO
35obesity29.9CISH, HFE, GPT, ABCB7, SLC17A5, GGT1
36cryoglobulinemia29.9IFNA2, IFNA1, CD40LG, SLC17A5
37portal hypertension29.9GPT, F2, SLC17A5, GGT1
38multiple sclerosis29.9IFNA1, FASLG, TMPO
39peritonitis29.9F2
40arthritis29.9HFE, CISH
41schistosomiasis29.9CD40LG
42scrub typhus29.9CD40LG, GPT, SLC17A5
43siderosis29.9UROD, HFE, GPT
44colon cancer29.9FASLG, FAS
45hemochromatosis29.9HFE, UROD
46hepatic encephalopathy29.9GPT, F2, SLC17A5
47cholecystitis29.9GPT
48alcoholic liver cirrhosis29.9AFP, GPT
49vogt-koyanagi-harada disease29.9FASLG, FAS
50glomerulonephritis29.9CD40LG

Graphical network of the top 20 diseases related to Viral Hepatitis:



Diseases related to viral hepatitis

Clinical Features for Viral Hepatitis

About this section

Drugs & Therapeutics for Viral Hepatitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Viral Hepatitis

Drug clinical trials:

Search ClinicalTrials for Viral Hepatitis

Search NIH Clinical Center for Viral Hepatitis

Search CenterWatch for Viral Hepatitis

Genetic Tests for Viral Hepatitis

About this section

Anatomical Context for Viral Hepatitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Viral Hepatitis:

32
Liver, Kidney, Testes, T cells, Thyroid, Endothelial, Nk cells, Bone, Monocytes, Spinal cord, Heart, Spleen, Salivary gland, Pancreas, Colon, Lymph node, B cells, Breast, Brain

Animal Models for Viral Hepatitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Viral Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8FAS, GGT1, SLC17A5, F2, ABCB7, FGL2
2MP:000539710.8GGT1, FAS, FASLG, G6PD, AKR1A1, TMPO
3MP:001076810.6GGT1, UROD, AKR1A1, FASLG, FAS, AFP

Publications for Viral Hepatitis

About this section
Sources:
50PubMed
See all sources

Articles related to Viral Hepatitis:

