MCID: VRL011
MIFTS: 64

Viral Infectious Disease

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Viral Infectious Disease

Summaries for Viral Infectious Disease

MedlinePlus : 40 Viruses are very tiny germs. They are made of genetic material inside of a protein coating. Viruses cause familiar infectious diseases such as the common cold, flu and warts. They also cause severe illnesses such as HIV/AIDS, smallpox, and Ebola. Viruses are like hijackers. They invade living, normal cells and use those cells to multiply and produce other viruses like themselves. This can kill, damage, or change the cells and make you sick. Different viruses attack certain cells in your body such as your liver, respiratory system, or blood. When you get a virus, you may not always get sick from it. Your immune system may be able to fight it off. For most viral infections, treatments can only help with symptoms while you wait for your immune system to fight off the virus. Antibiotics do not work for viral infections. There are antiviral medicines to treat some viral infections. Vaccines can help prevent you from getting many viral diseases.

MalaCards based summary : Viral Infectious Disease, also known as arbovirus infections, is related to chronic active epstein-barr virus infection and tick-borne encephalitis, and has symptoms including pathological conditions, signs and symptoms, pruritus and fever. An important gene associated with Viral Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ethanol and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and t cells, and related phenotypes are cellular and hematopoietic system

Disease Ontology : 12 A disease by infectious agent that results_in infection, has material basis in Viruses.

CDC : 3 Powassan (POW) virus is transmitted to humans by infected ticks. Approximately 100 cases of POW virus disease were reported in the United States over the past 10 years. Most cases have occurred in the Northeast and Great Lakes region. Signs and symptoms of infection can include fever, headache, vomiting, weakness, confusion, seizures, and memory loss. Long-term neurologic problems may occur. There is no specific treatment, but people with severe POW virus illnesses often need to be hospitalized to receive respiratory support, intravenous fluids, or medications to reduce swelling in the brain.

Wikipedia : 72 A viral disease (or viral infection) occurs when an organism\'s body is invaded by pathogenic viruses,... more...

Related Diseases for Viral Infectious Disease

Diseases related to Viral Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 chronic active epstein-barr virus infection 34.5 IFNG IL10 IL2
2 tick-borne encephalitis 32.5 CCR5 CXCL10 IL10 TLR3
3 zika fever 32.4 CD40LG IFNB1
4 la crosse encephalitis 32.4 CD40LG DDX58 IFNB1 IRF3
5 ross river fever 32.4 CD40LG IL10
6 yellow fever 32.4 CCR5 IFNB1 IRF7 TLR9
7 poliomyelitis 32.3 IFNG IL10 TNF
8 newcastle disease 32.3 DDX58 IFNA1 IFNB1 IRF3
9 kyasanur forest disease 32.3 CD40LG IFNA1
10 progressive multifocal leukoencephalopathy 32.3 CD40LG IL2 TNF
11 hemorrhagic fever with renal syndrome 32.3 CD40LG IL10 TNF
12 mumps 32.3 CD40LG IFNG IL2
13 chikungunya 32.3 CD40LG DDX58 MAVS TNF
14 smallpox 32.3 IFNG IL2 TNF
15 rubella 32.3 CD40LG IL10 TNF
16 tropical spastic paraparesis 32.3 IFNG IL10 IL2
17 hepatitis e 32.3 CD40LG DDX58 IFNG TLR3 TNF
18 herpes zoster 32.3 IFNA2 IFNG IL10 IL2
19 japanese encephalitis 32.2 CXCL10 DDX58 IFNB1 TLR3 TNF
20 rabies 32.2 CD40LG CXCL10 IRF3 MX1 TLR3
21 marburg hemorrhagic fever 32.2 IFNB1 TNF
22 vaccinia 32.2 IFNA1 IFNB1 IL2 IRF3 IRF7
23 hepatitis b 32.1 IFNA1 IFNA2 IFNG TLR3 TNF
24 herpes simplex 32.0 DDX58 IFIH1 IFNA1 IFNB1 IRF3 TLR3
25 severe acute respiratory syndrome 32.0 CD40LG CXCL10 IFNA1 IFNB1 IFNG IRF3
26 measles 31.9 CD40LG DDX58 IFIH1 IFNA1 IFNB1 IFNG
27 influenza 31.8 DDX58 IFNA1 IFNB1 IFNG IRF7 MX1
28 human immunodeficiency virus infectious disease 31.7 CCR5 CD40LG IFNA1 IFNG IL10 IL2
29 hepatitis c 31.5 CXCL10 DDX58 IFNA1 IFNA2 IFNB1 IFNG
30 zika virus infection 12.4
31 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 12.3
32 congenital herpes simplex virus infection 12.1
33 hendra virus infection 12.1
34 primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection 12.1
35 x-linked magnesium deficiency with epstein-barr virus infection and neoplasia 12.0
36 lethal idiopathic viral infection 12.0
37 congenital epstein-barr virus infection 12.0
38 nipah virus disease 12.0
39 simian b virus infection 12.0
40 immunodeficiency 31b 11.8
41 caspase 8 deficiency 11.7
42 lymphocytic choriomeningitis 11.1
43 panencephalitis, subacute sclerosing 10.8
44 dengue disease 10.8
45 powassan encephalitis 10.8
46 argentine hemorrhagic fever 10.8
47 bolivian hemorrhagic fever 10.8
48 venezuelan hemorrhagic fever 10.8
49 brazilian hemorrhagic fever 10.8
50 chapare hemorrhagic fever 10.8

