MCID: VRL012
MIFTS: 49

Viral Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Viral Meningitis

MalaCards integrated aliases for Viral Meningitis:

Name: Viral Meningitis 12 3 14 69
Meningitis, Viral 41
Meningitis Viral 51

Classifications:



Summaries for Viral Meningitis

CDC : 3 Español: Meningitis viral

MalaCards based summary : Viral Meningitis, also known as meningitis, viral, is related to meningitis and encephalitis. An important gene associated with Viral Meningitis is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Salmon Calcitonin and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Viral meningitis, also known as aseptic meningitis, is a type of meningitis due to a viral infection. It... more...

Related Diseases for Viral Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Viral Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.5 ADA CCL2 CRP CXCL8 IFNG IL6
2 encephalitis 30.3 CCL2 CCL5 CXCL10
3 bacterial meningitis 29.4 CRP CXCL8 IL6
4 viral infectious disease 29.0 CCL5 CXCL10 CXCL8 IFNG IL6
5 viral encephalitis 28.0 CCL2 CCL5 CXCL10 CXCL8 IL6
6 mollaret meningitis 10.9
7 whiplash 10.5 CCL5 IL16
8 african tick-bite fever 10.5 CCL5 IFNG
9 lymphocytic choriomeningitis 10.5
10 orofacial granulomatosis 10.4 CCL5 IFNG
11 scorpion envenomation 10.4 CCL5 IL6
12 obesity-hypoventilation syndrome 10.3 CCL5 IL6
13 constrictive pericarditis 10.3 ADA SERPINA1
14 anca-associated vasculitis 10.3 IL6 SERPINA1
15 b-cell growth factor 10.3 IFNG IL6
16 immune suppression 10.3 IFNG IL6
17 pulmonary sarcoidosis 10.3 CCL2 CCL5 IFNG
18 ascaris lumbricoides infection 10.3 IFNG IL6
19 pericardial tuberculosis 10.2 ADA IFNG
20 chronic eosinophilic pneumonia 10.2 CCL5 IL6
21 cold agglutinin disease 10.2 CRP IL6
22 acute cervicitis 10.2 CCL5 CXCL10
23 graves' disease 10.2 CCL5 IFNG IL16
24 diabetic foot ulcers 10.2 CRP IL6
25 cryopyrin-associated periodic syndrome 10.2 CRP IL6
26 neutrophilia, hereditary 10.2 CRP IL6
27 acute cholangitis 10.2 CRP IL6
28 transient arthritis 10.2 IL6 SERPINA1
29 fungal meningitis 10.2 CXCL10 IFNG
30 microscopic colitis 10.2 IFNG IL6
31 cardiogenic shock 10.2 CRP IL6
32 miliary tuberculosis 10.2 ADA CRP
33 uremic pruritus 10.2 CRP IL6
34 spinal disease 10.2 CRP IL6
35 castleman disease 10.2 CRP IL6
36 tropical spastic paraparesis 10.2 CCL5 IFNG IL6
37 human immunodeficiency virus infectious disease 10.2 CCL5 IFNG IL6
38 vasculitis 10.2 CCL2 CRP SERPINA1
39 filariasis 10.2 CCL5 IFNG IL6
40 angina pectoris 10.1 CRP IL6
41 stachybotrys chartarum 10.1 CCL2 CCL5 IL6
42 radiculopathy 10.1 CCL2 CCL5 IL6
43 pleural empyema 10.1 ADA CRP
44 proliferative glomerulonephritis 10.1 CCL2 IFNG IL6
45 extrapulmonary tuberculosis 10.1 ADA CCL2 IFNG
46 spotted fever 10.1 CCL5 CXCL10 IFNG
47 vulvovaginitis 10.1 CCL5 CXCL8
48 viral pneumonia 10.1 CRP IL6
49 japanese spotted fever 10.1 CRP CXCL10
50 folliculitis 10.1 CCL5 IFNG

Comorbidity relations with Viral Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Viral Meningitis:



Diseases related to Viral Meningitis

Symptoms & Phenotypes for Viral Meningitis

MGI Mouse Phenotypes related to Viral Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 IL6 TIMP2 ADA CCL5 CD14 CXCL10
2 immune system MP:0005387 9.32 TIMP2 ADA CCL2 CCL5 CD14 CRP

Drugs & Therapeutics for Viral Meningitis

Drugs for Viral Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
2 Bone Density Conservation Agents
3 calcitonin
4 Calcitonin Gene-Related Peptide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Outcomes of EV71 CNS Infection Unknown status NCT00172393
2 Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department Recruiting NCT02898948
3 Central Nervous System Infections in Denmark Recruiting NCT03418441
4 Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children Not yet recruiting NCT03387969
5 A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Viral Meningitis

Cochrane evidence based reviews: meningitis, viral

Genetic Tests for Viral Meningitis

Anatomical Context for Viral Meningitis

MalaCards organs/tissues related to Viral Meningitis:

38
Brain, Spinal Cord, Bone, Neutrophil, T Cells, Testes, Liver

Publications for Viral Meningitis

Articles related to Viral Meningitis:

(show top 50) (show all 160)
# Title Authors Year
1
With a little help from a computer: discriminating between bacterial and viral meningitis based on dominance-based rough set approach analysis. ( 28796045 )
2017
2
Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. ( 28063937 )
2017
3
Diagnostic value of lactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers in bacterial and viral meningitis: A cross-sectional study. ( 28858084 )
2017
4
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children. ( 28866321 )
2017
5
Viral meningitis: current issues in diagnosis and treatment. ( 28118219 )
2017
6
Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil. ( 28320174 )
2017
7
Cerebrospinal fluid ferritin and albumin index: potential candidates for scoring system to differentiate between bacterial and viral meningitis in children. ( 26999689 )
2016
8
Viral meningitis: epidemiology and diagnosis. ( 27527750 )
2016
9
Predominance of enterovirus B and echovirus 30 as cause of viral meningitis in a UK population. ( 27367546 )
2016
10
Meningitis retention syndrome: An unusual complication of viral meningitis. ( 27841204 )
2016
11
Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study. ( 27527749 )
2016
12
The usefulness of serum delta neutrophil index for differentiating bacterial and viral meningitis in the emergency department. ( 27752624 )
2016
13
Viral Meningitis Epidemics and a Single, Recent, Recombinant and Anthroponotic Origin of Swine Vesicular Disease Virus. ( 26508717 )
2015
14
Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children: Evidence From a Meta-Analysis. ( 26378091 )
2015
15
Restricted diffusion of the splenium of the corpus callosum in viral meningitis. ( 24707341 )
2014
16
Cerebral microbleeding in varicella-zoster viral meningitis: an early sign of vasculopathy? ( 24463624 )
2014
17
Confirmed viral meningitis with normal CSF findings. ( 25035443 )
2014
18
Time trends of viral meningitis among young adults in Israel: 1978-2012. ( 24463724 )
2014
19
Molecular characterisation of enteroviruses and clinical findings from a cluster of paediatric viral meningitis cases in Tshwane, South Africa 2010-2011. ( 25176522 )
2014
20
Viral meningitis and encephalitis. ( 23981453 )
2013
21
Comparison of cytokine gene polymorphisms among Greek patients with invasive meningococcal disease or viral meningitis. ( 23378564 )
2013
22
Viral meningitis admitted to an infectious diseases hospital: a retrospective case series. ( 24340533 )
2013
23
Detection of herpes viruses in the cerebrospinal fluid of adults with suspected viral meningitis in Malawi. ( 22798048 )
2013
24
Underreporting of viral encephalitis and viral meningitis, Ireland, 2005-2008. ( 23965781 )
2013
25
Trends in the management of viral meningitis at United States children's hospitals. ( 23530164 )
2013
26
Herpes zoster as a cause of viral meningitis in immunocompetent patients. ( 23307457 )
2013
27
Viral meningitis: which patients can be discharged from the emergency department? ( 22709622 )
2012
28
Impact of polymerase chain reaction results on patient management during a viral meningitis outbreak in Tropical North Queensland. ( 22313560 )
2012
29
Vertebral artery dissection associated with viral meningitis. ( 22909191 )
2012
30
Vogt-Koyanagi-Harada syndrome: a rare but important differential diagnosis of viral meningitis. ( 21905951 )
2012
31
Epidemics of viral meningitis caused by echovirus 6 and 30 in Korea in 2008. ( 22336050 )
2012
32
Acute bacterial and viral meningitis. ( 23221840 )
2012
33
Lumbar puncture is not needed for all patients suspected to have viral meningitis. ( 22340799 )
2012
34
Viral meningitis, active and reserve components, U.S. Armed Forces, 2002-2011. ( 22963254 )
2012
35
Performance of thirteen clinical rules to distinguish bacterial and presumed viral meningitis in Vietnamese children. ( 23209715 )
2012
36
Clinical prediction rule for differentiating tuberculous from viral meningitis. ( 22507645 )
2012
37
Descriptive analysis of viral meningitis in a general hospital: differences in the characteristics between children and adults. ( 21349608 )
2011
38
A dural arteriovenous fistula in cavernous sinus developed from viral meningitis. ( 21748936 )
2011
39
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
40
Patient Education Series. Viral meningitis in adults. ( 21403505 )
2011
41
Cytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitis. ( 20626298 )
2010
42
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. ( 19011611 )
2009
43
CSF lactate level: a useful diagnostic tool to differentiate acute bacterial and viral meningitis. ( 19757692 )
2009
44
Secondary SUNCT syndrome caused by viral meningitis. ( 19444540 )
2009
45
Nondominant hemisphere encephalitis in patient with signs of viral meningitis, New York, USA. ( 19751606 )
2009
46
Clinical features of viral meningitis in adults: significant differences in cerebrospinal fluid findings among herpes simplex virus, varicella zoster virus, and enterovirus infections. ( 18680414 )
2008
47
Acute and recurrent viral meningitis. ( 18579020 )
2008
48
Rarity of bacterial and viral meningitis in areas of Western Greece with fewer than 2,000 inhabitants. ( 18219135 )
2008
49
A new parameter in the differential diagnosis of bacterial and viral meningitis. ( 21063298 )
2008
50
Temporary divergence paralysis in viral meningitis. ( 18562842 )
2008

Variations for Viral Meningitis

Expression for Viral Meningitis

Search GEO for disease gene expression data for Viral Meningitis.

Pathways for Viral Meningitis

Pathways related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2
Show member pathways
13.7 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
3
Show member pathways
13.56 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
4
Show member pathways
13.44 CCL2 CCL5 CXCL8 IFNG IL16 IL6
5
Show member pathways
13.33 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
6
Show member pathways
13.27 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
7
Show member pathways
13.21 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
8
Show member pathways
12.89 CCL2 CCL5 CD14 CXCL8 IL6
9
Show member pathways
12.69 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
10
Show member pathways
12.67 CCL5 CXCL10 CXCL8 IFNG IL6
11
Show member pathways
12.52 CCL2 CD14 IFNG IL6
12 12.5 CCL2 CCL5 CD14 CXCL10 IFNG
13
Show member pathways
12.24 CCL2 CCL5 CRP IFNG IL6
14
Show member pathways
12.23 CCL2 CXCL10 CXCL8 IFNG IL6
15
Show member pathways
12.22 CD14 CXCL8 IFNG IL6
16
Show member pathways
12.11 CXCL8 IFNG IL16 IL6
17
Show member pathways
12.1 CCL2 CCL5 CXCL10 CXCL8
18
Show member pathways
12.07 CD14 CXCL10 CXCL8 IFNG IL6
19
Show member pathways
11.99 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
20
Show member pathways
11.95 CCL2 CCL5 CXCL10 CXCL8
21 11.93 CD14 IFNG IL6
22 11.92 CCL2 CXCL8 IL6
23 11.9 CCL2 CCL5 CXCL10 IL6
24 11.88 CXCL8 IFNG IL6
25 11.85 CCL2 CXCL8 IL6
26 11.85 CCL2 CXCL10 CXCL8 IFNG IL6
27 11.84 CD14 CXCL8 IFNG IL6
28
Show member pathways
11.82 CD14 CXCL8 IL6
29 11.77 CD14 CXCL8 IFNG IL6
30 11.76 CXCL8 IFNG IL6
31 11.72 CD14 CXCL8 IL6
32 11.7 CD14 IFNG IL6
33 11.67 CCL2 CCL5 CXCL8 IFNG IL6
34
Show member pathways
11.63 CXCL8 IFNG IL6
35 11.56 CXCL8 IFNG IL6
36 11.56 CD14 CXCL8 IL6
37 11.42 CCL2 CXCL8 IFNG IL6
38 11.35 CCL2 CCL5 CXCL8 IL6 SERPINA1
39 11.32 CCL2 CXCL8 IL6
40 11.15 CCL2 IFNG TIMP2
41 11.07 CCL5 CXCL8
42 11 CRP CXCL8 IL6
43 10.96 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
44 10.85 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
45 10.71 CCL2 CCL5 CXCL10 CXCL8 IL6

GO Terms for Viral Meningitis

Cellular components related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2 extracellular space GO:0005615 9.4 ADA CCL2 CCL5 CD14 CRP CXCL10

Biological processes related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.86 CCL2 CD14 CXCL10 IFNG
2 cellular response to tumor necrosis factor GO:0071356 9.81 CCL2 CCL5 CXCL8
3 response to virus GO:0009615 9.79 CCL5 CXCL10 IFNG
4 cellular response to interleukin-1 GO:0071347 9.72 CCL2 CCL5 CXCL8
5 chemotaxis GO:0006935 9.72 CCL2 CCL5 CXCL10 CXCL8 IL16
6 cell chemotaxis GO:0060326 9.71 CCL2 CCL5 CXCL10
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 CCL5 IFNG IL6
8 immune response GO:0006955 9.7 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
9 neutrophil chemotaxis GO:0030593 9.69 CCL2 CCL5 CXCL8
10 humoral immune response GO:0006959 9.67 CCL2 IFNG IL6
11 chemokine-mediated signaling pathway GO:0070098 9.67 CCL2 CCL5 CXCL10 CXCL8
12 response to tumor necrosis factor GO:0034612 9.65 CCL5 CD14
13 positive regulation of T cell activation GO:0050870 9.65 ADA CCL2
14 monocyte chemotaxis GO:0002548 9.65 CCL2 CCL5 IL6
15 cellular response to lipopolysaccharide GO:0071222 9.65 CCL2 CD14 CXCL10 CXCL8 IL6
16 positive regulation of JAK-STAT cascade GO:0046427 9.64 CCL5 IL6
17 embryonic digestive tract development GO:0048566 9.64 ADA CXCL8
18 positive regulation of monocyte chemotaxis GO:0090026 9.63 CCL5 CXCL10
19 acute-phase response GO:0006953 9.63 CRP IL6 SERPINA1
20 positive regulation of T cell migration GO:2000406 9.62 CCL5 CXCL10
21 induction of positive chemotaxis GO:0050930 9.62 CXCL8 IL16
22 macrophage chemotaxis GO:0048246 9.61 CCL2 CCL5
23 cellular response to fibroblast growth factor stimulus GO:0044344 9.61 CCL2 CCL5 CXCL8
24 response to molecule of bacterial origin GO:0002237 9.6 CD14 CXCL8
25 PERK-mediated unfolded protein response GO:0036499 9.59 CCL2 CXCL8
26 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.58 CCL5 CXCL8
27 neutrophil activation GO:0042119 9.58 CCL5 CXCL8
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 CCL2 CCL5 CD14
29 negative regulation of lipid storage GO:0010888 9.57 CRP IL6
30 regulation of receptor activity GO:0010469 9.5 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
31 inflammatory response GO:0006954 9.17 CCL2 CCL5 CD14 CRP CXCL10 CXCL8

Molecular functions related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8
2 cytokine activity GO:0005125 9.17 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16

Sources for Viral Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....