(show top 50)    (show all 1368)
idTitleAuthorsYear
1
Treatment of children with chronic viral hepatitis: what is available and what is in store. (23929253)
2013
2
Integrating a social determinants of health approach into public health practice: a five-year perspective of actions implemented by CDC's national center for HIV/AIDS, viral hepatitis, STD, and TB prevention. (24179273)
2013
3
Association of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication. (24341744)
2013
4
HLA-DP and interferon gamma receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection. (23980639)
2013
5
A practical scoring system for predicting cirrhosis in patients with chronic viral hepatitis. (23178625)
2012
6
Levels of malondialdehyde, myeloperoxidase and nitrotyrosine in patients with chronic viral hepatitis B and C. (23214299)
2012
7
Viral hepatitis in the elderly. (22290404)
2012
8
HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypes. (22190394)
2012
9
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
10
Treatment of chronic hepatitis C in Croatian war veterans: experiences from Croatian reference center for viral hepatitis. (21328718)
2011
11
Anti-hepatitis A seroprevalence among chronic viral hepatitis patients in Kelantan, Malaysia. (22039329)
2011
12
Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly. (21653755)
2011
13
Assessment of the seroprevalence of viral hepatitis B, viral hepatitis C and HIV in multitransfused thalassaemia major patients in Karachi, Pakistan. (20940290)
2011
14
Etiology-related determinants of liver stiffness values in chronic viral hepatitis B or C. (21146243)
2011
15
Polymorphisms of toll-like receptors and their pathways in viral hepatitis. (21685532)
2011
16
High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. (21145845)
2011
17
Ascitic form of sporadic acute viral hepatitis in children: a distinct entity for recognition. (19966578)
2010
18
The incidence and significance of pattern-recognition receptors in chronic viral hepatitis types B and C in man. (20533094)
2010
19
Steatosis and serum lipid patterns in patients with chronic viral hepatitis: differences related to viral etiology. (20809028)
2010
20
Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. (20036646)
2010
21
Clinical outcomes in adults with chronic hepatitis B in association with patient and viral characteristics: A systematic review of evidence. (19399797)
2009
22
Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis. (17553719)
2008
23
Efficacy and anticarcinogenic activity of interferon for hepatitis C virus-related compensated cirrhosis in patients with genotype 1b low viral load or genotype 2. (17593231)
2007
24
Leptin receptor isoforms mRNA expression in peripheral blood mononuclear cells from patients with chronic viral hepatitis. (17060687)
2006
25
Curative effects of interferon-alpha and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B. (15237447)
2004
26
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication. (15326295)
2004
27
Sustained response with negative serum HCV-mRNA and disappearance of antibodies after interferon-alpha therapy in a kidney transplant recipient with chronic active viral hepatitis C. (12832744)
2003
28
Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis. (12809841)
2003
29
An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis. (12033786)
2002
30
Soluble thrombomodulin is associated with viral hepatitis, blood pressure, and medications in haemodialysis patients. (11274275)
2001
31
HLA class II genes determine the natural variance of hepatitis C viral load. (11124840)
2001
32
Transcriptional repression of the human p53 gene by hepatitis B viral X protein. (10656696)
2000
33
Chronic viral hepatitis in renal transplant recipients with allografts functioning for more than 20 years. (10075593)
1999
34
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. (9756471)
1998
35
Kidney transplantation in a child with posterior urethral valve from a hepatitis B virus-carrier mother. Report of a case with special reference to urinary tract reconstruction for dysfunctionalized uropathies and seroimmunological preparation against viral transmission. (10364757)
1998
36
Hepatitis C virus infection detected by viral RNA analysis in porphyria cutanea tarda. (9120326)
1997
37
Interferon therapy for acute hepatitis C viral infection--a review by meta-analysis. (9404604)
1997
38
Serine protease inhibitors in patients with chronic viral hepatitis. (9252072)
1997
39
Interleukin-8 and granulocyte-macrophage colony-stimulating factor secretion in hepatocellular carcinoma and viral chronic active hepatitis. (7859412)
1995
40
Alanine aminotransferase--a surrogate marker of viral hepatitis]. (7740784)
1995
41
Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: results from a controlled randomized trial in 80 patients. (7843700)
1995
42
Autoantibodies in viral hepatitis-related hepatocellular carcinoma. (8407252)
1993
43
Correction of disorders in the monooxygenase system function with diethylnicotinamide (cordiamine) in tetrachloromethane- induced and viral hepatitis]. (8279144)
1993
44
Sex hormones and sex hormone-binding globulin in males with chronic viral hepatitis during recombinant interferon-alpha 2b therapy. (8366286)
1993
45
The tocopherol acetate and splenin correction of the immunological disorders in patients with viral hepatitis B]. (1441392)
1992
46
The importance of the antioxidant protection systems of the blood in adaptation to the infectious process in viral hepatitis B]. (1810063)
1991
47
Tumour necrotic factor (TNF) in the pathogenesis of liver necrosis in viral hepatitis and strategy for its prevention and treatment]. (2174282)
1990
48
Fulminant viral hepatitis. (6994949)
1980
49
Exchange transfusion and corticosteroids in the treatment of acute viral hepatitis hepatic coma. (1223069)
1975
50
Hepatic coma associated with acute viral hepatitis; recovery with ACTH; report of one case. (13669293)
1959

Genetic Variations for Viral Hepatitis

About this section

Expression for genes affiliated with Viral Hepatitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Viral Hepatitis

Search GEO for disease gene expression data for Viral Hepatitis.