Graphical network of the top 20 diseases related to Viral Infectious Disease:



Diseases related to Viral Infectious Disease

Symptoms & Phenotypes for Viral Infectious Disease

UMLS symptoms related to Viral Infectious Disease:


pathological conditions, signs and symptoms, pruritus, fever

MGI Mouse Phenotypes related to Viral Infectious Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 TLR9 IRF3 TNF ITIH4 TLR7 IL2
2 hematopoietic system MP:0005397 10.24 TLR9 TNF IRF7 MAVS TLR3 TLR7
3 homeostasis/metabolism MP:0005376 10.22 TLR9 IRF3 TNF IRF7 MAVS TLR3
4 immune system MP:0005387 10.16 IRF3 TNF IRF7 MAVS TLR3 TLR7
5 digestive/alimentary MP:0005381 10.01 IL2 TLR9 TNF MAVS IL10 DDX58
6 mortality/aging MP:0010768 9.8 TLR9 IRF7 TNF MAVS TLR3 TLR7
7 liver/biliary system MP:0005370 9.76 IL2 TNF ITIH4 IL10 DDX58 IFIH1
8 neoplasm MP:0002006 9.28 TNF ITIH4 TLR3 IL10 DDX58 IL2

Drugs & Therapeutics for Viral Infectious Disease

Drugs for Viral Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1221)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 64-17-5 702
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
3
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
4
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
5
Heroin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 561-27-3 5462328
6
Ezetimibe Approved Phase 4,Phase 2,Phase 1 163222-33-1 150311
7
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
8
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
9
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 104987-11-3 445643 439492
10
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
11
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
12
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
13
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
14
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
15
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159989-64-7 64143
16
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
17
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5381226 5458213
18
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1 192725-17-0 92727
19
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154598-52-4 64139
20
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
21
Nevirapine Approved Phase 4,Phase 3,Phase 2,Phase 1 129618-40-2 4463
22
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
23
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
24
chloroquine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 54-05-7 2719
25
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 30516-87-1 35370
26
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
27
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
28
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
29
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 134678-17-4 60825
30
Cidofovir Approved Phase 4,Phase 3,Phase 2,Phase 1 113852-37-2 60613
31
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 82410-32-0 3454
32
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
33
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 4091 14219
34
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 69-72-7 338
35
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
36
Formaldehyde Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-00-0 712
37
Neomycin Approved, Vet_approved Phase 4,Phase 1,Phase 2 1404-04-2 8378
38
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
39
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
40
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 5280965 14956
41
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 36791-04-5 37542
42
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
43
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 174722-31-7 10201696
44
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3056-17-5 18283
45
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 1 6493-05-6 4740
46
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
47
Angiotensin II Approved, Investigational Phase 4,Phase 1,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
48
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136470-78-5 441300 65140
49
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-24-8 5755
50
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7553-56-2 807

Interventional clinical trials:

(show top 50) (show all 10000)

# Name Status NCT ID Phase Drugs
1 Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Medical Staff. Unknown status NCT01063608 Phase 4
2 Treatment of Liver Cirrhosis Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir Unknown status NCT02241590 Phase 4 Entecavir + Placebo;Entecavir + Fuzheng Huayu Tablet
3 Efficacy of Antiviral Therapy After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma Unknown status NCT00768157 Phase 4 antiviral treatment (lamivudine or entecavir)
4 Hepatitis C in Renal Transplant Recipients Unknown status NCT02108301 Phase 4 tacrolimus-cyclosporine A
5 Synergistic Treatment for Hepatocellular Carcinoma (HCC) Using Transcatheter Arterial Chemoembolization (TACE) With Anti-hepatitis B Virus (Anti-HBV) Therapy Unknown status NCT01102335 Phase 4 Telbivudine
6 The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A Unknown status NCT01127282 Phase 4 Vitamin (vitamin A 15 mg,C 500 mg, E 400IU);Placebo (digestive tablet)
7 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
8 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
9 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
10 Peginterferon Alfa-2a, Ribavirin, Amantadine/Placebo in Hepatitis C Virus (HCV)-Genotype-1-Infection (PRAMA) Unknown status NCT00127777 Phase 4 Amantadine sulphate (in addition to standard treatment)
11 Entecavir for Chronic Hepatitis B Patients With Persistently Normal ALT Unknown status NCT01833611 Phase 4 Entecavir;placebo
12 Entecavir Plus Tenofovir Combination in Subjects With Multi-drug Resistant Chronic Hepatitis B Virus Infection Unknown status NCT01594905 Phase 4 Entecavir + Tenofovir (MDR group)
13 Hepatitis B Virus (HBV) Antibody (Anti-HBs) Booster Program for the Production of Hepatitis B Immune Globulin (HBIG) Unknown status NCT01311674 Phase 4
14 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
15 Ciprofloxacin for Prevention of BK Infection Unknown status NCT01789203 Phase 4 Ciprofloxacin;placebo
16 Entecavir for Patients With Decompensated Hepatitis B Virus (HBV)-Related Cirrhosis Unknown status NCT00663182 Phase 4 Entecavir
17 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
18 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
19 Traditional Chinese Medicine Combined With Entecavir to Treat Refractory Liver Fibrosis in Liver Cirrhosis Due to HBV Unknown status NCT02241616 Phase 4 Entecavir+Fuzheng Huayu+TCM Granule
20 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
21 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
22 TO Compare the Triple Drug Therapy and Dual Therapy . Unknown status NCT02075242 Phase 4 Mycophenolate Mofetil;Tacrolimus
23 Hansenula-derived Pegylated Interferon in Treatment of Patients With Chronic Hepatitis C Unknown status NCT01649245 Phase 4 Reiferon retard
24 Improved Prevention of Perinatal Hepatitis B Transmission Unknown status NCT01133184 Phase 4
25 Phase IV Study to Evaluate the Efficacy/Safety to Extend Treatment and High Dose of Ribavirin in co-Infected Patients Unknown status NCT00526448 Phase 4 ribavirin;ribavirin;Peginterferon alfa-2a;epoetin beta
26 Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults Unknown status NCT01811823 Phase 4
27 Banlangen Granules Anti-seasonal Influenza Study Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
28 Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1)Pneumonia: Multi-centre, Prospective, Randomized Controlled Study Unknown status NCT00936013 Phase 4 oseltamivir;oseltamivir and chinese medicinal herbs
29 Antiviral Therapy in Hepatitis B Virus (HBV)-Related Advanced Liver Disease Patients Unknown status NCT00823550 Phase 4 Entecavir;Lamivudine
30 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
31 Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy Unknown status NCT02638233 Phase 4 Sofosbuvir 400mg / Ledipasvir 90 mg (FDC)
32 Efficacy and Safety Study of Telbivudine to Prevent Perinatal Transmission Unknown status NCT00939068 Phase 4 Telbivudine
33 Study to Evaluate the Non-inferiority of Cavir in HBeAg(+)Chronic Hepatitis B Patients Treated With Baraclude Unknown status NCT02523547 Phase 4 Cavir;Baraclude
34 7-valent Pneumococcal Conjugated Vaccination Unknown status NCT00885625 Phase 4
35 Cellular Immunity in Adult Hepatitis B-vaccinated Serologic Non-responders Unknown status NCT01451801 Phase 4
36 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
37 Twinrix Alternative Schedule Study Unknown status NCT00216229 Phase 4
38 Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring Unknown status NCT00836212 Phase 4 Reducing dose of Lopinavir;Reducing dose of efavirenz
39 Efficacy Optimizing Research of Chronic Hepatitis B Patients With Inadequate Response to NUC Therapy Unknown status NCT01341743 Phase 4 Entecavir;Entecavir, Adefovir;Entecavir, Adefovir
40 Using Entecavir to Reduce Hepatitis in Highly Viremic HBV Patients During Anti-tuberculous Treatment Unknown status NCT01724723 Phase 4 entecavir (BARACLUDE®)
41 A Trial To Study The Effect Of Lamivudine In Adult Patients Who Suffer From Chronic Hepatitis B Alone Unknown status NCT00354653 Phase 4 LAMIVUDINE
42 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Unknown status NCT01398540 Phase 4
43 Safety and Immunogenicity of Zostavax Vaccine in Patients Undergoing Living Donor Kidney Transplantation Unknown status NCT00940940 Phase 4
44 Pegylated Interferon Alfa-2b Plus Ribavirin in Chronic Hepatitis B and Delta Unknown status NCT00117533 Phase 4 pegylated IFN alfa-2b plus ribavirin
45 The Effects of Oral Hypoglycemic Agents on Chronic Hepatitis C Patients Receiving Peg-Intron Plus Ribavirin Unknown status NCT01025765 Phase 4 Pioglitazone;Acarbose;Metformin
46 Efficacy and Safety of Daclatasvir Plus Asunaprevir in Chronic Hepatitis C Unknown status NCT02639585 Phase 4 Daclinza and Sunvepra
47 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
48 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
49 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
50 Sustained Off-treatment Response After HBeAg Loss in Chronic Hepatitis B Patients Treated With Nucleos(t)Ide Analogues Unknown status NCT01911156 Phase 4 Continue NA treatment;Discontinue NA Treatment

Search NIH Clinical Center for Viral Infectious Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: arbovirus infections

Genetic Tests for Viral Infectious Disease

Anatomical Context for Viral Infectious Disease

MalaCards organs/tissues related to Viral Infectious Disease:

38
Liver, Testes, T Cells, Kidney, B Cells, Bone, Lung

Publications for Viral Infectious Disease

Articles related to Viral Infectious Disease:

# Title Authors Year
1
Evolutionary analysis of the dynamics of viral infectious disease. ( 19564871 )
2009
2
Viral infectious disease and natural products with antiviral activity. ( 22504360 )
2007
3
IL12 in acute viral infectious disease. ( 8839166 )
1995