Pathways for genes affiliated with Viral Hepatitis

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome
See all sources

Compounds for genes affiliated with Viral Hepatitis

About this section
Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Viral Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1alanine4411.4AFP, AKR1A1, FASLG, IFNA1, IFNA2, HFE
2aspartate4411.3TMPO, SLC17A5, F2, ABCB7, GPT, CD40LG
3lactate4411.3FAS, FASLG, G6PD, AKR1A1, AFP, CD40LG
4cisplatin44 49 59 1114.3IFNA2, IFNA1, FAS, FASLG, G6PD, AFP
5ribavirin44 49 1113.3AFP, G6PD, IFNA1, IFNA2, CD40LG, GPT
6n acetylcysteine4411.2FAS, FASLG, G6PD, AKR1A1, CD40LG, GPT
7ethanol44 49 11 2414.2FASLG, UROD, AKR1A1, AFP, HFE, GPT
8ursodeoxycholic acid44 11 2413.2GGT1, SLC17A5, F2, ABCB7, GPT, CD40LG
9cyclosporin a44 28 5913.2IFNA1, FAS, FASLG, CD40LG, GPT, F2
10thyroxine44 2412.2IFNA2, G6PD, AFP, CD40LG, GPT, ABCB7
11iron44 2412.2IFNA2, FASLG, UROD, AFP, HFE, GPT
12creatinine4411.2FAS, AKR1A1, AFP, GPT, ABCB7, F2
13epinephrine44 11 2413.2IFNA2, FAS, FASLG, G6PD, AFP, CD40LG
14ifn-alpha4411.2IFNA2, IFNA1, FAS, FASLG, CISH, GPT
15ascorbic acid44 2412.2IFNA2, FAS, FASLG, G6PD, HFE, CD40LG
16polyethylene glycol4411.2IFNA2, IFNA1, G6PD, AFP, CD40LG, F2
17doxorubicin44 49 1113.1IFNA2, IFNA1, FAS, FASLG, G6PD, AKR1A1
18testosterone44 59 11 2414.1FAS, FASLG, G6PD, AFP, HFE, CD40LG
19vitamin b124411.1G6PD, AFP, CD40LG, GPT, SLC17A5, GGT1
20adefovir4411.1IFNA2, IFNA1, GPT, SLC17A5, PTMA
21phenobarbital44 28 1113.1UROD, G6PD, AKR1A1, GPT, SLC17A5, GGT1
22nash4411.0AKR1A1, HFE, GPT, SLC17A5, GGT1
23uric acid44 2412.0G6PD, AFP, HFE, ABCB7
24vitamin-e4411.0IFNA2, G6PD, GPT, ABCB7, SLC17A5, GGT1
25zidovudine44 1112.0IFNA2, IFNA1, GPT, SLC17A5, PTMA, TMPO
26tamoxifen44 49 28 1114.0IFNA1, FASLG, G6PD, SLC17A5, GGT1
27glucose4411.0TMPO, SLC17A5, CISH, FASLG, IFNA2
28entecavir4411.0IFNA2, IFNA1, GPT, PTMA
29lamivudine44 1112.0F2, SLC17A5, PTMA
30serine4411.0SEPSECS, FGL2, AFP, CISH, AKR1A1, G6PD
31agar4411.0FAS, FASLG, G6PD, AFP, PTMA
32acetaminophen44 2 49 11 2415.0GPT, SLC17A5, GGT1
33silymarin4410.9GPT, ABCB7, F2, SLC17A5, GGT1
34mycophenolate mofetil44 49 1112.9SEPSECS, GGT1, GPT, CD40LG, IFNA1
35aminopyrine4410.9GPT, F2, SLC17A5, GGT1
36fibrinogen4410.9ABCB7, GPT, FGL2, CD40LG, AFP, F2
37vitamin a44 11 2412.9IFNA2, FAS, AKR1A1
38estrogen4410.9UROD
39heparin44 28 11 2413.9FAS, FASLG, AFP, CD40LG, ABCB7
40amantadine44 1111.9PTMA, GPT, IFNA1, IFNA2
41gamma globulin4410.9GGT1, IFNA2
42cyclophosphamide44 49 1112.8IFNA2, IFNA1, FASLG, G6PD, AFP, PTMA
43indomethacin44 59 28 1113.8AKR1A1, GGT1, TMPO
44hyaluronic acid44 2411.8FASLG, CD40LG, GPT, F2, SLC17A5, GGT1
45ivig4410.8SEPSECS, GPT, CD40LG
46lipid4410.7IFNA2, G6PD, AKR1A1, CISH, AFP, HFE
47neopterin4410.7IFNA2, IFNA1, CD40LG, GPT, SLC17A5
48thalidomide44 49 59 1113.7CD40LG, AFP, FASLG, IFNA1, IFNA2
49nevirapine44 49 1112.6GPT, ABCB7, SLC17A5, GGT1
505-hydroxytryptophol4410.3AKR1A1, GPT, SLC17A5

GO Terms for genes affiliated with Viral Hepatitis

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Viral Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.5FASLG, FAS
2inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
3positive regulation of endothelial cell apoptotic processGO:200035310.2CD40LG, FASLG

Products for genes affiliated with Viral Hepatitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Viral Hepatitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet